GAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.36895649
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.36895649
3L-phenylalanine metabolic process (GO:0006558)7.14321211
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.14321211
5aromatic amino acid family catabolic process (GO:0009074)6.74735693
6glyoxylate metabolic process (GO:0046487)6.62201806
7urate metabolic process (GO:0046415)6.54892580
8drug transmembrane transport (GO:0006855)6.43849235
9lysine catabolic process (GO:0006554)6.42202631
10lysine metabolic process (GO:0006553)6.42202631
11tryptophan catabolic process (GO:0006569)6.14664257
12indole-containing compound catabolic process (GO:0042436)6.14664257
13indolalkylamine catabolic process (GO:0046218)6.14664257
14cysteine metabolic process (GO:0006534)6.10024964
15tryptophan metabolic process (GO:0006568)5.80357023
16kynurenine metabolic process (GO:0070189)5.50473778
17homocysteine metabolic process (GO:0050667)5.42759897
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.35783397
19bile acid biosynthetic process (GO:0006699)5.31347892
20drug catabolic process (GO:0042737)5.23387719
21drug transport (GO:0015893)5.22870276
22water-soluble vitamin biosynthetic process (GO:0042364)5.22312687
23serine family amino acid catabolic process (GO:0009071)5.18704551
24sulfur amino acid catabolic process (GO:0000098)5.04088932
25aromatic amino acid family metabolic process (GO:0009072)4.90815726
26exogenous drug catabolic process (GO:0042738)4.87321587
27amino-acid betaine metabolic process (GO:0006577)4.80087937
28alpha-linolenic acid metabolic process (GO:0036109)4.66448516
29cellular modified amino acid catabolic process (GO:0042219)4.64992894
30alpha-amino acid catabolic process (GO:1901606)4.63628134
31serine family amino acid metabolic process (GO:0009069)4.61908175
32cellular ketone body metabolic process (GO:0046950)4.56505693
33urea cycle (GO:0000050)4.53864757
34urea metabolic process (GO:0019627)4.53864757
35positive regulation of glycolytic process (GO:0045821)4.53559629
36short-chain fatty acid metabolic process (GO:0046459)4.52952893
37aspartate family amino acid catabolic process (GO:0009068)4.50897812
38cellular amino acid catabolic process (GO:0009063)4.41413494
39nitric oxide mediated signal transduction (GO:0007263)4.40837200
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.39216962
41indolalkylamine metabolic process (GO:0006586)4.33687366
42phosphate ion transport (GO:0006817)4.32388421
43bile acid metabolic process (GO:0008206)4.31701873
44peptidyl-glutamic acid carboxylation (GO:0017187)4.30978604
45protein carboxylation (GO:0018214)4.30978604
46tyrosine metabolic process (GO:0006570)4.28436341
47regulation of hexokinase activity (GO:1903299)4.27492240
48regulation of glucokinase activity (GO:0033131)4.27492240
49glutamate metabolic process (GO:0006536)4.24088476
50nitrogen cycle metabolic process (GO:0071941)4.20413277
51serine family amino acid biosynthetic process (GO:0009070)4.18156650
52amine catabolic process (GO:0009310)4.17891893
53cellular biogenic amine catabolic process (GO:0042402)4.17891893
54negative regulation of fibrinolysis (GO:0051918)4.13605001
55benzene-containing compound metabolic process (GO:0042537)4.12595708
56endocrine pancreas development (GO:0031018)4.12187507
57response to mercury ion (GO:0046689)4.10682874
58acetyl-CoA metabolic process (GO:0006084)4.10404919
59aldehyde catabolic process (GO:0046185)4.01773817
60valine metabolic process (GO:0006573)4.00270941
61organic cation transport (GO:0015695)3.99201224
62fatty acid beta-oxidation (GO:0006635)3.96698196
63phosphate ion transmembrane transport (GO:0035435)3.95895600
64glycine metabolic process (GO:0006544)3.94260107
65ketone body metabolic process (GO:1902224)3.92551285
66complement activation, alternative pathway (GO:0006957)3.91860316
67carboxylic acid catabolic process (GO:0046395)3.90656586
68organic acid catabolic process (GO:0016054)3.90656586
69regulation of protein activation cascade (GO:2000257)3.90561493
70regulation of fibrinolysis (GO:0051917)3.89224212
712-oxoglutarate metabolic process (GO:0006103)3.88419486
72glycerophospholipid catabolic process (GO:0046475)3.87537659
73regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.87050441
74coenzyme catabolic process (GO:0009109)3.85618573
75fatty acid oxidation (GO:0019395)3.84768148
76inositol phosphate catabolic process (GO:0071545)3.81260069
77cellular glucuronidation (GO:0052695)3.80931447
78branched-chain amino acid metabolic process (GO:0009081)3.80584743
79lipid oxidation (GO:0034440)3.77261780
80negative regulation of sterol transport (GO:0032372)3.75727225
81negative regulation of cholesterol transport (GO:0032375)3.75727225
82dicarboxylic acid biosynthetic process (GO:0043650)3.75479892
83lactate metabolic process (GO:0006089)3.70761185
84monocarboxylic acid catabolic process (GO:0072329)3.69378410
85aminoglycoside antibiotic metabolic process (GO:0030647)3.68383272
86regulation of complement activation (GO:0030449)3.68365941
87glucuronate metabolic process (GO:0019585)3.68290670
88uronic acid metabolic process (GO:0006063)3.68290670
89carnitine metabolic process (GO:0009437)3.65055567
90high-density lipoprotein particle remodeling (GO:0034375)3.64901712
91regulation of cholesterol homeostasis (GO:2000188)3.64477846
92ethanol oxidation (GO:0006069)3.64317324
93fatty acid catabolic process (GO:0009062)3.63879246
94xenobiotic catabolic process (GO:0042178)3.62978812
95branched-chain amino acid catabolic process (GO:0009083)3.62481385
96quaternary ammonium group transport (GO:0015697)3.60942697
97negative regulation of protein oligomerization (GO:0032460)3.59910552
98tricarboxylic acid metabolic process (GO:0072350)3.58552761
99insulin secretion (GO:0030073)3.55933797
100triglyceride homeostasis (GO:0070328)3.52575046
101acylglycerol homeostasis (GO:0055090)3.52575046
102drug metabolic process (GO:0017144)3.51666479
103regulation of triglyceride catabolic process (GO:0010896)3.48953073
