GAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.62651763
2collagen fibril organization (GO:0030199)5.83571627
3metanephric mesenchyme development (GO:0072075)5.28749155
4chondrocyte proliferation (GO:0035988)5.13892075
5kidney mesenchyme development (GO:0072074)5.12552150
6bone trabecula formation (GO:0060346)5.08957977
7planar cell polarity pathway involved in neural tube closure (GO:0090179)5.07202145
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.95063607
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.74964654
10* middle ear morphogenesis (GO:0042474)4.40237577
11mesenchymal-epithelial cell signaling (GO:0060638)4.36614490
12* outer ear morphogenesis (GO:0042473)4.18102403
13endodermal cell differentiation (GO:0035987)4.17510411
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.12153996
15axon extension involved in axon guidance (GO:0048846)4.12153996
16glomerular basement membrane development (GO:0032836)4.11302935
17collagen metabolic process (GO:0032963)4.03707755
18negative regulation of chondrocyte differentiation (GO:0032331)4.02394532
19collagen catabolic process (GO:0030574)3.94271330
20dermatan sulfate biosynthetic process (GO:0030208)3.82266564
21multicellular organismal macromolecule metabolic process (GO:0044259)3.81126353
22paraxial mesoderm development (GO:0048339)3.80570167
23sequestering of extracellular ligand from receptor (GO:0035581)3.80287669
24skin morphogenesis (GO:0043589)3.79092565
25regulation of heart morphogenesis (GO:2000826)3.69085908
26* embryonic cranial skeleton morphogenesis (GO:0048701)3.65756462
27multicellular organismal catabolic process (GO:0044243)3.64956482
28dermatan sulfate metabolic process (GO:0030205)3.64429936
29embryonic skeletal joint morphogenesis (GO:0060272)3.62020478
30hemidesmosome assembly (GO:0031581)3.61318116
31multicellular organismal metabolic process (GO:0044236)3.60254114
32lateral sprouting from an epithelium (GO:0060601)3.58063034
33cell proliferation involved in metanephros development (GO:0072203)3.54313009
34muscle cell fate commitment (GO:0042693)3.52517972
35mesenchyme morphogenesis (GO:0072132)3.47919091
36negative regulation of cartilage development (GO:0061037)3.46854317
37tooth mineralization (GO:0034505)3.46678294
38fibril organization (GO:0097435)3.46475393
39Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.45935564
40cochlea morphogenesis (GO:0090103)3.43825333
41mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.42546942
42positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.41334540
43craniofacial suture morphogenesis (GO:0097094)3.40139529
44extracellular matrix disassembly (GO:0022617)3.39694713
45basement membrane organization (GO:0071711)3.38990398
46hippo signaling (GO:0035329)3.37922760
47keratan sulfate catabolic process (GO:0042340)3.37150599
48cell migration involved in heart development (GO:0060973)3.36309833
49* positive regulation of mesenchymal cell proliferation (GO:0002053)3.33737674
50negative regulation of catenin import into nucleus (GO:0035414)3.33639175
51non-canonical Wnt signaling pathway (GO:0035567)3.33351881
52regulation of establishment of planar polarity (GO:0090175)3.33324333
53pattern specification involved in kidney development (GO:0061004)3.29931068
54organ induction (GO:0001759)3.29765772
55vascular endothelial growth factor signaling pathway (GO:0038084)3.25395169
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.20571299
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.18286493
58establishment of planar polarity (GO:0001736)3.14692637
59establishment of tissue polarity (GO:0007164)3.14692637
60regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.13730240
61cartilage morphogenesis (GO:0060536)3.13338839
62regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.13285079
63mesenchymal cell proliferation (GO:0010463)3.12553940
64camera-type eye morphogenesis (GO:0048593)3.12075283
65positive regulation of extracellular matrix organization (GO:1903055)3.11678134
66* regulation of mesenchymal cell proliferation (GO:0010464)3.08038201
67cell proliferation involved in kidney development (GO:0072111)3.06209347
68positive regulation of epithelial to mesenchymal transition (GO:0010718)3.06144104
69insulin-like growth factor receptor signaling pathway (GO:0048009)3.06110967
70negative regulation of embryonic development (GO:0045992)3.05738012
71mesenchyme development (GO:0060485)3.04478185
72regulation of gastrulation (GO:0010470)3.02748841
73embryonic forelimb morphogenesis (GO:0035115)3.01383697
74glomerular visceral epithelial cell development (GO:0072015)3.00274695
75regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.94072521
76forelimb morphogenesis (GO:0035136)2.92621410
77positive regulation of fatty acid beta-oxidation (GO:0032000)2.92446129
78extracellular fibril organization (GO:0043206)2.91806088
79positive regulation of gastrulation (GO:2000543)2.91642795
80negative regulation of fatty acid transport (GO:2000192)2.90934970
81positive regulation of chondrocyte differentiation (GO:0032332)2.89910545
82endocardial cushion morphogenesis (GO:0003203)2.88504647
83regulation of chondrocyte differentiation (GO:0032330)2.88414957
84regulation of organ formation (GO:0003156)2.87881259
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.87322897
86glial cell migration (GO:0008347)2.87277499
87face morphogenesis (GO:0060325)2.86690362
88cellular response to vitamin (GO:0071295)2.83540729
89positive regulation of endothelial cell apoptotic process (GO:2000353)2.83288096
90cardiac myofibril assembly (GO:0055003)2.82447783
91cardiac muscle cell proliferation (GO:0060038)2.82089115
92chondrocyte development (GO:0002063)2.82064575
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.80684421
94bone morphogenesis (GO:0060349)2.80662222
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80367734
96cell migration involved in sprouting angiogenesis (GO:0002042)2.79351929
97lymph vessel development (GO:0001945)2.78379381
98extracellular matrix assembly (GO:0085029)2.78363100
99proximal/distal pattern formation (GO:0009954)2.77770354
100mesenchymal cell differentiation involved in renal system development (GO:2001012)2.77652665
101mesenchymal cell differentiation involved in kidney development (GO:0072161)2.77652665
102smooth muscle tissue development (GO:0048745)2.76538661
103convergent extension (GO:0060026)2.74943320
104plasma membrane repair (GO:0001778)2.74921566
105peripheral nervous system axon ensheathment (GO:0032292)2.73891493
106myelination in peripheral nervous system (GO:0022011)2.73891493
107mesonephric tubule development (GO:0072164)2.73479317
108anatomical structure regression (GO:0060033)2.73148385
109endothelial cell morphogenesis (GO:0001886)2.72782663
110negative regulation of leukocyte chemotaxis (GO:0002689)2.72368178
111glomerulus development (GO:0032835)2.72278362
112regulation of cartilage development (GO:0061035)2.72225021
113regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.72213271
114neural crest cell development (GO:0014032)2.71146641
115trabecula formation (GO:0060343)2.70783260
116positive regulation of cartilage development (GO:0061036)2.70531470
117midgut development (GO:0007494)2.70419377
118notochord development (GO:0030903)2.69883523
119developmental induction (GO:0031128)2.69784058
120negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.69724383
121* embryonic skeletal system morphogenesis (GO:0048704)2.67199268
122extracellular matrix organization (GO:0030198)2.66378995
123mesonephric epithelium development (GO:0072163)2.66113325
124axis elongation (GO:0003401)2.64147171
125extracellular structure organization (GO:0043062)2.63335518
126* eye morphogenesis (GO:0048592)2.60199537
127tongue development (GO:0043586)2.59988638
128cell-cell signaling involved in cell fate commitment (GO:0045168)2.59357212
129lung-associated mesenchyme development (GO:0060484)2.58780871
130blood vessel maturation (GO:0001955)2.54834521
131artery morphogenesis (GO:0048844)2.53229728
132embryonic limb morphogenesis (GO:0030326)2.52123814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.46732449
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.07898615
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.99083712
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52596724
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.23328975
6CLOCK_20551151_ChIP-Seq_293T_Human2.93883290
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.46411788
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.43219486
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.43114274
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.36447573
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35727879
12* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.35721614
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34661045
14* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.33088083
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31134417
16* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.30914691
17TP53_20018659_ChIP-ChIP_R1E_Mouse2.27767027
18SOX9_24532713_ChIP-Seq_HFSC_Mouse2.07309762
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05217245
