GAPDHS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin metabolic process (GO:0006582)9.86706104
2axonemal dynein complex assembly (GO:0070286)9.82331872
3cilium or flagellum-dependent cell motility (GO:0001539)9.60346604
4* spermatid development (GO:0007286)9.54431493
5regulation of cilium movement (GO:0003352)9.50193334
6motile cilium assembly (GO:0044458)9.30676886
7reproduction (GO:0000003)9.30662577
8secondary metabolite biosynthetic process (GO:0044550)8.72701023
9cilium movement (GO:0003341)8.25522002
10sperm capacitation (GO:0048240)7.71739344
11negative regulation of inclusion body assembly (GO:0090084)7.59075410
12single fertilization (GO:0007338)7.53047207
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.46080316
14synaptonemal complex organization (GO:0070193)7.00631195
15male meiosis (GO:0007140)6.87422497
16spermatogenesis (GO:0007283)6.84023635
17organic cation transport (GO:0015695)6.83088993
18male gamete generation (GO:0048232)6.81553113
19piRNA metabolic process (GO:0034587)6.79052699
20synaptonemal complex assembly (GO:0007130)6.77048521
21microtubule depolymerization (GO:0007019)6.73693511
22fertilization (GO:0009566)6.36864926
23regulation of inclusion body assembly (GO:0090083)6.33113962
24gamete generation (GO:0007276)6.26014179
25calcium ion-dependent exocytosis (GO:0017156)5.83569027
26regulation of microtubule-based movement (GO:0060632)5.62070753
27ventricular system development (GO:0021591)5.36317032
28nucleosome disassembly (GO:0006337)5.32427618
29protein-DNA complex disassembly (GO:0032986)5.32427618
30glycerol ether metabolic process (GO:0006662)5.30083558
31chromosome condensation (GO:0030261)5.27921610
32* germ cell development (GO:0007281)5.27127469
33* cellular process involved in reproduction in multicellular organism (GO:0022412)5.26567890
34phosphatidylethanolamine biosynthetic process (GO:0006646)5.11664305
35DNA packaging (GO:0006323)5.03594672
36cell recognition (GO:0008037)4.99140348
37spermatid nucleus differentiation (GO:0007289)4.97477768
38rRNA methylation (GO:0031167)4.95505997
39multicellular organismal reproductive process (GO:0048609)4.95098989
40male meiosis I (GO:0007141)4.93836808
41ether metabolic process (GO:0018904)4.90304579
42nuclear pore complex assembly (GO:0051292)4.74160316
43microtubule severing (GO:0051013)4.68396380
44mitotic G1 DNA damage checkpoint (GO:0031571)4.68362663
45ketone body metabolic process (GO:1902224)4.66475100
46chromosome organization involved in meiosis (GO:0070192)4.55429828
47seminiferous tubule development (GO:0072520)4.55270150
48left/right pattern formation (GO:0060972)4.52812153
49phosphatidylethanolamine metabolic process (GO:0046337)4.52407386
50rRNA modification (GO:0000154)4.29631858
51DNA methylation involved in gamete generation (GO:0043046)4.29193278
52sexual reproduction (GO:0019953)4.27515527
53single strand break repair (GO:0000012)4.20177512
54chaperone-mediated protein complex assembly (GO:0051131)4.15010278
55meiotic nuclear division (GO:0007126)4.13850040
56mitotic G1/S transition checkpoint (GO:0044819)4.09958789
57centriole assembly (GO:0098534)4.07121690
58nuclear pore organization (GO:0006999)4.03465405
59G1 DNA damage checkpoint (GO:0044783)3.98206738
60multicellular organismal development (GO:0007275)3.97434870
61pore complex assembly (GO:0046931)3.92735312
62meiosis I (GO:0007127)3.92417934
63DNA conformation change (GO:0071103)3.88726489
64regulation of phosphoprotein phosphatase activity (GO:0043666)3.79822202
65regulation of centriole replication (GO:0046599)3.76872481
66protein polyglutamylation (GO:0018095)3.68838180
67response to pheromone (GO:0019236)3.65081767
68protein refolding (GO:0042026)3.64599795
69genitalia morphogenesis (GO:0035112)3.63280900
70histone exchange (GO:0043486)3.51171070
71centriole replication (GO:0007099)3.47686226
72peptidyl-arginine omega-N-methylation (GO:0035247)3.44445612
73microtubule polymerization or depolymerization (GO:0031109)3.43316530
74coenzyme catabolic process (GO:0009109)3.32437255
75pigment biosynthetic process (GO:0046148)3.30448600
76phenol-containing compound biosynthetic process (GO:0046189)3.29894154
77regulation of spindle checkpoint (GO:0090231)3.29793306
78centrosome duplication (GO:0051298)3.26025350
79meiotic cell cycle (GO:0051321)3.24798855
80protein localization to cilium (GO:0061512)3.23597648
81protein complex localization (GO:0031503)3.22692034
82nucleus organization (GO:0006997)3.22678401
83monoubiquitinated protein deubiquitination (GO:0035520)3.21849102
84protein K11-linked deubiquitination (GO:0035871)3.21326040
85sequestering of actin monomers (GO:0042989)3.16743749
86mitotic sister chromatid segregation (GO:0000070)3.16627915
87melanocyte differentiation (GO:0030318)3.15775604
88mitotic nuclear envelope disassembly (GO:0007077)3.15403820
89regulation of Rab GTPase activity (GO:0032313)3.13914099
90positive regulation of Rab GTPase activity (GO:0032851)3.13914099
91negative regulation of gene expression, epigenetic (GO:0045814)3.12791408
92RNA localization (GO:0006403)3.12478873
93polyol catabolic process (GO:0046174)3.11348387
94cellular ketone body metabolic process (GO:0046950)3.08799729
95mitotic sister chromatid cohesion (GO:0007064)3.08631927
96amino-acid betaine transport (GO:0015838)3.06232139
97carnitine transport (GO:0015879)3.06232139
98nucleoside diphosphate phosphorylation (GO:0006165)3.04951504
99positive regulation of catecholamine secretion (GO:0033605)3.04902745
100polyamine biosynthetic process (GO:0006596)3.01887194
101membrane disassembly (GO:0030397)2.99022309
102nuclear envelope disassembly (GO:0051081)2.99022309
103developmental pigmentation (GO:0048066)2.98997369
104DNA strand elongation involved in DNA replication (GO:0006271)2.96581841
105sister chromatid segregation (GO:0000819)2.93359144
106RNA destabilization (GO:0050779)2.90177227
107alditol metabolic process (GO:0019400)2.90083896
108ribosome assembly (GO:0042255)2.89670590
109cilium organization (GO:0044782)2.87470144