104inositol phosphate dephosphorylation (GO:0046855)3.46137135
105phosphorylated carbohydrate dephosphorylation (GO:0046838)3.46137135
106indole-containing compound metabolic process (GO:0042430)3.43559676
107signal peptide processing (GO:0006465)3.43476985
108bile acid and bile salt transport (GO:0015721)3.42794097
109polyol catabolic process (GO:0046174)3.38811389
110aggressive behavior (GO:0002118)3.38689874
111fucose catabolic process (GO:0019317)3.37312778
112L-fucose metabolic process (GO:0042354)3.37312778
113L-fucose catabolic process (GO:0042355)3.37312778
114arginine metabolic process (GO:0006525)3.36112452
115small molecule catabolic process (GO:0044282)3.29524303
116regulation of bile acid biosynthetic process (GO:0070857)3.26174603
117protein-lipid complex remodeling (GO:0034368)3.24639618
118macromolecular complex remodeling (GO:0034367)3.24639618
119plasma lipoprotein particle remodeling (GO:0034369)3.24639618
120dicarboxylic acid metabolic process (GO:0043648)3.23537177
121epoxygenase P450 pathway (GO:0019373)3.20604548
122respiratory chain complex IV assembly (GO:0008535)3.10674966
123vitamin biosynthetic process (GO:0009110)3.02687664
124phenylpropanoid metabolic process (GO:0009698)2.97509927
125positive regulation of insulin secretion (GO:0032024)2.95706831
126protein targeting to Golgi (GO:0000042)2.94042794
127regulation of type B pancreatic cell apoptotic process (GO:2000674)2.91442589
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91406683
129positive regulation of peptide hormone secretion (GO:0090277)2.90713126
130dopamine transport (GO:0015872)2.88905622
131establishment of protein localization to Golgi (GO:0072600)2.88599731
132positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.86742769
133protein prenylation (GO:0018342)2.86479469
134prenylation (GO:0097354)2.86479469
135peptidyl-histidine modification (GO:0018202)2.84288140
136piRNA metabolic process (GO:0034587)2.80274732
137kidney morphogenesis (GO:0060993)2.77314743
138nephron tubule morphogenesis (GO:0072078)2.76720350
139nephron epithelium morphogenesis (GO:0072088)2.76720350
140negative regulation of acute inflammatory response (GO:0002674)2.76299406
141positive regulation of peptide secretion (GO:0002793)2.76191583
142brain morphogenesis (GO:0048854)2.74413500
143preassembly of GPI anchor in ER membrane (GO:0016254)2.73771854
144positive regulation of respiratory burst (GO:0060267)2.72241664
145regulation of mitochondrial translation (GO:0070129)2.71412947
146regulation of glycolytic process (GO:0006110)2.68899760
147cytochrome complex assembly (GO:0017004)2.67702665
148magnesium ion transport (GO:0015693)2.67481533
149renal tubule morphogenesis (GO:0061333)2.66555029
150parental behavior (GO:0060746)2.66395323
151negative regulation of hormone metabolic process (GO:0032351)2.66177607
152artery smooth muscle contraction (GO:0014824)2.65485684
153platelet dense granule organization (GO:0060155)2.65349792
154reverse cholesterol transport (GO:0043691)2.64877859
155protein localization to Golgi apparatus (GO:0034067)2.64285977
156zinc ion homeostasis (GO:0055069)2.63832250
157epithelial cell fate commitment (GO:0072148)2.63172243
158peptide hormone processing (GO:0016486)2.63097359
159DNA deamination (GO:0045006)2.62979538
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62826590
161L-ascorbic acid metabolic process (GO:0019852)2.60037395
162nucleoside diphosphate catabolic process (GO:0009134)2.56990890
163regulation of acrosome reaction (GO:0060046)2.54573149
164type B pancreatic cell development (GO:0003323)2.52930534
165fatty acid homeostasis (GO:0055089)2.51993709
166sphingomyelin metabolic process (GO:0006684)2.49868672
167negative regulation of neurological system process (GO:0031645)2.49638568
168Golgi to endosome transport (GO:0006895)2.49071161
169maternal behavior (GO:0042711)2.48783733
170S-adenosylmethionine metabolic process (GO:0046500)2.46778666
171single strand break repair (GO:0000012)2.46210419
172phospholipid catabolic process (GO:0009395)2.46137483
173rRNA modification (GO:0000154)2.44474514
174response to pheromone (GO:0019236)2.44330736
175intestinal cholesterol absorption (GO:0030299)2.43412469
176purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.40600204
1773-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.40600204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.86404595
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.63392701
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.00688173
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.89595100
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.38658986
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17149244
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.06095100
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72273241
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.42056861
10ZNF274_21170338_ChIP-Seq_K562_Hela3.18894127
11IGF1R_20145208_ChIP-Seq_DFB_Human3.08730775
12GBX2_23144817_ChIP-Seq_PC3_Human2.88253721
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.80432202
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76907413
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.43001505
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.41851540
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38790727
18FUS_26573619_Chip-Seq_HEK293_Human2.36807510
19CLOCK_20551151_ChIP-Seq_293T_Human2.32901523
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26855944
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25259995
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.16281325
23VDR_22108803_ChIP-Seq_LS180_Human2.05760600
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04701736
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7751557
26ER_23166858_ChIP-Seq_MCF-7_Human1.79345241
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78315342
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73417525
29* FOXA2_19822575_ChIP-Seq_HepG2_Human1.69136811
