ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.04994189
2	response to pheromone (GO:0019236)	7.90533864
3	chromosome condensation (GO:0030261)	7.59889995
4	spermatid development (GO:0007286)	7.58213745
5	negative regulation of inclusion body assembly (GO:0090084)	7.47739884
6	DNA packaging (GO:0006323)	7.18133324
7	spermatid nucleus differentiation (GO:0007289)	7.11138521
8	sperm capacitation (GO:0048240)	7.10157055
9	plasma membrane fusion (GO:0045026)	6.99778610
10	single strand break repair (GO:0000012)	6.98400537
11	rRNA methylation (GO:0031167)	6.80749443
12	multicellular organism reproduction (GO:0032504)	6.71154595
13	sperm-egg recognition (GO:0035036)	6.70413343
14	axonemal dynein complex assembly (GO:0070286)	6.57156137
15	binding of sperm to zona pellucida (GO:0007339)	6.45318454
16	microtubule depolymerization (GO:0007019)	6.03430342
17	reproduction (GO:0000003)	5.95562578
18	calcium ion-dependent exocytosis (GO:0017156)	5.93544518
19	microtubule polymerization or depolymerization (GO:0031109)	5.87082100
20	rRNA modification (GO:0000154)	5.65103837
21	cell-cell recognition (GO:0009988)	5.60162882
22	cilium or flagellum-dependent cell motility (GO:0001539)	5.36456014
23	spermatogenesis (GO:0007283)	5.33765027
24	male gamete generation (GO:0048232)	5.31551041
25	protein targeting to Golgi (GO:0000042)	5.25517560
26	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.18025749
27	protein polyglutamylation (GO:0018095)	5.17201005
28	establishment of protein localization to Golgi (GO:0072600)	5.11069543
29	regulation of inclusion body assembly (GO:0090083)	5.03869871
30	motile cilium assembly (GO:0044458)	5.01941429
31	gamete generation (GO:0007276)	4.89979377
32	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.87616051
33	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.85445010
34	sexual reproduction (GO:0019953)	4.78219507
35	phosphatidylethanolamine metabolic process (GO:0046337)	4.74653035
36	microtubule severing (GO:0051013)	4.69886161
37	cellular ketone body metabolic process (GO:0046950)	4.69256319
38	regulation of transcription involved in cell fate commitment (GO:0060850)	4.60938681
39	regulation of cilium movement (GO:0003352)	4.58486677
40	chromatin silencing (GO:0006342)	4.56009271
41	centriole replication (GO:0007099)	4.55353259
42	germ cell development (GO:0007281)	4.46348049
43	single fertilization (GO:0007338)	4.44092823
44	epithelial cilium movement (GO:0003351)	4.36739157
45	ketone body metabolic process (GO:1902224)	4.28405997
46	cilium movement (GO:0003341)	4.20392864
47	negative regulation of Rho protein signal transduction (GO:0035024)	4.14084375
48	centriole assembly (GO:0098534)	4.09092743
49	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.98573309
50	regulation of Rab GTPase activity (GO:0032313)	3.97939249
51	positive regulation of Rab GTPase activity (GO:0032851)	3.97939249
52	seminiferous tubule development (GO:0072520)	3.90973698
53	multicellular organismal reproductive process (GO:0048609)	3.89951637
54	protein localization to Golgi apparatus (GO:0034067)	3.89198524
55	organic cation transport (GO:0015695)	3.75787928
56	fertilization (GO:0009566)	3.70634267
57	coenzyme catabolic process (GO:0009109)	3.57934640
58	musculoskeletal movement (GO:0050881)	3.54707972
59	multicellular organismal movement (GO:0050879)	3.54707972
60	regulation of centriole replication (GO:0046599)	3.54415992
61	cell wall macromolecule catabolic process (GO:0016998)	3.45650572
62	DNA methylation involved in gamete generation (GO:0043046)	3.42160279
63	cell wall macromolecule metabolic process (GO:0044036)	3.36104200
64	RNA destabilization (GO:0050779)	3.32003630
65	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.30222559
66	nucleus organization (GO:0006997)	3.28030097
67	glycerol ether metabolic process (GO:0006662)	3.27315078
68	positive regulation of action potential (GO:0045760)	3.23547698
69	piRNA metabolic process (GO:0034587)	3.23513807
70	male meiosis (GO:0007140)	3.10655783
71	glomerular epithelial cell development (GO:0072310)	3.10434042
72	glomerular visceral epithelial cell development (GO:0072015)	3.10196382
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.02111249
74	regulation of microtubule-based movement (GO:0060632)	3.00653864