110negative regulation of histone methylation (GO:0031061)2.87243058
111carnitine transmembrane transport (GO:1902603)2.86132721
112pigment cell differentiation (GO:0050931)2.85694034
113DNA synthesis involved in DNA repair (GO:0000731)2.85541532
114histone arginine methylation (GO:0034969)2.84919511
115DNA strand elongation (GO:0022616)2.84368728
116snRNA metabolic process (GO:0016073)2.84096938
117microtubule-based movement (GO:0007018)2.84082961
118telomere maintenance via semi-conservative replication (GO:0032201)2.81839264
119tRNA methylation (GO:0030488)2.81513662
120melanosome organization (GO:0032438)2.79680374
121regulation of cilium assembly (GO:1902017)2.78366898
122histone H3-K36 demethylation (GO:0070544)2.78099623
123lactate metabolic process (GO:0006089)2.77665136
124cilium assembly (GO:0042384)2.77188588
125mitochondrial fission (GO:0000266)2.75666473
126snRNA processing (GO:0016180)2.75397912
127histone H3-K9 demethylation (GO:0033169)2.74629265
128interferon-gamma secretion (GO:0072643)2.74603811
129intraciliary transport (GO:0042073)2.74550374
130meiotic cell cycle process (GO:1903046)2.73464006
131mitochondrion degradation (GO:0000422)2.73390140
132peptidyl-arginine N-methylation (GO:0035246)2.73080387
133peptidyl-arginine methylation (GO:0018216)2.73080387
134pigment granule organization (GO:0048753)2.71899686
135DNA replication initiation (GO:0006270)2.70866596
136GTP biosynthetic process (GO:0006183)2.69848701
137positive regulation of macrophage activation (GO:0043032)2.68929540
138RNA methylation (GO:0001510)2.68796191
139regulation of DNA damage checkpoint (GO:2000001)2.66903203
140cellular component assembly involved in morphogenesis (GO:0010927)2.65485706
141chromatin silencing (GO:0006342)2.64981161
142negative regulation of organelle assembly (GO:1902116)2.64359960
143cilium morphogenesis (GO:0060271)2.63595017
144axoneme assembly (GO:0035082)2.61561943
145* glycolytic process (GO:0006096)2.61548340
146peptidyl-glutamic acid modification (GO:0018200)2.60089681
147synapsis (GO:0007129)2.58394801
148negative regulation of skeletal muscle tissue development (GO:0048642)2.50153607
149regulation of protein kinase C signaling (GO:0090036)2.42604160
150* sperm motility (GO:0030317)14.2334130
151fusion of sperm to egg plasma membrane (GO:0007342)13.2434509
152acrosome reaction (GO:0007340)12.6603910
153cell wall macromolecule catabolic process (GO:0016998)12.0925181
154cell wall macromolecule metabolic process (GO:0044036)12.0925181
155sperm-egg recognition (GO:0035036)11.4879729
156acrosome assembly (GO:0001675)10.8523070
157multicellular organism reproduction (GO:0032504)10.7441887
158melanin biosynthetic process (GO:0042438)10.6654254
159binding of sperm to zona pellucida (GO:0007339)10.4778615
160cell-cell recognition (GO:0009988)10.2786536
161epithelial cilium movement (GO:0003351)10.1782177
162plasma membrane fusion (GO:0045026)10.1113107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.91881248
2E2F7_22180533_ChIP-Seq_HELA_Human6.84397807
3EZH2_22144423_ChIP-Seq_EOC_Human4.49355796
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.06051017
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91400242
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77706653
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.51901063
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83231466
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78211432
10VDR_22108803_ChIP-Seq_LS180_Human2.68819498
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60610682
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57585715
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56515038
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43331623
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27694429
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21243883
17LXR_22292898_ChIP-Seq_THP-1_Human2.20345413
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14187109
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.12789509
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.12392034
21MYC_22102868_ChIP-Seq_BL_Human2.08095123
22SMC4_20622854_ChIP-Seq_HELA_Human2.06885572
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.98788833
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.98132470
25P68_20966046_ChIP-Seq_HELA_Human1.98065482
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92381637
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88468398
28ZNF274_21170338_ChIP-Seq_K562_Hela1.87695597
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87299456
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84906162
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81655966
32PHF8_20622854_ChIP-Seq_HELA_Human1.79793512
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77103104
34VDR_21846776_ChIP-Seq_THP-1_Human1.75945092
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.75869093
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74327057
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73985136
38FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73980683
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72940501
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72120513
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71488874
42XRN2_22483619_ChIP-Seq_HELA_Human1.69951568
43STAT1_17558387_ChIP-Seq_HELA_Human1.69505392
44KDM5A_27292631_Chip-Seq_BREAST_Human1.68357605
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66365233
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66153606
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65924806
48BCOR_27268052_Chip-Seq_Bcells_Human1.65769441
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62290578
50BCL6_27268052_Chip-Seq_Bcells_Human1.61716339
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61369954
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60402030
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.60373280
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.58126059
