ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.75270497
2	proteasome assembly (GO:0043248)	5.60644601
3	synapsis (GO:0007129)	5.45351247
4	DNA double-strand break processing (GO:0000729)	4.95679264
5	signal peptide processing (GO:0006465)	4.51165451
6	respiratory chain complex IV assembly (GO:0008535)	4.50717510
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.34140592
8	platelet dense granule organization (GO:0060155)	4.33373989
9	regulation of cellular amino acid metabolic process (GO:0006521)	4.30086875
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.26242558
11	piRNA metabolic process (GO:0034587)	4.20839423
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.18649045
13	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.16235169
14	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.08214089
15	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.08214089
16	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.08214089
17	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.06813266
18	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.06813266
19	ether lipid metabolic process (GO:0046485)	3.92331928
20	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.88272745
21	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.88272745
22	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.80231552
23	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.80167354
24	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.74849191
25	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.70805203
26	DNA methylation involved in gamete generation (GO:0043046)	3.68488685
27	rRNA methylation (GO:0031167)	3.61371200
28	rRNA modification (GO:0000154)	3.59108258
29	cytidine deamination (GO:0009972)	3.53699412
30	cytidine metabolic process (GO:0046087)	3.53699412
31	cytidine catabolic process (GO:0006216)	3.53699412
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.51800087
33	male meiosis I (GO:0007141)	3.50447833
34	DNA catabolic process, exonucleolytic (GO:0000738)	3.48462642
35	cytochrome complex assembly (GO:0017004)	3.48282785
36	regulation of DNA endoreduplication (GO:0032875)	3.47504171
37	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.46640745
38	oligosaccharide catabolic process (GO:0009313)	3.43457470
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.43237603
40	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.42546614
41	ATP synthesis coupled proton transport (GO:0015986)	3.42546614
42	positive regulation of prostaglandin secretion (GO:0032308)	3.37205516
43	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.36704013
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.33638683
45	negative regulation of ligase activity (GO:0051352)	3.26858365
46	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.26858365
47	positive regulation of cell cycle arrest (GO:0071158)	3.25921831
48	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.23569569
49	protein K6-linked ubiquitination (GO:0085020)	3.22366569
50	DNA damage response, detection of DNA damage (GO:0042769)	3.19060776
51	intracellular protein transmembrane import (GO:0044743)	3.19030735
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15940049
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15940049
54	ketone body metabolic process (GO:1902224)	3.12981351
55	positive regulation of ligase activity (GO:0051351)	3.12545100
56	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.11455824
57	regulation of cellular amine metabolic process (GO:0033238)	3.10810878
58	attachment of spindle microtubules to kinetochore (GO:0008608)	3.09576882
59	protein prenylation (GO:0018342)	3.02509021
60	prenylation (GO:0097354)	3.02509021
61	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.01763066
62	chromosome organization involved in meiosis (GO:0070192)	2.99847927
63	cullin deneddylation (GO:0010388)	2.96613618
64	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.93827710
65	cellular response to glucose starvation (GO:0042149)	2.93509633
66	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.93098546
67	glycerol ether metabolic process (GO:0006662)	2.90783711
68	regulation of prostaglandin secretion (GO:0032306)	2.88319441
69	response to pheromone (GO:0019236)	2.86007166
70	peptidyl-histidine modification (GO:0018202)	2.84434986
71	axoneme assembly (GO:0035082)	2.82834865
