GAPDHP74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)5.17954953
2proteasome assembly (GO:0043248)5.05934609
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.02873352
4DNA deamination (GO:0045006)4.86703747
5ATP synthesis coupled proton transport (GO:0015986)4.79044298
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.79044298
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.66870186
8cullin deneddylation (GO:0010388)4.45638718
9DNA double-strand break processing (GO:0000729)4.43750245
10protein-cofactor linkage (GO:0018065)4.39135052
11protein neddylation (GO:0045116)4.32783687
12protein deneddylation (GO:0000338)4.03863210
13respiratory chain complex IV assembly (GO:0008535)3.98215691
14regulation of cellular amino acid metabolic process (GO:0006521)3.95584691
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83681629
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82841890
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.80280804
18DNA damage response, detection of DNA damage (GO:0042769)3.77099082
19protein complex biogenesis (GO:0070271)3.76929619
20DNA catabolic process, exonucleolytic (GO:0000738)3.75027937
21rRNA modification (GO:0000154)3.74221347
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71461076
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.70781783
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70781783
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.70781783
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69922208
27maturation of 5.8S rRNA (GO:0000460)3.68274701
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68141425
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68141425
30prenylation (GO:0097354)3.63252624
31protein prenylation (GO:0018342)3.63252624
32chaperone-mediated protein transport (GO:0072321)3.62633853
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60221889
34platelet dense granule organization (GO:0060155)3.59903578
35cytochrome complex assembly (GO:0017004)3.54786668
36mitochondrial respiratory chain complex assembly (GO:0033108)3.54209150
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48331436
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.48109601
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.48109601
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47952885
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.47952885
42NADH dehydrogenase complex assembly (GO:0010257)3.47952885
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46116506
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46116506
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.43294066
46respiratory electron transport chain (GO:0022904)3.42537269
47electron transport chain (GO:0022900)3.41253410
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.40139228
49negative regulation of ligase activity (GO:0051352)3.38080724
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38080724
51L-fucose metabolic process (GO:0042354)3.35887928
52L-fucose catabolic process (GO:0042355)3.35887928
53fucose catabolic process (GO:0019317)3.35887928
54C4-dicarboxylate transport (GO:0015740)3.33846611
55cellular ketone body metabolic process (GO:0046950)3.33691083
56rRNA methylation (GO:0031167)3.31187738
57hydrogen ion transmembrane transport (GO:1902600)3.29022542
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.25413716
59pseudouridine synthesis (GO:0001522)3.24927225
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.24610014
61termination of RNA polymerase III transcription (GO:0006386)3.24610014
62lactate metabolic process (GO:0006089)3.22892244
63peptidyl-histidine modification (GO:0018202)3.21079809
64signal peptide processing (GO:0006465)3.17768512
65ATP biosynthetic process (GO:0006754)3.17116073
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15418361
67proton transport (GO:0015992)3.15021891
68CENP-A containing nucleosome assembly (GO:0034080)3.14614244
69rRNA catabolic process (GO:0016075)3.13060562
70hydrogen transport (GO:0006818)3.09999015
71ketone body metabolic process (GO:1902224)3.09132462
72chromatin remodeling at centromere (GO:0031055)3.07345342