55CIITA_25753668_ChIP-Seq_RAJI_Human1.57342752
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.56496288
57RAC3_21632823_ChIP-Seq_H3396_Human1.54646431
58E2F1_20622854_ChIP-Seq_HELA_Human1.54097254
59GABP_19822575_ChIP-Seq_HepG2_Human1.54067769
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52999781
61GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50289534
62GATA3_21867929_ChIP-Seq_CD8_Mouse1.49064304
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47692703
64CBP_20019798_ChIP-Seq_JUKART_Human1.47692703
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47464665
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47139338
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46977057
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.43761249
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43670653
70FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42943752
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42765130
72KDM2B_26808549_Chip-Seq_REH_Human1.42185506
73REST_21632747_ChIP-Seq_MESCs_Mouse1.41134742
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40681431
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40020535
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.39909623
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39686909
78MAF_26560356_Chip-Seq_TH2_Human1.38847427
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.38840486
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.38227070
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37795112
82ERA_21632823_ChIP-Seq_H3396_Human1.37528530
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.36833184
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.35537996
85P53_21459846_ChIP-Seq_SAOS-2_Human1.34812848
86CTCF_21964334_Chip-Seq_Bcells_Human1.34280390
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.33881212
88DCP1A_22483619_ChIP-Seq_HELA_Human1.33537179
89TFEB_21752829_ChIP-Seq_HELA_Human1.32834711
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31831149
91TTF2_22483619_ChIP-Seq_HELA_Human1.31709241
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30806867
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28818076
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28611193
95KDM2B_26808549_Chip-Seq_DND41_Human1.26880830
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26606480
97TAF15_26573619_Chip-Seq_HEK293_Human1.26320677
98GATA3_21867929_ChIP-Seq_TH1_Mouse1.26030610
99* CTCF_27219007_Chip-Seq_Bcells_Human1.25065594
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24762183
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22288045
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22172970
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.21767294
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21417669
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21417669
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19838810
107GF1_26923725_Chip-Seq_HPCs_Mouse1.19227844
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.18797884
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18307312
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.18056479
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18019115
112P300_27268052_Chip-Seq_Bcells_Human1.17601870
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17103681
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17059513
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.16599009
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16471017
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16213969
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15923719
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15723475
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15314183
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13400637
122ERG_20517297_ChIP-Seq_VCAP_Human1.12639618
123SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12530504
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11962839
125SPI1_26923725_Chip-Seq_HPCs_Mouse1.11663515
126UTX_26944678_Chip-Seq_JUKART_Human1.11104773
127TP63_22573176_ChIP-Seq_HFKS_Human1.10527285
128MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09987987
129NCOR1_26117541_ChIP-Seq_K562_Human1.09984688
130MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09356544
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08519325
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08441537
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07557419
134MYC_27129775_Chip-Seq_CORNEA_Mouse1.06730234
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06163321
136SPI1_20517297_ChIP-Seq_HL60_Human1.05632638
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05191847
138AR_21909140_ChIP-Seq_LNCAP_Human1.05150257
139MITF_21258399_ChIP-Seq_MELANOMA_Human1.04787434
140E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04783361
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04699672
142PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04699472
143YY1_22570637_ChIP-Seq_MALME-3M_Human1.04210160
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04093858
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04034137
146SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03779544
147JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03167320
148CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02341027
149CTCF_20526341_ChIP-Seq_ESCs_Human1.02250934
150TET1_21451524_ChIP-Seq_MESCs_Mouse1.02134870
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01507580
152GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01496912
153FOXP3_21729870_ChIP-Seq_TREG_Human1.01332068
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.99488695
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99258191
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.98902017
157ETS1_21867929_ChIP-Seq_TH2_Mouse0.98807510
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.98408619
159ESET_19884257_ChIP-Seq_ESCs_Mouse0.98321894
