GAS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung epithelium development (GO:0060428)4.37828742
2binding of sperm to zona pellucida (GO:0007339)4.18350450
3cullin deneddylation (GO:0010388)4.00126430
4cilium or flagellum-dependent cell motility (GO:0001539)3.92773102
5sperm-egg recognition (GO:0035036)3.87954599
6establishment of apical/basal cell polarity (GO:0035089)3.82268896
7establishment of integrated proviral latency (GO:0075713)3.64595709
8protein deneddylation (GO:0000338)3.63019333
9axonemal dynein complex assembly (GO:0070286)3.60790186
10microtubule bundle formation (GO:0001578)3.54442910
11epithelial cilium movement (GO:0003351)3.51709600
12primary alcohol catabolic process (GO:0034310)3.50961709
13cilium movement (GO:0003341)3.49357712
14establishment or maintenance of monopolar cell polarity (GO:0061339)3.49200325
15establishment of monopolar cell polarity (GO:0061162)3.49200325
16vitamin transmembrane transport (GO:0035461)3.48464359
17intraciliary transport (GO:0042073)3.37150431
18peptidyl-arginine omega-N-methylation (GO:0035247)3.35569592
19cell-cell recognition (GO:0009988)3.35103231
20negative regulation of microtubule polymerization (GO:0031115)3.33353571
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28719378
22ethanol metabolic process (GO:0006067)3.17816837
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08645476
24protein polyglutamylation (GO:0018095)3.07488885
25semaphorin-plexin signaling pathway (GO:0071526)3.05975152
26desmosome organization (GO:0002934)3.02379675
27left/right axis specification (GO:0070986)3.01864154
28regulation of cholesterol biosynthetic process (GO:0045540)2.98186479
29planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96660462
30establishment of viral latency (GO:0019043)2.94547549
31histone arginine methylation (GO:0034969)2.93374509
32piRNA metabolic process (GO:0034587)2.90415561
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89120600
34protein retention in ER lumen (GO:0006621)2.88793724
35formation of translation preinitiation complex (GO:0001731)2.87590168
36male meiosis (GO:0007140)2.87112532
37positive regulation of smoothened signaling pathway (GO:0045880)2.78113385
38cytoplasmic microtubule organization (GO:0031122)2.78051679
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76594667
40fusion of sperm to egg plasma membrane (GO:0007342)2.75397369
41spliceosomal snRNP assembly (GO:0000387)2.75016011
42de novo posttranslational protein folding (GO:0051084)2.74654058
43sperm capacitation (GO:0048240)2.74645037
44maturation of SSU-rRNA (GO:0030490)2.74608560
45de novo protein folding (GO:0006458)2.74142186
46regulation of cilium movement (GO:0003352)2.73933661
47peptidyl-arginine N-methylation (GO:0035246)2.73192979
48peptidyl-arginine methylation (GO:0018216)2.73192979
49spliceosomal tri-snRNP complex assembly (GO:0000244)2.73139012
50diterpenoid biosynthetic process (GO:0016102)2.69836229
51apical protein localization (GO:0045176)2.69501175
52microtubule severing (GO:0051013)2.69288933
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67006411
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.65865450
55response to pheromone (GO:0019236)2.65352477
56multicellular organism reproduction (GO:0032504)2.64773691
574-hydroxyproline metabolic process (GO:0019471)2.62521738
58left/right pattern formation (GO:0060972)2.61821860
59regulation of microtubule-based movement (GO:0060632)2.60567135
60RNA localization (GO:0006403)2.60082142
61* sperm motility (GO:0030317)2.59149620
62synaptonemal complex organization (GO:0070193)2.58911587
63heterochromatin organization (GO:0070828)2.58880730
64cell-cell junction maintenance (GO:0045217)2.58876124
65acrosome reaction (GO:0007340)2.57050292
66motile cilium assembly (GO:0044458)2.56144554
67proline biosynthetic process (GO:0006561)2.55584245
68synaptonemal complex assembly (GO:0007130)2.54692576
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54586846
70regulation of NFAT protein import into nucleus (GO:0051532)2.52315844
71protein localization to cilium (GO:0061512)2.51213414
72negative regulation of cell size (GO:0045792)2.49781815
73mating behavior (GO:0007617)2.49608357
74glomerular epithelial cell development (GO:0072310)2.49578975
75ventricular system development (GO:0021591)2.49220956
76ear development (GO:0043583)2.46402746
77protein insertion into membrane (GO:0051205)2.45480820
78acrosome assembly (GO:0001675)2.45018077
79synaptic vesicle docking involved in exocytosis (GO:0016081)2.42879671
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.42614120
81histone H2A acetylation (GO:0043968)2.38872800
82peptidyl-lysine dimethylation (GO:0018027)2.38448383
83regulation of protein heterodimerization activity (GO:0043497)2.36147705
84regulation of centriole replication (GO:0046599)2.35916196
85asymmetric protein localization (GO:0008105)2.35345461
86regulation of cholesterol metabolic process (GO:0090181)2.34655611
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.33834435
88negative regulation of ligase activity (GO:0051352)2.33834435
89spliceosomal complex assembly (GO:0000245)2.33259952
90mRNA splicing, via spliceosome (GO:0000398)2.32306727
91RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.32306727
92cerebellar granule cell differentiation (GO:0021707)2.30334245
93blastocyst development (GO:0001824)2.30306888
94stress granule assembly (GO:0034063)2.29389742
95nucleobase biosynthetic process (GO:0046112)2.28477156
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.28276554
97negative regulation of RNA splicing (GO:0033119)2.27547399
98DNA unwinding involved in DNA replication (GO:0006268)2.27442534
99multicellular organismal water homeostasis (GO:0050891)2.26853985
100RNA splicing, via transesterification reactions (GO:0000375)2.26744694
101regulation of microtubule depolymerization (GO:0031114)2.25895744
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.25064138
103establishment or maintenance of bipolar cell polarity (GO:0061245)2.23892580
104establishment or maintenance of apical/basal cell polarity (GO:0035088)2.23892580
1057-methylguanosine mRNA capping (GO:0006370)2.22945406
106microtubule depolymerization (GO:0007019)2.22820665
