GAS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)4.53213924
2kidney mesenchyme development (GO:0072074)4.27049142
3protein heterotrimerization (GO:0070208)4.07393257
4barbed-end actin filament capping (GO:0051016)3.96089581
5negative regulation of smooth muscle cell migration (GO:0014912)3.85923869
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.84558741
7fibril organization (GO:0097435)3.71083819
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.70516935
9metanephric mesenchyme development (GO:0072075)3.67845227
10regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.52068316
11collagen fibril organization (GO:0030199)3.52064169
12hemidesmosome assembly (GO:0031581)3.50101108
13cell adhesion mediated by integrin (GO:0033627)3.49235395
14tooth mineralization (GO:0034505)3.43729506
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.42624004
16blood vessel maturation (GO:0001955)3.29788442
17endodermal cell differentiation (GO:0035987)3.28992284
18hypotonic response (GO:0006971)3.24966925
19positive regulation of blood vessel endothelial cell migration (GO:0043536)3.22337253
20adherens junction assembly (GO:0034333)3.21072823
21mesenchymal-epithelial cell signaling (GO:0060638)3.20468183
22collagen metabolic process (GO:0032963)3.16401533
23focal adhesion assembly (GO:0048041)3.15831152
24cell-substrate adherens junction assembly (GO:0007045)3.15831152
25venous blood vessel morphogenesis (GO:0048845)3.12295766
26collagen catabolic process (GO:0030574)3.11704363
27epithelial cell-cell adhesion (GO:0090136)3.10986045
28keratan sulfate catabolic process (GO:0042340)3.10925170
29neuron projection extension involved in neuron projection guidance (GO:1902284)3.07085551
30axon extension involved in axon guidance (GO:0048846)3.07085551
31multicellular organismal macromolecule metabolic process (GO:0044259)3.05651813
32cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.05633613
33skin morphogenesis (GO:0043589)2.98016979
34multicellular organismal catabolic process (GO:0044243)2.96155215
35multicellular organismal metabolic process (GO:0044236)2.93681109
36cellular response to vitamin D (GO:0071305)2.93522329
37actin filament depolymerization (GO:0030042)2.91822313
38basement membrane organization (GO:0071711)2.90165628
39* apoptotic cell clearance (GO:0043277)2.88807539
40vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88779219
41regulation of plasminogen activation (GO:0010755)2.87022543
42hyaluronan catabolic process (GO:0030214)2.85521313
43* adhesion of symbiont to host cell (GO:0044650)2.85455501
44* virion attachment to host cell (GO:0019062)2.85455501
45regulation of extracellular matrix disassembly (GO:0010715)2.84377179
46regulation of tight junction assembly (GO:2000810)2.82673520
47desmosome organization (GO:0002934)2.82469213
48positive regulation of osteoblast proliferation (GO:0033690)2.82095515
49extracellular matrix disassembly (GO:0022617)2.80965267
50cortical actin cytoskeleton organization (GO:0030866)2.79820964
51regulation of early endosome to late endosome transport (GO:2000641)2.79674497
52atrioventricular valve morphogenesis (GO:0003181)2.79633119
53extracellular negative regulation of signal transduction (GO:1900116)2.77987389
54extracellular regulation of signal transduction (GO:1900115)2.77987389
55positive regulation of receptor recycling (GO:0001921)2.77160534
56regulation of integrin-mediated signaling pathway (GO:2001044)2.75197990
57* cellular response to vitamin (GO:0071295)2.74646668
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.74506161
59regulation of smooth muscle cell migration (GO:0014910)2.71998143
60positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71148099
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70615375
62low-density lipoprotein particle clearance (GO:0034383)2.70035898
63negative regulation of osteoblast proliferation (GO:0033689)2.69698650
64dermatan sulfate metabolic process (GO:0030205)2.68518630
65endocytic recycling (GO:0032456)2.68090928
66positive regulation of p38MAPK cascade (GO:1900745)2.66490281
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65828240
68smooth muscle tissue development (GO:0048745)2.64251722
69peptidyl-proline hydroxylation (GO:0019511)2.63784122
70positive regulation of fatty acid beta-oxidation (GO:0032000)2.63567205
71muscle cell migration (GO:0014812)2.63409891
72trabecula formation (GO:0060343)2.63267824
73regulation of establishment of planar polarity (GO:0090175)2.61702236
74cell migration involved in sprouting angiogenesis (GO:0002042)2.61513800
75positive regulation of axon extension (GO:0045773)2.61306242
76regulation of collagen metabolic process (GO:0010712)2.60518791
77vascular endothelial growth factor signaling pathway (GO:0038084)2.59391236
78negative regulation of fatty acid transport (GO:2000192)2.59305573
79sequestering of extracellular ligand from receptor (GO:0035581)2.57429218
80substrate adhesion-dependent cell spreading (GO:0034446)2.57173387