160MYB_26560356_Chip-Seq_TH1_Human0.97828976
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96685942
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96663694
163SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95814682
164SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95374004
165TP53_22127205_ChIP-Seq_IMR90_Human0.94378222
166ELK3_25401928_ChIP-Seq_HUVEC_Human0.94245590
167RUNX1_27514584_Chip-Seq_MCF-7_Human0.94161112
168TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94054425
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93864368
170NFYB_21822215_ChIP-Seq_K562_Human0.93205564
171TCF7_22412390_ChIP-Seq_EML_Mouse0.93203761
172ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92971105
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.92278631
174TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92271454
175KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91744588
176NANOG_20526341_ChIP-Seq_ESCs_Human0.91251232
177SOX9_26525672_Chip-Seq_HEART_Mouse0.90255804
178PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90011472
179SMAD4_21741376_ChIP-Seq_EPCs_Human0.89925288
180FLI1_21867929_ChIP-Seq_CD8_Mouse0.89908224
181OCT4_18555785_Chip-Seq_ESCs_Mouse0.89333786
182SOX2_21211035_ChIP-Seq_LN229_Human0.89276430
183TBL1_22424771_ChIP-Seq_293T_Human0.89064347
184P53_22387025_ChIP-Seq_ESCs_Mouse0.88784694
185KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88452696
186LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87678952
187RNF2_27304074_Chip-Seq_NSC_Mouse0.87266656
188OCT1_27270436_Chip-Seq_PROSTATE_Human0.86365289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.87435178
2MP0005171_absent_coat_pigmentation6.02868819
3* MP0003698_abnormal_male_reproductive6.00093356
4MP0001929_abnormal_gametogenesis5.46888173
5MP0003136_yellow_coat_color5.42652815
6MP0005408_hypopigmentation4.37890065
7MP0000015_abnormal_ear_pigmentation4.05150857
8MP0008877_abnormal_DNA_methylation3.95528445
9MP0005075_abnormal_melanosome_morpholog3.46970027
10* MP0002161_abnormal_fertility/fecundity3.28446756
11MP0002210_abnormal_sex_determination3.28329328
12MP0004381_abnormal_hair_follicle3.13990933
13MP0005670_abnormal_white_adipose3.10993211
14MP0001145_abnormal_male_reproductive2.77698220
15MP0002877_abnormal_melanocyte_morpholog2.68102289
16MP0002095_abnormal_skin_pigmentation2.53079711
17MP0000371_diluted_coat_color2.52867918
18MP0002653_abnormal_ependyma_morphology2.48412877
19MP0000653_abnormal_sex_gland2.40229385
20MP0005174_abnormal_tail_pigmentation2.16056465
21MP0005410_abnormal_fertilization16.5395537
22MP0003077_abnormal_cell_cycle1.99944843
23MP0005257_abnormal_intraocular_pressure1.86250947
24MP0005248_abnormal_Harderian_gland1.74244244
25MP0002075_abnormal_coat/hair_pigmentati1.64812275
26MP0002938_white_spotting1.57662175
27MP0003693_abnormal_embryo_hatching1.51582370
28MP0003806_abnormal_nucleotide_metabolis1.49099634
29MP0005058_abnormal_lysosome_morphology1.48902818
30MP0002160_abnormal_reproductive_system1.47708144
31MP0008057_abnormal_DNA_replication1.45832167
32MP0003646_muscle_fatigue1.45087012
33MP0005623_abnormal_meninges_morphology1.43546394
34MP0002249_abnormal_larynx_morphology1.42744948
35MP0004957_abnormal_blastocyst_morpholog1.38830801
36MP0004233_abnormal_muscle_weight1.37859914
37MP0003718_maternal_effect1.31998167
38MP0002282_abnormal_trachea_morphology1.29244842
39MP0001186_pigmentation_phenotype1.29078499
40MP0008932_abnormal_embryonic_tissue1.25198398
41MP0001765_abnormal_ion_homeostasis1.20505282
42MP0001984_abnormal_olfaction1.15374057
43MP0005451_abnormal_body_composition1.15240879
44MP0000537_abnormal_urethra_morphology1.14056420
45MP0002132_abnormal_respiratory_system1.06740705
46MP0002822_catalepsy1.03749839
47MP0000678_abnormal_parathyroid_gland1.03588910
48MP0008995_early_reproductive_senescence1.01111621
49MP0003315_abnormal_perineum_morphology1.00060613
50MP0002090_abnormal_vision0.95667505
51MP0001348_abnormal_lacrimal_gland0.93845400
52MP0003172_abnormal_lysosome_physiology0.93438381
53MP0009046_muscle_twitch0.88803098
54MP0005647_abnormal_sex_gland0.84400495
55MP0002396_abnormal_hematopoietic_system0.81549299
56MP0003115_abnormal_respiratory_system0.80095384
57MP0008058_abnormal_DNA_repair0.76182599
58MP0003878_abnormal_ear_physiology0.75853724
59MP0005377_hearing/vestibular/ear_phenot0.75853724
60MP0004808_abnormal_hematopoietic_stem0.75600330
61MP0002234_abnormal_pharynx_morphology0.72531011
62MP0005389_reproductive_system_phenotype0.70826881
63MP0000569_abnormal_digit_pigmentation0.70289859
64MP0005636_abnormal_mineral_homeostasis0.70008085
65MP0005197_abnormal_uvea_morphology0.69634853
66MP0000003_abnormal_adipose_tissue0.68996323
67MP0002080_prenatal_lethality0.66618288
68MP0005409_darkened_coat_color0.66072416
69MP0001270_distended_abdomen0.65630802
70MP0009697_abnormal_copulation0.65404559
71MP0000350_abnormal_cell_proliferation0.65064182
72MP0010234_abnormal_vibrissa_follicle0.62370899
73MP0001764_abnormal_homeostasis0.61621596
74MP0003329_amyloid_beta_deposits0.61232485
75MP0002638_abnormal_pupillary_reflex0.59071631
76MP0000313_abnormal_cell_death0.57829145
77MP0005666_abnormal_adipose_tissue0.57537490
78MP0005187_abnormal_penis_morphology0.57014771
79MP0003011_delayed_dark_adaptation0.56875756
80MP0001324_abnormal_eye_pigmentation0.56578382
81MP0010307_abnormal_tumor_latency0.56290762
82MP0005367_renal/urinary_system_phenotyp0.55683142
83MP0000516_abnormal_urinary_system0.55683142
84MP0005380_embryogenesis_phenotype0.55408814
85MP0001672_abnormal_embryogenesis/_devel0.55408814
86MP0002736_abnormal_nociception_after0.55324234
87MP0002085_abnormal_embryonic_tissue0.51967301
88MP0000358_abnormal_cell_content/0.51744138
89MP0001293_anophthalmia0.51076557
90MP0001697_abnormal_embryo_size0.50106838
91MP0004036_abnormal_muscle_relaxation0.49766207
92MP0000534_abnormal_ureter_morphology0.48222634
93MP0003699_abnormal_female_reproductive0.47135854
94MP0005076_abnormal_cell_differentiation0.46462511
95MP0003385_abnormal_body_wall0.46461929
