GATA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.70954674
2regulation of water loss via skin (GO:0033561)8.17775235
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)8.07772955
4ribosomal small subunit biogenesis (GO:0042274)7.90245069
5viral transcription (GO:0019083)7.67050443
6keratinocyte development (GO:0003334)7.36703185
7translational termination (GO:0006415)7.31341811
8maturation of SSU-rRNA (GO:0030490)6.26938156
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.05660168
10ribosomal small subunit assembly (GO:0000028)5.98710838
11cotranslational protein targeting to membrane (GO:0006613)5.94137183
12protein targeting to ER (GO:0045047)5.93826791
13translational elongation (GO:0006414)5.90138665
14viral life cycle (GO:0019058)5.74754765
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.69072346
16protein localization to endoplasmic reticulum (GO:0070972)5.61440864
17cellular protein complex disassembly (GO:0043624)5.59477620
18vagina development (GO:0060068)5.59228065
19sphingoid metabolic process (GO:0046519)5.50309120
20keratinocyte proliferation (GO:0043616)5.45582881
21cyclooxygenase pathway (GO:0019371)5.45128204
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.44296242
23multicellular organismal water homeostasis (GO:0050891)5.35038794
24negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)5.15486100
25positive regulation of Cdc42 GTPase activity (GO:0043089)5.06958213
26translational initiation (GO:0006413)5.01120262
27maternal placenta development (GO:0001893)4.96671996
28prostanoid biosynthetic process (GO:0046457)4.93355216
29prostaglandin biosynthetic process (GO:0001516)4.93355216
30glucosamine-containing compound catabolic process (GO:1901072)4.90536982
31negative regulation of cell size (GO:0045792)4.90138438
32hemidesmosome assembly (GO:0031581)4.86429895
33amino sugar catabolic process (GO:0046348)4.80496793
34branching involved in mammary gland duct morphogenesis (GO:0060444)4.78537122
35ribosomal large subunit biogenesis (GO:0042273)4.78197911
36COPI coating of Golgi vesicle (GO:0048205)4.75676348
37Golgi transport vesicle coating (GO:0048200)4.75676348
38intestinal epithelial cell development (GO:0060576)4.75153976
39protein complex disassembly (GO:0043241)4.73016971
40cell differentiation involved in embryonic placenta development (GO:0060706)4.56357204
41water homeostasis (GO:0030104)4.48165125
42regulation of chemokine secretion (GO:0090196)4.45178089
43sphingosine metabolic process (GO:0006670)4.41525855
44macromolecular complex disassembly (GO:0032984)4.37030281
45keratinocyte differentiation (GO:0030216)4.35384523
46keratinization (GO:0031424)4.26046207
47diol metabolic process (GO:0034311)4.24657885
48mammary gland epithelial cell differentiation (GO:0060644)4.24269519
49embryonic camera-type eye morphogenesis (GO:0048596)4.22174925
50female genitalia development (GO:0030540)4.21682253
51negative regulation of cell fate specification (GO:0009996)4.18121323
52negative regulation of cell fate commitment (GO:0010454)4.17165491
53response to food (GO:0032094)4.15837281
54embryonic eye morphogenesis (GO:0048048)4.14123192
55positive regulation of interleukin-8 secretion (GO:2000484)4.10468020
56negative regulation of axon extension involved in axon guidance (GO:0048843)4.09711517
57intracellular estrogen receptor signaling pathway (GO:0030520)4.09677197
58regulation of keratinocyte differentiation (GO:0045616)4.08846810
59regulation of ruffle assembly (GO:1900027)4.08608137
60outflow tract septum morphogenesis (GO:0003148)4.08092046
61epithelial cell differentiation involved in prostate gland development (GO:0060742)4.06039068
62face development (GO:0060324)4.04473260
63epithelial cell maturation (GO:0002070)4.02287435
64ceramide catabolic process (GO:0046514)3.99512312
65protein targeting to membrane (GO:0006612)3.98986016
66mammary gland alveolus development (GO:0060749)3.87811929
67hair cycle (GO:0042633)3.87748266
68molting cycle (GO:0042303)3.87748266
69oligosaccharide catabolic process (GO:0009313)3.87549630
70regulation of cardioblast differentiation (GO:0051890)3.86387121
71proteasome assembly (GO:0043248)3.83713955
72insulin-like growth factor receptor signaling pathway (GO:0048009)3.83215883
73regulation of fatty acid beta-oxidation (GO:0031998)3.79071696
74positive regulation of chemokine secretion (GO:0090197)3.78651527
75cell fate commitment involved in formation of primary germ layer (GO:0060795)3.70604907
76response to water (GO:0009415)3.70425989
77negative regulation of organelle assembly (GO:1902116)3.67676664
78striated muscle atrophy (GO:0014891)3.67269526
79amyloid precursor protein catabolic process (GO:0042987)3.64265490
80nitric oxide biosynthetic process (GO:0006809)3.63704625
81cellular response to estrogen stimulus (GO:0071391)3.61283850
82negative regulation of T cell mediated immunity (GO:0002710)3.59760545
83regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.59423910
84nuclear-transcribed mRNA catabolic process (GO:0000956)3.56079291
85prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.55449308
86negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.52808311
87epidermal cell differentiation (GO:0009913)3.48655765
88regulation of centriole replication (GO:0046599)3.45638551
89phosphate ion homeostasis (GO:0055062)3.45478395
90trivalent inorganic anion homeostasis (GO:0072506)3.45478395
91prostaglandin metabolic process (GO:0006693)3.43948173
92prostanoid metabolic process (GO:0006692)3.43948173
93prostate gland growth (GO:0060736)3.42243510
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.40580807
95regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.40232221
96mRNA catabolic process (GO:0006402)3.40002521
97peptidyl-arginine omega-N-methylation (GO:0035247)3.37183386
98epidermis development (GO:0008544)3.36385115
99hepatocyte apoptotic process (GO:0097284)3.35291716
100translation (GO:0006412)3.34813287
101negative regulation of Ras GTPase activity (GO:0034261)3.31438130
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.28594719
103branching involved in salivary gland morphogenesis (GO:0060445)3.28301815
104negative regulation of axon guidance (GO:1902668)3.27271124
105phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.25728499
106* ear development (GO:0043583)3.24744124
107mammary gland epithelial cell proliferation (GO:0033598)3.24371276
108positive regulation of T cell chemotaxis (GO:0010820)3.23451297
109regulation of T cell chemotaxis (GO:0010819)3.23451297
110regulation of hypersensitivity (GO:0002883)3.21705431
111negative regulation of epidermis development (GO:0045683)3.21636134
112phosphatidylserine acyl-chain remodeling (GO:0036150)3.21405825
113negative regulation of keratinocyte proliferation (GO:0010839)3.20765619
114regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20671331
115regulation of phospholipase A2 activity (GO:0032429)3.20147205
116biotin metabolic process (GO:0006768)3.19609636
117ribonucleoprotein complex biogenesis (GO:0022613)3.19051404
118epithelial cell-cell adhesion (GO:0090136)3.18327554
119eyelid development in camera-type eye (GO:0061029)3.17265156
120positive regulation of fatty acid beta-oxidation (GO:0032000)3.16743744
121bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16251198
122skeletal muscle adaptation (GO:0043501)3.15454383
123calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.13525613
124columnar/cuboidal epithelial cell development (GO:0002066)3.13115339
125dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09974920
126cell proliferation involved in metanephros development (GO:0072203)3.09164966
127muscle atrophy (GO:0014889)3.08927244
128* regulation of cell proliferation involved in kidney development (GO:1901722)3.08028033
129regulation of Cdc42 GTPase activity (GO:0043088)3.07046126
130semaphorin-plexin signaling pathway (GO:0071526)3.06734040
131positive regulation of gastrulation (GO:2000543)3.06619716
132proline biosynthetic process (GO:0006561)3.03710855
133positive regulation of nitric-oxide synthase activity (GO:0051000)3.03531351
134negative regulation of stress fiber assembly (GO:0051497)3.02234435
135phosphatidylinositol acyl-chain remodeling (GO:0036149)3.01052215
136embryonic skeletal joint morphogenesis (GO:0060272)3.01014581
137regulation of defense response to virus by virus (GO:0050690)2.97695124
138RNA catabolic process (GO:0006401)2.97231386
139positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.97116085
140intermediate filament organization (GO:0045109)2.96579443
141glandular epithelial cell differentiation (GO:0002067)2.95446876
142endothelial cell chemotaxis (GO:0035767)2.94616404
143regulation of chromatin binding (GO:0035561)2.94616395
144negative regulation of epidermal cell differentiation (GO:0045605)2.90616622
145sphingolipid catabolic process (GO:0030149)2.88960909
146regulation of interleukin-8 secretion (GO:2000482)2.88551300
147trophectodermal cell differentiation (GO:0001829)2.88382855
148gland morphogenesis (GO:0022612)2.87156989
149adherens junction assembly (GO:0034333)2.87139479
150positive regulation of epidermal cell differentiation (GO:0045606)2.86461957
151regulation of autophagic vacuole assembly (GO:2000785)2.85446517
152establishment of protein localization to membrane (GO:0090150)2.83483646
153positive regulation of blood vessel endothelial cell migration (GO:0043536)2.83358448
154lateral sprouting from an epithelium (GO:0060601)2.82444407
155amyloid precursor protein metabolic process (GO:0042982)2.81524176
156* interferon-gamma secretion (GO:0072643)2.79955283
157G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78420496
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.76246550
159focal adhesion assembly (GO:0048041)2.73145220
160cell-substrate adherens junction assembly (GO:0007045)2.73145220
161cellular response to estradiol stimulus (GO:0071392)2.72279514
162regulation of collateral sprouting (GO:0048670)2.71661609
163peptidyl-arginine methylation (GO:0018216)2.70470475
164peptidyl-arginine N-methylation (GO:0035246)2.70470475
165regulation of endothelial cell chemotaxis (GO:2001026)2.69872994
166regulation of apoptotic process involved in morphogenesis (GO:1902337)2.69690864
167* negative regulation of interleukin-2 production (GO:0032703)2.69322341
168icosanoid biosynthetic process (GO:0046456)2.69319235
169fatty acid derivative biosynthetic process (GO:1901570)2.69319235
170regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.69036476
171positive regulation of epidermis development (GO:0045684)2.69032354
172spinal cord association neuron differentiation (GO:0021527)2.67784864
173oocyte development (GO:0048599)2.67447729
174post-embryonic morphogenesis (GO:0009886)2.66553641
175regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.66341259
176negative regulation of DNA-templated transcription, elongation (GO:0032785)2.64956280
177response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.64498386
178atrioventricular valve morphogenesis (GO:0003181)2.63316040
179positive regulation of cell fate commitment (GO:0010455)2.63306869
180* regulation of establishment or maintenance of cell polarity (GO:0032878)2.62746806
181positive regulation of keratinocyte differentiation (GO:0045618)2.60517660
182ectoderm development (GO:0007398)2.58203833
183regulation of polysaccharide biosynthetic process (GO:0032885)2.56457045
184desmosome organization (GO:0002934)10.2187057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.19106986
2ESR1_20079471_ChIP-ChIP_T-47D_Human5.86455528
3ESR1_15608294_ChIP-ChIP_MCF-7_Human3.88707939
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.51443794
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.37917364
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28545803
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.22274860
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human3.05163288
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.95826679
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.88080498
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.88080498
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.88080498
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.64124090
14P63_26484246_Chip-Seq_KERATINOCYTES_Human2.60191546
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.41716547
16ZNF263_19887448_ChIP-Seq_K562_Human2.40778848
17SOX9_24532713_ChIP-Seq_HFSC_Mouse2.15146210
