

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | water-soluble vitamin biosynthetic process (GO:0042364) | 5.17954953 |
| 2 | proteasome assembly (GO:0043248) | 5.05934609 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.02873352 |
| 4 | DNA deamination (GO:0045006) | 4.86703747 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 4.79044298 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.79044298 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.66870186 |
| 8 | cullin deneddylation (GO:0010388) | 4.45638718 |
| 9 | DNA double-strand break processing (GO:0000729) | 4.43750245 |
| 10 | protein-cofactor linkage (GO:0018065) | 4.39135052 |
| 11 | protein neddylation (GO:0045116) | 4.32783687 |
| 12 | protein deneddylation (GO:0000338) | 4.03863210 |
| 13 | respiratory chain complex IV assembly (GO:0008535) | 3.98215691 |
| 14 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.95584691 |
| 15 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.83681629 |
| 16 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.82841890 |
| 17 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.80280804 |
| 18 | DNA damage response, detection of DNA damage (GO:0042769) | 3.77099082 |
| 19 | protein complex biogenesis (GO:0070271) | 3.76929619 |
| 20 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.75027937 |
| 21 | rRNA modification (GO:0000154) | 3.74221347 |
| 22 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.71461076 |
| 23 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.70781783 |
| 24 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.70781783 |
| 25 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.70781783 |
| 26 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.69922208 |
| 27 | maturation of 5.8S rRNA (GO:0000460) | 3.68274701 |
| 28 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.68141425 |
| 29 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.68141425 |
| 30 | prenylation (GO:0097354) | 3.63252624 |
| 31 | protein prenylation (GO:0018342) | 3.63252624 |
| 32 | chaperone-mediated protein transport (GO:0072321) | 3.62633853 |
| 33 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.60221889 |
| 34 | platelet dense granule organization (GO:0060155) | 3.59903578 |
| 35 | cytochrome complex assembly (GO:0017004) | 3.54786668 |
| 36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.54209150 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.48331436 |
| 38 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.48109601 |
| 39 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.48109601 |
| 40 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.47952885 |
| 41 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.47952885 |
| 42 | NADH dehydrogenase complex assembly (GO:0010257) | 3.47952885 |
| 43 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.46116506 |
| 44 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.46116506 |
| 45 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.43294066 |
| 46 | respiratory electron transport chain (GO:0022904) | 3.42537269 |
| 47 | electron transport chain (GO:0022900) | 3.41253410 |
| 48 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.40139228 |
| 49 | negative regulation of ligase activity (GO:0051352) | 3.38080724 |
| 50 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.38080724 |
| 51 | L-fucose metabolic process (GO:0042354) | 3.35887928 |
| 52 | L-fucose catabolic process (GO:0042355) | 3.35887928 |
| 53 | fucose catabolic process (GO:0019317) | 3.35887928 |
| 54 | C4-dicarboxylate transport (GO:0015740) | 3.33846611 |
| 55 | cellular ketone body metabolic process (GO:0046950) | 3.33691083 |
| 56 | rRNA methylation (GO:0031167) | 3.31187738 |
| 57 | hydrogen ion transmembrane transport (GO:1902600) | 3.29022542 |
| 58 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.25413716 |
| 59 | pseudouridine synthesis (GO:0001522) | 3.24927225 |
| 60 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.24610014 |
| 61 | termination of RNA polymerase III transcription (GO:0006386) | 3.24610014 |
| 62 | lactate metabolic process (GO:0006089) | 3.22892244 |
| 63 | peptidyl-histidine modification (GO:0018202) | 3.21079809 |
| 64 | signal peptide processing (GO:0006465) | 3.17768512 |
| 65 | ATP biosynthetic process (GO:0006754) | 3.17116073 |