75	peristalsis (GO:0030432)	3.00584461
76	ether metabolic process (GO:0018904)	2.99526380
77	negative regulation of gene expression, epigenetic (GO:0045814)	2.96090084
78	positive regulation of skeletal muscle tissue development (GO:0048643)	2.95334819
79	estrogen biosynthetic process (GO:0006703)	2.91906545
80	response to acidic pH (GO:0010447)	2.91817376
81	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.87706815
82	protein refolding (GO:0042026)	2.83832929
83	nephron epithelium morphogenesis (GO:0072088)	2.83439397
84	nephron tubule morphogenesis (GO:0072078)	2.83439397
85	polyamine biosynthetic process (GO:0006596)	2.78042450
86	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.77340293
87	regulation of somitogenesis (GO:0014807)	2.77266895
88	cell recognition (GO:0008037)	2.71407493
89	cellular response to pH (GO:0071467)	2.69620459
90	ventricular system development (GO:0021591)	2.66999113
91	regulation of interleukin-13 production (GO:0032656)	2.66478771
92	positive regulation of endothelial cell differentiation (GO:0045603)	2.66249206
93	multicellular organismal development (GO:0007275)	2.65798103
94	microtubule nucleation (GO:0007020)	2.65790987
95	centrosome duplication (GO:0051298)	2.60676697
96	artery development (GO:0060840)	2.59784222
97	pattern specification involved in kidney development (GO:0061004)	2.52770967
98	metanephric mesenchyme development (GO:0072075)	2.51676164
99	sperm motility (GO:0030317)	10.6863450
100	acrosome reaction (GO:0007340)	10.5002483

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.04140541
2	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.68486101
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.65454613
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.55329448
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.43600371
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40511475
7	FUS_26573619_Chip-Seq_HEK293_Human	2.35678602
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.33328877
9	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23902064
10	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.23902064
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.05361632
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.05361632
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.01216190
14	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.99328447
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.98148221
16	GATA1_22025678_ChIP-Seq_K562_Human	1.92765021
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.81804719
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73430264
19	P300_19829295_ChIP-Seq_ESCs_Human	1.71713051
20	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71358872
21	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.68287421
22	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.67212551
23	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.56833764
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56159940
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54837549
26	AR_25329375_ChIP-Seq_VCAP_Human	1.52894056
27	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.52713985
28	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52594189
29	ERA_21632823_ChIP-Seq_H3396_Human	1.52389041
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51556943
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49935698
32	TP53_18474530_ChIP-ChIP_U2OS_Human	1.48704938
33	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.45618414
34	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.44447192
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43828645
36	RUNX2_22187159_ChIP-Seq_PCA_Human	1.42461535
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.41123612
38	MYC_19829295_ChIP-Seq_ESCs_Human	1.40813227
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40203765
40	RAC3_21632823_ChIP-Seq_H3396_Human	1.37359908
41	VDR_22108803_ChIP-Seq_LS180_Human	1.37074934
42	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35200765
43	STAT3_23295773_ChIP-Seq_U87_Human	1.34964676
44	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34847180
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34574835
46	CTCF_27219007_Chip-Seq_Bcells_Human	1.33262052
47	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.32131139
