GARNL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56501140
2neuronal action potential propagation (GO:0019227)5.34796142
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18089965
4synaptic vesicle exocytosis (GO:0016079)5.14083434
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12588005
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.04246641
7vocalization behavior (GO:0071625)5.01124986
8synaptic vesicle maturation (GO:0016188)4.86597927
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80976230
10glutamate secretion (GO:0014047)4.80512613
11neuron cell-cell adhesion (GO:0007158)4.69617509
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.62832646
13regulation of synaptic vesicle exocytosis (GO:2000300)4.61947908
14glutamate receptor signaling pathway (GO:0007215)4.60217929
15locomotory exploration behavior (GO:0035641)4.58823812
16synaptic transmission, glutamatergic (GO:0035249)4.58534955
17protein localization to synapse (GO:0035418)4.55765451
18regulation of glutamate receptor signaling pathway (GO:1900449)4.42776979
19cerebellar granule cell differentiation (GO:0021707)4.34588045
20neuron-neuron synaptic transmission (GO:0007270)4.26412609
21cerebellar Purkinje cell differentiation (GO:0021702)4.24511879
22neurotransmitter secretion (GO:0007269)4.23315882
23regulation of synaptic vesicle transport (GO:1902803)4.16966032
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16712370
25gamma-aminobutyric acid transport (GO:0015812)4.00913851
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.00863020
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.98911250
28neurotransmitter-gated ion channel clustering (GO:0072578)3.95502012
29pyrimidine nucleobase catabolic process (GO:0006208)3.94175460
30positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.88852740
31synaptic vesicle endocytosis (GO:0048488)3.88341676
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.82170057
33regulation of neurotransmitter secretion (GO:0046928)3.77747965
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77599209
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75500166
36membrane depolarization during action potential (GO:0086010)3.69316645
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65896825
38regulation of postsynaptic membrane potential (GO:0060078)3.65220788
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.64741442
40presynaptic membrane assembly (GO:0097105)3.62314015
41behavioral response to nicotine (GO:0035095)3.61306265
42neurotransmitter transport (GO:0006836)3.61300224
43regulation of neuronal synaptic plasticity (GO:0048168)3.59404998
44presynaptic membrane organization (GO:0097090)3.58528037
45long-term memory (GO:0007616)3.57649463
46exploration behavior (GO:0035640)3.56751448
47postsynaptic membrane organization (GO:0001941)3.56218076
48transmission of nerve impulse (GO:0019226)3.54205095
49regulation of synapse structural plasticity (GO:0051823)3.53608840
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.51351337
51nucleobase catabolic process (GO:0046113)3.48842213
52regulation of neurotransmitter transport (GO:0051588)3.47878553
53cellular potassium ion homeostasis (GO:0030007)3.47519653
54membrane depolarization (GO:0051899)3.46186214
55neuromuscular process controlling posture (GO:0050884)3.46032527
56positive regulation of membrane potential (GO:0045838)3.43249168
57cell differentiation in hindbrain (GO:0021533)3.43161872
58auditory behavior (GO:0031223)3.42507375
59positive regulation of synapse maturation (GO:0090129)3.40941631
60C4-dicarboxylate transport (GO:0015740)3.39632090
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.39323671
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38376157
63layer formation in cerebral cortex (GO:0021819)3.37152392
64L-amino acid import (GO:0043092)3.33035325
65neuron recognition (GO:0008038)3.31903267
66regulation of neurotransmitter levels (GO:0001505)3.27693636
67response to auditory stimulus (GO:0010996)3.27313960
68regulation of synapse maturation (GO:0090128)3.24926301
69membrane hyperpolarization (GO:0060081)3.23717629
70proline transport (GO:0015824)3.23629126
71mechanosensory behavior (GO:0007638)3.22640036
72regulation of vesicle fusion (GO:0031338)3.22575015
73regulation of respiratory system process (GO:0044065)3.21499803
74behavioral response to ethanol (GO:0048149)3.21321718
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20269076
76calcium ion-dependent exocytosis (GO:0017156)3.20098467
77dendritic spine morphogenesis (GO:0060997)3.18851985
78regulation of respiratory gaseous exchange (GO:0043576)3.18594193