96MP0000681_abnormal_thyroid_gland0.45555206
97MP0003879_abnormal_hair_cell0.43916397
98MP0002269_muscular_atrophy0.43621922
99MP0005551_abnormal_eye_electrophysiolog0.43605803
100MP0002177_abnormal_outer_ear0.41926726
101MP0009115_abnormal_fat_cell0.41542570
102MP0004197_abnormal_fetal_growth/weight/0.40856203
103MP0002019_abnormal_tumor_incidence0.40469239
104MP0001545_abnormal_hematopoietic_system0.40122459
105MP0005397_hematopoietic_system_phenotyp0.40122459
106MP0002084_abnormal_developmental_patter0.40055044
107MP0005253_abnormal_eye_physiology0.39201632
108MP0010094_abnormal_chromosome_stability0.39018287
109MP0002928_abnormal_bile_duct0.38533065
110MP0003984_embryonic_growth_retardation0.38514135
111MP0003942_abnormal_urinary_system0.38083539
112MP0003950_abnormal_plasma_membrane0.36599301
113MP0006036_abnormal_mitochondrial_physio0.36516716
114MP0004811_abnormal_neuron_physiology0.36452830
115MP0001968_abnormal_touch/_nociception0.35058466
116MP0009278_abnormal_bone_marrow0.33587145
117MP0003787_abnormal_imprinting0.32745791
118MP0005391_vision/eye_phenotype0.31896462
119MP0004270_analgesia0.30140403
120MP0003786_premature_aging0.30067936
121MP0002971_abnormal_brown_adipose0.30040679
122MP0003633_abnormal_nervous_system0.29974520
123MP0000604_amyloidosis0.29678808
124MP0008961_abnormal_basal_metabolism0.28031701
125MP0003111_abnormal_nucleus_morphology0.27541920
126MP0004742_abnormal_vestibular_system0.27204659
127MP0002139_abnormal_hepatobiliary_system0.26357261
128MP0005365_abnormal_bile_salt0.26303548
129MP0002152_abnormal_brain_morphology0.26260410
130MP0001119_abnormal_female_reproductive0.26218131
131MP0003861_abnormal_nervous_system0.26168994
132MP0003631_nervous_system_phenotype0.24625166
133MP0003948_abnormal_gas_homeostasis0.23606436
134MP0002169_no_abnormal_phenotype0.23016197
135MP0002873_normal_phenotype0.22777819
136MP0000751_myopathy0.22650552
137MP0008569_lethality_at_weaning0.21764893
138MP0006035_abnormal_mitochondrial_morpho0.21758825
139MP0001849_ear_inflammation0.20537162
140MP0002572_abnormal_emotion/affect_behav0.20157866
141MP0001730_embryonic_growth_arrest0.19548147
142MP0001986_abnormal_taste_sensitivity0.19451645
143MP0004043_abnormal_pH_regulation0.18749210
144MP0002229_neurodegeneration0.18569347
145MP0002272_abnormal_nervous_system0.18231970
146MP0002092_abnormal_eye_morphology0.18182393
147MP0002063_abnormal_learning/memory/cond0.18102651
148MP0005375_adipose_tissue_phenotype0.17347028
149MP0004019_abnormal_vitamin_homeostasis0.17225243
150MP0008875_abnormal_xenobiotic_pharmacok0.17041571
151MP0005423_abnormal_somatic_nervous0.16993113
152MP0001727_abnormal_embryo_implantation0.16827338
153MP0004133_heterotaxia0.16304259
154MP0002909_abnormal_adrenal_gland0.15581793
155MP0001661_extended_life_span0.15210689
156MP0002102_abnormal_ear_morphology0.15074401
157MP0002295_abnormal_pulmonary_circulatio0.14915546
158MP0000001_mammalian_phenotype0.14659214
159MP0008007_abnormal_cellular_replicative0.14542102
160MP0009672_abnormal_birth_weight0.14411810
161MP0010329_abnormal_lipoprotein_level0.13975953
162MP0002118_abnormal_lipid_homeostasis0.13922796

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.20486652
2Abnormal respiratory epithelium morphology (HP:0012253)9.20486652
3Abnormal respiratory motile cilium physiology (HP:0012261)9.05218357
4Rhinitis (HP:0012384)7.23562450
5Abnormal ciliary motility (HP:0012262)7.14135875
6Infertility (HP:0000789)7.10477903
7Chronic bronchitis (HP:0004469)7.00401335
8Nasal polyposis (HP:0100582)6.26202259
9Ocular albinism (HP:0001107)5.99391924
10White forelock (HP:0002211)5.93316344
11Aplasia/Hypoplasia of the macula (HP:0008059)5.44324717
12Patchy hypopigmentation of hair (HP:0011365)5.18505666
13Male infertility (HP:0003251)5.15144097
14Abnormality of the nasal mucosa (HP:0000433)5.13565738
15Hypopigmentation of the fundus (HP:0007894)5.10219684
16Iris hypopigmentation (HP:0007730)5.02740236
17Aplasia/Hypoplasia affecting the retina (HP:0008061)5.01696893
18Blue irides (HP:0000635)4.75263440
19Bronchitis (HP:0012387)4.62788274
20Hypoplasia of the fovea (HP:0007750)4.34450525
21Aplasia/Hypoplasia of the fovea (HP:0008060)4.34450525
22Bronchiectasis (HP:0002110)4.33537078
23Nephronophthisis (HP:0000090)4.27185527
24Abnormality of the fovea (HP:0000493)3.95611741
25Abnormal spermatogenesis (HP:0008669)3.85647164
26Severe visual impairment (HP:0001141)3.71148489
27Albinism (HP:0001022)3.64830989
28Resting tremor (HP:0002322)3.54168294
29Cutaneous melanoma (HP:0012056)3.53952727
30Generalized hypopigmentation (HP:0007513)3.47187244
31Recurrent otitis media (HP:0000403)3.33437389
32Recurrent sinusitis (HP:0011108)3.26121883
33Abnormal auditory evoked potentials (HP:0006958)3.23970856
34Abnormality of the renal medulla (HP:0100957)3.22094466
35Premature graying of hair (HP:0002216)3.17687824
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.15341604
37Chromsome breakage (HP:0040012)3.11345289
38Tubulointerstitial nephritis (HP:0001970)3.05455654
39Recurrent bronchitis (HP:0002837)3.04379567
40Colitis (HP:0002583)2.93146544
41Impulsivity (HP:0100710)2.90355222
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83168632
43Freckling (HP:0001480)2.80373955
44Abnormal gallbladder physiology (HP:0012438)2.79526831
45Cholecystitis (HP:0001082)2.79526831
46Attenuation of retinal blood vessels (HP:0007843)2.72685430
47Abnormality of the columella (HP:0009929)2.70296901
48Spastic paraparesis (HP:0002313)2.59213928
49Morphological abnormality of the inner ear (HP:0011390)2.55956266
50Bony spicule pigmentary retinopathy (HP:0007737)2.54412106
51Abnormality of midbrain morphology (HP:0002418)2.51682385
52Molar tooth sign on MRI (HP:0002419)2.51682385
53Tubular atrophy (HP:0000092)2.51574896
54Congenital sensorineural hearing impairment (HP:0008527)2.47748680
55Tubulointerstitial abnormality (HP:0001969)2.46591328
56Gonadotropin excess (HP:0000837)2.45337077
57Abnormality of cochlea (HP:0000375)2.42257044
58Chronic hepatic failure (HP:0100626)2.40848725