107cell junction maintenance (GO:0034331)2.22215192
108embryonic camera-type eye development (GO:0031076)2.22178315
109cellular component assembly involved in morphogenesis (GO:0010927)2.21942375
110chondrocyte proliferation (GO:0035988)2.21751018
111termination of RNA polymerase II transcription (GO:0006369)2.21364826
112establishment of planar polarity (GO:0001736)2.21278532
113establishment of tissue polarity (GO:0007164)2.21278532
114body morphogenesis (GO:0010171)2.21038206
115ethanol oxidation (GO:0006069)2.20295413
116COPI coating of Golgi vesicle (GO:0048205)2.19636785
117Golgi transport vesicle coating (GO:0048200)2.19636785
118layer formation in cerebral cortex (GO:0021819)2.18785306
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.18418787
120mitotic spindle organization (GO:0007052)2.17743731
121response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.17209090
122plasma membrane fusion (GO:0045026)2.16479908
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.16254029
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.16254029
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.16254029
126embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15220033
127nucleotide-excision repair, DNA gap filling (GO:0006297)2.14941570
128glutathione biosynthetic process (GO:0006750)2.14492304
129cilium organization (GO:0044782)2.14365563
130proline metabolic process (GO:0006560)2.13626470
131neuronal ion channel clustering (GO:0045161)2.13615386
132single fertilization (GO:0007338)2.13061274
133DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.12935860
134cell migration in hindbrain (GO:0021535)2.12564055
135protein localization to chromosome, centromeric region (GO:0071459)2.12551750
1367-methylguanosine RNA capping (GO:0009452)2.11788911
137RNA capping (GO:0036260)2.11788911
138cilium assembly (GO:0042384)2.11467630
139DNA replication-dependent nucleosome organization (GO:0034723)2.10953023
140DNA replication-dependent nucleosome assembly (GO:0006335)2.10953023
141regulation of interleukin-5 production (GO:0032674)2.10543077
142axoneme assembly (GO:0035082)2.10150229
143negative regulation of microtubule depolymerization (GO:0007026)2.09861397
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.09826284
145negative regulation of DNA repair (GO:0045738)2.09542909
146monoubiquitinated protein deubiquitination (GO:0035520)2.09423728
147regulation of establishment of planar polarity (GO:0090175)2.09012202
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.08935270
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.08935270
150intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.08923166
151signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.08923166
152endothelial cell chemotaxis (GO:0035767)2.08815218
153microtubule-based movement (GO:0007018)2.07594108
154protein-DNA complex disassembly (GO:0032986)2.07479497
155nucleosome disassembly (GO:0006337)2.07479497
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.07392409
157regulation of interleukin-13 production (GO:0032656)2.07119834
158positive regulation of gastrulation (GO:2000543)2.06550894
159mRNA splice site selection (GO:0006376)2.06463603
160camera-type eye morphogenesis (GO:0048593)2.06353610
161signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.06205398
162signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.06205398
163signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.06205398
164cell projection assembly (GO:0030031)2.05086427
165muscle cell migration (GO:0014812)2.04115128
166positive regulation of synapse maturation (GO:0090129)2.04000189
167adherens junction assembly (GO:0034333)2.03067516
168negative regulation of catenin import into nucleus (GO:0035414)2.01944980
169positive regulation of protein targeting to membrane (GO:0090314)2.01702546
170epithelial cell-cell adhesion (GO:0090136)2.00669577
171GDP-mannose metabolic process (GO:0019673)1.98315052
172negative regulation of T cell differentiation in thymus (GO:0033085)1.97377120
173focal adhesion assembly (GO:0048041)1.95954748
174cell-substrate adherens junction assembly (GO:0007045)1.95954748
175nonribosomal peptide biosynthetic process (GO:0019184)1.95897321
176phosphate ion transmembrane transport (GO:0035435)1.94905139
177cell volume homeostasis (GO:0006884)1.94218110
178one-carbon compound transport (GO:0019755)1.94091296
179sodium ion homeostasis (GO:0055078)1.92948357
180maternal placenta development (GO:0001893)1.92257568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.86572615
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.51305102
3E2F7_22180533_ChIP-Seq_HELA_Human3.83000651
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.29304659
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21073818
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.01116230
7ZNF263_19887448_ChIP-Seq_K562_Human2.75930594
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.63966173
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.63224919
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.59987830
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52643998
12RACK7_27058665_Chip-Seq_MCF-7_Human2.50153235
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49722622
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.47515320
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42014356
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.40162614
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.35897990
18* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32307423
19LXR_22292898_ChIP-Seq_THP-1_Human2.29660629
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29529940
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.28129090
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22206210
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.19419388
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.19154551
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16335897
26EZH2_22144423_ChIP-Seq_EOC_Human2.13271772
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13030824
28XRN2_22483619_ChIP-Seq_HELA_Human2.06937498
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06860620