30P300_19829295_ChIP-Seq_ESCs_Human1.68084270
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66014127
32* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64190716
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59726836
34TP53_22573176_ChIP-Seq_HFKS_Human1.59402096
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.59210895
36* HNF4A_19822575_ChIP-Seq_HepG2_Human1.55161527
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52222067
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52070336
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50222085
40AR_25329375_ChIP-Seq_VCAP_Human1.49970395
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49394487
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48918514
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48247079
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.45612675
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.44181107
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43344644
47SMAD4_21799915_ChIP-Seq_A2780_Human1.43167857
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.43024902
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41445725
50SOX2_19829295_ChIP-Seq_ESCs_Human1.40840774
51STAT3_23295773_ChIP-Seq_U87_Human1.39988889
52TCF4_23295773_ChIP-Seq_U87_Human1.39864585
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39272994
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36854640
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32762570
56P53_22387025_ChIP-Seq_ESCs_Mouse1.30374183
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29909904
58EWS_26573619_Chip-Seq_HEK293_Human1.29038290
59* CBP_20019798_ChIP-Seq_JUKART_Human1.28501920
60* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28501920
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27932481
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.24975607
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24975607
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.24553899
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23414353
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22452253
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20437665
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20197280
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19902004
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19902004
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.18422662
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18408449
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18019852
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.16618605
75* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15591855
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15293329
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15170158
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.14455349
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13508559
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13379787
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13237348
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12825968
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.12785094
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12632597
85IRF1_19129219_ChIP-ChIP_H3396_Human1.12410228
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.11789736
87TCF4_22108803_ChIP-Seq_LS180_Human1.11302755
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11129650
89* SRF_21415370_ChIP-Seq_HL-1_Mouse1.11079951
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.10397269
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10323693
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08098638
93P300_18555785_Chip-Seq_ESCs_Mouse1.07441541
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07381013
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07350934
96OCT4_18555785_Chip-Seq_ESCs_Mouse1.05606998
97GATA3_21878914_ChIP-Seq_MCF-7_Human1.04957094
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04423246
99NCOR_22424771_ChIP-Seq_293T_Human1.04390113
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.04238413
101* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03564253
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.02687272
103RUNX2_22187159_ChIP-Seq_PCA_Human1.02397613
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01911770
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.01548776
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.00570416
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.00379666
108REST_21632747_ChIP-Seq_MESCs_Mouse0.99883668
109NMYC_18555785_Chip-Seq_ESCs_Mouse0.99266452
110FLI1_21867929_ChIP-Seq_TH2_Mouse0.99160698
111* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98370247
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.98358009
113* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98097997
114HTT_18923047_ChIP-ChIP_STHdh_Human0.97227351
115AR_21909140_ChIP-Seq_LNCAP_Human0.96334821
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92881288
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.92253413
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91099091
119* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90333515
120GATA4_25053715_ChIP-Seq_YYC3_Human0.90068811
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89527255
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88369326
123RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80895019
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80668238
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78400674
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77686841
127TAF15_26573619_Chip-Seq_HEK293_Human0.70556800
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.68912195
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67280854
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66863902
131MYC_19915707_ChIP-ChIP_AK7_Human0.66720651
