GAREM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)5.74240614
2presynaptic membrane assembly (GO:0097105)5.11718987
3presynaptic membrane organization (GO:0097090)5.11159744
4pyrimidine nucleobase catabolic process (GO:0006208)4.53968366
5neuron cell-cell adhesion (GO:0007158)4.30478571
6behavioral response to nicotine (GO:0035095)4.19517947
7central nervous system myelination (GO:0022010)3.87990582
8axon ensheathment in central nervous system (GO:0032291)3.87990582
9transmission of nerve impulse (GO:0019226)3.73382134
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.71299039
11dendritic spine morphogenesis (GO:0060997)3.63427608
12nucleobase catabolic process (GO:0046113)3.59202569
13vocalization behavior (GO:0071625)3.56142373
14axonal fasciculation (GO:0007413)3.52351315
15neuron recognition (GO:0008038)3.51727875
16auditory behavior (GO:0031223)3.51667972
17forebrain neuron differentiation (GO:0021879)3.38685210
18mechanosensory behavior (GO:0007638)3.36236662
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35826718
20cell proliferation in forebrain (GO:0021846)3.29650386
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28466063
22regulation of synapse structural plasticity (GO:0051823)3.28063898
23protein localization to synapse (GO:0035418)3.21217060
24positive regulation of synapse assembly (GO:0051965)3.17775347
25retinal ganglion cell axon guidance (GO:0031290)3.15277640
26gamma-aminobutyric acid transport (GO:0015812)3.12018876
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07549606
28locomotory exploration behavior (GO:0035641)3.07538013
29positive regulation of gastrulation (GO:2000543)3.07339506
30establishment of mitochondrion localization (GO:0051654)3.05171186
31nonmotile primary cilium assembly (GO:0035058)3.03632109
32ionotropic glutamate receptor signaling pathway (GO:0035235)2.98473391
33spinal cord development (GO:0021510)2.96961531
34synaptic transmission, glutamatergic (GO:0035249)2.95652524
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92088627
36cell migration in hindbrain (GO:0021535)2.89299822
37regulation of respiratory system process (GO:0044065)2.87079007
38synapse assembly (GO:0007416)2.86906526
39synaptic vesicle maturation (GO:0016188)2.86403108
40central nervous system projection neuron axonogenesis (GO:0021952)2.85388240
41exploration behavior (GO:0035640)2.85060699
42neurotransmitter-gated ion channel clustering (GO:0072578)2.84966409
43regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83023679
44neuronal stem cell maintenance (GO:0097150)2.82394711
45neuronal action potential propagation (GO:0019227)2.80557798
46thalamus development (GO:0021794)2.78776966
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75485371
48regulation of glutamate receptor signaling pathway (GO:1900449)2.69888517
49response to auditory stimulus (GO:0010996)2.67943949
50neuromuscular synaptic transmission (GO:0007274)2.66818154
51urogenital system development (GO:0001655)2.66553893
52adult walking behavior (GO:0007628)2.66124243
53limb development (GO:0060173)2.62191424
54appendage development (GO:0048736)2.62191424
55dermatan sulfate biosynthetic process (GO:0030208)2.60946842
56neuronal ion channel clustering (GO:0045161)2.60850875
57cranial nerve development (GO:0021545)2.60402223
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59678926
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.56735139
60substrate-independent telencephalic tangential migration (GO:0021826)2.56735139
61negative regulation of axon extension (GO:0030517)2.56694837
62limb bud formation (GO:0060174)2.55107366
63cerebellar granule cell differentiation (GO:0021707)2.53699986
64dendrite morphogenesis (GO:0048813)2.53615362
65synaptic transmission, cholinergic (GO:0007271)2.53612116
66olfactory bulb development (GO:0021772)2.53542156
67regulation of neurotransmitter uptake (GO:0051580)2.53065589
68negative regulation of astrocyte differentiation (GO:0048712)2.52434397
69cerebellar Purkinje cell differentiation (GO:0021702)2.51891004
70glutamate receptor signaling pathway (GO:0007215)2.51727886