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03735532
31SMC4_20622854_ChIP-Seq_HELA_Human2.01776390
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01072130
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94763718
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.91952091
35DROSHA_22980978_ChIP-Seq_HELA_Human1.90481340
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88147288
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87855910
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87744766
39P68_20966046_ChIP-Seq_HELA_Human1.85985641
40GABP_19822575_ChIP-Seq_HepG2_Human1.84807237
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.83871320
42TTF2_22483619_ChIP-Seq_HELA_Human1.79581738
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.78521553
44SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.77430496
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77170166
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75774413
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75413782
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75027479
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74566794
50CREB1_26743006_Chip-Seq_LNCaP_Human1.73306097
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73263113
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68322244
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67688672
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63691803
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59556372
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59045401
57ZNF274_21170338_ChIP-Seq_K562_Hela1.58255040
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57548977
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57227195
60KDM2B_26808549_Chip-Seq_K562_Human1.56943551
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55904505
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55221929
63DCP1A_22483619_ChIP-Seq_HELA_Human1.55199562
64CTCF_27219007_Chip-Seq_Bcells_Human1.53761594
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53202394
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51296606
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49231430
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.48825787
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.47876852
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47666483
71CLOCK_20551151_ChIP-Seq_293T_Human1.46100633
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45872125
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.45393252
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43810401
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43537131
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42561304
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.41931801
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41747733
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.40856275
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39743042
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36857383
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.35756808
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35568003
84* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35158805
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34631691
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32876020
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32871564
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31822980
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31659248
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29276530
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29137151
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29135076
93VDR_23849224_ChIP-Seq_CD4+_Human1.28544270
94FOXP3_21729870_ChIP-Seq_TREG_Human1.28496267
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.28469719
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28298658
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28036475
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27125072
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.26966458
100RARB_27405468_Chip-Seq_BRAIN_Mouse1.25765097
101TP63_22573176_ChIP-Seq_HFKS_Human1.25303889
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.25105228
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24389321
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23134931
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.22764592
106* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22555995
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19898674
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19704095
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.19548766
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18040782
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17433994
112ELK1_19687146_ChIP-ChIP_HELA_Human1.17324335
113GATA1_26923725_Chip-Seq_HPCs_Mouse1.17189775
114* EZH2_27294783_Chip-Seq_ESCs_Mouse1.17053286
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14142651
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13631696
117ATF3_27146783_Chip-Seq_COLON_Human1.13494948
118PHF8_20622854_ChIP-Seq_HELA_Human1.13244577
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.13025078
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12134585
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09354547
122CIITA_25753668_ChIP-Seq_RAJI_Human1.08830206
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06351495
124STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05946980
125* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05827037
126RNF2_27304074_Chip-Seq_NSC_Mouse1.01978923
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01812699
128AR_21909140_ChIP-Seq_LNCAP_Human1.01373509
129KLF5_25053715_ChIP-Seq_YYC3_Human1.01056212
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00585056
131CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00508181
132* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99192605
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99032153
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98552461
