

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | leukocyte aggregation (GO:0070486) | 7.35464098 |
| 2 | neutrophil activation involved in immune response (GO:0002283) | 6.44975458 |
| 3 | respiratory burst (GO:0045730) | 6.13143304 |
| 4 | cellular extravasation (GO:0045123) | 6.08187388 |
| 5 | neutrophil mediated immunity (GO:0002446) | 5.99692947 |
| 6 | response to peptidoglycan (GO:0032494) | 5.87034861 |
| 7 | leukocyte migration involved in inflammatory response (GO:0002523) | 5.78148315 |
| 8 | defense response to fungus (GO:0050832) | 5.68689111 |
| 9 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.62515763 |
| 10 | response to fungus (GO:0009620) | 5.59455409 |
| 11 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 5.53460792 |
| 12 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 5.53460792 |
| 13 | neutrophil activation (GO:0042119) | 5.31790090 |
| 14 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.27904159 |
| 15 | negative regulation of phagocytosis (GO:0050765) | 5.25007652 |
| 16 | production of molecular mediator involved in inflammatory response (GO:0002532) | 5.18146743 |
| 17 | granulocyte activation (GO:0036230) | 4.88606577 |
| 18 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 4.72580328 |
| 19 | superoxide anion generation (GO:0042554) | 4.58527073 |
| 20 | myeloid leukocyte mediated immunity (GO:0002444) | 4.46406437 |
| 21 | sequestering of metal ion (GO:0051238) | 4.39847606 |
| 22 | regulation of mast cell activation (GO:0033003) | 4.39751367 |
| 23 | positive regulation of mast cell activation (GO:0033005) | 4.38829926 |
| 24 | detection of external biotic stimulus (GO:0098581) | 4.35503834 |
| 25 | microglial cell activation (GO:0001774) | 4.27255792 |
| 26 | regulation of mast cell degranulation (GO:0043304) | 4.26605739 |
| 27 | regulation of gamma-delta T cell activation (GO:0046643) | 4.26565121 |
| 28 | detection of molecule of bacterial origin (GO:0032490) | 4.24801935 |
| 29 | reactive oxygen species biosynthetic process (GO:1903409) | 4.18372515 |
| 30 | macrophage differentiation (GO:0030225) | 4.15117330 |
| 31 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 4.12751365 |
| 32 | disruption of cells of other organism (GO:0044364) | 4.05597584 |
| 33 | killing of cells of other organism (GO:0031640) | 4.05597584 |
| 34 | pentose-phosphate shunt (GO:0006098) | 4.02348180 |
| 35 | leukocyte mediated cytotoxicity (GO:0001909) | 4.01428097 |
| 36 | regulation of leukocyte degranulation (GO:0043300) | 4.00663758 |
| 37 | leukotriene metabolic process (GO:0006691) | 3.96895136 |
| 38 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.92647146 |
| 39 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.91168199 |
| 40 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.90777350 |
| 41 | positive regulation of mast cell degranulation (GO:0043306) | 3.90777350 |
| 42 | detection of biotic stimulus (GO:0009595) | 3.88597448 |
| 43 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.88080155 |
| 44 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.86971548 |
| 45 | immunoglobulin mediated immune response (GO:0016064) | 3.85912533 |
| 46 | regulation of B cell differentiation (GO:0045577) | 3.81094252 |
| 47 | leukotriene biosynthetic process (GO:0019370) | 3.75812674 |
| 48 | detection of other organism (GO:0098543) | 3.74788039 |
| 49 | negative regulation of cell killing (GO:0031342) | 3.74486132 |
| 50 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.74486132 |
| 51 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.72571941 |
| 52 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.72571941 |
| 53 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.72571941 |
| 54 | modulation by symbiont of host immune response (GO:0052553) | 3.72571941 |
| 55 | positive regulation by symbiont of host defense response (GO:0052509) | 3.72571941 |
| 56 | modulation by symbiont of host defense response (GO:0052031) | 3.72571941 |
| 57 | positive thymic T cell selection (GO:0045059) | 3.71601034 |
| 58 | neutrophil chemotaxis (GO:0030593) | 3.69102603 |
| 59 | B cell receptor signaling pathway (GO:0050853) | 3.66437105 |
| 60 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.65397155 |
| 61 | NADPH regeneration (GO:0006740) | 3.63233329 |
| 62 | cellular response to zinc ion (GO:0071294) | 3.61221986 |
| 63 | leukocyte degranulation (GO:0043299) | 3.59769293 |
| 64 | detection of bacterium (GO:0016045) | 3.59108132 |
| 65 | neutrophil migration (GO:1990266) | 3.58733985 |
| 66 | macrophage activation (GO:0042116) | 3.58021303 |
| 67 | negative regulation of mast cell activation (GO:0033004) | 3.56273786 |
| 68 | myeloid cell activation involved in immune response (GO:0002275) | 3.53644822 |
| 69 | actin nucleation (GO:0045010) | 3.49298615 |
| 70 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.47865434 |
| 71 | regulation of growth of symbiont in host (GO:0044126) | 3.45301559 |
| 72 | negative regulation of growth of symbiont in host (GO:0044130) | 3.45301559 |
| 73 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 3.45301559 |
| 74 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 3.45301559 |
| 75 | positive regulation of B cell differentiation (GO:0045579) | 3.44426181 |
| 76 | defense response to protozoan (GO:0042832) | 3.44021069 |
| 77 | lipoxygenase pathway (GO:0019372) | 3.42759791 |
| 78 | regulation of regulated secretory pathway (GO:1903305) | 3.41523276 |
| 79 | negative regulation of T cell mediated immunity (GO:0002710) | 3.40957313 |
