ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil migration (GO:0072677)	9.57142566
2	regulation of sister chromatid cohesion (GO:0007063)	9.56107966
3	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.36651249
4	regulation of mononuclear cell migration (GO:0071675)	9.32186196
5	branch elongation of an epithelium (GO:0060602)	8.30538030
6	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	8.09673524
7	fucose catabolic process (GO:0019317)	8.06800031
8	L-fucose metabolic process (GO:0042354)	8.06800031
9	L-fucose catabolic process (GO:0042355)	8.06800031
10	positive regulation of chromosome segregation (GO:0051984)	7.86640106
11	ribosomal small subunit assembly (GO:0000028)	7.60471233
12	vesicle fusion (GO:0006906)	7.59217015
13	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.58086305
14	coenzyme A biosynthetic process (GO:0015937)	7.24366268
15	peptidyl-lysine dimethylation (GO:0018027)	7.22519947
16	macrophage chemotaxis (GO:0048246)	6.85690478
17	autophagic vacuole fusion (GO:0000046)	6.84894646
18	localization within membrane (GO:0051668)	6.47970770
19	organ growth (GO:0035265)	6.45786051
20	axis elongation (GO:0003401)	6.13440450
21	positive regulation of calcium ion import (GO:0090280)	5.93705525
22	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.91970894
23	regulation of T cell receptor signaling pathway (GO:0050856)	5.80160235
24	regulation of beta-amyloid formation (GO:1902003)	5.78995506
25	establishment of mitotic spindle orientation (GO:0000132)	5.71140367
26	negative regulation of GTPase activity (GO:0034260)	5.70236743
27	negative regulation of GTP catabolic process (GO:0033125)	5.70236743
28	protein import into peroxisome matrix (GO:0016558)	5.67483318
29	monocyte chemotaxis (GO:0002548)	5.50787786
30	organelle membrane fusion (GO:0090174)	5.38377944
31	double-strand break repair via nonhomologous end joining (GO:0006303)	5.32851954
32	non-recombinational repair (GO:0000726)	5.32851954
33	establishment of mitotic spindle localization (GO:0040001)	5.07461439
34	oxidative demethylation (GO:0070989)	4.94851422
35	establishment of spindle orientation (GO:0051294)	4.92380890
36	acrosome assembly (GO:0001675)	4.90658218
37	3-UTR-mediated mRNA stabilization (GO:0070935)	4.88617507
38	negative regulation of circadian rhythm (GO:0042754)	4.85434592
39	seminiferous tubule development (GO:0072520)	4.76645316
40	pantothenate metabolic process (GO:0015939)	4.74655369
41	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.71999400
42	fucose metabolic process (GO:0006004)	4.69461514
43	positive chemotaxis (GO:0050918)	4.64252813
44	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.61802277
45	organelle fusion (GO:0048284)	4.59180085
46	histone H3-K9 methylation (GO:0051567)	4.57138092
47	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.56536095
48	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.56536095
49	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.56536095
50	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.40622687
51	coenzyme A metabolic process (GO:0015936)	4.34691455
52	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.33248959
53	fucosylation (GO:0036065)	4.30638163
54	regulation of stem cell maintenance (GO:2000036)	4.26795781
55	regulation of autophagic vacuole assembly (GO:2000785)	4.23413103
56	protein targeting to lysosome (GO:0006622)	4.21969970
57	establishment of protein localization to vacuole (GO:0072666)	4.21969970
58	protein targeting to vacuole (GO:0006623)	4.21969970
59	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.15701451
60	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.02899209
61	membrane budding (GO:0006900)	3.96162163
62	negative regulation of purine nucleotide catabolic process (GO:0033122)	3.90558354
63	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.88780552
64	histone H3-K9 modification (GO:0061647)	3.82035703
65	single-organism membrane fusion (GO:0044801)	3.81387356
66	protein targeting to peroxisome (GO:0006625)	3.80781098
67	establishment of protein localization to peroxisome (GO:0072663)	3.80781098
68	protein localization to peroxisome (GO:0072662)	3.80781098
69	regulation of cellular amide metabolic process (GO:0034248)	3.77612129
70	negative regulation of nucleotide catabolic process (GO:0030812)	3.76953496
71	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.74222087
