GAST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to iron ion (GO:0010039)9.67871742
2fibril organization (GO:0097435)9.62815416
3O-glycan processing (GO:0016266)8.66453422
4glutathione derivative biosynthetic process (GO:1901687)8.63845745
5glutathione derivative metabolic process (GO:1901685)8.63845745
6glandular epithelial cell differentiation (GO:0002067)8.48563314
7digestive system process (GO:0022600)8.21105805
8negative regulation of digestive system process (GO:0060457)7.92278475
9protein autoprocessing (GO:0016540)7.80311131
10sulfation (GO:0051923)7.75794535
11bundle of His cell to Purkinje myocyte communication (GO:0086069)7.14617803
12kidney morphogenesis (GO:0060993)6.61764083
133-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.33416448
14purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.33416448
15protein O-linked glycosylation (GO:0006493)6.21747126
16production of molecular mediator of immune response (GO:0002440)5.45569079
17intestinal absorption (GO:0050892)5.42106939
18fucose catabolic process (GO:0019317)5.33182463
19L-fucose metabolic process (GO:0042354)5.33182463
20L-fucose catabolic process (GO:0042355)5.33182463
21sulfur amino acid catabolic process (GO:0000098)4.85702011
22glutathione metabolic process (GO:0006749)4.62456140
23thyroid hormone metabolic process (GO:0042403)4.62301807
24nitric oxide biosynthetic process (GO:0006809)4.25511333
25thyroid hormone generation (GO:0006590)4.21248396
26columnar/cuboidal epithelial cell differentiation (GO:0002065)4.16661912
27phospholipid scrambling (GO:0017121)4.11310237
28receptor recycling (GO:0001881)4.02655139
29lung secretory cell differentiation (GO:0061140)4.00159512
30xenobiotic metabolic process (GO:0006805)3.94327963
31cellular response to oxygen radical (GO:0071450)3.61013223
32removal of superoxide radicals (GO:0019430)3.61013223
33cellular response to superoxide (GO:0071451)3.61013223
34ventricular cardiac muscle cell action potential (GO:0086005)3.59119745
35regulation of macrophage activation (GO:0043030)3.45954716
36cyclooxygenase pathway (GO:0019371)3.44559738
37COPI coating of Golgi vesicle (GO:0048205)3.43620574
38Golgi transport vesicle coating (GO:0048200)3.43620574
39acrosome reaction (GO:0007340)3.32798793
40response to superoxide (GO:0000303)3.20997952
41cellular response to gonadotropin stimulus (GO:0071371)3.20872994
42regulation of heart rate by cardiac conduction (GO:0086091)3.19449395
43nucleotide-sugar biosynthetic process (GO:0009226)3.14165026
44fucose metabolic process (GO:0006004)3.12328393
45regulation of proton transport (GO:0010155)3.12213570
46cell communication involved in cardiac conduction (GO:0086065)3.08818451
47negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.08294895
48nucleoside bisphosphate metabolic process (GO:0033865)3.05146287
49purine nucleoside bisphosphate metabolic process (GO:0034032)3.05146287
50ribonucleoside bisphosphate metabolic process (GO:0033875)3.05146287
51GDP-mannose metabolic process (GO:0019673)3.03479821
52intestinal epithelial cell development (GO:0060576)3.01963789
53response to oxygen radical (GO:0000305)2.98283596
54cellular response to arsenic-containing substance (GO:0071243)2.93932481
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89684272
56cardiac conduction (GO:0061337)2.87056701
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.84928812
58regulation of digestive system process (GO:0044058)2.79687252
59atrioventricular valve morphogenesis (GO:0003181)2.77394356
60L-serine transport (GO:0015825)2.76166370
61desmosome organization (GO:0002934)2.69439331
62regulation of pH (GO:0006885)2.65890304
63response to transition metal nanoparticle (GO:1990267)2.65709163
64regulation of cardioblast differentiation (GO:0051890)2.65409142
65fucosylation (GO:0036065)2.64014766
66hormone catabolic process (GO:0042447)2.59843814
67cellular glucuronidation (GO:0052695)2.57489817
68flavonoid metabolic process (GO:0009812)2.57482872
69positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.55234500
70uronic acid metabolic process (GO:0006063)2.54921722
71glucuronate metabolic process (GO:0019585)2.54921722