| 80 | positive regulation of lamellipodium assembly (GO:0010592) | 3.40916652 |
| 81 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.40700178 |
| 82 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.39792866 |
| 83 | regulation of antigen processing and presentation (GO:0002577) | 3.34526066 |
| 84 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.33827287 |
| 85 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.33085825 |
| 86 | response to interleukin-15 (GO:0070672) | 3.32480430 |
| 87 | leukocyte cell-cell adhesion (GO:0007159) | 3.31844751 |
| 88 | response to host immune response (GO:0052572) | 3.31654080 |
| 89 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.31654080 |
| 90 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.28598709 |
| 91 | mast cell activation (GO:0045576) | 3.28124744 |
| 92 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.27873675 |
| 93 | negative thymic T cell selection (GO:0045060) | 3.27169315 |
| 94 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.26256131 |
| 95 | response to muramyl dipeptide (GO:0032495) | 3.26138153 |
| 96 | positive regulation of granulocyte differentiation (GO:0030854) | 3.24925592 |
| 97 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.24422282 |
| 98 | granulocyte migration (GO:0097530) | 3.19051720 |
| 99 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.18273783 |
| 100 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.18273783 |
| 101 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.17965030 |
| 102 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.14425916 |
| 103 | positive regulation of antigen processing and presentation (GO:0002579) | 3.14008643 |
| 104 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.13497803 |
| 105 | negative T cell selection (GO:0043383) | 3.13070784 |
| 106 | macrophage activation involved in immune response (GO:0002281) | 3.11778484 |
| 107 | response to protozoan (GO:0001562) | 3.10873028 |
| 108 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.10442123 |
| 109 | granulocyte chemotaxis (GO:0071621) | 3.09465005 |
| 110 | cell killing (GO:0001906) | 3.08006395 |
| 111 | positive T cell selection (GO:0043368) | 3.06561906 |
| 112 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.05622524 |
| 113 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.05622524 |
| 114 | positive regulation of interferon-alpha production (GO:0032727) | 3.05467720 |
| 115 | negative regulation of alpha-beta T cell activation (GO:0046636) | 3.03806493 |
| 116 | B cell mediated immunity (GO:0019724) | 3.03409828 |
| 117 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.02617082 |
| 118 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.01167989 |
| 119 | response to host (GO:0075136) | 3.01167989 |
| 120 | response to host defenses (GO:0052200) | 3.01167989 |
| 121 | cellular response to type I interferon (GO:0071357) | 3.00504766 |
| 122 | type I interferon signaling pathway (GO:0060337) | 3.00504766 |
| 123 | response to type I interferon (GO:0034340) | 2.99331656 |
| 124 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.98795335 |
| 125 | regulation of tolerance induction (GO:0002643) | 2.98388728 |
| 126 | dendritic cell migration (GO:0036336) | 2.98204677 |
| 127 | cellular response to interleukin-15 (GO:0071350) | 2.97780361 |
| 128 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.97552220 |
| 129 | positive regulation of leukocyte degranulation (GO:0043302) | 2.93785379 |
| 130 | positive regulation of lamellipodium organization (GO:1902745) | 2.91451707 |
| 131 | negative regulation of interleukin-12 production (GO:0032695) | 2.88845966 |
| 132 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.88569097 |
| 133 | negative regulation of B cell proliferation (GO:0030889) | 2.88026673 |
| 134 | T cell migration (GO:0072678) | 2.87604990 |
| 135 | regulation of interferon-alpha production (GO:0032647) | 2.87027339 |
| 136 | dendritic cell chemotaxis (GO:0002407) | 2.86371975 |
| 137 | phagosome maturation (GO:0090382) | 2.85949723 |
| 138 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.79621537 |
| 139 | mast cell degranulation (GO:0043303) | 2.78966290 |
| 140 | mast cell activation involved in immune response (GO:0002279) | 2.78966290 |
| 141 | pentose metabolic process (GO:0019321) | 2.78044770 |
| 142 | regulation of B cell apoptotic process (GO:0002902) | 2.77743168 |
| 143 | angiogenesis involved in wound healing (GO:0060055) | 2.77289293 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.58929852 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.89493681 |
| 3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.67475636 |
| 4 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 4.07785123 |
| 5 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 4.02134646 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.80193206 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.54880941 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.54529976 |
| 9 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.22382176 |
| 10 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.16860246 |
| 11 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.06723124 |
| 12 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.96122597 |
| 13 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.93654910 |
| 14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.91670008 |
| 15 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.85537969 |
| 16 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.84407261 |