81negative regulation of BMP signaling pathway (GO:0030514)2.56910150
82plasma membrane repair (GO:0001778)2.56838028
83embryo implantation (GO:0007566)2.56650461
84cell-substrate junction assembly (GO:0007044)2.56321003
85cortical cytoskeleton organization (GO:0030865)2.54925006
86glial cell migration (GO:0008347)2.54274762
87fibroblast migration (GO:0010761)2.54193354
88bone trabecula formation (GO:0060346)2.52113187
89positive regulation of endothelial cell apoptotic process (GO:2000353)2.52018866
90protein hydroxylation (GO:0018126)2.51500319
91mannose metabolic process (GO:0006013)2.51417063
92growth hormone receptor signaling pathway (GO:0060396)2.51000570
93positive regulation of fatty acid oxidation (GO:0046321)2.50618810
94regulation of fatty acid beta-oxidation (GO:0031998)2.48638871
95chondrocyte proliferation (GO:0035988)2.48008214
96regulation of p38MAPK cascade (GO:1900744)2.47837832
97stress fiber assembly (GO:0043149)2.44842051
98protein localization to endosome (GO:0036010)2.43819308
99wound healing, spreading of epidermal cells (GO:0035313)2.43552731
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.38681679
101sodium ion export (GO:0071436)2.38256436
102endothelial cell morphogenesis (GO:0001886)2.34035708
103type B pancreatic cell proliferation (GO:0044342)2.32128012
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.31597631
105renal filtration (GO:0097205)2.29487555
106glomerular basement membrane development (GO:0032836)2.28817234
107cellular response to growth hormone stimulus (GO:0071378)2.27320121
108cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27093644
109regulation of membrane protein ectodomain proteolysis (GO:0051043)2.22644940
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21706648
111regulation of fatty acid oxidation (GO:0046320)2.21459035
112glomerular filtration (GO:0003094)2.20090503
113protein retention in ER lumen (GO:0006621)2.19358160
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19185596
115negative regulation of chondrocyte differentiation (GO:0032331)2.17217065
116* cellular response to nutrient (GO:0031670)2.15865894
117fatty acid transmembrane transport (GO:1902001)2.15488636
118surfactant homeostasis (GO:0043129)2.15244144
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.14891599
120carnitine shuttle (GO:0006853)2.13498134
121positive regulation of glycogen biosynthetic process (GO:0045725)2.13481217
122semaphorin-plexin signaling pathway (GO:0071526)2.12229568
123response to fluid shear stress (GO:0034405)2.12221707
124lysine metabolic process (GO:0006553)2.12192085
125lysine catabolic process (GO:0006554)2.12192085
126* extracellular matrix organization (GO:0030198)2.09825292
127* extracellular structure organization (GO:0043062)2.08847807
128substrate-dependent cell migration (GO:0006929)2.08511892
129positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.08083700
130epoxygenase P450 pathway (GO:0019373)2.06448178
131Golgi transport vesicle coating (GO:0048200)2.05602338
132COPI coating of Golgi vesicle (GO:0048205)2.05602338
133extracellular fibril organization (GO:0043206)2.05527364
134endocardial cushion development (GO:0003197)2.05521787
135* extracellular matrix assembly (GO:0085029)2.05380595
136cardiac myofibril assembly (GO:0055003)2.05213656
137peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.04388381
138regulation of cholesterol storage (GO:0010885)2.03516731
139regulation of macrophage cytokine production (GO:0010935)2.02952877
140positive regulation of macrophage cytokine production (GO:0060907)2.02946836
141negative regulation of cardiac muscle tissue growth (GO:0055022)2.00987794
142negative regulation of heart growth (GO:0061117)2.00987794
143collecting duct development (GO:0072044)2.00724883
144heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.00717173
145cell communication involved in cardiac conduction (GO:0086065)1.98999368
146bone morphogenesis (GO:0060349)1.98673446
147prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060521.98331375
148wound healing, spreading of cells (GO:0044319)1.97871255
149ventricular cardiac muscle cell action potential (GO:0086005)1.97668925
150valine metabolic process (GO:0006573)1.97652081
151fatty acid beta-oxidation (GO:0006635)1.97006210
152negative regulation of catenin import into nucleus (GO:0035414)1.96575599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.20041147
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.15142426
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26122679
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.25020980
5CLOCK_20551151_ChIP-Seq_293T_Human2.81994803
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.38117370
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21025753
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.18736979
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.15735208
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.07976033