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.11519131
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10930880
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09436347
21MYC_22102868_ChIP-Seq_BL_Human2.03059289
22* TP63_17297297_ChIP-ChIP_HaCaT_Human14.0007478
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99637757
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.96639128
25TCF7_22412390_ChIP-Seq_EML_Mouse1.87241729
26PKCTHETA_26484144_Chip-Seq_BREAST_Human1.82793273
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77758164
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76433637
29* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76422578
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76422578
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72109168
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71941940
33LXR_22292898_ChIP-Seq_THP-1_Human1.69603960
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66588144
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65638967
36VDR_21846776_ChIP-Seq_THP-1_Human1.65151326
37* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63516245
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61081660
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60834834
40* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60221919
41* KDM5A_27292631_Chip-Seq_BREAST_Human1.59848859
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59377143
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.54223900
44ELF5_23300383_ChIP-Seq_T47D_Human1.54095850
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53442262
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.53273379
47* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49944621
48* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.49904311
49* KDM2B_26808549_Chip-Seq_DND41_Human1.48996925
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.45136043
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.43568897
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43433337
53* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43429791
54IRF1_19129219_ChIP-ChIP_H3396_Human1.40227629
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39432710
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38683318
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.38533085
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.38112603
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36722767
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36649077
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.36396600
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.36135081
63CREB1_26743006_Chip-Seq_LNCaP_Human1.35358403
64VDR_22108803_ChIP-Seq_LS180_Human1.33235532
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31900520
66SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.31350920
67P68_20966046_ChIP-Seq_HELA_Human1.30476477
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.27361219
69* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25221969
70SMC4_20622854_ChIP-Seq_HELA_Human1.24913644
71KLF5_25053715_ChIP-Seq_YYC3_Human1.23826732
72* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21881111
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21867545
74* TP53_20018659_ChIP-ChIP_R1E_Mouse1.19711941
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18242572
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17369912
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16861770
78KDM2B_26808549_Chip-Seq_K562_Human1.15672301
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14285166
80CHD1_26751641_Chip-Seq_LNCaP_Human1.12380571
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11121490
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11079198
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10714769
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10669515
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10347923
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09952111
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09717213
88* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08151431
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06780032
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06446238
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.06160935
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06053613
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05884210
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.03866736
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03620354
96* SOX2_20726797_ChIP-Seq_SW620_Human1.03543830
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03299604
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.01313461
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00479086
100* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00053517
101TTF2_22483619_ChIP-Seq_HELA_Human0.99507622
102GATA4_25053715_ChIP-Seq_YYC3_Human0.98982949
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98697319
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98388465
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97166448
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96826935
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96778605
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96739636
109* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96326323
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.94365125
111* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.93787607
112* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93363009
113FOXM1_23109430_ChIP-Seq_U2OS_Human0.93298860
114* MAF_26560356_Chip-Seq_TH1_Human0.92626328
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92354960
116MAF_26560356_Chip-Seq_TH2_Human0.92247329
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92128282
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92004101
119TP63_22573176_ChIP-Seq_HFKS_Human0.91920425
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91858115
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91761619
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89958099