| 17 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.71710093 |
| 18 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.64511132 |
| 19 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.62022827 |
| 20 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.56082788 |
| 21 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.51862973 |
| 22 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.31780664 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.28529186 |
| 24 | MYC_22102868_ChIP-Seq_BL_Human | 2.21972418 |
| 25 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.20566986 |
| 26 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.14804576 |
| 27 | MYB_26560356_Chip-Seq_TH2_Human | 2.09936500 |
| 28 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.07251680 |
| 29 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.03190264 |
| 30 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.02175037 |
| 31 | MAF_26560356_Chip-Seq_TH1_Human | 1.97418585 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.96296717 |
| 33 | SPI1_23127762_ChIP-Seq_K562_Human | 1.91584014 |
| 34 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.86920273 |
| 35 | MYB_26560356_Chip-Seq_TH1_Human | 1.85967872 |
| 36 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.84073827 |
| 37 | UTX_26944678_Chip-Seq_JUKART_Human | 1.83504357 |
| 38 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81658576 |
| 39 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.77753313 |
| 40 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77143418 |
| 41 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.76119325 |
| 42 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.74644083 |
| 43 | GATA1_22025678_ChIP-Seq_K562_Human | 1.65169085 |
| 44 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.60788196 |
| 45 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.60530216 |
| 46 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.57410942 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.54962971 |
| 48 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.51359434 |
| 49 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.50989759 |
| 50 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.44856756 |
| 51 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44701860 |
| 52 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.41598832 |
| 53 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.41234617 |
| 54 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.39983266 |
| 55 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.39576799 |
| 56 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.38477871 |
| 57 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.37056536 |
| 58 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.35756249 |
| 59 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.35123129 |
| 60 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.34226588 |
| 61 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.31555376 |
| 62 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.30584236 |
| 63 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.29572984 |
| 64 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.29422832 |
| 65 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.24340074 |
| 66 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.22376382 |
| 67 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.22289979 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.21868687 |
| 69 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.20124555 |
| 70 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.18493468 |
| 71 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14073889 |
| 72 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12075742 |
| 73 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.11246523 |
| 74 | GATA3_26560356_Chip-Seq_TH2_Human | 1.08969309 |
| 75 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.08075215 |
| 76 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.07805058 |
| 77 | MAF_26560356_Chip-Seq_TH2_Human | 1.07399768 |
| 78 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.07116491 |
| 79 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.06609367 |
| 80 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.06289131 |
| 81 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.06175387 |
| 82 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.05698400 |
| 83 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.04460825 |
| 84 | GATA1_19941826_ChIP-Seq_K562_Human | 1.03524245 |
| 85 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03278401 |
| 86 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.99445595 |
| 87 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99080681 |
| 88 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.97737712 |
| 89 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.94195933 |
| 90 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.92939567 |
| 91 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92672797 |
| 92 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.91576932 |
| 93 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.91291574 |
| 94 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.88793515 |
| 95 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.87537825 |
| 96 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.85622579 |
| 97 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.84378181 |
