GAS2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.32707490
2regulation of cilium movement (GO:0003352)7.88201642
3primary alcohol catabolic process (GO:0034310)7.70588623
4vitamin transmembrane transport (GO:0035461)7.15065399
5vitamin catabolic process (GO:0009111)6.58075947
6fat-soluble vitamin catabolic process (GO:0042363)6.58075947
7cilium movement (GO:0003341)6.58060438
8ethanol metabolic process (GO:0006067)6.54136900
9diterpenoid biosynthetic process (GO:0016102)6.08423982
10cilium organization (GO:0044782)5.79972150
11cilium assembly (GO:0042384)5.64469033
12tolerance induction (GO:0002507)5.54160402
13axonemal dynein complex assembly (GO:0070286)5.53727654
14* microtubule bundle formation (GO:0001578)5.47857869
15pyrimidine-containing compound transmembrane transport (GO:0072531)5.40777590
16response to xenobiotic stimulus (GO:0009410)5.35941137
17lung epithelium development (GO:0060428)5.34784314
18one-carbon compound transport (GO:0019755)5.31695445
19regulation of sarcomere organization (GO:0060297)5.18557984
20centriole assembly (GO:0098534)5.04880838
21establishment of apical/basal cell polarity (GO:0035089)4.97454864
22positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.93601724
23axoneme assembly (GO:0035082)4.93145488
24ethanol oxidation (GO:0006069)4.88004147
25negative regulation of B cell mediated immunity (GO:0002713)4.83430500
26negative regulation of immunoglobulin mediated immune response (GO:0002890)4.83430500
27negative regulation of T cell differentiation in thymus (GO:0033085)4.80794440
28protein localization to cilium (GO:0061512)4.78043948
29glomerular epithelial cell development (GO:0072310)4.71790936
30regulation of interleukin-5 production (GO:0032674)4.64465255
31sperm capacitation (GO:0048240)4.64006016
32negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.63507202
33regulation of microtubule-based movement (GO:0060632)4.59811674
34cilium or flagellum-dependent cell motility (GO:0001539)4.58968919
35microtubule-based movement (GO:0007018)4.55334980
36epithelial cilium movement (GO:0003351)4.53989564
37negative regulation of humoral immune response (GO:0002921)4.51565601
38cellular response to vitamin D (GO:0071305)4.50908300
39cellular component assembly involved in morphogenesis (GO:0010927)4.49798030
40regulation of germinal center formation (GO:0002634)4.48535929
41ventricular system development (GO:0021591)4.44265640
42long-chain fatty acid biosynthetic process (GO:0042759)4.43800676
43positive regulation of tolerance induction (GO:0002645)4.38079945
44negative regulation of synaptic transmission, GABAergic (GO:0032229)4.36908914
45establishment or maintenance of monopolar cell polarity (GO:0061339)4.30792630
46establishment of monopolar cell polarity (GO:0061162)4.30792630
47regulation of interleukin-13 production (GO:0032656)4.27247958
48terpenoid biosynthetic process (GO:0016114)4.21739413
49retinoic acid metabolic process (GO:0042573)4.18260738
50cell projection assembly (GO:0030031)4.17324742
51cilium morphogenesis (GO:0060271)4.08508460
52histamine secretion (GO:0001821)4.02349520
53positive regulation of action potential (GO:0045760)4.01214850
54bone trabecula formation (GO:0060346)4.00422421
55response to parathyroid hormone (GO:0071107)3.93689625
56cytoplasmic microtubule organization (GO:0031122)3.91609702
57negative regulation of inclusion body assembly (GO:0090084)3.76538488
58vocalization behavior (GO:0071625)3.76504236
59artery smooth muscle contraction (GO:0014824)3.74923592
60neuronal action potential propagation (GO:0019227)3.69959417
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.66647444
62exogenous drug catabolic process (GO:0042738)3.59017889
63regulation of chemokine-mediated signaling pathway (GO:0070099)3.58218503
64cochlea development (GO:0090102)3.58102758
65phosphorelay signal transduction system (GO:0000160)3.56890362
66glutamate receptor signaling pathway (GO:0007215)3.55648755
67vitamin D metabolic process (GO:0042359)3.52690204
68microtubule depolymerization (GO:0007019)3.52588355
69positive regulation of heart rate (GO:0010460)3.49396822
70GTP biosynthetic process (GO:0006183)3.48809551
71microtubule polymerization or depolymerization (GO:0031109)3.45951612
72lateral ventricle development (GO:0021670)3.43926060
73primary alcohol metabolic process (GO:0034308)3.42334337
74establishment of tissue polarity (GO:0007164)3.38200326
75establishment of planar polarity (GO:0001736)3.38200326
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.34782497
77regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32231717
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31772230
79inositol phosphate-mediated signaling (GO:0048016)3.29237622
80superoxide anion generation (GO:0042554)3.29070657
81regulation of tolerance induction (GO:0002643)3.28352267
82ionotropic glutamate receptor signaling pathway (GO:0035235)3.28338952
83O-glycan processing (GO:0016266)3.27712102
84protein localization to synapse (GO:0035418)3.27453004
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27057222
86tonic smooth muscle contraction (GO:0014820)3.26496806
87positive regulation of protein kinase C signaling (GO:0090037)3.25793345
88retinol metabolic process (GO:0042572)3.25028160
89carnitine metabolic process (GO:0009437)3.24234139
90cellular response to vitamin (GO:0071295)3.18796404
91positive regulation of oligodendrocyte differentiation (GO:0048714)3.17659041
92positive regulation of smoothened signaling pathway (GO:0045880)3.17332508
93positive regulation of cell size (GO:0045793)3.16083994
94response to histamine (GO:0034776)3.15539361
95glutathione derivative biosynthetic process (GO:1901687)3.13875916
96glutathione derivative metabolic process (GO:1901685)3.13875916
97positive regulation of hair follicle development (GO:0051798)3.12771325
98positive regulation of hair cycle (GO:0042635)3.12771325
99axon ensheathment in central nervous system (GO:0032291)3.11706760
100central nervous system myelination (GO:0022010)3.11706760
101hydrogen peroxide biosynthetic process (GO:0050665)3.11472941
102membrane repolarization during action potential (GO:0086011)3.10521961
103positive regulation of odontogenesis (GO:0042482)3.09386031
104histamine transport (GO:0051608)3.09280844
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06999321