79neuromuscular synaptic transmission (GO:0007274)3.17777303
80adult walking behavior (GO:0007628)3.16427314
81positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.16276424
82regulation of voltage-gated calcium channel activity (GO:1901385)3.14578281
83cell migration in hindbrain (GO:0021535)3.12713804
84axonal fasciculation (GO:0007413)3.12537477
85response to pheromone (GO:0019236)3.10545684
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.08280230
87long-term synaptic potentiation (GO:0060291)3.08235520
88regulation of synaptic plasticity (GO:0048167)3.07285151
89regulation of dendritic spine morphogenesis (GO:0061001)3.05924382
90positive regulation of dendritic spine development (GO:0060999)3.05215118
91axon ensheathment in central nervous system (GO:0032291)3.05004022
92central nervous system myelination (GO:0022010)3.05004022
93positive regulation of neurotransmitter transport (GO:0051590)3.04940877
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04354694
95synapse assembly (GO:0007416)3.03705056
96neuromuscular process controlling balance (GO:0050885)3.02302377
97positive regulation of potassium ion transmembrane transport (GO:1901381)3.02229909
98serotonin metabolic process (GO:0042428)3.01166612
99positive regulation of neurotransmitter secretion (GO:0001956)3.01064797
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00285311
101primary amino compound metabolic process (GO:1901160)2.98729777
102long-chain fatty acid biosynthetic process (GO:0042759)2.98197960
103positive regulation of synapse assembly (GO:0051965)2.96373211
104synaptic transmission (GO:0007268)2.96047101
105glycine transport (GO:0015816)2.95534604
106neuronal ion channel clustering (GO:0045161)2.94312824
107central nervous system projection neuron axonogenesis (GO:0021952)2.93513281
108detection of calcium ion (GO:0005513)2.93371810
109short-term memory (GO:0007614)2.92760881
110startle response (GO:0001964)2.91811056
111neuromuscular process (GO:0050905)2.90827369
112learning (GO:0007612)2.89084997
113dendrite morphogenesis (GO:0048813)2.88717496
114regulation of synaptic transmission (GO:0050804)2.87978049
115regulation of dendritic spine development (GO:0060998)2.87742213
116righting reflex (GO:0060013)2.82884228
117establishment of mitochondrion localization (GO:0051654)2.81179732
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78255444
119synaptic vesicle transport (GO:0048489)2.78032300
120establishment of synaptic vesicle localization (GO:0097480)2.78032300
121negative regulation of dendrite development (GO:2000171)2.76362782
122adult behavior (GO:0030534)2.71984225
123detection of light stimulus involved in sensory perception (GO:0050962)2.70907919
124detection of light stimulus involved in visual perception (GO:0050908)2.70907919
125central nervous system neuron axonogenesis (GO:0021955)2.70208242
126neurofilament cytoskeleton organization (GO:0060052)2.70166166
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.68800182
128cellular sodium ion homeostasis (GO:0006883)2.67458595
129cochlea development (GO:0090102)2.67201737
130regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.64720535
131neuronal action potential (GO:0019228)2.62171335
132synapse organization (GO:0050808)2.61364180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01950673
2GBX2_23144817_ChIP-Seq_PC3_Human3.90206786
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00518282
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88652738
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82988452
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.55203814
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53444227
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53444227
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48903634
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45137530
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.43287613
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42507245
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36579087
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30096370
15DROSHA_22980978_ChIP-Seq_HELA_Human2.29020211
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.27662251
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26824857
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25729994
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23569531
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.07033650
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.06210777
22TAF15_26573619_Chip-Seq_HEK293_Human2.05843124
