GAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.07466837
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.88931406
3formation of translation preinitiation complex (GO:0001731)4.86218398
4viral transcription (GO:0019083)4.54531709
5translational termination (GO:0006415)4.43615943
6ribosomal small subunit biogenesis (GO:0042274)4.41156082
7protein localization to kinetochore (GO:0034501)4.38016106
8maturation of SSU-rRNA (GO:0030490)4.35882025
9CENP-A containing nucleosome assembly (GO:0034080)4.33661945
10chromatin remodeling at centromere (GO:0031055)4.30300883
11DNA strand elongation involved in DNA replication (GO:0006271)4.28510785
12DNA unwinding involved in DNA replication (GO:0006268)4.24747412
13chaperone-mediated protein transport (GO:0072321)4.22886699
14establishment of integrated proviral latency (GO:0075713)4.22018108
15ribosomal small subunit assembly (GO:0000028)4.20458118
16telomere maintenance via semi-conservative replication (GO:0032201)4.17603685
17rRNA modification (GO:0000154)4.11382556
18ribosome biogenesis (GO:0042254)4.09833821
19ATP synthesis coupled proton transport (GO:0015986)4.08498174
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.08498174
21proteasome assembly (GO:0043248)4.07384287
22DNA strand elongation (GO:0022616)4.04045976
23translational initiation (GO:0006413)4.03985500
24ribonucleoprotein complex biogenesis (GO:0022613)4.01044138
25translational elongation (GO:0006414)3.99226227
26DNA replication initiation (GO:0006270)3.98042890
27regulation of mitochondrial translation (GO:0070129)3.94129463
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.93635952
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.93222597
30DNA replication checkpoint (GO:0000076)3.91228321
31mitotic sister chromatid segregation (GO:0000070)3.81385238
32mitotic nuclear envelope disassembly (GO:0007077)3.80426465
33folic acid-containing compound biosynthetic process (GO:0009396)3.72401097
34nuclear pore organization (GO:0006999)3.71371345
35protein localization to chromosome, centromeric region (GO:0071459)3.66961153
36negative regulation of RNA splicing (GO:0033119)3.65961064
37ribosomal large subunit biogenesis (GO:0042273)3.64821509
38cellular component biogenesis (GO:0044085)3.64484122
39DNA replication-independent nucleosome organization (GO:0034724)3.63695659
40DNA replication-independent nucleosome assembly (GO:0006336)3.63695659
41nuclear pore complex assembly (GO:0051292)3.59571278
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58244357
43telomere maintenance via recombination (GO:0000722)3.56367597
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.55981740
45termination of RNA polymerase III transcription (GO:0006386)3.55981740
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54788149
47DNA replication-dependent nucleosome assembly (GO:0006335)3.52393202
48DNA replication-dependent nucleosome organization (GO:0034723)3.52393202
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51861703
50rRNA methylation (GO:0031167)3.51056859
51establishment of viral latency (GO:0019043)3.50789212
52nuclear envelope disassembly (GO:0051081)3.50071742
53membrane disassembly (GO:0030397)3.50071742
54histone exchange (GO:0043486)3.49158174
55protein targeting to ER (GO:0045047)3.48302861
56protein targeting to mitochondrion (GO:0006626)3.47047150
57cotranslational protein targeting to membrane (GO:0006613)3.46777780
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.46277523
59viral life cycle (GO:0019058)3.45463269
60negative regulation of mRNA processing (GO:0050686)3.44321549
61heterochromatin organization (GO:0070828)3.43535209
62cellular protein complex disassembly (GO:0043624)3.42829282
63* rRNA processing (GO:0006364)3.42795263
64mitotic metaphase plate congression (GO:0007080)3.41427452
65transcription from mitochondrial promoter (GO:0006390)3.40064131
66mitotic recombination (GO:0006312)3.39399267
67nucleobase biosynthetic process (GO:0046112)3.39133387
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.38318832
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35486591
70sister chromatid segregation (GO:0000819)3.34591835
71* rRNA metabolic process (GO:0016072)3.32081111
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30433444
73telomere maintenance via telomere lengthening (GO:0010833)3.30089449
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29846397
75DNA duplex unwinding (GO:0032508)3.28949599
76regulation of gene silencing by RNA (GO:0060966)3.28453757
77regulation of posttranscriptional gene silencing (GO:0060147)3.28453757
78regulation of gene silencing by miRNA (GO:0060964)3.28453757
79negative regulation of ligase activity (GO:0051352)3.27222681
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27222681
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.27153899
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27153899
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26893877
84DNA geometric change (GO:0032392)3.26023495
85respiratory electron transport chain (GO:0022904)3.25150429
86IMP biosynthetic process (GO:0006188)3.24874773