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31970129
49	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.30582481
50	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.30125428
51	GBX2_23144817_ChIP-Seq_PC3_Human	1.28586064
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28009635
53	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.27551282
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26864155
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.26318550
56	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25037086
57	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.23768496
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22532712
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22465590
60	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22125218
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.22080387
62	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.21661446
63	RBPJ_21746931_ChIP-Seq_IB4_Human	1.21482556
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21166292
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21166292
66	TBL1_22424771_ChIP-Seq_293T_Human	1.21009006
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20598054
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.20226019
69	AHR_22903824_ChIP-Seq_MCF-7_Human	1.19448598
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19394455
71	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.17671693
72	OCT4_20526341_ChIP-Seq_ESCs_Human	1.17270229
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.17037075
74	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16124621
75	NFYB_21822215_ChIP-Seq_K562_Human	1.14921682
76	PHF8_20622853_ChIP-Seq_HELA_Human	1.14264856
77	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14125693
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.13551696
79	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12253054
80	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12138849
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11932423
82	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.11522255
83	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10027739
84	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.09405766
85	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.08972956
86	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.08972956
87	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08068433
88	NFYA_21822215_ChIP-Seq_K562_Human	1.08064672
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07929713
90	KDM2B_26808549_Chip-Seq_REH_Human	1.07661460
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07327277
92	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05887030
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04996594
94	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.04503486
95	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02594905
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01928331
97	CJUN_26792858_Chip-Seq_BT549_Human	1.01436793
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99956107
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99036904
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.98732516

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.82101274
2	MP0005377_hearing/vestibular/ear_phenot	5.39404095
3	MP0003878_abnormal_ear_physiology	5.39404095
4	MP0003698_abnormal_male_reproductive	3.59466263
5	MP0005670_abnormal_white_adipose	3.40908398
6	MP0001929_abnormal_gametogenesis	3.06305569
7	MP0001485_abnormal_pinna_reflex	2.72179545
8	MP0002234_abnormal_pharynx_morphology	2.47091006
9	MP0001486_abnormal_startle_reflex	2.42420087
10	MP0001348_abnormal_lacrimal_gland	2.04751240
11	MP0002161_abnormal_fertility/fecundity	1.98257449
12	MP0000678_abnormal_parathyroid_gland	1.95694861
13	MP0002249_abnormal_larynx_morphology	1.91894480
14	MP0001984_abnormal_olfaction	1.67505243
15	MP0003718_maternal_effect	1.63902656
16	MP0002138_abnormal_hepatobiliary_system	1.62670603
17	MP0004233_abnormal_muscle_weight	1.61504303
18	MP0002735_abnormal_chemical_nociception	1.58964397
19	MP0002160_abnormal_reproductive_system	1.53041223
20	MP0001963_abnormal_hearing_physiology	1.49837366
21	MP0003879_abnormal_hair_cell	1.49036858