| 98 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.83739791 |
| 99 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.83447215 |
| 100 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.82142057 |
| 101 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.81648685 |
| 102 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.81245031 |
| 103 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.78129134 |
| 104 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.77980187 |
| 105 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.76711855 |
| 106 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.76709648 |
| 107 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.75406884 |
| 108 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.75340019 |
| 109 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.75054481 |
| 110 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.74027685 |
| 111 | * ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.73139620 |
| 112 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73088652 |
| 113 | P300_27268052_Chip-Seq_Bcells_Human | 0.72918739 |
| 114 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.72493219 |
| 115 | GATA3_26560356_Chip-Seq_TH1_Human | 0.72389325 |
| 116 | GATA2_19941826_ChIP-Seq_K562_Human | 0.70661996 |
| 117 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.70202912 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003303_peritoneal_inflammation | 4.93081341 |
| 2 | MP0003436_decreased_susceptibility_to | 4.38438731 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.82105570 |
| 4 | MP0002419_abnormal_innate_immunity | 3.40935473 |
| 5 | MP0009785_altered_susceptibility_to | 3.24875153 |
| 6 | MP0003183_abnormal_peptide_metabolism | 3.03113918 |
| 7 | MP0005025_abnormal_response_to | 2.89349299 |
| 8 | MP0005000_abnormal_immune_tolerance | 2.73129805 |
| 9 | MP0005464_abnormal_platelet_physiology | 2.64265058 |
| 10 | * MP0002452_abnormal_antigen_presenting | 2.56632332 |
| 11 | * MP0001800_abnormal_humoral_immune | 2.55067747 |
| 12 | MP0002148_abnormal_hypersensitivity_rea | 2.54580709 |
| 13 | * MP0002420_abnormal_adaptive_immunity | 2.44507113 |
| 14 | * MP0001819_abnormal_immune_cell | 2.43189293 |
| 15 | MP0000685_abnormal_immune_system | 2.41905751 |
| 16 | MP0009278_abnormal_bone_marrow | 2.39859213 |
| 17 | MP0005387_immune_system_phenotype | 2.39246932 |
| 18 | MP0001790_abnormal_immune_system | 2.39246932 |
| 19 | * MP0002723_abnormal_immune_serum | 2.31707526 |
| 20 | MP0002396_abnormal_hematopoietic_system | 2.24849465 |
| 21 | MP0001853_heart_inflammation | 2.14067416 |
| 22 | MP0002405_respiratory_system_inflammati | 2.13845104 |
| 23 | MP0000465_gastrointestinal_hemorrhage | 2.09922879 |
| 24 | MP0001533_abnormal_skeleton_physiology | 2.06282195 |
| 25 | MP0005671_abnormal_response_to | 2.06258129 |
| 26 | * MP0002398_abnormal_bone_marrow | 2.05360485 |
| 27 | MP0004808_abnormal_hematopoietic_stem | 2.03167535 |
| 28 | MP0001545_abnormal_hematopoietic_system | 2.02972762 |
| 29 | MP0005397_hematopoietic_system_phenotyp | 2.02972762 |
| 30 | MP0003724_increased_susceptibility_to | 1.95856308 |
| 31 | * MP0000716_abnormal_immune_system | 1.95198241 |
| 32 | MP0001845_abnormal_inflammatory_respons | 1.93334867 |
| 33 | MP0000343_altered_response_to | 1.81529357 |
| 34 | MP0003300_gastrointestinal_ulcer | 1.78472674 |
| 35 | MP0005058_abnormal_lysosome_morphology | 1.76231183 |
| 36 | MP0003172_abnormal_lysosome_physiology | 1.71330573 |
| 37 | MP0010155_abnormal_intestine_physiology | 1.69257742 |
| 38 | MP0010307_abnormal_tumor_latency | 1.68367744 |
| 39 | * MP0002429_abnormal_blood_cell | 1.68172208 |
| 40 | MP0002722_abnormal_immune_system | 1.65720811 |
| 41 | * MP0000689_abnormal_spleen_morphology | 1.64718985 |
| 42 | MP0003693_abnormal_embryo_hatching | 1.64155916 |
| 43 | MP0000858_altered_metastatic_potential | 1.59840233 |
| 44 | MP0001851_eye_inflammation | 1.55501071 |
| 45 | MP0002166_altered_tumor_susceptibility | 1.42817691 |
| 46 | MP0005174_abnormal_tail_pigmentation | 1.41968537 |
| 47 | MP0003075_altered_response_to | 1.41292700 |
| 48 | MP0005075_abnormal_melanosome_morpholog | 1.39648974 |
| 49 | MP0008469_abnormal_protein_level | 1.36024836 |
| 50 | MP0000490_abnormal_crypts_of | 1.35533996 |
| 51 | MP0009764_decreased_sensitivity_to | 1.34454187 |
| 52 | MP0010094_abnormal_chromosome_stability | 1.30741431 |
| 53 | MP0003111_abnormal_nucleus_morphology | 1.30479524 |
| 54 | MP0009333_abnormal_splenocyte_physiolog | 1.26212057 |
| 55 | MP0008260_abnormal_autophagy | 1.25321331 |
| 56 | MP0006082_CNS_inflammation | 1.24310736 |
| 57 | MP0003448_altered_tumor_morphology | 1.22269274 |
| 58 | MP0004947_skin_inflammation | 1.20630534 |
| 59 | MP0000569_abnormal_digit_pigmentation | 1.19666330 |
| 60 | MP0008057_abnormal_DNA_replication | 1.19663266 |
| 61 | MP0003763_abnormal_thymus_physiology | 1.18932335 |
| 62 | MP0002006_tumorigenesis | 1.17424757 |
| 63 | MP0005310_abnormal_salivary_gland | 1.16821407 |
| 64 | MP0003787_abnormal_imprinting | 1.16592112 |
| 65 | MP0003656_abnormal_erythrocyte_physiolo | 1.13764350 |
| 66 | MP0005076_abnormal_cell_differentiation | 1.13125951 |
| 67 | MP0003077_abnormal_cell_cycle | 1.11301746 |
| 68 | MP0000703_abnormal_thymus_morphology | 1.10671782 |
| 69 | MP0004381_abnormal_hair_follicle | 1.09618043 |
| 70 | MP0003828_pulmonary_edema | 1.07463253 |
| 71 | MP0004510_myositis | 1.07272689 |
| 72 | MP0001873_stomach_inflammation | 1.05359556 |
| 73 | MP0000015_abnormal_ear_pigmentation | 1.00028697 |