87spliceosomal snRNP assembly (GO:0000387)3.24693617
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.24662277
89replication fork processing (GO:0031297)3.24100603
90termination of RNA polymerase II transcription (GO:0006369)3.23998334
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.22866393
92protein localization to endoplasmic reticulum (GO:0070972)3.22842485
93protein complex disassembly (GO:0043241)3.22841787
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18881557
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17920425
96DNA topological change (GO:0006265)3.17830250
97ribosome assembly (GO:0042255)3.17286321
98establishment of protein localization to mitochondrion (GO:0072655)3.16468239
99nuclear-transcribed mRNA catabolic process (GO:0000956)3.16309202
100electron transport chain (GO:0022900)3.15547581
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13118790
102transcription-coupled nucleotide-excision repair (GO:0006283)3.12995163
103regulation of translational fidelity (GO:0006450)3.10188864
104protein localization to mitochondrion (GO:0070585)3.09948797
105mitotic G1 DNA damage checkpoint (GO:0031571)3.09718864
106kinetochore organization (GO:0051383)3.08745215
107DNA damage response, detection of DNA damage (GO:0042769)3.08354380
108proline biosynthetic process (GO:0006561)3.08034641
109pre-miRNA processing (GO:0031054)3.06073092
110negative regulation of mRNA metabolic process (GO:1903312)3.05127635
111mitochondrial DNA metabolic process (GO:0032042)3.04978458
112kinetochore assembly (GO:0051382)3.04691777
113oxidative phosphorylation (GO:0006119)3.04185772
114histone H4-K12 acetylation (GO:0043983)3.03871492
115RNA catabolic process (GO:0006401)3.02508805
116chromatin assembly or disassembly (GO:0006333)3.01900491
117DNA-templated transcription, termination (GO:0006353)3.01692920
118RNA splicing, via transesterification reactions (GO:0000375)3.01470056
119mRNA catabolic process (GO:0006402)3.01184550
120mitochondrial RNA metabolic process (GO:0000959)3.00236418
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99943925
122mRNA splicing, via spliceosome (GO:0000398)2.99943925
123macromolecular complex disassembly (GO:0032984)2.99802057
124viral mRNA export from host cell nucleus (GO:0046784)2.97465624
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.97197562
126* ncRNA processing (GO:0034470)2.95490034
127base-excision repair (GO:0006284)2.93181222
128dosage compensation (GO:0007549)2.91360966
129purine nucleobase biosynthetic process (GO:0009113)2.90223830
130maturation of 5.8S rRNA (GO:0000460)2.89530331
131peptidyl-arginine omega-N-methylation (GO:0035247)2.88271273
132* pseudouridine synthesis (GO:0001522)2.87997726
133nuclear envelope organization (GO:0006998)2.87807806
134translation (GO:0006412)2.85743241
135positive regulation of chromosome segregation (GO:0051984)2.85642331
136metaphase plate congression (GO:0051310)2.84799294
137IMP metabolic process (GO:0046040)2.84764783
138mitotic chromosome condensation (GO:0007076)2.83924526
139trophectodermal cell differentiation (GO:0001829)2.83708859
140histone arginine methylation (GO:0034969)2.82776024
141spliceosomal complex assembly (GO:0000245)2.81808149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14273813
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23347535
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68644594
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.64495888
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11684741
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08730129
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03607577
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85160032
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71264126
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69781459
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.39958848
12MYC_22102868_ChIP-Seq_BL_Human2.32077007
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.27993735
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24458865
15XRN2_22483619_ChIP-Seq_HELA_Human2.24370023
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11873001
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.05174485
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04291559
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99680800
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90930155
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88633421
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88036963
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86740550
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85741647
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85741647
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85741647
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.81180684
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80741986
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78409089
30* VDR_23849224_ChIP-Seq_CD4+_Human1.78138722
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77758080