| 66 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.15418361 |
| 67 | proton transport (GO:0015992) | 3.15021891 |
| 68 | CENP-A containing nucleosome assembly (GO:0034080) | 3.14614244 |
| 69 | rRNA catabolic process (GO:0016075) | 3.13060562 |
| 70 | hydrogen transport (GO:0006818) | 3.09999015 |
| 71 | ketone body metabolic process (GO:1902224) | 3.09132462 |
| 72 | chromatin remodeling at centromere (GO:0031055) | 3.07345342 |
| 73 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.05247944 |
| 74 | amino acid salvage (GO:0043102) | 3.02773259 |
| 75 | L-methionine salvage (GO:0071267) | 3.02773259 |
| 76 | L-methionine biosynthetic process (GO:0071265) | 3.02773259 |
| 77 | DNA strand renaturation (GO:0000733) | 3.02619998 |
| 78 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.02074663 |
| 79 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.01696721 |
| 80 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.01696721 |
| 81 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.98315426 |
| 82 | ribosome assembly (GO:0042255) | 2.97396529 |
| 83 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.94724973 |
| 84 | intracellular protein transmembrane import (GO:0044743) | 2.94176868 |
| 85 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.92250508 |
| 86 | positive regulation of ligase activity (GO:0051351) | 2.91653887 |
| 87 | indolalkylamine metabolic process (GO:0006586) | 2.90303484 |
| 88 | nucleotide transmembrane transport (GO:1901679) | 2.89502323 |
| 89 | vitamin biosynthetic process (GO:0009110) | 2.87983714 |
| 90 | protein targeting to mitochondrion (GO:0006626) | 2.87684597 |
| 91 | tryptophan metabolic process (GO:0006568) | 2.87187876 |
| 92 | inner mitochondrial membrane organization (GO:0007007) | 2.86705513 |
| 93 | regulation of cellular amine metabolic process (GO:0033238) | 2.86389241 |
| 94 | positive regulation of cell cycle arrest (GO:0071158) | 2.82122993 |
| 95 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.81322533 |
| 96 | histone exchange (GO:0043486) | 2.77699059 |
| 97 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.76870859 |
| 98 | aldehyde catabolic process (GO:0046185) | 2.73381899 |
| 99 | dopamine transport (GO:0015872) | 2.72858429 |
| 100 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.72591899 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.70980233 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.34921168 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.83904956 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.59398377 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.44283738 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.93689453 |
| 7 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.75885740 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.73040307 |
| 9 | VDR_22108803_ChIP-Seq_LS180_Human | 2.65597346 |
| 10 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.54071390 |
| 11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.45439116 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.44586413 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.25822373 |
| 14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.24911812 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.23900990 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.18044876 |
| 17 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.03694124 |
| 18 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.97368037 |
| 19 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.94400970 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.93394235 |
| 21 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.92973315 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.84505631 |
| 23 | EWS_26573619_Chip-Seq_HEK293_Human | 1.75419698 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.69532491 |
| 25 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.68998440 |
| 26 | P300_19829295_ChIP-Seq_ESCs_Human | 1.66280919 |
| 27 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.65642134 |
| 28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.59902342 |
| 29 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.58317618 |
| 30 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.53718615 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.52125387 |
