GAREM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)6.56640444
2keratinocyte development (GO:0003334)6.51440173
3centrosome localization (GO:0051642)5.03378381
4regulation of autophagic vacuole assembly (GO:2000785)4.92025909
5regulation of protein polyubiquitination (GO:1902914)4.65907102
6presynaptic membrane assembly (GO:0097105)4.50627928
7postsynaptic membrane organization (GO:0001941)4.24480539
8negative regulation of gluconeogenesis (GO:0045721)4.23841986
9regulation of vacuole organization (GO:0044088)4.00350108
10neurotransmitter-gated ion channel clustering (GO:0072578)3.98401615
11SMAD protein complex assembly (GO:0007183)3.88240918
12presynaptic membrane organization (GO:0097090)3.86888707
13positive regulation of neurological system process (GO:0031646)3.79735728
14transepithelial transport (GO:0070633)3.76426788
15embryonic retina morphogenesis in camera-type eye (GO:0060059)3.57043316
16piRNA metabolic process (GO:0034587)3.54350149
17positive regulation of insulin receptor signaling pathway (GO:0046628)3.46098559
18pyrimidine nucleobase catabolic process (GO:0006208)3.42889388
19suckling behavior (GO:0001967)3.38577845
20cerebral cortex cell migration (GO:0021795)3.37482423
21intraciliary transport (GO:0042073)3.34342357
22cerebral cortex radially oriented cell migration (GO:0021799)3.32915114
23vocalization behavior (GO:0071625)3.21108368
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15267994
25nucleobase catabolic process (GO:0046113)3.13801342
26neuron cell-cell adhesion (GO:0007158)3.04818436
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00733556
28dendritic spine morphogenesis (GO:0060997)2.95696741
29central nervous system projection neuron axonogenesis (GO:0021952)2.89174501
30negative regulation of macroautophagy (GO:0016242)2.88199236
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87599544
32axonal fasciculation (GO:0007413)2.87586335
33regulation of respiratory system process (GO:0044065)2.82702923
34startle response (GO:0001964)2.80949233
35negative regulation of astrocyte differentiation (GO:0048712)2.78391739
36apical protein localization (GO:0045176)2.74119878
37substrate-independent telencephalic tangential migration (GO:0021826)2.72527817
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72527817
39positive regulation of dendritic spine morphogenesis (GO:0061003)2.69964177
40telencephalon cell migration (GO:0022029)2.69875700
41morphogenesis of an epithelial sheet (GO:0002011)2.64891291
42forebrain cell migration (GO:0021885)2.62257265
43neuron recognition (GO:0008038)2.61739771
44dendrite morphogenesis (GO:0048813)2.61206527
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59775041
46limb development (GO:0060173)2.56126626
47appendage development (GO:0048736)2.56126626
48regulation of macroautophagy (GO:0016241)2.55878579
49positive regulation of organelle assembly (GO:1902117)2.55669099
50camera-type eye morphogenesis (GO:0048593)2.53875527
51positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.51740211
52positive regulation of synapse assembly (GO:0051965)2.50094234
53central nervous system neuron axonogenesis (GO:0021955)2.48411786
54auditory receptor cell differentiation (GO:0042491)2.47509803
55positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46796411
56inositol phosphate catabolic process (GO:0071545)2.46080113
57retina layer formation (GO:0010842)2.37792544
58protein localization to synapse (GO:0035418)2.37568612
59behavioral response to nicotine (GO:0035095)2.36860169
60smoothened signaling pathway (GO:0007224)2.35612346
61neural precursor cell proliferation (GO:0061351)2.35403426
62positive regulation of dendritic spine development (GO:0060999)2.35204811
63axon ensheathment in central nervous system (GO:0032291)2.35108727
64central nervous system myelination (GO:0022010)2.35108727
65negative regulation of keratinocyte proliferation (GO:0010839)2.33320862
66desmosome organization (GO:0002934)2.32842123
67limb bud formation (GO:0060174)2.32792885
68Sertoli cell development (GO:0060009)2.31636087
69asymmetric protein localization (GO:0008105)2.31046128