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00275565
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95566314
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95359212
26* REST_18959480_ChIP-ChIP_MESCs_Mouse1.94821674
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92269521
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91865815
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85722476
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83375387
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.82887322
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81294587
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78240373
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.76070206
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73026308
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71642626
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68188853
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.63483142
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60980672
40P300_19829295_ChIP-Seq_ESCs_Human1.60569505
41RNF2_27304074_Chip-Seq_NSC_Mouse1.51495495
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51360697
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45722294
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42894520
45* AR_21572438_ChIP-Seq_LNCaP_Human1.42417237
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38497484
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38189701
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.36955123
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36115800
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35828051
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35297181
52STAT3_23295773_ChIP-Seq_U87_Human1.35224093
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.33824493
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30535431
55AR_25329375_ChIP-Seq_VCAP_Human1.30343568
56ZNF274_21170338_ChIP-Seq_K562_Hela1.29482645
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29350804
58TCF4_23295773_ChIP-Seq_U87_Human1.28669919
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.28642728
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28106542
61EWS_26573619_Chip-Seq_HEK293_Human1.24418912
62IGF1R_20145208_ChIP-Seq_DFB_Human1.23894662
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23670327
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21989776
65CBP_20019798_ChIP-Seq_JUKART_Human1.21989776
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.21481457
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.20029151
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.19341548
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.19115085
70* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18454078
71* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18411031
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17221171
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16179202
74FUS_26573619_Chip-Seq_HEK293_Human1.15988838
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14350145
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13623139
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12842681
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12633436
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11899362
80RUNX2_22187159_ChIP-Seq_PCA_Human1.11698232
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11318774
82* E2F1_18555785_Chip-Seq_ESCs_Mouse1.09956988
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09647281
84ER_23166858_ChIP-Seq_MCF-7_Human1.09629546
85AR_19668381_ChIP-Seq_PC3_Human1.09224660
86* TCF4_22108803_ChIP-Seq_LS180_Human1.08956782
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08267870
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08025077
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.07654111
90* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07352248
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.07272297
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07074671
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06129330
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05966998
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05966998
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05392314
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.05181717
98* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04516450
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04027178
100* SOX9_26525672_Chip-Seq_HEART_Mouse1.03797581
101KDM2B_26808549_Chip-Seq_REH_Human1.03039430
