GAPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)7.35464098
2neutrophil activation involved in immune response (GO:0002283)6.44975458
3respiratory burst (GO:0045730)6.13143304
4cellular extravasation (GO:0045123)6.08187388
5neutrophil mediated immunity (GO:0002446)5.99692947
6response to peptidoglycan (GO:0032494)5.87034861
7leukocyte migration involved in inflammatory response (GO:0002523)5.78148315
8defense response to fungus (GO:0050832)5.68689111
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62515763
10response to fungus (GO:0009620)5.59455409
11killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.53460792
12disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.53460792
13neutrophil activation (GO:0042119)5.31790090
14regulation of B cell receptor signaling pathway (GO:0050855)5.27904159
15negative regulation of phagocytosis (GO:0050765)5.25007652
16production of molecular mediator involved in inflammatory response (GO:0002532)5.18146743
17granulocyte activation (GO:0036230)4.88606577
18Arp2/3 complex-mediated actin nucleation (GO:0034314)4.72580328
19superoxide anion generation (GO:0042554)4.58527073
20myeloid leukocyte mediated immunity (GO:0002444)4.46406437
21sequestering of metal ion (GO:0051238)4.39847606
22regulation of mast cell activation (GO:0033003)4.39751367
23positive regulation of mast cell activation (GO:0033005)4.38829926
24detection of external biotic stimulus (GO:0098581)4.35503834
25microglial cell activation (GO:0001774)4.27255792
26regulation of mast cell degranulation (GO:0043304)4.26605739
27regulation of gamma-delta T cell activation (GO:0046643)4.26565121
28detection of molecule of bacterial origin (GO:0032490)4.24801935
29reactive oxygen species biosynthetic process (GO:1903409)4.18372515
30macrophage differentiation (GO:0030225)4.15117330
31regulation of myeloid leukocyte mediated immunity (GO:0002886)4.12751365
32disruption of cells of other organism (GO:0044364)4.05597584
33killing of cells of other organism (GO:0031640)4.05597584
34pentose-phosphate shunt (GO:0006098)4.02348180
35leukocyte mediated cytotoxicity (GO:0001909)4.01428097
36regulation of leukocyte degranulation (GO:0043300)4.00663758
37leukotriene metabolic process (GO:0006691)3.96895136
38regulation of mast cell activation involved in immune response (GO:0033006)3.92647146
39hydrogen peroxide biosynthetic process (GO:0050665)3.91168199
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.90777350
41positive regulation of mast cell degranulation (GO:0043306)3.90777350
42detection of biotic stimulus (GO:0009595)3.88597448
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.88080155
44regulation of gamma-delta T cell differentiation (GO:0045586)3.86971548
45immunoglobulin mediated immune response (GO:0016064)3.85912533
46regulation of B cell differentiation (GO:0045577)3.81094252
47leukotriene biosynthetic process (GO:0019370)3.75812674
48detection of other organism (GO:0098543)3.74788039
49negative regulation of cell killing (GO:0031342)3.74486132
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74486132
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72571941
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72571941
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.72571941
54modulation by symbiont of host immune response (GO:0052553)3.72571941
55positive regulation by symbiont of host defense response (GO:0052509)3.72571941
56modulation by symbiont of host defense response (GO:0052031)3.72571941
57positive thymic T cell selection (GO:0045059)3.71601034
58neutrophil chemotaxis (GO:0030593)3.69102603
59B cell receptor signaling pathway (GO:0050853)3.66437105
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.65397155
61NADPH regeneration (GO:0006740)3.63233329
62cellular response to zinc ion (GO:0071294)3.61221986
63leukocyte degranulation (GO:0043299)3.59769293
64detection of bacterium (GO:0016045)3.59108132
65neutrophil migration (GO:1990266)3.58733985
66macrophage activation (GO:0042116)3.58021303
67negative regulation of mast cell activation (GO:0033004)3.56273786
68myeloid cell activation involved in immune response (GO:0002275)3.53644822
69actin nucleation (GO:0045010)3.49298615
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47865434
71regulation of growth of symbiont in host (GO:0044126)3.45301559
72negative regulation of growth of symbiont in host (GO:0044130)3.45301559
73negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.45301559
74modulation of growth of symbiont involved in interaction with host (GO:0044144)3.45301559
75positive regulation of B cell differentiation (GO:0045579)3.44426181