72sphingolipid biosynthetic process (GO:0030148)2.49254054
73lung cell differentiation (GO:0060479)2.48405123
74peptide metabolic process (GO:0006518)2.47966456
75synaptic transmission, cholinergic (GO:0007271)2.47341846
76embryonic foregut morphogenesis (GO:0048617)2.46041307
77regulation of cholesterol homeostasis (GO:2000188)2.44025252
78response to gonadotropin (GO:0034698)2.43245967
79hepatocyte apoptotic process (GO:0097284)2.42372905
80phosphatidylserine metabolic process (GO:0006658)2.41559941
81diacylglycerol metabolic process (GO:0046339)2.41498160
82lung epithelial cell differentiation (GO:0060487)2.40591623
83negative regulation of sterol transport (GO:0032372)2.37763494
84negative regulation of cholesterol transport (GO:0032375)2.37763494
85hexose catabolic process (GO:0019320)2.37483590
86serine transport (GO:0032329)2.37323928
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36243419
88post-translational protein modification (GO:0043687)2.32794431
89protein glycosylation (GO:0006486)2.32373205
90macromolecule glycosylation (GO:0043413)2.32373205
91epithelial cell-cell adhesion (GO:0090136)2.31081434
92sodium ion export (GO:0071436)2.29849410
93regulation of transforming growth factor beta1 production (GO:0032908)2.28156417
94xenobiotic catabolic process (GO:0042178)2.27067311
95protein retention in ER lumen (GO:0006621)2.26561549
96glycosylation (GO:0070085)2.26487514
97maintenance of gastrointestinal epithelium (GO:0030277)19.9817629
98epithelial structure maintenance (GO:0010669)14.7965249
99extracellular fibril organization (GO:0043206)11.3048692
100digestion (GO:0007586)10.4469056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human7.83122715
2SOX2_27498859_Chip-Seq_STOMACH_Mouse5.87081925
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.52248090
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.93367374
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.58230597
6SOX2_20726797_ChIP-Seq_SW620_Human2.86715037
7HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.85518613
8GATA4_25053715_ChIP-Seq_YYC3_Human2.82627809
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80107913
10ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.66312169
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.58161771
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57160092
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.51471432
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.29158871
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.29131403
16GATA6_25053715_ChIP-Seq_YYC3_Human2.07145493
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.06278651
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00509519
19VDR_22108803_ChIP-Seq_LS180_Human1.99621020
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96967197
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.84234435
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83968797
23STAT1_20625510_ChIP-Seq_HELA_Human1.81622250
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78777841
25AHR_22903824_ChIP-Seq_MCF-7_Human1.76401715
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.73942373
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73665859
28* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60707312
29AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.60528811
30GATA3_24758297_ChIP-Seq_MCF-7_Human1.57371632
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56168857
32JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54741905
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.52384370
34* RXR_22158963_ChIP-Seq_LIVER_Mouse1.51451754
35KLF5_25053715_ChIP-Seq_YYC3_Human1.48519341
36* LXR_22158963_ChIP-Seq_LIVER_Mouse1.45691314
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45071863
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.40139432
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37163317
40ZNF274_21170338_ChIP-Seq_K562_Hela1.36659703
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36340321
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34846938