72	rRNA catabolic process (GO:0016075)	2.82789700
73	S-adenosylmethionine metabolic process (GO:0046500)	2.77971419
74	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.77208686
75	cellular ketone body metabolic process (GO:0046950)	2.77062066
76	protein deneddylation (GO:0000338)	2.76747602
77	meiosis I (GO:0007127)	2.76583638
78	resolution of meiotic recombination intermediates (GO:0000712)	2.75420645
79	regulation of cell cycle arrest (GO:0071156)	2.70358060
80	branched-chain amino acid catabolic process (GO:0009083)	2.70021024
81	tricarboxylic acid cycle (GO:0006099)	2.69464412
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.69375540
83	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.68294027
84	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.67981671
85	nucleotide transmembrane transport (GO:1901679)	2.67892288
86	negative regulation of execution phase of apoptosis (GO:1900118)	2.67364567
87	ether metabolic process (GO:0018904)	2.67352735
88	lactate metabolic process (GO:0006089)	2.65200469
89	AMP metabolic process (GO:0046033)	2.64388261
90	glucosamine-containing compound catabolic process (GO:1901072)	2.62057846
91	artery smooth muscle contraction (GO:0014824)	2.61536284
92	regulation of ligase activity (GO:0051340)	2.61203286
93	telomere maintenance via telomerase (GO:0007004)	2.60631588
94	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.60537778
95	keratinocyte development (GO:0003334)	2.59760066
96	anterograde synaptic vesicle transport (GO:0048490)	2.59023090
97	positive regulation of fatty acid transport (GO:2000193)	2.58576686
98	negative regulation of cell cycle G1/S phase transition (GO:1902807)	2.54220154
99	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	2.54220154
100	indolalkylamine metabolic process (GO:0006586)	2.52198379

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.37845365
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.50629797
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.48938630
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.57146422
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.49998323
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.19560283
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92468201
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.88464729
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.78241357
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.44914670
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.40431124
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38265799
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.34944534
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26199931
15	VDR_22108803_ChIP-Seq_LS180_Human	2.23233130
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20321103
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14475877
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12783740
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.07018859
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.00635072
21	EWS_26573619_Chip-Seq_HEK293_Human	1.87755471
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.87448664
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81754027
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80093818
25	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.78212655
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.78066712
27	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.77316859
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73298561
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.62196148
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.61086574
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.58335277
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.57086068
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.55512839
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.51919531
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.37856855
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.37022575
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.36897852
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.36298998
39	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35775955
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.34467239
41	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.34309734
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34279261