76defense response to protozoan (GO:0042832)3.44021069
77lipoxygenase pathway (GO:0019372)3.42759791
78regulation of regulated secretory pathway (GO:1903305)3.41523276
79negative regulation of T cell mediated immunity (GO:0002710)3.40957313
80positive regulation of lamellipodium assembly (GO:0010592)3.40916652
81regulation of alpha-beta T cell proliferation (GO:0046640)3.40700178
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.39792866
83regulation of antigen processing and presentation (GO:0002577)3.34526066
84interferon-gamma-mediated signaling pathway (GO:0060333)3.33827287
85regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33085825
86response to interleukin-15 (GO:0070672)3.32480430
87leukocyte cell-cell adhesion (GO:0007159)3.31844751
88response to host immune response (GO:0052572)3.31654080
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31654080
90negative regulation of leukocyte mediated immunity (GO:0002704)3.28598709
91mast cell activation (GO:0045576)3.28124744
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27873675
93negative thymic T cell selection (GO:0045060)3.27169315
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26256131
95response to muramyl dipeptide (GO:0032495)3.26138153
96positive regulation of granulocyte differentiation (GO:0030854)3.24925592
97antigen processing and presentation via MHC class Ib (GO:0002475)3.24422282
98granulocyte migration (GO:0097530)3.19051720
99negative regulation of T-helper cell differentiation (GO:0045623)3.18273783
100negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18273783
101positive regulation of gamma-delta T cell activation (GO:0046645)3.17965030
102antigen processing and presentation of endogenous antigen (GO:0019883)3.14425916
103positive regulation of antigen processing and presentation (GO:0002579)3.14008643
104negative regulation of erythrocyte differentiation (GO:0045647)3.13497803
105negative T cell selection (GO:0043383)3.13070784
106macrophage activation involved in immune response (GO:0002281)3.11778484
107response to protozoan (GO:0001562)3.10873028
108positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.10442123
109granulocyte chemotaxis (GO:0071621)3.09465005
110cell killing (GO:0001906)3.08006395
111positive T cell selection (GO:0043368)3.06561906
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05622524
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05622524
114positive regulation of interferon-alpha production (GO:0032727)3.05467720
115negative regulation of alpha-beta T cell activation (GO:0046636)3.03806493
116B cell mediated immunity (GO:0019724)3.03409828
117regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02617082
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01167989
119response to host (GO:0075136)3.01167989
120response to host defenses (GO:0052200)3.01167989
121cellular response to type I interferon (GO:0071357)3.00504766
122type I interferon signaling pathway (GO:0060337)3.00504766
123response to type I interferon (GO:0034340)2.99331656
124regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98795335
125regulation of tolerance induction (GO:0002643)2.98388728
126dendritic cell migration (GO:0036336)2.98204677
127cellular response to interleukin-15 (GO:0071350)2.97780361
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97552220
129positive regulation of leukocyte degranulation (GO:0043302)2.93785379
130positive regulation of lamellipodium organization (GO:1902745)2.91451707
131negative regulation of interleukin-12 production (GO:0032695)2.88845966
132regulation of T-helper 2 cell differentiation (GO:0045628)2.88569097
133negative regulation of B cell proliferation (GO:0030889)2.88026673
134T cell migration (GO:0072678)2.87604990
135regulation of interferon-alpha production (GO:0032647)2.87027339
136dendritic cell chemotaxis (GO:0002407)2.86371975
137phagosome maturation (GO:0090382)2.85949723
138regulation of interferon-beta biosynthetic process (GO:0045357)2.79621537
139mast cell degranulation (GO:0043303)2.78966290
140mast cell activation involved in immune response (GO:0002279)2.78966290
141pentose metabolic process (GO:0019321)2.78044770
142regulation of B cell apoptotic process (GO:0002902)2.77743168
143angiogenesis involved in wound healing (GO:0060055)2.77289293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.58929852
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.89493681
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.67475636
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.07785123
5* MYB_21317192_ChIP-Seq_ERMYB_Mouse4.02134646
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.80193206