59Self-mutilation (HP:0000742)2.38813382
60Medial flaring of the eyebrow (HP:0010747)2.35375513
61Aplasia/Hypoplasia of the earlobes (HP:0009906)2.33709181
62Renovascular hypertension (HP:0100817)2.30150022
63Hypoplasia of the iris (HP:0007676)2.30090631
64Azoospermia (HP:0000027)2.29408352
65Progressive sensorineural hearing impairment (HP:0000408)2.28499639
66Dyschromatopsia (HP:0007641)2.24920377
67Underdeveloped nasal alae (HP:0000430)2.23458917
68Hyperacusis (HP:0010780)2.22441920
69Spastic tetraparesis (HP:0001285)2.17693098
70Choroideremia (HP:0001139)2.15663378
71Small intestinal stenosis (HP:0012848)2.14703358
72Duodenal stenosis (HP:0100867)2.14703358
73Squamous cell carcinoma (HP:0002860)2.08764738
74Horizontal nystagmus (HP:0000666)2.07429106
75Cerebral hypomyelination (HP:0006808)2.06720914
76Decreased central vision (HP:0007663)2.06232951
77Heterochromia iridis (HP:0001100)2.03466662
78Reduced antithrombin III activity (HP:0001976)2.03151060
79Congenital stationary night blindness (HP:0007642)2.02487120
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.4866693
81Absent/shortened dynein arms (HP:0200106)13.4866693
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6964897
83Proximal placement of thumb (HP:0009623)1.99791160
84Amblyopia (HP:0000646)1.99026690
85Postural instability (HP:0002172)1.97699768
86Abnormal biliary tract physiology (HP:0012439)1.96725999
87Bile duct proliferation (HP:0001408)1.96725999
88Median cleft lip (HP:0000161)1.95455228
89Sloping forehead (HP:0000340)1.93728486
90Thoracic kyphosis (HP:0002942)1.91982679
91Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.91664485
92Peripheral hypomyelination (HP:0007182)1.89293078
93Hypoplasia of the thymus (HP:0000778)1.89162166
94Enlarged kidneys (HP:0000105)1.88621800
95Postaxial foot polydactyly (HP:0001830)1.88054832
96Ulnar bowing (HP:0003031)1.87919083
97Heterotopia (HP:0002282)1.87695521
98Tubulointerstitial fibrosis (HP:0005576)1.87443236
99Progressive hearing impairment (HP:0001730)1.83431856
100Germ cell neoplasia (HP:0100728)1.82044960
101Flared metaphyses (HP:0003015)1.81596781
102Abnormality of the carotid arteries (HP:0005344)1.79463262
103Deviation of the thumb (HP:0009603)1.78560569
104Hypergonadotropic hypogonadism (HP:0000815)1.77898880
105Hemorrhage of the eye (HP:0011885)1.75713996
106Abnormality of the ileum (HP:0001549)1.75476637
107Unilateral renal agenesis (HP:0000122)1.74667173
108Abnormal drinking behavior (HP:0030082)1.73619436
109Polydipsia (HP:0001959)1.73619436
110Bell-shaped thorax (HP:0001591)1.72694134
111Stage 5 chronic kidney disease (HP:0003774)1.71239522
112Increased nuchal translucency (HP:0010880)1.71172474
113Abnormality of chromosome stability (HP:0003220)1.70340927
114Congenital hepatic fibrosis (HP:0002612)1.68684874
115Abnormality of DNA repair (HP:0003254)1.67946815
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67423850
117Short ribs (HP:0000773)1.65320497
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.64465131
119Upper limb muscle weakness (HP:0003484)1.63800075
120Hypoalphalipoproteinemia (HP:0003233)1.63681758
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62939559
122Abnormality of the renal cortex (HP:0011035)1.62046790
123Atelectasis (HP:0100750)1.61975447
124Abnormality of the left ventricular outflow tract (HP:0011103)1.61895227
125Subaortic stenosis (HP:0001682)1.61895227
126Abnormal number of incisors (HP:0011064)1.61672330
127Meckel diverticulum (HP:0002245)1.60728394
128Abnormality of renal excretion (HP:0011036)1.60277702
129Insidious onset (HP:0003587)1.59666156
130Termporal pattern (HP:0011008)1.59666156
131Neurofibrillary tangles (HP:0002185)1.57624001
132Asymmetric septal hypertrophy (HP:0001670)1.56363564
133Abnormality of the lower motor neuron (HP:0002366)1.55477687
134Oculomotor apraxia (HP:0000657)1.53988822
135Fibular hypoplasia (HP:0003038)1.48072137
136Abnormality of dentin (HP:0010299)1.47518338
137Postaxial hand polydactyly (HP:0001162)1.46348585
138Hemiparesis (HP:0001269)1.45947268
139Renal dysplasia (HP:0000110)1.43949505
140Abnormality of permanent molar morphology (HP:0011071)1.43899800
141Abnormality of the dental root (HP:0006486)1.43899800
142Taurodontia (HP:0000679)1.43899800
143Aplasia/Hypoplasia of the lens (HP:0008063)1.43884550
144Bundle branch block (HP:0011710)1.41362343
145Cystic liver disease (HP:0006706)1.40688497
146Deformed sella turcica (HP:0002681)1.39303463
147Abnormal urine output (HP:0012590)1.38417348
148Constricted visual fields (HP:0001133)1.35790949
149Hypercholesterolemia (HP:0003124)1.35346479
150Double outlet right ventricle (HP:0001719)1.34719332
151Congenital malformation of the right heart (HP:0011723)1.34719332
152Abnormality of the dental pulp (HP:0006479)1.34438527
153Truncal obesity (HP:0001956)1.33291418
154Facial cleft (HP:0002006)1.31581024
155Abnormality of molar morphology (HP:0011070)1.31390466
156Abnormality of molar (HP:0011077)1.31390466
157Cerebral inclusion bodies (HP:0100314)1.31372770
158Sensory axonal neuropathy (HP:0003390)1.31019198
159Exercise-induced myalgia (HP:0003738)1.29628784
160Broad distal phalanx of finger (HP:0009836)1.28843481
161Amyotrophic lateral sclerosis (HP:0007354)1.28777698
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.26757664
163Absent epiphyses (HP:0010577)1.26757664
164Easy fatigability (HP:0003388)1.26094320
165Pancreatic fibrosis (HP:0100732)1.25643872
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24262443
167Gait imbalance (HP:0002141)1.23374706
168Myoglobinuria (HP:0002913)1.23231354
169Congenital primary aphakia (HP:0007707)1.22916228
170Absent frontal sinuses (HP:0002688)1.22674317
171Nephropathy (HP:0000112)1.21484791
172Neoplasm of the heart (HP:0100544)1.20610627
173Loss of speech (HP:0002371)1.18840934
174Chronic sinusitis (HP:0011109)1.18753077
175Short thorax (HP:0010306)1.18325455
176Lissencephaly (HP:0001339)1.18279122
177Fatigable weakness (HP:0003473)1.15723237
178Abnormality of the neuromuscular junction (HP:0003398)1.15723237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.98256536