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98122744
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98047985
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98029469
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97202415
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96945762
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96850622
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96843720
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96513874
143CTCF_20526341_ChIP-Seq_ESCs_Human0.96339597
144E2F1_21310950_ChIP-Seq_MCF-7_Human0.96165287
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95643394
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.95257799
147RXR_22158963_ChIP-Seq_LIVER_Mouse0.95147751
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94045442
149BCOR_27268052_Chip-Seq_Bcells_Human0.93552641
150KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93507850
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93188238
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92826112
153MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92789360
154ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92626937
155AHR_22903824_ChIP-Seq_MCF-7_Human0.92413810
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.90967173
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.89800618
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88283746
159TP53_22127205_ChIP-Seq_IMR90_Human0.87850911
160FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87476442
161CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86023322
162REST_21632747_ChIP-Seq_MESCs_Mouse0.85112307
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84780412
164SOX3_22085726_ChIP-Seq_NPCs_Mouse0.84185240
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.83074333
166* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82117345
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.82040208
168TFEB_21752829_ChIP-Seq_HELA_Human0.81916868
169* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81806683
170SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81509788
171KDM5A_27292631_Chip-Seq_BREAST_Human0.81153670
172TP53_23651856_ChIP-Seq_MEFs_Mouse0.80147422
173FOXP1_21924763_ChIP-Seq_HESCs_Human0.79459606
174NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78100042
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78070724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.07466252
2MP0000566_synostosis2.89902585
3MP0008875_abnormal_xenobiotic_pharmacok2.72532292
4MP0002653_abnormal_ependyma_morphology2.64527635
5MP0010030_abnormal_orbit_morphology2.62148680
6MP0004043_abnormal_pH_regulation2.47536456
7MP0005410_abnormal_fertilization2.40376664
8MP0005623_abnormal_meninges_morphology2.38769314
9MP0003283_abnormal_digestive_organ2.37088470
10MP0010234_abnormal_vibrissa_follicle2.32445020
11MP0003122_maternal_imprinting2.26930455
12MP0000678_abnormal_parathyroid_gland2.20762147
13MP0002249_abnormal_larynx_morphology2.13799517
14MP0008877_abnormal_DNA_methylation2.08075579
15MP0000751_myopathy2.05155535
16MP0002282_abnormal_trachea_morphology2.03046385
17MP0000569_abnormal_digit_pigmentation2.01365196
18MP0005409_darkened_coat_color2.00497927
19MP0003121_genomic_imprinting1.86176908
20MP0008932_abnormal_embryonic_tissue1.80123790
21MP0008007_abnormal_cellular_replicative1.77300956
22MP0003942_abnormal_urinary_system1.75936698
23MP0002751_abnormal_autonomic_nervous1.75344565
24MP0005171_absent_coat_pigmentation1.73035864
25MP0000778_abnormal_nervous_system1.68927337
26MP0003136_yellow_coat_color1.68536864
27MP0010094_abnormal_chromosome_stability1.66411895
28MP0003077_abnormal_cell_cycle1.65765549
29MP0004133_heterotaxia1.65566877
30MP0003705_abnormal_hypodermis_morpholog1.65501425
31MP0003123_paternal_imprinting1.62856653
32MP0001849_ear_inflammation1.60578786
33MP0002102_abnormal_ear_morphology1.59275974
34MP0004859_abnormal_synaptic_plasticity1.59235043
35MP0003111_abnormal_nucleus_morphology1.58440273
36MP0002234_abnormal_pharynx_morphology1.57872459
37MP0005408_hypopigmentation1.56071788
38MP0004233_abnormal_muscle_weight1.54099752
39MP0006292_abnormal_olfactory_placode1.52807885
40MP0004957_abnormal_blastocyst_morpholog1.50721669
41MP0003693_abnormal_embryo_hatching1.50321038
42MP0004858_abnormal_nervous_system1.47735240
43MP0000003_abnormal_adipose_tissue1.47702005
44MP0001986_abnormal_taste_sensitivity1.47577454
45MP0003890_abnormal_embryonic-extraembry1.43545815
46MP0003385_abnormal_body_wall1.43024479
47MP0008058_abnormal_DNA_repair1.42545155
48MP0000534_abnormal_ureter_morphology1.41926525
49MP0002909_abnormal_adrenal_gland1.40403791
50MP0003119_abnormal_digestive_system1.39852961
51MP0005423_abnormal_somatic_nervous1.36183071
52MP0005083_abnormal_biliary_tract1.36113560
53MP0002822_catalepsy1.35156277
54MP0002184_abnormal_innervation1.33585653
55MP0000049_abnormal_middle_ear1.33528437
56MP0001730_embryonic_growth_arrest1.33378181
57MP0009250_abnormal_appendicular_skeleto1.33067036
58MP0006072_abnormal_retinal_apoptosis1.33031228
59MP0003698_abnormal_male_reproductive1.30270144
60MP0005257_abnormal_intraocular_pressure1.29142940
61MP0000013_abnormal_adipose_tissue1.28566518
62MP0001929_abnormal_gametogenesis1.27962375
63MP0009053_abnormal_anal_canal1.26689677
64MP0005248_abnormal_Harderian_gland1.26430374
65MP0010352_gastrointestinal_tract_polyps1.24961311
66MP0003861_abnormal_nervous_system1.24780908
67MP0003755_abnormal_palate_morphology1.23893862
68MP0008789_abnormal_olfactory_epithelium1.20699935
69MP0000537_abnormal_urethra_morphology1.19722134
70MP0002116_abnormal_craniofacial_bone1.19168665
71MP0002084_abnormal_developmental_patter1.18699906
72MP0001984_abnormal_olfaction1.16901497
73MP0002210_abnormal_sex_determination1.16563060
74MP0002734_abnormal_mechanical_nocicepti1.16372154
75MP0002160_abnormal_reproductive_system1.16310875
76MP0003937_abnormal_limbs/digits/tail_de1.15860682
77MP0000350_abnormal_cell_proliferation1.14726821
78MP0000428_abnormal_craniofacial_morphol1.14550076
79MP0001348_abnormal_lacrimal_gland1.13484778
80MP0002085_abnormal_embryonic_tissue1.12149661
81MP0001346_abnormal_lacrimal_gland1.11803717