| 32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.47731943 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.44466835 |
| 34 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.44156057 |
| 35 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.43479875 |
| 36 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.39307192 |
| 37 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.37954997 |
| 38 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.37417761 |
| 39 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.37180166 |
| 40 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.32727388 |
| 41 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.32090736 |
| 42 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.31330832 |
| 43 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.30073361 |
| 44 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.30073361 |
| 45 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.29801907 |
| 46 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.29724374 |
| 47 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.27418008 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27413304 |
| 49 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.27188405 |
| 50 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.23515034 |
| 51 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.21117840 |
| 52 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.20485942 |
| 53 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.19601323 |
| 54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19582551 |
| 55 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.18745830 |
| 56 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.18745830 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.16371984 |
| 58 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.16170074 |
| 59 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.16062729 |
| 60 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.13946449 |
| 61 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.12096221 |
| 62 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.11420327 |
| 63 | AR_20517297_ChIP-Seq_VCAP_Human | 1.10626126 |
| 64 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10240102 |
| 65 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10057915 |
| 66 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10057915 |
| 67 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.09400269 |
| 68 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.09111186 |
| 69 | NCOR_22424771_ChIP-Seq_293T_Human | 1.08993884 |
| 70 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.08300189 |
| 71 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.06718529 |
| 72 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04847871 |
| 73 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.03968347 |
| 74 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.02786678 |
| 75 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.02383574 |
| 76 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.02376257 |
| 77 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.02303194 |
| 78 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.01265912 |
| 79 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.00935185 |
| 80 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.00600412 |
| 81 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.99259818 |
| 82 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.98870767 |
| 83 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.98642339 |
| 84 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.97805148 |
| 85 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.96920157 |
| 86 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.95722339 |
| 87 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.95343942 |
| 88 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.95239209 |
| 89 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.94631894 |
| 90 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.94107294 |
| 91 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.93554667 |
| 92 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.93461883 |
| 93 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.93043434 |
| 94 | AR_25329375_ChIP-Seq_VCAP_Human | 0.92933665 |