22	MP0005551_abnormal_eye_electrophysiolog	1.46754456
23	MP0001968_abnormal_touch/_nociception	1.43407863
24	MP0004510_myositis	1.43010345
25	MP0004859_abnormal_synaptic_plasticity	1.41011665
26	MP0003136_yellow_coat_color	1.40793344
27	MP0004742_abnormal_vestibular_system	1.39878887
28	MP0002272_abnormal_nervous_system	1.38941369
29	MP0002282_abnormal_trachea_morphology	1.37679559
30	MP0003011_delayed_dark_adaptation	1.32341520
31	MP0002210_abnormal_sex_determination	1.31992773
32	MP0000516_abnormal_urinary_system	1.28897899
33	MP0005367_renal/urinary_system_phenotyp	1.28897899
34	MP0009046_muscle_twitch	1.25621638
35	MP0009745_abnormal_behavioral_response	1.23871932
36	MP0002733_abnormal_thermal_nociception	1.21400446
37	MP0000026_abnormal_inner_ear	1.18454654
38	MP0001145_abnormal_male_reproductive	1.15354227
39	MP0003635_abnormal_synaptic_transmissio	1.13753184
40	MP0000534_abnormal_ureter_morphology	1.13249462
41	MP0000049_abnormal_middle_ear	1.12914761
42	MP0003283_abnormal_digestive_organ	1.12507045
43	MP0001501_abnormal_sleep_pattern	1.10713471
44	MP0002229_neurodegeneration	1.09361154
45	MP0002067_abnormal_sensory_capabilities	1.09352336
46	MP0002928_abnormal_bile_duct	1.08305509
47	MP0005423_abnormal_somatic_nervous	1.07823806
48	MP0001905_abnormal_dopamine_level	1.06477609
49	MP0004085_abnormal_heartbeat	1.05985605
50	MP0000653_abnormal_sex_gland	1.05371079
51	MP0002572_abnormal_emotion/affect_behav	1.05181562
52	MP0002132_abnormal_respiratory_system	1.02773963
53	MP0001879_abnormal_lymphatic_vessel	1.02658531
54	MP0005084_abnormal_gallbladder_morpholo	1.02345758
55	MP0001970_abnormal_pain_threshold	1.01297921
56	MP0003880_abnormal_central_pattern	1.00695640
57	MP0000955_abnormal_spinal_cord	0.99399591
58	MP0005647_abnormal_sex_gland	0.98677239
59	MP0005253_abnormal_eye_physiology	0.97640349
60	MP0001765_abnormal_ion_homeostasis	0.97503661
61	MP0009053_abnormal_anal_canal	0.95250332
62	MP0003646_muscle_fatigue	0.91487554
63	MP0002127_abnormal_cardiovascular_syste	0.89417414
64	MP0002557_abnormal_social/conspecific_i	0.85152562
65	MP0005379_endocrine/exocrine_gland_phen	0.85115293
66	MP0002064_seizures	0.84826331
67	MP0003119_abnormal_digestive_system	0.81456493
68	MP0004885_abnormal_endolymph	0.78775891
69	MP0002734_abnormal_mechanical_nocicepti	0.78494952
70	MP0005395_other_phenotype	0.77483160
71	MP0005646_abnormal_pituitary_gland	0.77074912
72	MP0001270_distended_abdomen	0.74307962
73	MP0002184_abnormal_innervation	0.73670879
74	MP0000681_abnormal_thyroid_gland	0.71580338
75	MP0005310_abnormal_salivary_gland	0.70857415
76	MP0000372_irregular_coat_pigmentation	0.70099658
77	MP0000003_abnormal_adipose_tissue	0.69452207
78	MP0001299_abnormal_eye_distance/	0.68993349
79	MP0000013_abnormal_adipose_tissue	0.68853608
80	MP0001545_abnormal_hematopoietic_system	0.68361447
81	MP0005397_hematopoietic_system_phenotyp	0.68361447
82	MP0005389_reproductive_system_phenotype	0.67930432
83	MP0008877_abnormal_DNA_methylation	0.65878888
84	MP0002752_abnormal_somatic_nervous	0.65174781
85	MP0004484_altered_response_of	0.62107896
86	MP0002063_abnormal_learning/memory/cond	0.60038606
87	MP0002882_abnormal_neuron_morphology	0.58491134
88	MP0006276_abnormal_autonomic_nervous	0.58127871
89	MP0003137_abnormal_impulse_conducting	0.57669818
90	MP0002822_catalepsy	0.55783341
91	MP0004270_analgesia	0.55071886
92	MP0005623_abnormal_meninges_morphology	0.53028661
93	MP0002269_muscular_atrophy	0.52476810
94	MP0005248_abnormal_Harderian_gland	0.52357847
95	MP0000762_abnormal_tongue_morphology	0.49587357
96	MP0005645_abnormal_hypothalamus_physiol	0.49296355
97	MP0005167_abnormal_blood-brain_barrier	0.47283119
98	MP0010368_abnormal_lymphatic_system	0.47126212
99	MP0008789_abnormal_olfactory_epithelium	0.46863519
100	MP0009780_abnormal_chondrocyte_physiolo	0.46257701

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.12876337
2	Absent/shortened dynein arms (HP:0200106)	5.58316600
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.58316600
4	Abnormal ciliary motility (HP:0012262)	5.16696144
5	Abnormal respiratory motile cilium physiology (HP:0012261)	5.03541111
6	Chronic hepatic failure (HP:0100626)	4.94538726
7	Abnormal respiratory epithelium morphology (HP:0012253)	4.64975235
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.64975235