71negative regulation of oligodendrocyte differentiation (GO:0048715)2.50518619
72hippocampus development (GO:0021766)2.50134593
73head development (GO:0060322)2.48717278
74cerebellum development (GO:0021549)2.48626640
75regulation of synapse assembly (GO:0051963)2.48067844
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47059299
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.46904685
78startle response (GO:0001964)2.46806709
79spinal cord association neuron differentiation (GO:0021527)2.44682936
80negative regulation of axon guidance (GO:1902668)2.43700607
81synapse organization (GO:0050808)2.42932574
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.42267853
83mitochondrion transport along microtubule (GO:0047497)2.42267853
84neuron-neuron synaptic transmission (GO:0007270)2.42091503
85cell differentiation in hindbrain (GO:0021533)2.42035280
86neuron fate determination (GO:0048664)2.41097666
87neurotransmitter secretion (GO:0007269)2.40132936
88negative regulation of glial cell differentiation (GO:0045686)2.40005281
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39738764
90behavioral response to cocaine (GO:0048148)2.37449827
91regulation of respiratory gaseous exchange (GO:0043576)2.37030588
92membrane repolarization (GO:0086009)2.36664827
93tongue development (GO:0043586)2.35964614
94negative regulation of axonogenesis (GO:0050771)2.35748006
95C4-dicarboxylate transport (GO:0015740)2.35283907
96cerebral cortex radially oriented cell migration (GO:0021799)2.35188444
97cell differentiation in spinal cord (GO:0021515)2.34542897
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34043347
99establishment of nucleus localization (GO:0040023)2.33137486
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.32747703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.97392585
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.51761029
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.83485481
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72010807
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.66901431
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61145074
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60909539
8REST_21632747_ChIP-Seq_MESCs_Mouse2.52659255
9GBX2_23144817_ChIP-Seq_PC3_Human2.40678081
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.40054306
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35850900
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28749124
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26138906
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25488548
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.23910961
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.20776682
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17761561
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17761561
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15560208
20ZNF274_21170338_ChIP-Seq_K562_Hela2.14450994
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05480607
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03548292
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98192636
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.95927219
25IGF1R_20145208_ChIP-Seq_DFB_Human1.81713870
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80723268
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79798279
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79038734
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78394441
30RNF2_27304074_Chip-Seq_NSC_Mouse1.76840604
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73887135
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73348149
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70210210
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68974134
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67486005
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62586935
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.61837436
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58215616
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57809846