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01547294
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01159001
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.01127483
105* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00291625
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99827281
107* P53_22387025_ChIP-Seq_ESCs_Mouse0.99152089
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98512262
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98328028
110AHR_22903824_ChIP-Seq_MCF-7_Human0.98219311
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98201681
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98158321
113BCAT_22108803_ChIP-Seq_LS180_Human0.97310153
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.96635435
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.96079059
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.95449155
117JUN_21703547_ChIP-Seq_K562_Human0.95328090
118VDR_22108803_ChIP-Seq_LS180_Human0.95070536
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93829008
120* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93436515
121* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92931414
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92143524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22935484
2MP0003880_abnormal_central_pattern4.14042569
3MP0003635_abnormal_synaptic_transmissio3.81613783
4MP0009046_muscle_twitch3.76722419
5MP0004270_analgesia3.44298924
6MP0001968_abnormal_touch/_nociception3.31841139
7MP0009745_abnormal_behavioral_response3.29338533
8MP0002064_seizures3.10278485
9MP0002063_abnormal_learning/memory/cond2.96726355
10MP0002734_abnormal_mechanical_nocicepti2.95950471
11MP0002572_abnormal_emotion/affect_behav2.78947795
12MP0002736_abnormal_nociception_after2.71555837
13MP0002272_abnormal_nervous_system2.70355911
14MP0002735_abnormal_chemical_nociception2.67095402
15MP0001486_abnormal_startle_reflex2.56098954
16MP0005423_abnormal_somatic_nervous2.51208054
17MP0002822_catalepsy2.42844329
18MP0001440_abnormal_grooming_behavior2.41526755
19MP0002067_abnormal_sensory_capabilities2.30496057
20MP0002733_abnormal_thermal_nociception2.30197088
21MP0001970_abnormal_pain_threshold2.25108373
22MP0001501_abnormal_sleep_pattern2.21414126
23MP0008569_lethality_at_weaning2.09168712
24MP0002184_abnormal_innervation2.02165614
25MP0000778_abnormal_nervous_system1.90510215
26MP0003787_abnormal_imprinting1.88935280
27MP0002557_abnormal_social/conspecific_i1.87952091
28MP0006276_abnormal_autonomic_nervous1.85119249
29MP0001188_hyperpigmentation1.81040840
30MP0005386_behavior/neurological_phenoty1.79316528
31MP0004924_abnormal_behavior1.79316528
32MP0004858_abnormal_nervous_system1.65316329
33MP0003879_abnormal_hair_cell1.64792611
34MP0004142_abnormal_muscle_tone1.61664777
35MP0001905_abnormal_dopamine_level1.59308599
36MP0004811_abnormal_neuron_physiology1.54197028
37MP0005646_abnormal_pituitary_gland1.52575201
38MP0005645_abnormal_hypothalamus_physiol1.51113071
39MP0000955_abnormal_spinal_cord1.50222985
40MP0004742_abnormal_vestibular_system1.47913734
41MP0001984_abnormal_olfaction1.45017184
42MP0002066_abnormal_motor_capabilities/c1.40853940
43MP0010386_abnormal_urinary_bladder1.40552228
44MP0002882_abnormal_neuron_morphology1.38304105
45MP0004145_abnormal_muscle_electrophysio1.34272405
46MP0001529_abnormal_vocalization1.31868836
47MP0004215_abnormal_myocardial_fiber1.31552926
48MP0002837_dystrophic_cardiac_calcinosis1.28296933
49MP0005410_abnormal_fertilization1.23862818
50MP0003633_abnormal_nervous_system1.22889400
51MP0005171_absent_coat_pigmentation1.20562930
52MP0008877_abnormal_DNA_methylation1.19817879
53MP0003631_nervous_system_phenotype1.17143153
54MP0004885_abnormal_endolymph1.16921272
55MP0003136_yellow_coat_color1.16464451
56MP0002638_abnormal_pupillary_reflex1.16158243
57MP0005253_abnormal_eye_physiology1.15157597
58MP0002152_abnormal_brain_morphology1.10906463
59MP0000566_synostosis1.09886589
60MP0005187_abnormal_penis_morphology1.09651948
61MP0001502_abnormal_circadian_rhythm1.08172350
62MP0008872_abnormal_physiological_respon1.06919456
63MP0003329_amyloid_beta_deposits1.06739480
64MP0003137_abnormal_impulse_conducting1.05860478
65MP0003122_maternal_imprinting1.05516981
66MP0003632_abnormal_nervous_system1.03683343
67MP0001963_abnormal_hearing_physiology1.03446542
68MP0006292_abnormal_olfactory_placode1.03054393
69MP0006072_abnormal_retinal_apoptosis1.01550489
70MP0005409_darkened_coat_color1.01252360
71MP0002102_abnormal_ear_morphology1.00527632
72MP0009780_abnormal_chondrocyte_physiolo0.98953628