32TTF2_22483619_ChIP-Seq_HELA_Human1.75955449
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.75659302
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.74051827
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73183330
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73137175
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72705257
38GABP_19822575_ChIP-Seq_HepG2_Human1.72506647
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68858061
40DCP1A_22483619_ChIP-Seq_HELA_Human1.68410216
41VDR_21846776_ChIP-Seq_THP-1_Human1.68068760
42FOXP3_21729870_ChIP-Seq_TREG_Human1.63981844
43AR_21909140_ChIP-Seq_LNCAP_Human1.62588959
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58498199
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58148409
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57803217
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.57464520
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57059397
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55672683
50KDM5A_27292631_Chip-Seq_BREAST_Human1.52758710
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50985543
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50848212
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.48983906
54CIITA_25753668_ChIP-Seq_RAJI_Human1.47732747
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40133346
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39164663
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35943212
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34831892
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33876330
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31724360
61ZNF263_19887448_ChIP-Seq_K562_Human1.31565781
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28238658
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27592855
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26054782
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.25980140
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25877907
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25522336
68MYC_18940864_ChIP-ChIP_HL60_Human1.23276379
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19547823
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19334099
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17405254
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16584413
73* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16302753
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16231375
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14084933
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12982039
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11813125
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11414140
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08984977
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.08469446
81TFEB_21752829_ChIP-Seq_HELA_Human1.07385937
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07015783
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06858112
84ELK1_19687146_ChIP-ChIP_HELA_Human1.06110431
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04778328
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03070605
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02737472
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02299768
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01768243
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00991268
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00656571
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99912063
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99698693
94OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99288700
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98448714
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97969769
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97577275
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97081987
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97074273
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96805445
101HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96413364
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95808892
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95076808
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92495558
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92309445
106TCF7_22412390_ChIP-Seq_EML_Mouse0.92177650
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.91236052
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90884544
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90671593
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89636768
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88968108
112POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88613638
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87937954
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87899413
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87017029
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86913212
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86711440