106neuron cell-cell adhesion (GO:0007158)3.06712711
107regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06259943
108multicellular organismal water homeostasis (GO:0050891)3.05450360
109regulation of glutamate receptor signaling pathway (GO:1900449)3.05225138
110positive regulation of muscle hypertrophy (GO:0014742)3.04137139
111positive regulation of cardiac muscle hypertrophy (GO:0010613)3.04137139
112aldehyde catabolic process (GO:0046185)3.01899949
113forebrain neuron differentiation (GO:0021879)3.01571458
114nucleoside diphosphate phosphorylation (GO:0006165)3.00167418
115regulation of action potential (GO:0098900)2.99396491
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96694362
117dendritic spine morphogenesis (GO:0060997)2.95685024
118steroid catabolic process (GO:0006706)2.95461015
119locomotory exploration behavior (GO:0035641)2.91372715
120forebrain morphogenesis (GO:0048853)2.90024084
121UTP biosynthetic process (GO:0006228)2.88462333
122response to water (GO:0009415)2.87961747
123motile cilium assembly (GO:0044458)2.85765008
124neuron recognition (GO:0008038)2.85015623
125vascular smooth muscle contraction (GO:0014829)2.84523424
126phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.83746848
127regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83565122
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82787786
129lateral sprouting from an epithelium (GO:0060601)2.81841618
130regulation of sensory perception of pain (GO:0051930)2.79171736
131regulation of sensory perception (GO:0051931)2.79171736
132sperm motility (GO:0030317)2.78726310
133progesterone metabolic process (GO:0042448)2.78656831
134hydrogen peroxide catabolic process (GO:0042744)2.78537952
135drug catabolic process (GO:0042737)2.76399770
136reactive oxygen species biosynthetic process (GO:1903409)2.76391637
137positive regulation of digestive system process (GO:0060456)2.76387867
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75649422
139apical protein localization (GO:0045176)2.74715568
140gamma-aminobutyric acid transport (GO:0015812)2.74591862
141determination of left/right symmetry (GO:0007368)2.73880032
142regulation of response to osmotic stress (GO:0047484)2.72722507
143carnitine transmembrane transport (GO:1902603)2.72527593
144response to auditory stimulus (GO:0010996)2.72201833
145linoleic acid metabolic process (GO:0043651)2.70865136
146branching involved in labyrinthine layer morphogenesis (GO:0060670)2.69455738
147hypotonic response (GO:0006971)2.69162024
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69097538
149oligosaccharide biosynthetic process (GO:0009312)2.68610048
150presynaptic membrane assembly (GO:0097105)2.68206382
151cellular response to epinephrine stimulus (GO:0071872)2.68165521
152phosphatidylcholine biosynthetic process (GO:0006656)2.67796699
153G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67020455
154regulation of autophagic vacuole assembly (GO:2000785)2.64869839
155glutamate secretion (GO:0014047)2.64549806
156UTP metabolic process (GO:0046051)2.64033182
157excretion (GO:0007588)2.63447360
158determination of bilateral symmetry (GO:0009855)2.62857714
159neuron-neuron synaptic transmission (GO:0007270)2.62273954
160transmission of nerve impulse (GO:0019226)2.62271412
161membrane repolarization (GO:0086009)2.62235895
162potassium ion export (GO:0071435)2.61985539
163mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61611592
164positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61380286
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.61371144
166regulation of pigment cell differentiation (GO:0050932)2.60203267
167regulation of synaptic transmission, GABAergic (GO:0032228)2.59561830
168* microtubule-based process (GO:0007017)2.59430301
169water homeostasis (GO:0030104)2.58463285
170regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58128763
171positive regulation of renal sodium excretion (GO:0035815)2.57792985
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57690026
173specification of symmetry (GO:0009799)2.56735616
174intraciliary transport (GO:0042073)2.55885936
175positive regulation of smooth muscle contraction (GO:0045987)2.54511297
176cerebellar granule cell differentiation (GO:0021707)2.54041299
177iron ion import (GO:0097286)2.52906106
178left/right axis specification (GO:0070986)2.51567901
179smoothened signaling pathway (GO:0007224)2.51253366
180CDP-diacylglycerol biosynthetic process (GO:0016024)2.51241351
181organelle assembly (GO:0070925)2.50962170
182negative regulation of cAMP biosynthetic process (GO:0030818)2.50387975
183membrane hyperpolarization (GO:0060081)2.50145554
184multicellular organismal aging (GO:0010259)2.50126753
185polyol transport (GO:0015791)2.49595309
186sodium ion homeostasis (GO:0055078)2.48985139
187regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.47048441
188amino-acid betaine transport (GO:0015838)2.45373547
189carnitine transport (GO:0015879)2.45373547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30559650
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.05066113
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38587917
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.28670532
5GBX2_23144817_ChIP-Seq_PC3_Human3.08452047
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04860581
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03079051
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92449194
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.74954502
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63363241
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.59997274
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59096731
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.55757686
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51622034
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49839732
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49686981
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49686981
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.46917135
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42811286
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34720987
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30285765
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23990205