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30896006
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30309159
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30309159
46	AR_20517297_ChIP-Seq_VCAP_Human	1.30027670
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.28595044
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28493827
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28493827
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28173834
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27783796
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26703839
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26303626
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24910187
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24204638
56	NCOR_22424771_ChIP-Seq_293T_Human	1.21059897
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.20913134
58	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.20016836
59	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.17896355
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.17496936
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14358874
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11097320
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10914641
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.10280602
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09279495
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.06549510
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06490018
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.06295806
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.05720529
70	P300_19829295_ChIP-Seq_ESCs_Human	1.04449235
71	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03965934
72	GATA3_26560356_Chip-Seq_TH2_Human	1.03595541
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03529174
74	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.03517329
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02567453
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02274491
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02084794
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01404574
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01054586
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00375825
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00170090
82	FUS_26573619_Chip-Seq_HEK293_Human	0.99082375
83	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.97005525
84	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.96652142
85	PHF8_20622853_ChIP-Seq_HELA_Human	0.96508533
86	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95101595
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94599755
88	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92905773
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92487064
90	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90509179
91	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90084448
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89734356
93	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.89425149
94	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.88490590
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.87052217
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86974981
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.86798527
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84428622
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84380573
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84008714

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.99114234
2	MP0003646_muscle_fatigue	3.90149159
3	MP0005171_absent_coat_pigmentation	3.32368753
4	MP0000015_abnormal_ear_pigmentation	3.31556448
5	MP0005075_abnormal_melanosome_morpholog	3.14880224
6	MP0002163_abnormal_gland_morphology	3.10606726
7	MP0003806_abnormal_nucleotide_metabolis	2.91272474
8	MP0005408_hypopigmentation	2.78648378
9	MP0005174_abnormal_tail_pigmentation	2.72844574
10	MP0004381_abnormal_hair_follicle	2.71129667
11	MP0008877_abnormal_DNA_methylation	2.60831339
12	MP0005379_endocrine/exocrine_gland_phen	2.58498516
13	MP0000569_abnormal_digit_pigmentation	2.45753021
14	MP0002102_abnormal_ear_morphology	2.43546129
15	MP0003136_yellow_coat_color	2.27609657
16	MP0005645_abnormal_hypothalamus_physiol	2.27016573