72	proteasome assembly (GO:0043248)	3.67483782
73	sodium-independent organic anion transport (GO:0043252)	3.64952136
74	negative regulation of macroautophagy (GO:0016242)	3.63306606
75	negative regulation of nucleoside metabolic process (GO:0045978)	3.62654564
76	preassembly of GPI anchor in ER membrane (GO:0016254)	3.61892388
77	establishment of spindle localization (GO:0051293)	3.58772054
78	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.57402031
79	DNA integration (GO:0015074)	3.55312025
80	ER to Golgi vesicle-mediated transport (GO:0006888)	3.54225362
81	peroxisomal transport (GO:0043574)	3.53066963
82	vesicle targeting (GO:0006903)	3.52081165
83	regulation of vacuole organization (GO:0044088)	3.51170029
84	imidazole-containing compound metabolic process (GO:0052803)	3.50285237
85	regulation of calcium ion import (GO:0090279)	3.48918539
86	metallo-sulfur cluster assembly (GO:0031163)	3.41582825
87	iron-sulfur cluster assembly (GO:0016226)	3.41582825
88	telomere maintenance via recombination (GO:0000722)	3.37985956
89	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.34700523
90	DNA demethylation (GO:0080111)	3.34318132
91	Golgi transport vesicle coating (GO:0048200)	3.33684212
92	COPI coating of Golgi vesicle (GO:0048205)	3.33684212
93	protein prenylation (GO:0018342)	12.7594197
94	prenylation (GO:0097354)	12.7594197
95	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.1082449
96	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.1082449
97	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.1082449
98	negative regulation of Ras GTPase activity (GO:0034261)	12.0897397
99	eosinophil chemotaxis (GO:0048245)	10.5845580
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.3671779

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.82378447
2	VDR_22108803_ChIP-Seq_LS180_Human	6.26813827
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.64560764
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.39608713
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.32692808
6	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.68072860
7	ZNF263_19887448_ChIP-Seq_K562_Human	2.61459385
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53426431
9	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.52895689
10	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.51896877
11	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.41728526
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36495894
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14743086
14	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.12284890
15	GATA1_22025678_ChIP-Seq_K562_Human	11.3099411
16	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.88697772
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.85193015
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.72953482
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72953482
20	RXR_22108803_ChIP-Seq_LS180_Human	1.71244327
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69461572
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63719953
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.56675858
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.48416972
25	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.48416972
26	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.48416972
27	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.41163131
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36628755
29	GATA3_26560356_Chip-Seq_TH1_Human	1.35100392
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31043804
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30833407
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.30356706
33	TP53_16413492_ChIP-PET_HCT116_Human	1.27747047
34	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.24802151
35	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.19859557
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.16434499
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16423892
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14010468
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13966149
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.06530397
41	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.06472528
42	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.03544246