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04226427
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04226427
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02458866
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01376853
24EZH2_22144423_ChIP-Seq_EOC_Human1.98390334
25* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.98088414
26CJUN_26792858_Chip-Seq_BT549_Human1.95856812
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83163907
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.82823858
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.80702168
30BRD4_25478319_ChIP-Seq_HGPS_Human1.79808151
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79623734
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.76372382
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.75862482
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70084342
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62934747
36* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61901639
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.61041522
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59682197
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59317623
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57575842
41* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53917763
42* ISL1_27105846_Chip-Seq_CPCs_Mouse1.50695441
43* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50098363
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48203648
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45423933
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.45367486
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.42062082
48* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41883152
49* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41883152
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.41866659
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41721292
52* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.41546029
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.39895917
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39344909
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35926694
56* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35641109
57TP53_18474530_ChIP-ChIP_U2OS_Human1.34081039
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32793105
59* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32239156
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31940578
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31940578
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31421341
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.30680720
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29900738
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29887117
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29819443
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29580737
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28292142
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26960597
70* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25513917
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24735861
72* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23710891
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23141906
74* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19478467
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19422508
76AR_21572438_ChIP-Seq_LNCaP_Human1.19082658
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16783219
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16439018
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.16245831
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.15403025
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.15403025
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14556609
83TP53_16413492_ChIP-PET_HCT116_Human1.14430745
84* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14370888
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13964835
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12447057
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11657929
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11652654
89RACK7_27058665_Chip-Seq_MCF-7_Human1.10974648
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10840426
91* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10620170
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09563045
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.08778817
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08327761