17	MP0002938_white_spotting	2.24504973
18	MP0002166_altered_tumor_susceptibility	2.23339576
19	MP0005646_abnormal_pituitary_gland	2.18946522
20	MP0006054_spinal_hemorrhage	2.14382709
21	MP0008875_abnormal_xenobiotic_pharmacok	2.10822330
22	MP0000371_diluted_coat_color	2.10451272
23	MP0003693_abnormal_embryo_hatching	2.07913178
24	MP0002095_abnormal_skin_pigmentation	2.05542560
25	MP0003786_premature_aging	1.80926881
26	MP0003718_maternal_effect	1.80127047
27	MP0006036_abnormal_mitochondrial_physio	1.69505782
28	MP0002006_tumorigenesis	1.66948043
29	MP0005167_abnormal_blood-brain_barrier	1.56548349
30	MP0004145_abnormal_muscle_electrophysio	1.53490750
31	MP0003195_calcinosis	1.53352821
32	MP0008058_abnormal_DNA_repair	1.53208807
33	MP0010094_abnormal_chromosome_stability	1.45657247
34	MP0001661_extended_life_span	1.44708142
35	MP0004019_abnormal_vitamin_homeostasis	1.41835576
36	MP0002160_abnormal_reproductive_system	1.41694496
37	MP0005083_abnormal_biliary_tract	1.40450250
38	MP0004142_abnormal_muscle_tone	1.39194338
39	MP0005084_abnormal_gallbladder_morpholo	1.38903645
40	MP0000427_abnormal_hair_cycle	1.37708107
41	MP0005389_reproductive_system_phenotype	1.35551329
42	MP0002876_abnormal_thyroid_physiology	1.32457739
43	MP0008872_abnormal_physiological_respon	1.32000039
44	MP0001764_abnormal_homeostasis	1.26040548
45	MP0002138_abnormal_hepatobiliary_system	1.25517582
46	MP0005551_abnormal_eye_electrophysiolog	1.25367126
47	MP0008007_abnormal_cellular_replicative	1.23551391
48	MP0002837_dystrophic_cardiac_calcinosis	1.18623620
49	MP0001835_abnormal_antigen_presentation	1.18489158
50	MP0006035_abnormal_mitochondrial_morpho	1.18187458
51	MP0005253_abnormal_eye_physiology	1.17218830
52	MP0001986_abnormal_taste_sensitivity	1.15261891
53	MP0003186_abnormal_redox_activity	1.14206873
54	MP0001485_abnormal_pinna_reflex	1.12609714
55	MP0005365_abnormal_bile_salt	1.10951998
56	MP0004885_abnormal_endolymph	1.10538175
57	MP0000685_abnormal_immune_system	1.05691247
58	MP0005332_abnormal_amino_acid	1.04924892
59	MP0005387_immune_system_phenotype	1.04766238
60	MP0001790_abnormal_immune_system	1.04766238
61	MP0004147_increased_porphyrin_level	0.99708056
62	MP0005671_abnormal_response_to	0.99483727
63	MP0000013_abnormal_adipose_tissue	0.97699557
64	MP0000358_abnormal_cell_content/	0.94653516
65	MP0001984_abnormal_olfaction	0.89809989
66	MP0002075_abnormal_coat/hair_pigmentati	0.89533465
67	MP0004215_abnormal_myocardial_fiber	0.88670301
68	MP0002254_reproductive_system_inflammat	0.87386212
69	MP0000647_abnormal_sebaceous_gland	0.86417781
70	MP0001929_abnormal_gametogenesis	0.85795804
71	MP0001186_pigmentation_phenotype	0.84554135
72	MP0001919_abnormal_reproductive_system	0.84445404
73	MP0006072_abnormal_retinal_apoptosis	0.83910266
74	MP0000383_abnormal_hair_follicle	0.81712254
75	MP0002638_abnormal_pupillary_reflex	0.80810437
76	MP0002210_abnormal_sex_determination	0.79272622
77	MP0004957_abnormal_blastocyst_morpholog	0.77620416
78	MP0008775_abnormal_heart_ventricle	0.77303766
79	MP0001905_abnormal_dopamine_level	0.76707484
80	MP0005330_cardiomyopathy	0.76590802
81	MP0001324_abnormal_eye_pigmentation	0.71448014
82	MP0005395_other_phenotype	0.70707880
83	MP0002693_abnormal_pancreas_physiology	0.70406686
84	MP0005220_abnormal_exocrine_pancreas	0.69059890
85	MP0001666_abnormal_nutrient_absorption	0.68830591
86	MP0001968_abnormal_touch/_nociception	0.68060370
87	MP0002877_abnormal_melanocyte_morpholog	0.66738197
88	MP0001800_abnormal_humoral_immune	0.65405549
89	MP0002148_abnormal_hypersensitivity_rea	0.64331102
90	MP0003698_abnormal_male_reproductive	0.63524689
91	MP0000653_abnormal_sex_gland	0.63240943
92	MP0001145_abnormal_male_reproductive	0.62708148
93	MP0008004_abnormal_stomach_pH	0.60902273
94	MP0003567_abnormal_fetal_cardiomyocyte	0.60121110
95	MP0003866_abnormal_defecation	0.57087822
96	MP0003137_abnormal_impulse_conducting	0.55736978
97	MP0003011_delayed_dark_adaptation	0.55533228
98	MP0009046_muscle_twitch	0.54240290
99	MP0006292_abnormal_olfactory_placode	0.52123780
100	MP0003045_fibrosis	0.51430748

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Albinism (HP:0001022)	3.65956351
2	Increased CSF lactate (HP:0002490)	3.49763624
3	Hepatocellular necrosis (HP:0001404)	3.45459184
4	Delayed CNS myelination (HP:0002188)	3.42281168
5	Congenital stationary night blindness (HP:0007642)	3.38628301