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20337630
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.08191483
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06653926
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04848432
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.04402836
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02576887
29DROSHA_22980978_ChIP-Seq_HELA_Human2.00776082
30SMC4_20622854_ChIP-Seq_HELA_Human1.99348437
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.97438428
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.96017487
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95121120
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94023293
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.90943023
36AR_21572438_ChIP-Seq_LNCaP_Human1.88886009
37STAT1_20625510_ChIP-Seq_HELA_Human1.88642122
38* REST_21632747_ChIP-Seq_MESCs_Mouse1.82343012
39SMAD4_21799915_ChIP-Seq_A2780_Human1.81437600
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.79420300
41IGF1R_20145208_ChIP-Seq_DFB_Human1.78788117
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76083744
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.72590915
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.69933316
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68755956
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68155077
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63690360
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62276603
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.59763971
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.58013860
51* TP63_22573176_ChIP-Seq_HFKS_Human1.58000397
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57762894
53KLF5_25053715_ChIP-Seq_YYC3_Human1.55165627
54* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54850556
55RNF2_27304074_Chip-Seq_NSC_Mouse1.54499640
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54395520
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.53836944
58P300_19829295_ChIP-Seq_ESCs_Human1.53695422
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53502267
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.51911246
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.51277076
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50371914
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49132759
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48212553
65* TP63_23658742_ChIP-Seq_EP156T_Human1.47141680
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45894181
67TAF15_26573619_Chip-Seq_HEK293_Human1.44216744
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44037340
69SOX2_20726797_ChIP-Seq_SW620_Human1.43404555
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42372346
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42348141
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42176412
73* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.41997953
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41402742
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41192360
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39371333
77GATA1_19941826_ChIP-Seq_K562_Human1.38944154
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38811227
79P68_20966046_ChIP-Seq_HELA_Human1.37473633
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.36142221
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.35668358
82CTCF_27219007_Chip-Seq_Bcells_Human1.35435957
83* RARB_27405468_Chip-Seq_BRAIN_Mouse1.35331475
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35216325
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34972478
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.34560021
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.33810266
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.33230946
89STAT3_23295773_ChIP-Seq_U87_Human1.32702956
90RACK7_27058665_Chip-Seq_MCF-7_Human1.32111083
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31201583
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30600211
93FOXA1_25552417_ChIP-Seq_VCAP_Human1.29877455
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.29136257
95ETV1_20927104_ChIP-Seq_GIST48_Human1.26344531
96RUNX2_22187159_ChIP-Seq_PCA_Human1.25436528
97TP53_16413492_ChIP-PET_HCT116_Human1.24091283
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23667586
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23542371
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.22885099
101CREB1_26743006_Chip-Seq_LNCaP_Human1.22824447
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22033687
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20947498
104VDR_22108803_ChIP-Seq_LS180_Human1.20164460
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20016140
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19073597
107PHF8_20622854_ChIP-Seq_HELA_Human1.19041346
108PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18069088
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17520296
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.16908679
111ER_23166858_ChIP-Seq_MCF-7_Human1.16308429
112PHF8_20622853_ChIP-Seq_HELA_Human1.15932280
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15464995
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15449053
115SMRT_27268052_Chip-Seq_Bcells_Human1.15432092
116LXR_22292898_ChIP-Seq_THP-1_Human1.15327036
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.15173421
118AHR_22903824_ChIP-Seq_MCF-7_Human1.15030289
119* CTCF_20526341_ChIP-Seq_ESCs_Human1.14054842
120HNFA_21074721_ChIP-Seq_CACO-2_Human1.13877750
121TP53_18474530_ChIP-ChIP_U2OS_Human1.13681132
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13667912
123CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13256107
124PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12355223
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12180554
126FOXO3_23340844_ChIP-Seq_DLD1_Human1.11908545
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11497451
128BCAT_22108803_ChIP-Seq_LS180_Human1.11136089
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09929401
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09396261
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09224901
132AR_25329375_ChIP-Seq_VCAP_Human1.08558430
133* TCF4_23295773_ChIP-Seq_U87_Human1.08089262