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86471325
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82282618
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.79917399
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78794833
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.78312145
123* FOXP1_21924763_ChIP-Seq_HESCs_Human0.77169721
124CHD1_26751641_Chip-Seq_LNCaP_Human0.76967411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.42744365
2MP0003693_abnormal_embryo_hatching4.36647696
3MP0004957_abnormal_blastocyst_morpholog4.20542082
4MP0003111_abnormal_nucleus_morphology3.84278142
5MP0010094_abnormal_chromosome_stability3.74696863
6MP0009379_abnormal_foot_pigmentation3.61150987
7MP0003077_abnormal_cell_cycle3.41081931
8MP0010352_gastrointestinal_tract_polyps2.81356927
9MP0008058_abnormal_DNA_repair2.47309779
10MP0002396_abnormal_hematopoietic_system2.44627807
11MP0010030_abnormal_orbit_morphology2.31187186
12MP0008932_abnormal_embryonic_tissue2.29854772
13MP0003806_abnormal_nucleotide_metabolis2.28845697
14MP0009697_abnormal_copulation2.27673736
15MP0003186_abnormal_redox_activity2.25535700
16MP0000350_abnormal_cell_proliferation2.24503103
17MP0001730_embryonic_growth_arrest2.22087071
18MP0008007_abnormal_cellular_replicative2.20833140
19MP0000490_abnormal_crypts_of1.99879284
20MP0005380_embryogenesis_phenotype1.98508692
21MP0001672_abnormal_embryogenesis/_devel1.98508692
22MP0003890_abnormal_embryonic-extraembry1.86475630
23MP0003786_premature_aging1.85303101
24MP0001697_abnormal_embryo_size1.85091003
25MP0003941_abnormal_skin_development1.85080852
26MP0003123_paternal_imprinting1.82906328
27MP0003984_embryonic_growth_retardation1.78264311
28MP0002085_abnormal_embryonic_tissue1.77818017
29MP0006036_abnormal_mitochondrial_physio1.76379365
30MP0002088_abnormal_embryonic_growth/wei1.74934940
31MP0009278_abnormal_bone_marrow1.73439798
32MP0002084_abnormal_developmental_patter1.72068611
33MP0002086_abnormal_extraembryonic_tissu1.72016202
34MP0005076_abnormal_cell_differentiation1.71692457
35MP0004197_abnormal_fetal_growth/weight/1.65416038
36MP0005397_hematopoietic_system_phenotyp1.64541334
37MP0001545_abnormal_hematopoietic_system1.64541334
38MP0002080_prenatal_lethality1.63006317
39MP0009333_abnormal_splenocyte_physiolog1.55364287
40MP0000313_abnormal_cell_death1.49975739
41MP0001293_anophthalmia1.49449512
42MP0002877_abnormal_melanocyte_morpholog1.48839612
43MP0002019_abnormal_tumor_incidence1.47441116
44MP0006035_abnormal_mitochondrial_morpho1.46324783
45MP0003567_abnormal_fetal_cardiomyocyte1.45812739
46MP0002653_abnormal_ependyma_morphology1.45244279
47MP0010307_abnormal_tumor_latency1.45212938
48MP0001188_hyperpigmentation1.41348431
49MP0006292_abnormal_olfactory_placode1.37925656
50MP0004808_abnormal_hematopoietic_stem1.32879335
51MP0003119_abnormal_digestive_system1.32440542
52MP0008877_abnormal_DNA_methylation1.26051739
53MP0004264_abnormal_extraembryonic_tissu1.25831635
54MP0004147_increased_porphyrin_level1.22646495
55MP0002796_impaired_skin_barrier1.22207874
56MP0009672_abnormal_birth_weight1.22058322
57MP0003763_abnormal_thymus_physiology1.19740463
58MP0003705_abnormal_hypodermis_morpholog1.19398188
59MP0000703_abnormal_thymus_morphology1.18197872
60MP0005075_abnormal_melanosome_morpholog1.17009804
61MP0001881_abnormal_mammary_gland1.07375170
62MP0001727_abnormal_embryo_implantation1.05601787
63MP0002722_abnormal_immune_system1.04488223
64MP0003718_maternal_effect1.04326514
65MP0002398_abnormal_bone_marrow1.04085190
66MP0004185_abnormal_adipocyte_glucose1.02143800
67MP0009053_abnormal_anal_canal1.01436849
68MP0000689_abnormal_spleen_morphology1.01431496
69MP0004133_heterotaxia1.00350661
70MP0002938_white_spotting0.98425764
71MP0001849_ear_inflammation0.97381216
72MP0002111_abnormal_tail_morphology0.95724573
73MP0005023_abnormal_wound_healing0.95677078
74MP0001929_abnormal_gametogenesis0.92639634
75MP0004233_abnormal_muscle_weight0.91815962
76MP0002160_abnormal_reproductive_system0.91765063
77MP0002932_abnormal_joint_morphology0.91416323
78MP0001145_abnormal_male_reproductive0.89951946
79MP0002092_abnormal_eye_morphology0.89787689
80MP0001764_abnormal_homeostasis0.88533448
81MP0003121_genomic_imprinting0.88089266
82MP0001853_heart_inflammation0.87802513
83MP0002210_abnormal_sex_determination0.87542079
84MP0002697_abnormal_eye_size0.86722710
85MP0005451_abnormal_body_composition0.84443388
86MP0000477_abnormal_intestine_morphology0.83972653
87MP0000372_irregular_coat_pigmentation0.83117183
88MP0000049_abnormal_middle_ear0.82015768
89MP0002132_abnormal_respiratory_system0.81861332
90MP0002163_abnormal_gland_morphology0.81237809
91MP0000428_abnormal_craniofacial_morphol0.80030500
92MP0000358_abnormal_cell_content/0.79988777
93MP0002405_respiratory_system_inflammati0.79591949
94MP0002429_abnormal_blood_cell0.79329005
95MP0008995_early_reproductive_senescence0.78911407
96MP0003315_abnormal_perineum_morphology0.78699986
97MP0002249_abnormal_larynx_morphology0.78511644
98MP0000537_abnormal_urethra_morphology0.77470342
99MP0001529_abnormal_vocalization0.75698820