70regulation of dendritic spine morphogenesis (GO:0061001)2.30652648
71calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29572597
72regulation of heart rate by cardiac conduction (GO:0086091)2.27536665
73gene silencing by RNA (GO:0031047)2.26567624
74DNA methylation involved in gamete generation (GO:0043046)2.26467666
75neuron fate determination (GO:0048664)2.24980698
76cell communication involved in cardiac conduction (GO:0086065)2.24948722
77membrane assembly (GO:0071709)2.24446681
78positive regulation of cellular response to insulin stimulus (GO:1900078)2.22361753
79cilium assembly (GO:0042384)2.22231822
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.21548037
81forebrain neuron development (GO:0021884)2.21541018
82regulation of pigment cell differentiation (GO:0050932)2.20739629
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.20487573
84nephron tubule development (GO:0072080)2.20273346
85embryonic body morphogenesis (GO:0010172)2.19997919
86otic vesicle formation (GO:0030916)2.18648019
87cilium organization (GO:0044782)2.18163904
88auditory behavior (GO:0031223)2.17176891
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.17036897
90transmission of nerve impulse (GO:0019226)2.16006869
91detection of mechanical stimulus involved in sensory perception (GO:0050974)2.15933997
92inositol phosphate dephosphorylation (GO:0046855)2.15858063
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.15858063
94multicellular organismal signaling (GO:0035637)2.15213638
95regulation of respiratory gaseous exchange (GO:0043576)2.13729279
96cardiac conduction (GO:0061337)2.12356031
97cochlea development (GO:0090102)2.10931333
98ephrin receptor signaling pathway (GO:0048013)2.10546511
99male meiosis I (GO:0007141)2.09531506
100cardiac muscle cell action potential (GO:0086001)2.09418387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.32854356
2GBX2_23144817_ChIP-Seq_PC3_Human2.64074987
3VDR_22108803_ChIP-Seq_LS180_Human2.45274828
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29769449
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18493876
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14486407
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12890852
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05978749
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.05393256
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01819074
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92310489
12SMAD4_21799915_ChIP-Seq_A2780_Human1.90954400
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.89580103
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82388909
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82217282
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81682963
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80815646
18P300_19829295_ChIP-Seq_ESCs_Human1.77821058
19IGF1R_20145208_ChIP-Seq_DFB_Human1.77380469
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75427636
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73731722
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70724500
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68107950
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.65547330
25BCAT_22108803_ChIP-Seq_LS180_Human1.64434047
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.63738708
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63511229
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62460341
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.62165524
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61545384
31FUS_26573619_Chip-Seq_HEK293_Human1.61441083
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58875855
33AR_25329375_ChIP-Seq_VCAP_Human1.56422851
34TAF15_26573619_Chip-Seq_HEK293_Human1.55138069
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54977635
36GATA1_22025678_ChIP-Seq_K562_Human1.52594055
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52302250
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50728234
39STAT3_23295773_ChIP-Seq_U87_Human1.50355368
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41705820