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89617217
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89388927
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89103937
126* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88633174
127BP1_19119308_ChIP-ChIP_Hs578T_Human0.88307442
128AHR_22903824_ChIP-Seq_MCF-7_Human0.87803404
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86978860
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.86967056
131RACK7_27058665_Chip-Seq_MCF-7_Human0.86928214
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86867891
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86784493
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86451761
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86265648
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85616463
137ATF3_27146783_Chip-Seq_COLON_Human0.85542233
138JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85273614
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84567762
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84170146
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.83512240
142GATA6_21074721_ChIP-Seq_CACO-2_Human0.83443799
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.82408554
144* RNF2_27304074_Chip-Seq_NSC_Mouse0.80221575
145GABP_17652178_ChIP-ChIP_JURKAT_Human0.80057337
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.79920671
147TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.78804856
148* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76049496
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75344982
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72921291
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72705104
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72311759
153GATA6_25053715_ChIP-Seq_YYC3_Human0.72300877
154SA1_27219007_Chip-Seq_Bcells_Human0.71309920
155RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68805611
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.68673560
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.66342826
158FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66342826
159CEBPB_22108803_ChIP-Seq_LS180_Human0.66317203
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.66045395
161* CBX2_27304074_Chip-Seq_ESCs_Mouse0.65266797
162UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.64564220
163* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.64211996
164* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63827556
165XRN2_22483619_ChIP-Seq_HELA_Human0.61282768
166HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.59368322
167TP63_23658742_ChIP-Seq_EP156T_Human0.58457433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier5.58491259
2MP0003941_abnormal_skin_development4.72398664
3* MP0004381_abnormal_hair_follicle4.54093755
4MP0010234_abnormal_vibrissa_follicle4.06548765
5MP0009780_abnormal_chondrocyte_physiolo3.63239180
6MP0002254_reproductive_system_inflammat3.61921069
7MP0003705_abnormal_hypodermis_morpholog3.30129014
8* MP0005501_abnormal_skin_physiology3.24864616
9* MP0000383_abnormal_hair_follicle3.23988342
10MP0000566_synostosis3.14112284
11* MP0001216_abnormal_epidermal_layer3.13957861
12MP0009379_abnormal_foot_pigmentation3.10667359
13MP0005076_abnormal_cell_differentiation3.06451112
14MP0002009_preneoplasia3.05399797
15* MP0002098_abnormal_vibrissa_morphology2.69387829
16* MP0010678_abnormal_skin_adnexa2.59878488
17MP0003136_yellow_coat_color2.43231099
18MP0003453_abnormal_keratinocyte_physiol2.42482808
19MP0003315_abnormal_perineum_morphology2.31841021
20MP0005083_abnormal_biliary_tract2.28776615
21* MP0000377_abnormal_hair_follicle2.25784116
22* MP0000647_abnormal_sebaceous_gland2.25553178
23* MP0002060_abnormal_skin_morphology2.23465193
24MP0010352_gastrointestinal_tract_polyps2.22823139
25MP0005275_abnormal_skin_tensile2.21247274
26* MP0010771_integument_phenotype2.16501504
27MP0009384_cardiac_valve_regurgitation2.07838566
28MP0004947_skin_inflammation2.06149642
29MP0001346_abnormal_lacrimal_gland1.97872372
30MP0003693_abnormal_embryo_hatching1.97773642
31MP0000462_abnormal_digestive_system1.96563155
32MP0004233_abnormal_muscle_weight1.96387061
33MP0000762_abnormal_tongue_morphology1.93828744
34MP0000678_abnormal_parathyroid_gland1.92069704
35MP0003123_paternal_imprinting1.89353435
36MP0003191_abnormal_cellular_cholesterol1.86194095
37MP0003763_abnormal_thymus_physiology1.85487873
38MP0000579_abnormal_nail_morphology1.78439090
39MP0005646_abnormal_pituitary_gland1.77800952
40MP0009672_abnormal_birth_weight1.77215030
41MP0001849_ear_inflammation1.76987475
42MP0003011_delayed_dark_adaptation1.66367399
43MP0003566_abnormal_cell_adhesion1.66269131
44MP0005248_abnormal_Harderian_gland1.65208439
45MP0001348_abnormal_lacrimal_gland1.64184178
46MP0000467_abnormal_esophagus_morphology1.63418744
47MP0002277_abnormal_respiratory_mucosa1.46138725
48MP0008995_early_reproductive_senescence1.45887370
49MP0003638_abnormal_response/metabolism_1.43115127
50* MP0009931_abnormal_skin_appearance1.40841098
51MP0002909_abnormal_adrenal_gland1.38810311
52MP0004957_abnormal_blastocyst_morpholog1.37553779
53MP0002132_abnormal_respiratory_system1.37149144
54MP0005408_hypopigmentation1.36140966
55MP0000470_abnormal_stomach_morphology1.35984561
56MP0002736_abnormal_nociception_after1.35432309
57MP0002006_tumorigenesis1.29350123
58MP0005023_abnormal_wound_healing1.25763672
59* MP0000367_abnormal_coat/_hair1.25610605
60MP0005058_abnormal_lysosome_morphology1.25137779
61MP0002166_altered_tumor_susceptibility1.24931941
62MP0001851_eye_inflammation1.23912801
63MP0000538_abnormal_urinary_bladder1.23583271
64MP0001853_heart_inflammation1.23542376
65MP0003183_abnormal_peptide_metabolism1.21664772
66MP0008260_abnormal_autophagy1.21213193
67MP0004264_abnormal_extraembryonic_tissu1.21112242
68* MP0001191_abnormal_skin_condition1.20469987
69* MP0000627_abnormal_mammary_gland1.18778778
70MP0001919_abnormal_reproductive_system1.18715935
71MP0010030_abnormal_orbit_morphology1.13725603
72MP0004782_abnormal_surfactant_physiolog1.11084869
73MP0008872_abnormal_physiological_respon1.09598736
74MP0005409_darkened_coat_color1.09589807
75MP0000534_abnormal_ureter_morphology1.09245766