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02514506
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01402491
13* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96146732
14RXR_22158963_ChIP-Seq_LIVER_Mouse1.87851489
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.76411783
16* LXR_22158963_ChIP-Seq_LIVER_Mouse1.74526788
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.71024786
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68738512
19* CJUN_26792858_Chip-Seq_BT549_Human1.67264870
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66963909
21* TP53_22127205_ChIP-Seq_IMR90_Human1.65436351
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62386966
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61373570
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.55526091
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54758008
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52266231
27NFIB_24661679_ChIP-Seq_LUNG_Mouse1.51754105
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50211618
29SMC3_22415368_ChIP-Seq_MEFs_Mouse1.49442490
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49081081
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47529414
32* UBF1/2_26484160_Chip-Seq_HMECs_Human1.45127501
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44664779
34* TBX20_22328084_ChIP-Seq_HEART_Mouse1.41891404
35* TBX20_22080862_ChIP-Seq_HEART_Mouse1.41891404
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39684217
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.39212086
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.39199569
39LXR_22292898_ChIP-Seq_THP-1_Human1.39047151
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37060589
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36760030
42* TP53_23651856_ChIP-Seq_MEFs_Mouse1.35211493
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34528503
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34528503
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34406670
46* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32872747
47* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32872747
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32006761
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.31304120
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31046802
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29774269
52ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28242023
53SA1_22415368_ChIP-Seq_MEFs_Mouse1.26237791
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26149122
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.25029768
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24858499
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21563676
58* SOX2_20726797_ChIP-Seq_SW620_Human1.21389274
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20915251
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20589206
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20215747
62ZNF263_19887448_ChIP-Seq_K562_Human1.18974347
63KDM2B_26808549_Chip-Seq_K562_Human1.17929874
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17655343
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17590153
66* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17577111
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16965536
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16410839
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.15895972
70* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15407287
71TP53_18474530_ChIP-ChIP_U2OS_Human1.15275552
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15129913
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15031006
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12572341
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12482653
76* DROSHA_22980978_ChIP-Seq_HELA_Human1.12184458
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.11656226
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10968140
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10582699
80* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10134409
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08717385
82* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07666402
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06438629
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.05816429
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05378468
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05256544
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03785074
88* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03607509
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03255937
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.03215368
91AHR_22903824_ChIP-Seq_MCF-7_Human1.03153977
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03046522
93* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02284230
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02050658