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34846938
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34656531
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29168584
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27658385
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27082786
48ZNF263_19887448_ChIP-Seq_K562_Human1.22854619
49RACK7_27058665_Chip-Seq_MCF-7_Human1.19208653
50LXR_22292898_ChIP-Seq_THP-1_Human1.18444872
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.18390047
52CLOCK_20551151_ChIP-Seq_293T_Human1.16684201
53RXR_22108803_ChIP-Seq_LS180_Human1.15914040
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15725370
55* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15584931
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15164291
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.13083389
58BCAT_22108803_ChIP-Seq_LS180_Human1.12536508
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11688331
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09608604
61* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07312936
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07206573
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04956521
64CJUN_26792858_Chip-Seq_BT549_Human1.04367330
65KDM2B_26808549_Chip-Seq_K562_Human1.02221843
66SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99770257
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99196726
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99085393
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97986603
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97984809
71TCF4_18268006_ChIP-ChIP_LS174T_Human0.97962681
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97430792
73NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97430792
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96867382
75FOXO3_23340844_ChIP-Seq_DLD1_Human0.96550649
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95167822
77RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95075739
78* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91047072
79FOXA1_25552417_ChIP-Seq_VCAP_Human0.90695457
80DROSHA_22980978_ChIP-Seq_HELA_Human0.89910677
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88451568
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88088877
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85496242
84ATF3_27146783_Chip-Seq_COLON_Human0.84451995
85P53_21459846_ChIP-Seq_SAOS-2_Human0.82384560
86SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81822587
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81688845
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81475298
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80532321
90GATA1_19941826_ChIP-Seq_K562_Human0.80333748
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.78912408
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78026530
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77640091
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77225345
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.73612015
96TBX20_22328084_ChIP-Seq_HEART_Mouse0.73161200
97TBX20_22080862_ChIP-Seq_HEART_Mouse0.73161200
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.72336578
99TP63_23658742_ChIP-Seq_EP156T_Human0.71094591
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70326329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001664_abnormal_digestion6.63426047
2MP0003806_abnormal_nucleotide_metabolis6.17088251
3* MP0000470_abnormal_stomach_morphology4.59332905
4* MP0001873_stomach_inflammation4.03083179
5MP0010234_abnormal_vibrissa_follicle3.40357065
6MP0005165_increased_susceptibility_to2.79500126
7MP0003283_abnormal_digestive_organ2.50626915
8MP0004264_abnormal_extraembryonic_tissu2.48225712
9MP0002909_abnormal_adrenal_gland2.44528787
10* MP0001663_abnormal_digestive_system2.22002473
11* MP0005381_digestive/alimentary_phenotyp2.06188571
12* MP0008004_abnormal_stomach_pH12.5565988
13MP0003186_abnormal_redox_activity1.96506831
14MP0006054_spinal_hemorrhage1.88368669
15MP0000013_abnormal_adipose_tissue1.81309424
16MP0002877_abnormal_melanocyte_morpholog1.73272461