82MP0002736_abnormal_nociception_after1.10590344
83MP0006276_abnormal_autonomic_nervous1.10133679
84MP0003115_abnormal_respiratory_system1.09996000
85MP0005499_abnormal_olfactory_system1.08633612
86MP0005394_taste/olfaction_phenotype1.08633612
87MP0002932_abnormal_joint_morphology1.08207169
88MP0010678_abnormal_skin_adnexa1.07758455
89MP0005503_abnormal_tendon_morphology1.06097063
90MP0005058_abnormal_lysosome_morphology1.05830826
91MP0000747_muscle_weakness1.05813555
92MP0001502_abnormal_circadian_rhythm1.05651975
93MP0004811_abnormal_neuron_physiology1.03731579
94MP0002132_abnormal_respiratory_system1.03698020
95MP0000383_abnormal_hair_follicle1.03309864
96MP0001697_abnormal_embryo_size1.03049210
97MP0004264_abnormal_extraembryonic_tissu1.02919086
98MP0002233_abnormal_nose_morphology1.02329272
99MP0010386_abnormal_urinary_bladder1.00912168
100MP0000467_abnormal_esophagus_morphology1.00768978
101MP0000579_abnormal_nail_morphology0.99156864
102MP0003787_abnormal_imprinting0.99095148
103MP0000681_abnormal_thyroid_gland0.97442617
104MP0002089_abnormal_postnatal_growth/wei0.96343897
105MP0001968_abnormal_touch/_nociception0.96201562
106MP0002928_abnormal_bile_duct0.95943719
107MP0005508_abnormal_skeleton_morphology0.93802347
108MP0003879_abnormal_hair_cell0.93528411
109MP0004270_analgesia0.93483409
110MP0000733_abnormal_muscle_development0.93185070
111MP0001529_abnormal_vocalization0.92253137
112MP0005380_embryogenesis_phenotype0.91711074
113MP0001672_abnormal_embryogenesis/_devel0.91711074
114MP0001145_abnormal_male_reproductive0.90960209
115MP0005330_cardiomyopathy0.90661995
116MP0004272_abnormal_basement_membrane0.90472647
117MP0004197_abnormal_fetal_growth/weight/0.90079592
118MP0002796_impaired_skin_barrier0.89816493
119MP0002735_abnormal_chemical_nociception0.89566596
120MP0000955_abnormal_spinal_cord0.88867017
121MP0003878_abnormal_ear_physiology0.87603702
122MP0005377_hearing/vestibular/ear_phenot0.87603702
123MP0001299_abnormal_eye_distance/0.87533100
124MP0002269_muscular_atrophy0.87492030
125MP0002108_abnormal_muscle_morphology0.87180173
126MP0004134_abnormal_chest_morphology0.86498299
127MP0000759_abnormal_skeletal_muscle0.86077780
128MP0002161_abnormal_fertility/fecundity0.85912923
129MP0000749_muscle_degeneration0.85617426
130MP0002114_abnormal_axial_skeleton0.84982659
131MP0002877_abnormal_melanocyte_morpholog0.84707143
132MP0002152_abnormal_brain_morphology0.84532031
133MP0002080_prenatal_lethality0.83809986
134MP0003315_abnormal_perineum_morphology0.83570620
135MP0003091_abnormal_cell_migration0.83510910
136MP0003935_abnormal_craniofacial_develop0.83498671
137MP0004087_abnormal_muscle_fiber0.83453450
138MP0000631_abnormal_neuroendocrine_gland0.83177911
139MP0008260_abnormal_autophagy0.82843265
140MP0005375_adipose_tissue_phenotype0.82803160
141MP0003984_embryonic_growth_retardation0.82163208
142MP0002081_perinatal_lethality0.81719397
143MP0002088_abnormal_embryonic_growth/wei0.80751264
144MP0005076_abnormal_cell_differentiation0.80647804
145MP0002098_abnormal_vibrissa_morphology0.80261781
146MP0008438_abnormal_cutaneous_collagen0.79234121
147MP0000358_abnormal_cell_content/0.79211284
148MP0005501_abnormal_skin_physiology0.78940654
149MP0004185_abnormal_adipocyte_glucose0.76386586
150MP0002896_abnormal_bone_mineralization0.75704252
151MP0006138_congestive_heart_failure0.75219925
152MP0005670_abnormal_white_adipose0.74251737
153MP0001270_distended_abdomen0.72232463
154MP0003634_abnormal_glial_cell0.71894817
155MP0001765_abnormal_ion_homeostasis0.71389973
156MP0002168_other_aberrant_phenotype0.71100568
157MP0004782_abnormal_surfactant_physiolog0.70513517
158MP0000026_abnormal_inner_ear0.69673936
159MP0000762_abnormal_tongue_morphology0.69354488
160MP0002557_abnormal_social/conspecific_i0.69194092
161MP0003566_abnormal_cell_adhesion0.68926616
162MP0009703_decreased_birth_body0.68190469
163MP0005646_abnormal_pituitary_gland0.67858905
164MP0002092_abnormal_eye_morphology0.67344736
165MP0002882_abnormal_neuron_morphology0.67134122
166MP0003635_abnormal_synaptic_transmissio0.65664286
167MP0003938_abnormal_ear_development0.65580560

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.90339243
2Bronchiectasis (HP:0002110)4.48101035
3Nasal polyposis (HP:0100582)4.32992068
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.00154814
5Absent/shortened dynein arms (HP:0200106)4.00154814
6Abnormal respiratory motile cilium physiology (HP:0012261)3.85923472
7Atelectasis (HP:0100750)3.78406556
8Abnormal respiratory motile cilium morphology (HP:0005938)3.56749227
9Abnormal respiratory epithelium morphology (HP:0012253)3.56749227
10Abnormality of the nasal mucosa (HP:0000433)3.55355238
11Abnormal ciliary motility (HP:0012262)3.44893350
12Male infertility (HP:0003251)3.44838237
13Abnormality of dentin (HP:0010299)3.32036493
14Rhinitis (HP:0012384)3.22934063
15Bell-shaped thorax (HP:0001591)2.95467393
16Chronic bronchitis (HP:0004469)2.79943479
17Protrusio acetabuli (HP:0003179)2.76774224
18Nephronophthisis (HP:0000090)2.73199169
19Selective tooth agenesis (HP:0001592)2.69344576
20Obstructive sleep apnea (HP:0002870)2.64064829
21Trismus (HP:0000211)2.54904168
22Recurrent otitis media (HP:0000403)2.53350793
23Facial cleft (HP:0002006)2.52262593
24Trigonocephaly (HP:0000243)2.46194359
25Abnormality of the lower motor neuron (HP:0002366)2.42726657
26Hypoplasia of the pons (HP:0012110)2.35204460
27Fibular hypoplasia (HP:0003038)2.32058448
28Degeneration of anterior horn cells (HP:0002398)2.30668748
29Abnormality of the anterior horn cell (HP:0006802)2.30668748
30Distal lower limb muscle weakness (HP:0009053)2.28593536
31Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23537526
32Aplasia/Hypoplasia of the fibula (HP:0006492)2.22803852
33Glossoptosis (HP:0000162)2.19634082
34Aplasia/Hypoplasia of the sternum (HP:0006714)2.16532471
35Nuclear cataract (HP:0100018)2.15701949
36Molar tooth sign on MRI (HP:0002419)2.15125778
37Abnormality of midbrain morphology (HP:0002418)2.15125778
38Flat acetabular roof (HP:0003180)2.13702454
39Hyperacusis (HP:0010780)2.11490084
40Asymmetry of the thorax (HP:0001555)2.09518081
41Bronchitis (HP:0012387)2.08217758
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06194709