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08041585
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08007649
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08007649
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08007649
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06911226
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06836826
101KDM2B_26808549_Chip-Seq_K562_Human1.06610031
102* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06181398
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.05154652
104* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04737109
105SOX2_20726797_ChIP-Seq_SW620_Human1.04464796
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04455618
107* SA1_22415368_ChIP-Seq_MEFs_Mouse1.04367988
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03279477
109* EZH2_27294783_Chip-Seq_ESCs_Mouse1.02888460
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02628901
111P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02301676
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00531584
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00515511
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00341172
115TP53_23651856_ChIP-Seq_MEFs_Mouse0.98846452
116* KDM2B_26808549_Chip-Seq_JURKAT_Human0.98314706
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98004775
118* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96935332
119LXR_22292898_ChIP-Seq_THP-1_Human0.91033138
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89057555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.79912827
2MP0005503_abnormal_tendon_morphology5.22658409
3MP0005275_abnormal_skin_tensile4.58562866
4MP0003705_abnormal_hypodermis_morpholog3.85900839
5MP0010030_abnormal_orbit_morphology3.10724461
6MP0003279_aneurysm2.71449691
7MP0005623_abnormal_meninges_morphology2.67335679
8MP0004272_abnormal_basement_membrane2.56651265
9MP0001958_emphysema2.46312899
10MP0005508_abnormal_skeleton_morphology2.46286382
11MP0009250_abnormal_appendicular_skeleto2.38862986
12MP0002249_abnormal_larynx_morphology2.34657045
13MP0009384_cardiac_valve_regurgitation2.24932195
14MP0002060_abnormal_skin_morphology2.23250539
15MP0003385_abnormal_body_wall2.13958939
16MP0009053_abnormal_anal_canal2.13688102
17MP0003942_abnormal_urinary_system2.09678217
18MP0002282_abnormal_trachea_morphology2.00896070
19MP0002108_abnormal_muscle_morphology1.94276780
20MP0000534_abnormal_ureter_morphology1.86378049
21MP0006054_spinal_hemorrhage1.84790528
22MP0000537_abnormal_urethra_morphology1.82629210
23* MP0000049_abnormal_middle_ear1.80332411
24MP0003941_abnormal_skin_development1.69639027
25MP0005257_abnormal_intraocular_pressure1.68688511
26MP0002932_abnormal_joint_morphology1.66716639
27* MP0000428_abnormal_craniofacial_morphol1.63537934
28MP0000733_abnormal_muscle_development1.61407792
29MP0001299_abnormal_eye_distance/1.58788746
30MP0003755_abnormal_palate_morphology1.54915220
31MP0000762_abnormal_tongue_morphology1.52367735
32MP0005367_renal/urinary_system_phenotyp1.51723318
33MP0000516_abnormal_urinary_system1.51723318
34MP0004858_abnormal_nervous_system1.50774439
35MP0005023_abnormal_wound_healing1.47694044
36MP0002896_abnormal_bone_mineralization1.45630457
37MP0001849_ear_inflammation1.42505294
38* MP0000163_abnormal_cartilage_morphology1.41033153
39MP0003283_abnormal_digestive_organ1.40632338
40MP0009379_abnormal_foot_pigmentation1.34131005
41MP0001346_abnormal_lacrimal_gland1.33247147
42MP0003115_abnormal_respiratory_system1.33121240
43* MP0002115_abnormal_skeleton_extremities1.32886237
44* MP0003937_abnormal_limbs/digits/tail_de1.32324710
45MP0000579_abnormal_nail_morphology1.26108440
46MP0003566_abnormal_cell_adhesion1.25599838
47MP0005076_abnormal_cell_differentiation1.23637869
48MP0005171_absent_coat_pigmentation1.23397226
49* MP0002233_abnormal_nose_morphology1.22578144
50MP0003935_abnormal_craniofacial_develop1.21959538
51MP0004134_abnormal_chest_morphology1.21173327
52MP0010368_abnormal_lymphatic_system1.20675215
53* MP0002116_abnormal_craniofacial_bone1.18592773
54MP0003091_abnormal_cell_migration1.16636781
55MP0002295_abnormal_pulmonary_circulatio1.15205297
56MP0001243_abnormal_dermal_layer1.14848392
57MP0000566_synostosis1.14051909
58MP0000432_abnormal_head_morphology1.12483072
59MP0005390_skeleton_phenotype1.11790817
60* MP0002109_abnormal_limb_morphology1.09400941
61MP0000767_abnormal_smooth_muscle1.08910143
62MP0002234_abnormal_pharynx_morphology1.06866493
63MP0002113_abnormal_skeleton_development1.05298441
64MP0000462_abnormal_digestive_system1.02675348
65MP0000467_abnormal_esophagus_morphology1.01950163