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.02490974
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95469151
45	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.95053031
46	CTCF_21964334_Chip-Seq_Bcells_Human	0.93900619
47	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.93760292
48	RUNX_20019798_ChIP-Seq_JUKART_Human	0.93105414
49	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.92761533
50	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.89228270
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88583195
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.86103200
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85819397
54	TP53_22573176_ChIP-Seq_HFKS_Human	0.84097746
55	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.83379623
56	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.81989665
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.81781134
58	ZNF274_21170338_ChIP-Seq_K562_Hela	0.81288492
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.80804557
60	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.78548879
61	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.78017829
62	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.77563578
63	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.75064899
64	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.74106268
65	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.73550604
66	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.71035292
67	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.70947985
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.70872847
69	GATA1_19941826_ChIP-Seq_K562_Human	0.66527388
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.64473083
71	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.64254888
72	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.64038644
73	STAT1_20625510_ChIP-Seq_HELA_Human	0.63335191
74	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.62933224
75	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.62621043
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.61596555
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.61333413
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.61333413
79	HTT_18923047_ChIP-ChIP_STHdh_Human	0.59962458
80	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.59495238
81	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.59433721
82	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.59126715
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.58988464
84	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.58325654
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.58248584
86	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.58009790
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.57838512
88	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.57610095
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.55317910
90	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.54194421
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.53790977
92	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.53746761
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.53455062
94	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.53258250
95	P300_19829295_ChIP-Seq_ESCs_Human	0.53208409
96	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.52925075
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.52460826
98	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.51637195
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.51454301
100	FUS_26573619_Chip-Seq_HEK293_Human	0.51349260

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.95996999
2	MP0006082_CNS_inflammation	5.66724846
3	MP0000467_abnormal_esophagus_morphology	3.25296764
4	MP0001664_abnormal_digestion	3.24712704
5	MP0001663_abnormal_digestive_system	3.18240815
6	MP0001919_abnormal_reproductive_system	2.74601631
7	MP0002751_abnormal_autonomic_nervous	2.53818067
8	MP0000383_abnormal_hair_follicle	2.50051110
9	MP0005381_digestive/alimentary_phenotyp	2.45181040
10	MP0003115_abnormal_respiratory_system	2.42312480
11	MP0002876_abnormal_thyroid_physiology	2.00501718
12	MP0000566_synostosis	12.8762255
13	MP0001915_intracranial_hemorrhage	1.84032995
14	MP0005166_decreased_susceptibility_to	1.78458724
15	MP0010678_abnormal_skin_adnexa	1.68046191