73MP0002229_neurodegeneration0.93604893
74MP0002752_abnormal_somatic_nervous0.89478900
75MP0000569_abnormal_digit_pigmentation0.86259786
76MP0004043_abnormal_pH_regulation0.85729599
77MP0001177_atelectasis0.84683365
78MP0002909_abnormal_adrenal_gland0.84564563
79MP0000920_abnormal_myelination0.83840930
80MP0003698_abnormal_male_reproductive0.83468386
81MP0005499_abnormal_olfactory_system0.82503516
82MP0005394_taste/olfaction_phenotype0.82503516
83MP0001485_abnormal_pinna_reflex0.80457149
84MP0002069_abnormal_eating/drinking_beha0.80160289
85MP0003634_abnormal_glial_cell0.79178343
86MP0008874_decreased_physiological_sensi0.78768957
87MP0005551_abnormal_eye_electrophysiolog0.77746537
88MP0000631_abnormal_neuroendocrine_gland0.76450551
89MP0005167_abnormal_blood-brain_barrier0.75417078
90MP0002751_abnormal_autonomic_nervous0.73337455
91MP0000026_abnormal_inner_ear0.71586929
92MP0004133_heterotaxia0.69930143
93MP0001986_abnormal_taste_sensitivity0.67862754
94MP0002090_abnormal_vision0.67515253
95MP0005195_abnormal_posterior_eye0.67148874
96MP0000015_abnormal_ear_pigmentation0.66970979
97MP0008260_abnormal_autophagy0.66384506
98MP0002938_white_spotting0.66277057
99MP0004147_increased_porphyrin_level0.66008177
100MP0003690_abnormal_glial_cell0.65735764
101MP0005623_abnormal_meninges_morphology0.65142149
102MP0002876_abnormal_thyroid_physiology0.64360909
103MP0003121_genomic_imprinting0.63870187
104MP0002653_abnormal_ependyma_morphology0.63644155
105MP0003861_abnormal_nervous_system0.63454575
106MP0001664_abnormal_digestion0.61598284
107MP0005535_abnormal_body_temperature0.61554020
108MP0000751_myopathy0.60908393
109MP0003195_calcinosis0.60795435
110MP0002160_abnormal_reproductive_system0.59479072
111MP0000427_abnormal_hair_cycle0.57483439
112MP0004085_abnormal_heartbeat0.57258749
113MP0001943_abnormal_respiration0.55042443
114MP0010769_abnormal_survival0.54699174
115MP0002082_postnatal_lethality0.54341884
116MP0010770_preweaning_lethality0.54341884
117MP0004484_altered_response_of0.53483318

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.37962797
2Myokymia (HP:0002411)5.99290265
3Focal seizures (HP:0007359)5.61218508
4Progressive cerebellar ataxia (HP:0002073)5.25009715
5Febrile seizures (HP:0002373)4.94419975
6Epileptic encephalopathy (HP:0200134)4.82263002
7Atonic seizures (HP:0010819)4.56370243
8Visual hallucinations (HP:0002367)4.31547808
9Gaze-evoked nystagmus (HP:0000640)4.24371637
10Action tremor (HP:0002345)4.14779081
11Broad-based gait (HP:0002136)3.89721107
12Generalized tonic-clonic seizures (HP:0002069)3.70693462
13Absence seizures (HP:0002121)3.55762347
14Dialeptic seizures (HP:0011146)3.46910141
15Absent/shortened dynein arms (HP:0200106)3.30296746
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.30296746
17Poor eye contact (HP:0000817)3.06911017
18Impaired smooth pursuit (HP:0007772)3.06865212
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94680225
20Genetic anticipation (HP:0003743)2.90134566
21Scanning speech (HP:0002168)2.89685287
22Hemiparesis (HP:0001269)2.88319682
23Dysdiadochokinesis (HP:0002075)2.87273585
24Truncal ataxia (HP:0002078)2.81907008
25Dysmetria (HP:0001310)2.79266785
26Supranuclear gaze palsy (HP:0000605)2.78465410
27Abnormality of binocular vision (HP:0011514)2.77303724
28Diplopia (HP:0000651)2.77303724
29Abnormality of ocular smooth pursuit (HP:0000617)2.76141402
30Urinary bladder sphincter dysfunction (HP:0002839)2.73327614
31Ankle clonus (HP:0011448)2.71762291
32Hyperventilation (HP:0002883)2.70446808
33Absent speech (HP:0001344)2.70315111
34Impaired vibration sensation in the lower limbs (HP:0002166)2.70286391
35Limb dystonia (HP:0002451)2.70156185
36Fetal akinesia sequence (HP:0001989)2.69147767
37Nephronophthisis (HP:0000090)2.68747584
38Abnormality of the corticospinal tract (HP:0002492)2.68635621
39Congenital stationary night blindness (HP:0007642)2.66733493
40True hermaphroditism (HP:0010459)2.60339181
41Abnormal eating behavior (HP:0100738)2.59701938
42Amblyopia (HP:0000646)2.56214189
43Pancreatic fibrosis (HP:0100732)2.55134898
44Abnormal respiratory motile cilium physiology (HP:0012261)2.54571124
45Type II lissencephaly (HP:0007260)2.52587632
46Abnormal ciliary motility (HP:0012262)2.50792298
47Dysmetric saccades (HP:0000641)2.49569936
48Pancreatic cysts (HP:0001737)2.46133937
49Chronic hepatic failure (HP:0100626)2.44246800
50Abnormal social behavior (HP:0012433)2.43065988
51Impaired social interactions (HP:0000735)2.43065988
52Postural instability (HP:0002172)2.43061639
53Depression (HP:0000716)2.41933261
54Excessive salivation (HP:0003781)2.35311537
55Drooling (HP:0002307)2.35311537
