GATA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.40656587
2* definitive hemopoiesis (GO:0060216)7.02409963
3megakaryocyte development (GO:0035855)6.31030998
4negative regulation of erythrocyte differentiation (GO:0045647)5.70570887
5viral transcription (GO:0019083)5.53695303
6translational termination (GO:0006415)5.32318924
7positive regulation of natural killer cell differentiation (GO:0032825)5.20201374
8platelet dense granule organization (GO:0060155)5.00048110
9antigen processing and presentation via MHC class Ib (GO:0002475)4.89974789
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.69543561
11endothelium development (GO:0003158)4.67884453
12maturation of SSU-rRNA (GO:0030490)4.65772255
13translational elongation (GO:0006414)4.63469229
14ribosomal small subunit biogenesis (GO:0042274)4.61847565
15cotranslational protein targeting to membrane (GO:0006613)4.57491107
16protein targeting to ER (GO:0045047)4.57148778
17positive regulation of B cell differentiation (GO:0045579)4.51471740
18dosage compensation (GO:0007549)4.44751144
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.36870056
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36636930
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.34071117
22protein localization to endoplasmic reticulum (GO:0070972)4.31268630
23fucose catabolic process (GO:0019317)4.30643492
24L-fucose metabolic process (GO:0042354)4.30643492
25L-fucose catabolic process (GO:0042355)4.30643492
26embryonic hemopoiesis (GO:0035162)4.28065821
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12796029
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12796029
29nucleosome disassembly (GO:0006337)4.04356159
30protein-DNA complex disassembly (GO:0032986)4.04356159
31viral life cycle (GO:0019058)4.02597208
32protoporphyrinogen IX metabolic process (GO:0046501)4.01200245
33cellular protein complex disassembly (GO:0043624)3.91016302
34Peyers patch development (GO:0048541)3.90062857
35mucosal-associated lymphoid tissue development (GO:0048537)3.90062857
36regulation of natural killer cell differentiation (GO:0032823)3.89867504
37thrombin receptor signaling pathway (GO:0070493)3.84456012
38secretory granule organization (GO:0033363)3.82847049
39* regulation of erythrocyte differentiation (GO:0045646)3.79369591
40positive regulation of gamma-delta T cell activation (GO:0046645)3.78208756
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77116419
42translational initiation (GO:0006413)3.72983321
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.72887646
44erythrocyte maturation (GO:0043249)3.70319096
45* positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.66474325
46poly(A)+ mRNA export from nucleus (GO:0016973)3.64231864
47protein complex disassembly (GO:0043241)3.60844376
48pyrimidine nucleotide catabolic process (GO:0006244)3.59555312
49heparin biosynthetic process (GO:0030210)3.57093663
50heparin metabolic process (GO:0030202)3.57093663
51biotin metabolic process (GO:0006768)3.50202995
52myeloid cell development (GO:0061515)3.45522186
53lymphoid progenitor cell differentiation (GO:0002320)3.45359498
54DNA deamination (GO:0045006)3.42281564
55T cell homeostasis (GO:0043029)3.39958058
56nuclear-transcribed mRNA catabolic process (GO:0000956)3.39548669
57mature B cell differentiation involved in immune response (GO:0002313)3.37284825
58protoporphyrinogen IX biosynthetic process (GO:0006782)3.36769335
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.32949546
60macromolecular complex disassembly (GO:0032984)3.32747817
61toxin transport (GO:1901998)3.32508125
62granulocyte differentiation (GO:0030851)3.29701408
63lymph node development (GO:0048535)3.27894007
64regulation of histone phosphorylation (GO:0033127)3.25601002
65hematopoietic stem cell differentiation (GO:0060218)3.25048908
66mRNA catabolic process (GO:0006402)3.23687780
67regulation of gamma-delta T cell differentiation (GO:0045586)3.23272429
68UV protection (GO:0009650)3.21955214
69DNA topological change (GO:0006265)3.20383308
70negative regulation of phagocytosis (GO:0050765)3.18325641
71antigen processing and presentation of endogenous antigen (GO:0019883)3.18303912
72response to thyroid hormone (GO:0097066)3.17634557
73positive regulation of granulocyte differentiation (GO:0030854)3.16743380
74response to interferon-beta (GO:0035456)3.15512639
75regulation of translational fidelity (GO:0006450)3.14532789
76pentose-phosphate shunt (GO:0006098)3.14160114
77tRNA methylation (GO:0030488)3.11442012
78response to interferon-alpha (GO:0035455)3.05431255
79protein targeting to membrane (GO:0006612)3.04513357
80negative regulation of mRNA processing (GO:0050686)3.04161886
81histamine transport (GO:0051608)3.04003181
82RNA catabolic process (GO:0006401)3.02675529
83positive regulation of odontogenesis (GO:0042482)3.02091547
84regulation of necroptotic process (GO:0060544)2.99690149
85necroptotic process (GO:0070266)2.97964034
86DNA replication initiation (GO:0006270)2.95078915
87negative regulation of bone mineralization (GO:0030502)2.93504835
88polyketide metabolic process (GO:0030638)2.92988877
89doxorubicin metabolic process (GO:0044598)2.92988877
90daunorubicin metabolic process (GO:0044597)2.92988877
91T cell differentiation in thymus (GO:0033077)2.92688242
92pseudouridine synthesis (GO:0001522)2.92287177
93proline biosynthetic process (GO:0006561)2.91683932
94ribosomal large subunit biogenesis (GO:0042273)2.89934625
95IMP biosynthetic process (GO:0006188)2.89870320