16	MP0005389_reproductive_system_phenotype	1.62273384
17	MP0003937_abnormal_limbs/digits/tail_de	1.51064171
18	MP0003453_abnormal_keratinocyte_physiol	1.46111480
19	MP0000534_abnormal_ureter_morphology	1.44883628
20	MP0001545_abnormal_hematopoietic_system	1.36729248
21	MP0005397_hematopoietic_system_phenotyp	1.36729248
22	MP0000428_abnormal_craniofacial_morphol	1.30247755
23	MP0003763_abnormal_thymus_physiology	1.26290307
24	MP0005076_abnormal_cell_differentiation	1.18362047
25	MP0000490_abnormal_crypts_of	1.12401709
26	MP0005501_abnormal_skin_physiology	1.11262121
27	MP0001764_abnormal_homeostasis	1.03482976
28	MP0001293_anophthalmia	1.03136179
29	MP0001286_abnormal_eye_development	1.02770684
30	MP0000858_altered_metastatic_potential	1.01651277
31	MP0003329_amyloid_beta_deposits	0.93506129
32	MP0002019_abnormal_tumor_incidence	0.91593806
33	MP0010155_abnormal_intestine_physiology	0.84376482
34	MP0002109_abnormal_limb_morphology	0.81014138
35	MP0000470_abnormal_stomach_morphology	0.80099454
36	MP0001963_abnormal_hearing_physiology	0.79727813
37	MP0000026_abnormal_inner_ear	0.74361430
38	MP0000358_abnormal_cell_content/	0.73391543
39	MP0002115_abnormal_skeleton_extremities	0.72901200
40	MP0009763_increased_sensitivity_to	0.72205937
41	MP0002405_respiratory_system_inflammati	0.70969318
42	MP0003942_abnormal_urinary_system	0.68974881
43	MP0005197_abnormal_uvea_morphology	0.67708709
44	MP0000604_amyloidosis	0.65653027
45	MP0000477_abnormal_intestine_morphology	0.63694172
46	MP0002139_abnormal_hepatobiliary_system	0.59200574
47	MP0009672_abnormal_birth_weight	0.56677004
48	MP0005508_abnormal_skeleton_morphology	0.56324114
49	MP0003638_abnormal_response/metabolism_	0.55929305
50	MP0002210_abnormal_sex_determination	0.54073737
51	MP0002184_abnormal_innervation	0.53141054
52	MP0000432_abnormal_head_morphology	0.52066846
53	MP0005253_abnormal_eye_physiology	0.49810562
54	MP0001175_abnormal_lung_morphology	0.47270932
55	MP0002138_abnormal_hepatobiliary_system	0.47032288
56	MP0008058_abnormal_DNA_repair	0.44661029
57	MP0003195_calcinosis	0.44227675
58	MP0005023_abnormal_wound_healing	0.44079222
59	MP0005025_abnormal_response_to	0.43662368
60	MP0005360_urolithiasis	0.43581252
61	MP0000377_abnormal_hair_follicle	0.42932644
62	MP0002113_abnormal_skeleton_development	0.41916300
63	MP0001986_abnormal_taste_sensitivity	0.40164950
64	MP0000681_abnormal_thyroid_gland	0.39854401
65	MP0002168_other_aberrant_phenotype	0.39769188
66	MP0005085_abnormal_gallbladder_physiolo	0.37700044
67	MP0003935_abnormal_craniofacial_develop	0.37585636
68	MP0003448_altered_tumor_morphology	0.36154316
69	MP0000627_abnormal_mammary_gland	0.35962364
70	MP0003868_abnormal_feces_composition	0.35805350
71	MP0005645_abnormal_hypothalamus_physiol	0.35537749
72	MP0005332_abnormal_amino_acid	0.34135037
73	MP0002136_abnormal_kidney_physiology	0.33392165
74	MP0008875_abnormal_xenobiotic_pharmacok	0.33239471
75	MP0003936_abnormal_reproductive_system	0.32467089
76	MP0005391_vision/eye_phenotype	0.32288642
77	MP0002452_abnormal_antigen_presenting	0.32230934
78	MP0002822_catalepsy	0.31865175
79	MP0002277_abnormal_respiratory_mucosa	0.31337492
80	MP0000163_abnormal_cartilage_morphology	0.28995724
81	MP0002752_abnormal_somatic_nervous	0.28868914
82	MP0002736_abnormal_nociception_after	0.28526441
83	MP0000372_irregular_coat_pigmentation	0.28408373
84	MP0001800_abnormal_humoral_immune	0.28387446
85	MP0002735_abnormal_chemical_nociception	0.27711791
86	MP0010771_integument_phenotype	0.27189941
87	MP0005423_abnormal_somatic_nervous	0.26386306
88	MP0005000_abnormal_immune_tolerance	0.26379185
89	MP0006276_abnormal_autonomic_nervous	0.26312393
90	MP0004147_increased_porphyrin_level	0.24832422
91	MP0008004_abnormal_stomach_pH	0.23972199
92	MP0002697_abnormal_eye_size	0.23145079
93	MP0010386_abnormal_urinary_bladder	0.22891126
94	MP0003011_delayed_dark_adaptation	0.22407106
95	MP0002102_abnormal_ear_morphology	0.21916487
96	MP0009931_abnormal_skin_appearance	0.21068916
97	MP0005395_other_phenotype	0.20287373
98	MP0005390_skeleton_phenotype	0.19069536
99	MP0000350_abnormal_cell_proliferation	0.18070809
100	MP0001968_abnormal_touch/_nociception	0.17709820

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.25557257
2	Long foot (HP:0001833)	8.86837095
3	Abnormality of the renal collecting system (HP:0004742)	8.30107303