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05247944
74amino acid salvage (GO:0043102)3.02773259
75L-methionine salvage (GO:0071267)3.02773259
76L-methionine biosynthetic process (GO:0071265)3.02773259
77DNA strand renaturation (GO:0000733)3.02619998
78purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02074663
79ATP hydrolysis coupled proton transport (GO:0015991)3.01696721
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.01696721
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98315426
82ribosome assembly (GO:0042255)2.97396529
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94724973
84intracellular protein transmembrane import (GO:0044743)2.94176868
85folic acid-containing compound biosynthetic process (GO:0009396)2.92250508
86positive regulation of ligase activity (GO:0051351)2.91653887
87indolalkylamine metabolic process (GO:0006586)2.90303484
88nucleotide transmembrane transport (GO:1901679)2.89502323
89vitamin biosynthetic process (GO:0009110)2.87983714
90protein targeting to mitochondrion (GO:0006626)2.87684597
91tryptophan metabolic process (GO:0006568)2.87187876
92inner mitochondrial membrane organization (GO:0007007)2.86705513
93regulation of cellular amine metabolic process (GO:0033238)2.86389241
94positive regulation of cell cycle arrest (GO:0071158)2.82122993
95DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81322533
96histone exchange (GO:0043486)2.77699059
97pteridine-containing compound biosynthetic process (GO:0042559)2.76870859
98aldehyde catabolic process (GO:0046185)2.73381899
99dopamine transport (GO:0015872)2.72858429
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72591899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70980233
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.34921168
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.83904956
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59398377
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44283738
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93689453
7ZNF274_21170338_ChIP-Seq_K562_Hela2.75885740
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73040307
9VDR_22108803_ChIP-Seq_LS180_Human2.65597346
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.54071390
11ELK1_19687146_ChIP-ChIP_HELA_Human2.45439116
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.44586413
13VDR_23849224_ChIP-Seq_CD4+_Human2.25822373
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24911812
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23900990
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18044876
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03694124
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97368037
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94400970
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.93394235
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92973315
22FOXP3_21729870_ChIP-Seq_TREG_Human1.84505631
23EWS_26573619_Chip-Seq_HEK293_Human1.75419698
24IGF1R_20145208_ChIP-Seq_DFB_Human1.69532491
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68998440
26P300_19829295_ChIP-Seq_ESCs_Human1.66280919
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65642134
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59902342
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58317618
30IRF1_19129219_ChIP-ChIP_H3396_Human1.53718615
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.52125387
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47731943
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44466835
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44156057
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.43479875
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39307192
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37954997
38TP53_22573176_ChIP-Seq_HFKS_Human1.37417761
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37180166
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.32727388
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32090736
42ER_23166858_ChIP-Seq_MCF-7_Human1.31330832
43NANOG_19829295_ChIP-Seq_ESCs_Human1.30073361