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.01788945
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01635270
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.01236770
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01104758
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.00971694
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00804905
101* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00209424
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99595090
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98859054
104* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98549773
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98347904
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98206867
107* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98062306
108* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97594651
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.97212812
110SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96429411
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95155835
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.94340480
113* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92508572
114* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92508572
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92070406
116* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90884068
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90251316
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.89775356
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89409179
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88615187
121* ATF3_27146783_Chip-Seq_COLON_Human0.88376324
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88218421
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86986915
124AR_21572438_ChIP-Seq_LNCaP_Human0.86309329
125BRD4_25478319_ChIP-Seq_HGPS_Human0.86267073
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86159586
127RXR_22108803_ChIP-Seq_LS180_Human0.86146289
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85686155
129KDM2B_26808549_Chip-Seq_DND41_Human0.85120922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.64773530
2MP0005275_abnormal_skin_tensile4.77447168
3MP0003705_abnormal_hypodermis_morpholog4.20281191
4MP0005503_abnormal_tendon_morphology3.64904514
5MP0001958_emphysema3.57439124
6MP0003279_aneurysm2.94249206
7MP0004272_abnormal_basement_membrane2.37211114
8MP0009384_cardiac_valve_regurgitation2.36442351
9MP0002254_reproductive_system_inflammat2.30028092
10MP0003566_abnormal_cell_adhesion2.13061778
11MP0005058_abnormal_lysosome_morphology2.11945209
12MP0000751_myopathy1.87937204
13MP0003300_gastrointestinal_ulcer1.86176382
14MP0005623_abnormal_meninges_morphology1.83486205
15MP0002295_abnormal_pulmonary_circulatio1.83223174
16MP0003950_abnormal_plasma_membrane1.79955516
17MP0002060_abnormal_skin_morphology1.76059246
18MP0005023_abnormal_wound_healing1.61863909
19MP0002837_dystrophic_cardiac_calcinosis1.61220792
20MP0005257_abnormal_intraocular_pressure1.59254597
21MP0004185_abnormal_adipocyte_glucose1.58810514
22MP0004084_abnormal_cardiac_muscle1.58299835
23MP0010030_abnormal_orbit_morphology1.56879979
24MP0006054_spinal_hemorrhage1.54308009
25MP0003941_abnormal_skin_development1.53991434
26MP0004130_abnormal_muscle_cell1.53909819
27MP0010234_abnormal_vibrissa_follicle1.52298189
28MP0000013_abnormal_adipose_tissue1.46686084
29MP0005508_abnormal_skeleton_morphology1.45280470
30MP0002877_abnormal_melanocyte_morpholog1.41271024
31MP0010368_abnormal_lymphatic_system1.36639018
32MP0003045_fibrosis1.36152250
33MP0002108_abnormal_muscle_morphology1.35573927
34MP0002896_abnormal_bone_mineralization1.33943087
35MP0005666_abnormal_adipose_tissue1.33133526
36MP0003191_abnormal_cellular_cholesterol1.25387879
37MP0001542_abnormal_bone_strength1.23542175
38MP0005670_abnormal_white_adipose1.23329619
39MP0004858_abnormal_nervous_system1.18967811
40MP0000516_abnormal_urinary_system1.18427833
41MP0005367_renal/urinary_system_phenotyp1.18427833
42MP0000759_abnormal_skeletal_muscle1.17734021
43MP0003091_abnormal_cell_migration1.14987921
44MP0010352_gastrointestinal_tract_polyps1.14335120
45MP0001348_abnormal_lacrimal_gland1.13429364
46MP0005375_adipose_tissue_phenotype1.11861615
47MP0002168_other_aberrant_phenotype1.09644818
48MP0003252_abnormal_bile_duct1.08791044
49MP0004036_abnormal_muscle_relaxation1.08491970
50MP0001849_ear_inflammation1.07556614
51MP0002998_abnormal_bone_remodeling1.07177256
52MP0005360_urolithiasis1.06123082
53MP0000733_abnormal_muscle_development1.04070410
54MP0000343_altered_response_to1.03340969
55MP0000762_abnormal_tongue_morphology1.01868525
56MP0000767_abnormal_smooth_muscle1.01791280
57MP0004510_myositis1.00176779
58MP0000538_abnormal_urinary_bladder0.97379880
59MP0008775_abnormal_heart_ventricle0.96812194
60MP0009840_abnormal_foam_cell0.94513285
61MP0004087_abnormal_muscle_fiber0.93145252
62MP0001533_abnormal_skeleton_physiology0.92329581