96regulation of histone H3-K9 methylation (GO:0051570)2.89515195
97pentose metabolic process (GO:0019321)2.89255433
98negative regulation of stress fiber assembly (GO:0051497)2.88824883
99negative regulation of mRNA metabolic process (GO:1903312)2.85549349
100endosome to melanosome transport (GO:0035646)2.85452766
101endosome to pigment granule transport (GO:0043485)2.85452766
102regulation of mast cell degranulation (GO:0043304)2.84589942
103production of molecular mediator involved in inflammatory response (GO:0002532)2.84272495
104cellular response to thyroid hormone stimulus (GO:0097067)2.84167188
105erythrocyte development (GO:0048821)2.83615135
106negative regulation of histone methylation (GO:0031061)2.83429165
107cytokine production involved in immune response (GO:0002367)2.82930341
108positive regulation of protein import into nucleus, translocation (GO:0033160)2.80066777
109embryonic process involved in female pregnancy (GO:0060136)2.79784824
110formation of translation preinitiation complex (GO:0001731)2.79714627
111regulation of gamma-delta T cell activation (GO:0046643)2.78843514
112folic acid metabolic process (GO:0046655)2.78735624
113valine metabolic process (GO:0006573)2.78670341
114regulation of response to osmotic stress (GO:0047484)2.78156591
1153-UTR-mediated mRNA stabilization (GO:0070935)2.78059183
116aggressive behavior (GO:0002118)2.77060011
117mRNA transcription from RNA polymerase II promoter (GO:0042789)2.74547213
118negative regulation of cell size (GO:0045792)2.74137656
119lymph vessel development (GO:0001945)2.70173317
120regulation of histone H3-K4 methylation (GO:0051569)2.69415649
121phenol-containing compound catabolic process (GO:0019336)2.67913303
122tyrosine phosphorylation of STAT protein (GO:0007260)2.67506431
123negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.65876434
124regulation of monocyte differentiation (GO:0045655)2.65826106
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65732713
126germ cell migration (GO:0008354)2.65351882
127pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.65242786
128tricarboxylic acid metabolic process (GO:0072350)2.64834626
129ribonucleoprotein complex biogenesis (GO:0022613)2.64660001
130DNA strand elongation involved in DNA replication (GO:0006271)2.63645707
131telomere maintenance via semi-conservative replication (GO:0032201)2.63512982
132deoxyribose phosphate catabolic process (GO:0046386)2.63398199
133DNA strand elongation (GO:0022616)2.62378281
134regulation of histone H3-K27 methylation (GO:0061085)2.61990749
135glucose catabolic process (GO:0006007)2.61964954
136ribosome biogenesis (GO:0042254)2.61928065
137deoxyribonucleotide catabolic process (GO:0009264)2.61893607
138angiogenesis involved in wound healing (GO:0060055)2.60596700
139regulation of mast cell activation involved in immune response (GO:0033006)2.60497642
140platelet aggregation (GO:0070527)2.59970156
141blood vessel maturation (GO:0001955)2.59914820
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59276389
143NADPH regeneration (GO:0006740)2.58552698
144IMP metabolic process (GO:0046040)2.58104378
145positive regulation of mast cell degranulation (GO:0043306)2.57862983
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.57862983
147platelet formation (GO:0030220)2.57011848
148regulation of RNA export from nucleus (GO:0046831)2.56829600
149regulation of integrin activation (GO:0033623)2.55768774
150pinocytosis (GO:0006907)2.54665004
151negative regulation of RNA splicing (GO:0033119)2.54599634
152DNA unwinding involved in DNA replication (GO:0006268)2.53827806
153positive regulation of natural killer cell activation (GO:0032816)2.53518463
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53200632
155grooming behavior (GO:0007625)2.52990591
156autophagic vacuole fusion (GO:0000046)2.52612649
157negative regulation of gene expression, epigenetic (GO:0045814)2.52427835
158negative regulation of biomineral tissue development (GO:0070168)2.48129284
159regulation of histone methylation (GO:0031060)2.47996017
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47241361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.09553942
2* SCL_19346495_ChIP-Seq_HPC-7_Human5.04282854
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18807542
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16100451
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10735456
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.91284432
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.84893365
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.80407404
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.80238241
10* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.77791786
11GATA1_22025678_ChIP-Seq_K562_Human2.77563890
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.69877287
13MYC_22102868_ChIP-Seq_BL_Human2.60734591
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49717270
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34267190
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23442466
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22503312
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.18665443
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17936684
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.08001635
21* SPI1_23547873_ChIP-Seq_NB4_Human2.05169689
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02119711
23VDR_21846776_ChIP-Seq_THP-1_Human2.01923480
24GATA1_22383799_ChIP-Seq_G1ME_Mouse1.98086379