100MP0000858_altered_metastatic_potential0.73476854
101MP0000432_abnormal_head_morphology0.73212514
102MP0001915_intracranial_hemorrhage0.73150896
103MP0002114_abnormal_axial_skeleton0.73130263
104MP0003935_abnormal_craniofacial_develop0.72291751
105MP0008770_decreased_survivor_rate0.72231529
106MP0005499_abnormal_olfactory_system0.71417382
107MP0005394_taste/olfaction_phenotype0.71417382
108MP0000678_abnormal_parathyroid_gland0.71078491
109MP0003566_abnormal_cell_adhesion0.71072107
110MP0006072_abnormal_retinal_apoptosis0.71040374
111MP0005501_abnormal_skin_physiology0.70199080
112MP0003453_abnormal_keratinocyte_physiol0.69135918
113MP0003385_abnormal_body_wall0.68738846
114MP0005384_cellular_phenotype0.68597901
115MP0003942_abnormal_urinary_system0.68224002
116MP0009703_decreased_birth_body0.67147160
117MP0005621_abnormal_cell_physiology0.67033639
118MP0000653_abnormal_sex_gland0.66624926
119MP0002177_abnormal_outer_ear0.65725584
120MP0002925_abnormal_cardiovascular_devel0.65512443
121MP0001661_extended_life_span0.65355751
122MP0008789_abnormal_olfactory_epithelium0.65273161
123MP0003656_abnormal_erythrocyte_physiolo0.65027258
124MP0001348_abnormal_lacrimal_gland0.64840074
125MP0000716_abnormal_immune_system0.64392588
126MP0005389_reproductive_system_phenotype0.64372205
127MP0003755_abnormal_palate_morphology0.63693961
128MP0000750_abnormal_muscle_regeneration0.63341059
129MP0003221_abnormal_cardiomyocyte_apopto0.62988386
130MP0001286_abnormal_eye_development0.62716713
131MP0002233_abnormal_nose_morphology0.62265088
132MP0005174_abnormal_tail_pigmentation0.61929162
133MP0000685_abnormal_immune_system0.61364629
134MP0000762_abnormal_tongue_morphology0.60837746
135MP0003937_abnormal_limbs/digits/tail_de0.60126814
136MP0003938_abnormal_ear_development0.58904079
137MP0003699_abnormal_female_reproductive0.58103942
138MP0000627_abnormal_mammary_gland0.57939630
139MP0001919_abnormal_reproductive_system0.57162783
140MP0002161_abnormal_fertility/fecundity0.52642346
141MP0002060_abnormal_skin_morphology0.51232844

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57612143
2Abnormality of cells of the erythroid lineage (HP:0012130)4.40554889
3Acute encephalopathy (HP:0006846)4.24971430
4Abnormal mitochondria in muscle tissue (HP:0008316)4.24407751
5Abnormal number of erythroid precursors (HP:0012131)4.16356507
6Reticulocytopenia (HP:0001896)4.01333892
7Increased hepatocellular lipid droplets (HP:0006565)3.90586178
8Mitochondrial inheritance (HP:0001427)3.72836189
9Rib fusion (HP:0000902)3.67966306
10Selective tooth agenesis (HP:0001592)3.61496732
11Increased CSF lactate (HP:0002490)3.59977599
12Progressive macrocephaly (HP:0004481)3.49671584
13Lipid accumulation in hepatocytes (HP:0006561)3.44713004
14Ependymoma (HP:0002888)3.41955350
15Multiple enchondromatosis (HP:0005701)3.36837156
16Cerebral edema (HP:0002181)3.28836387
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26852497
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26852497
19Increased serum pyruvate (HP:0003542)3.26261736
20Hepatocellular necrosis (HP:0001404)3.17609457
21Patellar aplasia (HP:0006443)3.14901696
22Breast hypoplasia (HP:0003187)3.14592324
23Increased serum lactate (HP:0002151)3.13688112
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09309299
25Microvesicular hepatic steatosis (HP:0001414)3.07640036
26Birth length less than 3rd percentile (HP:0003561)3.04774868
27Aplasia/Hypoplasia of the patella (HP:0006498)3.01376302
28Abnormality of glycolysis (HP:0004366)3.00124243
29Trismus (HP:0000211)2.96926102
30Renal Fanconi syndrome (HP:0001994)2.96543210
31Absent thumb (HP:0009777)2.96533435
32Hepatic necrosis (HP:0002605)2.90514389
33Respiratory difficulties (HP:0002880)2.90134216
34Rhabdomyosarcoma (HP:0002859)2.82718184
35Aplasia/hypoplasia of the humerus (HP:0006507)2.81691632
36Pallor (HP:0000980)2.78136739
37Basal cell carcinoma (HP:0002671)2.77672594
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76264446
39Absent radius (HP:0003974)2.74613812
40Chromsome breakage (HP:0040012)2.73754598
41Abnormality of the anterior horn cell (HP:0006802)2.73187551
42Degeneration of anterior horn cells (HP:0002398)2.73187551
43Carpal bone hypoplasia (HP:0001498)2.72961478
44Macrocytic anemia (HP:0001972)2.70862973
45Facial hemangioma (HP:0000329)2.70714082
46Exercise intolerance (HP:0003546)2.69579348
47Increased intramyocellular lipid droplets (HP:0012240)2.68940095
48Abnormality of the ileum (HP:0001549)2.67410561
49Lactic acidosis (HP:0003128)2.66708100
50Abnormal number of incisors (HP:0011064)2.63208764
51Sparse eyelashes (HP:0000653)2.62615373
52Colon cancer (HP:0003003)2.59787639
53Medulloblastoma (HP:0002885)2.59275343
54Concave nail (HP:0001598)2.57537246
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56783159
56Absent forearm bone (HP:0003953)2.54076400
57Aplasia involving forearm bones (HP:0009822)2.54076400
58Poikiloderma (HP:0001029)2.52785666
59Tongue fasciculations (HP:0001308)2.52110149
60Rectal fistula (HP:0100590)2.52022494
61Rectovaginal fistula (HP:0000143)2.52022494
62Abnormality of alanine metabolism (HP:0010916)2.50808207