6	Hepatic necrosis (HP:0002605)	3.35876567
7	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.35010409
8	Hypoplasia of the fovea (HP:0007750)	3.35010409
9	Abnormality of glycolysis (HP:0004366)	3.23684701
10	Congenital sensorineural hearing impairment (HP:0008527)	3.15667692
11	Abnormality of methionine metabolism (HP:0010901)	3.13612081
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.12168772
13	Abnormality of alanine metabolism (HP:0010916)	3.12168772
14	Hyperalaninemia (HP:0003348)	3.12168772
15	Increased serum pyruvate (HP:0003542)	3.11197363
16	Abnormality of the renal cortex (HP:0011035)	3.09444426
17	Mitochondrial inheritance (HP:0001427)	2.99417997
18	Acute necrotizing encephalopathy (HP:0006965)	2.95975330
19	Colon cancer (HP:0003003)	2.90450899
20	Increased serum lactate (HP:0002151)	2.90032835
21	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.85462281
22	Acute encephalopathy (HP:0006846)	2.84083501
23	Abnormality of the labia minora (HP:0012880)	2.75689171
24	Abnormality of the fovea (HP:0000493)	2.73819066
25	Constricted visual fields (HP:0001133)	2.64285706
26	Progressive macrocephaly (HP:0004481)	2.59226561
27	Renal cortical cysts (HP:0000803)	2.55140691
28	Adrenal hypoplasia (HP:0000835)	2.53914151
29	Oligodactyly (hands) (HP:0001180)	2.51137345
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.50917116
31	Abnormality of serum amino acid levels (HP:0003112)	2.48155158
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46413370
33	Central scotoma (HP:0000603)	2.41606793
34	Increased IgM level (HP:0003496)	2.40346903
35	Methylmalonic acidemia (HP:0002912)	2.38852879
36	Methylmalonic aciduria (HP:0012120)	2.37728945
37	Congenital, generalized hypertrichosis (HP:0004540)	2.37326289
38	Volvulus (HP:0002580)	2.35611492
39	Aplasia/Hypoplasia of the macula (HP:0008059)	2.32196823
40	Optic disc pallor (HP:0000543)	2.32018755
41	Generalized hypopigmentation of hair (HP:0011358)	2.28670284
42	Hyperglycinemia (HP:0002154)	2.26876420
43	Neoplasm of the adrenal gland (HP:0100631)	2.25693200
44	Cerebral edema (HP:0002181)	2.24960417
45	Stomatitis (HP:0010280)	2.24540307
46	Respiratory failure (HP:0002878)	2.22032843
47	Amniotic constriction ring (HP:0009775)	2.20399723
48	Abnormality of placental membranes (HP:0011409)	2.20399723
49	Abnormal gallbladder physiology (HP:0012438)	2.19795498
50	Cholecystitis (HP:0001082)	2.19795498
51	Hypoplasia of the uterus (HP:0000013)	2.15827924
52	Lipid accumulation in hepatocytes (HP:0006561)	2.14713992
53	Tubulointerstitial nephritis (HP:0001970)	2.14603704
54	Hypoproteinemia (HP:0003075)	2.13716631
55	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.13255310
56	Fair hair (HP:0002286)	2.12560761
57	Parakeratosis (HP:0001036)	2.11769978
58	Papilledema (HP:0001085)	2.08855626
59	CNS demyelination (HP:0007305)	2.06265063
60	Supernumerary spleens (HP:0009799)	2.05746479
61	Pendular nystagmus (HP:0012043)	2.05674363
62	Type I transferrin isoform profile (HP:0003642)	2.05640337
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.05387751
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05115925
65	Increased hepatocellular lipid droplets (HP:0006565)	2.03757778
66	Oligodactyly (HP:0012165)	2.02689702
67	Generalized hypopigmentation (HP:0007513)	2.01602108
68	Lactic acidosis (HP:0003128)	2.01404673
69	Glycosuria (HP:0003076)	2.00885181
70	Abnormality of urine glucose concentration (HP:0011016)	2.00885181
71	Abnormality of macular pigmentation (HP:0008002)	2.00238890
72	Asplenia (HP:0001746)	1.98880278
73	IgG deficiency (HP:0004315)	1.96606620
74	Chronic diarrhea (HP:0002028)	1.96170757
75	Abnormality of the anterior horn cell (HP:0006802)	1.94604640
76	Degeneration of anterior horn cells (HP:0002398)	1.94604640
77	Lethargy (HP:0001254)	1.93513670
78	Abnormal lung lobation (HP:0002101)	1.93501692
79	IgA deficiency (HP:0002720)	1.92643260
80	Large for gestational age (HP:0001520)	1.92195689
81	Abnormal protein glycosylation (HP:0012346)	1.90857310
82	Abnormal glycosylation (HP:0012345)	1.90857310
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90857310
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.90857310
85	Ependymoma (HP:0002888)	1.90716752
86	Chronic hepatic failure (HP:0100626)	1.89750219
87	Congenital ichthyosiform erythroderma (HP:0007431)	1.89626046
88	Neoplasm of the adrenal cortex (HP:0100641)	1.88300216
89	Clubbing of toes (HP:0100760)	1.87123310