66MP0002111_abnormal_tail_morphology1.00868352
67MP0000759_abnormal_skeletal_muscle1.00355215
68MP0002938_white_spotting0.97565199
69MP0001348_abnormal_lacrimal_gland0.96301517
70MP0005595_abnormal_vascular_smooth0.94969598
71MP0002177_abnormal_outer_ear0.92180216
72MP0001270_distended_abdomen0.90554265
73MP0000751_myopathy0.89633428
74MP0002089_abnormal_postnatal_growth/wei0.89217191
75* MP0002114_abnormal_axial_skeleton0.86192432
76MP0010352_gastrointestinal_tract_polyps0.84157150
77MP0005369_muscle_phenotype0.83421317
78MP0002168_other_aberrant_phenotype0.83062037
79MP0003938_abnormal_ear_development0.82645368
80MP0000678_abnormal_parathyroid_gland0.81763786
81MP0002933_joint_inflammation0.80173759
82MP0005248_abnormal_Harderian_gland0.79049788
83MP0009780_abnormal_chondrocyte_physiolo0.78464320
84* MP0001340_abnormal_eyelid_morphology0.77912585
85MP0009278_abnormal_bone_marrow0.76533969
86MP0001879_abnormal_lymphatic_vessel0.75867224
87MP0003122_maternal_imprinting0.75311653
88* MP0002697_abnormal_eye_size0.74751782
89MP0002098_abnormal_vibrissa_morphology0.74577663
90MP0008789_abnormal_olfactory_epithelium0.74427042
91MP0010771_integument_phenotype0.74040794
92MP0004087_abnormal_muscle_fiber0.73783056
93MP0001542_abnormal_bone_strength0.73350275
94MP0003567_abnormal_fetal_cardiomyocyte0.72814537
95MP0006292_abnormal_olfactory_placode0.72769609
96MP0006138_congestive_heart_failure0.71809807
97MP0001293_anophthalmia0.71686841
98MP0002254_reproductive_system_inflammat0.71367826
99MP0002796_impaired_skin_barrier0.70640014
100MP0002128_abnormal_blood_circulation0.69182015
101* MP0005193_abnormal_anterior_eye0.67932517
102* MP0002092_abnormal_eye_morphology0.67354216
103MP0001614_abnormal_blood_vessel0.66283959
104MP0010234_abnormal_vibrissa_follicle0.65942300
105* MP0001286_abnormal_eye_development0.64685999
106* MP0002925_abnormal_cardiovascular_devel0.64311538
107MP0000377_abnormal_hair_follicle0.64307641
108MP0002133_abnormal_respiratory_system0.63607291
109MP0005388_respiratory_system_phenotype0.63607291
110MP0003453_abnormal_keratinocyte_physiol0.63536372
111* MP0005197_abnormal_uvea_morphology0.62817274
112MP0001175_abnormal_lung_morphology0.62325613
113MP0000778_abnormal_nervous_system0.61123377
114MP0004233_abnormal_muscle_weight0.60925810
115MP0000613_abnormal_salivary_gland0.60452765
116MP0000013_abnormal_adipose_tissue0.60442302
117MP0000749_muscle_degeneration0.59952607
118MP0001661_extended_life_span0.59441014
119MP0000750_abnormal_muscle_regeneration0.59402842
120MP0000003_abnormal_adipose_tissue0.59299702
121MP0001177_atelectasis0.56059809

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.15638976
2Premature rupture of membranes (HP:0001788)6.54439812
3Ankle contracture (HP:0006466)5.59839913
4Shallow orbits (HP:0000586)5.03573837
5Broad metatarsal (HP:0001783)4.63969370
6Atrophic scars (HP:0001075)4.28630284
7Follicular hyperkeratosis (HP:0007502)4.22841212
8Aortic dissection (HP:0002647)4.05165139
9Type 1 muscle fiber predominance (HP:0003803)3.90164348
10Cervical subluxation (HP:0003308)3.83976494
11Neonatal short-limb short stature (HP:0008921)3.82888577
12Soft skin (HP:0000977)3.77261806
13Bladder diverticulum (HP:0000015)3.62332498
14Fragile skin (HP:0001030)3.46088431
15Abnormality of dentin (HP:0010299)3.43799131
16Cerebral aneurysm (HP:0004944)3.21326391
17Spinal rigidity (HP:0003306)3.16396617
18Peritonitis (HP:0002586)3.08994831
19Dilatation of the ascending aorta (HP:0005111)3.01021468
20Slender build (HP:0001533)3.00478220
21Aortic aneurysm (HP:0004942)2.97867113
22Coronal craniosynostosis (HP:0004440)2.96666042
23Blue sclerae (HP:0000592)2.89430016
24Mitral valve prolapse (HP:0001634)2.87380575
25Increased connective tissue (HP:0009025)2.81831909
26Genu recurvatum (HP:0002816)2.74572479
27Biconcave vertebral bodies (HP:0004586)2.74183998
28Calcaneovalgus deformity (HP:0001848)2.71571218
29Short 4th metacarpal (HP:0010044)2.67710169
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67710169
31Abnormality of the phalanges of the hallux (HP:0010057)2.65104558
32Wrist flexion contracture (HP:0001239)2.62126919
33Wormian bones (HP:0002645)2.58787886
34Elbow flexion contracture (HP:0002987)2.58640537
35Vertebral compression fractures (HP:0002953)2.58501886
36Deviation of the hallux (HP:0010051)2.58240895
37Morphological abnormality of the middle ear (HP:0008609)2.55571888
38Mildly elevated creatine phosphokinase (HP:0008180)2.55101247
39Deformed tarsal bones (HP:0008119)2.52621578
40Hyperextensible skin (HP:0000974)2.49078517
41Increased variability in muscle fiber diameter (HP:0003557)2.43656438