43Short 4th metacarpal (HP:0010044)2.06194709
44Pancreatic fibrosis (HP:0100732)2.05820193
45Fibular aplasia (HP:0002990)2.02921359
46Premature rupture of membranes (HP:0001788)2.02337886
47Abnormal number of incisors (HP:0011064)1.99663169
48Preaxial hand polydactyly (HP:0001177)1.98749005
49Hand muscle atrophy (HP:0009130)1.98746873
50Renal duplication (HP:0000075)1.98402917
51Stridor (HP:0010307)1.98054973
52Short nail (HP:0001799)1.97886070
53Absent epiphyses (HP:0010577)1.95645120
54Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95645120
55Short ribs (HP:0000773)1.95214112
56Hyperactive renin-angiotensin system (HP:0000841)1.94718912
57Deviation of the thumb (HP:0009603)1.93906559
58J-shaped sella turcica (HP:0002680)1.93861214
59Patellar aplasia (HP:0006443)1.93842868
60Wrist flexion contracture (HP:0001239)1.91748691
61Spinal cord compression (HP:0002176)1.91674098
62Abnormality of the renal medulla (HP:0100957)1.91579904
63Increased density of long bones (HP:0006392)1.90543732
64True hermaphroditism (HP:0010459)1.89248606
65Proximal placement of thumb (HP:0009623)1.88788887
66Chronic sinusitis (HP:0011109)1.88157359
67Abnormality of the pons (HP:0007361)1.86716558
68Bifid tongue (HP:0010297)1.85813313
69Medial flaring of the eyebrow (HP:0010747)1.84614557
70Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83065852
71Hypoplasia of the brainstem (HP:0002365)1.83065852
7211 pairs of ribs (HP:0000878)1.80736165
73Bronchomalacia (HP:0002780)1.80702595
74Bowel diverticulosis (HP:0005222)1.80401621
75Cervical subluxation (HP:0003308)1.79750662
76Mildly elevated creatine phosphokinase (HP:0008180)1.79477714
77Aplasia/Hypoplasia of the patella (HP:0006498)1.77563407
78Shallow orbits (HP:0000586)1.77327391
79Gastrointestinal atresia (HP:0002589)1.77229854
80Neonatal short-limb short stature (HP:0008921)1.76871821
81Chronic hepatic failure (HP:0100626)1.76686486
82Lissencephaly (HP:0001339)1.76426524
83Esophageal atresia (HP:0002032)1.76055504
84Vertebral compression fractures (HP:0002953)1.75593365
85Heterochromia iridis (HP:0001100)1.73756391
86Vertebral arch anomaly (HP:0008438)1.73334305
87Postaxial hand polydactyly (HP:0001162)1.72906177
88Abnormality of the distal phalanges of the toes (HP:0010182)1.72029631
89Gait imbalance (HP:0002141)1.71349289
90Exercise-induced myalgia (HP:0003738)1.71152109
91Recurrent sinusitis (HP:0011108)1.70341567
92Renal salt wasting (HP:0000127)1.68464280
93Spinal muscular atrophy (HP:0007269)1.67418567
94Atresia of the external auditory canal (HP:0000413)1.67333411
95Postaxial foot polydactyly (HP:0001830)1.66791038
96Pancreatic cysts (HP:0001737)1.65795652
97Aplasia/Hypoplasia of the lens (HP:0008063)1.61613760
98Increased nuchal translucency (HP:0010880)1.61225062
99Congenital primary aphakia (HP:0007707)1.60652355
100Hypoventilation (HP:0002791)1.59884050
101Distal upper limb amyotrophy (HP:0007149)1.59731203
102Upper limb amyotrophy (HP:0009129)1.59731203
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.59489370
104Slender long bone (HP:0003100)1.59214377
105Short thorax (HP:0010306)1.59033902
106Abnormality of the aortic arch (HP:0012303)1.58866518
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.58678619
108Oculomotor apraxia (HP:0000657)1.58534298
109Abnormality of permanent molar morphology (HP:0011071)1.57591862
110Abnormality of the dental root (HP:0006486)1.57591862
111Taurodontia (HP:0000679)1.57591862
112Lip pit (HP:0100267)1.55934855
113Intestinal atresia (HP:0011100)1.54812350
114Fetal akinesia sequence (HP:0001989)1.54323926
115Shoulder girdle muscle weakness (HP:0003547)1.52702257
116Ulnar bowing (HP:0003031)1.52647660
117Polycystic kidney dysplasia (HP:0000113)1.52319647
118Bladder diverticulum (HP:0000015)1.51467582
119Tubulointerstitial nephritis (HP:0001970)1.51460324
120Occipital encephalocele (HP:0002085)1.51196372
121Distal lower limb amyotrophy (HP:0008944)1.49880690
122Sleep apnea (HP:0010535)1.48317995
123Cystic liver disease (HP:0006706)1.48146322
124Advanced eruption of teeth (HP:0006288)1.48038655
125Alacrima (HP:0000522)1.47056607
126Long toe (HP:0010511)1.46526144
127Abnormality of the labia minora (HP:0012880)1.45578165
128Aplasia/hypoplasia of the humerus (HP:0006507)1.45362891
129Missing ribs (HP:0000921)1.45345621
130Deep venous thrombosis (HP:0002625)1.44275751
131Optic nerve coloboma (HP:0000588)1.44151785
132Stage 5 chronic kidney disease (HP:0003774)1.44057695
133Difficulty climbing stairs (HP:0003551)1.43860474
134Right ventricular cardiomyopathy (HP:0011663)1.43346977
135Abnormality of molar (HP:0011077)1.42445097
136Abnormality of molar morphology (HP:0011070)1.42445097
137Buphthalmos (HP:0000557)1.42291804
138Hepatoblastoma (HP:0002884)1.42059781
139Infertility (HP:0000789)1.41368888
140Pointed chin (HP:0000307)1.41005883
141Supernumerary spleens (HP:0009799)1.40494600
142Broad distal phalanx of finger (HP:0009836)1.40283429
143Long palpebral fissure (HP:0000637)1.39591458
144Amblyopia (HP:0000646)1.39550624
145Hyperkalemia (HP:0002153)1.39021384
146Self-mutilation (HP:0000742)1.38315503
147Broad face (HP:0000283)1.37916087
148Flattened epiphyses (HP:0003071)1.37668937
149Bifid scrotum (HP:0000048)1.35966574
150Diaphragmatic weakness (HP:0009113)1.35603369
151Vascular calcification (HP:0004934)1.34653096
152Bundle branch block (HP:0011710)1.34120606
153Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.33482705
154Cholecystitis (HP:0001082)1.33285069
155Abnormal gallbladder physiology (HP:0012438)1.33285069
156Narrow chest (HP:0000774)1.32811961
157Abnormality of the dental pulp (HP:0006479)1.32553121
158Congenital hepatic fibrosis (HP:0002612)1.32552183
159Back pain (HP:0003418)1.27334779
160Hyperthyroidism (HP:0000836)1.26448188
161Aplasia of the musculature (HP:0100854)1.26015944
162Aplasia involving bones of the upper limbs (HP:0009823)1.25705795
163Aplasia of the phalanges of the hand (HP:0009802)1.25705795
164Aplasia involving bones of the extremities (HP:0009825)1.25705795
165Ankle clonus (HP:0011448)1.25480580
166Abnormality of the musculature of the hand (HP:0001421)1.24494216
167Foot dorsiflexor weakness (HP:0009027)1.22895771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.90611962