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.07785957
135GATA3_24758297_ChIP-Seq_MCF-7_Human1.07781851
136GATA4_25053715_ChIP-Seq_YYC3_Human1.07497437
137KDM2B_26808549_Chip-Seq_REH_Human1.07412060
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.07224346
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.07164064
140PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06070917
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.04592553
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04452567
143RBPJ_21746931_ChIP-Seq_IB4_Human1.04167143
144FOXA2_19822575_ChIP-Seq_HepG2_Human1.04093348
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02721098
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01755961
147NFE2_27457419_Chip-Seq_LIVER_Mouse1.01217204
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01199329
149SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00894961
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00628659
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00625220
152FLI1_27457419_Chip-Seq_LIVER_Mouse0.99850254
153P53_22387025_ChIP-Seq_ESCs_Mouse0.99826302
154E2F1_20622854_ChIP-Seq_HELA_Human0.98324171
155P300_27268052_Chip-Seq_Bcells_Human0.98158394
156GATA6_21074721_ChIP-Seq_CACO-2_Human0.97788846
157SA1_27219007_Chip-Seq_ERYTHROID_Human0.97353908
158JUN_21703547_ChIP-Seq_K562_Human0.97090204
159CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97087506
160GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96973192
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.96766596
162CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96555783
163AR_19668381_ChIP-Seq_PC3_Human0.95686477
164CEBPB_22108803_ChIP-Seq_LS180_Human0.95602004
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93401491
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.92823104
167TP53_20018659_ChIP-ChIP_R1E_Mouse0.92783492
168TAL1_26923725_Chip-Seq_HPCs_Mouse0.92664889
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92126498
170TCF4_22108803_ChIP-Seq_LS180_Human0.91973860
171GATA2_19941826_ChIP-Seq_K562_Human0.91373396
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.91126522
173SOX2_21211035_ChIP-Seq_LN229_Human0.90253680
174BCOR_27268052_Chip-Seq_Bcells_Human0.89567711
175EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89555907
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89408035
177POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89408035
178BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89016284
179NFYA_21822215_ChIP-Seq_K562_Human0.87792802
180ZNF263_19887448_ChIP-Seq_K562_Human0.86996764
181SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86635564
182MYC_27129775_Chip-Seq_CORNEA_Mouse0.86295343
183* FLI1_21867929_ChIP-Seq_CD8_Mouse0.86194048
184TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86185096
185RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84469468
186SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84285385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.30442939
2MP0002653_abnormal_ependyma_morphology6.34802796
3MP0002132_abnormal_respiratory_system5.75401556
4MP0003880_abnormal_central_pattern5.28624085
5MP0008004_abnormal_stomach_pH4.75406320
6MP0002277_abnormal_respiratory_mucosa3.91053998
7MP0004859_abnormal_synaptic_plasticity3.84350976
8MP0008789_abnormal_olfactory_epithelium3.18998754
9MP0001188_hyperpigmentation3.05978578
10MP0009745_abnormal_behavioral_response2.99179107
11MP0009046_muscle_twitch2.92686153
12MP0002735_abnormal_chemical_nociception2.85756599
13MP0003635_abnormal_synaptic_transmissio2.82071531
14MP0000566_synostosis2.69944726
15MP0006276_abnormal_autonomic_nervous2.64538857
16MP0003136_yellow_coat_color2.58179813
17MP0002064_seizures2.46458352
18MP0001501_abnormal_sleep_pattern2.44657377
19MP0001486_abnormal_startle_reflex2.35390220
20MP0002272_abnormal_nervous_system2.33167631
21MP0000383_abnormal_hair_follicle2.28699001
22MP0001968_abnormal_touch/_nociception2.27541667
23MP0002822_catalepsy2.23709059
24MP0005377_hearing/vestibular/ear_phenot2.23215485
25MP0003878_abnormal_ear_physiology2.23215485
26MP0005623_abnormal_meninges_morphology2.18063174
27MP0002734_abnormal_mechanical_nocicepti2.16447827
28MP0002063_abnormal_learning/memory/cond2.13901743
29MP0004270_analgesia2.13442998
30MP0002572_abnormal_emotion/affect_behav2.08699647
31MP0009379_abnormal_foot_pigmentation2.08000491
32MP0010678_abnormal_skin_adnexa2.06821639
33MP0005499_abnormal_olfactory_system2.03443965
34MP0005394_taste/olfaction_phenotype2.03443965
35MP0003656_abnormal_erythrocyte_physiolo2.03244858
36MP0002736_abnormal_nociception_after2.03076153
37MP0005083_abnormal_biliary_tract2.00444869
38MP0002168_other_aberrant_phenotype1.99568828
39MP0004019_abnormal_vitamin_homeostasis1.99440769
40MP0002282_abnormal_trachea_morphology1.87184012
41MP0004484_altered_response_of1.78198233
42MP0002160_abnormal_reproductive_system1.76496521
43MP0001346_abnormal_lacrimal_gland1.73706573
44MP0000678_abnormal_parathyroid_gland1.69961301
45MP0004142_abnormal_muscle_tone1.67875398
46MP0005423_abnormal_somatic_nervous1.66854636
47MP0010234_abnormal_vibrissa_follicle1.65923899
48MP0005409_darkened_coat_color1.65139943
49MP0002909_abnormal_adrenal_gland1.61479061
50MP0002067_abnormal_sensory_capabilities1.59245377
51MP0010386_abnormal_urinary_bladder1.56184718
52MP0002733_abnormal_thermal_nociception1.52619932
53MP0000778_abnormal_nervous_system1.51977094
54MP0001485_abnormal_pinna_reflex1.50467833
55MP0002557_abnormal_social/conspecific_i1.49505893
56MP0001905_abnormal_dopamine_level1.48732781
57MP0001970_abnormal_pain_threshold1.43358868
58MP0001765_abnormal_ion_homeostasis1.40804485
59MP0002184_abnormal_innervation1.39882813
60MP0005165_increased_susceptibility_to1.35804851
61MP0001440_abnormal_grooming_behavior1.35393623
62MP0003122_maternal_imprinting1.34425140
63MP0010155_abnormal_intestine_physiology1.34411173
64MP0005551_abnormal_eye_electrophysiolog1.32053224
65MP0009780_abnormal_chondrocyte_physiolo1.30763612
66MP0002249_abnormal_larynx_morphology1.30520000
67MP0004885_abnormal_endolymph1.29695898
68MP0002882_abnormal_neuron_morphology1.23158963
69MP0000465_gastrointestinal_hemorrhage1.21883657
70MP0005395_other_phenotype1.20936216
71MP0003690_abnormal_glial_cell1.20363773
72MP0005636_abnormal_mineral_homeostasis1.19115116