63Hyperalaninemia (HP:0003348)2.50808207
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50808207
653-Methylglutaconic aciduria (HP:0003535)2.49819553
66Oral leukoplakia (HP:0002745)2.48843796
67Squamous cell carcinoma (HP:0002860)2.48685137
68Meckel diverticulum (HP:0002245)2.47427587
69Neoplasm of striated muscle (HP:0009728)2.43311357
70Short humerus (HP:0005792)2.43140524
71Rough bone trabeculation (HP:0100670)2.41242306
72Myelodysplasia (HP:0002863)2.40225273
73Premature ovarian failure (HP:0008209)2.39850950
74Microretrognathia (HP:0000308)2.39107801
75Intestinal fistula (HP:0100819)2.38158128
76Atresia of the external auditory canal (HP:0000413)2.37874580
77Astrocytoma (HP:0009592)2.36354406
78Abnormality of the astrocytes (HP:0100707)2.36354406
79Impulsivity (HP:0100710)2.36107801
80Aplastic anemia (HP:0001915)2.30177690
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29714426
82Progressive muscle weakness (HP:0003323)2.29692384
83Premature graying of hair (HP:0002216)2.29168470
84Pancytopenia (HP:0001876)2.28030666
85Muscle fibrillation (HP:0010546)2.27563180
86Exertional dyspnea (HP:0002875)2.26085334
87Cleft eyelid (HP:0000625)2.25830247
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25161858
89Missing ribs (HP:0000921)2.24580177
90Homocystinuria (HP:0002156)2.22715432
91Abnormality of homocysteine metabolism (HP:0010919)2.22715432
92Respiratory failure (HP:0002878)2.22643083
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.22431296
94Abnormality of the preputium (HP:0100587)2.21815775
95Increased muscle lipid content (HP:0009058)2.19754818
96Short middle phalanx of the 5th finger (HP:0004220)2.18211511
97Type I transferrin isoform profile (HP:0003642)2.18097752
98Reduced antithrombin III activity (HP:0001976)2.16859540
99Testicular atrophy (HP:0000029)2.16210756
100Hypochromic anemia (HP:0001931)2.15898629
101Vaginal fistula (HP:0004320)2.15667916
102Spinal muscular atrophy (HP:0007269)2.13373176
103Abnormality of the labia minora (HP:0012880)2.13091019
104Abnormality of chromosome stability (HP:0003220)2.09319908
105Megaloblastic anemia (HP:0001889)2.08968776
106Supernumerary spleens (HP:0009799)2.07649599
107Prominent nose (HP:0000448)2.06572091
108Neoplasm of the oral cavity (HP:0100649)2.06523204
109Preauricular skin tag (HP:0000384)2.06308883
110Cellular immunodeficiency (HP:0005374)2.04777191
111Sparse lateral eyebrow (HP:0005338)2.03064062
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01646875
113Abnormal protein N-linked glycosylation (HP:0012347)2.01646875
114Abnormal protein glycosylation (HP:0012346)2.01646875
115Abnormal glycosylation (HP:0012345)2.01646875
116Abnormal hemoglobin (HP:0011902)2.01519524
117Tracheoesophageal fistula (HP:0002575)2.01452209
118Gout (HP:0001997)2.00815732
119Cerebral hypomyelination (HP:0006808)2.00450948
120Annular pancreas (HP:0001734)2.00229581
121Neoplasm of the pancreas (HP:0002894)1.99701983
122Volvulus (HP:0002580)1.99531005
123Small intestinal stenosis (HP:0012848)1.99484956
124Duodenal stenosis (HP:0100867)1.99484956
125Facial cleft (HP:0002006)1.98670150
126Glioma (HP:0009733)1.98509122
127Secondary amenorrhea (HP:0000869)1.97740524
128Ulnar bowing (HP:0003031)1.97256123
129Proximal placement of thumb (HP:0009623)1.97204646
130Abnormal lung lobation (HP:0002101)1.95992914
131Skin tags (HP:0010609)1.95610100
132Leukodystrophy (HP:0002415)1.95397998
133Abnormal umbilical cord blood vessels (HP:0011403)1.94880334
134Single umbilical artery (HP:0001195)1.94880334
135Abnormality of the fetal cardiovascular system (HP:0010948)1.94880334
136Increased nuchal translucency (HP:0010880)1.94087946
137Hypoplasia of the radius (HP:0002984)1.91670706
138Short 5th finger (HP:0009237)1.90376432
139Abnormality of methionine metabolism (HP:0010901)1.89677807
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.89169480
141Lethargy (HP:0001254)1.88038979
142Hypochromic microcytic anemia (HP:0004840)1.88036862
143Abnormal trabecular bone morphology (HP:0100671)1.86039450
144Abnormality of reticulocytes (HP:0004312)1.85339713
145Pustule (HP:0200039)1.85307202
146Glossoptosis (HP:0000162)1.84726940
147IgM deficiency (HP:0002850)1.84258741
148Deviation of the thumb (HP:0009603)1.83841729
149Vertebral fusion (HP:0002948)1.83496202
150Triphalangeal thumb (HP:0001199)1.83271196
151Abnormality of serum amino acid levels (HP:0003112)1.82504984
152Agnosia (HP:0010524)1.81911344
153Horseshoe kidney (HP:0000085)1.81464426
154Bilateral microphthalmos (HP:0007633)1.80663383
155Abnormality of abdominal situs (HP:0011620)1.80622875
156Abdominal situs inversus (HP:0003363)1.80622875
157Progressive external ophthalmoplegia (HP:0000590)1.78834451
15811 pairs of ribs (HP:0000878)1.78467298
159Sensory axonal neuropathy (HP:0003390)1.78304073
160Orthostatic hypotension (HP:0001278)1.78076251
161Postnatal microcephaly (HP:0005484)1.77906499
162Methylmalonic acidemia (HP:0002912)1.77399554
163Truncus arteriosus (HP:0001660)1.77095460
164Abnormality of the umbilical cord (HP:0010881)1.73067219
165Hypertensive crisis (HP:0100735)1.70116697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.71108683