90	Attenuation of retinal blood vessels (HP:0007843)	1.84892221
91	Abnormality of vitamin B metabolism (HP:0004340)	1.83841354
92	Cutaneous melanoma (HP:0012056)	1.83169523
93	Scotoma (HP:0000575)	1.82520161
94	3-Methylglutaconic aciduria (HP:0003535)	1.81991931
95	Epiphyseal stippling (HP:0010655)	1.81210593
96	Abnormality of fatty-acid metabolism (HP:0004359)	1.81173200
97	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.79353095
98	Recurrent cutaneous fungal infections (HP:0011370)	1.78575953
99	Chronic mucocutaneous candidiasis (HP:0002728)	1.78575953
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77964365

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.51750506
2	EIF2AK3	3.54301360
3	FRK	3.30906774
4	EIF2AK1	3.12999127
5	BUB1	2.98074499
6	TIE1	2.71120373
7	NUAK1	2.70803796
8	PDK2	2.62036152
9	GRK1	2.55488366
10	TAF1	2.46899413
11	MAP3K12	2.21951782
12	NEK1	2.04471618
13	TSSK6	2.02169443
14	MST4	2.00128857
15	TRIM28	1.96195177
16	BMPR1B	1.93848935
17	MAPKAPK5	1.92162698
18	STK38L	1.86082993
19	ZAK	1.85481870
20	OXSR1	1.82969493
21	CCNB1	1.77163352
22	VRK1	1.74078229
23	MAP4K2	1.73313241
24	PLK3	1.71118414
25	WEE1	1.68896085
26	FER	1.65731920
27	PLK2	1.59880740
28	SMG1	1.57022805
29	DAPK1	1.51807931
30	AKT3	1.45023088
31	ACVR1B	1.38912050
32	TLK1	1.34585623
33	MKNK1	1.34538343
34	ADRBK2	1.32938061
35	PNCK	1.31921622
36	NEK9	1.26661219
37	MYLK	1.25545550
38	EIF2AK2	1.24010169
39	GRK5	1.13326938
40	STK39	1.03901330
41	WNK3	1.00291769
42	PLK4	0.97982666
43	PAK3	0.95184604
44	MAP2K6	0.93012618
45	PRKCI	0.91522427
46	TGFBR1	0.89786640
47	CSNK1G3	0.79513356
48	TEC	0.76286466
49	CSNK1A1L	0.74993197
50	MKNK2	0.73298879
51	CSNK1G1	0.70590202
52	PAK4	0.70402245
53	MELK	0.67651039
54	IKBKB	0.67059716
55	STK3	0.61469559
56	TNIK	0.61009196
57	DAPK3	0.59937613
58	BCKDK	0.59331876
59	NME1	0.59174363
60	MAPKAPK3	0.58985234
61	CSNK1G2	0.57808502
62	FGFR1	0.56923036
63	PAK6	0.56344478
64	SIK3	0.54626745
65	PHKG2	0.54141940
66	PHKG1	0.54141940
67	PLK1	0.52646531
68	MARK3	0.51249833
69	INSRR	0.51162172
70	PBK	0.49992786
71	TAOK3	0.49271101
72	TXK	0.47822562
73	PRKAA2	0.47192428
74	PASK	0.45233561
75	PINK1	0.45091364
76	TYK2	0.45000297
77	TTK	0.44802330
78	PRKCG	0.44039274
79	NLK	0.42347390
80	PRKD3	0.41578831
81	BCR	0.41082128
82	ATR	0.41058845
83	BRAF	0.41000012
84	PAK1	0.37823914
85	SRPK1	0.37571711
86	ADRBK1	0.36751384
87	PRKCE	0.36432456
88	CAMK2D	0.33406337
89	WNK4	0.31090522
90	KIT	0.30932716
91	ATM	0.30848415
92	PTK2B	0.29535513
93	RPS6KA5	0.28888070
94	IGF1R	0.27579090
95	TGFBR2	0.26353965
96	CSNK2A1	0.25521142
97	STK24	0.25519501
98	AURKB	0.24856386
99	CDK9	0.24432499
100	CDK8	0.24406365

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.24889867
2	Protein export_Homo sapiens_hsa03060	2.70029487
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.58668103
4	Homologous recombination_Homo sapiens_hsa03440	2.39068078
5	Propanoate metabolism_Homo sapiens_hsa00640	2.35155926
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.30287922
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.13685792
8	Parkinsons disease_Homo sapiens_hsa05012	2.10451301
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.05966552
10	Sulfur metabolism_Homo sapiens_hsa00920	1.99668808
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.96051871
12	One carbon pool by folate_Homo sapiens_hsa00670	1.84681922
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.81532617
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.79967594
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.72254591
16	RNA degradation_Homo sapiens_hsa03018	1.68214293
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64589754
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.63372307
19	Fatty acid elongation_Homo sapiens_hsa00062	1.61260886
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56252594
21	Asthma_Homo sapiens_hsa05310	1.52969526
22	Butanoate metabolism_Homo sapiens_hsa00650	1.52586750
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.50965550
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49531929
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48824969
26	Mismatch repair_Homo sapiens_hsa03430	1.44247252
27	Peroxisome_Homo sapiens_hsa04146	1.42305875
28	RNA polymerase_Homo sapiens_hsa03020	1.38693815
29	Allograft rejection_Homo sapiens_hsa05330	1.37602585
30	Base excision repair_Homo sapiens_hsa03410	1.35130259