73MP0005248_abnormal_Harderian_gland1.17868193
74MP0010030_abnormal_orbit_morphology1.14782381
75MP0003329_amyloid_beta_deposits1.12160698
76MP0000955_abnormal_spinal_cord1.12016209
77MP0000613_abnormal_salivary_gland1.09399487
78MP0002066_abnormal_motor_capabilities/c1.08445920
79MP0000026_abnormal_inner_ear1.08115041
80MP0003303_peritoneal_inflammation1.07197222
81MP0001963_abnormal_hearing_physiology1.06835517
82MP0005451_abnormal_body_composition1.04729896
83MP0004924_abnormal_behavior1.03019349
84MP0005386_behavior/neurological_phenoty1.03019349
85MP0005646_abnormal_pituitary_gland1.02697813
86MP0002332_abnormal_exercise_endurance1.01358058
87MP0002837_dystrophic_cardiac_calcinosis1.00598760
88MP0001664_abnormal_digestion1.00030279
89MP0004264_abnormal_extraembryonic_tissu0.99206708
90MP0004043_abnormal_pH_regulation0.97263653
91MP0005595_abnormal_vascular_smooth0.96530096
92MP0002139_abnormal_hepatobiliary_system0.95318193
93MP0005645_abnormal_hypothalamus_physiol0.95063911
94MP0009643_abnormal_urine_homeostasis0.94037798
95MP0002752_abnormal_somatic_nervous0.93479861
96MP0002233_abnormal_nose_morphology0.93063362
97MP0006072_abnormal_retinal_apoptosis0.92424239
98MP0000681_abnormal_thyroid_gland0.90630302
99MP0001849_ear_inflammation0.90604088
100MP0005164_abnormal_response_to0.90312623
101MP0005535_abnormal_body_temperature0.89961345
102MP0003633_abnormal_nervous_system0.89764428
103MP0004742_abnormal_vestibular_system0.89579176
104MP0005310_abnormal_salivary_gland0.89343222
105MP0002638_abnormal_pupillary_reflex0.89295962
106MP0002229_neurodegeneration0.88560027
107MP0000920_abnormal_myelination0.87425540
108MP0003941_abnormal_skin_development0.87243462
109MP0003453_abnormal_keratinocyte_physiol0.86364716
110MP0003879_abnormal_hair_cell0.85642881
111MP0001529_abnormal_vocalization0.85152086
112MP0002928_abnormal_bile_duct0.84853091
113MP0010368_abnormal_lymphatic_system0.84686093
114MP0002152_abnormal_brain_morphology0.84454882
115MP0005389_reproductive_system_phenotype0.84008207
116MP0002876_abnormal_thyroid_physiology0.82495728
117MP0002102_abnormal_ear_morphology0.81581126
118MP0000049_abnormal_middle_ear0.80614215
119MP0005379_endocrine/exocrine_gland_phen0.80609579
120MP0002136_abnormal_kidney_physiology0.80383050
121MP0005365_abnormal_bile_salt0.79199173
122MP0004811_abnormal_neuron_physiology0.78963970
123MP0001502_abnormal_circadian_rhythm0.78753390
124MP0004133_heterotaxia0.78006715
125MP0003634_abnormal_glial_cell0.77914797
126MP0002127_abnormal_cardiovascular_syste0.77532083
127MP0001177_atelectasis0.77431841
128MP0005253_abnormal_eye_physiology0.76910690
129MP0005408_hypopigmentation0.76883532
130MP0002098_abnormal_vibrissa_morphology0.76431973
131MP0000579_abnormal_nail_morphology0.76226010
132MP0002108_abnormal_muscle_morphology0.76176769
133MP0003137_abnormal_impulse_conducting0.76086421
134MP0006292_abnormal_olfactory_placode0.75738597
135MP0004883_abnormal_blood_vessel0.73778587
136MP0003631_nervous_system_phenotype0.73670155
137MP0000467_abnormal_esophagus_morphology0.73002174
138MP0004381_abnormal_hair_follicle0.72046254
139MP0004858_abnormal_nervous_system0.68289846
140MP0005220_abnormal_exocrine_pancreas0.67426384
141MP0001270_distended_abdomen0.66017047
142MP0003075_altered_response_to0.65827604
143MP0002069_abnormal_eating/drinking_beha0.65768543
144MP0000762_abnormal_tongue_morphology0.65329471
145MP0002405_respiratory_system_inflammati0.64723847
146MP0000631_abnormal_neuroendocrine_gland0.64695200
147MP0008569_lethality_at_weaning0.63647625
148MP0008874_decreased_physiological_sensi0.63150498
149MP0001984_abnormal_olfaction0.62092150
150MP0003698_abnormal_male_reproductive0.61891931
151MP0001929_abnormal_gametogenesis0.61884098
152MP0005166_decreased_susceptibility_to0.61024529
153MP0001943_abnormal_respiration0.60703745
154MP0000858_altered_metastatic_potential0.57925961
155MP0001299_abnormal_eye_distance/0.56456579
156MP0006082_CNS_inflammation0.56167229
157MP0009765_abnormal_xenobiotic_induced0.55236034
158MP0009763_increased_sensitivity_to0.52897956
159MP0003806_abnormal_nucleotide_metabolis0.52240530
160MP0005085_abnormal_gallbladder_physiolo0.51609093
161MP0003866_abnormal_defecation0.51483435
162MP0002896_abnormal_bone_mineralization0.51148217
163MP0001663_abnormal_digestive_system0.51091431
164MP0005503_abnormal_tendon_morphology0.50540518
165MP0005388_respiratory_system_phenotype0.49890716
166MP0002133_abnormal_respiratory_system0.49890716
167MP0006036_abnormal_mitochondrial_physio0.49677960
168MP0009703_decreased_birth_body0.49170618
169MP0001879_abnormal_lymphatic_vessel0.48568339
170MP0002116_abnormal_craniofacial_bone0.47536082
171MP0005023_abnormal_wound_healing0.46140126
172MP0001324_abnormal_eye_pigmentation0.45925492
173MP0005387_immune_system_phenotype0.44505496
174MP0001790_abnormal_immune_system0.44505496
175MP0001293_anophthalmia0.41498184
176MP0001944_abnormal_pancreas_morphology0.41252071
177MP0002135_abnormal_kidney_morphology0.39458157
178MP0003191_abnormal_cellular_cholesterol0.38960252
179MP0001666_abnormal_nutrient_absorption0.36180434

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.42775423
2Abnormal respiratory motile cilium physiology (HP:0012261)8.66462939
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.30354474
4Rhinitis (HP:0012384)6.26426903
5Abnormal respiratory epithelium morphology (HP:0012253)6.05704751
6Abnormal respiratory motile cilium morphology (HP:0005938)6.05704751
7Oligodactyly (hands) (HP:0001180)5.78598137
8Stenosis of the external auditory canal (HP:0000402)5.67909731
9Split foot (HP:0001839)5.53993649
10Absent/shortened dynein arms (HP:0200106)5.43284456
11Dynein arm defect of respiratory motile cilia (HP:0012255)5.43284456
12Focal motor seizures (HP:0011153)5.27767495
13Bronchitis (HP:0012387)4.37944832
14Elfin facies (HP:0004428)4.22585015
15Recurrent otitis media (HP:0000403)3.95242008
16Oligodactyly (HP:0012165)3.64460185
17Bronchiectasis (HP:0002110)3.44004051
18Chronic bronchitis (HP:0004469)3.38175439
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.37617373
20Focal seizures (HP:0007359)3.25624684
21Chronic otitis media (HP:0000389)3.10953563
22Hyperactive renin-angiotensin system (HP:0000841)3.09818213
23Nasal polyposis (HP:0100582)2.73925002
24Cystic liver disease (HP:0006706)2.71629281