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65520703
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63909750
134* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62255774
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.61449001
136SOX2_20726797_ChIP-Seq_SW620_Human0.61387304
137AR_20517297_ChIP-Seq_VCAP_Human0.61136262
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60833803
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.60484954
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59844070
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.59681189
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59535531
143LXR_22292898_ChIP-Seq_THP-1_Human0.57924101
144GATA6_25053715_ChIP-Seq_YYC3_Human0.57235572
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.56777550
146GATA1_22025678_ChIP-Seq_K562_Human0.54795782
147* CBP_21632823_ChIP-Seq_H3396_Human0.54793248
148EGR1_19032775_ChIP-ChIP_M12_Human0.53696408
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.53331788
150BCAT_22108803_ChIP-Seq_LS180_Human0.53068320
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.52935954
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.52749881
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.52294237
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.51945002
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.51568236
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51449414
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51394631
158CDX2_22108803_ChIP-Seq_LS180_Human0.51169121
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.49450728
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.49297338
161STAT1_17558387_ChIP-Seq_HELA_Human0.48025906
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47538506
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47453011
164PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47393481
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47053487
166IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.47045608
167ESR1_15608294_ChIP-ChIP_MCF-7_Human0.46083939
168THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.45985706
169NANOG_16518401_ChIP-PET_MESCs_Mouse0.45510091
170RARA_24833708_ChIP-Seq_LIVER_Mouse0.45399646
171CJUN_26792858_Chip-Seq_BT549_Human0.45328588
172EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.44873604
173CEBPB_22108803_ChIP-Seq_LS180_Human0.44371935
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.44105449
175GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.43436481
176ESET_19884257_ChIP-Seq_ESCs_Mouse0.43017770
177SMAD4_21741376_ChIP-Seq_HESCs_Human0.42455041
178TP63_23658742_ChIP-Seq_EP156T_Human0.42284617
179TP53_18474530_ChIP-ChIP_U2OS_Human0.42112191
180CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.41850159
181NANOG_19829295_ChIP-Seq_ESCs_Human0.41566040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.03141972
2MP0002139_abnormal_hepatobiliary_system7.90370162
3MP0005085_abnormal_gallbladder_physiolo5.31465963
4MP0005365_abnormal_bile_salt5.17329853
5MP0008875_abnormal_xenobiotic_pharmacok4.33422090
6MP0003252_abnormal_bile_duct4.00941246
7MP0003195_calcinosis3.65075870
8MP0005332_abnormal_amino_acid3.62742897
9MP0003787_abnormal_imprinting3.48477334
10MP0003806_abnormal_nucleotide_metabolis3.23014884
11MP0004019_abnormal_vitamin_homeostasis3.15662384
12MP0000013_abnormal_adipose_tissue3.09613950
13MP0005379_endocrine/exocrine_gland_phen2.99507091
14MP0002138_abnormal_hepatobiliary_system2.81215906
15MP0004043_abnormal_pH_regulation2.63810740
16MP0008877_abnormal_DNA_methylation2.61926507
17MP0002163_abnormal_gland_morphology2.55114675
18MP0010329_abnormal_lipoprotein_level2.49667704
19MP0005645_abnormal_hypothalamus_physiol2.44923659
20MP0002909_abnormal_adrenal_gland2.32597641
21MP0009643_abnormal_urine_homeostasis2.24954363
22MP0005646_abnormal_pituitary_gland2.18888941
23MP0002693_abnormal_pancreas_physiology2.18520325
24MP0009046_muscle_twitch1.99615076
25MP0001666_abnormal_nutrient_absorption1.98029321
26MP0005083_abnormal_biliary_tract1.93922625
27MP0003122_maternal_imprinting1.86759204
28MP0005636_abnormal_mineral_homeostasis1.77261889
29MP0005377_hearing/vestibular/ear_phenot1.73443900
30MP0003878_abnormal_ear_physiology1.73443900
31MP0003879_abnormal_hair_cell1.72226001
32MP0005319_abnormal_enzyme/_coenzyme1.68203409
33MP0009840_abnormal_foam_cell1.66041659
34MP0001501_abnormal_sleep_pattern1.65953483
35MP0006072_abnormal_retinal_apoptosis1.64501889
36MP0002118_abnormal_lipid_homeostasis1.59574951
37MP0010386_abnormal_urinary_bladder1.58220539
38MP0005551_abnormal_eye_electrophysiolog1.56082402
39MP0008775_abnormal_heart_ventricle1.55652651
40MP0000609_abnormal_liver_physiology1.55334418
41MP0005410_abnormal_fertilization1.54532151
42MP0003705_abnormal_hypodermis_morpholog1.53969823
43MP0001984_abnormal_olfaction1.52475936
44MP0001756_abnormal_urination1.50692757
45MP0001765_abnormal_ion_homeostasis1.49766282
46MP0009053_abnormal_anal_canal1.47448136
47MP0003186_abnormal_redox_activity1.46907215
48MP0002638_abnormal_pupillary_reflex1.46765180
49MP0005584_abnormal_enzyme/coenzyme_acti1.45601578
50MP0001764_abnormal_homeostasis1.40811168
51MP0008872_abnormal_physiological_respon1.37810492
52MP0003121_genomic_imprinting1.37628027
53MP0003191_abnormal_cellular_cholesterol1.30805842
54MP0002136_abnormal_kidney_physiology1.27975142
55MP0003172_abnormal_lysosome_physiology1.27540677
56MP0004215_abnormal_myocardial_fiber1.24456454
57MP0006054_spinal_hemorrhage1.24019381
58MP0010678_abnormal_skin_adnexa1.21106787
59MP0003868_abnormal_feces_composition1.20731696
60MP0002254_reproductive_system_inflammat1.20300128
61MP0005220_abnormal_exocrine_pancreas1.18608002
62MP0001986_abnormal_taste_sensitivity1.18382845
63MP0002090_abnormal_vision1.16890182
64MP0002928_abnormal_bile_duct1.16388746
65MP0005084_abnormal_gallbladder_morpholo1.16341931
66MP0005253_abnormal_eye_physiology1.15644114
67MP0008438_abnormal_cutaneous_collagen1.15112541