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.40654148
42TP53_18474530_ChIP-ChIP_U2OS_Human1.40644419
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40638946
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40638946
45DROSHA_22980978_ChIP-Seq_HELA_Human1.40311568
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38801755
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37120824
48REST_21632747_ChIP-Seq_MESCs_Mouse1.36717732
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.36396646
50RNF2_27304074_Chip-Seq_NSC_Mouse1.36224694
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31505358
52ZNF274_21170338_ChIP-Seq_K562_Hela1.30777232
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.29457121
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29249484
55TCF4_23295773_ChIP-Seq_U87_Human1.27213646
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27089795
57TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26018199
58TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25479020
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24505473
60STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24421322
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.24203901
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22175037
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21038913
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20975461
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20629047
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20546165
67TCF4_22108803_ChIP-Seq_LS180_Human1.20222116
68RUNX2_22187159_ChIP-Seq_PCA_Human1.19557900
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19019888
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.18754657
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18452648
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15957887
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15381103
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15381103
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14897127
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.14364709
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.14331017
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13593125
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13408312
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.13386407
81EWS_26573619_Chip-Seq_HEK293_Human1.12800863
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12409788
83TP53_16413492_ChIP-PET_HCT116_Human1.11829134
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10688582
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09354813
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08767230
87AHR_22903824_ChIP-Seq_MCF-7_Human1.08714757
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08696592
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06737322
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06420883
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06181636
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.05985165
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05754675
94ER_23166858_ChIP-Seq_MCF-7_Human1.05322273
95SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03476282
96AR_21572438_ChIP-Seq_LNCaP_Human1.03230230
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02834525
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02834525
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.02686444
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.02574578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.52553622
2MP0003880_abnormal_central_pattern2.78767761
3MP0004270_analgesia2.52562506
4MP0000566_synostosis2.48452279
5MP0008877_abnormal_DNA_methylation2.32065395
6MP0000778_abnormal_nervous_system2.23774968
7MP0004859_abnormal_synaptic_plasticity2.05069965
8MP0009780_abnormal_chondrocyte_physiolo2.02171118
9MP0006292_abnormal_olfactory_placode1.96298180
10MP0004142_abnormal_muscle_tone1.84278674
11MP0003136_yellow_coat_color1.77086888
12MP0003283_abnormal_digestive_organ1.74852557
13MP0002249_abnormal_larynx_morphology1.70785905