2PDK37.98256536
3TESK16.39906555
4PRKD35.59010835
5PDK25.13293767
6ICK4.78386550
7MARK33.84733882
8TRIB32.44074493
9MST1R2.35470638
10PTK2B2.21920211
11ZAK2.16873550
12BRD42.16069443
13PNCK2.14100309
14WNK42.09957142
15CDK72.00133736
16STK391.91022271
17DYRK1B1.82309744
18CDK81.77153025
19PLK21.77042041
20STK381.74481428
21LATS11.68455141
22DDR21.64818351
23SMG11.54812680
24TLK11.54315002
25NME21.54283134
26NEK21.43847933
27CDK41.25604747
28BUB11.23330846
29MAPK111.20820369
30GRK61.20074811
31PDK11.18337987
32RPS6KA51.16546709
33SRPK11.16441743
34CSNK1A1L1.09878417
35PIM21.01598869
36DYRK30.92327582
37CSNK1G30.91191552
38TYRO30.91043402
39SCYL20.90569468
40MAP2K20.89291463
41MAPK150.88529063
42WNK10.84950962
43EIF2AK10.79615114
44CCNB10.77286890
45CAMK1D0.77111667
46BMPR1B0.75259532
47MAP2K60.74454247
48IRAK10.73959544
49PDPK10.72207396
50CDK90.69301064
51CAMK1G0.67907443
52MAP3K80.65717803
53RIPK40.65031828
54AKT20.64446574
55PASK0.62582060
56VRK10.61036221
57AURKA0.60172832
58SIK20.59762461
59INSRR0.58997842
60EEF2K0.58070019
61PINK10.55616104
62STK30.52907395
63CHEK20.52306882
64TESK20.52057224
65NTRK20.51684142
66TTK0.51647393
67TRIM280.51458359
68CSNK1G10.50127804
69AURKB0.49630912
70MAP4K20.48296333
71EIF2AK30.46348788
72CSNK1G20.45982428
73LMTK20.45790055
74MAP4K10.43698626
75PAK10.43562731
76KDR0.43514063
77FGR0.41986985
78IRAK20.41610494
79MET0.41534785
80NME10.40583329
81PRKCG0.40215470
82PKN20.38492861
83CHEK10.38425629
84PLK30.37247087
85STK38L0.36889626
86PRKCH0.36885472
87MUSK0.34788191
88MAPK100.33216833
89MAPK140.31561648
90RAF10.31101401
91PAK20.31068550
92MAP3K100.30373706
93PAK40.29386755
94MTOR0.28909700
95NEK60.28588432
96PRKAA20.28020262
97MARK20.27808774
98AKT10.26907527
99MELK0.26772428
100ATM0.26682090
101MAP3K10.26473410
102ATR0.24511406
103LATS20.21816007
104PLK40.21180255
105CAMKK10.21142446
106PRKAA10.20888795
107PRKCZ0.19762703
108CDK150.18433998
109MAPKAPK50.17496726
110CDK180.16925217
111RPS6KB10.16469480
112WEE10.15755280
113CDK11A0.14341656
114PRKCQ0.12344859
115CDC70.10841971
116GSK3B0.09927962
117CDK140.09775449
118MARK10.09593748
119BRAF0.08915912
120PLK10.07514677
121MAP3K40.06873166
122RPS6KA10.06532149
123BRSK10.06377557
124BRSK20.06036837
125CSNK2A10.06014984
126CLK10.05699629
127CSNK1D0.05130181
128PRKG20.03995457
129WNK30.03988664
130CSF1R0.03646464
131CDK20.03623809
132CDK10.03613424
133PRKCB0.03367881
134CAMK2A0.02915440
135MAPK80.02897730
136PRKG10.02253578
137CDK60.02062810
138PRKCD0.02032974
139PRKACG0.01473111
140YES10.01228043
141CDK30.00966628
142CSNK2A20.00818226
143PRKCA0.00647179
144STK110.00587839
145PAK60.00146483
146PRKDC-0.0354430
147MAPK1-0.0319400
148EGFR-0.0303297
149PRKACA-0.0280478
150CAMK1-0.0245795
151CDK12-0.0133126
152PRKACB-0.0127701
153MAP2K7-0.0125689
154PIM1-0.0124006
155RPS6KA3-0.0117471
156MAP3K5-0.0074999

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.82259004
2* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.69901406
3Pyruvate metabolism_Homo sapiens_hsa006203.41827252
4DNA replication_Homo sapiens_hsa030303.25614423
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.15596174
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.08331811
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98257226
8Vitamin B6 metabolism_Homo sapiens_hsa007502.93778494
9Linoleic acid metabolism_Homo sapiens_hsa005912.84412881
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64368762
11Non-homologous end-joining_Homo sapiens_hsa034502.59005165
12Glucagon signaling pathway_Homo sapiens_hsa049222.53978511
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.53409113
14Propanoate metabolism_Homo sapiens_hsa006402.51775303
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27321519
16Base excision repair_Homo sapiens_hsa034102.27233779
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.18496984
18Mismatch repair_Homo sapiens_hsa034302.14602855
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12957447
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.07225439
21Homologous recombination_Homo sapiens_hsa034402.05105298
22Basal transcription factors_Homo sapiens_hsa030221.99954967
23Glycerolipid metabolism_Homo sapiens_hsa005611.99173232
24Fructose and mannose metabolism_Homo sapiens_hsa000511.95784076
25Cell cycle_Homo sapiens_hsa041101.91981290
26PPAR signaling pathway_Homo sapiens_hsa033201.89716595
27One carbon pool by folate_Homo sapiens_hsa006701.88850234
28Selenocompound metabolism_Homo sapiens_hsa004501.81888555
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.75712727
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.72770336
31Tyrosine metabolism_Homo sapiens_hsa003501.72327296
32Spliceosome_Homo sapiens_hsa030401.71063902
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67387503
34Dorso-ventral axis formation_Homo sapiens_hsa043201.61466825
35Nucleotide excision repair_Homo sapiens_hsa034201.60331451
36Other glycan degradation_Homo sapiens_hsa005111.60133369
37Oocyte meiosis_Homo sapiens_hsa041141.57321741
38Fatty acid metabolism_Homo sapiens_hsa012121.56916107
39Fatty acid degradation_Homo sapiens_hsa000711.54401732
40Mineral absorption_Homo sapiens_hsa049781.52584665
41Sulfur relay system_Homo sapiens_hsa041221.51023505
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.49717368
43Amphetamine addiction_Homo sapiens_hsa050311.48238200
44Carbon metabolism_Homo sapiens_hsa012001.45829489
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42499473
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37834330
47Fat digestion and absorption_Homo sapiens_hsa049751.37536930
48Pentose phosphate pathway_Homo sapiens_hsa000301.37246473
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33651964
50Arginine biosynthesis_Homo sapiens_hsa002201.32774609
51Lysine degradation_Homo sapiens_hsa003101.32690469
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.28415419
53Ether lipid metabolism_Homo sapiens_hsa005651.23069680
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22777364