68MP0001968_abnormal_touch/_nociception1.09047776
69MP0001485_abnormal_pinna_reflex1.04504149
70MP0001958_emphysema1.02215944
71MP0001502_abnormal_circadian_rhythm0.98705608
72MP0005367_renal/urinary_system_phenotyp0.98413449
73MP0000516_abnormal_urinary_system0.98413449
74MP0001905_abnormal_dopamine_level0.97365775
75MP0002272_abnormal_nervous_system0.96456512
76MP0000427_abnormal_hair_cycle0.95181130
77MP0005408_hypopigmentation0.93214043
78MP0000598_abnormal_liver_morphology0.92999549
79MP0006276_abnormal_autonomic_nervous0.91990086
80MP0009384_cardiac_valve_regurgitation0.91627257
81MP0005448_abnormal_energy_balance0.90282863
82MP0000569_abnormal_digit_pigmentation0.90205932
83MP0002876_abnormal_thyroid_physiology0.90164164
84MP0005389_reproductive_system_phenotype0.89936552
85MP0000003_abnormal_adipose_tissue0.89803109
86MP0009745_abnormal_behavioral_response0.89562789
87MP0005058_abnormal_lysosome_morphology0.89189316
88MP0003123_paternal_imprinting0.88458593
89MP0000372_irregular_coat_pigmentation0.87717259
90MP0003045_fibrosis0.86862211
91MP0009697_abnormal_copulation0.85763122
92MP0006036_abnormal_mitochondrial_physio0.84411554
93MP0000538_abnormal_urinary_bladder0.83982270
94MP0002160_abnormal_reproductive_system0.83458235
95MP0002557_abnormal_social/conspecific_i0.81619628
96MP0002168_other_aberrant_phenotype0.80283862
97MP0002166_altered_tumor_susceptibility0.79270863
98MP0004085_abnormal_heartbeat0.78861224
99MP0005248_abnormal_Harderian_gland0.78717894
100MP0002938_white_spotting0.78713051
101MP0004145_abnormal_muscle_electrophysio0.78240816
102MP0005535_abnormal_body_temperature0.78123354
103MP0003718_maternal_effect0.78097136
104MP0009642_abnormal_blood_homeostasis0.77874423
105MP0005503_abnormal_tendon_morphology0.77480398
106MP0002837_dystrophic_cardiac_calcinosis0.76639142
107MP0003633_abnormal_nervous_system0.75649544
108MP0005451_abnormal_body_composition0.74449355
109MP0004142_abnormal_muscle_tone0.74345241
110MP0004885_abnormal_endolymph0.73823836
111MP0002896_abnormal_bone_mineralization0.73108937
112MP0002078_abnormal_glucose_homeostasis0.72301229
113MP0002229_neurodegeneration0.71930725
114MP0009764_decreased_sensitivity_to0.71320280
115MP0002572_abnormal_emotion/affect_behav0.70775309
116MP0005464_abnormal_platelet_physiology0.70227891
117MP0001963_abnormal_hearing_physiology0.67951695
118MP0000026_abnormal_inner_ear0.67179437
119MP0003300_gastrointestinal_ulcer0.64037318
120MP0002135_abnormal_kidney_morphology0.62713175
121MP0002115_abnormal_skeleton_extremities0.61512431
122MP0005647_abnormal_sex_gland0.59693109
123MP0001661_extended_life_span0.59321821
124MP0003942_abnormal_urinary_system0.58033534
125MP0002295_abnormal_pulmonary_circulatio0.57321409
126MP0000230_abnormal_systemic_arterial0.57142769
127MP0009672_abnormal_birth_weight0.56618676
128MP0000604_amyloidosis0.55571773
129MP0005395_other_phenotype0.55216578
130MP0004264_abnormal_extraembryonic_tissu0.54216686
131MP0008469_abnormal_protein_level0.54093750
132MP0008961_abnormal_basal_metabolism0.52909339
133MP0001944_abnormal_pancreas_morphology0.52645229
134MP0003959_abnormal_lean_body0.52565388
135MP0009763_increased_sensitivity_to0.51621391
136MP0009780_abnormal_chondrocyte_physiolo0.51487470
137MP0000163_abnormal_cartilage_morphology0.51439709
138MP0005670_abnormal_white_adipose0.51238637
139MP0005376_homeostasis/metabolism_phenot0.49966439
140MP0003638_abnormal_response/metabolism_0.49053264
141MP0003656_abnormal_erythrocyte_physiolo0.48740146
142MP0003329_amyloid_beta_deposits0.47022459
143MP0002282_abnormal_trachea_morphology0.45297971
144MP0002971_abnormal_brown_adipose0.41670023
145MP0006035_abnormal_mitochondrial_morpho0.41380588
146MP0002932_abnormal_joint_morphology0.40892142
147MP0000639_abnormal_adrenal_gland0.40879156
148MP0003953_abnormal_hormone_level0.40287775
149MP0010234_abnormal_vibrissa_follicle0.39732563
150MP0005275_abnormal_skin_tensile0.39389019
151MP0000534_abnormal_ureter_morphology0.39134012
152MP0003011_delayed_dark_adaptation0.38946273
153MP0003283_abnormal_digestive_organ0.37744709
154MP0005334_abnormal_fat_pad0.37537251
155MP0002089_abnormal_postnatal_growth/wei0.37257361
156MP0002249_abnormal_larynx_morphology0.34389524
157MP0005187_abnormal_penis_morphology0.32852030

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.07449321
2Intrahepatic cholestasis (HP:0001406)5.39838722
3Gout (HP:0001997)5.25303195
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.06065619
5Xanthomatosis (HP:0000991)4.86795158
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.85947214
7Deep venous thrombosis (HP:0002625)4.84251584
8Hyperglycinuria (HP:0003108)4.62585209
9Ketosis (HP:0001946)4.52311245
10Hyperinsulinemic hypoglycemia (HP:0000825)4.45795275
11Abnormality of glycine metabolism (HP:0010895)4.34768393
12Abnormality of serine family amino acid metabolism (HP:0010894)4.34768393
13Hypothermia (HP:0002045)4.29925177
14Hyperglycinemia (HP:0002154)4.19022400
15Abnormality of purine metabolism (HP:0004352)4.14968523
16Ketoacidosis (HP:0001993)4.13300033
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08153412
18Hypobetalipoproteinemia (HP:0003563)4.02241633
19Increased circulating renin level (HP:0000848)4.01115375
20Hyperammonemia (HP:0001987)3.99941089
21Hypokalemic alkalosis (HP:0001949)3.87409393
22Proximal tubulopathy (HP:0000114)3.85255820
23Prolonged partial thromboplastin time (HP:0003645)3.84993458
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.79577881
25Hyperglycemia (HP:0003074)3.76981616
26Abnormality of nucleobase metabolism (HP:0010932)3.68844905
27Hyperuricemia (HP:0002149)3.67872172
28Increased purine levels (HP:0004368)3.67872172
29Alkalosis (HP:0001948)3.65399697
30Generalized aminoaciduria (HP:0002909)3.56123419
31Metabolic alkalosis (HP:0200114)3.55885110
32Abnormality of fatty-acid metabolism (HP:0004359)3.50234314
33Large for gestational age (HP:0001520)3.49153320
34Hyperactive renin-angiotensin system (HP:0000841)3.43886767