14MP0010234_abnormal_vibrissa_follicle1.69900011
15MP0005409_darkened_coat_color1.68866909
16MP0002876_abnormal_thyroid_physiology1.64150804
17MP0010678_abnormal_skin_adnexa1.60133776
18MP0000383_abnormal_hair_follicle1.57937523
19MP0008789_abnormal_olfactory_epithelium1.57694871
20MP0002734_abnormal_mechanical_nocicepti1.56010243
21MP0010030_abnormal_orbit_morphology1.55270464
22MP0004885_abnormal_endolymph1.53995795
23MP0001486_abnormal_startle_reflex1.50743800
24MP0002233_abnormal_nose_morphology1.48269869
25MP0000049_abnormal_middle_ear1.48056140
26MP0005174_abnormal_tail_pigmentation1.42386382
27MP0002272_abnormal_nervous_system1.41115038
28MP0000427_abnormal_hair_cycle1.40049125
29MP0001188_hyperpigmentation1.38878362
30MP0005499_abnormal_olfactory_system1.35868143
31MP0005394_taste/olfaction_phenotype1.35868143
32MP0002938_white_spotting1.35125024
33MP0001485_abnormal_pinna_reflex1.33552083
34MP0003755_abnormal_palate_morphology1.32416200
35MP0009046_muscle_twitch1.32328884
36MP0003937_abnormal_limbs/digits/tail_de1.31585306
37MP0003635_abnormal_synaptic_transmissio1.29443210
38MP0002909_abnormal_adrenal_gland1.29027184
39MP0000579_abnormal_nail_morphology1.25452497
40MP0001529_abnormal_vocalization1.24402902
41MP0005187_abnormal_penis_morphology1.23476395
42MP0000647_abnormal_sebaceous_gland1.22327611
43MP0002064_seizures1.20207392
44MP0004924_abnormal_behavior1.18991307
45MP0005386_behavior/neurological_phenoty1.18991307
46MP0005551_abnormal_eye_electrophysiolog1.18881185
47MP0002102_abnormal_ear_morphology1.18811494
48MP0002063_abnormal_learning/memory/cond1.18133420
49MP0000631_abnormal_neuroendocrine_gland1.16190799
50MP0009745_abnormal_behavioral_response1.14447933
51MP0006276_abnormal_autonomic_nervous1.13628080
52MP0001299_abnormal_eye_distance/1.13289099
53MP0000026_abnormal_inner_ear1.12103998
54MP0003878_abnormal_ear_physiology1.09960786
55MP0005377_hearing/vestibular/ear_phenot1.09960786
56MP0003890_abnormal_embryonic-extraembry1.08777781
57MP0002557_abnormal_social/conspecific_i1.08629794
58MP0000762_abnormal_tongue_morphology1.08590900
59MP0005646_abnormal_pituitary_gland1.08112071
60MP0003122_maternal_imprinting1.07484348
61MP0002735_abnormal_chemical_nociception1.06869377
62MP0005423_abnormal_somatic_nervous1.04130447
63MP0000569_abnormal_digit_pigmentation1.03950046
64MP0000537_abnormal_urethra_morphology1.02037568
65MP0001968_abnormal_touch/_nociception0.96381792
66MP0000534_abnormal_ureter_morphology0.95633324
67MP0009250_abnormal_appendicular_skeleto0.94305367
68MP0005248_abnormal_Harderian_gland0.93736311
69MP0003938_abnormal_ear_development0.93240536
70MP0000639_abnormal_adrenal_gland0.92214629
71MP0004133_heterotaxia0.91212070
72MP0002572_abnormal_emotion/affect_behav0.90054468
73MP0002184_abnormal_innervation0.89894616
74MP0003935_abnormal_craniofacial_develop0.89573364
75MP0002882_abnormal_neuron_morphology0.89131021
76MP0003942_abnormal_urinary_system0.88548428
77MP0003861_abnormal_nervous_system0.86907255
78MP0000955_abnormal_spinal_cord0.85764506
79MP0003787_abnormal_imprinting0.85516570
80MP0002234_abnormal_pharynx_morphology0.84887335
81MP0001293_anophthalmia0.84450245
82MP0009053_abnormal_anal_canal0.83639649
83MP0002152_abnormal_brain_morphology0.83066262
84MP0001501_abnormal_sleep_pattern0.82815851
85MP0002067_abnormal_sensory_capabilities0.82698406
86MP0003121_genomic_imprinting0.82456562
87MP0005408_hypopigmentation0.82278347
88MP0002736_abnormal_nociception_after0.80878314
89MP0002638_abnormal_pupillary_reflex0.80784000
90MP0004019_abnormal_vitamin_homeostasis0.80397684
91MP0002116_abnormal_craniofacial_bone0.80232246
92MP0002796_impaired_skin_barrier0.80058542
93MP0005275_abnormal_skin_tensile0.79634554
94MP0005365_abnormal_bile_salt0.78764065
95MP0002229_neurodegeneration0.77735187
96MP0001756_abnormal_urination0.76844447
97MP0001970_abnormal_pain_threshold0.76356030
98MP0003868_abnormal_feces_composition0.75448773
99MP0002752_abnormal_somatic_nervous0.74127549
100MP0001286_abnormal_eye_development0.73481449

Predicted human phenotypes

RankGene SetZ-score
1Infantile muscular hypotonia (HP:0008947)4.16730678