44SOX2_19829295_ChIP-Seq_ESCs_Human1.30073361
45MYC_18940864_ChIP-ChIP_HL60_Human1.29801907
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29724374
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27418008
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27413304
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27188405
50DCP1A_22483619_ChIP-Seq_HELA_Human1.23515034
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21117840
52GBX2_23144817_ChIP-Seq_PC3_Human1.20485942
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.19601323
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19582551
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.18745830
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18745830
57FUS_26573619_Chip-Seq_HEK293_Human1.16371984
58BCAT_22108803_ChIP-Seq_LS180_Human1.16170074
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.16062729
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13946449
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.12096221
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11420327
63AR_20517297_ChIP-Seq_VCAP_Human1.10626126
64TAF15_26573619_Chip-Seq_HEK293_Human1.10240102
65CBP_20019798_ChIP-Seq_JUKART_Human1.10057915
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10057915
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09400269
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09111186
69NCOR_22424771_ChIP-Seq_293T_Human1.08993884
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08300189
71GABP_19822575_ChIP-Seq_HepG2_Human1.06718529
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04847871
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03968347
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02786678
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02383574
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.02376257
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.02303194
78ERG_20517297_ChIP-Seq_VCAP_Human1.01265912
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00935185
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00600412
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99259818
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98870767
83TCF4_22108803_ChIP-Seq_LS180_Human0.98642339
84MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97805148
85MYC_18555785_ChIP-Seq_MESCs_Mouse0.96920157
86P53_22387025_ChIP-Seq_ESCs_Mouse0.95722339
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95343942
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95239209
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94631894
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94107294
91SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93554667
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93461883
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93043434
94AR_25329375_ChIP-Seq_VCAP_Human0.92933665
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92533769
96MYC_19829295_ChIP-Seq_ESCs_Human0.92396315
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.91771845
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91416829
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90567787
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90541397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.47980299
2MP0008875_abnormal_xenobiotic_pharmacok2.78875464
3MP0008877_abnormal_DNA_methylation2.73659325
4MP0003283_abnormal_digestive_organ2.62414581
5MP0003195_calcinosis2.54126259
6MP0003011_delayed_dark_adaptation2.50392901
7MP0002736_abnormal_nociception_after2.48496559
8MP0005646_abnormal_pituitary_gland2.40820977
9MP0001986_abnormal_taste_sensitivity2.36743308
10MP0005645_abnormal_hypothalamus_physiol2.36544394
11MP0002102_abnormal_ear_morphology2.35030201
12MP0002837_dystrophic_cardiac_calcinosis2.27511351
13MP0009046_muscle_twitch2.27385018
14MP0006072_abnormal_retinal_apoptosis2.26780254
15MP0001968_abnormal_touch/_nociception2.25727032
16MP0002272_abnormal_nervous_system2.22787462
17MP0008872_abnormal_physiological_respon2.05270450
18MP0005551_abnormal_eye_electrophysiolog1.95542944