2EEF2K3.90702621
3BUB13.52959971
4TESK13.33030113
5SIK13.02456950
6MAPKAPK32.63288527
7MST1R2.47652135
8MARK12.31555059
9ERBB32.29379216
10PASK2.28635272
11PDK32.13054855
12PDK42.13054855
13SMG12.08064439
14SIK21.95378702
15CDC71.94904280
16PNCK1.90359436
17RIPK11.86049064
18LIMK11.81744830
19MAPKAPK51.79785868
20PRKD31.78360148
21STK161.75794591
22NME11.69193749
23PKN21.67264475
24LATS11.66825623
25PAK41.63135458
26TGFBR11.62399443
27MINK11.61770997
28DYRK21.60900229
29MKNK11.60339519
30BMPR1B1.59940139
31FGFR41.55850380
32KSR11.53063032
33TESK21.49771402
34LATS21.48742345
35MET1.47525737
36PIM21.47317479
37MAPK131.45459663
38MAP3K41.43816402
39CDK121.40942357
40ARAF1.37916971
41EPHA41.37817082
42RPS6KB21.36616291
43MUSK1.35330294
44MARK21.34427086
45TSSK61.33830008
46SRPK11.27896426
47TLK11.27745851
48TRPM71.19067893
49LMTK21.18794811
50SIK31.18224558
51NTRK11.17070089
52NTRK31.15665909
53PRKCI1.13456171
54WEE11.13314524
55MST41.08312681
56CHEK21.08034348
57BRAF1.06112368
58ILK1.05683880
59PTK2B1.05559563
60PLK31.04606730
61EPHB11.03341935
62AURKA1.02994103
63PHKG11.02614569
64PHKG21.02614569
65MAP3K101.01067369
66NEK60.99886601
67DAPK10.99703385
68EIF2AK10.99364087
69TTN0.99124509
70NME20.98936237
71PLK10.97703276
72CDK180.96708549
73RPS6KA20.96155539
74ICK0.96084665
75BRSK10.96062068
76CDK80.95401092
77EPHB20.95321758
78DDR20.95217636
79DYRK1B0.95045543
80LRRK20.93485735
81PTK20.91143208
82DYRK30.89722446
83CDK140.89348501
84ACVR1B0.88955216
85CDK150.86353661
86UHMK10.85869249
87BCR0.84871153
88PDGFRA0.83717846
89CHEK10.83225600
90CDK11A0.83047077
91TRIB30.83010432
92STK380.82893622
93PAK30.80855944
94NEK10.79173020
95MAP2K70.77281215
96MAP3K70.76677204
97MAP3K90.76128454
98AKT20.74462587
99ATR0.74190237
100PTK60.72376120
101NTRK20.71721525
102TTK0.71133545
103PAK10.71036294
104CAMK2G0.70706479
105PDPK10.69968913
106SCYL20.67909742
107TAOK20.67436628
108CDK70.67403809
109PBK0.66979848
110MTOR0.66429174
111MAP3K30.64606344
112MAP3K120.63241306
113PDK20.62899909
114EPHA20.61395759
115ERBB20.59698872
116NEK20.59528628
117CDK30.58841705
118ERBB40.58420420
119MAP2K40.58207739
120RAF10.58159194
121PAK60.58153578
122IRAK30.57949594
123PLK20.57017317
124AURKB0.55161649
125MAP3K60.55036880
126WNK40.54961918
127CDC42BPA0.54145887
128PAK20.54056055
129PRKAA10.53479667
130PRKD20.53459514
131BCKDK0.52000390
132CASK0.50216350
133MAP2K20.49679424
134CAMK2B0.48430163
135BMX0.45791454
136BRSK20.44885563
137PRKAA20.43845952
138FER0.43744857
139PRKCG0.43505742
140RET0.42760115
141CAMK1G0.42502990
142ERN10.42095518
143CDK10.41564355
144CDK20.39844118
145MAPK100.39613912
146STK38L0.38762456
147ROCK10.38402583
148GRK50.37964936
149MAP2K10.37625283
150DAPK30.37164920
151CCNB10.36353985
152MAP3K20.34911439
153CAMKK10.34736144
154PRKD10.34289225
155FGFR20.33759928
156MAP3K110.33521536
157STK240.32771475
158CSNK1E0.31934918
159FGFR30.31821957

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.24482449
2Spliceosome_Homo sapiens_hsa030402.59950509
3Proteasome_Homo sapiens_hsa030502.58688229
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.33491226
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.31758875
6Tyrosine metabolism_Homo sapiens_hsa003502.20195898
7RNA polymerase_Homo sapiens_hsa030202.17723959
8RNA transport_Homo sapiens_hsa030132.17651244
9DNA replication_Homo sapiens_hsa030302.07684220
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00501193
11Cell cycle_Homo sapiens_hsa041101.92652780
12Mismatch repair_Homo sapiens_hsa034301.91252545
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87519659
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87441455
15Base excision repair_Homo sapiens_hsa034101.85219789
16Histidine metabolism_Homo sapiens_hsa003401.80592912
17Ribosome_Homo sapiens_hsa030101.77329596
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73605288
19mRNA surveillance pathway_Homo sapiens_hsa030151.68558189
20Fructose and mannose metabolism_Homo sapiens_hsa000511.67889678
21Nucleotide excision repair_Homo sapiens_hsa034201.59078128
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57728630
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57100482
24Pyrimidine metabolism_Homo sapiens_hsa002401.48829373
25Hedgehog signaling pathway_Homo sapiens_hsa043401.47517809
26Basal cell carcinoma_Homo sapiens_hsa052171.44516605
27Biosynthesis of amino acids_Homo sapiens_hsa012301.38938433
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38422349
29Chemical carcinogenesis_Homo sapiens_hsa052041.37165568
30Oocyte meiosis_Homo sapiens_hsa041141.34134224
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32987919
32Synaptic vesicle cycle_Homo sapiens_hsa047211.32433546
33Phototransduction_Homo sapiens_hsa047441.32162808
34Notch signaling pathway_Homo sapiens_hsa043301.30731937
35Vibrio cholerae infection_Homo sapiens_hsa051101.29250487
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26628127
37Hippo signaling pathway_Homo sapiens_hsa043901.26327585
38Arginine biosynthesis_Homo sapiens_hsa002201.26199107
39Huntingtons disease_Homo sapiens_hsa050161.24800530
40beta-Alanine metabolism_Homo sapiens_hsa004101.24443357
41Pyruvate metabolism_Homo sapiens_hsa006201.21316192
42Basal transcription factors_Homo sapiens_hsa030221.20713783
43Lysine degradation_Homo sapiens_hsa003101.20126198
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18507118
45RNA degradation_Homo sapiens_hsa030181.16856284
46Arginine and proline metabolism_Homo sapiens_hsa003301.15284848
47Bladder cancer_Homo sapiens_hsa052191.14782568
48Epstein-Barr virus infection_Homo sapiens_hsa051691.13571507
49Glutathione metabolism_Homo sapiens_hsa004801.10834893
50Non-homologous end-joining_Homo sapiens_hsa034501.09778175
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09087923
52Purine metabolism_Homo sapiens_hsa002301.08073202
53Cocaine addiction_Homo sapiens_hsa050301.07755206
54ABC transporters_Homo sapiens_hsa020101.04547216
55Homologous recombination_Homo sapiens_hsa034401.04055822
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02843300
57Colorectal cancer_Homo sapiens_hsa052101.01035435
58Olfactory transduction_Homo sapiens_hsa047400.99422721
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99307701