25Ventricular fibrillation (HP:0001663)2.69565013
26Molar tooth sign on MRI (HP:0002419)2.62236407
27Abnormality of midbrain morphology (HP:0002418)2.62236407
28Insidious onset (HP:0003587)2.61159526
29Termporal pattern (HP:0011008)2.61159526
30Pancreatic cysts (HP:0001737)2.59435750
31Myokymia (HP:0002411)2.55922097
32Hemiparesis (HP:0001269)2.52906023
33Dysdiadochokinesis (HP:0002075)2.50262005
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.46353890
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46353890
36Generalized tonic-clonic seizures (HP:0002069)2.38515822
37Severe visual impairment (HP:0001141)2.37143683
38Febrile seizures (HP:0002373)2.36018083
39Tubulointerstitial nephritis (HP:0001970)2.30298381
40Epileptic encephalopathy (HP:0200134)2.29141748
41Postaxial foot polydactyly (HP:0001830)2.28695983
42Chronic hepatic failure (HP:0100626)2.28474148
43Abnormality of dentin (HP:0010299)2.22602200
44Abnormality of the nasal mucosa (HP:0000433)2.21013750
45Polyuria (HP:0000103)2.17060672
46True hermaphroditism (HP:0010459)2.16180003
47Chronic sinusitis (HP:0011109)2.13497256
48Fetal akinesia sequence (HP:0001989)2.11442192
49Bundle branch block (HP:0011710)2.10416703
50Bell-shaped thorax (HP:0001591)2.07125921
51Infertility (HP:0000789)2.07081918
52Visual hallucinations (HP:0002367)2.06542244
53Atonic seizures (HP:0010819)2.05999299
54Dialeptic seizures (HP:0011146)2.05168929
55Abnormality of the corticospinal tract (HP:0002492)2.04840392
56Medial flaring of the eyebrow (HP:0010747)2.03592301
57Progressive cerebellar ataxia (HP:0002073)2.02182378
58Acute necrotizing encephalopathy (HP:0006965)2.01920782
59Pancreatic fibrosis (HP:0100732)1.98856973
60Hyperventilation (HP:0002883)1.98580328
61Abnormal urine output (HP:0012590)1.98309536
62Decreased central vision (HP:0007663)1.96544537
63Absent frontal sinuses (HP:0002688)1.96016994
64Male infertility (HP:0003251)1.95556340
65Absent hand (HP:0004050)1.93917052
66Abnormality of the renal medulla (HP:0100957)1.93272858
67Abnormality of the dental pulp (HP:0006479)1.93243808
68Recurrent bronchitis (HP:0002837)1.93006684
69Decreased circulating renin level (HP:0003351)1.92156560
70Acute encephalopathy (HP:0006846)1.91929489
71Scanning speech (HP:0002168)1.89867905
72Gait imbalance (HP:0002141)1.88651603
73Absence seizures (HP:0002121)1.87447084
74Cerebral inclusion bodies (HP:0100314)1.86767705
75Hemiplegia (HP:0002301)1.86629036
76Anencephaly (HP:0002323)1.85804640
77Renal salt wasting (HP:0000127)1.85516782
78Congenital ichthyosiform erythroderma (HP:0007431)1.85030207
79Recurrent sinusitis (HP:0011108)1.83784493
80Abnormality of renal excretion (HP:0011036)1.81405292
81Urinary urgency (HP:0000012)1.81141666
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.80676825
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.80306878
84Urinary bladder sphincter dysfunction (HP:0002839)1.80289311
85Progressive macrocephaly (HP:0004481)1.79116264
86Occipital encephalocele (HP:0002085)1.78448234
87Male pseudohermaphroditism (HP:0000037)1.78446709
88Asplenia (HP:0001746)1.78397783
89Neurofibrillary tangles (HP:0002185)1.77755708
90Broad-based gait (HP:0002136)1.77512145
91Hydroureter (HP:0000072)1.77330395
92Atelectasis (HP:0100750)1.75529601
93Hyperkalemia (HP:0002153)1.75006589
94Supernumerary spleens (HP:0009799)1.74612527
95Supranuclear gaze palsy (HP:0000605)1.74093866
96Prolonged QT interval (HP:0001657)1.73763034
97Agitation (HP:0000713)1.68115935
98Gaze-evoked nystagmus (HP:0000640)1.66529057
99Impaired vibration sensation in the lower limbs (HP:0002166)1.65762114
100Status epilepticus (HP:0002133)1.65717613
101Congenital primary aphakia (HP:0007707)1.64663443
102Anxiety (HP:0000739)1.64013014
103Severe Myopia (HP:0011003)1.63386071
104Abnormality of macular pigmentation (HP:0008002)1.62436431
105Nephropathy (HP:0000112)1.61120297
106Hypoplastic pelvis (HP:0008839)1.60594530
107Impaired vibratory sensation (HP:0002495)1.58812532
108Abnormal biliary tract physiology (HP:0012439)1.57775925
109Bile duct proliferation (HP:0001408)1.57775925
110Furrowed tongue (HP:0000221)1.56114849
111Rimmed vacuoles (HP:0003805)1.54918136
112Hyperaldosteronism (HP:0000859)1.54758947
113Oculomotor apraxia (HP:0000657)1.54048067
114Abnormal eating behavior (HP:0100738)1.52506908
115Hypercalciuria (HP:0002150)1.51506368
116Tubular atrophy (HP:0000092)1.51265448
117Syncope (HP:0001279)1.51244634
118Abnormal mitochondria in muscle tissue (HP:0008316)1.50616393
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50601082
120Dysmetria (HP:0001310)1.49838262
121Sclerocornea (HP:0000647)1.49737191
122Genital tract atresia (HP:0001827)1.49566657
123Optic disc pallor (HP:0000543)1.49390761
124Torticollis (HP:0000473)1.49284498
125Congenital hepatic fibrosis (HP:0002612)1.49099343
126Septo-optic dysplasia (HP:0100842)1.48166152
127Pulmonic stenosis (HP:0001642)1.47196702
128Nephronophthisis (HP:0000090)1.46394985
129Abnormality of renin-angiotensin system (HP:0000847)1.40833394
130Postaxial hand polydactyly (HP:0001162)1.40440698
131Abnormality of chloride homeostasis (HP:0011422)1.38804245
132Hand muscle atrophy (HP:0009130)1.36361894
133Abnormality of the distal phalanges of the toes (HP:0010182)1.32951386
134Glucose intolerance (HP:0000833)1.32559785
135Nephrogenic diabetes insipidus (HP:0009806)1.31630606
136Short thorax (HP:0010306)1.24932732
137Obstructive sleep apnea (HP:0002870)1.23858337
138Hypokalemic alkalosis (HP:0001949)1.23595005
139Muscle fiber splitting (HP:0003555)1.22741017
140Hyponatremia (HP:0002902)1.21514821
141Abnormality of the frontal sinuses (HP:0002687)1.20356729
142Median cleft lip (HP:0000161)1.20108855
143Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.19905905
144Abnormality of permanent molar morphology (HP:0011071)1.17386307
145Abnormality of the dental root (HP:0006486)1.17386307
146Taurodontia (HP:0000679)1.17386307
147Aplasia of the musculature (HP:0100854)1.16553906
148Preaxial hand polydactyly (HP:0001177)1.16054415
149Short nail (HP:0001799)1.15383908
150Popliteal pterygium (HP:0009756)1.14233790
151Bifid scrotum (HP:0000048)1.12441086
152Stage 5 chronic kidney disease (HP:0003774)1.10567013
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.09287116
154Flat acetabular roof (HP:0003180)1.08428407
155Abnormality of molar morphology (HP:0011070)1.07789871