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54904006
41VDR_22108803_ChIP-Seq_LS180_Human1.46625834
42DROSHA_22980978_ChIP-Seq_HELA_Human1.43544764
43AR_21572438_ChIP-Seq_LNCaP_Human1.41052744
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37943133
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36396993
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36396993
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.34578385
48FUS_26573619_Chip-Seq_HEK293_Human1.32805453
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27024078
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26765114
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26257730
52EWS_26573619_Chip-Seq_HEK293_Human1.24964577
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24647092
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24066183
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.22623850
56P300_19829295_ChIP-Seq_ESCs_Human1.21647804
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.19146893
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17557525
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.16283654
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.15415636
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13611280
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10420353
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09996046
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.08901982
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07172028
66TAF15_26573619_Chip-Seq_HEK293_Human1.06829814
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06496801
68SMAD4_21799915_ChIP-Seq_A2780_Human1.06021776
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.04849320
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04694301
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04512702
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04392970
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.04369046
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03744848
75SMAD3_21741376_ChIP-Seq_ESCs_Human1.03682472
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03585666
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.02921982
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02123711
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00343835
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97980772
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97767115
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97755501
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96822528
84SOX9_26525672_Chip-Seq_HEART_Mouse0.96584643
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.96361536
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96197564
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93312928
88AR_25329375_ChIP-Seq_VCAP_Human0.93274911
89IRF1_19129219_ChIP-ChIP_H3396_Human0.91121117
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90962432
91AR_19668381_ChIP-Seq_PC3_Human0.90447800
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89275509
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87323943
94CTCF_27219007_Chip-Seq_Bcells_Human0.87174308
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86769099
96STAT3_23295773_ChIP-Seq_U87_Human0.86706913
97SOX2_21211035_ChIP-Seq_LN229_Gbm0.85397792
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85073980
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84913469
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84842279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.66717103
2MP0003136_yellow_coat_color3.66325590
3MP0006292_abnormal_olfactory_placode3.09451681
4MP0000778_abnormal_nervous_system2.73495165
5MP0002653_abnormal_ependyma_morphology2.67808906
6MP0005423_abnormal_somatic_nervous2.63310054
7MP0004859_abnormal_synaptic_plasticity2.57239257
8MP0003635_abnormal_synaptic_transmissio2.18515597
9MP0001968_abnormal_touch/_nociception2.18199653
10MP0001984_abnormal_olfaction2.07510276
11MP0006276_abnormal_autonomic_nervous2.05739948
12MP0004885_abnormal_endolymph2.04388991