| 95 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.92533769 |
| 96 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.92396315 |
| 97 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.91771845 |
| 98 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.91416829 |
| 99 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.90567787 |
| 100 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.90541397 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 4.47980299 |
| 2 | MP0008875_abnormal_xenobiotic_pharmacok | 2.78875464 |
| 3 | MP0008877_abnormal_DNA_methylation | 2.73659325 |
| 4 | MP0003283_abnormal_digestive_organ | 2.62414581 |
| 5 | MP0003195_calcinosis | 2.54126259 |
| 6 | MP0003011_delayed_dark_adaptation | 2.50392901 |
| 7 | MP0002736_abnormal_nociception_after | 2.48496559 |
| 8 | MP0005646_abnormal_pituitary_gland | 2.40820977 |
| 9 | MP0001986_abnormal_taste_sensitivity | 2.36743308 |
| 10 | MP0005645_abnormal_hypothalamus_physiol | 2.36544394 |
| 11 | MP0002102_abnormal_ear_morphology | 2.35030201 |
| 12 | MP0002837_dystrophic_cardiac_calcinosis | 2.27511351 |
| 13 | MP0009046_muscle_twitch | 2.27385018 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 2.26780254 |
| 15 | MP0001968_abnormal_touch/_nociception | 2.25727032 |
| 16 | MP0002272_abnormal_nervous_system | 2.22787462 |
| 17 | MP0008872_abnormal_physiological_respon | 2.05270450 |
| 18 | MP0005551_abnormal_eye_electrophysiolog | 1.95542944 |
| 19 | MP0009745_abnormal_behavioral_response | 1.84121912 |
| 20 | MP0005084_abnormal_gallbladder_morpholo | 1.83873806 |
| 21 | MP0005075_abnormal_melanosome_morpholog | 1.79520153 |
| 22 | MP0006036_abnormal_mitochondrial_physio | 1.79338793 |
| 23 | MP0003786_premature_aging | 1.75073037 |
| 24 | MP0000372_irregular_coat_pigmentation | 1.70285248 |
| 25 | MP0003880_abnormal_central_pattern | 1.68800829 |
| 26 | MP0003186_abnormal_redox_activity | 1.63785019 |
| 27 | MP0003718_maternal_effect | 1.60993117 |
| 28 | MP0004145_abnormal_muscle_electrophysio | 1.59705193 |
| 29 | MP0001984_abnormal_olfaction | 1.59209750 |
| 30 | MP0004885_abnormal_endolymph | 1.56720536 |
| 31 | MP0005379_endocrine/exocrine_gland_phen | 1.52619453 |
| 32 | MP0005253_abnormal_eye_physiology | 1.50294166 |
| 33 | MP0002138_abnormal_hepatobiliary_system | 1.46248465 |
| 34 | MP0002064_seizures | 1.43916509 |
| 35 | MP0001501_abnormal_sleep_pattern | 1.42665381 |
| 36 | MP0002876_abnormal_thyroid_physiology | 1.41488766 |
| 37 | MP0005167_abnormal_blood-brain_barrier | 1.33877396 |
| 38 | MP0005423_abnormal_somatic_nervous | 1.33434156 |
| 39 | MP0003806_abnormal_nucleotide_metabolis | 1.31328319 |
| 40 | MP0008058_abnormal_DNA_repair | 1.31128437 |
| 41 | MP0001764_abnormal_homeostasis | 1.30333188 |
| 42 | MP0001486_abnormal_startle_reflex | 1.29765238 |
| 43 | MP0004215_abnormal_myocardial_fiber | 1.27010211 |
| 44 | MP0004957_abnormal_blastocyst_morpholog | 1.26158024 |
| 45 | MP0005332_abnormal_amino_acid | 1.24943622 |
| 46 | MP0004142_abnormal_muscle_tone | 1.24447579 |
| 47 | MP0003252_abnormal_bile_duct | 1.21294009 |
| 48 | MP0002735_abnormal_chemical_nociception | 1.20385667 |
| 49 | MP0005085_abnormal_gallbladder_physiolo | 1.20095757 |
| 50 | MP0006276_abnormal_autonomic_nervous | 1.19674115 |
| 51 | MP0005389_reproductive_system_phenotype | 1.19478047 |
| 52 | MP0002163_abnormal_gland_morphology | 1.19381668 |
| 53 | MP0001529_abnormal_vocalization | 1.18593250 |
| 54 | MP0002572_abnormal_emotion/affect_behav | 1.15980591 |
| 55 | MP0010094_abnormal_chromosome_stability | 1.15319397 |
| 56 | MP0003122_maternal_imprinting | 1.14433737 |
| 57 | MP0003787_abnormal_imprinting | 1.12926237 |
| 58 | MP0009697_abnormal_copulation | 1.11148771 |
| 59 | MP0008775_abnormal_heart_ventricle | 1.10590063 |
| 60 | MP0002160_abnormal_reproductive_system | 1.09615851 |
| 61 | MP0000013_abnormal_adipose_tissue | 1.09059090 |
| 62 | MP0006035_abnormal_mitochondrial_morpho | 1.08225469 |
| 63 | MP0001485_abnormal_pinna_reflex | 1.02611803 |
| 64 | MP0002557_abnormal_social/conspecific_i | 1.02171309 |
| 65 | MP0002733_abnormal_thermal_nociception | 1.02153243 |
| 66 | MP0005636_abnormal_mineral_homeostasis | 1.01591884 |
| 67 | MP0001970_abnormal_pain_threshold | 0.98237071 |
| 68 | MP0010386_abnormal_urinary_bladder | 0.98004996 |