2Focal motor seizures (HP:0011153)4.04688415
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.45640557
4Short 4th metacarpal (HP:0010044)3.45640557
5Hyperventilation (HP:0002883)3.23109212
6Lissencephaly (HP:0001339)3.13971476
7Brushfield spots (HP:0001088)3.07184034
8Aplasia/Hypoplasia of the tibia (HP:0005772)2.97231439
9Short tibia (HP:0005736)2.89530526
10Focal seizures (HP:0007359)2.89497041
11Fibular hypoplasia (HP:0003038)2.86967708
12Abnormality of the 4th metacarpal (HP:0010012)2.75606050
13Optic nerve hypoplasia (HP:0000609)2.71285043
14Type II lissencephaly (HP:0007260)2.59728295
15Hypoplastic labia majora (HP:0000059)2.55755879
16Tibial bowing (HP:0002982)2.55105356
17Osteomalacia (HP:0002749)2.50080643
18Cutaneous finger syndactyly (HP:0010554)2.49734621
19Labial hypoplasia (HP:0000066)2.47807263
20Myokymia (HP:0002411)2.45306322
21Hypoplastic female external genitalia (HP:0012815)2.39988257
22Abnormality of the labia minora (HP:0012880)2.36968020
23Abnormality of the labia majora (HP:0012881)2.25774989
24Septo-optic dysplasia (HP:0100842)2.25008984
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24589873
26Action tremor (HP:0002345)2.23910016
27Aplasia/Hypoplasia of the fibula (HP:0006492)2.21583572
28Tubular atrophy (HP:0000092)2.16198457
29Absence seizures (HP:0002121)2.14104757
30Radial bowing (HP:0002986)2.13109093
31Drooling (HP:0002307)2.12256628
32Cerebellar dysplasia (HP:0007033)2.09430462
33Coronal craniosynostosis (HP:0004440)2.09277315
34Hemiparesis (HP:0001269)2.05160965
35Cutaneous syndactyly (HP:0012725)2.03389435
36Mesomelia (HP:0003027)2.02594186
37Hypoplasia of the pons (HP:0012110)2.01482250
38Dialeptic seizures (HP:0011146)2.00823061
39Thickened nuchal skin fold (HP:0000474)1.99186839
40Tubulointerstitial nephritis (HP:0001970)1.97570225
41Broad-based gait (HP:0002136)1.92935246
42Abnormality of the pons (HP:0007361)1.90326762
43Aplasia involving bones of the upper limbs (HP:0009823)1.89283068
44Aplasia of the phalanges of the hand (HP:0009802)1.89283068
45Aplasia involving bones of the extremities (HP:0009825)1.89283068
46Abnormality of the ischium (HP:0003174)1.88225176
47Polymicrogyria (HP:0002126)1.88091279
48Abnormality of the diencephalon (HP:0010662)1.84509449
49Hypoplasia of the ulna (HP:0003022)1.80230977
50Hypoplastic ischia (HP:0003175)1.79839483
51Excessive salivation (HP:0003781)1.78939445
52Generalized tonic-clonic seizures (HP:0002069)1.78633162
53Abnormality of the labia (HP:0000058)1.76981575
54Hyperactive renin-angiotensin system (HP:0000841)1.76862346
55Hyperaldosteronism (HP:0000859)1.76233336
56Abnormality of midbrain morphology (HP:0002418)1.75047541
57Molar tooth sign on MRI (HP:0002419)1.75047541
58Bowed forearm bones (HP:0003956)1.72546152
59Bowing of the arm (HP:0006488)1.72546152
60Macroorchidism (HP:0000053)1.69705379
61Abnormality of chloride homeostasis (HP:0011422)1.68259172
62Exotropia (HP:0000577)1.67566261
63Tubulointerstitial abnormality (HP:0001969)1.67525066
64Atonic seizures (HP:0010819)1.67040771
65Febrile seizures (HP:0002373)1.66726953
66CNS hypomyelination (HP:0003429)1.66447919
67Pancreatic fibrosis (HP:0100732)1.65155043
68Syncope (HP:0001279)1.62585663
69Oligodactyly (hands) (HP:0001180)1.61803722
70Abnormality of the fibula (HP:0002991)1.60868963
71Volvulus (HP:0002580)1.60687952
72Megalencephaly (HP:0001355)1.60208561
73Aplasia/Hypoplasia of the ulna (HP:0006495)1.59449431
74Pancreatic cysts (HP:0001737)1.59406393
75Bronchomalacia (HP:0002780)1.58682489
76Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.58487705
77Progressive cerebellar ataxia (HP:0002073)1.58179148
78Genital tract atresia (HP:0001827)1.58061368
79Chronic hepatic failure (HP:0100626)1.57500438
80Metabolic alkalosis (HP:0200114)1.57207254
81Abnormal ciliary motility (HP:0012262)1.57049179
82True hermaphroditism (HP:0010459)1.56717742
83Calf muscle hypertrophy (HP:0008981)1.56449618
84Hepatoblastoma (HP:0002884)1.56394523
85Increased circulating renin level (HP:0000848)1.56190257
86Generalized myoclonic seizures (HP:0002123)1.55793027
87Vaginal atresia (HP:0000148)1.55172833
88Maternal diabetes (HP:0009800)1.54106754