13MP0004270_analgesia1.94729967
14MP0002736_abnormal_nociception_after1.94641872
15MP0002272_abnormal_nervous_system1.94183254
16MP0009745_abnormal_behavioral_response1.86719349
17MP0002063_abnormal_learning/memory/cond1.83822423
18MP0000955_abnormal_spinal_cord1.80663503
19MP0002734_abnormal_mechanical_nocicepti1.76931812
20MP0002064_seizures1.74166042
21MP0001188_hyperpigmentation1.73892027
22MP0001486_abnormal_startle_reflex1.73287276
23MP0003787_abnormal_imprinting1.70025800
24MP0000049_abnormal_middle_ear1.65937669
25MP0002184_abnormal_innervation1.65679338
26MP0002638_abnormal_pupillary_reflex1.65538900
27MP0002572_abnormal_emotion/affect_behav1.65173632
28MP0003890_abnormal_embryonic-extraembry1.60096632
29MP0002557_abnormal_social/conspecific_i1.58381145
30MP0008789_abnormal_olfactory_epithelium1.57868301
31MP0001529_abnormal_vocalization1.57588097
32MP0005394_taste/olfaction_phenotype1.55399965
33MP0005499_abnormal_olfactory_system1.55399965
34MP0000631_abnormal_neuroendocrine_gland1.50501624
35MP0001485_abnormal_pinna_reflex1.49191359
36MP0005171_absent_coat_pigmentation1.49127033
37MP0001970_abnormal_pain_threshold1.48438625
38MP0008877_abnormal_DNA_methylation1.47865616
39MP0002735_abnormal_chemical_nociception1.47774041
40MP0004133_heterotaxia1.47720929
41MP0005551_abnormal_eye_electrophysiolog1.46975693
42MP0002882_abnormal_neuron_morphology1.43709104
43MP0003122_maternal_imprinting1.43112638
44MP0005646_abnormal_pituitary_gland1.40373497
45MP0001502_abnormal_circadian_rhythm1.37084364
46MP0003938_abnormal_ear_development1.35972309
47MP0000026_abnormal_inner_ear1.35576089
48MP0004142_abnormal_muscle_tone1.35559487
49MP0002152_abnormal_brain_morphology1.32532469
50MP0003861_abnormal_nervous_system1.32155412
51MP0002733_abnormal_thermal_nociception1.31216785
52MP0009046_muscle_twitch1.29218201
53MP0001293_anophthalmia1.28574602
54MP0003121_genomic_imprinting1.27604813
55MP0002752_abnormal_somatic_nervous1.26229740
56MP0002234_abnormal_pharynx_morphology1.22165610
57MP0001986_abnormal_taste_sensitivity1.21331971
58MP0002067_abnormal_sensory_capabilities1.20356007
59MP0004811_abnormal_neuron_physiology1.19845701
60MP0002102_abnormal_ear_morphology1.18650977
61MP0003119_abnormal_digestive_system1.16390031
62MP0009379_abnormal_foot_pigmentation1.15294494
63MP0002938_white_spotting1.12571326
64MP0006072_abnormal_retinal_apoptosis1.12048901
65MP0002822_catalepsy1.07886757
66MP0005253_abnormal_eye_physiology1.07617078
67MP0001963_abnormal_hearing_physiology1.06075227
68MP0004742_abnormal_vestibular_system1.05272946
69MP0005174_abnormal_tail_pigmentation1.05167683
70MP0002751_abnormal_autonomic_nervous1.03451196
71MP0002249_abnormal_larynx_morphology1.03005783
72MP0001286_abnormal_eye_development1.00806928
73MP0005195_abnormal_posterior_eye0.98990187
74MP0001346_abnormal_lacrimal_gland0.98186164
75MP0003942_abnormal_urinary_system0.97452248
76MP0010030_abnormal_orbit_morphology0.97231066
77MP0003123_paternal_imprinting0.94601894
78MP0003755_abnormal_palate_morphology0.94403178
79MP0003937_abnormal_limbs/digits/tail_de0.93752344
80MP0001299_abnormal_eye_distance/0.93650941
81MP0001905_abnormal_dopamine_level0.93628955
82MP0002066_abnormal_motor_capabilities/c0.93535454
83MP0003283_abnormal_digestive_organ0.92377467
84MP0000534_abnormal_ureter_morphology0.91408509
85MP0002233_abnormal_nose_morphology0.91347454
86MP0001440_abnormal_grooming_behavior0.86146727
87MP0002697_abnormal_eye_size0.86056708
88MP0009250_abnormal_appendicular_skeleto0.85219317
89MP0004924_abnormal_behavior0.85161666
90MP0005386_behavior/neurological_phenoty0.85161666
91MP0005391_vision/eye_phenotype0.85126282
92MP0000566_synostosis0.83560711
93MP0002909_abnormal_adrenal_gland0.83477758
94MP0002160_abnormal_reproductive_system0.81936122
95MP0005187_abnormal_penis_morphology0.81315524
96MP0002928_abnormal_bile_duct0.79098247
97MP0003385_abnormal_body_wall0.77565730
98MP0002116_abnormal_craniofacial_bone0.76544006
99MP0008569_lethality_at_weaning0.76292958
100MP0003879_abnormal_hair_cell0.75650610

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.61123127