| 69 | MP0003635_abnormal_synaptic_transmissio | 0.96530355 |
| 70 | MP0002938_white_spotting | 0.93764229 |
| 71 | MP0003045_fibrosis | 0.92568563 |
| 72 | MP0003121_genomic_imprinting | 0.91638736 |
| 73 | MP0002693_abnormal_pancreas_physiology | 0.90298075 |
| 74 | MP0001905_abnormal_dopamine_level | 0.89997437 |
| 75 | MP0002067_abnormal_sensory_capabilities | 0.89714503 |
| 76 | MP0002229_neurodegeneration | 0.89675739 |
| 77 | MP0002751_abnormal_autonomic_nervous | 0.89260185 |
| 78 | MP0001919_abnormal_reproductive_system | 0.88794608 |
| 79 | MP0005671_abnormal_response_to | 0.85566412 |
| 80 | MP0004133_heterotaxia | 0.83957040 |
| 81 | MP0000383_abnormal_hair_follicle | 0.82353538 |
| 82 | MP0002006_tumorigenesis | 0.81777717 |
| 83 | MP0002734_abnormal_mechanical_nocicepti | 0.80452941 |
| 84 | MP0002909_abnormal_adrenal_gland | 0.79972098 |
| 85 | MP0000230_abnormal_systemic_arterial | 0.79429769 |
| 86 | MP0003693_abnormal_embryo_hatching | 0.79198618 |
| 87 | MP0005171_absent_coat_pigmentation | 0.78576955 |
| 88 | MP0004924_abnormal_behavior | 0.77370118 |
| 89 | MP0005386_behavior/neurological_phenoty | 0.77370118 |
| 90 | MP0002090_abnormal_vision | 0.77366941 |
| 91 | MP0001929_abnormal_gametogenesis | 0.77163545 |
| 92 | MP0001661_extended_life_span | 0.75746392 |
| 93 | MP0002063_abnormal_learning/memory/cond | 0.73370559 |
| 94 | MP0001835_abnormal_antigen_presentation | 0.73046522 |
| 95 | MP0009780_abnormal_chondrocyte_physiolo | 0.72995864 |
| 96 | MP0001963_abnormal_hearing_physiology | 0.71446950 |
| 97 | MP0010329_abnormal_lipoprotein_level | 0.69993594 |
| 98 | MP0005395_other_phenotype | 0.69491963 |
| 99 | MP0005377_hearing/vestibular/ear_phenot | 0.69417097 |
| 100 | MP0003878_abnormal_ear_physiology | 0.69417097 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Methylmalonic acidemia (HP:0002912) | 4.33861370 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.01966297 |
| 3 | Progressive macrocephaly (HP:0004481) | 3.77511239 |
| 4 | Mitochondrial inheritance (HP:0001427) | 3.77459075 |
| 5 | 3-Methylglutaconic aciduria (HP:0003535) | 3.73105952 |
| 6 | Increased CSF lactate (HP:0002490) | 3.72878705 |
| 7 | Methylmalonic aciduria (HP:0012120) | 3.56806425 |
| 8 | Acute encephalopathy (HP:0006846) | 3.56228638 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.34770202 |
| 10 | Hepatic necrosis (HP:0002605) | 3.32728849 |
| 11 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.32715997 |
| 12 | Abnormality of the labia minora (HP:0012880) | 3.25014320 |
| 13 | Cerebral edema (HP:0002181) | 3.07059452 |
| 14 | Abnormality of methionine metabolism (HP:0010901) | 3.00356765 |
| 15 | Increased hepatocellular lipid droplets (HP:0006565) | 2.96483491 |
| 16 | Large for gestational age (HP:0001520) | 2.95925306 |
| 17 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.83289073 |
| 18 | Abnormality of alanine metabolism (HP:0010916) | 2.83289073 |
| 19 | Hyperalaninemia (HP:0003348) | 2.83289073 |
| 20 | Renal cortical cysts (HP:0000803) | 2.82867607 |
| 21 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.81726885 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 2.78032569 |
| 23 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.74355895 |
| 24 | Dicarboxylic aciduria (HP:0003215) | 2.74355895 |
| 25 | Atonic seizures (HP:0010819) | 2.74129185 |
| 26 | Increased serum lactate (HP:0002151) | 2.72777286 |
| 27 | Decreased central vision (HP:0007663) | 2.60724091 |
| 28 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.58640850 |
| 29 | Pancreatic cysts (HP:0001737) | 2.57084115 |
| 30 | Congenital stationary night blindness (HP:0007642) | 2.56709886 |
| 31 | Dysdiadochokinesis (HP:0002075) | 2.56531609 |
| 32 | Abnormality of vitamin B metabolism (HP:0004340) | 2.55825625 |
| 33 | Increased serum pyruvate (HP:0003542) | 2.55589122 |
| 34 | Abolished electroretinogram (ERG) (HP:0000550) | 2.54941824 |
| 35 | Ketoacidosis (HP:0001993) | 2.54321993 |
| 36 | Hypoglycemic coma (HP:0001325) | 2.51616238 |
| 37 | Optic disc pallor (HP:0000543) | 2.46024376 |
| 38 | Homocystinuria (HP:0002156) | 2.45655934 |
| 39 | Abnormality of homocysteine metabolism (HP:0010919) | 2.45655934 |
| 40 | Congenital, generalized hypertrichosis (HP:0004540) | 2.45010281 |
| 41 | Lactic acidosis (HP:0003128) | 2.44529405 |
| 42 | Inability to walk (HP:0002540) | 2.43735587 |