63MP0005390_skeleton_phenotype0.92086921
64MP0002090_abnormal_vision0.92048944
65MP0009278_abnormal_bone_marrow0.91927561
66MP0001756_abnormal_urination0.91099527
67MP0000604_amyloidosis0.91036660
68MP0000750_abnormal_muscle_regeneration0.90874000
69MP0009053_abnormal_anal_canal0.90848815
70MP0002933_joint_inflammation0.90575708
71MP0005330_cardiomyopathy0.90028899
72MP0000003_abnormal_adipose_tissue0.90005342
73MP0000428_abnormal_craniofacial_morphol0.88285681
74MP0003283_abnormal_digestive_organ0.87801816
75MP0003453_abnormal_keratinocyte_physiol0.87520154
76MP0006138_congestive_heart_failure0.87103947
77MP0003448_altered_tumor_morphology0.87044933
78MP0005165_increased_susceptibility_to0.86888717
79MP0002133_abnormal_respiratory_system0.86782450
80MP0005388_respiratory_system_phenotype0.86782450
81MP0008004_abnormal_stomach_pH0.86484288
82MP0009780_abnormal_chondrocyte_physiolo0.86110937
83MP0003942_abnormal_urinary_system0.86087842
84MP0000462_abnormal_digestive_system0.85689790
85MP0002796_impaired_skin_barrier0.85298253
86MP0000858_altered_metastatic_potential0.85157113
87MP0003075_altered_response_to0.83858033
88MP0002115_abnormal_skeleton_extremities0.83069985
89MP0005595_abnormal_vascular_smooth0.82823763
90MP0001299_abnormal_eye_distance/0.79664433
91MP0001243_abnormal_dermal_layer0.79561442
92MP0005620_abnormal_muscle_contractility0.78980018
93MP0002972_abnormal_cardiac_muscle0.76759304
94MP0000747_muscle_weakness0.76706487
95MP0000163_abnormal_cartilage_morphology0.76252633
96MP0010329_abnormal_lipoprotein_level0.76221019
97MP0003172_abnormal_lysosome_physiology0.75952513
98MP0009250_abnormal_appendicular_skeleto0.75073411
99MP0005409_darkened_coat_color0.75062039
100MP0002113_abnormal_skeleton_development0.74605322
101MP0001614_abnormal_blood_vessel0.73992862
102MP0000534_abnormal_ureter_morphology0.73245975
103MP0005197_abnormal_uvea_morphology0.72905168
104MP0005164_abnormal_response_to0.72745702
105MP0000749_muscle_degeneration0.72167571
106MP0003329_amyloid_beta_deposits0.72098807
107MP0001879_abnormal_lymphatic_vessel0.71754080
108MP0010386_abnormal_urinary_bladder0.71538254
109MP0005385_cardiovascular_system_phenoty0.71073611
110MP0001544_abnormal_cardiovascular_syste0.71073611
111MP0003795_abnormal_bone_structure0.70494589
112MP0000467_abnormal_esophagus_morphology0.69799711
113MP0008961_abnormal_basal_metabolism0.69439845
114MP0003385_abnormal_body_wall0.69278403
115MP0002139_abnormal_hepatobiliary_system0.68205896
116* MP0009643_abnormal_urine_homeostasis0.68072878
117MP0004233_abnormal_muscle_weight0.68000067
118MP0001177_atelectasis0.67507797
119MP0002128_abnormal_blood_circulation0.67345330
120MP0005167_abnormal_blood-brain_barrier0.65516437
121MP0004883_abnormal_blood_vessel0.64596893
122MP0003828_pulmonary_edema0.64232823
123MP0005332_abnormal_amino_acid0.64137548
124MP0004134_abnormal_chest_morphology0.62986912
125MP0005369_muscle_phenotype0.61486606
126MP0002932_abnormal_joint_morphology0.60326316
127MP0001915_intracranial_hemorrhage0.59975925
128MP0000432_abnormal_head_morphology0.59544675
129MP0001175_abnormal_lung_morphology0.59505345
130MP0005076_abnormal_cell_differentiation0.58911748
131MP0002089_abnormal_postnatal_growth/wei0.57541726
132MP0002249_abnormal_larynx_morphology0.57180824

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.55909551
2Premature rupture of membranes (HP:0001788)5.87865686
3Aortic aneurysm (HP:0004942)4.46492608
4Aortic dissection (HP:0002647)4.37847615
5Broad metatarsal (HP:0001783)4.36984875
6Atrophic scars (HP:0001075)4.33480311
7Cerebral aneurysm (HP:0004944)4.07575893
8Ankle contracture (HP:0006466)4.00187472
9Right ventricular cardiomyopathy (HP:0011663)3.76117993
10Shallow orbits (HP:0000586)3.71037429
11Peritonitis (HP:0002586)3.42405571
12Fragile skin (HP:0001030)3.41844041
13Bladder diverticulum (HP:0000015)3.27706837
14Type 1 muscle fiber predominance (HP:0003803)3.27487242
15Soft skin (HP:0000977)3.12391352
16Vascular tortuosity (HP:0004948)3.10109752
17Dilatation of the ascending aorta (HP:0005111)3.05784999
18Blue sclerae (HP:0000592)2.99816740
19Vertebral compression fractures (HP:0002953)2.96158899
20Increased connective tissue (HP:0009025)2.95629774
21Arterial tortuosity (HP:0005116)2.88833853
22Mitral valve prolapse (HP:0001634)2.75422350
23Aneurysm (HP:0002617)2.73391060
24Cervical subluxation (HP:0003308)2.72749869
25Aortic regurgitation (HP:0001659)2.72097967
26Mitral regurgitation (HP:0001653)2.68244054
27Asymmetric septal hypertrophy (HP:0001670)2.65032032
28Follicular hyperkeratosis (HP:0007502)2.63785407
29Dysostosis multiplex (HP:0000943)2.55289295
30Abnormality of dentin (HP:0010299)2.55286396
31Spinal rigidity (HP:0003306)2.54784578
32Increased variability in muscle fiber diameter (HP:0003557)2.52714595
33Wormian bones (HP:0002645)2.50704317
34Hypoventilation (HP:0002791)2.49168014
35Genu recurvatum (HP:0002816)2.49085656
36Neonatal short-limb short stature (HP:0008921)2.48621180