156Abnormality of molar (HP:0011077)1.07789871
157Tubulointerstitial abnormality (HP:0001969)1.07755196
158Short femoral neck (HP:0100864)1.05241112
159Distal lower limb muscle weakness (HP:0009053)1.05148481
160Stridor (HP:0010307)1.04451864
161Abnormality of monocarboxylic acid metabolism (HP:0010996)1.03925708
162Cone-rod dystrophy (HP:0000548)1.03804478
163Lip pit (HP:0100267)1.03747794
164Poor coordination (HP:0002370)1.03728695
165Limb-girdle muscle atrophy (HP:0003797)1.01780187
166Upper limb amyotrophy (HP:0009129)1.01592099
167Distal upper limb amyotrophy (HP:0007149)1.01592099
168Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.00563303
169Vaginal atresia (HP:0000148)1.00529406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG5.44947084
2TAOK35.16408107
3EPHA24.94004752
4NTRK33.66460761
5MST43.17121592
6EPHA42.75016183
7BCR2.56477214
8TNIK2.53821183
9MAPKAPK32.44603931
10SMG12.37174073
11PNCK2.37136738
12MAPK152.34508177
13CASK2.10280010
14STK392.05747066
15MAP3K21.96502466
16STK241.96303327
17GRK11.90670111
18NTRK21.88568320
19MARK11.76230561
20TTK1.73939869
21CSK1.68420024
22RIPK11.66490419
23MAP3K31.65748008
24FES1.54844747
25GRK71.52597174
26CDC42BPA1.48702316
27MAP3K41.36672978
28EPHB11.31042281
29MINK11.28564621
30IRAK11.27746512
31NEK61.27745104
32RIPK41.27615990
33TNK21.25765369
34MAPK131.23315600
35LRRK21.19124260
36OXSR11.17957428
37MST1R1.15887471
38BLK1.14711097
39PRKCE1.13750287
40CDK51.13206371
41STK101.09574813
42TRIB31.09068894
43TLK11.06660726
44MAP2K71.03784558
45FER1.03753833
46MAP3K71.03138199
47FGR1.02640574
48PRKCG1.02638224
49INSRR1.02422764
50NTRK10.99635444
51TBK10.99551151
52WNK40.98897738
53CAMK2A0.98801193
54BMPR20.98084713
55LMTK20.97319658
56PKN10.95493187
57TESK10.93949826
58CDK190.88681667
59CAMK2B0.85800935
60ICK0.85218025
61GRK50.84175660
62PRPF4B0.82875423
63STK380.81265960
64MAP3K90.79070273
65ADRBK20.76254560
66PTK2B0.74992595
67EPHB20.74744276
68PRKCI0.74402809
69MAPKAPK50.72185566
70MUSK0.71965250
71ROCK20.69805127
72PAK60.69145721
73CAMKK10.68601700
74PHKG10.67985717
75PHKG20.67985717
76PRKG10.66411098
77PLK20.64123824
78ERBB20.63216680
79CAMK2D0.62466686
80GRK60.60721421
81DAPK20.59847067
82YES10.59812121
83ERBB30.59653503
84FYN0.57945186
85WNK10.56564658
86FRK0.56406343
87CAMK1G0.54365812
88MAP3K120.54251086
89MAPK120.52772157
90STK110.52717817
91PRKACA0.52401729
92PRKCQ0.52258527
93TRPM70.52058287
94CAMK2G0.51801660
95SGK10.51541360
96CSNK1A1L0.51335745
97CSNK1E0.50717668
98MAP2K40.49736318
99PAK30.49223308
100NME10.49077832
101EEF2K0.48931266
102PRKCB0.48888706
103PDPK10.46980532
104RPS6KB20.45632182
105DYRK1B0.45106981
106HIPK20.44071076
107CDK140.43618713
108PRKCD0.43444091
109MARK20.43042905
110ADRBK10.42935887
111PRKAA20.42641852
112PRKCA0.42152813
113FGFR20.42066425
114STK160.41899200
115CAMK10.41670959
116PINK10.40968231
117ROCK10.39911930
118AURKA0.38829214
119PRKACB0.38624944
120UHMK10.37498950
121TAOK10.37439631
122RPS6KA30.37012641
123CDK150.36381733
124ABL10.35928182
125BRSK20.35326933
126PRKACG0.34748241
127CSNK1G20.34482776
128CDK180.33807742
129EPHA30.33653037
130SRC0.33062111
131PAK40.31836500
132NLK0.30981350
133CDK60.28224128
134FGFR30.25536517
135AKT20.25234831
136ZAP700.24379390
137PTK60.24160779
138MET0.23678936
139MAP2K20.23475973
140OBSCN0.21398380
141PBK0.20809279
142RPS6KA20.18597749
143LATS10.17983608
144PRKD30.17093857
145PRKD20.16900269
146PRKCZ0.15866979
147RET0.14916127
148MAP3K60.14696708
149STK38L0.14481288
150NEK90.13913822
151PAK10.13139324
152MATK0.12808604
153ILK0.12208114
154TYK20.11699367
155DYRK1A0.11478822
156PDK10.11216710
157PASK0.09616856
158PRKDC0.09544509
159PLK10.09217119
160MYLK0.08678417
161MAP2K10.08491159

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.66881967
2Phenylalanine metabolism_Homo sapiens_hsa003605.19193232
3Chemical carcinogenesis_Homo sapiens_hsa052044.48091347
4Nicotine addiction_Homo sapiens_hsa050334.23221791
5Tyrosine metabolism_Homo sapiens_hsa003503.97811248
6Glutathione metabolism_Homo sapiens_hsa004802.74219669
7Steroid biosynthesis_Homo sapiens_hsa001002.73737283
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57571583
9GABAergic synapse_Homo sapiens_hsa047272.52474074
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35440210
11Morphine addiction_Homo sapiens_hsa050322.32138784
12Caffeine metabolism_Homo sapiens_hsa002322.32099550
13Salivary secretion_Homo sapiens_hsa049702.30904961
14Nitrogen metabolism_Homo sapiens_hsa009102.25885489
15Glutamatergic synapse_Homo sapiens_hsa047242.25271709
16Retinol metabolism_Homo sapiens_hsa008302.19976035
17Taste transduction_Homo sapiens_hsa047422.18664434
18Circadian entrainment_Homo sapiens_hsa047132.06487669
19Linoleic acid metabolism_Homo sapiens_hsa005911.85568084
20Oxidative phosphorylation_Homo sapiens_hsa001901.85290403
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84835441
22Gastric acid secretion_Homo sapiens_hsa049711.83693333
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74390754
24Calcium signaling pathway_Homo sapiens_hsa040201.63367934
25Alzheimers disease_Homo sapiens_hsa050101.62576939
26Renin secretion_Homo sapiens_hsa049241.57835873
27Olfactory transduction_Homo sapiens_hsa047401.56943291
28Long-term potentiation_Homo sapiens_hsa047201.55392954
29Amphetamine addiction_Homo sapiens_hsa050311.54792260
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53783940
31Insulin secretion_Homo sapiens_hsa049111.52724932
32Serotonergic synapse_Homo sapiens_hsa047261.52365742
33Huntingtons disease_Homo sapiens_hsa050161.51466955
34Melanogenesis_Homo sapiens_hsa049161.49401667
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47847096
36Cardiac muscle contraction_Homo sapiens_hsa042601.47815482
37Synaptic vesicle cycle_Homo sapiens_hsa047211.42394570
38Butanoate metabolism_Homo sapiens_hsa006501.41739004
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40664462
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39790517
41Long-term depression_Homo sapiens_hsa047301.38475845
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35924958
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.35799829
44Fatty acid degradation_Homo sapiens_hsa000711.34449874
45Propanoate metabolism_Homo sapiens_hsa006401.34157634
46ABC transporters_Homo sapiens_hsa020101.32998465
47Cholinergic synapse_Homo sapiens_hsa047251.32391071