9	Type 2 muscle fiber atrophy (HP:0003554)	4.39778593
10	Attenuation of retinal blood vessels (HP:0007843)	4.26485964
11	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.23666557
12	Muscle fiber atrophy (HP:0100295)	4.12819733
13	Generalized aminoaciduria (HP:0002909)	4.12557267
14	Bony spicule pigmentary retinopathy (HP:0007737)	4.08127021
15	Infertility (HP:0000789)	4.06206143
16	Resting tremor (HP:0002322)	4.03651507
17	Abnormality of macular pigmentation (HP:0008002)	3.67555343
18	Menstrual irregularities (HP:0000858)	3.55945399
19	Male infertility (HP:0003251)	3.53692617
20	Sensory axonal neuropathy (HP:0003390)	3.50091952
21	Abnormal rod and cone electroretinograms (HP:0008323)	3.49655928
22	Fatigable weakness (HP:0003473)	3.46199435
23	Abnormality of the neuromuscular junction (HP:0003398)	3.46199435
24	Tubulointerstitial nephritis (HP:0001970)	3.45651355
25	Hyperkalemia (HP:0002153)	3.40441199
26	Nasal polyposis (HP:0100582)	3.40248859
27	Cone-rod dystrophy (HP:0000548)	3.35045084
28	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.18408065
29	Abnormality of dental color (HP:0011073)	3.14137571
30	Asymmetric septal hypertrophy (HP:0001670)	3.05286428
31	Myokymia (HP:0002411)	3.03021209
32	Rhinitis (HP:0012384)	2.98862070
33	Abnormality of the nasal mucosa (HP:0000433)	2.85243681
34	Unilateral renal agenesis (HP:0000122)	2.78957450
35	Bell-shaped thorax (HP:0001591)	2.70059983
36	Pancreatic fibrosis (HP:0100732)	2.68564371
37	Pendular nystagmus (HP:0012043)	2.63070024
38	True hermaphroditism (HP:0010459)	2.60486011
39	Nephronophthisis (HP:0000090)	2.53753609
40	Postural instability (HP:0002172)	2.53458883
41	Glycosuria (HP:0003076)	2.52609859
42	Abnormality of urine glucose concentration (HP:0011016)	2.52609859
43	Recurrent corneal erosions (HP:0000495)	2.50775596
44	Hypoplastic ischia (HP:0003175)	2.50007183
45	Nonprogressive disorder (HP:0003680)	2.49772574
46	Congenital sensorineural hearing impairment (HP:0008527)	2.49715648
47	Facial shape deformation (HP:0011334)	2.48237466
48	Potter facies (HP:0002009)	2.48237466
49	Progressive cerebellar ataxia (HP:0002073)	2.47969381
50	Decreased central vision (HP:0007663)	2.46285939
51	Weak cry (HP:0001612)	2.44404001
52	Abnormality of the ischium (HP:0003174)	2.38058921
53	Optic nerve hypoplasia (HP:0000609)	2.37201577
54	Chronic bronchitis (HP:0004469)	2.36641599
55	Atonic seizures (HP:0010819)	2.34769840
56	Abnormal drinking behavior (HP:0030082)	2.34060359
57	Polydipsia (HP:0001959)	2.34060359
58	Pancreatic cysts (HP:0001737)	2.32991594
59	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.29252438
60	Sclerocornea (HP:0000647)	2.24621651
61	Hypoalphalipoproteinemia (HP:0003233)	2.21743843
62	Bronchiectasis (HP:0002110)	2.20055814
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19563149
64	Abnormal urine output (HP:0012590)	2.17471979
65	Amelogenesis imperfecta (HP:0000705)	2.17096061
66	Occipital encephalocele (HP:0002085)	2.16999815
67	Renal dysplasia (HP:0000110)	2.16617531
68	Popliteal pterygium (HP:0009756)	2.16576469
69	Abnormal spermatogenesis (HP:0008669)	2.14202515
70	Proximal tubulopathy (HP:0000114)	2.12690537
71	Cystic liver disease (HP:0006706)	2.10407738
72	Abnormality of the renal medulla (HP:0100957)	2.06873131
73	Gonadotropin excess (HP:0000837)	2.06041809
74	Renal Fanconi syndrome (HP:0001994)	2.03429311
75	Osteomalacia (HP:0002749)	2.01505076
76	Abnormality of potassium homeostasis (HP:0011042)	2.01238426
77	Enlarged epiphyses (HP:0010580)	2.00214314
78	Azoospermia (HP:0000027)	1.99472193
79	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.99396186
80	Easy fatigability (HP:0003388)	1.96394199
81	Anencephaly (HP:0002323)	1.94229000
82	Polyuria (HP:0000103)	1.91935153
83	Stage 5 chronic kidney disease (HP:0003774)	1.90657556
84	Median cleft lip (HP:0000161)	1.89479585
85	Truncal obesity (HP:0001956)	1.86627524
86	Abnormality of renal excretion (HP:0011036)	1.85758141
87	Portal hypertension (HP:0001409)	1.83576550
88	Progressive sensorineural hearing impairment (HP:0000408)	1.82624401
89	Impulsivity (HP:0100710)	1.81877330
90	Intellectual disability, moderate (HP:0002342)	1.77112026
91	Congenital hepatic fibrosis (HP:0002612)	1.76899912
92	Fetal akinesia sequence (HP:0001989)	1.75949864