42Thin ribs (HP:0000883)2.42181364
43Wide anterior fontanel (HP:0000260)2.39210923
44Abnormality of the 4th metacarpal (HP:0010012)2.38676072
45Hallux valgus (HP:0001822)2.36777632
46Short middle phalanx of the 5th finger (HP:0004220)2.36662551
47Bowel diverticulosis (HP:0005222)2.36161872
48Round ear (HP:0100830)2.34432866
49Bell-shaped thorax (HP:0001591)2.34404690
50Vascular tortuosity (HP:0004948)2.29956153
51Joint laxity (HP:0001388)2.27649578
52Partial duplication of the phalanx of hand (HP:0009999)2.27398431
53Syringomyelia (HP:0003396)2.27366164
54Spinal cord lesions (HP:0100561)2.27366164
55Mild short stature (HP:0003502)2.26459251
56Hypoplasia of the iris (HP:0007676)2.26132022
57Aortic regurgitation (HP:0001659)2.23165017
58Abnormality of the calcaneus (HP:0008364)2.18265782
59Turricephaly (HP:0000262)2.17840800
60Overgrowth (HP:0001548)2.16106133
61Knee flexion contracture (HP:0006380)2.12850719
62Buphthalmos (HP:0000557)2.11275183
63Tarsal synostosis (HP:0008368)2.10077444
64Camptodactyly of toe (HP:0001836)2.09816894
65Abnormal delivery (HP:0001787)2.08023296
66Mesomelia (HP:0003027)2.06813415
67Broad toe (HP:0001837)2.06665724
68Broad long bones (HP:0005622)2.06308809
69Natal tooth (HP:0000695)2.06030618
70Abnormality of skeletal muscle fiber size (HP:0012084)2.06017584
71Mitral regurgitation (HP:0001653)2.05159921
72Thin bony cortex (HP:0002753)2.05075867
73Broad ribs (HP:0000885)2.04111126
74Renal duplication (HP:0000075)2.02879817
75Abnormality of the distal phalanges of the toes (HP:0010182)2.01907307
76Cutaneous syndactyly (HP:0012725)2.00143299
77Delayed cranial suture closure (HP:0000270)1.99932706
78Abnormality of the ischium (HP:0003174)1.98974123
79Limited hip movement (HP:0008800)1.98347949
80Breech presentation (HP:0001623)1.98009336
81Ulnar bowing (HP:0003031)1.97376763
82Abnormality of the acetabulum (HP:0003170)1.95796452
83Short hallux (HP:0010109)1.95123205
84Bronchomalacia (HP:0002780)1.94550408
85Down-sloping shoulders (HP:0200021)1.94046920
86Ulnar deviation of the wrist (HP:0003049)1.93212498
87Absent frontal sinuses (HP:0002688)1.92799012
88Broad hallux (HP:0010055)1.90991574
89Asymmetry of the thorax (HP:0001555)1.90970278
90Synostosis involving bones of the feet (HP:0009140)1.89576821
91Synostosis involving bones of the lower limbs (HP:0009138)1.89576821
92Abnormality of the middle phalanges of the toes (HP:0010183)1.89538107
93Vitreoretinal degeneration (HP:0000655)1.89375552
94Aplasia involving bones of the upper limbs (HP:0009823)1.88345054
95Aplasia of the phalanges of the hand (HP:0009802)1.88345054
96Aplasia involving bones of the extremities (HP:0009825)1.88345054
97Hypoplastic ischia (HP:0003175)1.87853242
98Mesangial abnormality (HP:0001966)1.87141489
99Arterial tortuosity (HP:0005116)1.87114790
100Hip contracture (HP:0003273)1.86952378
101Infantile muscular hypotonia (HP:0008947)1.86941554
102Disproportionate tall stature (HP:0001519)1.86717629
103Protruding ear (HP:0000411)1.86515157
104Aneurysm (HP:0002617)1.85898059
105Pulmonary artery stenosis (HP:0004415)1.85207848
106Tibial bowing (HP:0002982)1.84321117
107Osteoarthritis (HP:0002758)1.84189942
108Ectopia lentis (HP:0001083)1.83987386
109Broad finger (HP:0001500)1.82700799
110Bowed forearm bones (HP:0003956)1.82548758
111Bowing of the arm (HP:0006488)1.82548758
112Short 5th finger (HP:0009237)1.82381439
113Cutaneous finger syndactyly (HP:0010554)1.82143879
114Synostosis involving the elbow (HP:0003938)1.82123358
115Humeroradial synostosis (HP:0003041)1.82123358
116Scapular winging (HP:0003691)1.81882753
117Osteolytic defects of the hand bones (HP:0009699)1.81601696
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.81601696
119Broad phalanges of the hand (HP:0009768)1.81415527
120Alopecia of scalp (HP:0002293)1.81226896
121Short nail (HP:0001799)1.80848258
122Inguinal hernia (HP:0000023)1.80739409
123Flat cornea (HP:0007720)1.80503983
124Femoral bowing (HP:0002980)1.80452261
125Preaxial foot polydactyly (HP:0001841)1.78832432
126Broad thumb (HP:0011304)1.77592669
127Venous insufficiency (HP:0005293)1.76017220
128Partial duplication of thumb phalanx (HP:0009944)1.75885968
129Generalized amyotrophy (HP:0003700)1.75315282
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.75262636
131Narrow nasal bridge (HP:0000446)1.74457926
132Advanced eruption of teeth (HP:0006288)1.74366163
133Broad phalanx (HP:0006009)1.70286313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.45247341
2TRIB34.19653459
3EPHB23.86342117
4PDGFRA3.73371410
5LATS13.62717992
6SIK13.38795543
7LATS23.35490435
8TTN3.02896669
9PKN22.61767968