56Abnormality of midbrain morphology (HP:0002418)2.34043311
57Molar tooth sign on MRI (HP:0002419)2.34043311
58Mutism (HP:0002300)2.31911072
59Abnormal respiratory epithelium morphology (HP:0012253)2.26200205
60Abnormal respiratory motile cilium morphology (HP:0005938)2.26200205
61Hypothermia (HP:0002045)2.24925845
62Hemiplegia (HP:0002301)2.23878124
63Abnormality of the labia minora (HP:0012880)2.22291634
64Spastic gait (HP:0002064)2.21232711
65Abnormality of the renal medulla (HP:0100957)2.19019480
66Syncope (HP:0001279)2.18016811
67Anxiety (HP:0000739)2.14797046
68Prolonged QT interval (HP:0001657)2.14337792
69Gait ataxia (HP:0002066)2.13188008
70Polyphagia (HP:0002591)2.12350917
71Abnormality of saccadic eye movements (HP:0000570)2.11802991
72Epileptiform EEG discharges (HP:0011182)2.11750083
73Progressive inability to walk (HP:0002505)2.11485483
74Gait imbalance (HP:0002141)2.09415412
75Inability to walk (HP:0002540)2.08354916
76Vaginal atresia (HP:0000148)2.07954358
77Abnormality of the lower motor neuron (HP:0002366)2.06003067
78Abnormal hair whorl (HP:0010721)2.05349536
79Impaired vibratory sensation (HP:0002495)2.01476231
80Protruding tongue (HP:0010808)2.00922326
81Lissencephaly (HP:0001339)2.00553964
82Abnormality of the renal cortex (HP:0011035)1.97971520
83Stereotypic behavior (HP:0000733)1.96387019
84EEG with generalized epileptiform discharges (HP:0011198)1.96108639
85Intention tremor (HP:0002080)1.94434101
86Abnormal drinking behavior (HP:0030082)1.94422384
87Polydipsia (HP:0001959)1.94422384
88Postural tremor (HP:0002174)1.93118654
89Bradykinesia (HP:0002067)1.93025146
90Blue irides (HP:0000635)1.92174626
91Urinary urgency (HP:0000012)1.91522808
92Pachygyria (HP:0001302)1.91476655
93Limb ataxia (HP:0002070)1.90375959
94Morphological abnormality of the pyramidal tract (HP:0002062)1.88747418
95Incomplete penetrance (HP:0003829)1.87496154
96Termporal pattern (HP:0011008)1.87421589
97Insidious onset (HP:0003587)1.87421589
98Optic nerve hypoplasia (HP:0000609)1.87255898
99Medial flaring of the eyebrow (HP:0010747)1.87164126
100Nephrogenic diabetes insipidus (HP:0009806)1.87093493
101Retinal dysplasia (HP:0007973)1.86031469
102Agitation (HP:0000713)1.85472164
103Status epilepticus (HP:0002133)1.85102117
104Specific learning disability (HP:0001328)1.84638143
105Horizontal nystagmus (HP:0000666)1.84087084
106Decreased circulating renin level (HP:0003351)1.82782288
107Failure to thrive in infancy (HP:0001531)1.81522754
108Aqueductal stenosis (HP:0002410)1.81463625
109Hypsarrhythmia (HP:0002521)1.80869526
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.80232136
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.78693970
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78693970
113Oligodactyly (hands) (HP:0001180)1.78536213
114Cutaneous finger syndactyly (HP:0010554)1.77832632
115Cystic liver disease (HP:0006706)1.77152462
116Abnormality of salivation (HP:0100755)1.75551524
117Torticollis (HP:0000473)1.74927642
118Clumsiness (HP:0002312)1.72890063
119Hypoventilation (HP:0002791)1.72443448
120Lower limb muscle weakness (HP:0007340)1.71907616
121Genital tract atresia (HP:0001827)1.71783326
122Congenital primary aphakia (HP:0007707)1.71221775
123Bradycardia (HP:0001662)1.70729195
124Generalized hypopigmentation of hair (HP:0011358)1.70233053
125Akinesia (HP:0002304)1.70086168
126Amyotrophic lateral sclerosis (HP:0007354)1.69680520
127Renal cortical cysts (HP:0000803)1.69492731
128Cerebellar dysplasia (HP:0007033)1.69426186
129Obstructive sleep apnea (HP:0002870)1.68932863
130Megalencephaly (HP:0001355)1.64790816
131Attenuation of retinal blood vessels (HP:0007843)1.62354746
132Abnormal rod and cone electroretinograms (HP:0008323)1.60764964
133Spastic tetraplegia (HP:0002510)1.59300777
134Occipital encephalocele (HP:0002085)1.58827429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.01004370
2CASK3.78108029
3FRK3.55483136
4MAP3K43.31980455
5MAP2K73.31221870
6MARK12.98732458
7MAP3K92.79056473
8EPHA42.63309951
9DAPK22.60123398
10MINK12.36143144
11MAP3K122.25319093
12TNIK2.04269719
13NTRK22.03036002
14CAMKK22.01926174
15CDK192.01270687
16RIPK41.97444205
17MAP2K41.95515951
18MAPK131.88638474
19PNCK1.87918490
20WNK31.85698044
21PAK61.72032731
22PLK21.66770019
23NTRK11.66153560
24CAMKK11.65625384
25PRPF4B1.64520063
26GRK51.62779402
27MAP4K21.53118890
28DAPK11.46720419
29DYRK21.41696087
30OXSR11.36323508
31CDK51.30701671
32FGFR21.27207455
33PAK31.26887548
34PRKCG1.26863020
35ADRBK21.20978877
36SIK21.20841711
37WNK11.20667401
38BMPR21.16221138
39STK381.15562661
40SGK4941.07166748
41SGK2231.07166748