| 74 | MP0002132_abnormal_respiratory_system | 0.98531802 |
| 75 | MP0003191_abnormal_cellular_cholesterol | 0.97914974 |
| 76 | MP0002009_preneoplasia | 0.97553993 |
| 77 | MP0002933_joint_inflammation | 0.97512955 |
| 78 | MP0003806_abnormal_nucleotide_metabolis | 0.96906881 |
| 79 | MP0002019_abnormal_tumor_incidence | 0.96549969 |
| 80 | MP0003566_abnormal_cell_adhesion | 0.95412176 |
| 81 | MP0003866_abnormal_defecation | 0.92903048 |
| 82 | MP0008004_abnormal_stomach_pH | 0.92729649 |
| 83 | MP0004883_abnormal_blood_vessel | 0.90619691 |
| 84 | MP0002138_abnormal_hepatobiliary_system | 0.88336502 |
| 85 | MP0005390_skeleton_phenotype | 0.87959190 |
| 86 | MP0005166_decreased_susceptibility_to | 0.87913861 |
| 87 | MP0001663_abnormal_digestive_system | 0.87847328 |
| 88 | MP0003690_abnormal_glial_cell | 0.83964055 |
| 89 | MP0004957_abnormal_blastocyst_morpholog | 0.83313754 |
| 90 | MP0009763_increased_sensitivity_to | 0.81024241 |
| 91 | MP0006054_spinal_hemorrhage | 0.77131339 |
| 92 | MP0005023_abnormal_wound_healing | 0.77103087 |
| 93 | MP0009840_abnormal_foam_cell | 0.76048724 |
| 94 | MP0009765_abnormal_xenobiotic_induced | 0.73282746 |
| 95 | MP0002095_abnormal_skin_pigmentation | 0.72127882 |
| 96 | MP0005164_abnormal_response_to | 0.71735713 |
| 97 | MP0002277_abnormal_respiratory_mucosa | 0.70238086 |
| 98 | MP0000313_abnormal_cell_death | 0.67840419 |
| 99 | MP0010352_gastrointestinal_tract_polyps | 0.66157027 |
| 100 | MP0000249_abnormal_blood_vessel | 0.63550061 |
| 101 | MP0003795_abnormal_bone_structure | 0.63328033 |
| 102 | MP0003252_abnormal_bile_duct | 0.62282272 |
| 103 | MP0001986_abnormal_taste_sensitivity | 0.62170714 |
| 104 | MP0001764_abnormal_homeostasis | 0.61753858 |
| 105 | MP0002928_abnormal_bile_duct | 0.60889830 |
| 106 | MP0004484_altered_response_of | 0.59506814 |
| 107 | MP0005084_abnormal_gallbladder_morpholo | 0.59248068 |
| 108 | MP0000604_amyloidosis | 0.58412819 |
| 109 | MP0002998_abnormal_bone_remodeling | 0.58252504 |
| 110 | MP0005621_abnormal_cell_physiology | 0.56815286 |
| 111 | MP0005376_homeostasis/metabolism_phenot | 0.56617093 |
| 112 | MP0008874_decreased_physiological_sensi | 0.55809196 |
| 113 | MP0008058_abnormal_DNA_repair | 0.55751112 |
| 114 | MP0005451_abnormal_body_composition | 0.55346283 |
| 115 | MP0005319_abnormal_enzyme/_coenzyme | 0.52517903 |
| 116 | MP0003221_abnormal_cardiomyocyte_apopto | 0.50892597 |
| 117 | MP0008873_increased_physiological_sensi | 0.50705182 |
| 118 | MP0003045_fibrosis | 0.50632968 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 8.70149401 |
| 2 | Eczematoid dermatitis (HP:0000976) | 8.47003499 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 8.05017108 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 6.65645038 |
| 5 | Chronic obstructive pulmonary disease (HP:0006510) | 5.64552762 |
| 6 | Obstructive lung disease (HP:0006536) | 5.64552762 |
| 7 | Mediastinal lymphadenopathy (HP:0100721) | 5.03252369 |
| 8 | Recurrent skin infections (HP:0001581) | 4.92490212 |
| 9 | Abnormality of macrophages (HP:0004311) | 4.83880951 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.44918896 |
| 11 | Cellulitis (HP:0100658) | 4.25238000 |
| 12 | Gingivitis (HP:0000230) | 4.23252035 |
| 13 | Myositis (HP:0100614) | 4.14588695 |
| 14 | Meningitis (HP:0001287) | 4.10728286 |
| 15 | Gastrointestinal infarctions (HP:0005244) | 3.78762642 |
| 16 | T lymphocytopenia (HP:0005403) | 3.66731750 |
| 17 | Papilledema (HP:0001085) | 3.53436666 |
| 18 | Stomatitis (HP:0010280) | 3.44791603 |
| 19 | Abnormality of T cell number (HP:0011839) | 3.43375001 |
| 20 | Spontaneous hematomas (HP:0007420) | 3.41659447 |
| 21 | IgM deficiency (HP:0002850) | 3.38071499 |
| 22 | Urticaria (HP:0001025) | 3.34300207 |
| 23 | Thrombocytosis (HP:0001894) | 3.33687135 |
| 24 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.29721417 |
| 25 | Recurrent viral infections (HP:0004429) | 3.28353925 |
| 26 | Recurrent cutaneous fungal infections (HP:0011370) | 3.19084181 |
| 27 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.19084181 |
| 28 | Hypochromic microcytic anemia (HP:0004840) | 3.02273201 |
| 29 | Osteomyelitis (HP:0002754) | 2.99933757 |
| 30 | Chronic otitis media (HP:0000389) | 2.97035713 |
| 31 | Severe combined immunodeficiency (HP:0004430) | 2.93863765 |
| 32 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.86870600 |
| 33 | Vacuolated lymphocytes (HP:0001922) | 2.82815824 |
| 34 | Orchitis (HP:0100796) | 2.80816457 |
| 35 | Vasculitis (HP:0002633) | 2.79665251 |
| 36 | Agnosia (HP:0010524) | 2.78987162 |
| 37 | Recurrent pneumonia (HP:0006532) | 2.75094393 |
| 38 | Disinhibition (HP:0000734) | 2.70389700 |
| 39 | Periodontitis (HP:0000704) | 2.66799857 |
| 40 | Petechiae (HP:0000967) | 2.64335639 |
| 41 | Inflammation of the large intestine (HP:0002037) | 2.62813240 |
| 42 | Abnormality of the prostate (HP:0008775) | 2.60349677 |
| 43 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.58122049 |
| 44 | Gastrointestinal inflammation (HP:0004386) | 2.54813260 |
| 45 | Autoimmune hemolytic anemia (HP:0001890) | 2.54188171 |
| 46 | Episodic fever (HP:0001954) | 2.53166296 |
| 47 | Hypochromic anemia (HP:0001931) | 2.51764095 |
| 48 | Sepsis (HP:0100806) | 2.50049122 |
| 49 | Abnormal platelet volume (HP:0011876) | 2.49673961 |
| 50 | Abnormality of eosinophils (HP:0001879) | 2.49381866 |
| 51 | Interstitial pulmonary disease (HP:0006530) | 2.48633593 |
| 52 | Hematochezia (HP:0002573) | 2.44481163 |
| 53 | Amyloidosis (HP:0011034) | 2.43787260 |