2BUB13.43792668
3CDK123.43628485
4CDC73.33774030
5WEE13.08478150
6PBK2.86835016
7NEK22.58002161
8NME22.54619770
9CDK72.33212526
10TTK2.29665360
11MAP3K102.21809799
12MST42.20841456
13EEF2K2.15878032
14RPS6KB22.05835997
15ICK1.91497095
16PLK11.84338447
17STK101.83810674
18NME11.82033324
19TAF11.80374192
20EIF2AK11.80350815
21MAP3K111.77615139
22PIM21.67330642
23SRPK11.66524597
24PDK21.65952047
25DYRK31.64507931
26EPHA21.58341701
27TESK21.55979942
28ACVR1B1.52913401
29CDK41.52222692
30CHEK21.51334924
31NEK11.50820263
32BCKDK1.48640454
33GRK61.46784494
34PLK41.45071515
35TSSK61.43215705
36AURKB1.40000935
37SMG11.39080763
38ATR1.33172686
39PAK41.31199978
40TLK11.29583229
41ERN11.29361934
42BRSK21.26674530
43MAP4K11.26668049
44MATK1.26643788
45LATS21.26367830
46MKNK11.23640181
47PIM11.22133752
48CHEK11.21149636
49MAP3K81.18623740
50ALK1.16077616
51AURKA1.13089447
52MAP3K61.12017890
53TYRO31.11579127
54IRAK31.08069238
55RPS6KA41.07574761
56NUAK11.06859396
57CDK61.05036213
58TRIB31.04779807
59MKNK21.03335359
60DDR21.03312282
61BRAF1.02141473
62CDK20.97457313
63CCNB10.94597088
64VRK10.90883724
65LRRK20.89893157
66MTOR0.88580716
67ZAK0.87167072
68CLK10.86513435
69PASK0.84070928
70BMX0.84030550
71STK30.81814015
72CSF1R0.81674273
73PKN20.81434530
74MAPKAPK30.80978037
75ATM0.80237283
76BRSK10.72678450
77ARAF0.71347283
78PAK10.69317385
79AKT20.68345294
80CSNK2A20.68256883
81CDK80.68171144
82TGFBR10.67523884
83PLK30.66991978
84EIF2AK20.65739961
85SCYL20.65401420
86STK40.65396825
87ABL20.65132310
88TAOK10.64550810
89EIF2AK30.62989695
90FLT30.62720337
91TRIM280.61043520
92CSNK2A10.60734565
93KDR0.59855018
94PAK20.59014010
95TAOK20.57349711
96STK160.56541784
97SIK30.56538015
98CDK10.55998909
99DYRK20.53963887
100PRKCI0.53569112
101CSK0.53403023
102ERBB40.52767832
103RAF10.52285253
104DAPK10.52235448
105BRD40.51627543
106PRKD20.51034299
107DYRK1B0.50452106
108TESK10.50109640
109MAPK110.48952037
110IRAK40.48872296
111RPS6KL10.46277790
112RPS6KC10.46277790
113CSNK1E0.46130019
114MAP2K30.45531653
115RPS6KA10.45501606
116LATS10.44490697
117HIPK20.42507956
118BTK0.40919339
119ILK0.40739577
120YES10.40685727
121CDK30.40012291
122CDK90.39976006
123MAPK150.39772448
124ZAP700.39057670
125RPS6KA60.38713132
126MAPKAPK20.38702957
127RPS6KA50.35098768
128PRKDC0.31123956
129DMPK0.29366407
130MARK30.28619366
131CSNK1G30.28199982
132PRPF4B0.27103041
133CDK11A0.24705777
134PNCK0.21214881
135CDK140.20792720
136MAPKAPK50.20746941
137CDK150.20406336
138MAPK140.20334514
139CSNK1G10.19941354

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81530136
2Mismatch repair_Homo sapiens_hsa034304.17536434
3Ribosome_Homo sapiens_hsa030104.07729469
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73304147
5Spliceosome_Homo sapiens_hsa030403.48140993
6Base excision repair_Homo sapiens_hsa034103.34183481
7RNA transport_Homo sapiens_hsa030133.22627391
8Homologous recombination_Homo sapiens_hsa034402.70155576
9RNA polymerase_Homo sapiens_hsa030202.69000940
10Oxidative phosphorylation_Homo sapiens_hsa001902.67838908
11Nucleotide excision repair_Homo sapiens_hsa034202.61291922
12Cell cycle_Homo sapiens_hsa041102.50609895
13One carbon pool by folate_Homo sapiens_hsa006702.50074973
14Parkinsons disease_Homo sapiens_hsa050122.39617102
15Proteasome_Homo sapiens_hsa030502.22201954
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09685044
17mRNA surveillance pathway_Homo sapiens_hsa030152.09162465
18Pyrimidine metabolism_Homo sapiens_hsa002402.02842816
19Fanconi anemia pathway_Homo sapiens_hsa034602.00087613
20Protein export_Homo sapiens_hsa030601.98505272
21RNA degradation_Homo sapiens_hsa030181.80287577
22p53 signaling pathway_Homo sapiens_hsa041151.72935776
23Basal transcription factors_Homo sapiens_hsa030221.57108072
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54989325
25Alzheimers disease_Homo sapiens_hsa050101.48235128
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47667519
27Non-homologous end-joining_Homo sapiens_hsa034501.41786690
28Sulfur relay system_Homo sapiens_hsa041221.32710373
29Pyruvate metabolism_Homo sapiens_hsa006201.27038814
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23677701
31Folate biosynthesis_Homo sapiens_hsa007901.07015944
32Epstein-Barr virus infection_Homo sapiens_hsa051691.05042090
33Herpes simplex infection_Homo sapiens_hsa051681.03381792
34Thyroid cancer_Homo sapiens_hsa052161.03280666
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97095474
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96627320
37Vitamin B6 metabolism_Homo sapiens_hsa007500.96483480
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94446523
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94019125
40Biosynthesis of amino acids_Homo sapiens_hsa012300.93512458
41Primary immunodeficiency_Homo sapiens_hsa053400.92423757
42Notch signaling pathway_Homo sapiens_hsa043300.89315578
43Viral carcinogenesis_Homo sapiens_hsa052030.88370273
44HTLV-I infection_Homo sapiens_hsa051660.87376066
45Pentose phosphate pathway_Homo sapiens_hsa000300.87340654
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86893397