2Oligodactyly (hands) (HP:0001180)3.46895397
3Myokymia (HP:0002411)3.19683205
4Rib fusion (HP:0000902)3.09129815
5Focal motor seizures (HP:0011153)2.85580157
6Optic nerve hypoplasia (HP:0000609)2.78169608
7Oligodactyly (HP:0012165)2.73612430
8Molar tooth sign on MRI (HP:0002419)2.68968070
9Abnormality of midbrain morphology (HP:0002418)2.68968070
10Abnormality of the labia minora (HP:0012880)2.67595168
11Focal seizures (HP:0007359)2.63530669
12True hermaphroditism (HP:0010459)2.61354696
13Progressive cerebellar ataxia (HP:0002073)2.58235328
14Split foot (HP:0001839)2.54479228
15Hyperventilation (HP:0002883)2.53766923
16Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48185345
17Anophthalmia (HP:0000528)2.48119572
18Pancreatic fibrosis (HP:0100732)2.43702062
19Nephronophthisis (HP:0000090)2.42971376
20Hemiparesis (HP:0001269)2.36709784
21Megalencephaly (HP:0001355)2.36235026
22Pancreatic cysts (HP:0001737)2.31573999
23Gait imbalance (HP:0002141)2.30746923
24Patellar aplasia (HP:0006443)2.30169796
25Medial flaring of the eyebrow (HP:0010747)2.24924141
26Type II lissencephaly (HP:0007260)2.20398993
27Intestinal atresia (HP:0011100)2.19167264
28Sclerocornea (HP:0000647)2.17282722
29Epileptic encephalopathy (HP:0200134)2.17111380
30Genital tract atresia (HP:0001827)2.16484662
31Vaginal atresia (HP:0000148)2.14199765
32Colon cancer (HP:0003003)2.13756184
33Esophageal atresia (HP:0002032)2.13286815
34Absent septum pellucidum (HP:0001331)2.12679916
35Retinal dysplasia (HP:0007973)2.12634286
36Aplasia/Hypoplasia of the patella (HP:0006498)2.08137802
37Gastrointestinal atresia (HP:0002589)2.06623214
38Anomalous pulmonary venous return (HP:0010772)2.06199715
39Lissencephaly (HP:0001339)2.05614538
40Drooling (HP:0002307)2.04516006
41Pachygyria (HP:0001302)2.00303610
42Chronic hepatic failure (HP:0100626)1.99749152
43Congenital primary aphakia (HP:0007707)1.97617928
44Cerebellar dysplasia (HP:0007033)1.96996415
45Supernumerary spleens (HP:0009799)1.95359813
46Hepatoblastoma (HP:0002884)1.94926167
47Limb dystonia (HP:0002451)1.94290353
48Congenital stationary night blindness (HP:0007642)1.91381529
49Abnormality of the renal medulla (HP:0100957)1.91244521
50Abnormality of the diencephalon (HP:0010662)1.90066631
51Cutaneous finger syndactyly (HP:0010554)1.89067018
52Anencephaly (HP:0002323)1.88902564
53Hypoplastic pelvis (HP:0008839)1.86711911
54Morphological abnormality of the inner ear (HP:0011390)1.86202781
55Broad-based gait (HP:0002136)1.85746972
56Hemivertebrae (HP:0002937)1.85680675
57Asplenia (HP:0001746)1.85032528
58Specific learning disability (HP:0001328)1.84952852
59Bony spicule pigmentary retinopathy (HP:0007737)1.84708997
60Aplasia/Hypoplasia of the sternum (HP:0006714)1.84698848
61Shawl scrotum (HP:0000049)1.84466425
62Febrile seizures (HP:0002373)1.83667768
63Aplasia/Hypoplasia of the spleen (HP:0010451)1.83562475
64Nephrogenic diabetes insipidus (HP:0009806)1.81365177
65Polyphagia (HP:0002591)1.80406637
66Maternal diabetes (HP:0009800)1.78244955
67Meningocele (HP:0002435)1.77588689
68Postaxial hand polydactyly (HP:0001162)1.77554070
69Excessive salivation (HP:0003781)1.76549935
70Abnormality of the 4th metacarpal (HP:0010012)1.74814879
71Preaxial hand polydactyly (HP:0001177)1.73950165
72Polydipsia (HP:0001959)1.73135880
73Abnormal drinking behavior (HP:0030082)1.73135880
74Abnormality of the septum pellucidum (HP:0007375)1.71732827
75Absent speech (HP:0001344)1.71085313
76Action tremor (HP:0002345)1.70928556
77Renal hypoplasia (HP:0000089)1.70444102
78Cystic liver disease (HP:0006706)1.70257527
79Genetic anticipation (HP:0003743)1.69417966
80Cutaneous syndactyly (HP:0012725)1.69322244
81Poor coordination (HP:0002370)1.68584707
82Abnormality of the pulmonary veins (HP:0011718)1.68418323
83Occipital encephalocele (HP:0002085)1.68400798
84Renal dysplasia (HP:0000110)1.67781676
85Abnormal eating behavior (HP:0100738)1.65834418
86Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63528846
87Generalized tonic-clonic seizures (HP:0002069)1.63527426
88Partial duplication of thumb phalanx (HP:0009944)1.62587940