25* TCF7_22412390_ChIP-Seq_EML_Mouse1.96524322
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.95959607
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93935750
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93453228
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92818758
30* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.92429440
31* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91475396
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90725127
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.85265131
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81562424
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81410134
36* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77362436
37* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77044267
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75538072
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74457066
40CIITA_25753668_ChIP-Seq_RAJI_Human1.74298330
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69540961
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69263802
43* LXR_22292898_ChIP-Seq_THP-1_Human1.65527770
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64011704
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63885858
46VDR_24763502_ChIP-Seq_THP-1_Human1.63245004
47* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61895519
48MAF_26560356_Chip-Seq_TH1_Human1.61787289
49* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.61570570
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.60211273
51* GATA1_19941827_ChIP-Seq_MEL_Mouse1.57748009
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57657894
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.56799747
54KDM5A_27292631_Chip-Seq_BREAST_Human1.55989039
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.53581394
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53201289
57FOXP3_21729870_ChIP-Seq_TREG_Human1.50918283
58VDR_23849224_ChIP-Seq_CD4+_Human1.48823641
59* XRN2_22483619_ChIP-Seq_HELA_Human1.47964006
60* UTX_26944678_Chip-Seq_JUKART_Human1.46993949
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.46944518
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46164674
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.44349786
64KDM2B_26808549_Chip-Seq_DND41_Human1.43429976
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.43334523
66P68_20966046_ChIP-Seq_HELA_Human1.43236661
67MYB_26560356_Chip-Seq_TH1_Human1.42970986
68MYB_26560356_Chip-Seq_TH2_Human1.41896270
69RACK7_27058665_Chip-Seq_MCF-7_Human1.41593774
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40129043
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38967592
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.38786277
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38147769
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35356449
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.35352391
76* GATA2_19941826_ChIP-Seq_K562_Human1.31257141
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30748166
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30284740
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29611570
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28623963
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25354343
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25148745
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24715612
84RUNX_20019798_ChIP-Seq_JUKART_Human1.24597558
85NCOR1_26117541_ChIP-Seq_K562_Human1.24574584
86TTF2_22483619_ChIP-Seq_HELA_Human1.23679025
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.23258990
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23179620
89* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22825484
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.20873942
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20609829
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18882048
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.18097633
94IRF1_19129219_ChIP-ChIP_H3396_Human1.17914668
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17798957
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16968240
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16816004
98SPI1_23127762_ChIP-Seq_K562_Human1.16516994
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16254941
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15642468
101ZNF263_19887448_ChIP-Seq_K562_Human1.15359442
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14985792
103GABP_19822575_ChIP-Seq_HepG2_Human1.14177928
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.14025603
105CHD1_26751641_Chip-Seq_LNCaP_Human1.13461401
106SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12748566
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12190562
108* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07909405
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.07822311
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07088231
111ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06920508
112MAF_26560356_Chip-Seq_TH2_Human1.05603578
113AR_21909140_ChIP-Seq_LNCAP_Human1.04607008
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04276814
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04217754
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04047919
117BCOR_27268052_Chip-Seq_Bcells_Human1.01873902
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01819583
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01483685
120* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01340773
121CTCF_21964334_Chip-Seq_Bcells_Human0.99322301
122ELK1_19687146_ChIP-ChIP_HELA_Human0.98071288
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97534725
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97433586
125RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96982784
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96181396
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95815295
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95557051
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94681427
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90453821
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90221216
132DCP1A_22483619_ChIP-Seq_HELA_Human0.89089073
133GATA1_19941826_ChIP-Seq_K562_Human0.88991269
134CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88494983
135FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86670531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.55632480
2MP0002009_preneoplasia4.21790168
3MP0004808_abnormal_hematopoietic_stem3.91642292
4MP0001545_abnormal_hematopoietic_system3.47229800
5MP0005397_hematopoietic_system_phenotyp3.47229800
6MP0000465_gastrointestinal_hemorrhage3.22790057
7MP0002822_catalepsy3.20168692
8MP0004147_increased_porphyrin_level2.98635629
9MP0005174_abnormal_tail_pigmentation2.95202495
10MP0005464_abnormal_platelet_physiology2.87226150
11MP0005075_abnormal_melanosome_morpholog2.47420455
12MP0005451_abnormal_body_composition2.47341694
13MP0006054_spinal_hemorrhage2.45125574
14MP0003724_increased_susceptibility_to2.40623774
15MP0009278_abnormal_bone_marrow2.31789949
16MP0003315_abnormal_perineum_morphology2.14322918
17MP0004185_abnormal_adipocyte_glucose2.06919694
18MP0000490_abnormal_crypts_of2.05071821
19MP0010368_abnormal_lymphatic_system1.99103105
20* MP0002398_abnormal_bone_marrow1.91167026
21MP0003943_abnormal_hepatobiliary_system1.90128654
22MP0004233_abnormal_muscle_weight1.85575621
23MP0001835_abnormal_antigen_presentation1.84554335
24MP0002877_abnormal_melanocyte_morpholog1.82949310
25MP0008007_abnormal_cellular_replicative1.82062911
26MP0000537_abnormal_urethra_morphology1.69791922
27MP0005671_abnormal_response_to1.66015810
28MP0004858_abnormal_nervous_system1.65150768
29MP0002166_altered_tumor_susceptibility1.65000766
30MP0002132_abnormal_respiratory_system1.64737776
31MP0009379_abnormal_foot_pigmentation1.64387092
32MP0003693_abnormal_embryo_hatching1.61597938
33MP0010094_abnormal_chromosome_stability1.61499165
34MP0003567_abnormal_fetal_cardiomyocyte1.59919712
35MP0004145_abnormal_muscle_electrophysio1.57762319
36MP0002722_abnormal_immune_system1.57685267
37MP0005666_abnormal_adipose_tissue1.56637856
38MP0010352_gastrointestinal_tract_polyps1.55108563
39MP0003656_abnormal_erythrocyte_physiolo1.54206012
40MP0000689_abnormal_spleen_morphology1.53493771
41MP0000685_abnormal_immune_system1.51741578
42MP0005025_abnormal_response_to1.51121075
43MP0003718_maternal_effect1.50556949
44MP0001873_stomach_inflammation1.50202868
45* MP0002429_abnormal_blood_cell1.49972230
46MP0002095_abnormal_skin_pigmentation1.46273747
47MP0001730_embryonic_growth_arrest1.45377488
48MP0003303_peritoneal_inflammation1.44272494
49MP0003111_abnormal_nucleus_morphology1.43448021
50MP0000716_abnormal_immune_system1.42829448
51MP0003866_abnormal_defecation1.42655814
52MP0003077_abnormal_cell_cycle1.41778541
53MP0005076_abnormal_cell_differentiation1.40108803
54MP0003763_abnormal_thymus_physiology1.39593439
55MP0009785_altered_susceptibility_to1.39363289
56MP0004264_abnormal_extraembryonic_tissu1.39262215
57MP0010155_abnormal_intestine_physiology1.38183009
58MP0002420_abnormal_adaptive_immunity1.38071516
59MP0000681_abnormal_thyroid_gland1.37546154
60MP0001819_abnormal_immune_cell1.36291531
61MP0001188_hyperpigmentation1.35650846
62MP0001853_heart_inflammation1.35436078
63MP0008004_abnormal_stomach_pH1.31731987
64MP0005375_adipose_tissue_phenotype1.29434050
65MP0004957_abnormal_blastocyst_morpholog1.28564876
66MP0000343_altered_response_to1.27205200
67MP0008057_abnormal_DNA_replication1.26227147
68MP0003436_decreased_susceptibility_to1.25376811
69MP0002452_abnormal_antigen_presenting1.25355736
70MP0002723_abnormal_immune_serum1.24265382
71MP0001879_abnormal_lymphatic_vessel1.23758326
72MP0003566_abnormal_cell_adhesion1.23026804
73MP0005645_abnormal_hypothalamus_physiol1.22813073
74MP0005670_abnormal_white_adipose1.18279891
75MP0000703_abnormal_thymus_morphology1.18257073
76MP0003806_abnormal_nucleotide_metabolis1.17473031
77MP0001800_abnormal_humoral_immune1.17174706
78MP0002148_abnormal_hypersensitivity_rea1.16378166
79MP0002419_abnormal_innate_immunity1.14620220
80MP0002088_abnormal_embryonic_growth/wei1.12567890
81MP0009333_abnormal_splenocyte_physiolog1.11815802
82MP0000003_abnormal_adipose_tissue1.11669053
83MP0001881_abnormal_mammary_gland1.11223130
84MP0000678_abnormal_parathyroid_gland1.10835367
85MP0002019_abnormal_tumor_incidence1.09452894
86MP0000313_abnormal_cell_death1.08234443
87MP0005380_embryogenesis_phenotype1.07888480
88MP0001672_abnormal_embryogenesis/_devel1.07888480
89MP0003828_pulmonary_edema1.07762286
90MP0008961_abnormal_basal_metabolism1.07592406
91MP0009697_abnormal_copulation1.07321197
92MP0005000_abnormal_immune_tolerance1.05858693
93MP0001697_abnormal_embryo_size1.05474322
94MP0003186_abnormal_redox_activity1.04948960
95MP0003279_aneurysm1.04649766
96MP0001664_abnormal_digestion1.03962535
97MP0008995_early_reproductive_senescence1.03192410