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.54880941
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.54529976
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22382176
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.16860246
11VDR_21846776_ChIP-Seq_THP-1_Human3.06723124
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96122597
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93654910
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.91670008
15* SPI1_23547873_ChIP-Seq_NB4_Human2.85537969
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.84407261
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71710093
18SCL_19346495_ChIP-Seq_HPC-7_Human2.64511132
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62022827
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56082788
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51862973
22VDR_24763502_ChIP-Seq_THP-1_Human2.31780664
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28529186
24MYC_22102868_ChIP-Seq_BL_Human2.21972418
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.20566986
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14804576
27MYB_26560356_Chip-Seq_TH2_Human2.09936500
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07251680
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03190264
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02175037
31MAF_26560356_Chip-Seq_TH1_Human1.97418585
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96296717
33SPI1_23127762_ChIP-Seq_K562_Human1.91584014
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86920273
35MYB_26560356_Chip-Seq_TH1_Human1.85967872
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84073827
37UTX_26944678_Chip-Seq_JUKART_Human1.83504357
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81658576
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77753313
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77143418
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76119325
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74644083
43GATA1_22025678_ChIP-Seq_K562_Human1.65169085
44PU_27001747_Chip-Seq_BMDM_Mouse1.60788196
45TCF7_22412390_ChIP-Seq_EML_Mouse1.60530216
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57410942
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54962971
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51359434
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50989759
50RUNX_20019798_ChIP-Seq_JUKART_Human1.44856756
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44701860
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41598832
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41234617
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.39983266
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39576799
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38477871
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37056536
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35756249
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35123129
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34226588
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31555376
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.30584236
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29572984
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29422832
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24340074
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22376382
67GATA3_27048872_Chip-Seq_THYMUS_Human1.22289979
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21868687
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20124555
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18493468
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14073889
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12075742
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11246523
74GATA3_26560356_Chip-Seq_TH2_Human1.08969309
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08075215
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07805058
77MAF_26560356_Chip-Seq_TH2_Human1.07399768
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.07116491
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06609367
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06289131
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.06175387
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05698400
83CIITA_25753668_ChIP-Seq_RAJI_Human1.04460825
84GATA1_19941826_ChIP-Seq_K562_Human1.03524245
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03278401
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99445595