89Attenuation of retinal blood vessels (HP:0007843)1.59831693
90Holoprosencephaly (HP:0001360)1.59354553
91Pendular nystagmus (HP:0012043)1.58524163
92Congenital malformation of the right heart (HP:0011723)1.58518091
93Double outlet right ventricle (HP:0001719)1.58518091
94Cortical dysplasia (HP:0002539)1.58153083
95Atonic seizures (HP:0010819)1.57805501
96Tubular atrophy (HP:0000092)1.57170769
97Chorioretinal atrophy (HP:0000533)1.55282767
98Sleep apnea (HP:0010535)1.54606273
99Abnormality of the corticospinal tract (HP:0002492)1.54371800
100Narrow forehead (HP:0000341)1.54293518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.98015918
2MARK13.81972821
3NTRK22.73588910
4PNCK2.54363780
5TNIK2.52748736
6MAP3K42.39181365
7NTRK32.37727920
8DYRK22.30766418
9EPHA42.18148458
10WNK31.99899670
11PRKD31.92800133
12MAPK151.90620460
13MAPK131.89977740
14MAP2K71.79189972
15WNK41.76076408
16TYRO31.70119189
17PINK11.61083363
18STK161.57686934
19BMPR1B1.55506084
20EPHB21.53608344
21CSNK1G21.53013507
22MINK11.51883313
23PRKCG1.50360053
24FRK1.43646085
25MKNK21.37502252
26FGFR21.35844212
27ADRBK21.31641724
28CSNK1G31.16828813
29PLK21.16768063
30TAF11.16364540
31SIK21.15722210
32PKN11.15493880
33SGK4941.13213428
34SGK2231.13213428
35CAMK1G1.09361548
36UHMK11.07828929
37DAPK21.05638642
38CSNK1A1L1.04842647
39CSNK1G11.04617207
40PAK61.02964722
41PHKG10.97289817
42PHKG20.97289817
43WNK10.96757191
44MAP2K40.95767186
45DYRK1A0.88443690
46CAMK1D0.88342564
47PAK30.88092773
48DYRK30.86431477
49SGK20.84564765
50STK110.84499822
51GRK10.83773386
52STK390.83472813
53BCR0.83264636
54STK38L0.82849023
55NTRK10.82619252
56CDK50.79953117
57DYRK1B0.78517658
58MAP4K20.77206777
59PRKCH0.76758221
60VRK10.75389820
61WEE10.73799711
62MKNK10.73503717
63ZAK0.73237667
64CDC70.72499253
65CAMK10.71840822
66CDK190.69411649
67KSR10.68115715
68PLK40.65693914
69CAMKK10.65292839
70CAMK2A0.62036505
71NUAK10.60143345
72INSRR0.60002126
73MAP3K90.59606497
74PRKCZ0.59448015
75MAP3K100.58071263
76ERBB20.58052612
77CAMK40.57038542
78PLK30.57022080
79CSNK1E0.56336737
80PRKCE0.51908174
81MAPKAPK50.50969144
82PLK10.50014299
83CDK150.49867615
84ADRBK10.49097461
85BRSK10.47815415
86CDK11A0.47536787
87CSNK1D0.46942934
88CDK180.46832451
89AURKA0.45619634
90NEK20.44762058
91CAMK2B0.44187914
92TRIM280.44038361
93CDK140.43431833
94MARK20.43403694
95SGK10.43239279
96PRKDC0.42022494
97CSNK1A10.41778008
98ATR0.39937686
99SGK30.39805268
100PRKACA0.39390393

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57813384
2Morphine addiction_Homo sapiens_hsa050322.20743678
3GABAergic synapse_Homo sapiens_hsa047272.20570739
4Basal cell carcinoma_Homo sapiens_hsa052172.12535132
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03279333
6Glutamatergic synapse_Homo sapiens_hsa047242.02401623
7Hedgehog signaling pathway_Homo sapiens_hsa043401.95834256
8Circadian entrainment_Homo sapiens_hsa047131.95303008
9Phototransduction_Homo sapiens_hsa047441.94339384
10Insulin secretion_Homo sapiens_hsa049111.93885198
11Cardiac muscle contraction_Homo sapiens_hsa042601.88017175
12Axon guidance_Homo sapiens_hsa043601.83220115
13Cocaine addiction_Homo sapiens_hsa050301.75672890
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70841620
15Dopaminergic synapse_Homo sapiens_hsa047281.67759149
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61995133
17Oxidative phosphorylation_Homo sapiens_hsa001901.58033672
18Synaptic vesicle cycle_Homo sapiens_hsa047211.55442703
19Parkinsons disease_Homo sapiens_hsa050121.54327058
20Amphetamine addiction_Homo sapiens_hsa050311.52065454
21Hippo signaling pathway_Homo sapiens_hsa043901.50877549
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48860748
23Taste transduction_Homo sapiens_hsa047421.43778492
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40556947
25Cholinergic synapse_Homo sapiens_hsa047251.35224828
26Fanconi anemia pathway_Homo sapiens_hsa034601.33437456
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32804854
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32637146
29Basal transcription factors_Homo sapiens_hsa030221.25016081