35Abnormality of the pancreatic islet cells (HP:0006476)3.42156204
36Abnormality of endocrine pancreas physiology (HP:0012093)3.42156204
37Hypoglycemic coma (HP:0001325)3.37736630
38Enlarged kidneys (HP:0000105)3.32884045
39Hypomagnesemia (HP:0002917)3.31469367
40Delayed CNS myelination (HP:0002188)3.26395887
41Complement deficiency (HP:0004431)3.26015063
42Polyuria (HP:0000103)3.25797266
43Abnormal urine output (HP:0012590)3.19923893
44Symptomatic seizures (HP:0011145)3.16061333
45Hyperlipoproteinemia (HP:0010980)3.11115326
46Abnormality of chloride homeostasis (HP:0011422)3.06740070
47Vascular calcification (HP:0004934)2.99796289
48Fat malabsorption (HP:0002630)2.99708067
49Epidermoid cyst (HP:0200040)2.98891359
50Joint hemorrhage (HP:0005261)2.95830524
51Abnormality of the common coagulation pathway (HP:0010990)2.95712317
52Abnormality of renal excretion (HP:0011036)2.93971240
53Abnormality of methionine metabolism (HP:0010901)2.92339457
54Hepatocellular carcinoma (HP:0001402)2.90892134
55Cardiovascular calcification (HP:0011915)2.87635750
56Methylmalonic acidemia (HP:0002912)2.87378260
57Glycosuria (HP:0003076)2.87230822
58Abnormality of urine glucose concentration (HP:0011016)2.87230822
59Hypolipoproteinemia (HP:0010981)2.82951023
60Conjugated hyperbilirubinemia (HP:0002908)2.80954435
61Metabolic acidosis (HP:0001942)2.79621114
62Abnormality of serum amino acid levels (HP:0003112)2.79451928
63Pancreatic cysts (HP:0001737)2.78771001
64Pancreatic fibrosis (HP:0100732)2.76968940
65Abnormality of pyrimidine metabolism (HP:0004353)2.76597669
66Abnormality of vitamin B metabolism (HP:0004340)2.74183945
67Abnormality of magnesium homeostasis (HP:0004921)2.73756274
68Dicarboxylic aciduria (HP:0003215)2.69513986
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69513986
70Tongue fasciculations (HP:0001308)2.69342934
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66928148
72Hydroxyprolinuria (HP:0003080)2.66684526
73Abnormality of proline metabolism (HP:0010907)2.66684526
74Progressive macrocephaly (HP:0004481)2.65362537
75Insulin-resistant diabetes mellitus (HP:0000831)2.63515144
76Rickets (HP:0002748)2.61502547
77Hemiparesis (HP:0001269)2.61197577
78Enlarged penis (HP:0000040)2.61091102
79Pancreatic islet-cell hyperplasia (HP:0004510)2.58643509
80True hermaphroditism (HP:0010459)2.57194059
81Lethargy (HP:0001254)2.56625200
82Methylmalonic aciduria (HP:0012120)2.54507109
83Abnormality of the renal cortex (HP:0011035)2.53344263
84Hyperbilirubinemia (HP:0002904)2.52581882
85Abnormality of vitamin metabolism (HP:0100508)2.52245115
86Abnormality of the intrinsic pathway (HP:0010989)2.50477692
87Abnormal drinking behavior (HP:0030082)2.50275341
88Polydipsia (HP:0001959)2.50275341
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.48653096
90Nephrolithiasis (HP:0000787)2.46830450
91Spastic diplegia (HP:0001264)2.42694860
92Type II lissencephaly (HP:0007260)2.42293167
93Renal tubular acidosis (HP:0001947)2.42146136
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.38345329
95Protuberant abdomen (HP:0001538)2.35146242
96Irritability (HP:0000737)2.34722350
97Hepatic necrosis (HP:0002605)2.33690493
98Abnormal enzyme/coenzyme activity (HP:0012379)2.33556180
99Sensorimotor neuropathy (HP:0007141)2.32906947
100Vomiting (HP:0002013)2.32898601
101Intestinal atresia (HP:0011100)2.32032074
102Hypoalphalipoproteinemia (HP:0003233)2.31524003
1033-Methylglutaconic aciduria (HP:0003535)2.30325486
104Late onset (HP:0003584)2.29354150
105Acute necrotizing encephalopathy (HP:0006965)2.29167107
106Medial flaring of the eyebrow (HP:0010747)2.27097077
107Acute encephalopathy (HP:0006846)2.25770058
108Furrowed tongue (HP:0000221)2.25623008
109Abnormality of renin-angiotensin system (HP:0000847)2.24801669
110Hyperphosphaturia (HP:0003109)2.23104142
111Neonatal onset (HP:0003623)2.22832592
112Chronic hepatic failure (HP:0100626)2.22455875
113Malnutrition (HP:0004395)2.20627446
114Mitral stenosis (HP:0001718)2.20431872
115Skin nodule (HP:0200036)2.20241629
116Abnormality of complement system (HP:0005339)2.18327572
117Renal salt wasting (HP:0000127)2.17405530
118Muscle fibrillation (HP:0010546)2.16857763
119Renal cortical cysts (HP:0000803)2.16525714
120Hypercholesterolemia (HP:0003124)2.15395810
121Tetany (HP:0001281)2.15280350
122Abnormality of alkaline phosphatase activity (HP:0004379)2.14749366
123Congenital stationary night blindness (HP:0007642)2.14590189
124Severe muscular hypotonia (HP:0006829)2.11631590
125Hypophosphatemia (HP:0002148)2.10772972
126Hyperaldosteronism (HP:0000859)2.10522662
127Nephronophthisis (HP:0000090)2.09268048
128Hepatoblastoma (HP:0002884)2.08415595
129Steatorrhea (HP:0002570)2.07006769
130Attenuation of retinal blood vessels (HP:0007843)2.06395461
131Abnormal biliary tract physiology (HP:0012439)2.05772377
132Bile duct proliferation (HP:0001408)2.05772377
133Abnormality of calcium-phosphate metabolism (HP:0100530)2.04644069
134Abnormal sex determination (HP:0012244)2.04347516
135Sex reversal (HP:0012245)2.04347516
136Delayed epiphyseal ossification (HP:0002663)2.02855770
137Aplasia/hypoplasia of the uterus (HP:0008684)2.02396135
138Abnormal urine phosphate concentration (HP:0012599)2.01853911
139Hypoglycemic seizures (HP:0002173)2.01711633
140Decreased circulating renin level (HP:0003351)2.00971560
141Palpitations (HP:0001962)2.00490360
142Cerebral edema (HP:0002181)2.00217101
143Disproportionate short-trunk short stature (HP:0003521)1.99959584
144Increased CSF lactate (HP:0002490)1.99893961
145Gaze-evoked nystagmus (HP:0000640)1.98885137
146Elevated alkaline phosphatase (HP:0003155)1.98123202
147Abnormal cartilage morphology (HP:0002763)1.97360184
148Hypophosphatemic rickets (HP:0004912)1.96587343
149Conjunctival hamartoma (HP:0100780)1.96466026
150Calf muscle hypertrophy (HP:0008981)1.94690509
151Mitochondrial inheritance (HP:0001427)1.94469427
152Abnormal rod and cone electroretinograms (HP:0008323)1.91937637
153Abnormality of the renal medulla (HP:0100957)1.87744539