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99080681
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97737712
89KDM2B_26808549_Chip-Seq_DND41_Human0.94195933
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92939567
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92672797
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91576932
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91291574
94TFEB_21752829_ChIP-Seq_HELA_Human0.88793515
95* BCL6_27268052_Chip-Seq_Bcells_Human0.87537825
96FOXP3_21729870_ChIP-Seq_TREG_Human0.85622579
97SMRT_27268052_Chip-Seq_Bcells_Human0.84378181
98VDR_24787735_ChIP-Seq_THP-1_Human0.83739791
99ELK1_19687146_ChIP-ChIP_HELA_Human0.83447215
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.82142057
101SPI1_20517297_ChIP-Seq_HL60_Human0.81648685
102VDR_23849224_ChIP-Seq_CD4+_Human0.81245031
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78129134
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77980187
105IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76711855
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76709648
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75406884
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75340019
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75054481
110GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74027685
111* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73139620
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73088652
113P300_27268052_Chip-Seq_Bcells_Human0.72918739
114RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72493219
115GATA3_26560356_Chip-Seq_TH1_Human0.72389325
116GATA2_19941826_ChIP-Seq_K562_Human0.70661996
117RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70202912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.93081341
2MP0003436_decreased_susceptibility_to4.38438731
3MP0001835_abnormal_antigen_presentation3.82105570
4MP0002419_abnormal_innate_immunity3.40935473
5MP0009785_altered_susceptibility_to3.24875153
6MP0003183_abnormal_peptide_metabolism3.03113918
7MP0005025_abnormal_response_to2.89349299
8MP0005000_abnormal_immune_tolerance2.73129805
9MP0005464_abnormal_platelet_physiology2.64265058
10* MP0002452_abnormal_antigen_presenting2.56632332
11* MP0001800_abnormal_humoral_immune2.55067747
12MP0002148_abnormal_hypersensitivity_rea2.54580709
13* MP0002420_abnormal_adaptive_immunity2.44507113
14* MP0001819_abnormal_immune_cell2.43189293
15MP0000685_abnormal_immune_system2.41905751
16MP0009278_abnormal_bone_marrow2.39859213
17MP0005387_immune_system_phenotype2.39246932
18MP0001790_abnormal_immune_system2.39246932
19* MP0002723_abnormal_immune_serum2.31707526
20MP0002396_abnormal_hematopoietic_system2.24849465
21MP0001853_heart_inflammation2.14067416
22MP0002405_respiratory_system_inflammati2.13845104
23MP0000465_gastrointestinal_hemorrhage2.09922879
24MP0001533_abnormal_skeleton_physiology2.06282195
25MP0005671_abnormal_response_to2.06258129
26* MP0002398_abnormal_bone_marrow2.05360485
27MP0004808_abnormal_hematopoietic_stem2.03167535
28MP0001545_abnormal_hematopoietic_system2.02972762
29MP0005397_hematopoietic_system_phenotyp2.02972762
30MP0003724_increased_susceptibility_to1.95856308
31* MP0000716_abnormal_immune_system1.95198241
32MP0001845_abnormal_inflammatory_respons1.93334867
33MP0000343_altered_response_to1.81529357
34MP0003300_gastrointestinal_ulcer1.78472674
35MP0005058_abnormal_lysosome_morphology1.76231183
36MP0003172_abnormal_lysosome_physiology1.71330573
37MP0010155_abnormal_intestine_physiology1.69257742
38MP0010307_abnormal_tumor_latency1.68367744
39* MP0002429_abnormal_blood_cell1.68172208
40MP0002722_abnormal_immune_system1.65720811
41* MP0000689_abnormal_spleen_morphology1.64718985
42MP0003693_abnormal_embryo_hatching1.64155916
43MP0000858_altered_metastatic_potential1.59840233
44MP0001851_eye_inflammation1.55501071
45MP0002166_altered_tumor_susceptibility1.42817691
46MP0005174_abnormal_tail_pigmentation1.41968537
47MP0003075_altered_response_to1.41292700
48MP0005075_abnormal_melanosome_morpholog1.39648974
49MP0008469_abnormal_protein_level1.36024836
50MP0000490_abnormal_crypts_of1.35533996
51MP0009764_decreased_sensitivity_to1.34454187
52MP0010094_abnormal_chromosome_stability1.30741431
53MP0003111_abnormal_nucleus_morphology1.30479524
54MP0009333_abnormal_splenocyte_physiolog1.26212057
55MP0008260_abnormal_autophagy1.25321331
56MP0006082_CNS_inflammation1.24310736
57MP0003448_altered_tumor_morphology1.22269274
58MP0004947_skin_inflammation1.20630534
59MP0000569_abnormal_digit_pigmentation1.19666330
60MP0008057_abnormal_DNA_replication1.19663266