98MP0002006_tumorigenesis1.02892867
99MP0001348_abnormal_lacrimal_gland1.02742990
100MP0009931_abnormal_skin_appearance1.02153644
101MP0008932_abnormal_embryonic_tissue1.00735265
102MP0003638_abnormal_response/metabolism_0.99662553
103MP0005647_abnormal_sex_gland0.98792914
104MP0006036_abnormal_mitochondrial_physio0.95000732
105MP0002405_respiratory_system_inflammati0.94835766
106MP0005501_abnormal_skin_physiology0.94464416
107MP0010307_abnormal_tumor_latency0.94363189
108MP0001764_abnormal_homeostasis0.94206814
109MP0005409_darkened_coat_color0.94082773
110MP0001661_extended_life_span0.92390557
111MP0000858_altered_metastatic_potential0.91707523
112MP0003300_gastrointestinal_ulcer0.91608260
113MP0010630_abnormal_cardiac_muscle0.90519696
114* MP0002086_abnormal_extraembryonic_tissu0.90078042
115MP0006292_abnormal_olfactory_placode0.87304766
116MP0003705_abnormal_hypodermis_morpholog0.86097861
117MP0000613_abnormal_salivary_gland0.85743991
118MP0001845_abnormal_inflammatory_respons0.84639618
119MP0003868_abnormal_feces_composition0.83685386
120MP0005636_abnormal_mineral_homeostasis0.83454720
121MP0005083_abnormal_biliary_tract0.82675568
122MP0008058_abnormal_DNA_repair0.82187121
123MP0006138_congestive_heart_failure0.81988148
124MP0008469_abnormal_protein_level0.81757339
125MP0008775_abnormal_heart_ventricle0.81683961
126MP0002128_abnormal_blood_circulation0.81597820
127MP0000249_abnormal_blood_vessel0.80562391
128MP0004782_abnormal_surfactant_physiolog0.79351347
129MP0003191_abnormal_cellular_cholesterol0.78927517
130MP0008260_abnormal_autophagy0.77973100
131MP0009764_decreased_sensitivity_to0.75189240
132MP0001533_abnormal_skeleton_physiology0.74021258
133MP0000477_abnormal_intestine_morphology0.73838727
134MP0002796_impaired_skin_barrier0.72950165
135MP0000538_abnormal_urinary_bladder0.71651828
136MP0000767_abnormal_smooth_muscle0.71159075
137MP0003959_abnormal_lean_body0.71156296
138MP0003786_premature_aging0.70331346
139MP0005310_abnormal_salivary_gland0.69967585
140MP0000015_abnormal_ear_pigmentation0.69268268
141MP0001790_abnormal_immune_system0.69169696
142MP0005387_immune_system_phenotype0.69169696
143MP0005220_abnormal_exocrine_pancreas0.69158820
144* MP0002080_prenatal_lethality0.68930377
145MP0000350_abnormal_cell_proliferation0.68760808
146MP0003984_embryonic_growth_retardation0.68568326
147MP0000598_abnormal_liver_morphology0.66468175
148MP0002089_abnormal_postnatal_growth/wei0.66353485
149MP0005167_abnormal_blood-brain_barrier0.65318720
150MP0005621_abnormal_cell_physiology0.64697918
151MP0002160_abnormal_reproductive_system0.62808198
152MP0004947_skin_inflammation0.60434007

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)6.99164613
2Prolonged bleeding time (HP:0003010)6.74088417
3Hyperthyroidism (HP:0000836)5.61046782
4Thrombocytosis (HP:0001894)5.53497777
5Abnormality of the heme biosynthetic pathway (HP:0010472)5.45314993
6Abnormality of cells of the erythroid lineage (HP:0012130)5.34801597
7Abnormal number of erythroid precursors (HP:0012131)5.30934503
8Seborrheic dermatitis (HP:0001051)5.01408326
9Impaired platelet aggregation (HP:0003540)4.94874552
10Abnormal platelet function (HP:0011869)4.94874552
11Truncus arteriosus (HP:0001660)4.82143786
12Epistaxis (HP:0000421)4.37258590
13Reticulocytopenia (HP:0001896)4.25258760
14Chronic otitis media (HP:0000389)4.23322629
15Purpura (HP:0000979)4.20010547
16Hypertensive crisis (HP:0100735)4.10267905
17Menorrhagia (HP:0000132)4.07666283
18Reticulocytosis (HP:0001923)4.05893550
19Abnormal platelet volume (HP:0011876)3.93701610
20Hypoparathyroidism (HP:0000829)3.68383018
21Increased mean platelet volume (HP:0011877)3.63354370
22* Aplastic anemia (HP:0001915)3.56524035
23IgM deficiency (HP:0002850)3.56054159
24Reduced antithrombin III activity (HP:0001976)3.52078045
25Abnormality of the tricuspid valve (HP:0001702)3.41284983
26Gingival bleeding (HP:0000225)3.33808897
27Acute myeloid leukemia (HP:0004808)3.31150519
28Atelectasis (HP:0100750)3.29364828
29Testicular atrophy (HP:0000029)3.27425449
30Sparse lateral eyebrow (HP:0005338)3.19268911
31Abnormality of the parathyroid morphology (HP:0011766)3.15634899
32* Pallor (HP:0000980)3.14474319
33Abnormality of the nasal mucosa (HP:0000433)3.06778083
34Obstructive lung disease (HP:0006536)3.04071155
35Chronic obstructive pulmonary disease (HP:0006510)3.04071155
36Aplasia/Hypoplasia of the thymus (HP:0010515)2.87572086
37Type I transferrin isoform profile (HP:0003642)2.86319886
38Spontaneous hematomas (HP:0007420)2.85326772
39Bowel incontinence (HP:0002607)2.80090998
40Orthostatic hypotension (HP:0001278)2.78913911
41Progressive muscle weakness (HP:0003323)2.71448247
42Abnormally folded helix (HP:0008544)2.69810891
43Abnormal large intestine physiology (HP:0012700)2.68606439
44Albinism (HP:0001022)2.64660527
45Septate vagina (HP:0001153)2.62652028
46* Myelodysplasia (HP:0002863)2.61033614
47Patellar dislocation (HP:0002999)2.59950694
48Patchy hypopigmentation of hair (HP:0011365)2.59620300
49White forelock (HP:0002211)2.57085564
50Muscle fiber atrophy (HP:0100295)2.42430591
51Facial diplegia (HP:0001349)2.41277362
52Paralysis (HP:0003470)2.41276898
53Recurrent bronchitis (HP:0002837)2.41268470
54Amaurosis fugax (HP:0100576)2.40610943
55Prostate neoplasm (HP:0100787)2.40199196
5611 pairs of ribs (HP:0000878)2.38214321
57Macrocytic anemia (HP:0001972)2.37476794
58* Bruising susceptibility (HP:0000978)2.37443061
59Microcytic anemia (HP:0001935)2.36679946
60Premature skin wrinkling (HP:0100678)2.36532103