47Purine metabolism_Homo sapiens_hsa002300.85297376
48Antigen processing and presentation_Homo sapiens_hsa046120.84974020
49Fatty acid elongation_Homo sapiens_hsa000620.82774100
50MicroRNAs in cancer_Homo sapiens_hsa052060.82523598
51Hippo signaling pathway_Homo sapiens_hsa043900.79978898
52Oocyte meiosis_Homo sapiens_hsa041140.78894630
53Small cell lung cancer_Homo sapiens_hsa052220.78584144
54Basal cell carcinoma_Homo sapiens_hsa052170.76668355
55mTOR signaling pathway_Homo sapiens_hsa041500.75886250
56Fructose and mannose metabolism_Homo sapiens_hsa000510.75322456
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74553266
58Bladder cancer_Homo sapiens_hsa052190.73807728
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73566403
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.73340905
61Acute myeloid leukemia_Homo sapiens_hsa052210.72043922
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69881348
63Propanoate metabolism_Homo sapiens_hsa006400.69367868
64Steroid biosynthesis_Homo sapiens_hsa001000.67730234
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.66975057
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66228207
67Chronic myeloid leukemia_Homo sapiens_hsa052200.65966273
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63762901
69Colorectal cancer_Homo sapiens_hsa052100.63403326
70Metabolic pathways_Homo sapiens_hsa011000.63090125
71Hedgehog signaling pathway_Homo sapiens_hsa043400.62643985
72Cardiac muscle contraction_Homo sapiens_hsa042600.62130050
73TGF-beta signaling pathway_Homo sapiens_hsa043500.60557459
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59133821
75Selenocompound metabolism_Homo sapiens_hsa004500.58563763
76Legionellosis_Homo sapiens_hsa051340.57967265
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57321563
78Apoptosis_Homo sapiens_hsa042100.54962195
79Shigellosis_Homo sapiens_hsa051310.54681335
80Galactose metabolism_Homo sapiens_hsa000520.54520603
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48074005
82Hepatitis B_Homo sapiens_hsa051610.47752549
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.47058038
84Sulfur metabolism_Homo sapiens_hsa009200.46697813
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.44639548
86Adherens junction_Homo sapiens_hsa045200.44194896
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43803334
88Systemic lupus erythematosus_Homo sapiens_hsa053220.41935541
89Viral myocarditis_Homo sapiens_hsa054160.41911613
90Pathways in cancer_Homo sapiens_hsa052000.41236114
91Wnt signaling pathway_Homo sapiens_hsa043100.41068085
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38211198
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37586304
94N-Glycan biosynthesis_Homo sapiens_hsa005100.36512711
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36191799
96Measles_Homo sapiens_hsa051620.35230137
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32087093
98Non-small cell lung cancer_Homo sapiens_hsa052230.31331911
99Lysine degradation_Homo sapiens_hsa003100.30926344
100VEGF signaling pathway_Homo sapiens_hsa043700.29646073
101Glutathione metabolism_Homo sapiens_hsa004800.28882667
102HIF-1 signaling pathway_Homo sapiens_hsa040660.27822233
103B cell receptor signaling pathway_Homo sapiens_hsa046620.27238602
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.27222959
105Fatty acid biosynthesis_Homo sapiens_hsa000610.26496023
106Carbon metabolism_Homo sapiens_hsa012000.25950839
107Pancreatic cancer_Homo sapiens_hsa052120.25790044
108Proteoglycans in cancer_Homo sapiens_hsa052050.25660955
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25085188
110Arginine and proline metabolism_Homo sapiens_hsa003300.23215924
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22843291
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.21334713
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20632984
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20238814
115Prostate cancer_Homo sapiens_hsa052150.19668549
116Huntingtons disease_Homo sapiens_hsa050160.19433656
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19299761
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18933821
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18871542
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18061503
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17577437
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17311202
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17181082
124Fatty acid metabolism_Homo sapiens_hsa012120.12780789
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11938214
126Vitamin digestion and absorption_Homo sapiens_hsa049770.10978392
127Tyrosine metabolism_Homo sapiens_hsa003500.10894914
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09460829
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07809890
130Peroxisome_Homo sapiens_hsa041460.05318607
131Melanoma_Homo sapiens_hsa052180.04483142
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.03374560
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.02145956

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