37Generalized amyotrophy (HP:0003700)2.40543986
38Hyperextensible skin (HP:0000974)2.38528509
39Increased cerebral lipofuscin (HP:0011813)2.38495192
40Distal lower limb amyotrophy (HP:0008944)2.31187648
41Mucopolysacchariduria (HP:0008155)2.29540148
42Urinary glycosaminoglycan excretion (HP:0003541)2.29540148
43Mildly elevated creatine phosphokinase (HP:0008180)2.26584498
44Short nail (HP:0001799)2.26454631
45Thin bony cortex (HP:0002753)2.26391889
46Scapular winging (HP:0003691)2.26325639
47Natal tooth (HP:0000695)2.25726790
48Ectopia lentis (HP:0001083)2.25099691
49Distal lower limb muscle weakness (HP:0009053)2.21523227
50Hyporeflexia of lower limbs (HP:0002600)2.21477554
51Aortic valve stenosis (HP:0001650)2.21402940
52Ulnar bowing (HP:0003031)2.18834786
53Upper limb amyotrophy (HP:0009129)2.15618832
54Distal upper limb amyotrophy (HP:0007149)2.15618832
55Lymphangioma (HP:0100764)2.15117641
56Overgrowth (HP:0001548)2.13730826
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13309637
58Abnormality of polysaccharide metabolism (HP:0011012)2.13309637
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13309637
60Abnormality of skeletal muscle fiber size (HP:0012084)2.12389920
61Biconcave vertebral bodies (HP:0004586)2.11301420
62Striae distensae (HP:0001065)2.09708346
63Hand muscle atrophy (HP:0009130)2.08784709
64Systemic lupus erythematosus (HP:0002725)2.08035077
65Mild short stature (HP:0003502)2.07943170
66Long toe (HP:0010511)2.04165760
67Bowel diverticulosis (HP:0005222)2.03008816
68Osteolytic defects of the hand bones (HP:0009699)2.00874952
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.00874952
70Muscle fiber splitting (HP:0003555)2.00095356
71Wrist flexion contracture (HP:0001239)1.99729437
72Joint stiffness (HP:0001387)1.97809117
73Round ear (HP:0100830)1.95653392
74Limb-girdle muscle weakness (HP:0003325)1.94692231
75Coronal craniosynostosis (HP:0004440)1.93420728
76Nonimmune hydrops fetalis (HP:0001790)1.92751753
77Ulnar deviation of the wrist (HP:0003049)1.92350599
78Abnormality of the acetabulum (HP:0003170)1.91216061
79Complement deficiency (HP:0004431)1.89791270
80Breech presentation (HP:0001623)1.88686770
81Hydroxyprolinuria (HP:0003080)1.88200774
82Abnormality of proline metabolism (HP:0010907)1.88200774
83Ovoid vertebral bodies (HP:0003300)1.85982233
84Spondylolisthesis (HP:0003302)1.84742703
85Wide anterior fontanel (HP:0000260)1.84510061
86Bradycardia (HP:0001662)1.84318799
87Abnormal delivery (HP:0001787)1.83847399
88Disproportionate tall stature (HP:0001519)1.83202473
89Femoral bowing (HP:0002980)1.82698046
90Joint laxity (HP:0001388)1.81969422
91Camptodactyly of toe (HP:0001836)1.81500672
92Turricephaly (HP:0000262)1.81279730
93Protruding ear (HP:0000411)1.81104522
94Slender build (HP:0001533)1.80929839
95Lower limb amyotrophy (HP:0007210)1.80879752
96Osteopenia (HP:0000938)1.80381079
97Ventricular tachycardia (HP:0004756)1.80303080
98Difficulty climbing stairs (HP:0003551)1.80054658
99Elbow flexion contracture (HP:0002987)1.79873233
100Axonal loss (HP:0003447)1.76819039
101Abnormality of skull ossification (HP:0002703)1.75870450
102Mitral stenosis (HP:0001718)1.75670768
103Deviation of the hallux (HP:0010051)1.75658811
104Increased neuronal autofluorescent lipopigment (HP:0002074)1.75379154
105Nephritis (HP:0000123)1.73168144
106Hallux valgus (HP:0001822)1.73142827
107Cardiovascular calcification (HP:0011915)1.72971501
108Emphysema (HP:0002097)1.72066562
109Hyperacusis (HP:0010780)1.71923239
110Venous abnormality (HP:0002624)1.69784258
111Hematochezia (HP:0002573)1.69485613
112Knee flexion contracture (HP:0006380)1.69340373
113Bowing of the arm (HP:0006488)1.68224935
114Bowed forearm bones (HP:0003956)1.68224935
115Broad ribs (HP:0000885)1.67646318
116Sudden death (HP:0001699)1.67394617
117Delayed cranial suture closure (HP:0000270)1.67232503
118Vacuolated lymphocytes (HP:0001922)1.66669452
119Inguinal hernia (HP:0000023)1.66366384
120Difficulty running (HP:0009046)1.66231458
121Facial diplegia (HP:0001349)1.66104761
122Achilles tendon contracture (HP:0001771)1.65554069
123Coxa vara (HP:0002812)1.64964712
124Broad face (HP:0000283)1.64215634
125Obstructive sleep apnea (HP:0002870)1.63576218
126Ventricular arrhythmia (HP:0004308)1.63517549
127Abnormality of the Achilles tendon (HP:0005109)1.62974645
128Osteoarthritis (HP:0002758)1.62806158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.18931211
2ERN13.59990351
3TTN3.18617390
4RIPK12.78993814
5PKN22.60916185
6TGFBR22.39361588
7DDR22.31451602
8SIK12.30905676
9LMTK22.29707692
10PDGFRA2.29444538
11LATS22.16545760
12MYLK2.03685399
13LIMK12.03486438
14FER1.88871550
15EPHA31.88136843
16LATS11.85070413
17PRKD21.74794706
18MOS1.73008448
19EPHB11.72525270
20PTK61.62592567
21EPHB21.52902829
22CAMK1D1.50438204
23PRPF4B1.48733973
24FGFR41.43750125
25WNK41.43635770
26PIM21.43499853
27MAP3K61.39959169
28DMPK1.35260809
29PTK21.31393683
30GRK71.30733695
31EPHA21.29896095
32PAK21.26347288
33FLT31.26345755