17* MP0000477_abnormal_intestine_morphology1.65546006
18MP0003705_abnormal_hypodermis_morpholog1.59526029
19MP0000462_abnormal_digestive_system1.58973710
20MP0005365_abnormal_bile_salt1.57711592
21MP0005085_abnormal_gallbladder_physiolo1.47885496
22MP0005083_abnormal_biliary_tract1.45306647
23MP0002234_abnormal_pharynx_morphology1.42643403
24MP0009780_abnormal_chondrocyte_physiolo1.35004749
25MP0009384_cardiac_valve_regurgitation1.24808428
26MP0000490_abnormal_crypts_of1.21704573
27MP0002139_abnormal_hepatobiliary_system1.15287954
28MP0005266_abnormal_metabolism1.12379577
29MP0004858_abnormal_nervous_system1.06481386
30MP0008875_abnormal_xenobiotic_pharmacok1.04400823
31MP0000537_abnormal_urethra_morphology0.97333334
32MP0010155_abnormal_intestine_physiology0.95424145
33MP0001666_abnormal_nutrient_absorption0.94840956
34MP0002009_preneoplasia0.94693740
35MP0004484_altered_response_of0.88894108
36MP0003075_altered_response_to0.85182419
37MP0004185_abnormal_adipocyte_glucose0.84929250
38MP0002796_impaired_skin_barrier0.84775763
39MP0003866_abnormal_defecation0.84623159
40MP0005408_hypopigmentation0.84214676
41MP0001243_abnormal_dermal_layer0.84161051
42MP0003724_increased_susceptibility_to0.83965382
43MP0003183_abnormal_peptide_metabolism0.83229729
44MP0005645_abnormal_hypothalamus_physiol0.82321283
45MP0000003_abnormal_adipose_tissue0.80860982
46MP0004043_abnormal_pH_regulation0.80528422
47MP0000467_abnormal_esophagus_morphology0.75571776
48MP0010329_abnormal_lipoprotein_level0.75545476
49MP0003566_abnormal_cell_adhesion0.73838943
50MP0003638_abnormal_response/metabolism_0.69004280
51MP0004947_skin_inflammation0.68986063
52MP0010352_gastrointestinal_tract_polyps0.68426787
53MP0004270_analgesia0.65336425
54* MP0005636_abnormal_mineral_homeostasis0.64895174
55MP0003252_abnormal_bile_duct0.64003310
56MP0002118_abnormal_lipid_homeostasis0.63066070
57MP0005584_abnormal_enzyme/coenzyme_acti0.62954389
58* MP0002078_abnormal_glucose_homeostasis0.62733063
59MP0000609_abnormal_liver_physiology0.60918472
60MP0008961_abnormal_basal_metabolism0.59307764
61MP0003119_abnormal_digestive_system0.58755741
62MP0002060_abnormal_skin_morphology0.58251036
63MP0001216_abnormal_epidermal_layer0.57275437
64MP0003123_paternal_imprinting0.56583173
65MP0002837_dystrophic_cardiac_calcinosis0.55655966
66MP0010678_abnormal_skin_adnexa0.50534629
67MP0005166_decreased_susceptibility_to0.49449336
68MP0001944_abnormal_pancreas_morphology0.49174755
69MP0005076_abnormal_cell_differentiation0.48633121
70MP0005220_abnormal_exocrine_pancreas0.48431471
71MP0003453_abnormal_keratinocyte_physiol0.48299100
72MP0005332_abnormal_amino_acid0.48144276
73MP0003329_amyloid_beta_deposits0.47965878
74* MP0003953_abnormal_hormone_level0.47554140
75MP0004859_abnormal_synaptic_plasticity0.47386560
76MP0003959_abnormal_lean_body0.46629008
77MP0005376_homeostasis/metabolism_phenot0.45447208
78MP0005319_abnormal_enzyme/_coenzyme0.45103238
79MP0000613_abnormal_salivary_gland0.43703133
80MP0002733_abnormal_thermal_nociception0.43285356
81MP0003122_maternal_imprinting0.42104536
82MP0001849_ear_inflammation0.41507913
83MP0000598_abnormal_liver_morphology0.40934568
84MP0005310_abnormal_salivary_gland0.40933219
85MP0002896_abnormal_bone_mineralization0.40377088
86MP0000367_abnormal_coat/_hair0.38443175
87MP0003195_calcinosis0.37642368
88MP0009643_abnormal_urine_homeostasis0.37313628
89MP0002970_abnormal_white_adipose0.36852151
90MP0002098_abnormal_vibrissa_morphology0.36337557
91MP0010386_abnormal_urinary_bladder0.36237457
92MP0003656_abnormal_erythrocyte_physiolo0.35730112
93MP0004019_abnormal_vitamin_homeostasis0.35434590
94MP0003191_abnormal_cellular_cholesterol0.33900416
95* MP0009642_abnormal_blood_homeostasis0.32181854
96MP0005375_adipose_tissue_phenotype0.32024490
97* MP0002019_abnormal_tumor_incidence0.31042287
98MP0004130_abnormal_muscle_cell0.30969355
99MP0005464_abnormal_platelet_physiology0.30945139
100MP0005501_abnormal_skin_physiology0.30774062

Predicted human phenotypes

RankGene SetZ-score
1Palpitations (HP:0001962)5.25366698
2Agitation (HP:0000713)4.17752207
3Woolly hair (HP:0002224)4.13663016