60Carbon metabolism_Homo sapiens_hsa012000.98926648
61Collecting duct acid secretion_Homo sapiens_hsa049660.98152920
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97756755
63Vitamin B6 metabolism_Homo sapiens_hsa007500.96734631
64Fanconi anemia pathway_Homo sapiens_hsa034600.94553022
65Glucagon signaling pathway_Homo sapiens_hsa049220.94366041
66AMPK signaling pathway_Homo sapiens_hsa041520.94048532
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92850251
68Wnt signaling pathway_Homo sapiens_hsa043100.91248162
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91190792
70Sulfur relay system_Homo sapiens_hsa041220.90511536
71Insulin signaling pathway_Homo sapiens_hsa049100.90064541
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.89457596
73p53 signaling pathway_Homo sapiens_hsa041150.89175520
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86760583
75MicroRNAs in cancer_Homo sapiens_hsa052060.86292403
76Viral carcinogenesis_Homo sapiens_hsa052030.85294844
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82996538
78Parkinsons disease_Homo sapiens_hsa050120.82888708
79Dopaminergic synapse_Homo sapiens_hsa047280.82801068
80Taste transduction_Homo sapiens_hsa047420.80948292
81Pentose phosphate pathway_Homo sapiens_hsa000300.80536664
82HTLV-I infection_Homo sapiens_hsa051660.80390795
83Alcoholism_Homo sapiens_hsa050340.79984492
84mTOR signaling pathway_Homo sapiens_hsa041500.79567434
85Protein export_Homo sapiens_hsa030600.79340124
86Nicotine addiction_Homo sapiens_hsa050330.78171078
87Melanoma_Homo sapiens_hsa052180.77553325
88Gap junction_Homo sapiens_hsa045400.76702438
89Bile secretion_Homo sapiens_hsa049760.76658139
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76396470
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76334531
92Axon guidance_Homo sapiens_hsa043600.75510475
93Oxidative phosphorylation_Homo sapiens_hsa001900.75309706
94Phagosome_Homo sapiens_hsa041450.74810957
95Circadian rhythm_Homo sapiens_hsa047100.74575132
96N-Glycan biosynthesis_Homo sapiens_hsa005100.73587427
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73225452
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.72868171
99Shigellosis_Homo sapiens_hsa051310.72487734
100Cardiac muscle contraction_Homo sapiens_hsa042600.72209636
101Glioma_Homo sapiens_hsa052140.71687834
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71553029
103Melanogenesis_Homo sapiens_hsa049160.70599073
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70594253
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70578997
106Adherens junction_Homo sapiens_hsa045200.70297541
107Thyroid hormone synthesis_Homo sapiens_hsa049180.69996698
108Chronic myeloid leukemia_Homo sapiens_hsa052200.69457219
109Fatty acid biosynthesis_Homo sapiens_hsa000610.69142869
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69110491
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69025490
112TGF-beta signaling pathway_Homo sapiens_hsa043500.67855312
113Pancreatic cancer_Homo sapiens_hsa052120.67240971
114Serotonergic synapse_Homo sapiens_hsa047260.67159566
115Choline metabolism in cancer_Homo sapiens_hsa052310.66682606
116Circadian entrainment_Homo sapiens_hsa047130.66040643
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65525365
118Prion diseases_Homo sapiens_hsa050200.65437565
119ErbB signaling pathway_Homo sapiens_hsa040120.64636355
120Salivary secretion_Homo sapiens_hsa049700.63591854
121Insulin secretion_Homo sapiens_hsa049110.63204258
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62738837
123Insulin resistance_Homo sapiens_hsa049310.62265391
124Fatty acid degradation_Homo sapiens_hsa000710.61294739
125Pathways in cancer_Homo sapiens_hsa052000.60937595
126Other glycan degradation_Homo sapiens_hsa005110.60304847
127Small cell lung cancer_Homo sapiens_hsa052220.60147926
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59117272
129Endometrial cancer_Homo sapiens_hsa052130.58943093
130Ovarian steroidogenesis_Homo sapiens_hsa049130.58936008
131Proteoglycans in cancer_Homo sapiens_hsa052050.58385128
132Sphingolipid metabolism_Homo sapiens_hsa006000.58226539
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56404521
134Amphetamine addiction_Homo sapiens_hsa050310.56335189
135Non-small cell lung cancer_Homo sapiens_hsa052230.55606175
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.55434374
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55276868
138Cholinergic synapse_Homo sapiens_hsa047250.55042961
139Galactose metabolism_Homo sapiens_hsa000520.55021184
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54727443
141Dilated cardiomyopathy_Homo sapiens_hsa054140.54460558
142Glutamatergic synapse_Homo sapiens_hsa047240.54182320
143Thyroid cancer_Homo sapiens_hsa052160.53994243
144VEGF signaling pathway_Homo sapiens_hsa043700.53634674
145Gastric acid secretion_Homo sapiens_hsa049710.53495100
146Alzheimers disease_Homo sapiens_hsa050100.53402693
147Long-term potentiation_Homo sapiens_hsa047200.53122736
148Focal adhesion_Homo sapiens_hsa045100.53031939
149Oxytocin signaling pathway_Homo sapiens_hsa049210.52336577
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.52281620
151Estrogen signaling pathway_Homo sapiens_hsa049150.51964841
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51124896
153Steroid biosynthesis_Homo sapiens_hsa001000.50994007
154GnRH signaling pathway_Homo sapiens_hsa049120.50627145
155Morphine addiction_Homo sapiens_hsa050320.49476783
156Fatty acid metabolism_Homo sapiens_hsa012120.49329331
157GABAergic synapse_Homo sapiens_hsa047270.48247961
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47863201
159One carbon pool by folate_Homo sapiens_hsa006700.47305273
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47304463
161Inositol phosphate metabolism_Homo sapiens_hsa005620.47172222
162Tight junction_Homo sapiens_hsa045300.46764720
163Propanoate metabolism_Homo sapiens_hsa006400.46478511
164ECM-receptor interaction_Homo sapiens_hsa045120.45964747
165Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45346506
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.44478638

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