55Antigen processing and presentation_Homo sapiens_hsa046121.22276285
56Cardiac muscle contraction_Homo sapiens_hsa042601.21402530
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.20023458
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19542273
59Collecting duct acid secretion_Homo sapiens_hsa049661.08918931
60Apoptosis_Homo sapiens_hsa042101.08389966
61Renin secretion_Homo sapiens_hsa049241.07575463
62mRNA surveillance pathway_Homo sapiens_hsa030151.06764377
63Fanconi anemia pathway_Homo sapiens_hsa034601.02294448
64Purine metabolism_Homo sapiens_hsa002301.02168997
65Insulin secretion_Homo sapiens_hsa049111.00496920
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99507085
67Biosynthesis of amino acids_Homo sapiens_hsa012300.98239898
68Viral carcinogenesis_Homo sapiens_hsa052030.97259569
69Hedgehog signaling pathway_Homo sapiens_hsa043400.96805327
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96217528
71Prostate cancer_Homo sapiens_hsa052150.94866687
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94371163
73Phenylalanine metabolism_Homo sapiens_hsa003600.92346368
74Huntingtons disease_Homo sapiens_hsa050160.91033187
75Herpes simplex infection_Homo sapiens_hsa051680.90692071
76Butanoate metabolism_Homo sapiens_hsa006500.89517436
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89066008
78Thyroid cancer_Homo sapiens_hsa052160.87174080
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84548003
80RNA transport_Homo sapiens_hsa030130.84349262
81Arginine and proline metabolism_Homo sapiens_hsa003300.83197496
82Bile secretion_Homo sapiens_hsa049760.82554656
83Glutathione metabolism_Homo sapiens_hsa004800.81933968
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.81608386
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80862307
86Synaptic vesicle cycle_Homo sapiens_hsa047210.80068583
87Thyroid hormone synthesis_Homo sapiens_hsa049180.80033182
88Estrogen signaling pathway_Homo sapiens_hsa049150.79914415
89Chemical carcinogenesis_Homo sapiens_hsa052040.75827674
90Small cell lung cancer_Homo sapiens_hsa052220.75483613
91Non-small cell lung cancer_Homo sapiens_hsa052230.74278798
92RNA degradation_Homo sapiens_hsa030180.73995365
93Long-term potentiation_Homo sapiens_hsa047200.73781393
94Arachidonic acid metabolism_Homo sapiens_hsa005900.71400855
95p53 signaling pathway_Homo sapiens_hsa041150.71353056
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70923519
97Legionellosis_Homo sapiens_hsa051340.69931752
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69046098
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68812033
100Acute myeloid leukemia_Homo sapiens_hsa052210.66804477
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66702757
102RNA polymerase_Homo sapiens_hsa030200.66491428
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66225626
104Salivary secretion_Homo sapiens_hsa049700.64318360
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.61914358
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61664445
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61191841
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60660981
109mTOR signaling pathway_Homo sapiens_hsa041500.57967959
110Calcium signaling pathway_Homo sapiens_hsa040200.56649998
111Renin-angiotensin system_Homo sapiens_hsa046140.56529102
112Sphingolipid metabolism_Homo sapiens_hsa006000.56329194
113Pancreatic secretion_Homo sapiens_hsa049720.56128491
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55769686
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54609690
116ABC transporters_Homo sapiens_hsa020100.52673824
117Gap junction_Homo sapiens_hsa045400.52260109
118Taste transduction_Homo sapiens_hsa047420.51934334
119Protein digestion and absorption_Homo sapiens_hsa049740.49390541
120Gastric acid secretion_Homo sapiens_hsa049710.48987728
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48319662
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47733400
123Endocytosis_Homo sapiens_hsa041440.47601270
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47442178
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47391372
126Inositol phosphate metabolism_Homo sapiens_hsa005620.45878917
127Melanogenesis_Homo sapiens_hsa049160.45733408
128Circadian entrainment_Homo sapiens_hsa047130.45308137
129Epstein-Barr virus infection_Homo sapiens_hsa051690.43396882
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42746326
131AMPK signaling pathway_Homo sapiens_hsa041520.42594911
132Bladder cancer_Homo sapiens_hsa052190.41454987
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39942341
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.39544744
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39184710
136Nitrogen metabolism_Homo sapiens_hsa009100.37320754
137Galactose metabolism_Homo sapiens_hsa000520.36560951
138cAMP signaling pathway_Homo sapiens_hsa040240.34776684
139Hepatitis B_Homo sapiens_hsa051610.34061716
140MicroRNAs in cancer_Homo sapiens_hsa052060.33815322
141Sulfur metabolism_Homo sapiens_hsa009200.33595393
142Insulin signaling pathway_Homo sapiens_hsa049100.33271469
143* Metabolic pathways_Homo sapiens_hsa011000.30876228
144Choline metabolism in cancer_Homo sapiens_hsa052310.30208247
145Pyrimidine metabolism_Homo sapiens_hsa002400.29292054
146Cocaine addiction_Homo sapiens_hsa050300.25295551
147VEGF signaling pathway_Homo sapiens_hsa043700.24548707
148Systemic lupus erythematosus_Homo sapiens_hsa053220.19738288
149Alcoholism_Homo sapiens_hsa050340.15008881
150N-Glycan biosynthesis_Homo sapiens_hsa005100.14671620
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13650057
152Glutamatergic synapse_Homo sapiens_hsa047240.11048067
153Type II diabetes mellitus_Homo sapiens_hsa049300.10961286
154Basal cell carcinoma_Homo sapiens_hsa052170.10568711
155Wnt signaling pathway_Homo sapiens_hsa043100.08101118
156Nicotine addiction_Homo sapiens_hsa050330.07653072
157Olfactory transduction_Homo sapiens_hsa047400.07600420

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