4Abnormality of purine metabolism (HP:0004352)3.95941134
5Goiter (HP:0000853)3.90102789
6Intrahepatic cholestasis (HP:0001406)3.80767949
7Syncope (HP:0001279)3.75952048
8Flat acetabular roof (HP:0003180)3.62783593
9Gout (HP:0001997)3.55608618
10Hyperglycemia (HP:0003074)3.43969293
11Arterial tortuosity (HP:0005116)3.33406386
12Cupped ribs (HP:0000887)3.20045196
13Frequent falls (HP:0002359)3.04158159
14Back pain (HP:0003418)2.97255369
15Vascular tortuosity (HP:0004948)2.90936697
16Infantile muscular hypotonia (HP:0008947)2.88743356
17Axonal loss (HP:0003447)2.84011106
18Hypoglycemic coma (HP:0001325)2.83757518
19Abdominal distention (HP:0003270)2.78232537
20Hemiplegia (HP:0002301)2.77353954
21Ventricular arrhythmia (HP:0004308)2.75287485
22Vertebral hypoplasia (HP:0008417)2.74589309
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.74589309
24Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72076547
25Restlessness (HP:0000711)2.71116007
26Micronodular cirrhosis (HP:0001413)2.62842833
27Conjugated hyperbilirubinemia (HP:0002908)2.60271871
28Ventricular tachycardia (HP:0004756)2.59496462
29Hypoplastic ischia (HP:0003175)2.57059470
30Abnormal tarsal ossification (HP:0008369)2.51018991
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50324861
32Ankyloglossia (HP:0010296)2.46257487
33Growth hormone excess (HP:0000845)2.44926352
34Thoracolumbar scoliosis (HP:0002944)2.44526405
35Hyperuricemia (HP:0002149)2.40694764
36Increased purine levels (HP:0004368)2.40694764
37Abnormal cartilage morphology (HP:0002763)2.37736759
38Hemorrhage of the eye (HP:0011885)2.37281349
39Epiphyseal dysplasia (HP:0002656)2.36826847
40Ketoacidosis (HP:0001993)2.34892688
41Sensorimotor neuropathy (HP:0007141)2.33667939
42Generalized hypopigmentation of hair (HP:0011358)2.33303107
43Glomerulosclerosis (HP:0000096)2.32653041
44Ventricular fibrillation (HP:0001663)2.30145900
45Deep venous thrombosis (HP:0002625)2.28067753
46Increased variability in muscle fiber diameter (HP:0003557)2.22890096
47Curly hair (HP:0002212)2.21899363
48Flattened epiphyses (HP:0003071)2.19661950
49Abnormality of nucleobase metabolism (HP:0010932)2.19168765
50Abnormality of the ischium (HP:0003174)2.17519976
51Esophageal varix (HP:0002040)2.16218350
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15701527
53Atrophic scars (HP:0001075)2.13889953
54Ectopia lentis (HP:0001083)2.10426575
55Testicular neoplasm (HP:0010788)2.08579223
56Insulin-resistant diabetes mellitus (HP:0000831)2.05769982
57Focal segmental glomerulosclerosis (HP:0000097)2.05026825
58Abnormality of the gastric mucosa (HP:0004295)2.03936216
59Irregular epiphyses (HP:0010582)2.02931787
60Abnormality of skeletal muscle fiber size (HP:0012084)2.01728184
61Spinal rigidity (HP:0003306)2.01576266
62Right ventricular cardiomyopathy (HP:0011663)10.0381749
63Neuroendocrine neoplasm (HP:0100634)1.99263997
64Metaphyseal cupping (HP:0003021)1.98485396
65Hypoglycemic seizures (HP:0002173)1.97723483
66Protuberant abdomen (HP:0001538)1.96772726
67Abnormality of sulfur amino acid metabolism (HP:0004339)1.94531647
68Mildly elevated creatine phosphokinase (HP:0008180)1.94261369
69Abnormal foot bone ossification (HP:0010675)1.93646633
70Hyperinsulinemic hypoglycemia (HP:0000825)1.92766674
71Vascular calcification (HP:0004934)1.92466865
72Pheochromocytoma (HP:0002666)1.92079537
73Sudden cardiac death (HP:0001645)1.91963438
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91933961
75Ketosis (HP:0001946)1.91637634
76Abnormality of the vitreous humor (HP:0004327)1.90220292
77Xanthomatosis (HP:0000991)1.87035465
78Severe short stature (HP:0003510)1.86996142
79Spinal cord compression (HP:0002176)1.85997398
80Periodontitis (HP:0000704)1.83299211
81Polygenic inheritance (HP:0010982)1.83188172
82Macroglossia (HP:0000158)1.82911258
83Late onset (HP:0003584)1.78997959
84Flat capital femoral epiphysis (HP:0003370)1.78797791
85Cardiovascular calcification (HP:0011915)1.76544998
86Vitreoretinal degeneration (HP:0000655)1.76333775
87Hoarse voice (HP:0001609)1.74505073
88Abnormality of the Achilles tendon (HP:0005109)1.74240569
89Vertebral clefting (HP:0008428)1.73570016