19MP0009745_abnormal_behavioral_response1.84121912
20MP0005084_abnormal_gallbladder_morpholo1.83873806
21MP0005075_abnormal_melanosome_morpholog1.79520153
22MP0006036_abnormal_mitochondrial_physio1.79338793
23MP0003786_premature_aging1.75073037
24MP0000372_irregular_coat_pigmentation1.70285248
25MP0003880_abnormal_central_pattern1.68800829
26MP0003186_abnormal_redox_activity1.63785019
27MP0003718_maternal_effect1.60993117
28MP0004145_abnormal_muscle_electrophysio1.59705193
29MP0001984_abnormal_olfaction1.59209750
30MP0004885_abnormal_endolymph1.56720536
31MP0005379_endocrine/exocrine_gland_phen1.52619453
32MP0005253_abnormal_eye_physiology1.50294166
33MP0002138_abnormal_hepatobiliary_system1.46248465
34MP0002064_seizures1.43916509
35MP0001501_abnormal_sleep_pattern1.42665381
36MP0002876_abnormal_thyroid_physiology1.41488766
37MP0005167_abnormal_blood-brain_barrier1.33877396
38MP0005423_abnormal_somatic_nervous1.33434156
39MP0003806_abnormal_nucleotide_metabolis1.31328319
40MP0008058_abnormal_DNA_repair1.31128437
41MP0001764_abnormal_homeostasis1.30333188
42MP0001486_abnormal_startle_reflex1.29765238
43MP0004215_abnormal_myocardial_fiber1.27010211
44MP0004957_abnormal_blastocyst_morpholog1.26158024
45MP0005332_abnormal_amino_acid1.24943622
46MP0004142_abnormal_muscle_tone1.24447579
47MP0003252_abnormal_bile_duct1.21294009
48MP0002735_abnormal_chemical_nociception1.20385667
49MP0005085_abnormal_gallbladder_physiolo1.20095757
50MP0006276_abnormal_autonomic_nervous1.19674115
51MP0005389_reproductive_system_phenotype1.19478047
52MP0002163_abnormal_gland_morphology1.19381668
53MP0001529_abnormal_vocalization1.18593250
54MP0002572_abnormal_emotion/affect_behav1.15980591
55MP0010094_abnormal_chromosome_stability1.15319397
56MP0003122_maternal_imprinting1.14433737
57MP0003787_abnormal_imprinting1.12926237
58MP0009697_abnormal_copulation1.11148771
59MP0008775_abnormal_heart_ventricle1.10590063
60MP0002160_abnormal_reproductive_system1.09615851
61MP0000013_abnormal_adipose_tissue1.09059090
62MP0006035_abnormal_mitochondrial_morpho1.08225469
63MP0001485_abnormal_pinna_reflex1.02611803
64MP0002557_abnormal_social/conspecific_i1.02171309
65MP0002733_abnormal_thermal_nociception1.02153243
66MP0005636_abnormal_mineral_homeostasis1.01591884
67MP0001970_abnormal_pain_threshold0.98237071
68MP0010386_abnormal_urinary_bladder0.98004996
69MP0003635_abnormal_synaptic_transmissio0.96530355
70MP0002938_white_spotting0.93764229
71MP0003045_fibrosis0.92568563
72MP0003121_genomic_imprinting0.91638736
73MP0002693_abnormal_pancreas_physiology0.90298075
74MP0001905_abnormal_dopamine_level0.89997437
75MP0002067_abnormal_sensory_capabilities0.89714503
76MP0002229_neurodegeneration0.89675739
77MP0002751_abnormal_autonomic_nervous0.89260185
78MP0001919_abnormal_reproductive_system0.88794608
79MP0005671_abnormal_response_to0.85566412
80MP0004133_heterotaxia0.83957040
81MP0000383_abnormal_hair_follicle0.82353538
82MP0002006_tumorigenesis0.81777717
83MP0002734_abnormal_mechanical_nocicepti0.80452941
84MP0002909_abnormal_adrenal_gland0.79972098
85MP0000230_abnormal_systemic_arterial0.79429769
86MP0003693_abnormal_embryo_hatching0.79198618
87MP0005171_absent_coat_pigmentation0.78576955
88MP0004924_abnormal_behavior0.77370118
89MP0005386_behavior/neurological_phenoty0.77370118
90MP0002090_abnormal_vision0.77366941
91MP0001929_abnormal_gametogenesis0.77163545
92MP0001661_extended_life_span0.75746392
93MP0002063_abnormal_learning/memory/cond0.73370559
94MP0001835_abnormal_antigen_presentation0.73046522
95MP0009780_abnormal_chondrocyte_physiolo0.72995864
96MP0001963_abnormal_hearing_physiology0.71446950
97MP0010329_abnormal_lipoprotein_level0.69993594
98MP0005395_other_phenotype0.69491963
99MP0005377_hearing/vestibular/ear_phenot0.69417097
100MP0003878_abnormal_ear_physiology0.69417097

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)4.33861370
2Acute necrotizing encephalopathy (HP:0006965)4.01966297
3Progressive macrocephaly (HP:0004481)3.77511239
4Mitochondrial inheritance (HP:0001427)3.77459075
53-Methylglutaconic aciduria (HP:0003535)3.73105952
6Increased CSF lactate (HP:0002490)3.72878705