89Prolonged QT interval (HP:0001657)1.53951593
90Tracheomalacia (HP:0002779)1.52136284
91Abnormality of the vitreous humor (HP:0004327)1.52134905
92Retinal dysplasia (HP:0007973)1.51983751
93Renal hypoplasia (HP:0000089)1.51834396
94Confusion (HP:0001289)1.50833931
95Sclerocornea (HP:0000647)1.49952499
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.49881025
97Absent/shortened dynein arms (HP:0200106)1.49881025
98Impaired social interactions (HP:0000735)1.49584840
99Abnormal social behavior (HP:0012433)1.49584840
100Abnormal drinking behavior (HP:0030082)1.49277536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.53368231
2CASK3.15094958
3PNCK2.82429468
4EPHB22.57545045
5NTRK32.56109268
6NME12.55954865
7FRK2.53341746
8TNIK2.44728996
9MARK12.42969453
10WNK32.31676011
11TYRO32.28776488
12PAK61.97188893
13PINK11.95225997
14EPHA41.92555014
15STK391.87599973
16MAP3K41.66408978
17KSR11.61932648
18PAK31.54406538
19MET1.53327827
20SGK21.49565208
21MAP3K71.43487983
22NTRK21.42900619
23SGK2231.35582044
24SGK4941.35582044
25MOS1.35285554
26STK38L1.32049660
27STK241.31094243
28TRIM281.28948934
29MAPK131.27385241
30FGFR21.20525010
31BCR1.16539996
32BMPR1B1.14927022
33MAP2K71.09109167
34WNK41.08016604
35KSR21.06210111
36PIK3CA1.00210287
37OXSR10.94331774
38NTRK10.92784144
39CAMK1G0.87263894
40SGK30.86304710
41DYRK20.85454520
42EPHA20.81872076
43PDGFRB0.81443886
44NLK0.81038919
45AKT30.80074786
46DMPK0.78932761
47YES10.77243438
48GRK10.76344337
49LATS10.75139801
50CSNK1G10.75015027
51UHMK10.73709128
52MUSK0.72278554
53OBSCN0.71832165
54PRKCG0.69783254
55RPS6KB10.67832768
56NUAK10.66582895
57PHKG20.66338951
58PHKG10.66338951
59BRD40.64398447
60STK30.64041326
61PLK20.64009122
62PRKCE0.62919969
63MAP3K20.62346987
64STK110.61992738
65MST1R0.60751292
66CAMK2A0.60279504
67CSNK1G20.59246361
68CAMK2D0.58022364
69SGK10.56991120
70LMTK20.55969098
71ERBB20.54778591
72PTK20.54574052
73FGFR10.53132650
74MINK10.51917103
75CDK50.51852295
76MKNK20.51076232
77PRKAA20.49813179
78ARAF0.48996167
79RAF10.47524876
80PRPF4B0.44798123
81ROCK10.44028852
82CAMK10.43979351
83NEK60.43374853
84PKN10.41392519
85GSK3A0.40642731
86FER0.40005170
87PDK20.39404301
88PRKCZ0.39285721
89TAOK10.38910027
90RPS6KA30.38121846
91CSNK1E0.37786525
92WEE10.37729127
93PLK10.37715959
94TAOK20.37630026
95DYRK1A0.36447502
96INSRR0.36020581
97PRKACA0.35961691
98BRSK20.35649075
99CSNK1A10.35449732
100CCNB10.34566555

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.37241524
2Phototransduction_Homo sapiens_hsa047441.97538531
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92227614
4Propanoate metabolism_Homo sapiens_hsa006401.73623107
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72909067
6Linoleic acid metabolism_Homo sapiens_hsa005911.67586235
7Fat digestion and absorption_Homo sapiens_hsa049751.66227414
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.65051410
9Insulin secretion_Homo sapiens_hsa049111.64139107
10Gastric acid secretion_Homo sapiens_hsa049711.63129121
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62065311
12Butanoate metabolism_Homo sapiens_hsa006501.52628151
13Dorso-ventral axis formation_Homo sapiens_hsa043201.50067069
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.45935564
15Histidine metabolism_Homo sapiens_hsa003401.39234230
16Pancreatic secretion_Homo sapiens_hsa049721.39026408
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38984906
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37973353
19Adherens junction_Homo sapiens_hsa045201.37841238
20Glutamatergic synapse_Homo sapiens_hsa047241.34905148
21Cocaine addiction_Homo sapiens_hsa050301.32914304
22Circadian rhythm_Homo sapiens_hsa047101.30809299
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30308233
24Circadian entrainment_Homo sapiens_hsa047131.29471841
25Axon guidance_Homo sapiens_hsa043601.28927193
26Hedgehog signaling pathway_Homo sapiens_hsa043401.26649133
27beta-Alanine metabolism_Homo sapiens_hsa004101.25107059
28Tight junction_Homo sapiens_hsa045301.21895360
29Protein digestion and absorption_Homo sapiens_hsa049741.20701012
30Basal cell carcinoma_Homo sapiens_hsa052171.20387098