| 54 | Retrobulbar optic neuritis (HP:0100654) | 2.41187242 |
| 55 | Optic neuritis (HP:0100653) | 2.41187242 |
| 56 | Spinal cord lesions (HP:0100561) | 2.40130198 |
| 57 | Syringomyelia (HP:0003396) | 2.40130198 |
| 58 | Pustule (HP:0200039) | 2.39952924 |
| 59 | Epistaxis (HP:0000421) | 2.38215275 |
| 60 | Anorexia (HP:0002039) | 2.38192605 |
| 61 | Abnormality of T cell physiology (HP:0011840) | 2.37520937 |
| 62 | Recurrent lower respiratory tract infections (HP:0002783) | 2.37282823 |
| 63 | Chest pain (HP:0100749) | 2.36578000 |
| 64 | Encephalitis (HP:0002383) | 2.35669837 |
| 65 | Hypoplasia of the thymus (HP:0000778) | 2.34908223 |
| 66 | Peritonitis (HP:0002586) | 2.32613631 |
| 67 | Combined immunodeficiency (HP:0005387) | 2.32597486 |
| 68 | Leukocytosis (HP:0001974) | 2.32570029 |
| 69 | Skin rash (HP:0000988) | 2.32010550 |
| 70 | Gangrene (HP:0100758) | 2.30880152 |
| 71 | Increased IgM level (HP:0003496) | 2.29730603 |
| 72 | Hemoptysis (HP:0002105) | 2.29414740 |
| 73 | Microcytic anemia (HP:0001935) | 2.28774971 |
| 74 | Recurrent bronchitis (HP:0002837) | 2.28194646 |
| 75 | Chromsome breakage (HP:0040012) | 2.27519218 |
| 76 | Colitis (HP:0002583) | 2.27023631 |
| 77 | Thyroiditis (HP:0100646) | 2.25183353 |
| 78 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.23156903 |
| 79 | Hypergammaglobulinemia (HP:0010702) | 2.23041631 |
| 80 | Prolonged bleeding time (HP:0003010) | 2.22964962 |
| 81 | Keratoconjunctivitis sicca (HP:0001097) | 2.22622231 |
| 82 | Skin ulcer (HP:0200042) | 2.20561260 |
| 83 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.17063378 |
| 84 | Chronic sinusitis (HP:0011109) | 2.15954967 |
| 85 | Increased cerebral lipofuscin (HP:0011813) | 2.15938116 |
| 86 | Viral hepatitis (HP:0006562) | 2.15269468 |
| 87 | Eosinophilia (HP:0001880) | 2.14681947 |
| 88 | Long clavicles (HP:0000890) | 2.13696522 |
| 89 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.12567144 |
| 90 | Lymphopenia (HP:0001888) | 2.11664338 |
| 91 | IgG deficiency (HP:0004315) | 2.11575302 |
| 92 | Thoracic kyphosis (HP:0002942) | 2.11301893 |
| 93 | Abnormality of the thoracic spine (HP:0100711) | 2.08471986 |
| 94 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.08339859 |
| 95 | Recurrent sinusitis (HP:0011108) | 2.08210571 |
| 96 | Abnormality of the peritoneum (HP:0002585) | 2.07167802 |
| 97 | Pulmonary infiltrates (HP:0002113) | 2.06814932 |
| 98 | Vertigo (HP:0002321) | 2.06303663 |
| 99 | Dysostosis multiplex (HP:0000943) | 2.06066168 |
| 100 | Cutaneous melanoma (HP:0012056) | 2.05418879 |
| 101 | Arterial thrombosis (HP:0004420) | 2.05094685 |
| 102 | Cheilitis (HP:0100825) | 2.03616571 |
| 103 | Granulocytopenia (HP:0001913) | 2.03021623 |
| 104 | Gingival bleeding (HP:0000225) | 2.01892149 |
| 105 | Amaurosis fugax (HP:0100576) | 2.00847881 |
| 106 | Keratoconjunctivitis (HP:0001096) | 1.99303441 |
| 107 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.99267056 |
| 108 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.99267056 |
| 109 | Abnormality of glycolipid metabolism (HP:0010969) | 1.99267056 |
| 110 | Agammaglobulinemia (HP:0004432) | 1.96718280 |
| 111 | Absent frontal sinuses (HP:0002688) | 1.95283949 |
| 112 | Thickened calvaria (HP:0002684) | 1.94448991 |
| 113 | Increased mean platelet volume (HP:0011877) | 1.92913371 |
| 114 | Joint hemorrhage (HP:0005261) | 1.92480536 |
| 115 | Mucopolysacchariduria (HP:0008155) | 1.91707524 |
| 116 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.91707524 |
| 117 | Spondylolisthesis (HP:0003302) | 1.91249933 |
| 118 | Panhypogammaglobulinemia (HP:0003139) | 1.91222264 |
| 119 | Hepatosplenomegaly (HP:0001433) | 1.90135211 |
| 120 | Autoimmune thrombocytopenia (HP:0001973) | 1.90125691 |
| 121 | Increased IgE level (HP:0003212) | 1.86775040 |
| 122 | J-shaped sella turcica (HP:0002680) | 1.86398593 |
| 123 | Abnormality of lateral ventricle (HP:0030047) | 1.86259344 |
| 124 | Acute lymphatic leukemia (HP:0006721) | 1.85379953 |
| 125 | Abnormality of the pleura (HP:0002103) | 1.84817965 |
| 126 | B lymphocytopenia (HP:0010976) | 1.84687186 |
| 127 | Abnormality of B cell number (HP:0010975) | 1.84687186 |
| 128 | Verrucae (HP:0200043) | 1.83628761 |
| 129 | Papilloma (HP:0012740) | 1.83628761 |
| 130 | Abnormality of T cells (HP:0002843) | 1.83594699 |
| 131 | Pulmonary embolism (HP:0002204) | 1.83092789 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRAK4 | 4.95917820 |
| 2 | MAP4K1 | 3.52060420 |
| 3 | RIPK4 | 3.28624076 |
| 4 | BLK | 3.23222562 |
| 5 | TEC | 2.83279381 |
| 6 | BTK | 2.77898728 |
| 7 | STK10 | 2.65281077 |
| 8 | CLK1 | 2.50065378 |
| 9 | FES | 2.36887849 |
| 10 | GRK6 | 2.26901154 |
| 11 | EPHB1 | 2.10252756 |
| 12 | TRPM7 | 2.07443815 |
| 13 | CSK | 2.04113865 |
| 14 | BMPR2 | 1.96842704 |
| 15 | CDK19 | 1.93419587 |
| 16 | IRAK3 | 1.91372219 |
| 17 | ERN1 | 1.89819658 |
| 18 | TYK2 | 1.87769488 |
| 19 | TAOK3 | 1.83309443 |
| 20 | TESK2 | 1.82194193 |
| 21 | BCKDK | 1.80337749 |
| 22 | MAP2K3 | 1.79468323 |
| 23 | KIT | 1.76743211 |
| 24 | MAP3K14 | 1.72823310 |
| 25 | SYK | 1.64241375 |
| 26 | CSF1R | 1.61229719 |
| 27 | TRIB3 | 1.53990270 |
| 28 | MAP3K12 | 1.53916326 |
| 29 | LRRK2 | 1.43898400 |
| 30 | FGR | 1.41281701 |
| 31 | HCK | 1.37494152 |
| 32 | ITK | 1.37387219 |
| 33 | MAP3K13 | 1.33628155 |
| 34 | TBK1 | 1.25819919 |
| 35 | PIM1 | 1.25686889 |
| 36 | NEK2 | 1.25656621 |
| 37 | LYN | 1.21826869 |
| 38 | ZAP70 | 1.21014584 |
| 39 | PKN2 | 1.17994184 |
| 40 | IRAK1 | 1.16180531 |
| 41 | PRPF4B | 1.15874267 |