30Melanogenesis_Homo sapiens_hsa049161.24089042
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22586104
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22272944
33Gastric acid secretion_Homo sapiens_hsa049711.19371224
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19188659
35Wnt signaling pathway_Homo sapiens_hsa043101.17991080
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17070865
37Olfactory transduction_Homo sapiens_hsa047401.16485843
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16412698
39Huntingtons disease_Homo sapiens_hsa050161.15626880
40Butanoate metabolism_Homo sapiens_hsa006501.15356734
41Homologous recombination_Homo sapiens_hsa034401.12156186
42Steroid biosynthesis_Homo sapiens_hsa001001.10840549
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10058827
44Serotonergic synapse_Homo sapiens_hsa047261.09503118
45Long-term depression_Homo sapiens_hsa047301.09230984
46cAMP signaling pathway_Homo sapiens_hsa040241.08968596
47Alzheimers disease_Homo sapiens_hsa050101.03791126
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.02903850
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02123619
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99086371
51Oxytocin signaling pathway_Homo sapiens_hsa049210.91920430
52Calcium signaling pathway_Homo sapiens_hsa040200.91910518
53Propanoate metabolism_Homo sapiens_hsa006400.89952167
54Dorso-ventral axis formation_Homo sapiens_hsa043200.88546691
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87634024
56Gap junction_Homo sapiens_hsa045400.87354642
57Salivary secretion_Homo sapiens_hsa049700.86704738
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86460878
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83117392
60Notch signaling pathway_Homo sapiens_hsa043300.81892707
61RNA polymerase_Homo sapiens_hsa030200.81210450
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80835245
63Protein export_Homo sapiens_hsa030600.79849810
64Ribosome_Homo sapiens_hsa030100.77186200
65Nitrogen metabolism_Homo sapiens_hsa009100.75813404
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72624677
67Alcoholism_Homo sapiens_hsa050340.68191625
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66824618
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65641838
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63594963
71Sulfur relay system_Homo sapiens_hsa041220.62950587
72Oocyte meiosis_Homo sapiens_hsa041140.61470355
73Thyroid hormone synthesis_Homo sapiens_hsa049180.60478396
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59160057
75Long-term potentiation_Homo sapiens_hsa047200.58553221
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57901059
77Ether lipid metabolism_Homo sapiens_hsa005650.55647972
78Fatty acid metabolism_Homo sapiens_hsa012120.54230656
79Lysine degradation_Homo sapiens_hsa003100.52886309
80RNA degradation_Homo sapiens_hsa030180.52343510
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51324680
82Ovarian steroidogenesis_Homo sapiens_hsa049130.50542331
83Linoleic acid metabolism_Homo sapiens_hsa005910.50162511
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49441440
85Collecting duct acid secretion_Homo sapiens_hsa049660.48563009
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48294396
87Renin secretion_Homo sapiens_hsa049240.47994110
88Selenocompound metabolism_Homo sapiens_hsa004500.47059494
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46975413
90Ras signaling pathway_Homo sapiens_hsa040140.46730113
91MAPK signaling pathway_Homo sapiens_hsa040100.46360903
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45617209
93Circadian rhythm_Homo sapiens_hsa047100.44594041
94mRNA surveillance pathway_Homo sapiens_hsa030150.43374379
95Rap1 signaling pathway_Homo sapiens_hsa040150.42523386
96Bile secretion_Homo sapiens_hsa049760.41921317
97beta-Alanine metabolism_Homo sapiens_hsa004100.39436403
98Melanoma_Homo sapiens_hsa052180.39357392
99ErbB signaling pathway_Homo sapiens_hsa040120.39121949
100Arginine and proline metabolism_Homo sapiens_hsa003300.39094700

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