76MP0000490_abnormal_crypts_of1.09020731
77MP0000537_abnormal_urethra_morphology1.08233556
78MP0005671_abnormal_response_to1.06693297
79MP0000465_gastrointestinal_hemorrhage1.05695125
80MP0004019_abnormal_vitamin_homeostasis0.97109917
81MP0003866_abnormal_defecation0.97074842
82MP0001968_abnormal_touch/_nociception0.95434741
83MP0002089_abnormal_postnatal_growth/wei0.95261270
84MP0000372_irregular_coat_pigmentation0.93589301
85MP0003718_maternal_effect0.92511502
86MP0003878_abnormal_ear_physiology0.90577334
87MP0005377_hearing/vestibular/ear_phenot0.90577334
88MP0001765_abnormal_ion_homeostasis0.88505567
89MP0001664_abnormal_digestion0.87662332
90* MP0001340_abnormal_eyelid_morphology0.86973664
91MP0003786_premature_aging0.86638534
92MP0009703_decreased_birth_body0.86252684
93MP0002160_abnormal_reproductive_system0.85629224
94MP0003787_abnormal_imprinting0.85097047
95MP0005666_abnormal_adipose_tissue0.85057707
96MP0001666_abnormal_nutrient_absorption0.82073344
97MP0001727_abnormal_embryo_implantation0.81926979
98MP0003567_abnormal_fetal_cardiomyocyte0.81792481
99MP0009333_abnormal_splenocyte_physiolog0.81599945
100MP0002148_abnormal_hypersensitivity_rea0.81577901
101MP0004185_abnormal_adipocyte_glucose0.81207319
102MP0002877_abnormal_melanocyte_morpholog0.79231313
103* MP0003942_abnormal_urinary_system0.78669651
104MP0003828_pulmonary_edema0.77205901
105MP0005451_abnormal_body_composition0.76925482
106MP0002127_abnormal_cardiovascular_syste0.76584345
107MP0000371_diluted_coat_color0.76358521
108MP0000613_abnormal_salivary_gland0.75645037
109MP0009840_abnormal_foam_cell0.75461864
110* MP0000427_abnormal_hair_cycle0.72596121
111MP0005375_adipose_tissue_phenotype0.72028836
112MP0000003_abnormal_adipose_tissue0.71668398
113MP0002108_abnormal_muscle_morphology0.71130042
114* MP0003938_abnormal_ear_development0.70346310
115MP0001881_abnormal_mammary_gland0.69929516
116MP0003937_abnormal_limbs/digits/tail_de0.68306075
117MP0001873_stomach_inflammation0.67487563
118MP0002086_abnormal_extraembryonic_tissu0.67388383
119MP0000477_abnormal_intestine_morphology0.67371070
120MP0002111_abnormal_tail_morphology0.66672882
121* MP0001243_abnormal_dermal_layer0.66442833
122MP0001186_pigmentation_phenotype0.65164344
123MP0002102_abnormal_ear_morphology0.64326188
124MP0003436_decreased_susceptibility_to0.64118496
125MP0009115_abnormal_fat_cell0.63990302
126MP0000681_abnormal_thyroid_gland0.63413184
127MP0003984_embryonic_growth_retardation0.62210412
128MP0005508_abnormal_skeleton_morphology0.62156028
129MP0010155_abnormal_intestine_physiology0.61710237
130MP0002092_abnormal_eye_morphology0.61491123
131MP0001697_abnormal_embryo_size0.60753401
132* MP0005075_abnormal_melanosome_morpholog0.59843202
133MP0005000_abnormal_immune_tolerance0.59269727
134MP0003115_abnormal_respiratory_system0.59207862
135MP0002075_abnormal_coat/hair_pigmentati0.59132311
136MP0005389_reproductive_system_phenotype0.58721773
137* MP0002088_abnormal_embryonic_growth/wei0.58653078
138MP0002249_abnormal_larynx_morphology0.57842355
139MP0002332_abnormal_exercise_endurance0.57483104
140MP0001542_abnormal_bone_strength0.57020160
141MP0005165_increased_susceptibility_to0.54710973
142MP0002095_abnormal_skin_pigmentation0.54217582
143* MP0003936_abnormal_reproductive_system0.54018898
144* MP0001800_abnormal_humoral_immune0.53950208
145MP0003879_abnormal_hair_cell0.53517881
146MP0003724_increased_susceptibility_to0.52839261
147MP0002163_abnormal_gland_morphology0.52735396
148* MP0000703_abnormal_thymus_morphology0.52433563
149MP0005174_abnormal_tail_pigmentation0.50918523
150MP0000858_altered_metastatic_potential0.50382008
151MP0008770_decreased_survivor_rate0.50284799
152MP0003755_abnormal_palate_morphology0.49812637
153MP0005367_renal/urinary_system_phenotyp0.48977329
154MP0000516_abnormal_urinary_system0.48977329

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)7.94338206
2Asymmetry of the thorax (HP:0001555)5.84025365
3Parakeratosis (HP:0001036)5.58117536
4Hypotrichosis (HP:0001006)5.57447203
5Lip pit (HP:0100267)5.36587029
6Abnormality of cells of the erythroid lineage (HP:0012130)5.11464049
7Abnormality of secondary sexual hair (HP:0009888)4.96897853
8Abnormality of the axillary hair (HP:0100134)4.96897853
9Sparse lateral eyebrow (HP:0005338)4.92379065
10Fragile nails (HP:0001808)4.70455197
11Reticulocytopenia (HP:0001896)4.68937973
12Deformed sella turcica (HP:0002681)4.54071238
13Abnormal number of erythroid precursors (HP:0012131)4.44005881
14Concave nail (HP:0001598)4.39478680
15Woolly hair (HP:0002224)4.38969291
16Micronodular cirrhosis (HP:0001413)4.31852422
17Congenital ichthyosiform erythroderma (HP:0007431)4.30029809
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.02059877
19Absent frontal sinuses (HP:0002688)3.83833678
20Macrocytic anemia (HP:0001972)3.76972725
21Microglossia (HP:0000171)3.71234825
22Thin bony cortex (HP:0002753)3.65896400
23Sparse eyelashes (HP:0000653)3.60699117
24Plantar hyperkeratosis (HP:0007556)3.58588493
25Abnormality of liposaccharide metabolism (HP:0010968)3.54379680
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.54379680
27Abnormality of glycolipid metabolism (HP:0010969)3.54379680
28Pallor (HP:0000980)3.51291721
29Onycholysis (HP:0001806)3.49430717
30Breast carcinoma (HP:0003002)3.48830918
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.41351088
32Abnormality of the frontal sinuses (HP:0002687)3.39666819
33Amelogenesis imperfecta (HP:0000705)3.37247054
34Hyperacusis (HP:0010780)3.37074800
35Erythema (HP:0010783)3.35097832
36Macroorchidism (HP:0000053)3.33486844
37Germ cell neoplasia (HP:0100728)3.32350766
38Enlarged penis (HP:0000040)3.29953862
39Pili torti (HP:0003777)3.23174925
40Long toe (HP:0010511)3.18467680
41Testicular neoplasm (HP:0010788)3.15038480
42Milia (HP:0001056)3.14878507
43Aplasia cutis congenita (HP:0001057)3.12192386
44Nasolacrimal duct obstruction (HP:0000579)3.09837122
45Abnormal hemoglobin (HP:0011902)3.08736790
46Lymphangioma (HP:0100764)3.08130805
47Conical tooth (HP:0000698)3.00716339
48Abnormality of the sella turcica (HP:0002679)2.97473306
49Popliteal pterygium (HP:0009756)2.96644551
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.96321144