| 43 | Abnormality of serum amino acid levels (HP:0003112) | 2.41531969 |
| 44 | Microvesicular hepatic steatosis (HP:0001414) | 2.40407068 |
| 45 | Ketosis (HP:0001946) | 2.39990142 |
| 46 | Lethargy (HP:0001254) | 2.38430183 |
| 47 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.36286926 |
| 48 | Colon cancer (HP:0003003) | 2.34342974 |
| 49 | Respiratory failure (HP:0002878) | 2.31415852 |
| 50 | Hypothermia (HP:0002045) | 2.31167463 |
| 51 | Abnormality of glycolysis (HP:0004366) | 2.30174952 |
| 52 | Abnormality of the renal cortex (HP:0011035) | 2.25997768 |
| 53 | Progressive microcephaly (HP:0000253) | 2.25623432 |
| 54 | Cerebral hypomyelination (HP:0006808) | 2.23786198 |
| 55 | Type I transferrin isoform profile (HP:0003642) | 2.23172867 |
| 56 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.19335302 |
| 57 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.19335302 |
| 58 | Renal Fanconi syndrome (HP:0001994) | 2.18216175 |
| 59 | True hermaphroditism (HP:0010459) | 2.17397777 |
| 60 | Pancreatic fibrosis (HP:0100732) | 2.12424285 |
| 61 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.12020645 |
| 62 | Dyschromatopsia (HP:0007641) | 2.11718882 |
| 63 | Hyperglycinuria (HP:0003108) | 2.11263591 |
| 64 | Hypomagnesemia (HP:0002917) | 2.11033401 |
| 65 | Abnormality of the anterior horn cell (HP:0006802) | 2.07199012 |
| 66 | Degeneration of anterior horn cells (HP:0002398) | 2.07199012 |
| 67 | Abnormal biliary tract physiology (HP:0012439) | 2.07075748 |
| 68 | Bile duct proliferation (HP:0001408) | 2.07075748 |
| 69 | Prominent metopic ridge (HP:0005487) | 2.05803474 |
| 70 | Facial diplegia (HP:0001349) | 2.05043039 |
| 71 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.01931992 |
| 72 | Dialeptic seizures (HP:0011146) | 2.00985448 |
| 73 | Neuroendocrine neoplasm (HP:0100634) | 2.00819070 |
| 74 | Nephronophthisis (HP:0000090) | 1.98379367 |
| 75 | Progressive inability to walk (HP:0002505) | 1.95390041 |
| 76 | Conjunctival hamartoma (HP:0100780) | 1.95121461 |
| 77 | CNS demyelination (HP:0007305) | 1.91430205 |
| 78 | Neoplasm of the adrenal gland (HP:0100631) | 1.90363758 |
| 79 | CNS hypomyelination (HP:0003429) | 1.90224824 |
| 80 | Palpitations (HP:0001962) | 1.89934517 |
| 81 | Pendular nystagmus (HP:0012043) | 1.87865455 |
| 82 | Hypoglycemic seizures (HP:0002173) | 1.87383506 |
| 83 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.86867345 |
| 84 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.86535323 |
| 85 | Hypoproteinemia (HP:0003075) | 1.86464141 |
| 86 | Adrenal hypoplasia (HP:0000835) | 1.85983541 |
| 87 | Megaloblastic anemia (HP:0001889) | 1.85009171 |
| 88 | Abnormality of glycine metabolism (HP:0010895) | 1.84760562 |
| 89 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.84760562 |
| 90 | Abnormality of macular pigmentation (HP:0008002) | 1.82985020 |
| 91 | Abnormality of the metopic suture (HP:0005556) | 1.82645555 |
| 92 | Exertional dyspnea (HP:0002875) | 1.81531843 |
| 93 | Absence seizures (HP:0002121) | 1.81485554 |
| 94 | Attenuation of retinal blood vessels (HP:0007843) | 1.80702279 |
| 95 | Gaze-evoked nystagmus (HP:0000640) | 1.79880286 |
| 96 | Fair hair (HP:0002286) | 1.79719890 |
| 97 | Abnormality of midbrain morphology (HP:0002418) | 1.79091206 |
| 98 | Molar tooth sign on MRI (HP:0002419) | 1.79091206 |
| 99 | Congenital sensorineural hearing impairment (HP:0008527) | 1.77790251 |
| 100 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.77042159 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.17460697 |
| 2 | EIF2AK3 | 3.69924272 |
| 3 | MST4 | 3.13156907 |
| 4 | BUB1 | 2.97069190 |
| 5 | EIF2AK1 | 2.72157161 |
| 6 | NEK1 | 2.68912527 |
| 7 | FRK | 2.67178126 |
| 8 | TSSK6 | 2.49502578 |
| 9 | NUAK1 | 2.36704464 |
| 10 | VRK1 | 2.25183195 |
| 11 | TLK1 | 2.20044746 |
| 12 | TAF1 | 2.14203848 |
| 13 | MAP4K2 | 2.12611385 |
| 14 | PLK3 | 2.02897121 |
| 15 | GRK1 | 2.01708384 |
| 16 | PLK2 | 1.99527623 |
| 17 | TXK | 1.97617431 |
| 18 | ZAK | 1.92517172 |
| 19 | SRPK1 | 1.74002378 |
| 20 | BMPR1B | 1.71640594 |
| 21 | ADRBK2 | 1.71406486 |
| 22 | TIE1 | 1.66068547 |
| 23 | STK38L | 1.63958442 |
| 24 | SCYL2 | 1.60033752 |
| 25 | MAP3K12 | 1.56193637 |
| 26 | PDK2 | 1.47862251 |
| 27 | CDC7 | 1.43944025 |
| 28 | PHKG2 | 1.39623743 |
| 29 | PHKG1 | 1.39623743 |