61MP0003763_abnormal_thymus_physiology1.18932335
62MP0002006_tumorigenesis1.17424757
63MP0005310_abnormal_salivary_gland1.16821407
64MP0003787_abnormal_imprinting1.16592112
65MP0003656_abnormal_erythrocyte_physiolo1.13764350
66MP0005076_abnormal_cell_differentiation1.13125951
67MP0003077_abnormal_cell_cycle1.11301746
68MP0000703_abnormal_thymus_morphology1.10671782
69MP0004381_abnormal_hair_follicle1.09618043
70MP0003828_pulmonary_edema1.07463253
71MP0004510_myositis1.07272689
72MP0001873_stomach_inflammation1.05359556
73MP0000015_abnormal_ear_pigmentation1.00028697
74MP0002132_abnormal_respiratory_system0.98531802
75MP0003191_abnormal_cellular_cholesterol0.97914974
76MP0002009_preneoplasia0.97553993
77MP0002933_joint_inflammation0.97512955
78MP0003806_abnormal_nucleotide_metabolis0.96906881
79MP0002019_abnormal_tumor_incidence0.96549969
80MP0003566_abnormal_cell_adhesion0.95412176
81MP0003866_abnormal_defecation0.92903048
82MP0008004_abnormal_stomach_pH0.92729649
83MP0004883_abnormal_blood_vessel0.90619691
84MP0002138_abnormal_hepatobiliary_system0.88336502
85MP0005390_skeleton_phenotype0.87959190
86MP0005166_decreased_susceptibility_to0.87913861
87MP0001663_abnormal_digestive_system0.87847328
88MP0003690_abnormal_glial_cell0.83964055
89MP0004957_abnormal_blastocyst_morpholog0.83313754
90MP0009763_increased_sensitivity_to0.81024241
91MP0006054_spinal_hemorrhage0.77131339
92MP0005023_abnormal_wound_healing0.77103087
93MP0009840_abnormal_foam_cell0.76048724
94MP0009765_abnormal_xenobiotic_induced0.73282746
95MP0002095_abnormal_skin_pigmentation0.72127882
96MP0005164_abnormal_response_to0.71735713
97MP0002277_abnormal_respiratory_mucosa0.70238086
98MP0000313_abnormal_cell_death0.67840419
99MP0010352_gastrointestinal_tract_polyps0.66157027
100MP0000249_abnormal_blood_vessel0.63550061
101MP0003795_abnormal_bone_structure0.63328033
102MP0003252_abnormal_bile_duct0.62282272
103MP0001986_abnormal_taste_sensitivity0.62170714
104MP0001764_abnormal_homeostasis0.61753858
105MP0002928_abnormal_bile_duct0.60889830
106MP0004484_altered_response_of0.59506814
107MP0005084_abnormal_gallbladder_morpholo0.59248068
108MP0000604_amyloidosis0.58412819
109MP0002998_abnormal_bone_remodeling0.58252504
110MP0005621_abnormal_cell_physiology0.56815286
111MP0005376_homeostasis/metabolism_phenot0.56617093
112MP0008874_decreased_physiological_sensi0.55809196
113MP0008058_abnormal_DNA_repair0.55751112
114MP0005451_abnormal_body_composition0.55346283
115MP0005319_abnormal_enzyme/_coenzyme0.52517903
116MP0003221_abnormal_cardiomyocyte_apopto0.50892597
117MP0008873_increased_physiological_sensi0.50705182
118MP0003045_fibrosis0.50632968

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.70149401
2Eczematoid dermatitis (HP:0000976)8.47003499
3Recurrent bacterial skin infections (HP:0005406)8.05017108
4Recurrent gram-negative bacterial infections (HP:0005420)6.65645038
5Chronic obstructive pulmonary disease (HP:0006510)5.64552762
6Obstructive lung disease (HP:0006536)5.64552762
7Mediastinal lymphadenopathy (HP:0100721)5.03252369
8Recurrent skin infections (HP:0001581)4.92490212
9Abnormality of macrophages (HP:0004311)4.83880951
10Recurrent fungal infections (HP:0002841)4.44918896
11Cellulitis (HP:0100658)4.25238000
12Gingivitis (HP:0000230)4.23252035
13Myositis (HP:0100614)4.14588695
14Meningitis (HP:0001287)4.10728286
15Gastrointestinal infarctions (HP:0005244)3.78762642
16T lymphocytopenia (HP:0005403)3.66731750
17Papilledema (HP:0001085)3.53436666
18Stomatitis (HP:0010280)3.44791603
19Abnormality of T cell number (HP:0011839)3.43375001
20Spontaneous hematomas (HP:0007420)3.41659447
21IgM deficiency (HP:0002850)3.38071499
22Urticaria (HP:0001025)3.34300207
23Thrombocytosis (HP:0001894)3.33687135
24Elevated erythrocyte sedimentation rate (HP:0003565)3.29721417
25Recurrent viral infections (HP:0004429)3.28353925
26Recurrent cutaneous fungal infections (HP:0011370)3.19084181
27Chronic mucocutaneous candidiasis (HP:0002728)3.19084181
28Hypochromic microcytic anemia (HP:0004840)3.02273201
29Osteomyelitis (HP:0002754)2.99933757
30Chronic otitis media (HP:0000389)2.97035713
31Severe combined immunodeficiency (HP:0004430)2.93863765
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.86870600
33Vacuolated lymphocytes (HP:0001922)2.82815824
34Orchitis (HP:0100796)2.80816457
35Vasculitis (HP:0002633)2.79665251
36Agnosia (HP:0010524)2.78987162
37Recurrent pneumonia (HP:0006532)2.75094393
38Disinhibition (HP:0000734)2.70389700
39Periodontitis (HP:0000704)2.66799857
40Petechiae (HP:0000967)2.64335639
41Inflammation of the large intestine (HP:0002037)2.62813240
42Abnormality of the prostate (HP:0008775)2.60349677