51Hyperparathyroidism (HP:0000843)2.95375040
52Esophageal varix (HP:0002040)2.93376849
53Congenital, generalized hypertrichosis (HP:0004540)2.92185599
54Abnormality of nail color (HP:0100643)2.90401458
55Erythroderma (HP:0001019)2.87315381
56Broad face (HP:0000283)2.87069523
57Testicular atrophy (HP:0000029)2.83456214
58Abdominal distention (HP:0003270)2.79233542
59Flat acetabular roof (HP:0003180)2.78494811
60Palmoplantar hyperkeratosis (HP:0000972)2.76995599
61Partial duplication of thumb phalanx (HP:0009944)2.73221578
62Abnormal blistering of the skin (HP:0008066)2.73219742
63Nail dystrophy (HP:0008404)2.72921813
64Sparse scalp hair (HP:0002209)2.72894264
65Anhidrosis (HP:0000970)2.69747481
66Right ventricular cardiomyopathy (HP:0011663)2.68618184
67Palmar hyperkeratosis (HP:0010765)2.65931092
68Hypohidrosis (HP:0000966)2.60983630
69Abnormality of the lacrimal duct (HP:0011481)2.56768198
70Stenosis of the external auditory canal (HP:0000402)2.56060169
71Hyporeflexia of lower limbs (HP:0002600)2.54273819
72Syringomyelia (HP:0003396)2.52659685
73Spinal cord lesions (HP:0100561)2.52659685
74Ulnar claw (HP:0001178)2.52628854
75Increased IgE level (HP:0003212)2.50191042
76Exostoses (HP:0100777)2.46949852
77Buphthalmos (HP:0000557)2.46190760
78Corneal erosion (HP:0200020)2.45351980
79Natal tooth (HP:0000695)2.44192644
80Hypercortisolism (HP:0001578)2.43865569
81Abnormality of the salivary glands (HP:0010286)2.42973735
82Distal lower limb muscle weakness (HP:0009053)2.41781844
83Gangrene (HP:0100758)2.37901800
84Curly hair (HP:0002212)2.32744541
85Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.32667334
86Congenital glaucoma (HP:0001087)2.32391300
87Partial duplication of the phalanx of hand (HP:0009999)2.30190511
88Blepharitis (HP:0000498)2.27489772
89Microretrognathia (HP:0000308)2.27366389
90Deep philtrum (HP:0002002)2.25458580
91Cheilitis (HP:0100825)2.25183459
92Abnormality of the umbilical cord (HP:0010881)2.25151328
93High pitched voice (HP:0001620)2.24638386
94Abnormality of calcium-phosphate metabolism (HP:0100530)2.21982811
95Abnormality of the gastric mucosa (HP:0004295)2.16054969
96Abnormality of the nasolacrimal system (HP:0000614)2.13947482
97Patellar dislocation (HP:0002999)2.12066045
98Cervical subluxation (HP:0003308)2.10617405
99Growth hormone excess (HP:0000845)2.10554486
100Ectropion (HP:0000656)2.10539930
101Severe Myopia (HP:0011003)2.09862695
102Oligodontia (HP:0000677)2.09474867
103Orchitis (HP:0100796)2.07816927
104Paralysis (HP:0003470)2.06575115
105Alopecia of scalp (HP:0002293)2.02281596
106Spinal cord compression (HP:0002176)2.01943679
107Aplasia/hypoplasia of the uterus (HP:0008684)2.01650445
108Aplasia involving bones of the upper limbs (HP:0009823)2.01589825
109Aplasia of the phalanges of the hand (HP:0009802)2.01589825
110Aplasia involving bones of the extremities (HP:0009825)2.01589825
111Abnormality of the parietal bone (HP:0002696)2.00974963
112Pterygium (HP:0001059)2.00758562
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98004195
114Conjunctival hamartoma (HP:0100780)1.97622682
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.97372602
116Thick nail (HP:0001805)1.96938404
117Abnormal hair laboratory examination (HP:0003328)1.96544186
118Trismus (HP:0000211)1.95662005
119Bicornuate uterus (HP:0000813)1.95286781
120Ventricular tachycardia (HP:0004756)1.93520219
121Acanthosis nigricans (HP:0000956)1.93466830
122Retrobulbar optic neuritis (HP:0100654)1.92061246
123Optic neuritis (HP:0100653)1.92061246
124Hyperphosphatemia (HP:0002905)1.91579863
125Poor head control (HP:0002421)1.90713920
126Advanced eruption of teeth (HP:0006288)1.90277119
127Heterochromia iridis (HP:0001100)1.88734382
128Hamartoma of the eye (HP:0010568)1.88046343
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87703498
130EMG: neuropathic changes (HP:0003445)1.85723558
131Down-sloping shoulders (HP:0200021)1.85229362
132Bilateral microphthalmos (HP:0007633)1.82043310
133Abnormal umbilical cord blood vessels (HP:0011403)1.81378917
134Single umbilical artery (HP:0001195)1.81378917
135Abnormality of the fetal cardiovascular system (HP:0010948)1.81378917
136Hypopigmentation of the fundus (HP:0007894)1.80840434
137Absent eyebrow (HP:0002223)1.79862657
138Pruritus (HP:0000989)1.79738871
139Morphological abnormality of the middle ear (HP:0008609)1.78584377
140Premature ovarian failure (HP:0008209)1.78544193
141Aplasia of the musculature (HP:0100854)1.78207397
142Short clavicles (HP:0000894)1.78193940
143Stridor (HP:0010307)1.77971432
144Fasciculations (HP:0002380)1.77193604
145Abnormally folded helix (HP:0008544)1.76812823
1463-Methylglutaconic aciduria (HP:0003535)1.76565702
147Hypoalbuminemia (HP:0003073)1.76552029
148Abnormal albumin level (HP:0012116)1.76552029
149Seborrheic dermatitis (HP:0001051)1.75483537
150Renal agenesis (HP:0000104)1.75476411
151Flat capital femoral epiphysis (HP:0003370)1.75460544
152Myositis (HP:0100614)1.74925115
153Reticulocytosis (HP:0001923)1.74478746
154Apathy (HP:0000741)1.74312566
155Ridged nail (HP:0001807)1.73599801
156Brittle hair (HP:0002299)1.73104248
157Hypoplastic labia majora (HP:0000059)1.72894618
158Visceral angiomatosis (HP:0100761)1.72484005
159Diaphragmatic weakness (HP:0009113)1.71789536
160Cardiomegaly (HP:0001640)1.71786188
161Atrophic scars (HP:0001075)1.71741873
162Meningioma (HP:0002858)1.71557123
163Fused cervical vertebrae (HP:0002949)1.71539917
164Elfin facies (HP:0004428)1.71377794
165Chromsome breakage (HP:0040012)1.71083517
166White forelock (HP:0002211)1.71063159
167Overriding aorta (HP:0002623)1.70814438
168Long palpebral fissure (HP:0000637)1.70299232
169Diminished motivation (HP:0000745)1.69195966
170Depressed nasal ridge (HP:0000457)1.68154622
171Easy fatigability (HP:0003388)1.68012067
172Abnormality of the distal phalanges of the toes (HP:0010182)1.66841636
173Patchy hypopigmentation of hair (HP:0011365)1.66008174
174Myopathic facies (HP:0002058)1.65647933
175Triphalangeal thumb (HP:0001199)1.65416972
176Tracheal stenosis (HP:0002777)1.63903687
177Neoplasm of the thyroid gland (HP:0100031)1.63512264
178Thyroid carcinoma (HP:0002890)1.63385653
179* Hypoparathyroidism (HP:0000829)1.62280833
180Unilateral renal agenesis (HP:0000122)1.62053640