| 30 | PLK4 | 1.32185889 |
| 31 | ACVR1B | 1.21461791 |
| 32 | TRIM28 | 1.10445774 |
| 33 | EIF2AK2 | 1.08581143 |
| 34 | PASK | 1.08512377 |
| 35 | OXSR1 | 1.06879851 |
| 36 | WNK4 | 1.04616309 |
| 37 | TNIK | 1.04259385 |
| 38 | TAOK3 | 1.03582989 |
| 39 | PBK | 1.03149103 |
| 40 | CSNK1G3 | 1.01390024 |
| 41 | STK39 | 0.98729275 |
| 42 | WNK3 | 0.95749122 |
| 43 | CSNK1G2 | 0.95566962 |
| 44 | PINK1 | 0.95145387 |
| 45 | DAPK1 | 0.92305370 |
| 46 | NEK9 | 0.88783373 |
| 47 | KIT | 0.86843818 |
| 48 | CSNK1G1 | 0.86329746 |
| 49 | MYLK | 0.85956398 |
| 50 | MKNK2 | 0.82727157 |
| 51 | TGFBR1 | 0.79050195 |
| 52 | BMPR2 | 0.78681580 |
| 53 | CSNK1A1L | 0.78331810 |
| 54 | CDK8 | 0.77566406 |
| 55 | ALK | 0.76200440 |
| 56 | GRK5 | 0.74110053 |
| 57 | CCNB1 | 0.73252019 |
| 58 | RIPK4 | 0.72548834 |
| 59 | LIMK1 | 0.70905202 |
| 60 | MAPKAPK5 | 0.69233338 |
| 61 | PIK3CG | 0.68569544 |
| 62 | INSRR | 0.65777124 |
| 63 | MAP2K6 | 0.65313634 |
| 64 | CDK19 | 0.64403516 |
| 65 | STK16 | 0.62253191 |
| 66 | IKBKB | 0.59562395 |
| 67 | CSF1R | 0.58389856 |
| 68 | MKNK1 | 0.57776838 |
| 69 | PRKCG | 0.57334398 |
| 70 | FER | 0.55785422 |
| 71 | PLK1 | 0.55158703 |
| 72 | PRKCE | 0.54337915 |
| 73 | MAPK13 | 0.53741456 |
| 74 | TTK | 0.53191424 |
| 75 | MAPKAPK3 | 0.49387008 |
| 76 | CAMK2A | 0.45801038 |
| 77 | DYRK2 | 0.45357814 |
| 78 | PTK2B | 0.44966082 |
| 79 | BCKDK | 0.42972731 |
| 80 | PAK3 | 0.41825040 |
| 81 | CLK1 | 0.41587716 |
| 82 | CAMK2D | 0.40111463 |
| 83 | EPHA4 | 0.39995456 |
| 84 | NTRK3 | 0.39465092 |
| 85 | ERBB3 | 0.39033747 |
| 86 | PRKCI | 0.35559255 |
| 87 | TEC | 0.35425442 |
| 88 | ADRBK1 | 0.35397993 |
| 89 | FGFR2 | 0.34751371 |
| 90 | AURKB | 0.34607453 |
| 91 | PRKCA | 0.34448732 |
| 92 | STK4 | 0.32970566 |
| 93 | NME1 | 0.32316896 |
| 94 | IGF1R | 0.32139473 |
| 95 | BCR | 0.31934898 |
| 96 | MINK1 | 0.31465010 |
| 97 | PRKACA | 0.30981884 |
| 98 | CSNK2A1 | 0.30462623 |
| 99 | PRKG1 | 0.29950938 |
| 100 | OBSCN | 0.29504877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.82536087 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.79807299 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.43084266 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.67672303 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.45655400 |
| 6 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.42960669 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.21373853 |
| 8 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.02080830 |
| 9 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.95746157 |
| 10 | Basal transcription factors_Homo sapiens_hsa03022 | 1.95427314 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.90832017 |
| 12 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.89715878 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 1.83823305 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 1.78407404 |
| 15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.77513115 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.72371263 |
| 17 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.70396047 |
| 18 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.69721522 |
| 19 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.65959968 |
| 20 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.63719091 |
| 21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.63134916 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.60722379 |
| 23 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.53356263 |
| 24 | Mismatch repair_Homo sapiens_hsa03430 | 1.52432026 |
| 25 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.50863733 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.47471816 |
| 27 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.45333844 |
| 28 | Phototransduction_Homo sapiens_hsa04744 | 1.40887506 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.34366100 |
| 30 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.33707916 |
| 31 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32205057 |
| 32 | Peroxisome_Homo sapiens_hsa04146 | 1.19804307 |
| 33 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.18202850 |
| 34 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.16912848 |
| 35 | DNA replication_Homo sapiens_hsa03030 | 1.14658702 |