| 42 | EIF2AK3 | 1.10558710 |
| 43 | PAK4 | 1.09224243 |
| 44 | IRAK2 | 1.06255338 |
| 45 | TESK1 | 1.05149814 |
| 46 | RPS6KA4 | 1.02714703 |
| 47 | MAP3K8 | 1.02176923 |
| 48 | CDC7 | 1.02060428 |
| 49 | MAP3K1 | 0.97294209 |
| 50 | CDK12 | 0.91142415 |
| 51 | MAPK4 | 0.89733209 |
| 52 | RPS6KA6 | 0.89204684 |
| 53 | PIM2 | 0.88345963 |
| 54 | RPS6KC1 | 0.87758164 |
| 55 | RPS6KL1 | 0.87758164 |
| 56 | LCK | 0.87387858 |
| 57 | STK4 | 0.86753037 |
| 58 | JAK1 | 0.85696140 |
| 59 | EEF2K | 0.84246608 |
| 60 | ALK | 0.83026542 |
| 61 | BRSK2 | 0.82506795 |
| 62 | JAK3 | 0.82230780 |
| 63 | IKBKB | 0.81410567 |
| 64 | TXK | 0.75840017 |
| 65 | WEE1 | 0.74918948 |
| 66 | BUB1 | 0.73612224 |
| 67 | IKBKE | 0.73579860 |
| 68 | TTN | 0.69103336 |
| 69 | CDK4 | 0.68526321 |
| 70 | MAPKAPK2 | 0.66549507 |
| 71 | RPS6KA2 | 0.65635341 |
| 72 | ATR | 0.65218735 |
| 73 | JAK2 | 0.64161515 |
| 74 | MAP2K4 | 0.61625824 |
| 75 | MAP3K11 | 0.60948724 |
| 76 | EIF2AK1 | 0.60838035 |
| 77 | MARK3 | 0.59763340 |
| 78 | SIK3 | 0.59245982 |
| 79 | CDK7 | 0.57548433 |
| 80 | DAPK2 | 0.56288322 |
| 81 | PRKCD | 0.55792409 |
| 82 | EIF2AK2 | 0.55665660 |
| 83 | MATK | 0.55471675 |
| 84 | CDK6 | 0.55426209 |
| 85 | FLT3 | 0.55175096 |
| 86 | MAPK12 | 0.55134445 |
| 87 | YES1 | 0.54723577 |
| 88 | PTK6 | 0.53479960 |
| 89 | MAP3K2 | 0.51742175 |
| 90 | HIPK2 | 0.51409033 |
| 91 | STK11 | 0.51327033 |
| 92 | PIK3CG | 0.51045478 |
| 93 | TNK2 | 0.50857296 |
| 94 | FGFR3 | 0.50393804 |
| 95 | PDPK1 | 0.49895161 |
| 96 | TAOK1 | 0.49595469 |
| 97 | ERBB3 | 0.48957928 |
| 98 | ABL1 | 0.48836321 |
| 99 | KSR2 | 0.48478712 |
| 100 | NLK | 0.48341662 |
| 101 | CCNB1 | 0.46317742 |
| 102 | ACVR1B | 0.46231701 |
| 103 | MAP2K6 | 0.45216430 |
| 104 | PRKCQ | 0.45096709 |
| 105 | PRKG2 | 0.44242450 |
| 106 | TAOK2 | 0.43903709 |
| 107 | STK24 | 0.43777009 |
| 108 | MAP3K10 | 0.41951368 |
| 109 | GRK7 | 0.41717134 |
| 110 | PRKD2 | 0.41606104 |
| 111 | MARK2 | 0.41003448 |
| 112 | SIK2 | 0.40214568 |
| 113 | PDK1 | 0.39228372 |
| 114 | SGK3 | 0.36898128 |
| 115 | TGFBR2 | 0.36781936 |
| 116 | MAPK7 | 0.36617434 |
| 117 | CAMKK2 | 0.36541222 |
| 118 | MAP3K3 | 0.36521973 |
| 119 | FRK | 0.35927507 |
| 120 | MAPK11 | 0.35613199 |
| 121 | KDR | 0.34144707 |
| 122 | DYRK3 | 0.33880521 |
| 123 | DYRK1B | 0.33446453 |
| 124 | MAP3K5 | 0.32717567 |
| 125 | DMPK | 0.32040798 |
| 126 | MAP3K7 | 0.31469714 |
| 127 | MAP3K6 | 0.30686452 |
| 128 | FYN | 0.29447120 |
| 129 | RET | 0.28531618 |
| 130 | PTK2B | 0.27253389 |
| 131 | CHUK | 0.26617628 |
| 132 | OXSR1 | 0.26423583 |
| 133 | PLK1 | 0.26209778 |
| 134 | RAF1 | 0.25424816 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 3.82854608 |
| 2 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.93760459 |
| 3 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.54894350 |
| 4 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.51036299 |
| 5 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.50607600 |
| 6 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.41213651 |
| 7 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.35939157 |
| 8 | DNA replication_Homo sapiens_hsa03030 | 2.27812012 |
| 9 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 2.25668542 |
| 10 | Asthma_Homo sapiens_hsa05310 | 2.18664452 |
| 11 | Tuberculosis_Homo sapiens_hsa05152 | 2.11227560 |
| 12 | Other glycan degradation_Homo sapiens_hsa00511 | 2.06352874 |
| 13 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 2.02525121 |
| 14 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.02515302 |
| 15 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.93860673 |
| 16 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.79218557 |
| 17 | Legionellosis_Homo sapiens_hsa05134 | 1.77812457 |
| 18 | Pertussis_Homo sapiens_hsa05133 | 1.77370209 |
| 19 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.76139522 |
| 20 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.75774326 |
| 21 | Shigellosis_Homo sapiens_hsa05131 | 1.74241898 |
| 22 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.67828030 |
| 23 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.67289521 |
| 24 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.63571705 |
| 25 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.61976395 |
| 26 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.60933856 |
| 27 | Measles_Homo sapiens_hsa05162 | 1.59612417 |
| 28 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.59219569 |
| 29 | Phagosome_Homo sapiens_hsa04145 | 1.54821282 |
| 30 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.53432112 |
| 31 | Mismatch repair_Homo sapiens_hsa03430 | 1.44705776 |
| 32 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.44574085 |
| 33 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.41024389 |
| 34 | Salmonella infection_Homo sapiens_hsa05132 | 1.38749723 |
| 35 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.38182910 |
| 36 | Lysosome_Homo sapiens_hsa04142 | 1.37893061 |
| 37 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.33498453 |
| 38 | Apoptosis_Homo sapiens_hsa04210 | 1.33051865 |
| 39 | Homologous recombination_Homo sapiens_hsa03440 | 1.31011075 |
| 40 | Base excision repair_Homo sapiens_hsa03410 | 1.29423000 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.29137330 |
| 42 | Platelet activation_Homo sapiens_hsa04611 | 1.25504072 |
| 43 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.22679969 |
| 44 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.22291038 |
| 45 | Influenza A_Homo sapiens_hsa05164 | 1.20080741 |