42AKT31.05391071
43ZAK1.04353707
44SIK31.03291278
45SGK21.02563032
46UHMK11.00176289
47ARAF0.98926438
48CAMK2A0.98728053
49PRKD30.97432735
50PINK10.95385166
51CSNK1G10.95323531
52CSNK1A1L0.92877906
53WNK40.92141861
54PTK2B0.91051282
55CSNK1G30.90588892
56CAMK1D0.89960847
57CAMK1G0.87576370
58KSR10.87301009
59NEK60.87012953
60GRK70.85778500
61CDK180.85051505
62NUAK10.84571833
63CAMK10.83264544
64CAMK2B0.82628217
65MUSK0.82289333
66GRK10.81273746
67CDK150.81070454
68DYRK1A0.78301129
69STK110.77669885
70PHKG10.75913727
71PHKG20.75913727
72CDK30.75205845
73ACVR1B0.74049373
74CDK140.73582321
75LATS20.71237457
76PRKCE0.70445628
77TYRO30.70054855
78EPHA30.69554780
79CDK11A0.69096388
80MAPKAPK50.69050397
81FES0.67990266
82SGK30.67850019
83KSR20.66364452
84MAP3K130.63648081
85TLK10.61122496
86SGK10.61098776
87CDC42BPA0.60126309
88LATS10.58844497
89STK390.57862541
90FGR0.57591785
91CSNK1G20.56777002
92FER0.56269378
93MAP3K60.55982728
94MKNK20.54883344
95PKN10.53076847
96PRKACA0.53022150
97ALK0.52428171
98ERBB30.52178376
99CAMK40.51792652
100CAMK2G0.51499668
101PDK30.51191888
102PDK40.51191888
103BCR0.49352091
104MARK20.49192273
105CSNK1D0.49170234
106INSRR0.47006205
107CAMK2D0.46319195
108CSNK1A10.46227307
109MAPK120.45314075
110OBSCN0.43885047
111PRKCH0.43508174
112PRKAA10.43322711
113PDK10.42779119
114STK38L0.42425659
115TNK20.42060825
116ROCK10.41775381
117YES10.41197646
118PRKG10.40592992
119ERBB20.40468151
120CCNB10.39818817
121PRKCA0.38949248
122CSNK1E0.38946042
123ADRBK10.38459577
124RET0.38251407
125BRAF0.37983891
126MAP2K60.37878717
127PDPK10.37052863
128LMTK20.36121632
129RPS6KA30.35540952
130BMPR1B0.34635585
131PRKACB0.34420595
132PRKCZ0.34267887
133FYN0.34123789
134RPS6KB10.34109137

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23814504
2Synaptic vesicle cycle_Homo sapiens_hsa047213.46846060
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90128634
4Glutamatergic synapse_Homo sapiens_hsa047242.84837936
5Circadian entrainment_Homo sapiens_hsa047132.72942717
6Morphine addiction_Homo sapiens_hsa050322.67157219
7Olfactory transduction_Homo sapiens_hsa047402.61075854
8GABAergic synapse_Homo sapiens_hsa047272.55539521
9Long-term potentiation_Homo sapiens_hsa047202.51218336
10Amphetamine addiction_Homo sapiens_hsa050312.47200153
11Taste transduction_Homo sapiens_hsa047422.37553765
12Salivary secretion_Homo sapiens_hsa049702.22729539
13Dopaminergic synapse_Homo sapiens_hsa047282.13446390
14Long-term depression_Homo sapiens_hsa047302.04802867
15Serotonergic synapse_Homo sapiens_hsa047262.03287313
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90697595
17Insulin secretion_Homo sapiens_hsa049111.89895642
18Cholinergic synapse_Homo sapiens_hsa047251.88492832
19Gastric acid secretion_Homo sapiens_hsa049711.80817025
20Collecting duct acid secretion_Homo sapiens_hsa049661.76659659
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65173387
22Calcium signaling pathway_Homo sapiens_hsa040201.63440106
23Renin secretion_Homo sapiens_hsa049241.58535105
24Cocaine addiction_Homo sapiens_hsa050301.56927486
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56119877
26Nitrogen metabolism_Homo sapiens_hsa009101.49397906
27Oxytocin signaling pathway_Homo sapiens_hsa049211.48528687
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44736940
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39205213
30Butanoate metabolism_Homo sapiens_hsa006501.38192072
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34091922
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31735519
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30026877
34GnRH signaling pathway_Homo sapiens_hsa049121.28366819
35cAMP signaling pathway_Homo sapiens_hsa040241.26035047
36Gap junction_Homo sapiens_hsa045401.20291349
37Axon guidance_Homo sapiens_hsa043601.19268490
38Dorso-ventral axis formation_Homo sapiens_hsa043201.11601320
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11242437
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04517323
41Estrogen signaling pathway_Homo sapiens_hsa049151.02208830
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02050369
43Type II diabetes mellitus_Homo sapiens_hsa049301.01033613
44Cardiac muscle contraction_Homo sapiens_hsa042601.00922068
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99112766
46ErbB signaling pathway_Homo sapiens_hsa040120.98696934
47Vibrio cholerae infection_Homo sapiens_hsa051100.97128513
48Propanoate metabolism_Homo sapiens_hsa006400.96916359
49Regulation of autophagy_Homo sapiens_hsa041400.96593916
50Linoleic acid metabolism_Homo sapiens_hsa005910.95794996