90Abnormal biliary tract morphology (HP:0012440)1.73389296
91Hand muscle atrophy (HP:0009130)1.73122388
92Insulin resistance (HP:0000855)1.72952299
93Abnormality of oral frenula (HP:0000190)1.72748271
94Achilles tendon contracture (HP:0001771)1.72566278
95Cone-rod dystrophy (HP:0000548)1.72085634
96Rimmed vacuoles (HP:0003805)1.72019017
97Mucopolysacchariduria (HP:0008155)1.71912413
98Urinary glycosaminoglycan excretion (HP:0003541)1.71912413
99Cerebral hemorrhage (HP:0001342)1.66615575
100Conjunctival hamartoma (HP:0100780)1.66427333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.56687891
2MST1R5.72610579
3MAP3K93.22714084
4PIK3CG3.12904257
5MAP3K22.89484788
6KSR22.63156444
7MET2.53296500
8TRIB32.43580492
9PKN22.40470133
10FER2.23069608
11MAP2K22.22775114
12WNK32.20410449
13FRK2.18171493
14LRRK22.06537476
15MAP2K12.05467148
16RIPK42.03143260
17PRKG21.82445225
18PAK31.62423662
19WNK41.57972571
20NME11.51348225
21PTK61.50633756
22NUAK11.49312831
23RIPK11.47244395
24STK101.32026296
25TAOK11.30033755
26TESK11.28612784
27MAP3K31.28128479
28PRKCI1.28106846
29ERN11.24864771
30DDR21.24654902
31LMTK21.14788310
32MAP3K131.13924823
33STK391.11353700
34ARAF1.11186163
35MAPK151.09150761
36PTK20.95298296
37MAP3K10.93915001
38ICK0.92259505
39MAP3K100.88311097
40BMX0.85505063
41PDK40.77710005
42PDK30.77710005
43ERBB20.77421930
44NEK10.76073813
45PDGFRB0.74076081
46RET0.71140370
47CSK0.69689416
48MAP3K80.69408655
49KSR10.68958028
50LIMK10.66373441
51MAP3K110.66050755
52NTRK30.64714503
53EPHB10.64679865
54PDPK10.63572222
55ROCK20.62066401
56MINK10.60629010
57CAMKK10.60605762
58PAK40.58407535
59CAMK2B0.57162244
60DMPK0.55194088
61UHMK10.54018656
62SCYL20.53764223
63NTRK10.52404498
64CAMK2D0.50180754
65PDK10.48189033
66* ERBB40.47494491
67PASK0.46404573
68ALK0.45970885
69MAP3K120.45186704
70HIPK20.44512254
71BCKDK0.43954469
72RAF10.43354438
73EEF2K0.40679016
74* SRC0.40594194
75RPS6KA20.39555909
76CDK50.39536158
77TAOK30.37864718
78PRKCQ0.36447552
79EGFR0.36019746
80RPS6KB20.34651524
81PDK20.34414785
82PRKD10.34289757
83CDK190.33839318
84CAMK2G0.32906115
85DYRK1B0.31821897
86EPHA20.29638637
87ROCK10.27952050
88* FYN0.26768632
89ADRBK10.25833629
90BCR0.24867721
91CAMKK20.24326904
92PIM20.22992792
93PDGFRA0.22213890
94GRK60.22039661
95RPS6KA10.21680060
96PAK60.21248780
97MAP2K40.21049297
98JAK20.20815670
99IGF1R0.20754310
100CAMK2A0.19466399

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.07020999
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.41822683
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005125.21469121
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.41237741
5Chemical carcinogenesis_Homo sapiens_hsa052043.81121724
6Glutathione metabolism_Homo sapiens_hsa004803.66602614
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.45310698
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21692550
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.21128401
10* Gastric acid secretion_Homo sapiens_hsa049711.99259038
11Mineral absorption_Homo sapiens_hsa049781.80751119
12Nitrogen metabolism_Homo sapiens_hsa009101.53092897
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44632102
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39187073
15Sulfur relay system_Homo sapiens_hsa041221.27109050
16Thyroid hormone synthesis_Homo sapiens_hsa049181.17859104
17Fatty acid degradation_Homo sapiens_hsa000711.11918185
18Pyruvate metabolism_Homo sapiens_hsa006201.10900806
19Collecting duct acid secretion_Homo sapiens_hsa049661.06770757
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03058119
21Pancreatic secretion_Homo sapiens_hsa049721.00286914
22Retinol metabolism_Homo sapiens_hsa008300.95561438
23Butanoate metabolism_Homo sapiens_hsa006500.83380711
24Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81701158
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80703442
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77867359
27Histidine metabolism_Homo sapiens_hsa003400.75801997
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75444744
29Folate biosynthesis_Homo sapiens_hsa007900.74577845
30Ether lipid metabolism_Homo sapiens_hsa005650.74368210