61Overfolded helix (HP:0000396)2.36113544
62Acute lymphatic leukemia (HP:0006721)2.35148677
63Disproportionate tall stature (HP:0001519)2.31163232
64Type 2 muscle fiber atrophy (HP:0003554)2.31112635
65Abnormality of iron homeostasis (HP:0011031)2.29467347
66Elevated erythrocyte sedimentation rate (HP:0003565)2.26168175
67Hyperammonemia (HP:0001987)2.25953102
68Abnormality of transition element cation homeostasis (HP:0011030)2.25812119
69Nasal polyposis (HP:0100582)2.24271313
70Multiple enchondromatosis (HP:0005701)2.21418248
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21066219
72Abnormal protein N-linked glycosylation (HP:0012347)2.21066219
73Abnormal protein glycosylation (HP:0012346)2.21066219
74Abnormal glycosylation (HP:0012345)2.21066219
75Colon cancer (HP:0003003)2.20628240
76Chronic sinusitis (HP:0011109)2.20621742
77Cerebral palsy (HP:0100021)2.20102766
78Aortic aneurysm (HP:0004942)2.18333009
79Short 5th finger (HP:0009237)2.18075418
80Radial bowing (HP:0002986)2.18049802
81Microvesicular hepatic steatosis (HP:0001414)2.17866281
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.17565472
83Short middle phalanx of the 5th finger (HP:0004220)2.17250057
84Shawl scrotum (HP:0000049)2.14875317
85Fatigue (HP:0012378)2.14612674
86Asplenia (HP:0001746)2.13561273
87Depressed nasal tip (HP:0000437)2.11046212
88Myositis (HP:0100614)2.10729454
89Hematochezia (HP:0002573)2.09794920
90Venous insufficiency (HP:0005293)2.09256473
91Centrally nucleated skeletal muscle fibers (HP:0003687)2.08312786
92Abnormality of the thymus (HP:0000777)2.05261010
93Acanthocytosis (HP:0001927)2.03920044
94Weak cry (HP:0001612)2.03049209
95Increased muscle lipid content (HP:0009058)2.02918542
96Venous abnormality (HP:0002624)2.00965485
97Pili torti (HP:0003777)2.00952004
98Cholecystitis (HP:0001082)1.99050771
99Abnormal gallbladder physiology (HP:0012438)1.99050771
100Urethral obstruction (HP:0000796)1.98693828
101Aplasia/Hypoplasia of the spleen (HP:0010451)1.97460349
102Neoplasm of head and neck (HP:0012288)1.95791203
103Esophageal neoplasm (HP:0100751)1.95791203
104Chest pain (HP:0100749)1.94536670
105Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93379279
106Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.91950506
107Thoracic kyphosis (HP:0002942)1.89692504
108Abnormality of the fingertips (HP:0001211)1.89389955
109Blepharitis (HP:0000498)1.88950595
110Long eyelashes (HP:0000527)1.88574131
111Short 1st metacarpal (HP:0010034)1.86599795
112Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86599795
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85318979
114Interstitial pulmonary disease (HP:0006530)1.85178606
115Abnormality of the 1st metacarpal (HP:0010009)1.83679378
116Cholelithiasis (HP:0001081)1.83178027
117Growth hormone excess (HP:0000845)1.82116053
118Intestinal malrotation (HP:0002566)1.80111887
119Hypoplasia of the thymus (HP:0000778)1.79773006
120Abnormality of reticulocytes (HP:0004312)1.78946883
121Abnormality of the prostate (HP:0008775)1.77970816
122Partial agenesis of the corpus callosum (HP:0001338)1.77334729
123Hepatosplenomegaly (HP:0001433)1.77045325
124Polycythemia (HP:0001901)1.76995981
125Neonatal hypoglycemia (HP:0001998)1.76789876
126Coarctation of aorta (HP:0001680)1.76624744
127Vacuolated lymphocytes (HP:0001922)1.76471966
128Beaking of vertebral bodies (HP:0004568)1.75619298
129Abnormal autonomic nervous system physiology (HP:0012332)1.75298103
130Abnormality of dental color (HP:0011073)1.75245046
131Abnormality of the thoracic spine (HP:0100711)1.74563461
132Birth length less than 3rd percentile (HP:0003561)1.73497689
133Abnormality of the fetal cardiovascular system (HP:0010948)1.73250739
134Abnormal umbilical cord blood vessels (HP:0011403)1.73250739
135Single umbilical artery (HP:0001195)1.73250739
136Increased cerebral lipofuscin (HP:0011813)1.72055238
137Anteriorly placed anus (HP:0001545)1.71700807
138Annular pancreas (HP:0001734)1.71418410
139Ragged-red muscle fibers (HP:0003200)1.71186313
140Homocystinuria (HP:0002156)1.71095610
141Abnormality of homocysteine metabolism (HP:0010919)1.71095610
142Polycystic kidney dysplasia (HP:0000113)1.70723133
143Selective tooth agenesis (HP:0001592)1.70293298
144Nonprogressive disorder (HP:0003680)1.69618436
145Short clavicles (HP:0000894)1.69546519
146Abnormality of T cell physiology (HP:0011840)1.69413204
147Gonadotropin excess (HP:0000837)1.69231248
148Spinal cord lesions (HP:0100561)1.69210710
149Syringomyelia (HP:0003396)1.69210710
150Microretrognathia (HP:0000308)1.68501068
151Redundant skin (HP:0001582)1.68369518
152Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.68090164
153Abnormality of the columella (HP:0009929)1.67861948
154Abnormality of lateral ventricle (HP:0030047)1.67640606
155Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67356295
156Volvulus (HP:0002580)1.67340547
157Increased serum ferritin (HP:0003281)1.66694220
158Gastrointestinal inflammation (HP:0004386)1.66574435
159Limb hypertonia (HP:0002509)1.66565136
160Poikiloderma (HP:0001029)1.66383542
161Abnormality of secondary sexual hair (HP:0009888)1.66053110
162Abnormality of the axillary hair (HP:0100134)1.66053110
163Anal stenosis (HP:0002025)1.65813694
164Poikilocytosis (HP:0004447)1.65674446
165Hypothermia (HP:0002045)1.64795446
166* Cellulitis (HP:0100658)1.64653484
167Broad palm (HP:0001169)1.64570222
168Easy fatigability (HP:0003388)1.63031087
169* Pancytopenia (HP:0001876)1.62690177
170Arterial thrombosis (HP:0004420)1.61452106