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94246728
52Melanogenesis_Homo sapiens_hsa049160.91050183
53Pancreatic secretion_Homo sapiens_hsa049720.90561987
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89775286
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.87552559
56Fatty acid biosynthesis_Homo sapiens_hsa000610.84509825
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84395983
58Oocyte meiosis_Homo sapiens_hsa041140.81391675
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81347343
60Phototransduction_Homo sapiens_hsa047440.79537839
61Vitamin B6 metabolism_Homo sapiens_hsa007500.76883557
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.76428137
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76132938
64MAPK signaling pathway_Homo sapiens_hsa040100.75116994
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69469912
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68751169
67Glioma_Homo sapiens_hsa052140.68686405
68Inositol phosphate metabolism_Homo sapiens_hsa005620.67713715
69Thyroid hormone synthesis_Homo sapiens_hsa049180.66791763
70Bile secretion_Homo sapiens_hsa049760.64163679
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64151144
72Ras signaling pathway_Homo sapiens_hsa040140.64054248
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63416714
74ABC transporters_Homo sapiens_hsa020100.62348492
75Alzheimers disease_Homo sapiens_hsa050100.62306761
76Rheumatoid arthritis_Homo sapiens_hsa053230.61829379
77Choline metabolism in cancer_Homo sapiens_hsa052310.59914502
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59596349
79Type I diabetes mellitus_Homo sapiens_hsa049400.58946040
80Dilated cardiomyopathy_Homo sapiens_hsa054140.58252112
81Oxidative phosphorylation_Homo sapiens_hsa001900.57561941
82Tryptophan metabolism_Homo sapiens_hsa003800.56804660
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56484707
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55532725
85Histidine metabolism_Homo sapiens_hsa003400.55107646
86African trypanosomiasis_Homo sapiens_hsa051430.54893782
87beta-Alanine metabolism_Homo sapiens_hsa004100.54412383
88Wnt signaling pathway_Homo sapiens_hsa043100.53003011
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.51975461
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51499277
91Alcoholism_Homo sapiens_hsa050340.51361780
92Circadian rhythm_Homo sapiens_hsa047100.50688088
93Ovarian steroidogenesis_Homo sapiens_hsa049130.50682242
94Rap1 signaling pathway_Homo sapiens_hsa040150.50640401
95Fatty acid metabolism_Homo sapiens_hsa012120.48754211
96Arginine and proline metabolism_Homo sapiens_hsa003300.48346338
97Phagosome_Homo sapiens_hsa041450.47436650
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46646711
99Selenocompound metabolism_Homo sapiens_hsa004500.46607325
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46571268
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.46415953
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45114811
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.41870929
104Chemokine signaling pathway_Homo sapiens_hsa040620.40816896
105Steroid biosynthesis_Homo sapiens_hsa001000.40357610
106Hedgehog signaling pathway_Homo sapiens_hsa043400.40289153
107Huntingtons disease_Homo sapiens_hsa050160.39253383
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38851292
109Endocytosis_Homo sapiens_hsa041440.37355462
110Mineral absorption_Homo sapiens_hsa049780.37323378
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36853079
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36156879
113Parkinsons disease_Homo sapiens_hsa050120.35524233
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34610940
115Ether lipid metabolism_Homo sapiens_hsa005650.33948490
116Hippo signaling pathway_Homo sapiens_hsa043900.33339361
117Glucagon signaling pathway_Homo sapiens_hsa049220.33279138
118Prion diseases_Homo sapiens_hsa050200.32721189
119Glycerolipid metabolism_Homo sapiens_hsa005610.32499900
120Peroxisome_Homo sapiens_hsa041460.32482072
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31369931
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.30739625
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.29366059
124VEGF signaling pathway_Homo sapiens_hsa043700.27498490
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25717962
126Melanoma_Homo sapiens_hsa052180.24363780
127Sphingolipid metabolism_Homo sapiens_hsa006000.24191387
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23020691
129Salmonella infection_Homo sapiens_hsa051320.22912979

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