48Cocaine addiction_Homo sapiens_hsa050301.29219571
49Parkinsons disease_Homo sapiens_hsa050121.28035679
50Dopaminergic synapse_Homo sapiens_hsa047281.27990748
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24974710
52Phototransduction_Homo sapiens_hsa047441.16610850
53Axon guidance_Homo sapiens_hsa043601.14571186
54Pancreatic secretion_Homo sapiens_hsa049721.13477794
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12477947
56GnRH signaling pathway_Homo sapiens_hsa049121.08789765
57Oxytocin signaling pathway_Homo sapiens_hsa049211.08554641
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06626308
59Peroxisome_Homo sapiens_hsa041461.06484517
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.06422832
61Arachidonic acid metabolism_Homo sapiens_hsa005901.06181814
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05731900
63Hedgehog signaling pathway_Homo sapiens_hsa043401.04411798
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01601818
65Gap junction_Homo sapiens_hsa045401.01359297
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99043246
67cAMP signaling pathway_Homo sapiens_hsa040240.97061392
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96184501
69Starch and sucrose metabolism_Homo sapiens_hsa005000.94997402
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93984378
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91904469
72Ovarian steroidogenesis_Homo sapiens_hsa049130.90772699
73Fatty acid elongation_Homo sapiens_hsa000620.84413422
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83737190
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.82283529
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80112913
77Collecting duct acid secretion_Homo sapiens_hsa049660.78070187
78Histidine metabolism_Homo sapiens_hsa003400.78013769
79Notch signaling pathway_Homo sapiens_hsa043300.77183825
80Dilated cardiomyopathy_Homo sapiens_hsa054140.76555324
81Basal cell carcinoma_Homo sapiens_hsa052170.75931131
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74823521
83Bile secretion_Homo sapiens_hsa049760.73774678
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.72742407
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72493384
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71888995
87Ether lipid metabolism_Homo sapiens_hsa005650.71529157
88Hepatitis C_Homo sapiens_hsa051600.71239324
89Estrogen signaling pathway_Homo sapiens_hsa049150.70870675
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70367945
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.67448311
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.66997532
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66266069
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64331963
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.63045553
96Adherens junction_Homo sapiens_hsa045200.62599487
97Type II diabetes mellitus_Homo sapiens_hsa049300.61157060
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.60640280
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.58475351
100Inositol phosphate metabolism_Homo sapiens_hsa005620.58362495
101beta-Alanine metabolism_Homo sapiens_hsa004100.57778196
102PPAR signaling pathway_Homo sapiens_hsa033200.56780355
103ErbB signaling pathway_Homo sapiens_hsa040120.55391526
104Wnt signaling pathway_Homo sapiens_hsa043100.52655570
105Tight junction_Homo sapiens_hsa045300.52105347
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50150807
107Dorso-ventral axis formation_Homo sapiens_hsa043200.49560413
108Mineral absorption_Homo sapiens_hsa049780.47424966
109Fatty acid biosynthesis_Homo sapiens_hsa000610.46132072
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45617641
111African trypanosomiasis_Homo sapiens_hsa051430.44407345
112Hematopoietic cell lineage_Homo sapiens_hsa046400.44373334
113Glucagon signaling pathway_Homo sapiens_hsa049220.44126606
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42936761
115Vibrio cholerae infection_Homo sapiens_hsa051100.42390837
116Complement and coagulation cascades_Homo sapiens_hsa046100.40629867
117Thyroid hormone synthesis_Homo sapiens_hsa049180.40162605
118Amoebiasis_Homo sapiens_hsa051460.38881259
119Circadian rhythm_Homo sapiens_hsa047100.37957127
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36018261
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36014939
122Hippo signaling pathway_Homo sapiens_hsa043900.35053147
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34910267
124Sphingolipid metabolism_Homo sapiens_hsa006000.34832578
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33808877
126Arginine and proline metabolism_Homo sapiens_hsa003300.33218361
127Ras signaling pathway_Homo sapiens_hsa040140.33131855
128Choline metabolism in cancer_Homo sapiens_hsa052310.31099015
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29946294
130Lysosome_Homo sapiens_hsa041420.29705216
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29370463
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29295496
133Protein digestion and absorption_Homo sapiens_hsa049740.28746038
134Glycerolipid metabolism_Homo sapiens_hsa005610.28322176
135Vitamin digestion and absorption_Homo sapiens_hsa049770.28309138
136Metabolic pathways_Homo sapiens_hsa011000.28015152
137Insulin resistance_Homo sapiens_hsa049310.27249062
138Rap1 signaling pathway_Homo sapiens_hsa040150.26988222
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26507948
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23680489
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.21095676
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.19046616
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14781296
144Type I diabetes mellitus_Homo sapiens_hsa049400.13750906
145Pyruvate metabolism_Homo sapiens_hsa006200.13353263
146Endocytosis_Homo sapiens_hsa041440.12959652
147Fructose and mannose metabolism_Homo sapiens_hsa000510.08468958
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08444080
149Allograft rejection_Homo sapiens_hsa053300.07509282
150Phagosome_Homo sapiens_hsa041450.07163513
151Arginine biosynthesis_Homo sapiens_hsa002200.06935415
152Autoimmune thyroid disease_Homo sapiens_hsa053200.06117253
153Tryptophan metabolism_Homo sapiens_hsa003800.05566037

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