4	Large for gestational age (HP:0001520)	7.42261005
5	Acute lymphatic leukemia (HP:0006721)	7.01364145
6	Adactyly (HP:0009776)	6.65521350
7	Progressive muscle weakness (HP:0003323)	6.51676241
8	Abnormality of fatty-acid metabolism (HP:0004359)	6.42519680
9	Hypoplastic pelvis (HP:0008839)	6.08747736
10	Autoamputation (HP:0001218)	5.90398260
11	Dry hair (HP:0011359)	5.76466502
12	Ureteral stenosis (HP:0000071)	5.49486067
13	Pulmonary artery stenosis (HP:0004415)	5.44716906
14	Brushfield spots (HP:0001088)	5.31720792
15	Steatorrhea (HP:0002570)	5.26400365
16	Menstrual irregularities (HP:0000858)	5.17867596
17	Ureteral duplication (HP:0000073)	5.12968334
18	Ureteral obstruction (HP:0006000)	5.07793564
19	Hypoplastic nipples (HP:0002557)	4.65285002
20	Abnormal auditory evoked potentials (HP:0006958)	4.57272177
21	Reduced subcutaneous adipose tissue (HP:0003758)	4.39368499
22	Sudden death (HP:0001699)	4.31652643
23	Severe muscular hypotonia (HP:0006829)	4.18331109
24	Fat malabsorption (HP:0002630)	4.08225745
25	Abnormal ventriculo-arterial connection (HP:0011563)	4.07605711
26	Transposition of the great arteries (HP:0001669)	4.07605711
27	Abnormal connection of the cardiac segments (HP:0011545)	4.07605711
28	Anhidrosis (HP:0000970)	3.93398781
29	Decreased lacrimation (HP:0000633)	3.86069109
30	Broad-based gait (HP:0002136)	3.83562905
31	Increased number of teeth (HP:0011069)	3.82972881
32	Palmoplantar hyperkeratosis (HP:0000972)	3.70716914
33	Palmar hyperkeratosis (HP:0010765)	3.48801503
34	Polyneuropathy (HP:0001271)	3.41955646
35	Abnormality of vision evoked potentials (HP:0000649)	3.38289589
36	Wide intermamillary distance (HP:0006610)	3.36686493
37	Broad nasal tip (HP:0000455)	3.20340914
38	Decreased muscle mass (HP:0003199)	3.16030443
39	Generalized amyotrophy (HP:0003700)	3.15084211
40	Polymicrogyria (HP:0002126)	3.10860732
41	Myoglobinuria (HP:0002913)	3.07470627
42	Large hands (HP:0001176)	3.03425822
43	Plantar hyperkeratosis (HP:0007556)	2.97306003
44	Rhabdomyolysis (HP:0003201)	2.90476822
45	Clubbing of toes (HP:0100760)	2.81425294
46	Epiphyseal stippling (HP:0010655)	2.77812736
47	Flat face (HP:0012368)	2.58058984
48	Chorioretinal coloboma (HP:0000567)	2.57130318
49	Overfolded helix (HP:0000396)	2.50936304
50	Basal ganglia calcification (HP:0002135)	2.41454607
51	Widely spaced teeth (HP:0000687)	2.40071392
52	Steppage gait (HP:0003376)	2.37075339
53	Purpura (HP:0000979)	2.36896992
54	Posterior embryotoxon (HP:0000627)	2.32835061
55	Thickened calvaria (HP:0002684)	2.31006207
56	Hypoplastic iliac wings (HP:0002866)	2.30426176
57	Female pseudohermaphroditism (HP:0010458)	2.28022383
58	Abnormality of the line of Schwalbe (HP:0008048)	2.25497093
59	Abnormally folded helix (HP:0008544)	2.22938687
60	Anxiety (HP:0000739)	2.22295133
61	Foot dorsiflexor weakness (HP:0009027)	2.07791790
62	Absent toe (HP:0010760)	2.05614082
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.4968046
64	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.99769061
65	Gangrene (HP:0100758)	1.99763847
66	External ear malformation (HP:0008572)	1.96474145
67	Abnormal epiphyseal ossification (HP:0010656)	1.96032126
68	Thickened nuchal skin fold (HP:0000474)	1.92960348
69	Primary adrenal insufficiency (HP:0008207)	1.92808272
70	Abnormality of the foot musculature (HP:0001436)	1.90724002
71	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.89316813
72	Prenatal maternal abnormality (HP:0002686)	1.88124578
73	Spastic tetraplegia (HP:0002510)	1.85348998
74	Hammertoe (HP:0001765)	1.83521808
75	Congenital onset (HP:0003577)	1.81620792
76	Arthrogryposis multiplex congenita (HP:0002804)	1.80994285
77	Generalized muscle weakness (HP:0003324)	1.78797118
78	Arterial thrombosis (HP:0004420)	1.77559790
79	Lactic acidosis (HP:0003128)	1.73941602
80	Decreased motor nerve conduction velocity (HP:0003431)	1.65193318
81	Stereotypic behavior (HP:0000733)	1.65010229
82	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.63089131
83	Abnormality of the epiphyses of the hand (HP:0005924)	1.58944455
84	Brachycephaly (HP:0000248)	1.55839066
85	Pulmonary embolism (HP:0002204)	1.54834863
86	Depressed nasal ridge (HP:0000457)	1.54756905
87	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.53052654
88	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.51410068
89	Metabolic acidosis (HP:0001942)	1.50306018