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34321091
32	Caffeine metabolism_Homo sapiens_hsa00232	1.28420520
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.26937989
34	Carbon metabolism_Homo sapiens_hsa01200	1.24867346
35	DNA replication_Homo sapiens_hsa03030	1.24850347
36	Basal transcription factors_Homo sapiens_hsa03022	1.24331870
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23928931
38	Huntingtons disease_Homo sapiens_hsa05016	1.23691489
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23109778
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.22138517
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.19026709
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.17708459
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.16032040
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.12953954
45	Alzheimers disease_Homo sapiens_hsa05010	1.12415116
46	RNA transport_Homo sapiens_hsa03013	1.10967187
47	Type I diabetes mellitus_Homo sapiens_hsa04940	1.09757184
48	Phototransduction_Homo sapiens_hsa04744	1.09496523
49	Fatty acid degradation_Homo sapiens_hsa00071	1.09210947
50	Primary immunodeficiency_Homo sapiens_hsa05340	1.08377856
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07293815
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.03462364
53	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.02614005
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99676253
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.94678046
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.94027989
57	Purine metabolism_Homo sapiens_hsa00230	0.93711833
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.93588409
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90748357
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89515288
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.86813026
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85090831
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.85029182
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80656336
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.79840397
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78358595
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77152936
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.75004032
69	Metabolic pathways_Homo sapiens_hsa01100	0.73919986
70	Glutathione metabolism_Homo sapiens_hsa00480	0.72771599
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70287502
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69480151
73	Retinol metabolism_Homo sapiens_hsa00830	0.64341817
74	Spliceosome_Homo sapiens_hsa03040	0.60225410
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59433176
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.56900070
77	Pentose phosphate pathway_Homo sapiens_hsa00030	0.56480346
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55495257
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55347351
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.55217515
81	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55125336
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54994479
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52478415
84	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52044911
85	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51325322
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50596831
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49903899
88	p53 signaling pathway_Homo sapiens_hsa04115	0.46734199
89	Folate biosynthesis_Homo sapiens_hsa00790	0.46025860
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45756913
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.45522814
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42447219
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42023338
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41765920
95	Ribosome_Homo sapiens_hsa03010	0.38786319
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34342453
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34328464
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32745341
99	Viral myocarditis_Homo sapiens_hsa05416	0.31698498
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30737024

GAPDHP76

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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