| 46 | Viral myocarditis_Homo sapiens_hsa05416 | 1.17559843 |
| 47 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.16916724 |
| 48 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.15533263 |
| 49 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.15148648 |
| 50 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.14170867 |
| 51 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.14148094 |
| 52 | Cell cycle_Homo sapiens_hsa04110 | 1.13323188 |
| 53 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.04295240 |
| 54 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.03167004 |
| 55 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.02523045 |
| 56 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.01567940 |
| 57 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.97419877 |
| 58 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.96443761 |
| 59 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.96403825 |
| 60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.93668038 |
| 61 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.91566906 |
| 62 | Malaria_Homo sapiens_hsa05144 | 0.88888508 |
| 63 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.85663678 |
| 64 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.83778476 |
| 65 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.82643644 |
| 66 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.79669839 |
| 67 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.78363576 |
| 68 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.74395107 |
| 69 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.70646187 |
| 70 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.68956436 |
| 71 | Hepatitis C_Homo sapiens_hsa05160 | 0.67610840 |
| 72 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.65987715 |
| 73 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.63830286 |
| 74 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.62314519 |
| 75 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.62178516 |
| 76 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.60220341 |
| 77 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.58852547 |
| 78 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.58031918 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.52467017 |
| 80 | Spliceosome_Homo sapiens_hsa03040 | 0.51821775 |
| 81 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.51750609 |
| 82 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.49461117 |
| 83 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.49046930 |
| 84 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.48768395 |
| 85 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.46885781 |
| 86 | Allograft rejection_Homo sapiens_hsa05330 | 0.46852254 |
| 87 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.45765713 |
| 88 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.45689998 |
| 89 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.44884707 |
| 90 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.44604975 |
| 91 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43841219 |
| 92 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.42908972 |
| 93 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.42411161 |
| 94 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41243721 |
| 95 | HTLV-I infection_Homo sapiens_hsa05166 | 0.40407516 |
| 96 | Colorectal cancer_Homo sapiens_hsa05210 | 0.40039785 |
| 97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.38274624 |
| 98 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.37526402 |
| 99 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.37473862 |
| 100 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.36479158 |
| 101 | Amoebiasis_Homo sapiens_hsa05146 | 0.34792789 |
| 102 | Insulin resistance_Homo sapiens_hsa04931 | 0.34602466 |
| 103 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.34277988 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.33653883 |
| 105 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.32606114 |
| 106 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.32438073 |
| 107 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.32422436 |
| 108 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.31480733 |
| 109 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.31347177 |
| 110 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.30785187 |
| 111 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.30388907 |
| 112 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.29713419 |
| 113 | RNA transport_Homo sapiens_hsa03013 | 0.29673116 |
| 114 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.29096292 |
| 115 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.28858705 |
| 116 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.28290872 |
| 117 | Endocytosis_Homo sapiens_hsa04144 | 0.26749892 |
| 118 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.26009298 |
| 119 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.25976091 |
| 120 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.25303323 |
| 121 | Prostate cancer_Homo sapiens_hsa05215 | 0.25120918 |
| 122 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.22592808 |
| 123 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.21281270 |
| 124 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.20688015 |
| 125 | Olfactory transduction_Homo sapiens_hsa04740 | 0.20355466 |
| 126 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.19453960 |