10ERN12.19080013
11PTK61.88757614
12PAK21.86829217
13RIPK11.83666496
14MAP3K101.72878841
15FGFR21.71738283
16MAPK71.65687454
17FER1.61972623
18MST1R1.58882763
19EEF2K1.57575369
20BMX1.51624599
21STK31.46831786
22AKT31.45553635
23EPHA31.41309370
24MAP3K61.38858073
25FGFR11.37824829
26MET1.29075528
27ILK1.28853909
28PAK41.27256367
29TGFBR21.23053690
30PDGFRB1.22480990
31LRRK21.21665722
32PIK3CG1.20123760
33STK38L1.18362228
34TRPM71.15703520
35ICK1.15302763
36NLK1.12856199
37DMPK1.12499236
38PTK21.12157159
39BRSK21.10669914
40FGFR41.10490746
41ROCK11.07874533
42KIT1.04897228
43LMTK21.01887906
44MTOR1.00812420
45NEK91.00491479
46STK240.98954495
47TGFBR10.96545787
48SMG10.94903991
49PAK30.85786211
50MKNK10.84562829
51ROCK20.83153452
52PRKD20.81559926
53MARK20.79704147
54EPHB10.78750916
55RPS6KA40.77108878
56CDK60.75114915
57FGFR30.74131204
58FRK0.74068126
59ERBB30.72985538
60BRSK10.70871367
61CAMK1D0.70107053
62MAPK150.69829416
63LIMK10.68377085
64NUAK10.67461155
65MKNK20.66343205
66MOS0.66016937
67BRD40.63322795
68DYRK1B0.62814403
69TIE10.62735283
70PRKD30.61927198
71WNK10.61718888
72PRKD10.60201465
73CDK120.59548293
74MUSK0.58111618
75ERBB20.55527678
76MYLK0.55498037
77PRKCH0.55017714
78HIPK20.54080590
79MELK0.53618463
80TYRO30.52851485
81MAPK120.52551568
82PTK2B0.51933744
83CDK80.50376457
84TLK10.50370439
85MAP2K10.49733270
86MAPKAPK50.48488253
87MAP3K30.47516075
88ERBB40.47144065
89MARK10.44972609
90PIK3CA0.42768204
91PLK20.42542899
92GSK3A0.42263587
93STK380.41791545
94MAP2K20.41040986
95SRC0.40800020
96CAMK1G0.40599597
97MAP3K70.39921109
98OBSCN0.39656783
99ABL20.39226557
100ADRBK10.39107218
101INSR0.38940211
102GRK50.38440414
103CDK70.38339372
104RPS6KL10.37797036
105RPS6KC10.37797036
106CAMK2G0.37515986
107SGK2230.37374626
108SGK4940.37374626
109CHUK0.36245467
110NTRK10.36143838
111RET0.35622418
112MAPK10.34039743
113RPS6KA20.33464817
114RPS6KB20.33190884
115WEE10.32492567
116PAK60.32353528
117DYRK20.32152023
118RPS6KA10.30941513
119FLT30.30815066
120RPS6KA60.29865450
121MAPK40.28485479
122PAK10.28333413
123CDC42BPA0.28031587
124MAPKAPK20.27553656
125CLK10.27545413
126DAPK30.27339510
127AKT20.27114294
128JAK10.26402462
129TESK10.26165890
130PHKG10.25345885
131PHKG20.25345885

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.49648292
2Basal cell carcinoma_Homo sapiens_hsa052173.55528309
3Protein digestion and absorption_Homo sapiens_hsa049743.02613406
4Focal adhesion_Homo sapiens_hsa045102.94110935
5Proteoglycans in cancer_Homo sapiens_hsa052052.56514544
6Hippo signaling pathway_Homo sapiens_hsa043902.51927408
7Adherens junction_Homo sapiens_hsa045202.27155714
8Amoebiasis_Homo sapiens_hsa051462.22741689
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.20897718
10TGF-beta signaling pathway_Homo sapiens_hsa043502.18635746
11Bladder cancer_Homo sapiens_hsa052192.18571695
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17039818
13Small cell lung cancer_Homo sapiens_hsa052222.13947643
14* Hedgehog signaling pathway_Homo sapiens_hsa043402.05201491
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.01089665
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.00479066
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99213212
18Melanoma_Homo sapiens_hsa052181.88057648
19MicroRNAs in cancer_Homo sapiens_hsa052061.86479551
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.63033171
21Chronic myeloid leukemia_Homo sapiens_hsa052201.61360124
22Wnt signaling pathway_Homo sapiens_hsa043101.59691591
23Dilated cardiomyopathy_Homo sapiens_hsa054141.56129958
24Notch signaling pathway_Homo sapiens_hsa043301.54387282
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53248216
26Prostate cancer_Homo sapiens_hsa052151.46919500
27Pathways in cancer_Homo sapiens_hsa052001.42740580
28Axon guidance_Homo sapiens_hsa043601.41852874
29Melanogenesis_Homo sapiens_hsa049161.40326703
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35508069
31Malaria_Homo sapiens_hsa051441.33019356
32Glioma_Homo sapiens_hsa052141.31178868
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.15618326
34Tight junction_Homo sapiens_hsa045301.14077416
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.10805112
36HTLV-I infection_Homo sapiens_hsa051661.07448775
37Lysine degradation_Homo sapiens_hsa003101.04566918
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03554651
39Endometrial cancer_Homo sapiens_hsa052131.01117225
40Pancreatic cancer_Homo sapiens_hsa052120.99161656
41Sulfur relay system_Homo sapiens_hsa041220.99122061
42Rap1 signaling pathway_Homo sapiens_hsa040150.96818941
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96591246