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.58122049
44Gastrointestinal inflammation (HP:0004386)2.54813260
45Autoimmune hemolytic anemia (HP:0001890)2.54188171
46Episodic fever (HP:0001954)2.53166296
47Hypochromic anemia (HP:0001931)2.51764095
48Sepsis (HP:0100806)2.50049122
49Abnormal platelet volume (HP:0011876)2.49673961
50Abnormality of eosinophils (HP:0001879)2.49381866
51Interstitial pulmonary disease (HP:0006530)2.48633593
52Hematochezia (HP:0002573)2.44481163
53Amyloidosis (HP:0011034)2.43787260
54Retrobulbar optic neuritis (HP:0100654)2.41187242
55Optic neuritis (HP:0100653)2.41187242
56Spinal cord lesions (HP:0100561)2.40130198
57Syringomyelia (HP:0003396)2.40130198
58Pustule (HP:0200039)2.39952924
59Epistaxis (HP:0000421)2.38215275
60Anorexia (HP:0002039)2.38192605
61Abnormality of T cell physiology (HP:0011840)2.37520937
62Recurrent lower respiratory tract infections (HP:0002783)2.37282823
63Chest pain (HP:0100749)2.36578000
64Encephalitis (HP:0002383)2.35669837
65Hypoplasia of the thymus (HP:0000778)2.34908223
66Peritonitis (HP:0002586)2.32613631
67Combined immunodeficiency (HP:0005387)2.32597486
68Leukocytosis (HP:0001974)2.32570029
69Skin rash (HP:0000988)2.32010550
70Gangrene (HP:0100758)2.30880152
71Increased IgM level (HP:0003496)2.29730603
72Hemoptysis (HP:0002105)2.29414740
73Microcytic anemia (HP:0001935)2.28774971
74Recurrent bronchitis (HP:0002837)2.28194646
75Chromsome breakage (HP:0040012)2.27519218
76Colitis (HP:0002583)2.27023631
77Thyroiditis (HP:0100646)2.25183353
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.23156903
79Hypergammaglobulinemia (HP:0010702)2.23041631
80Prolonged bleeding time (HP:0003010)2.22964962
81Keratoconjunctivitis sicca (HP:0001097)2.22622231
82Skin ulcer (HP:0200042)2.20561260
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17063378
84Chronic sinusitis (HP:0011109)2.15954967
85Increased cerebral lipofuscin (HP:0011813)2.15938116
86Viral hepatitis (HP:0006562)2.15269468
87Eosinophilia (HP:0001880)2.14681947
88Long clavicles (HP:0000890)2.13696522
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.12567144
90Lymphopenia (HP:0001888)2.11664338
91IgG deficiency (HP:0004315)2.11575302
92Thoracic kyphosis (HP:0002942)2.11301893
93Abnormality of the thoracic spine (HP:0100711)2.08471986
94Aplasia/Hypoplasia of the thymus (HP:0010515)2.08339859
95Recurrent sinusitis (HP:0011108)2.08210571
96Abnormality of the peritoneum (HP:0002585)2.07167802
97Pulmonary infiltrates (HP:0002113)2.06814932
98Vertigo (HP:0002321)2.06303663
99Dysostosis multiplex (HP:0000943)2.06066168
100Cutaneous melanoma (HP:0012056)2.05418879
101Arterial thrombosis (HP:0004420)2.05094685
102Cheilitis (HP:0100825)2.03616571
103Granulocytopenia (HP:0001913)2.03021623
104Gingival bleeding (HP:0000225)2.01892149
105Amaurosis fugax (HP:0100576)2.00847881
106Keratoconjunctivitis (HP:0001096)1.99303441
107Abnormality of liposaccharide metabolism (HP:0010968)1.99267056
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.99267056
109Abnormality of glycolipid metabolism (HP:0010969)1.99267056
110Agammaglobulinemia (HP:0004432)1.96718280
111Absent frontal sinuses (HP:0002688)1.95283949
112Thickened calvaria (HP:0002684)1.94448991
113Increased mean platelet volume (HP:0011877)1.92913371
114Joint hemorrhage (HP:0005261)1.92480536
115Mucopolysacchariduria (HP:0008155)1.91707524
116Urinary glycosaminoglycan excretion (HP:0003541)1.91707524
117Spondylolisthesis (HP:0003302)1.91249933
118Panhypogammaglobulinemia (HP:0003139)1.91222264
119Hepatosplenomegaly (HP:0001433)1.90135211
120Autoimmune thrombocytopenia (HP:0001973)1.90125691
121Increased IgE level (HP:0003212)1.86775040
122J-shaped sella turcica (HP:0002680)1.86398593
123Abnormality of lateral ventricle (HP:0030047)1.86259344
124Acute lymphatic leukemia (HP:0006721)1.85379953
125Abnormality of the pleura (HP:0002103)1.84817965
126B lymphocytopenia (HP:0010976)1.84687186
127Abnormality of B cell number (HP:0010975)1.84687186
128Verrucae (HP:0200043)1.83628761
129Papilloma (HP:0012740)1.83628761
130Abnormality of T cells (HP:0002843)1.83594699
131Pulmonary embolism (HP:0002204)1.83092789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.95917820
2MAP4K13.52060420
3RIPK43.28624076
4BLK3.23222562
5TEC2.83279381
6BTK2.77898728
7STK102.65281077
8CLK12.50065378
9FES2.36887849
10GRK62.26901154
11EPHB12.10252756
12TRPM72.07443815
13CSK2.04113865
14BMPR21.96842704
15CDK191.93419587
16IRAK31.91372219
17ERN11.89819658
18TYK21.87769488
19TAOK31.83309443
20TESK21.82194193
21BCKDK1.80337749
22MAP2K31.79468323
23KIT1.76743211
24MAP3K141.72823310
25SYK1.64241375
26CSF1R1.61229719
27TRIB31.53990270