181Mucopolysacchariduria (HP:0008155)1.61479502
182Urinary glycosaminoglycan excretion (HP:0003541)1.61479502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.48065589
2PKN24.49415035
3SIK14.16330431
4RPS6KB23.51385583
5MST43.41544463
6SCYL23.23812192
7MST1R3.22081837
8TXK3.01467213
9PIK3CA2.47919845
10MAPKAPK32.43456580
11MAP3K32.40234318
12TESK12.39766840
13SMG12.23718392
14TESK22.13569354
15SIK32.13478419
16WEE12.10084832
17EPHA210.0978044
18NEK61.96469666
19GRK71.90633906
20STK241.87328563
21BUB11.86480978
22STK101.85846240
23NME21.83336165
24GRK11.65975091
25STK161.62789149
26PTK61.48317959
27PIM21.41276953
28FER1.39960208
29GRK51.39712090
30PAK41.32765798
31TGFBR21.32024146
32RPS6KA21.30392984
33VRK21.27535011
34LRRK21.26276880
35IRAK31.24683537
36AKT31.21700593
37SRPK11.21111914
38MAP2K21.14776705
39EIF2AK21.13065295
40GRK61.10971381
41DYRK31.09628860
42TRPM71.09387188
43EIF2AK11.08611400
44MAPKAPK51.02552150
45RET0.97224572
46RIPK10.94880878
47IKBKB0.93399904
48MTOR0.92503411
49MAP3K120.91459927
50MUSK0.89276119
51ICK0.88365386
52EPHB20.86745361
53CDK30.85832945
54ADRBK20.83823528
55NME10.82981032
56RPS6KC10.80960678
57RPS6KL10.80960678
58NTRK20.78882351
59FGFR30.78786308
60TYK20.78006715
61TRIM280.77350555
62EEF2K0.75534204
63EPHA30.75156791
64RPS6KB10.71952043
65PRKCI0.71355731
66MAP2K60.69996327
67RPS6KA60.69821258
68BLK0.69749054
69ITK0.68340588
70TBK10.67711773
71BMPR1B0.67642827
72KDR0.67524545
73PLK40.66661807
74ERN10.66007331
75MATK0.64532423
76CAMKK10.64446951
77DYRK20.63876283
78MAP4K10.63853145
79NLK0.61671513
80TLK10.61668730
81FGFR40.60701629
82TTK0.59868035
83MAP3K20.59507624
84PDPK10.59099969
85PRKD10.58875619
86MAPKAPK20.58560351
87DMPK0.57257849
88MET0.56818571
89CASK0.56773824
90ADRBK10.56100318
91MOS0.55455627
92MAPK120.54916234
93LIMK10.54877495
94FGFR20.54463438
95CAMK2B0.51741700
96MAPK40.49552955
97TAF10.48742318
98TGFBR10.48344945
99CAMK2G0.48270820
100MARK10.47894590
101TAOK30.47762987
102ERBB30.47147571
103RPS6KA50.47131182
104MAPK70.46868954
105IKBKE0.45842143
106AURKB0.43058376
107HCK0.42943427
108CHUK0.42308769
109RPS6KA10.41328547
110ILK0.41057447
111MAP3K100.40682600
112TAOK10.40512370
113CAMK2D0.39827775
114TYRO30.39528690
115LCK0.39088622
116PRKD20.37814575
117TNK20.37768503
118CAMK10.37251702
119SYK0.37054714
120YES10.36979176
121PDK10.36899082
122PIK3CG0.36414445
123DAPK10.36363519
124CDK120.35906430
125ZAP700.34859006
126PRKCE0.34237524
127RPS6KA40.34057734
128MAP3K90.33333827
129AKT20.32601131
130MAPK80.32233686
131JAK30.31841049
132CDK70.30990512
133AURKA0.30929210
134MAP2K10.30874755
135PTK20.30668256
136BRSK20.29859471
137DDR20.29662641
138PRKCD0.29552616
139MAP3K140.28586107
140BMPR20.27769495
141IRAK40.27299323
142MELK0.25768507
143MYLK0.25619253
144PDGFRA0.24571564
145MAPK30.24100144
146PBK0.21063054
147CSF1R0.20731971
148EPHB10.20004024
149FGFR10.19675051
150PRKCZ0.18707484
151VRK10.18486153
152WNK40.18473801
153CDK60.18021363
154ROCK20.17814308
155CSNK2A10.17674669
156HIPK20.17658279
157CDK80.17392048
158MAPK90.16560009
159CSNK1D0.14909172

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.00096859
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.69259905
3Proteasome_Homo sapiens_hsa030503.16275906
4Arachidonic acid metabolism_Homo sapiens_hsa005902.81376769
5Sphingolipid metabolism_Homo sapiens_hsa006002.67100440
6Endometrial cancer_Homo sapiens_hsa052132.66410647
7Non-small cell lung cancer_Homo sapiens_hsa052232.28598954
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22884701
9Thyroid hormone signaling pathway_Homo sapiens_hsa049192.12989733
10Longevity regulating pathway - mammal_Homo sapiens_hsa042112.12135912
11mTOR signaling pathway_Homo sapiens_hsa041502.09001616
12Linoleic acid metabolism_Homo sapiens_hsa005912.08017953
13Autoimmune thyroid disease_Homo sapiens_hsa053202.04875540
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.03655973
15Chronic myeloid leukemia_Homo sapiens_hsa052201.96422025
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.95851711
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94596129
18Asthma_Homo sapiens_hsa053101.89201676
19Renal cell carcinoma_Homo sapiens_hsa052111.86208240
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84149251
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83965841
22Allograft rejection_Homo sapiens_hsa053301.83534026
23Prolactin signaling pathway_Homo sapiens_hsa049171.79632675
24AMPK signaling pathway_Homo sapiens_hsa041521.79285092
25ErbB signaling pathway_Homo sapiens_hsa040121.77472160
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.75960373
27Estrogen signaling pathway_Homo sapiens_hsa049151.75325978
28* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72043432
29Basal cell carcinoma_Homo sapiens_hsa052171.69564653
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.63581558
31Insulin signaling pathway_Homo sapiens_hsa049101.62213517
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.61345806
33Primary immunodeficiency_Homo sapiens_hsa053401.59293006
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58359362
35Prostate cancer_Homo sapiens_hsa052151.58272599
36Choline metabolism in cancer_Homo sapiens_hsa052311.56084193
37RNA polymerase_Homo sapiens_hsa030201.55658917
38Hedgehog signaling pathway_Homo sapiens_hsa043401.53435799
39Vibrio cholerae infection_Homo sapiens_hsa051101.51990286
40Insulin resistance_Homo sapiens_hsa049311.45160115
41T cell receptor signaling pathway_Homo sapiens_hsa046601.44704414
42p53 signaling pathway_Homo sapiens_hsa041151.39980461
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38986851
44Glioma_Homo sapiens_hsa052141.35952639
45B cell receptor signaling pathway_Homo sapiens_hsa046621.30236846
46Pentose phosphate pathway_Homo sapiens_hsa000301.26668385
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23614740
48Pancreatic cancer_Homo sapiens_hsa052121.21833977
49Hippo signaling pathway_Homo sapiens_hsa043901.20761513
50Hematopoietic cell lineage_Homo sapiens_hsa046401.18329922
51Ether lipid metabolism_Homo sapiens_hsa005651.18130648
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.16522972
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.14474295