93	Esophageal atresia (HP:0002032)	1.75703797
94	Abolished electroretinogram (ERG) (HP:0000550)	1.74853202
95	Abnormality of the frontal sinuses (HP:0002687)	1.74707788
96	Amblyopia (HP:0000646)	1.74381688
97	Amniotic constriction ring (HP:0009775)	1.73249259
98	Abnormality of placental membranes (HP:0011409)	1.73249259
99	Male pseudohermaphroditism (HP:0000037)	1.72980987
100	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.71901205

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.28954314
2	TESK1	4.40007162
3	MAPK15	3.64788133
4	INSRR	3.00996294
5	DDR2	2.93481438
6	PLK2	2.90246295
7	PINK1	2.88685079
8	PRKD3	2.68014867
9	TSSK6	2.56825518
10	PNCK	2.40056118
11	MAP4K2	2.39380750
12	BRD4	2.25830165
13	STK38	2.25768344
14	FRK	2.17409811
15	STK16	1.94564619
16	STK38L	1.74673164
17	BMPR1B	1.67473529
18	CAMK1G	1.66132193
19	WNK1	1.45411830
20	TLK1	1.31379225
21	FGFR2	1.27359422
22	MUSK	1.26261095
23	PDK1	1.25787053
24	CDK19	1.22022007
25	CAMKK2	1.21638539
26	PDPK1	1.18646265
27	CDK3	1.10520037
28	PTK2B	1.07008000
29	PIK3CG	1.03017509
30	PRKCG	1.02958384
31	LATS2	0.96814861
32	PRKCH	0.93950183
33	TYRO3	0.91661558
34	ADRBK2	0.91476642
35	MARK3	0.86124874
36	TAOK3	0.85378905
37	UHMK1	0.81969033
38	TRIM28	0.80860773
39	NEK6	0.80255263
40	STK39	0.79191274
41	MST1R	0.77586334
42	CAMK1	0.76279354
43	MAPK13	0.72826520
44	TIE1	0.72298033
45	ERBB3	0.71249547
46	SGK494	0.68143075
47	SGK223	0.68143075
48	DYRK1B	0.66526538
49	PDK2	0.65256534
50	IRAK2	0.65160438
51	CDK7	0.64401865
52	CASK	0.63369530
53	CAMK1D	0.63107090
54	MINK1	0.61987401
55	MAPKAPK5	0.61179792
56	NTRK2	0.60146163
57	CAMK4	0.59150801
58	CDK12	0.56343002
59	PRKCE	0.56037848
60	GRK1	0.54120264
61	PRKG2	0.53687914
62	PRKCZ	0.52195073
63	DAPK2	0.51814283
64	TNIK	0.51753554
65	PRKD2	0.51520471
66	OXSR1	0.51076475
67	MKNK2	0.50402442
68	WNK4	0.48567948
69	PRKG1	0.46923215
70	CAMK2A	0.46162246
71	SGK2	0.45250464
72	PRKAA2	0.42612956
73	MAP3K9	0.42511772
74	NTRK3	0.41956922
75	RPS6KA1	0.41815581
76	MARK1	0.40692812
77	MYLK	0.38819190
78	DYRK3	0.38637862
79	VRK1	0.38334714
80	RPS6KA5	0.35431249
81	GRK5	0.33727252
82	ARAF	0.30826856
83	GSK3B	0.29202794
84	SGK3	0.28926993
85	EPHA4	0.27067609
86	PRKACA	0.25958854
87	MAPK10	0.24813674
88	PIK3CA	0.24752640
89	SGK1	0.24618897
90	MAPK1	0.24441197
91	CSNK1G1	0.24253398
92	PRKCB	0.23501586
93	CDK5	0.23381134
94	ROCK1	0.23295020
95	GRK7	0.23041279
96	MAPK8	0.22932039
97	CAMKK1	0.21468147
98	PRKCQ	0.21340367
99	CSNK1G2	0.20399275
100	MAP3K2	0.19815019

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.18317438
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.92288379
3	Olfactory transduction_Homo sapiens_hsa04740	3.45500116
4	Butanoate metabolism_Homo sapiens_hsa00650	3.25730236
5	Taste transduction_Homo sapiens_hsa04742	2.77383589
6	Nicotine addiction_Homo sapiens_hsa05033	2.67392710
7	Morphine addiction_Homo sapiens_hsa05032	1.95367917
8	Phototransduction_Homo sapiens_hsa04744	1.82803499
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79846170
10	GABAergic synapse_Homo sapiens_hsa04727	1.66788084
11	Renin-angiotensin system_Homo sapiens_hsa04614	1.66659131
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.54876772
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.49347224
14	Circadian entrainment_Homo sapiens_hsa04713	1.44574730
15	Amphetamine addiction_Homo sapiens_hsa05031	1.42635445
16	Fatty acid degradation_Homo sapiens_hsa00071	1.40292712
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.39022292
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.28775429
19	Arginine and proline metabolism_Homo sapiens_hsa00330	1.26693536
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25646405
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24255540
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.23895158
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.22850190
24	Retinol metabolism_Homo sapiens_hsa00830	1.21547116
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.20477531
26	Glutamatergic synapse_Homo sapiens_hsa04724	1.19008937
27	Salivary secretion_Homo sapiens_hsa04970	1.18756412
28	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18101116
29	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.17839571
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.17163192