28MAP3K121.53916326
29LRRK21.43898400
30FGR1.41281701
31HCK1.37494152
32ITK1.37387219
33MAP3K131.33628155
34TBK11.25819919
35PIM11.25686889
36NEK21.25656621
37LYN1.21826869
38ZAP701.21014584
39PKN21.17994184
40IRAK11.16180531
41PRPF4B1.15874267
42EIF2AK31.10558710
43PAK41.09224243
44IRAK21.06255338
45TESK11.05149814
46RPS6KA41.02714703
47MAP3K81.02176923
48CDC71.02060428
49MAP3K10.97294209
50CDK120.91142415
51MAPK40.89733209
52RPS6KA60.89204684
53PIM20.88345963
54RPS6KC10.87758164
55RPS6KL10.87758164
56LCK0.87387858
57STK40.86753037
58JAK10.85696140
59EEF2K0.84246608
60ALK0.83026542
61BRSK20.82506795
62JAK30.82230780
63IKBKB0.81410567
64TXK0.75840017
65WEE10.74918948
66BUB10.73612224
67IKBKE0.73579860
68TTN0.69103336
69CDK40.68526321
70MAPKAPK20.66549507
71RPS6KA20.65635341
72ATR0.65218735
73JAK20.64161515
74MAP2K40.61625824
75MAP3K110.60948724
76EIF2AK10.60838035
77MARK30.59763340
78SIK30.59245982
79CDK70.57548433
80DAPK20.56288322
81PRKCD0.55792409
82EIF2AK20.55665660
83MATK0.55471675
84CDK60.55426209
85FLT30.55175096
86MAPK120.55134445
87YES10.54723577
88PTK60.53479960
89MAP3K20.51742175
90HIPK20.51409033
91STK110.51327033
92PIK3CG0.51045478
93TNK20.50857296
94FGFR30.50393804
95PDPK10.49895161
96TAOK10.49595469
97ERBB30.48957928
98ABL10.48836321
99KSR20.48478712
100NLK0.48341662
101CCNB10.46317742
102ACVR1B0.46231701
103MAP2K60.45216430
104PRKCQ0.45096709
105PRKG20.44242450
106TAOK20.43903709
107STK240.43777009
108MAP3K100.41951368
109GRK70.41717134
110PRKD20.41606104
111MARK20.41003448
112SIK20.40214568
113PDK10.39228372
114SGK30.36898128
115TGFBR20.36781936
116MAPK70.36617434
117CAMKK20.36541222
118MAP3K30.36521973
119FRK0.35927507
120MAPK110.35613199
121KDR0.34144707
122DYRK30.33880521
123DYRK1B0.33446453
124MAP3K50.32717567
125DMPK0.32040798
126MAP3K70.31469714
127MAP3K60.30686452
128FYN0.29447120
129RET0.28531618
130PTK2B0.27253389
131CHUK0.26617628
132OXSR10.26423583
133PLK10.26209778
134RAF10.25424816

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.82854608
2Autoimmune thyroid disease_Homo sapiens_hsa053202.93760459
3Osteoclast differentiation_Homo sapiens_hsa043802.54894350
4B cell receptor signaling pathway_Homo sapiens_hsa046622.51036299
5Type I diabetes mellitus_Homo sapiens_hsa049402.50607600
6Staphylococcus aureus infection_Homo sapiens_hsa051502.41213651
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35939157
8DNA replication_Homo sapiens_hsa030302.27812012
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.25668542
10Asthma_Homo sapiens_hsa053102.18664452
11Tuberculosis_Homo sapiens_hsa051522.11227560
12Other glycan degradation_Homo sapiens_hsa005112.06352874
13Leukocyte transendothelial migration_Homo sapiens_hsa046702.02525121
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.02515302
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93860673
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79218557
17Legionellosis_Homo sapiens_hsa051341.77812457
18Pertussis_Homo sapiens_hsa051331.77370209
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76139522
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.75774326
21Shigellosis_Homo sapiens_hsa051311.74241898
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67828030
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67289521
24Hematopoietic cell lineage_Homo sapiens_hsa046401.63571705
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.61976395
26Pentose phosphate pathway_Homo sapiens_hsa000301.60933856
27Measles_Homo sapiens_hsa051621.59612417
28Chemokine signaling pathway_Homo sapiens_hsa040621.59219569
29Phagosome_Homo sapiens_hsa041451.54821282
30Primary immunodeficiency_Homo sapiens_hsa053401.53432112
31Mismatch repair_Homo sapiens_hsa034301.44705776
32Herpes simplex infection_Homo sapiens_hsa051681.44574085
33Toxoplasmosis_Homo sapiens_hsa051451.41024389
34Salmonella infection_Homo sapiens_hsa051321.38749723
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38182910
36Lysosome_Homo sapiens_hsa041421.37893061
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33498453
38Apoptosis_Homo sapiens_hsa042101.33051865
39Homologous recombination_Homo sapiens_hsa034401.31011075
40Base excision repair_Homo sapiens_hsa034101.29423000
41Hepatitis B_Homo sapiens_hsa051611.29137330
42Platelet activation_Homo sapiens_hsa046111.25504072
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22679969
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22291038
45Influenza A_Homo sapiens_hsa051641.20080741
46Viral myocarditis_Homo sapiens_hsa054161.17559843
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.16916724
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15533263