171Abnormal delayed hypersensitivity skin test (HP:0002963)1.61187532
172Congenital, generalized hypertrichosis (HP:0004540)1.60158558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.89470184
2TIE13.59148205
3MATK3.02380972
4KIT2.90302646
5TAOK32.87680094
6NME22.87145474
7TGFBR12.58822955
8RPS6KB22.42945645
9TESK22.39451932
10MAPKAPK52.24865689
11BTK2.16940133
12MAP2K32.15303956
13PIM22.15020669
14MAP4K12.09488005
15IRAK32.08889387
16TGFBR22.08649330
17WEE12.07965664
18CAMK1D2.07721712
19STK162.07289337
20EIF2AK12.01685558
21ICK1.89484294
22SMG11.85440556
23CDK121.84462881
24MYLK1.80702426
25JAK31.76717398
26PLK41.74183546
27MAPKAPK31.69935269
28PRPF4B1.64703174
29PKN21.63814316
30KDR1.63469429
31TAOK11.56644229
32DYRK31.54315504
33IRAK41.50425885
34TEC1.46463734
35ERN11.46116801
36VRK21.45322174
37AKT31.41817947
38MUSK1.39930556
39TAOK21.39676388
40LRRK21.36331483
41CDK191.34164548
42CAMK1G1.34133485
43MAP3K121.34045759
44CDK81.29978682
45PRKD21.26709290
46RIPK41.26123714
47MKNK11.23045902
48BCKDK1.20454018
49TRPM71.19111290
50LATS11.19010459
51CDK71.16624766
52MTOR1.15102696
53ACVR1B1.10249607
54CSF1R1.09565162
55MAP3K61.09261590
56TBK11.08477558
57PBK1.06860681
58PRKD31.05973744
59MARK21.05727998
60FLT31.05588708
61FER1.05528631
62ZAP701.04961011
63PIM11.04275318
64PAK41.04099377
65TNK21.03640287
66RPS6KA41.03200035
67TRIB31.02640076
68PRKG21.02009281
69BRSK21.01971483
70NME10.94362903
71MAP3K10.94064131
72NEK20.93413862
73STK100.92286583
74CHEK20.90090140
75SYK0.88286215
76WNK40.82160674
77GRK60.81632203
78ATR0.80953215
79PAK20.80091049
80VRK10.77933825
81SIK10.76299583
82IKBKE0.74811883
83PASK0.73432386
84MKNK20.73169803
85NUAK10.71610534
86MAP2K20.70087906
87PTK60.69848653
88CCNB10.69199296
89CLK10.68765009
90AURKA0.68479417
91ILK0.68054586
92TYK20.67267322
93RPS6KA60.66130180
94CDK40.65132653
95MAPK40.64870405
96MAP3K110.64784869
97STK30.64444658
98SCYL20.64205194
99HIPK20.63832004
100PIK3CG0.60299188
101LYN0.59710603
102IKBKB0.58753876
103CAMK10.58686021
104RPS6KC10.57430901
105RPS6KL10.57430901
106IRAK20.56863147
107BMX0.56557003
108CAMKK20.53902367
109CDK20.53240006
110TNIK0.52901838
111MAPK30.52790229
112CDK60.52746317
113TXK0.52420997
114RPS6KA20.52177971
115CDC70.51553894
116TSSK60.50300270
117CHEK10.50174770
118BUB10.49141670
119BRD40.47799410
120CDK90.47319189
121GRK10.46669022
122DAPK10.46326520
123STK240.45247651
124MAP3K70.44839665
125PDK20.44665090
126LCK0.44644562
127JAK20.44262649
128FES0.43802890
129RAF10.43700297
130RET0.43044298
131AURKB0.42693796
132MAPKAPK20.41736641
133MAP3K80.41470617
134LATS20.39820901
135MAP3K30.38800283
136SRPK10.38728064
137* AKT10.37798689
138AKT20.37542108
139DAPK20.37254631
140FGFR30.37212969
141MAPK110.35717328
142ABL20.35046465
143MAP2K10.34627935
144RIPK10.34577318
145HCK0.33255759
146BMPR20.33101997
147RPS6KA50.33049624
148MAPK10.32920239
149MAP3K100.31700260
150MAP2K60.31209666

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.70116585
2DNA replication_Homo sapiens_hsa030303.63295247
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.85277163
4Mismatch repair_Homo sapiens_hsa034302.22586915
5Base excision repair_Homo sapiens_hsa034102.16639582
6Platelet activation_Homo sapiens_hsa046112.13057513
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90761183
8Homologous recombination_Homo sapiens_hsa034401.86625499
9N-Glycan biosynthesis_Homo sapiens_hsa005101.83550625
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.81089713
11Spliceosome_Homo sapiens_hsa030401.80645782
12Fatty acid biosynthesis_Homo sapiens_hsa000611.79854817
13Pyrimidine metabolism_Homo sapiens_hsa002401.77670882
14Hematopoietic cell lineage_Homo sapiens_hsa046401.75055882
15Asthma_Homo sapiens_hsa053101.70585159
16Cell cycle_Homo sapiens_hsa041101.63705160
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63444899
18Renin-angiotensin system_Homo sapiens_hsa046141.57722708
19Herpes simplex infection_Homo sapiens_hsa051681.55891724
20Acute myeloid leukemia_Homo sapiens_hsa052211.55155695
21Leishmaniasis_Homo sapiens_hsa051401.54044201
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53873432
23RNA polymerase_Homo sapiens_hsa030201.50990717
24Nucleotide excision repair_Homo sapiens_hsa034201.48200458
25RNA degradation_Homo sapiens_hsa030181.47754267
26Protein export_Homo sapiens_hsa030601.47574722
27Bladder cancer_Homo sapiens_hsa052191.44753313
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41999596
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40517769
30Biosynthesis of amino acids_Homo sapiens_hsa012301.37934968
31B cell receptor signaling pathway_Homo sapiens_hsa046621.37854748
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33300317
33Chronic myeloid leukemia_Homo sapiens_hsa052201.32968795
34Carbon metabolism_Homo sapiens_hsa012001.32615591
35RNA transport_Homo sapiens_hsa030131.30881720
36Measles_Homo sapiens_hsa051621.30361556
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23608844
38Fatty acid metabolism_Homo sapiens_hsa012121.23192655
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20938807
40Other glycan degradation_Homo sapiens_hsa005111.19542373
41Small cell lung cancer_Homo sapiens_hsa052221.17112938
42Non-homologous end-joining_Homo sapiens_hsa034501.16417428
43Hepatitis B_Homo sapiens_hsa051611.15243298
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.13178169
45Thyroid cancer_Homo sapiens_hsa052161.12540642
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12519390
47Shigellosis_Homo sapiens_hsa051311.08790460