54Tight junction_Homo sapiens_hsa045301.14247769
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12335332
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12219284
57Hepatitis B_Homo sapiens_hsa051611.10252955
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10030672
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.09348553
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08908919
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08537052
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.07132158
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04663218
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04118165
65Histidine metabolism_Homo sapiens_hsa003401.03486447
66Fatty acid elongation_Homo sapiens_hsa000621.02783151
67Sulfur relay system_Homo sapiens_hsa041221.01510280
68Oxidative phosphorylation_Homo sapiens_hsa001900.99317711
69Melanoma_Homo sapiens_hsa052180.97043335
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95291522
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.94777425
72Graft-versus-host disease_Homo sapiens_hsa053320.85744047
73Lysosome_Homo sapiens_hsa041420.85259041
74Phenylalanine metabolism_Homo sapiens_hsa003600.84997940
75Retinol metabolism_Homo sapiens_hsa008300.82236222
76Ovarian steroidogenesis_Homo sapiens_hsa049130.81648733
77Colorectal cancer_Homo sapiens_hsa052100.80741563
78Regulation of autophagy_Homo sapiens_hsa041400.79450683
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.77764182
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77570455
81MicroRNAs in cancer_Homo sapiens_hsa052060.76155823
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75635747
83Spliceosome_Homo sapiens_hsa030400.74403076
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.70382196
85Apoptosis_Homo sapiens_hsa042100.69508223
86mRNA surveillance pathway_Homo sapiens_hsa030150.69196787
87Wnt signaling pathway_Homo sapiens_hsa043100.67437091
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67154877
89Hepatitis C_Homo sapiens_hsa051600.67131720
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66616118
91Epstein-Barr virus infection_Homo sapiens_hsa051690.64988777
92Other glycan degradation_Homo sapiens_hsa005110.63643624
93N-Glycan biosynthesis_Homo sapiens_hsa005100.63194311
94ECM-receptor interaction_Homo sapiens_hsa045120.62105857
95HTLV-I infection_Homo sapiens_hsa051660.61847629
96HIF-1 signaling pathway_Homo sapiens_hsa040660.61819549
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.61685366
98Measles_Homo sapiens_hsa051620.60903974
99ABC transporters_Homo sapiens_hsa020100.60415452
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59719114
101Axon guidance_Homo sapiens_hsa043600.59260158
102Thyroid cancer_Homo sapiens_hsa052160.57148259
103Lysine degradation_Homo sapiens_hsa003100.55990385
104Proteoglycans in cancer_Homo sapiens_hsa052050.55913475
105Adherens junction_Homo sapiens_hsa045200.55882901
106Glucagon signaling pathway_Homo sapiens_hsa049220.55757703
107Fanconi anemia pathway_Homo sapiens_hsa034600.55101699
108Viral carcinogenesis_Homo sapiens_hsa052030.54578882
109TNF signaling pathway_Homo sapiens_hsa046680.54440410
110Melanogenesis_Homo sapiens_hsa049160.54318433
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.53391657
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53277600
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53001775
114Notch signaling pathway_Homo sapiens_hsa043300.50337834
115Pathways in cancer_Homo sapiens_hsa052000.50186632
116Parkinsons disease_Homo sapiens_hsa050120.49488156
117Endocytosis_Homo sapiens_hsa041440.48182802
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48154099
119Small cell lung cancer_Homo sapiens_hsa052220.47957218
120FoxO signaling pathway_Homo sapiens_hsa040680.45622932
121Steroid biosynthesis_Homo sapiens_hsa001000.44392063
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44031357
123Herpes simplex infection_Homo sapiens_hsa051680.43705983
124Pyrimidine metabolism_Homo sapiens_hsa002400.43515742
125Phototransduction_Homo sapiens_hsa047440.42570016
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.42540163
127Toxoplasmosis_Homo sapiens_hsa051450.42468924
128Alzheimers disease_Homo sapiens_hsa050100.41988718
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41737606
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41156495
131Base excision repair_Homo sapiens_hsa034100.40977814
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40893292
133Caffeine metabolism_Homo sapiens_hsa002320.40744263
134Serotonergic synapse_Homo sapiens_hsa047260.40629040
135Chemokine signaling pathway_Homo sapiens_hsa040620.39052975
136Bladder cancer_Homo sapiens_hsa052190.38202628
137Antigen processing and presentation_Homo sapiens_hsa046120.37267973
138Basal transcription factors_Homo sapiens_hsa030220.36784603
139Glutathione metabolism_Homo sapiens_hsa004800.36559290
140RNA transport_Homo sapiens_hsa030130.36258708
141Shigellosis_Homo sapiens_hsa051310.36081364
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35888904
143MAPK signaling pathway_Homo sapiens_hsa040100.35646522
144Protein export_Homo sapiens_hsa030600.34809770
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34283291
146Fructose and mannose metabolism_Homo sapiens_hsa000510.33787537
147Platelet activation_Homo sapiens_hsa046110.33772893
148Huntingtons disease_Homo sapiens_hsa050160.33406630
149GnRH signaling pathway_Homo sapiens_hsa049120.32952298
150Legionellosis_Homo sapiens_hsa051340.32905557
151VEGF signaling pathway_Homo sapiens_hsa043700.32848302
152Homologous recombination_Homo sapiens_hsa034400.32717726
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32712734
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32369094
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30719318
156Chemical carcinogenesis_Homo sapiens_hsa052040.28931869
157Inositol phosphate metabolism_Homo sapiens_hsa005620.27803035
158Tyrosine metabolism_Homo sapiens_hsa003500.27505874
159Ras signaling pathway_Homo sapiens_hsa040140.25678259
160Acute myeloid leukemia_Homo sapiens_hsa052210.23674558
161TGF-beta signaling pathway_Homo sapiens_hsa043500.23652954

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