34ARAF1.23700598
35CAMK1G1.22861539
36PHKG21.22124861
37PHKG11.22124861
38BCKDK1.18614011
39PTK2B1.17523553
40ABL21.13282793
41FGFR21.12082734
42FRK1.11535016
43PAK31.11018548
44NTRK11.09753817
45LRRK21.08541158
46PDK41.08051150
47PDK31.08051150
48TAOK21.07241793
49STK381.06863360
50MAP3K31.04553411
51PAK41.02675336
52MAPK151.00772435
53KSR21.00663454
54RET0.99887486
55PIK3CA0.98592599
56JAK10.97096301
57PDGFRB0.93581767
58MAPKAPK30.92770178
59PIK3CG0.92311647
60MAP2K10.92183782
61IRAK30.89613941
62SMG10.89255347
63MAPK70.88859071
64MST1R0.88525141
65MET0.87550601
66CAMKK10.86802699
67PDK20.85733363
68TIE10.83789514
69ADRBK10.83656764
70PRKD10.83573753
71ROCK10.82612231
72MAP3K20.81392388
73BMX0.75540005
74SCYL20.74497119
75DAPK20.74421369
76GRK50.74302279
77TESK10.74075680
78NEK90.73007007
79CDC42BPA0.71842786
80AKT30.70238840
81FGFR30.70079772
82DAPK30.69438822
83TYK20.69411124
84PAK60.69224600
85EEF2K0.67933039
86MAP3K70.66333901
87TAOK10.65174826
88CAMKK20.64757376
89MAP2K30.64747597
90RPS6KL10.64045284
91RPS6KC10.64045284
92MTOR0.61425000
93MAP3K90.60420244
94PAK10.59738648
95CAMK2G0.59683974
96FGFR10.58553405
97KIT0.58326728
98MARK20.56425761
99ERBB40.56167655
100JAK20.55128537
101STK38L0.54585403
102WNK10.54247428
103PRKD30.54171452
104GSK3A0.54112368
105MAP3K130.52945054
106PRKCH0.52879433
107MAPK120.51264513
108TRPM70.49550249
109ILK0.48342941
110ZAP700.47559975
111CDK60.47191715
112TBK10.47124926
113BRAF0.45740721
114DYRK1B0.45395304
115PDPK10.45061497
116ICK0.44630273
117SRC0.43935465
118RPS6KA60.43832574
119TESK20.43702317
120MAP3K10.43435855
121MAP2K20.43218138
122ROCK20.42594603
123MAPKAPK20.42203700
124NME20.42190041
125MUSK0.41411486
126ERBB20.40713745
127PRKG20.40415540
128MAPK40.40373074
129NEK10.38742235
130RPS6KA20.37856880
131PRKAA20.35594082
132WNK30.34574343
133OXSR10.33612984
134CAMK2D0.32770888
135HIPK20.31900764
136JAK30.29117014
137MELK0.28372224
138CAMK2B0.27132059

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.50715313
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.00792183
3Focal adhesion_Homo sapiens_hsa045101.78346506
4Lysosome_Homo sapiens_hsa041421.74477204
5Protein digestion and absorption_Homo sapiens_hsa049741.72114068
6Fatty acid degradation_Homo sapiens_hsa000711.68590785
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59699490
8PPAR signaling pathway_Homo sapiens_hsa033201.54558112
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50299931
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50223078
11Dilated cardiomyopathy_Homo sapiens_hsa054141.50197326
12Caffeine metabolism_Homo sapiens_hsa002321.47754524
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44675822
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42383648
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39798671
16Nitrogen metabolism_Homo sapiens_hsa009101.36764355
17Amoebiasis_Homo sapiens_hsa051461.35397388
18Fatty acid metabolism_Homo sapiens_hsa012121.32966517
19Propanoate metabolism_Homo sapiens_hsa006401.30857466
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26628039
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23931918
22Other glycan degradation_Homo sapiens_hsa005111.21103173
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18608684
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17895655
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15636876
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15468319
27Proteoglycans in cancer_Homo sapiens_hsa052051.13735123
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12824478
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10161202
30Bile secretion_Homo sapiens_hsa049761.08906298
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06940047
32Melanogenesis_Homo sapiens_hsa049160.99259503
33Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99200685
34Insulin resistance_Homo sapiens_hsa049310.98916614
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98467404
36Bladder cancer_Homo sapiens_hsa052190.98362848
37Gap junction_Homo sapiens_hsa045400.98211889
38Staphylococcus aureus infection_Homo sapiens_hsa051500.97000280
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.96713530
40MicroRNAs in cancer_Homo sapiens_hsa052060.94949326
41Vibrio cholerae infection_Homo sapiens_hsa051100.94490617
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94416643
43Adherens junction_Homo sapiens_hsa045200.94121166
44Pathways in cancer_Homo sapiens_hsa052000.93998453
45Hedgehog signaling pathway_Homo sapiens_hsa043400.92016802
46Complement and coagulation cascades_Homo sapiens_hsa046100.88644513
47Basal cell carcinoma_Homo sapiens_hsa052170.87410822
48Malaria_Homo sapiens_hsa051440.86709954
49Axon guidance_Homo sapiens_hsa043600.85781782
50Butanoate metabolism_Homo sapiens_hsa006500.84326194
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.84279093
52Pyruvate metabolism_Homo sapiens_hsa006200.82378053
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82288460