7Methylmalonic aciduria (HP:0012120)3.56806425
8Acute encephalopathy (HP:0006846)3.56228638
9Hepatocellular necrosis (HP:0001404)3.34770202
10Hepatic necrosis (HP:0002605)3.32728849
11Abnormal mitochondria in muscle tissue (HP:0008316)3.32715997
12Abnormality of the labia minora (HP:0012880)3.25014320
13Cerebral edema (HP:0002181)3.07059452
14Abnormality of methionine metabolism (HP:0010901)3.00356765
15Increased hepatocellular lipid droplets (HP:0006565)2.96483491
16Large for gestational age (HP:0001520)2.95925306
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83289073
18Abnormality of alanine metabolism (HP:0010916)2.83289073
19Hyperalaninemia (HP:0003348)2.83289073
20Renal cortical cysts (HP:0000803)2.82867607
21Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81726885
22Lipid accumulation in hepatocytes (HP:0006561)2.78032569
23Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74355895
24Dicarboxylic aciduria (HP:0003215)2.74355895
25Atonic seizures (HP:0010819)2.74129185
26Increased serum lactate (HP:0002151)2.72777286
27Decreased central vision (HP:0007663)2.60724091
28Abnormality of the vitamin B12 metabolism (HP:0004341)2.58640850
29Pancreatic cysts (HP:0001737)2.57084115
30Congenital stationary night blindness (HP:0007642)2.56709886
31Dysdiadochokinesis (HP:0002075)2.56531609
32Abnormality of vitamin B metabolism (HP:0004340)2.55825625
33Increased serum pyruvate (HP:0003542)2.55589122
34Abolished electroretinogram (ERG) (HP:0000550)2.54941824
35Ketoacidosis (HP:0001993)2.54321993
36Hypoglycemic coma (HP:0001325)2.51616238
37Optic disc pallor (HP:0000543)2.46024376
38Homocystinuria (HP:0002156)2.45655934
39Abnormality of homocysteine metabolism (HP:0010919)2.45655934
40Congenital, generalized hypertrichosis (HP:0004540)2.45010281
41Lactic acidosis (HP:0003128)2.44529405
42Inability to walk (HP:0002540)2.43735587
43Abnormality of serum amino acid levels (HP:0003112)2.41531969
44Microvesicular hepatic steatosis (HP:0001414)2.40407068
45Ketosis (HP:0001946)2.39990142
46Lethargy (HP:0001254)2.38430183
47Hyperinsulinemic hypoglycemia (HP:0000825)2.36286926
48Colon cancer (HP:0003003)2.34342974
49Respiratory failure (HP:0002878)2.31415852
50Hypothermia (HP:0002045)2.31167463
51Abnormality of glycolysis (HP:0004366)2.30174952
52Abnormality of the renal cortex (HP:0011035)2.25997768
53Progressive microcephaly (HP:0000253)2.25623432
54Cerebral hypomyelination (HP:0006808)2.23786198
55Type I transferrin isoform profile (HP:0003642)2.23172867
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19335302
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19335302
58Renal Fanconi syndrome (HP:0001994)2.18216175
59True hermaphroditism (HP:0010459)2.17397777
60Pancreatic fibrosis (HP:0100732)2.12424285
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12020645
62Dyschromatopsia (HP:0007641)2.11718882
63Hyperglycinuria (HP:0003108)2.11263591
64Hypomagnesemia (HP:0002917)2.11033401
65Abnormality of the anterior horn cell (HP:0006802)2.07199012
66Degeneration of anterior horn cells (HP:0002398)2.07199012
67Abnormal biliary tract physiology (HP:0012439)2.07075748
68Bile duct proliferation (HP:0001408)2.07075748
69Prominent metopic ridge (HP:0005487)2.05803474
70Facial diplegia (HP:0001349)2.05043039
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01931992
72Dialeptic seizures (HP:0011146)2.00985448
73Neuroendocrine neoplasm (HP:0100634)2.00819070
74Nephronophthisis (HP:0000090)1.98379367
75Progressive inability to walk (HP:0002505)1.95390041
76Conjunctival hamartoma (HP:0100780)1.95121461
77CNS demyelination (HP:0007305)1.91430205
78Neoplasm of the adrenal gland (HP:0100631)1.90363758
79CNS hypomyelination (HP:0003429)1.90224824
80Palpitations (HP:0001962)1.89934517
81Pendular nystagmus (HP:0012043)1.87865455
82Hypoglycemic seizures (HP:0002173)1.87383506
83Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86867345
84Pancreatic islet-cell hyperplasia (HP:0004510)1.86535323
85Hypoproteinemia (HP:0003075)1.86464141
86Adrenal hypoplasia (HP:0000835)1.85983541
87Megaloblastic anemia (HP:0001889)1.85009171
88Abnormality of glycine metabolism (HP:0010895)1.84760562