90	Scrotal hypoplasia (HP:0000046)	1.49728375
91	Underdeveloped supraorbital ridges (HP:0009891)	1.48744040
92	Short philtrum (HP:0000322)	1.48285645
93	Nail dystrophy (HP:0008404)	1.48198745
94	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.43723117
95	Opacification of the corneal stroma (HP:0007759)	1.41244502
96	Postnatal microcephaly (HP:0005484)	1.36236706
97	Retinopathy (HP:0000488)	1.35933855
98	Abnormality of primary teeth (HP:0006481)	1.29066832
99	Postnatal growth retardation (HP:0008897)	1.27477719
100	Hyperammonemia (HP:0001987)	1.27340613

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.81693474
2	TAOK2	5.63141367
3	TAOK1	5.49499682
4	MAP3K3	4.14630977
5	MAP2K3	3.98987512
6	MAP3K11	3.90707201
7	JAK3	2.48726680
8	MKNK2	11.5275860
9	ABL2	1.90985956
10	DYRK1A	1.73314186
11	MAP3K5	1.32093702
12	SRPK1	1.01626071
13	MAP3K1	0.98813342
14	CHEK2	0.78579780
15	MAP3K8	0.66749322
16	PRKCQ	0.49272599
17	TIE1	0.28533864
18	GRK1	0.21503116
19	CSNK1A1	0.19939415
20	IGF1R	0.16181171
21	ABL1	0.15650998
22	INSRR	0.15487118
23	ADRBK2	0.14687442
24	PIK3CG	0.12980798
25	OBSCN	0.12768024
26	TXK	0.12054793
27	MAP4K2	0.11902026
28	MUSK	0.11790430
29	WNK3	0.11031611
30	PRKCD	0.08580454
31	CSNK2A2	0.07624911
32	GRK7	0.06932968
33	TEC	0.05430167
34	CSNK2A1	0.04230294
35	OXSR1	0.04073587
36	TSSK6	0.03861663
37	CSNK1E	0.03095584
38	PRKCA	0.02253807
39	ZAK	0.01233982
40	AURKA	0.00993050
41	TLK1	0.00853570
42	ITK	0.00375082
43	GRK5	0.00338523
44	PRKCB	0.00199663
45	WNK4	0.00144569
46	PAK3	-0.1112359
47	IKBKB	-0.1108130
48	NUAK1	-0.1067685
49	RPS6KA5	-0.1064910
50	PINK1	-0.1049784
51	NTRK2	-0.1043843
52	MAPKAPK5	-0.1036601
53	CDK2	-0.1022686
54	TBK1	-0.1010592
55	PRKACG	-0.1006858
56	PRKG1	-0.1001044
57	PRKCE	-0.0948653
58	PLK3	-0.0942750
59	IRAK2	-0.0936865
60	BLK	-0.0899534
61	DAPK3	-0.0875356
62	CAMK2G	-0.0867608
63	LYN	-0.0852948
64	MST4	-0.0834407
65	PIM2	-0.0825985
66	IKBKE	-0.0797182
67	ADRBK1	-0.0755307
68	CAMK2A	-0.0745790
69	BCKDK	-0.0735878
70	LMTK2	-0.0725002
71	FES	-0.0611974
72	TGFBR2	-0.0608117
73	EPHA4	-0.0608066
74	GRK6	-0.0596063
75	BUB1	-0.0594943
76	SYK	-0.0571659
77	MST1R	-0.0567596
78	STK39	-0.0565802
79	TESK1	-0.0561146
80	PRKCG	-0.0556209
81	VRK1	-0.0551902
82	TNK2	-0.0536463
83	BMPR1B	-0.0530056
84	BTK	-0.0496677
85	TAOK3	-0.0450708
86	MYLK	-0.0398007
87	PHKG1	-0.0357585
88	PHKG2	-0.0357585
89	SRC	-0.0354225
90	MATK	-0.0293566
91	PLK4	-0.0263592
92	MAP2K6	-0.0243534
93	FRK	-0.0236036
94	CDK8	-0.0217251
95	CCNB1	-0.0203119
96	KDR	-0.0179725
97	PRKACA	-0.0134703
98	MAPK15	-0.0054770
99	ERBB4	-0.0043462
100	KIT	-0.0040424

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.20947160
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.01201785
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.43674678
4	RNA polymerase_Homo sapiens_hsa03020	3.11914127
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.99626923
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.85178300
7	Fatty acid elongation_Homo sapiens_hsa00062	2.82499094
8	Taste transduction_Homo sapiens_hsa04742	2.81713401
9	Butanoate metabolism_Homo sapiens_hsa00650	2.36665002
10	Lysine degradation_Homo sapiens_hsa00310	2.32573941
11	Proteasome_Homo sapiens_hsa03050	2.29057981
12	One carbon pool by folate_Homo sapiens_hsa00670	2.04293180
13	beta-Alanine metabolism_Homo sapiens_hsa00410	2.02619798
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.87576058
15	Propanoate metabolism_Homo sapiens_hsa00640	1.79371398
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.72900620
17	Amoebiasis_Homo sapiens_hsa05146	1.58518357
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.52802665
19	Fatty acid degradation_Homo sapiens_hsa00071	1.23056788
20	Peroxisome_Homo sapiens_hsa04146	1.15622749
21	Viral myocarditis_Homo sapiens_hsa05416	1.11646690
22	Complement and coagulation cascades_Homo sapiens_hsa04610	1.09433096
23	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.09237845
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04292150
25	Fatty acid metabolism_Homo sapiens_hsa01212	0.98313349
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78342852
27	Retinol metabolism_Homo sapiens_hsa00830	0.77331650
28	Asthma_Homo sapiens_hsa05310	0.69329077
29	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67989725
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67067031