154Cystic liver disease (HP:0006706)1.84229847
155Abnormal mitochondria in muscle tissue (HP:0008316)1.81808252
156Abnormality of midbrain morphology (HP:0002418)1.80407456
157Molar tooth sign on MRI (HP:0002419)1.80407456
158Potter facies (HP:0002009)1.79156784
159Facial shape deformation (HP:0011334)1.79156784
160Abnormality of the vitamin B12 metabolism (HP:0004341)1.78291921
161EEG with generalized epileptiform discharges (HP:0011198)1.77047849
162Hyperthyroidism (HP:0000836)1.76745878
163Arthropathy (HP:0003040)1.75457473
164Testicular neoplasm (HP:0010788)1.73345788
165Abolished electroretinogram (ERG) (HP:0000550)1.73207104
166Hypokalemia (HP:0002900)1.71029050
167Hyperphosphatemia (HP:0002905)1.70742347
168Abnormal pancreas size (HP:0012094)1.70715920
169Epileptiform EEG discharges (HP:0011182)1.70441293
170Muscle hypertrophy of the lower extremities (HP:0008968)1.70066920
171Stomach cancer (HP:0012126)1.69728709
172Hamartoma of the eye (HP:0010568)1.69352376
173Prominent metopic ridge (HP:0005487)1.68696222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.32327852
2WNK35.56132693
3BCKDK4.76927013
4OXSR14.40788639
5DDR24.18545694
6MAP4K23.34390218
7BMPR1B3.02081948
8MST42.87672732
9FGFR42.84901100
10SIK12.81489851
11STK392.76727288
12PHKG22.68833824
13PHKG12.68833824
14ERN12.54526040
15INSRR2.51612461
16STK38L2.24133751
17ADRBK22.19380706
18EIF2AK32.13495109
19LATS11.99604032
20TRIB31.86198214
21GRK11.82253792
22ERBB41.71376080
23MAP2K61.67936921
24ZAK1.67546492
25ACVR1B1.66905919
26PDK41.64022650
27PDK31.64022650
28FRK1.59471085
29TLK11.57667435
30NTRK31.44917876
31EPHA31.44724179
32TEC1.40907876
33WNK11.37901993
34MST1R1.37572841
35ITK1.36068449
36DYRK1B1.34814183
37PKN21.33115740
38PTK61.31823260
39PASK1.29572334
40BRSK21.23818619
41SGK4941.21274341
42SGK2231.21274341
43ERBB31.20362826
44NEK91.19418183
45PNCK1.19040411
46MAPK111.18109312
47MET1.10834704
48ABL21.09674234
49PDGFRA1.07360818
50MAP3K41.06689026
51EPHB11.06641660
52AKT31.04961325
53FLT31.02779102
54OBSCN1.00474556
55PAK30.98573106
56NTRK10.97055495
57TAOK30.95948377
58PRKCE0.95241882
59RIPK10.94907167
60PTK20.94841887
61MAP2K40.93061636
62MKNK20.92078494
63FGFR20.87507053
64MAPK150.87371392
65PLK20.87334356
66GSK3A0.86824206
67NUAK10.85577826
68PIK3CG0.84236514
69CAMKK20.83484425
70TNK20.81441006
71MAPK130.81286610
72TRPM70.80844083
73PLK30.80486848
74ERBB20.79696092
75PBK0.79606435
76LATS20.79024670
77NEK10.77102559
78VRK10.77013039
79MAPKAPK30.76163832
80SGK20.74455296
81MAP3K140.74419702
82STK380.73272505
83PDK20.72059736
84SGK30.71164744
85PINK10.69977940
86IRAK20.69037633
87PRKCZ0.67967783
88MAP2K70.66439643
89CAMK2D0.64451332
90IRAK10.63191118
91MKNK10.61633088
92MAP3K70.61494645
93STK240.57687907
94DAPK20.57028215
95JAK20.56820453
96TIE10.55359929
97IKBKB0.53351574
98PDPK10.53176831
99MAP3K100.52352278
100CSNK1G10.52246418
101CSNK1A1L0.51982802
102PRKAA10.51973287
103STK30.48308917
104PRKG20.47998304
105CSNK1D0.46794042
106FER0.46775326
107PRKCQ0.46196155
108PRKCG0.45698330
109CDK60.45194573
110CHUK0.44527915
111PRKAA20.44243457
112NLK0.43989001
113CAMK2G0.43404946
114CSF1R0.43122476
115JAK10.42777838
116FGFR10.42343592
117LMTK20.42210099
118HIPK20.41500737
119GRK60.39618809
120STK110.39044175
121EIF2AK20.38980195
122PRKCI0.37863051
123PRKG10.37505369
124MTOR0.37353236
125ATM0.37135770
126ALK0.36596602
127PRKACA0.36188789
128ADRBK10.35974071
129PRKACG0.35852278
130PIK3CA0.35569905
131LRRK20.34596490
132FGFR30.33787276
133RPS6KA50.33650429
134BMX0.32978877
135EPHB20.32355584
136EIF2AK10.30970564
137KIT0.29791557
138CSNK1G30.29714201
139SYK0.29076044
140PTK2B0.27826856
141SGK10.27359680
142CSNK1G20.26917517
143CAMK2A0.26437556
144CSNK1A10.25619949
145CDK30.25548007
146MAP3K20.24073920
147SCYL20.24006117
148PDK10.23305206
149PRKCH0.22622890
150MAP2K10.21319035
151IGF1R0.20447039
152PRKCA0.18600765
153MAPK40.17996235
154RPS6KA40.17527656
155CSNK1E0.17385644
156TESK20.17111237
157PRKD30.16152710
158TYK20.13304552
159PAK40.12986642
160RET0.12227069
161CAMK1D0.11184531
162STK160.10867690
163PAK20.10843772
164ARAF0.10745055
165RPS6KA20.10326333

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.71625099
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50909944
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00874409
4Butanoate metabolism_Homo sapiens_hsa006502.96056465
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92819922
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.87350748
7Tryptophan metabolism_Homo sapiens_hsa003802.76229391
8Nitrogen metabolism_Homo sapiens_hsa009102.71290027
9Fatty acid degradation_Homo sapiens_hsa000712.60379113
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55700040
11Arginine biosynthesis_Homo sapiens_hsa002202.53404483
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49157608
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48320031
14Propanoate metabolism_Homo sapiens_hsa006402.46282872
15Peroxisome_Homo sapiens_hsa041462.41639144
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38223340
17Type I diabetes mellitus_Homo sapiens_hsa049402.36646121
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02391706
19Pyruvate metabolism_Homo sapiens_hsa006201.97916990
20beta-Alanine metabolism_Homo sapiens_hsa004101.94058837
21Insulin secretion_Homo sapiens_hsa049111.93105621
22Sulfur metabolism_Homo sapiens_hsa009201.90912131
23Fatty acid metabolism_Homo sapiens_hsa012121.87213765
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87187977
25Histidine metabolism_Homo sapiens_hsa003401.86155866
26Complement and coagulation cascades_Homo sapiens_hsa046101.85833184
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79555310
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.74608639
29Selenocompound metabolism_Homo sapiens_hsa004501.67606958
30PPAR signaling pathway_Homo sapiens_hsa033201.66496037
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65090466
32Phenylalanine metabolism_Homo sapiens_hsa003601.60061321
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59348940