31Fatty acid degradation_Homo sapiens_hsa000711.19476133
32Long-term depression_Homo sapiens_hsa047301.19312946
33Cardiac muscle contraction_Homo sapiens_hsa042601.17833007
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17812231
35Hippo signaling pathway_Homo sapiens_hsa043901.17149821
36Amphetamine addiction_Homo sapiens_hsa050311.15448593
37Peroxisome_Homo sapiens_hsa041461.14771129
38Fanconi anemia pathway_Homo sapiens_hsa034601.13796359
39Retinol metabolism_Homo sapiens_hsa008301.11321474
40Chemical carcinogenesis_Homo sapiens_hsa052041.10687328
41Tryptophan metabolism_Homo sapiens_hsa003801.08397947
42Bile secretion_Homo sapiens_hsa049761.08297462
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06100964
44Salivary secretion_Homo sapiens_hsa049701.01836747
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01083951
46Nitrogen metabolism_Homo sapiens_hsa009101.00984823
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00800674
48Cholinergic synapse_Homo sapiens_hsa047251.00220392
49Dopaminergic synapse_Homo sapiens_hsa047280.97027118
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96403573
51Caffeine metabolism_Homo sapiens_hsa002320.94835691
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92442944
53TGF-beta signaling pathway_Homo sapiens_hsa043500.92288066
54Serotonergic synapse_Homo sapiens_hsa047260.91789127
55Lysine degradation_Homo sapiens_hsa003100.90701010
56GABAergic synapse_Homo sapiens_hsa047270.90349068
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89752884
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89673474
59Steroid biosynthesis_Homo sapiens_hsa001000.88795832
60Taste transduction_Homo sapiens_hsa047420.87429779
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87029258
62Glycerolipid metabolism_Homo sapiens_hsa005610.86824086
63Mineral absorption_Homo sapiens_hsa049780.86421379
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85603641
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84969024
66Melanogenesis_Homo sapiens_hsa049160.84925703
67Wnt signaling pathway_Homo sapiens_hsa043100.81991394
68Thyroid hormone synthesis_Homo sapiens_hsa049180.81551631
69Ether lipid metabolism_Homo sapiens_hsa005650.81229957
70cAMP signaling pathway_Homo sapiens_hsa040240.80445689
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.79120388
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78780117
73RNA degradation_Homo sapiens_hsa030180.78475939
74Fatty acid metabolism_Homo sapiens_hsa012120.77525961
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77048823
76Sphingolipid metabolism_Homo sapiens_hsa006000.74773711
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74380740
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74210338
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.73989008
80Ovarian steroidogenesis_Homo sapiens_hsa049130.73626718
81Morphine addiction_Homo sapiens_hsa050320.72226960
82Oxytocin signaling pathway_Homo sapiens_hsa049210.71203363
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69987945
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69956490
85Dilated cardiomyopathy_Homo sapiens_hsa054140.69403077
86ErbB signaling pathway_Homo sapiens_hsa040120.68766812
87Choline metabolism in cancer_Homo sapiens_hsa052310.67308573
88Gap junction_Homo sapiens_hsa045400.67256766
89Long-term potentiation_Homo sapiens_hsa047200.66191262
90Arachidonic acid metabolism_Homo sapiens_hsa005900.66152287
91ECM-receptor interaction_Homo sapiens_hsa045120.64897236
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61901899
93Folate biosynthesis_Homo sapiens_hsa007900.61248770
94Calcium signaling pathway_Homo sapiens_hsa040200.60820161
95Renin secretion_Homo sapiens_hsa049240.60714746
96Arginine and proline metabolism_Homo sapiens_hsa003300.59606556
97PPAR signaling pathway_Homo sapiens_hsa033200.58439797
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57134000
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56204200
100Starch and sucrose metabolism_Homo sapiens_hsa005000.55191793

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