89Abnormality of serine family amino acid metabolism (HP:0010894)1.84760562
90Abnormality of macular pigmentation (HP:0008002)1.82985020
91Abnormality of the metopic suture (HP:0005556)1.82645555
92Exertional dyspnea (HP:0002875)1.81531843
93Absence seizures (HP:0002121)1.81485554
94Attenuation of retinal blood vessels (HP:0007843)1.80702279
95Gaze-evoked nystagmus (HP:0000640)1.79880286
96Fair hair (HP:0002286)1.79719890
97Abnormality of midbrain morphology (HP:0002418)1.79091206
98Molar tooth sign on MRI (HP:0002419)1.79091206
99Congenital sensorineural hearing impairment (HP:0008527)1.77790251
100Aplasia/hypoplasia of the uterus (HP:0008684)1.77042159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.17460697
2EIF2AK33.69924272
3MST43.13156907
4BUB12.97069190
5EIF2AK12.72157161
6NEK12.68912527
7FRK2.67178126
8TSSK62.49502578
9NUAK12.36704464
10VRK12.25183195
11TLK12.20044746
12TAF12.14203848
13MAP4K22.12611385
14PLK32.02897121
15GRK12.01708384
16PLK21.99527623
17TXK1.97617431
18ZAK1.92517172
19SRPK11.74002378
20BMPR1B1.71640594
21ADRBK21.71406486
22TIE11.66068547
23STK38L1.63958442
24SCYL21.60033752
25MAP3K121.56193637
26PDK21.47862251
27CDC71.43944025
28PHKG21.39623743
29PHKG11.39623743
30PLK41.32185889
31ACVR1B1.21461791
32TRIM281.10445774
33EIF2AK21.08581143
34PASK1.08512377
35OXSR11.06879851
36WNK41.04616309
37TNIK1.04259385
38TAOK31.03582989
39PBK1.03149103
40CSNK1G31.01390024
41STK390.98729275
42WNK30.95749122
43CSNK1G20.95566962
44PINK10.95145387
45DAPK10.92305370
46NEK90.88783373
47KIT0.86843818
48CSNK1G10.86329746
49MYLK0.85956398
50MKNK20.82727157
51TGFBR10.79050195
52BMPR20.78681580
53CSNK1A1L0.78331810
54CDK80.77566406
55ALK0.76200440
56GRK50.74110053
57CCNB10.73252019
58RIPK40.72548834
59LIMK10.70905202
60MAPKAPK50.69233338
61PIK3CG0.68569544
62INSRR0.65777124
63MAP2K60.65313634
64CDK190.64403516
65STK160.62253191
66IKBKB0.59562395
67CSF1R0.58389856
68MKNK10.57776838
69PRKCG0.57334398
70FER0.55785422
71PLK10.55158703
72PRKCE0.54337915
73MAPK130.53741456
74TTK0.53191424
75MAPKAPK30.49387008
76CAMK2A0.45801038
77DYRK20.45357814
78PTK2B0.44966082
79BCKDK0.42972731
80PAK30.41825040
81CLK10.41587716
82CAMK2D0.40111463
83EPHA40.39995456
84NTRK30.39465092
85ERBB30.39033747
86PRKCI0.35559255
87TEC0.35425442
88ADRBK10.35397993
89FGFR20.34751371
90AURKB0.34607453
91PRKCA0.34448732
92STK40.32970566
93NME10.32316896
94IGF1R0.32139473
95BCR0.31934898
96MINK10.31465010
97PRKACA0.30981884
98CSNK2A10.30462623
99PRKG10.29950938
100OBSCN0.29504877

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82536087
2Protein export_Homo sapiens_hsa030603.79807299
3Oxidative phosphorylation_Homo sapiens_hsa001903.43084266
4Parkinsons disease_Homo sapiens_hsa050122.67672303
5RNA polymerase_Homo sapiens_hsa030202.45655400
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42960669
7One carbon pool by folate_Homo sapiens_hsa006702.21373853
8Vitamin B6 metabolism_Homo sapiens_hsa007502.02080830
9Propanoate metabolism_Homo sapiens_hsa006401.95746157
10Basal transcription factors_Homo sapiens_hsa030221.95427314
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90832017
12Butanoate metabolism_Homo sapiens_hsa006501.89715878
13Alzheimers disease_Homo sapiens_hsa050101.83823305
14Homologous recombination_Homo sapiens_hsa034401.78407404
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77513115
16Huntingtons disease_Homo sapiens_hsa050161.72371263
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70396047
18Collecting duct acid secretion_Homo sapiens_hsa049661.69721522
19Nitrogen metabolism_Homo sapiens_hsa009101.65959968
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63719091
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63134916
22RNA degradation_Homo sapiens_hsa030181.60722379
23Non-homologous end-joining_Homo sapiens_hsa034501.53356263
24Mismatch repair_Homo sapiens_hsa034301.52432026
25Tryptophan metabolism_Homo sapiens_hsa003801.50863733
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47471816
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45333844
28Phototransduction_Homo sapiens_hsa047441.40887506
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34366100