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15148648
50Antigen processing and presentation_Homo sapiens_hsa046121.14170867
51Pancreatic cancer_Homo sapiens_hsa052121.14148094
52Cell cycle_Homo sapiens_hsa041101.13323188
53TNF signaling pathway_Homo sapiens_hsa046681.04295240
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03167004
55Acute myeloid leukemia_Homo sapiens_hsa052211.02523045
56p53 signaling pathway_Homo sapiens_hsa041151.01567940
57Fanconi anemia pathway_Homo sapiens_hsa034600.97419877
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.96443761
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96403825
60Epstein-Barr virus infection_Homo sapiens_hsa051690.93668038
61Chronic myeloid leukemia_Homo sapiens_hsa052200.91566906
62Malaria_Homo sapiens_hsa051440.88888508
63Non-small cell lung cancer_Homo sapiens_hsa052230.85663678
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83778476
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82643644
66Non-homologous end-joining_Homo sapiens_hsa034500.79669839
67VEGF signaling pathway_Homo sapiens_hsa043700.78363576
68Viral carcinogenesis_Homo sapiens_hsa052030.74395107
69T cell receptor signaling pathway_Homo sapiens_hsa046600.70646187
70Regulation of autophagy_Homo sapiens_hsa041400.68956436
71Hepatitis C_Homo sapiens_hsa051600.67610840
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.65987715
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63830286
74Nucleotide excision repair_Homo sapiens_hsa034200.62314519
75Graft-versus-host disease_Homo sapiens_hsa053320.62178516
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60220341
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58852547
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58031918
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52467017
80Spliceosome_Homo sapiens_hsa030400.51821775
81Prolactin signaling pathway_Homo sapiens_hsa049170.51750609
82Systemic lupus erythematosus_Homo sapiens_hsa053220.49461117
83HIF-1 signaling pathway_Homo sapiens_hsa040660.49046930
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.48768395
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46885781
86Allograft rejection_Homo sapiens_hsa053300.46852254
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45765713
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45689998
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44884707
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.44604975
91N-Glycan biosynthesis_Homo sapiens_hsa005100.43841219
92Rheumatoid arthritis_Homo sapiens_hsa053230.42908972
93Starch and sucrose metabolism_Homo sapiens_hsa005000.42411161
94Caffeine metabolism_Homo sapiens_hsa002320.41243721
95HTLV-I infection_Homo sapiens_hsa051660.40407516
96Colorectal cancer_Homo sapiens_hsa052100.40039785
97Arachidonic acid metabolism_Homo sapiens_hsa005900.38274624
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37526402
99Dorso-ventral axis formation_Homo sapiens_hsa043200.37473862
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36479158
101Amoebiasis_Homo sapiens_hsa051460.34792789
102Insulin resistance_Homo sapiens_hsa049310.34602466
103Small cell lung cancer_Homo sapiens_hsa052220.34277988
104FoxO signaling pathway_Homo sapiens_hsa040680.33653883
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.32606114
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32438073
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32422436
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31480733
109Inositol phosphate metabolism_Homo sapiens_hsa005620.31347177
110mTOR signaling pathway_Homo sapiens_hsa041500.30785187
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30388907
112Choline metabolism in cancer_Homo sapiens_hsa052310.29713419
113RNA transport_Homo sapiens_hsa030130.29673116
114Ether lipid metabolism_Homo sapiens_hsa005650.29096292
115African trypanosomiasis_Homo sapiens_hsa051430.28858705
116MicroRNAs in cancer_Homo sapiens_hsa052060.28290872
117Endocytosis_Homo sapiens_hsa041440.26749892
118Renal cell carcinoma_Homo sapiens_hsa052110.26009298
119One carbon pool by folate_Homo sapiens_hsa006700.25976091
120Sphingolipid metabolism_Homo sapiens_hsa006000.25303323
121Prostate cancer_Homo sapiens_hsa052150.25120918
122MAPK signaling pathway_Homo sapiens_hsa040100.22592808
123GnRH signaling pathway_Homo sapiens_hsa049120.21281270
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.20688015
125Olfactory transduction_Homo sapiens_hsa047400.20355466
126Notch signaling pathway_Homo sapiens_hsa043300.19453960

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