54Pertussis_Homo sapiens_hsa051330.81929910
55Galactose metabolism_Homo sapiens_hsa000520.80994793
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80970112
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80254516
58N-Glycan biosynthesis_Homo sapiens_hsa005100.78019248
59Shigellosis_Homo sapiens_hsa051310.77752057
60Tryptophan metabolism_Homo sapiens_hsa003800.77145289
61Gastric acid secretion_Homo sapiens_hsa049710.76555609
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76143653
63Notch signaling pathway_Homo sapiens_hsa043300.75809846
64Starch and sucrose metabolism_Homo sapiens_hsa005000.75560314
65Mineral absorption_Homo sapiens_hsa049780.75388688
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.73379180
67TNF signaling pathway_Homo sapiens_hsa046680.72831267
68Phagosome_Homo sapiens_hsa041450.70737278
69Small cell lung cancer_Homo sapiens_hsa052220.69711847
70Toxoplasmosis_Homo sapiens_hsa051450.69551213
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69200848
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68503680
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67806928
74Glycerolipid metabolism_Homo sapiens_hsa005610.66747199
75Salmonella infection_Homo sapiens_hsa051320.66489360
76Prostate cancer_Homo sapiens_hsa052150.66349724
77Arginine biosynthesis_Homo sapiens_hsa002200.65244527
78Carbon metabolism_Homo sapiens_hsa012000.65093519
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.64872777
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64659404
81AMPK signaling pathway_Homo sapiens_hsa041520.63487390
82Glioma_Homo sapiens_hsa052140.63202542
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62166180
84Pentose phosphate pathway_Homo sapiens_hsa000300.62149276
85beta-Alanine metabolism_Homo sapiens_hsa004100.61451132
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60314816
87Renin secretion_Homo sapiens_hsa049240.60196951
88Prion diseases_Homo sapiens_hsa050200.60125508
89Insulin signaling pathway_Homo sapiens_hsa049100.59958825
90Thyroid hormone synthesis_Homo sapiens_hsa049180.59752399
91Tight junction_Homo sapiens_hsa045300.59572833
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59451863
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59377663
94Chronic myeloid leukemia_Homo sapiens_hsa052200.58405447
95Hippo signaling pathway_Homo sapiens_hsa043900.58276831
96Acute myeloid leukemia_Homo sapiens_hsa052210.58152903
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57577464
98Melanoma_Homo sapiens_hsa052180.57257155
99Fatty acid biosynthesis_Homo sapiens_hsa000610.56301693
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56268005
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.55942673
102Endometrial cancer_Homo sapiens_hsa052130.55564045
103Estrogen signaling pathway_Homo sapiens_hsa049150.55524036
104Apoptosis_Homo sapiens_hsa042100.55367886
105Pancreatic cancer_Homo sapiens_hsa052120.53951778
106Renin-angiotensin system_Homo sapiens_hsa046140.53742871
107Rap1 signaling pathway_Homo sapiens_hsa040150.53715175
108Endocytosis_Homo sapiens_hsa041440.53584016
109TGF-beta signaling pathway_Homo sapiens_hsa043500.52519466
110Ras signaling pathway_Homo sapiens_hsa040140.51651870
111HTLV-I infection_Homo sapiens_hsa051660.50791342
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50484937
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50397247
114Lysine degradation_Homo sapiens_hsa003100.50338376
115Osteoclast differentiation_Homo sapiens_hsa043800.49768099
116MAPK signaling pathway_Homo sapiens_hsa040100.49456925
117Oxytocin signaling pathway_Homo sapiens_hsa049210.49240198
118Wnt signaling pathway_Homo sapiens_hsa043100.48760779
119Thyroid cancer_Homo sapiens_hsa052160.48677557
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48374872
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.48076895
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.47971196
123Platelet activation_Homo sapiens_hsa046110.47925710
124HIF-1 signaling pathway_Homo sapiens_hsa040660.47472671
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47368168
126Fat digestion and absorption_Homo sapiens_hsa049750.46879766
127Cocaine addiction_Homo sapiens_hsa050300.46470174
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46206498
129mTOR signaling pathway_Homo sapiens_hsa041500.46094192
130Sulfur metabolism_Homo sapiens_hsa009200.45205661
131Collecting duct acid secretion_Homo sapiens_hsa049660.44810570
132Renal cell carcinoma_Homo sapiens_hsa052110.44313089
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.44045158
134GnRH signaling pathway_Homo sapiens_hsa049120.43717571
135VEGF signaling pathway_Homo sapiens_hsa043700.43696295
136Fructose and mannose metabolism_Homo sapiens_hsa000510.43236122
137Type II diabetes mellitus_Homo sapiens_hsa049300.42682373
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.42194845
139Peroxisome_Homo sapiens_hsa041460.41652247

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