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66761684
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64696721
33	Caffeine metabolism_Homo sapiens_hsa00232	0.63911904
34	Allograft rejection_Homo sapiens_hsa05330	0.63367730
35	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62198770
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61903089
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61191011
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60714394
39	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58793062
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58585117
41	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53560248
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52728100
43	Graft-versus-host disease_Homo sapiens_hsa05332	0.52545631
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.52285093
45	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.51438119
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50608080
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49285936
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.48309323
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48039291
50	RNA transport_Homo sapiens_hsa03013	0.47922310
51	AMPK signaling pathway_Homo sapiens_hsa04152	0.47291980
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46971935
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44965037
54	Olfactory transduction_Homo sapiens_hsa04740	0.44809901
55	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.43019830
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.40998477
57	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.39910831
58	Nicotine addiction_Homo sapiens_hsa05033	0.39713636
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.36664213
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36548629
61	Salmonella infection_Homo sapiens_hsa05132	0.35895012
62	Cholinergic synapse_Homo sapiens_hsa04725	0.35073822
63	Purine metabolism_Homo sapiens_hsa00230	0.33233650
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.33053948
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.32387362
66	Malaria_Homo sapiens_hsa05144	0.31497201
67	MicroRNAs in cancer_Homo sapiens_hsa05206	0.31320552
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.30761930
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.30514906
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.29286814
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29037558
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28918666
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28613126
74	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.28049148
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28024007
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27944617
77	TNF signaling pathway_Homo sapiens_hsa04668	0.27908454
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.26686782
79	Choline metabolism in cancer_Homo sapiens_hsa05231	0.26611547
80	Toxoplasmosis_Homo sapiens_hsa05145	0.25067682
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24958336
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.24169983
83	Bile secretion_Homo sapiens_hsa04976	0.23167943
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22793015
85	Phototransduction_Homo sapiens_hsa04744	0.22125288
86	Phagosome_Homo sapiens_hsa04145	0.20784112
87	Metabolic pathways_Homo sapiens_hsa01100	0.20001524
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.19672526
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.19424058
90	Protein digestion and absorption_Homo sapiens_hsa04974	0.18523058
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17657545
92	Carbon metabolism_Homo sapiens_hsa01200	0.16602353
93	GnRH signaling pathway_Homo sapiens_hsa04912	0.15892417
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.14189830
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.12993623
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.12766377
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.12593103
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.12395781
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.12114541
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.10512740

GAPDHP75

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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