| 36 | Nicotine addiction_Homo sapiens_hsa05033 | 1.14064420 |
| 37 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11279051 |
| 38 | RNA transport_Homo sapiens_hsa03013 | 1.08983219 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.07997643 |
| 40 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.03505239 |
| 41 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.03371822 |
| 42 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.01152879 |
| 43 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.00407834 |
| 44 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.96242645 |
| 45 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.95507174 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.94844555 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.93466502 |
| 48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.89968198 |
| 49 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.88707835 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.86338261 |
| 51 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.83761003 |
| 52 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.83712388 |
| 53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.83659707 |
| 54 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.83022711 |
| 55 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.82877466 |
| 56 | Ribosome_Homo sapiens_hsa03010 | 0.81251582 |
| 57 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.80953429 |
| 58 | Spliceosome_Homo sapiens_hsa03040 | 0.80656057 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.78920032 |
| 60 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.78267298 |
| 61 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.77947143 |
| 62 | Taste transduction_Homo sapiens_hsa04742 | 0.75302842 |
| 63 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.74261032 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72607685 |
| 65 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.71663011 |
| 66 | Insulin secretion_Homo sapiens_hsa04911 | 0.70777289 |
| 67 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.68636031 |
| 68 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.68340615 |
| 69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.67663396 |
| 70 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67489366 |
| 71 | Mineral absorption_Homo sapiens_hsa04978 | 0.66320736 |
| 72 | GABAergic synapse_Homo sapiens_hsa04727 | 0.65814609 |
| 73 | Base excision repair_Homo sapiens_hsa03410 | 0.65363351 |
| 74 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.64629356 |
| 75 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.64146860 |
| 76 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61296373 |
| 77 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.58195117 |
| 78 | Morphine addiction_Homo sapiens_hsa05032 | 0.53502242 |
| 79 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.53125518 |
| 80 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.52258111 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48689509 |
| 82 | Retinol metabolism_Homo sapiens_hsa00830 | 0.48557922 |
| 83 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.46600588 |
| 84 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.46327116 |
| 85 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.46160734 |
| 86 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.45232530 |
| 87 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44645698 |
| 88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37901842 |
| 89 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.37520239 |
| 90 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.37052593 |
| 91 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.35650097 |
| 92 | Salivary secretion_Homo sapiens_hsa04970 | 0.35302941 |
| 93 | Olfactory transduction_Homo sapiens_hsa04740 | 0.34617327 |
| 94 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33665264 |
| 95 | ABC transporters_Homo sapiens_hsa02010 | 0.32636284 |
| 96 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.32181523 |
| 97 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.31883767 |
| 98 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.31521233 |
| 99 | Circadian entrainment_Homo sapiens_hsa04713 | 0.31124491 |
| 100 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.30829973 |