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73002776
32Fat digestion and absorption_Homo sapiens_hsa049750.72625632
33Phenylalanine metabolism_Homo sapiens_hsa003600.70445911
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70233094
35Bile secretion_Homo sapiens_hsa049760.70100972
36Propanoate metabolism_Homo sapiens_hsa006400.69867784
37Thyroid cancer_Homo sapiens_hsa052160.69393617
38Insulin secretion_Homo sapiens_hsa049110.68501633
39Carbon metabolism_Homo sapiens_hsa012000.65767804
40Vibrio cholerae infection_Homo sapiens_hsa051100.64826411
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62482826
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60633663
43Tight junction_Homo sapiens_hsa045300.59635673
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59153640
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57973336
46Dorso-ventral axis formation_Homo sapiens_hsa043200.57241431
47Fatty acid metabolism_Homo sapiens_hsa012120.56920853
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56185554
49Lysosome_Homo sapiens_hsa041420.53444359
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53155861
51PPAR signaling pathway_Homo sapiens_hsa033200.53052397
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52696768
53beta-Alanine metabolism_Homo sapiens_hsa004100.50872158
54Linoleic acid metabolism_Homo sapiens_hsa005910.48403757
55Glycerolipid metabolism_Homo sapiens_hsa005610.46979494
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46048989
57Arginine biosynthesis_Homo sapiens_hsa002200.44536022
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44085660
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42279987
60Fructose and mannose metabolism_Homo sapiens_hsa000510.41525069
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.38765712
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38218955
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37457281
64Pentose phosphate pathway_Homo sapiens_hsa000300.37167177
65Long-term potentiation_Homo sapiens_hsa047200.36528588
66Starch and sucrose metabolism_Homo sapiens_hsa005000.36050673
67Tryptophan metabolism_Homo sapiens_hsa003800.35477146
68GABAergic synapse_Homo sapiens_hsa047270.34255574
69Renin secretion_Homo sapiens_hsa049240.33964937
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.32063165
71ABC transporters_Homo sapiens_hsa020100.30314152
72Circadian entrainment_Homo sapiens_hsa047130.29634679
73Estrogen signaling pathway_Homo sapiens_hsa049150.28311463
74Fatty acid elongation_Homo sapiens_hsa000620.26768491
75Salivary secretion_Homo sapiens_hsa049700.26415604
76Cholinergic synapse_Homo sapiens_hsa047250.26264164
77Type II diabetes mellitus_Homo sapiens_hsa049300.26235299
78Cocaine addiction_Homo sapiens_hsa050300.26023723
79Oxidative phosphorylation_Homo sapiens_hsa001900.24494636
80Dopaminergic synapse_Homo sapiens_hsa047280.24484051
81Alzheimers disease_Homo sapiens_hsa050100.24428211
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24123120
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23212795
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.22756354
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22339879
86Adherens junction_Homo sapiens_hsa045200.21888517
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.21119262
88Long-term depression_Homo sapiens_hsa047300.20666064
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20287692
90Bladder cancer_Homo sapiens_hsa052190.20253904
91GnRH signaling pathway_Homo sapiens_hsa049120.19961037
92Amphetamine addiction_Homo sapiens_hsa050310.18574549
93Salmonella infection_Homo sapiens_hsa051320.18121496
94Cardiac muscle contraction_Homo sapiens_hsa042600.17696724
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17625755
96Peroxisome_Homo sapiens_hsa041460.17008553
97Galactose metabolism_Homo sapiens_hsa000520.16374560
98Synaptic vesicle cycle_Homo sapiens_hsa047210.16143043
99Glucagon signaling pathway_Homo sapiens_hsa049220.15714399
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.15371004

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