31	Arginine biosynthesis_Homo sapiens_hsa00220	1.13595904
32	cAMP signaling pathway_Homo sapiens_hsa04024	1.11862564
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11768359
34	Cocaine addiction_Homo sapiens_hsa05030	1.10668496
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10079032
36	Phenylalanine metabolism_Homo sapiens_hsa00360	1.07688846
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.07592283
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05480748
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05085852
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04588241
41	Renin secretion_Homo sapiens_hsa04924	1.01924069
42	Tyrosine metabolism_Homo sapiens_hsa00350	0.98687701
43	Type II diabetes mellitus_Homo sapiens_hsa04930	0.98255882
44	Gap junction_Homo sapiens_hsa04540	0.96906516
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.96809501
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.94344208
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91515293
48	Serotonergic synapse_Homo sapiens_hsa04726	0.90711507
49	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.88275202
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.87512916
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87411945
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85484340
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85345299
54	Sulfur relay system_Homo sapiens_hsa04122	0.85117067
55	Cholinergic synapse_Homo sapiens_hsa04725	0.82282713
56	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.81556952
57	Insulin secretion_Homo sapiens_hsa04911	0.80999919
58	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.80750932
59	PPAR signaling pathway_Homo sapiens_hsa03320	0.80071153
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.79815427
61	Gastric acid secretion_Homo sapiens_hsa04971	0.79690073
62	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.78205931
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.77141037
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.75402063
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.73983438
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70600497
67	RNA transport_Homo sapiens_hsa03013	0.66190190
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.64578436
69	Alcoholism_Homo sapiens_hsa05034	0.63987057
70	Protein digestion and absorption_Homo sapiens_hsa04974	0.63330024
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.62917139
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.60362113
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60038394
74	Long-term potentiation_Homo sapiens_hsa04720	0.57692147
75	Circadian rhythm_Homo sapiens_hsa04710	0.53248542
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.52532313
77	Propanoate metabolism_Homo sapiens_hsa00640	0.50554175
78	Endocytosis_Homo sapiens_hsa04144	0.48741091
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45940649
80	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.44532227
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44514734
82	Oocyte meiosis_Homo sapiens_hsa04114	0.44161644
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.44037117
84	Pancreatic secretion_Homo sapiens_hsa04972	0.44017312
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40073355
86	ABC transporters_Homo sapiens_hsa02010	0.40056436
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39783678
88	Graft-versus-host disease_Homo sapiens_hsa05332	0.39617023
89	Allograft rejection_Homo sapiens_hsa05330	0.39575447
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38688290
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.38572714
92	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.37082890
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36139484
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.34868748
95	Tight junction_Homo sapiens_hsa04530	0.34301170
96	Bile secretion_Homo sapiens_hsa04976	0.34295837
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33962510
98	Linoleic acid metabolism_Homo sapiens_hsa00591	0.32827362
99	Purine metabolism_Homo sapiens_hsa00230	0.30255974
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25968625

GAS2L1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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