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.33707916
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32205057
32Peroxisome_Homo sapiens_hsa041461.19804307
33Caffeine metabolism_Homo sapiens_hsa002321.18202850
34Fatty acid elongation_Homo sapiens_hsa000621.16912848
35DNA replication_Homo sapiens_hsa030301.14658702
36Nicotine addiction_Homo sapiens_hsa050331.14064420
37Cardiac muscle contraction_Homo sapiens_hsa042601.11279051
38RNA transport_Homo sapiens_hsa030131.08983219
39Purine metabolism_Homo sapiens_hsa002301.07997643
40Linoleic acid metabolism_Homo sapiens_hsa005911.03505239
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03371822
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01152879
43Nucleotide excision repair_Homo sapiens_hsa034201.00407834
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96242645
45Pyrimidine metabolism_Homo sapiens_hsa002400.95507174
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.94844555
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93466502
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89968198
49Fatty acid degradation_Homo sapiens_hsa000710.88707835
50Steroid biosynthesis_Homo sapiens_hsa001000.86338261
51Pyruvate metabolism_Homo sapiens_hsa006200.83761003
52Sulfur metabolism_Homo sapiens_hsa009200.83712388
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.83659707
54Regulation of autophagy_Homo sapiens_hsa041400.83022711
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82877466
56Ribosome_Homo sapiens_hsa030100.81251582
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.80953429
58Spliceosome_Homo sapiens_hsa030400.80656057
59Glutathione metabolism_Homo sapiens_hsa004800.78920032
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78267298
61Selenocompound metabolism_Homo sapiens_hsa004500.77947143
62Taste transduction_Homo sapiens_hsa047420.75302842
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74261032
64Metabolic pathways_Homo sapiens_hsa011000.72607685
65Fatty acid metabolism_Homo sapiens_hsa012120.71663011
66Insulin secretion_Homo sapiens_hsa049110.70777289
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68636031
68Type I diabetes mellitus_Homo sapiens_hsa049400.68340615
69Rheumatoid arthritis_Homo sapiens_hsa053230.67663396
70Carbon metabolism_Homo sapiens_hsa012000.67489366
71Mineral absorption_Homo sapiens_hsa049780.66320736
72GABAergic synapse_Homo sapiens_hsa047270.65814609
73Base excision repair_Homo sapiens_hsa034100.65363351
74Synaptic vesicle cycle_Homo sapiens_hsa047210.64629356
75beta-Alanine metabolism_Homo sapiens_hsa004100.64146860
76Chemical carcinogenesis_Homo sapiens_hsa052040.61296373
77Ether lipid metabolism_Homo sapiens_hsa005650.58195117
78Morphine addiction_Homo sapiens_hsa050320.53502242
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53125518
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52258111
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48689509
82Retinol metabolism_Homo sapiens_hsa008300.48557922
83Fanconi anemia pathway_Homo sapiens_hsa034600.46600588
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46327116
85Arachidonic acid metabolism_Homo sapiens_hsa005900.46160734
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45232530
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44645698
88Circadian rhythm_Homo sapiens_hsa047100.37901842
89Antigen processing and presentation_Homo sapiens_hsa046120.37520239
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37052593
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.35650097
92Salivary secretion_Homo sapiens_hsa049700.35302941
93Olfactory transduction_Homo sapiens_hsa047400.34617327
94Primary immunodeficiency_Homo sapiens_hsa053400.33665264
95ABC transporters_Homo sapiens_hsa020100.32636284
96Glycerolipid metabolism_Homo sapiens_hsa005610.32181523
97Fat digestion and absorption_Homo sapiens_hsa049750.31883767
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31521233
99Circadian entrainment_Homo sapiens_hsa047130.31124491
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30829973

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