48mTOR signaling pathway_Homo sapiens_hsa041501.05936883
49p53 signaling pathway_Homo sapiens_hsa041151.05268783
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03131583
51Antigen processing and presentation_Homo sapiens_hsa046121.01887474
52One carbon pool by folate_Homo sapiens_hsa006701.00994260
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.99351964
54Fanconi anemia pathway_Homo sapiens_hsa034600.97140048
55Caffeine metabolism_Homo sapiens_hsa002320.97075626
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96557914
57Basal transcription factors_Homo sapiens_hsa030220.93536289
58Folate biosynthesis_Homo sapiens_hsa007900.92999002
59Inositol phosphate metabolism_Homo sapiens_hsa005620.92294714
60Toxoplasmosis_Homo sapiens_hsa051450.92183066
61Legionellosis_Homo sapiens_hsa051340.90695707
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.90679516
63Apoptosis_Homo sapiens_hsa042100.88686513
64Sulfur relay system_Homo sapiens_hsa041220.87478214
65Non-small cell lung cancer_Homo sapiens_hsa052230.84744791
66Influenza A_Homo sapiens_hsa051640.84496388
67Purine metabolism_Homo sapiens_hsa002300.84339121
68VEGF signaling pathway_Homo sapiens_hsa043700.84328974
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84315628
70Glutathione metabolism_Homo sapiens_hsa004800.83638476
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83327252
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80752329
73Osteoclast differentiation_Homo sapiens_hsa043800.79197222
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78349838
75Pertussis_Homo sapiens_hsa051330.77907710
76Lysine degradation_Homo sapiens_hsa003100.77377067
77Primary immunodeficiency_Homo sapiens_hsa053400.76502418
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75804250
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75378627
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.75103045
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74101393
82Viral carcinogenesis_Homo sapiens_hsa052030.72510270
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.70725912
84HTLV-I infection_Homo sapiens_hsa051660.70392895
85ECM-receptor interaction_Homo sapiens_hsa045120.70003822
86Pyruvate metabolism_Homo sapiens_hsa006200.69538952
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68869862
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68571304
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.67827142
90Prostate cancer_Homo sapiens_hsa052150.67549739
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67382133
92mRNA surveillance pathway_Homo sapiens_hsa030150.67256090
93Prolactin signaling pathway_Homo sapiens_hsa049170.65642226
94Arachidonic acid metabolism_Homo sapiens_hsa005900.64738280
95TNF signaling pathway_Homo sapiens_hsa046680.62832184
96Fructose and mannose metabolism_Homo sapiens_hsa000510.62635247
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.62576575
98Pathways in cancer_Homo sapiens_hsa052000.62183181
99AMPK signaling pathway_Homo sapiens_hsa041520.61434761
100Endometrial cancer_Homo sapiens_hsa052130.60522266
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59333912
102Galactose metabolism_Homo sapiens_hsa000520.59032166
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58831106
104Tyrosine metabolism_Homo sapiens_hsa003500.56640309
105Vitamin digestion and absorption_Homo sapiens_hsa049770.55481972
106Pancreatic cancer_Homo sapiens_hsa052120.55359110
107ErbB signaling pathway_Homo sapiens_hsa040120.54898874
108Notch signaling pathway_Homo sapiens_hsa043300.54804483
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53666629
110Selenocompound metabolism_Homo sapiens_hsa004500.52933112
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.52309413
112Epstein-Barr virus infection_Homo sapiens_hsa051690.51835153
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51486108
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50637318
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.50170951
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50110820
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50023956
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49908802
119Pentose phosphate pathway_Homo sapiens_hsa000300.47827267
120Salmonella infection_Homo sapiens_hsa051320.47559821
121Focal adhesion_Homo sapiens_hsa045100.47090611
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45186376
123Hepatitis C_Homo sapiens_hsa051600.45116137
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44803008
125HIF-1 signaling pathway_Homo sapiens_hsa040660.43909832
126Insulin signaling pathway_Homo sapiens_hsa049100.43125408
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42426044
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42143064
129Ovarian steroidogenesis_Homo sapiens_hsa049130.40057751
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38994496
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38460085
132Amoebiasis_Homo sapiens_hsa051460.38129235
133MicroRNAs in cancer_Homo sapiens_hsa052060.37945904
134Fatty acid elongation_Homo sapiens_hsa000620.37857142
135Endocytosis_Homo sapiens_hsa041440.37803520
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36290970
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.36101063
138Colorectal cancer_Homo sapiens_hsa052100.34519980
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34391381
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34060944

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