34Chemical carcinogenesis_Homo sapiens_hsa052041.58525977
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.57209246
36Bile secretion_Homo sapiens_hsa049761.56542955
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55760144
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.54948865
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53443409
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.41055391
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.40856941
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40153424
43Asthma_Homo sapiens_hsa053101.38491255
44Carbon metabolism_Homo sapiens_hsa012001.32075977
45Starch and sucrose metabolism_Homo sapiens_hsa005001.31281363
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31165328
47Folate biosynthesis_Homo sapiens_hsa007901.30554122
48Retinol metabolism_Homo sapiens_hsa008301.29991025
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26628624
50Circadian rhythm_Homo sapiens_hsa047101.26029038
51Arginine and proline metabolism_Homo sapiens_hsa003301.25425083
52Tyrosine metabolism_Homo sapiens_hsa003501.19443009
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.18871596
54Lysine degradation_Homo sapiens_hsa003101.17431694
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15652725
56Vitamin digestion and absorption_Homo sapiens_hsa049771.14339804
57Biosynthesis of amino acids_Homo sapiens_hsa012301.12913741
58Fatty acid elongation_Homo sapiens_hsa000621.09846329
59Renin secretion_Homo sapiens_hsa049241.08607617
60Caffeine metabolism_Homo sapiens_hsa002321.04611252
61Glutathione metabolism_Homo sapiens_hsa004801.04373269
62Steroid biosynthesis_Homo sapiens_hsa001001.01695051
63Phototransduction_Homo sapiens_hsa047441.00266388
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98864357
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92534304
66Staphylococcus aureus infection_Homo sapiens_hsa051500.89051664
67Ether lipid metabolism_Homo sapiens_hsa005650.85839139
68Type II diabetes mellitus_Homo sapiens_hsa049300.85277816
69Circadian entrainment_Homo sapiens_hsa047130.83848468
70Allograft rejection_Homo sapiens_hsa053300.82637691
71ABC transporters_Homo sapiens_hsa020100.81350263
72Autoimmune thyroid disease_Homo sapiens_hsa053200.79672230
73Serotonergic synapse_Homo sapiens_hsa047260.77049744
74Parkinsons disease_Homo sapiens_hsa050120.76613043
75Sulfur relay system_Homo sapiens_hsa041220.67760131
76Fat digestion and absorption_Homo sapiens_hsa049750.67706503
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67096131
78Glycerolipid metabolism_Homo sapiens_hsa005610.66892738
79Salivary secretion_Homo sapiens_hsa049700.65402744
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62642848
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61943881
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61833732
83Dorso-ventral axis formation_Homo sapiens_hsa043200.59039955
84Sphingolipid metabolism_Homo sapiens_hsa006000.58778748
85Graft-versus-host disease_Homo sapiens_hsa053320.58764907
86One carbon pool by folate_Homo sapiens_hsa006700.57076474
87Long-term depression_Homo sapiens_hsa047300.55357496
88Vitamin B6 metabolism_Homo sapiens_hsa007500.54398793
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53240188
90Metabolic pathways_Homo sapiens_hsa011000.50350874
91Protein digestion and absorption_Homo sapiens_hsa049740.49553025
92Pentose phosphate pathway_Homo sapiens_hsa000300.48732692
93Basal transcription factors_Homo sapiens_hsa030220.46362163
94Pancreatic secretion_Homo sapiens_hsa049720.45790209
95Purine metabolism_Homo sapiens_hsa002300.42214467
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42008543
97Rheumatoid arthritis_Homo sapiens_hsa053230.40582865
98Systemic lupus erythematosus_Homo sapiens_hsa053220.37875454
99Homologous recombination_Homo sapiens_hsa034400.35793856
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.35545645
101Taste transduction_Homo sapiens_hsa047420.32912898
102Collecting duct acid secretion_Homo sapiens_hsa049660.32204253
103Cardiac muscle contraction_Homo sapiens_hsa042600.31228230
104Fructose and mannose metabolism_Homo sapiens_hsa000510.29347489
105Insulin resistance_Homo sapiens_hsa049310.21190589
106Thyroid hormone synthesis_Homo sapiens_hsa049180.18230802
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18145443
108Prion diseases_Homo sapiens_hsa050200.17422174
109Galactose metabolism_Homo sapiens_hsa000520.16314522
110Mineral absorption_Homo sapiens_hsa049780.16011593
111Renin-angiotensin system_Homo sapiens_hsa046140.15918646
112Glucagon signaling pathway_Homo sapiens_hsa049220.14186672
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13150680
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12151839
115Other glycan degradation_Homo sapiens_hsa005110.12066906
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11985940
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.09525947
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08627552
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.08238992
120Fatty acid biosynthesis_Homo sapiens_hsa000610.07511633
121Lysosome_Homo sapiens_hsa041420.03115513
122AMPK signaling pathway_Homo sapiens_hsa041520.00792957
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1279032
124ECM-receptor interaction_Homo sapiens_hsa04512-0.1252879
125Oxidative phosphorylation_Homo sapiens_hsa00190-0.1133429
126Regulation of autophagy_Homo sapiens_hsa04140-0.0883497
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0631382
128Protein export_Homo sapiens_hsa03060-0.0488453
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0425021
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0381786
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0361898
132Bladder cancer_Homo sapiens_hsa05219-0.0353017
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0146591
134Linoleic acid metabolism_Homo sapiens_hsa00591-0.0045576

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