44Viral myocarditis_Homo sapiens_hsa054160.92780702
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92350264
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90792769
47Choline metabolism in cancer_Homo sapiens_hsa052310.82650689
48Prion diseases_Homo sapiens_hsa050200.80895705
49Colorectal cancer_Homo sapiens_hsa052100.80608878
50p53 signaling pathway_Homo sapiens_hsa041150.80095845
51Insulin resistance_Homo sapiens_hsa049310.77738289
52Dorso-ventral axis formation_Homo sapiens_hsa043200.77659523
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.77168593
54Toxoplasmosis_Homo sapiens_hsa051450.73502056
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73131260
56mTOR signaling pathway_Homo sapiens_hsa041500.71510300
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.71076630
58Estrogen signaling pathway_Homo sapiens_hsa049150.70894445
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70379961
60PPAR signaling pathway_Homo sapiens_hsa033200.69080707
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68255197
62Circadian rhythm_Homo sapiens_hsa047100.68221438
63TNF signaling pathway_Homo sapiens_hsa046680.66820949
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65236744
65Renal cell carcinoma_Homo sapiens_hsa052110.65165546
66Renin secretion_Homo sapiens_hsa049240.64507525
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63919253
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62327483
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61392717
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61084762
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60921946
72Oxytocin signaling pathway_Homo sapiens_hsa049210.60487684
73Fatty acid degradation_Homo sapiens_hsa000710.59614541
74Renin-angiotensin system_Homo sapiens_hsa046140.59279184
75Caffeine metabolism_Homo sapiens_hsa002320.59269691
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58067318
77Chemical carcinogenesis_Homo sapiens_hsa052040.57403771
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56932891
79Thyroid cancer_Homo sapiens_hsa052160.56706738
80MAPK signaling pathway_Homo sapiens_hsa040100.56424399
81AMPK signaling pathway_Homo sapiens_hsa041520.56072825
82cAMP signaling pathway_Homo sapiens_hsa040240.55112715
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54549951
84Non-small cell lung cancer_Homo sapiens_hsa052230.53756075
85Insulin signaling pathway_Homo sapiens_hsa049100.51477801
86Fatty acid metabolism_Homo sapiens_hsa012120.51448811
87FoxO signaling pathway_Homo sapiens_hsa040680.51058676
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.50662840
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.49109745
90Platelet activation_Homo sapiens_hsa046110.48294950
91Ras signaling pathway_Homo sapiens_hsa040140.46481094
92Ovarian steroidogenesis_Homo sapiens_hsa049130.45863607
93Ribosome_Homo sapiens_hsa030100.44946790
94Gap junction_Homo sapiens_hsa045400.43755890
95Cell cycle_Homo sapiens_hsa041100.43205608
96HIF-1 signaling pathway_Homo sapiens_hsa040660.42836561
97Calcium signaling pathway_Homo sapiens_hsa040200.41574356
98GnRH signaling pathway_Homo sapiens_hsa049120.41471299
99Cocaine addiction_Homo sapiens_hsa050300.38997950
100Retinol metabolism_Homo sapiens_hsa008300.38276745
101Hepatitis B_Homo sapiens_hsa051610.36562541
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.35451478
103Acute myeloid leukemia_Homo sapiens_hsa052210.34257123
104ErbB signaling pathway_Homo sapiens_hsa040120.32733707
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.30326258
106Viral carcinogenesis_Homo sapiens_hsa052030.29988703
107Glucagon signaling pathway_Homo sapiens_hsa049220.29441548
108VEGF signaling pathway_Homo sapiens_hsa043700.29085219
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.28969985
110Sulfur metabolism_Homo sapiens_hsa009200.28639725
111Prolactin signaling pathway_Homo sapiens_hsa049170.28250677
112Thyroid hormone synthesis_Homo sapiens_hsa049180.27162739
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27109496
114Complement and coagulation cascades_Homo sapiens_hsa046100.27044110
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27009697
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25762973
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25442409
118Gastric acid secretion_Homo sapiens_hsa049710.23818609
119Endocytosis_Homo sapiens_hsa041440.22381209
120Alcoholism_Homo sapiens_hsa050340.21399540
121Circadian entrainment_Homo sapiens_hsa047130.20133074
122Cholinergic synapse_Homo sapiens_hsa047250.19763725

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