GATA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)6.31494483
2negative regulation of metanephros development (GO:0072217)6.21703305
3plasma lipoprotein particle assembly (GO:0034377)6.11228125
4angiotensin maturation (GO:0002003)5.75561721
5phospholipid efflux (GO:0033700)5.60081221
6intestinal cholesterol absorption (GO:0030299)5.56798775
7protein-lipid complex assembly (GO:0065005)5.55890610
8NADH metabolic process (GO:0006734)5.39768572
9regulation of cholesterol esterification (GO:0010872)5.37360625
10SMAD protein signal transduction (GO:0060395)5.26641881
11very-low-density lipoprotein particle assembly (GO:0034379)4.89584274
12regulation of guanylate cyclase activity (GO:0031282)4.88701544
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.79070574
14negative regulation of keratinocyte proliferation (GO:0010839)4.72578970
15regulation of cardioblast differentiation (GO:0051890)4.53186518
16positive regulation of male gonad development (GO:2000020)4.52231529
17fat-soluble vitamin biosynthetic process (GO:0042362)4.46995626
18labyrinthine layer development (GO:0060711)4.41341724
19lipoprotein transport (GO:0042953)4.36910914
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.36484141
21cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.34725915
22virion attachment to host cell (GO:0019062)4.26753732
23adhesion of symbiont to host cell (GO:0044650)4.26753732
24cellular response to gonadotropin stimulus (GO:0071371)4.26673659
25epoxygenase P450 pathway (GO:0019373)4.17774829
26vitamin A metabolic process (GO:0006776)4.14254272
27short-chain fatty acid metabolic process (GO:0046459)4.14199394
28histamine secretion (GO:0001821)4.13686391
29homocysteine metabolic process (GO:0050667)4.00703373
30phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.93937072
31cardiac muscle adaptation (GO:0014887)3.91606903
32cardiac muscle hypertrophy in response to stress (GO:0014898)3.91606903
33muscle hypertrophy in response to stress (GO:0003299)3.91606903
34fructose metabolic process (GO:0006000)3.89265801
35endocardial cushion development (GO:0003197)3.87224916
36diaphragm development (GO:0060539)3.87073900
37high-density lipoprotein particle remodeling (GO:0034375)3.83225537
38atrial septum morphogenesis (GO:0060413)3.81914088
39response to hepatocyte growth factor (GO:0035728)3.81032412
40cellular response to hepatocyte growth factor stimulus (GO:0035729)3.81032412
41regulation of bile acid biosynthetic process (GO:0070857)3.80810358
42glucose 6-phosphate metabolic process (GO:0051156)3.79898543
43heart contraction (GO:0060047)3.74761874
44heart process (GO:0003015)3.74761874
45diacylglycerol metabolic process (GO:0046339)3.73905227
46embryonic foregut morphogenesis (GO:0048617)3.73012734
47adhesion of symbiont to host (GO:0044406)3.71250703
48positive regulation of cardiac muscle cell proliferation (GO:0060045)3.67522412
49glomerulus development (GO:0032835)3.67388664
50atrioventricular valve morphogenesis (GO:0003181)3.64409868
51receptor guanylyl cyclase signaling pathway (GO:0007168)3.62319709
52reverse cholesterol transport (GO:0043691)3.62078099
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.60737554
54hormone catabolic process (GO:0042447)3.60445792
55regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.60054590
56endocrine process (GO:0050886)3.60054590
57regulation of systemic arterial blood pressure by hormone (GO:0001990)3.60054590
58outflow tract septum morphogenesis (GO:0003148)3.59000418
59regulation of cytokine secretion involved in immune response (GO:0002739)3.57192890
60skeletal muscle organ development (GO:0060538)3.56301818
61positive regulation of guanylate cyclase activity (GO:0031284)3.53892346
62proline biosynthetic process (GO:0006561)3.53521257
63cardiac right ventricle morphogenesis (GO:0003215)3.51510913
64hemoglobin metabolic process (GO:0020027)3.49351646
65muscle cell fate commitment (GO:0042693)3.48161868
66negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.45804188
67renal system process involved in regulation of blood volume (GO:0001977)3.43498763
68negative regulation of kidney development (GO:0090185)3.40516816
69plasma lipoprotein particle organization (GO:0071827)3.39681639
70regulation of male gonad development (GO:2000018)3.38481094
71positive regulation of cardiac muscle tissue development (GO:0055025)3.38132958
72peptide catabolic process (GO:0043171)3.35257317
73actin-mediated cell contraction (GO:0070252)3.33385755
74respiratory tube development (GO:0030323)3.32056939
75response to parathyroid hormone (GO:0071107)3.27915116
76actin filament depolymerization (GO:0030042)3.27576774
77protein-lipid complex subunit organization (GO:0071825)3.25954902
78adenosine metabolic process (GO:0046085)3.25897556
79negative regulation of macrophage differentiation (GO:0045650)3.23861133
80vitamin transport (GO:0051180)3.23714747
81regulation of systemic arterial blood pressure (GO:0003073)3.21413294
82cardiac chamber formation (GO:0003207)3.21347650
83histamine transport (GO:0051608)3.20366311
84positive regulation of pseudopodium assembly (GO:0031274)3.20342626
85phospholipid scrambling (GO:0017121)3.19834129
86digestive system process (GO:0022600)3.19441912
87mesenchyme morphogenesis (GO:0072132)3.19109187
88mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17781031
89mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17781031
90response to UV-B (GO:0010224)3.17552342
91L-ascorbic acid metabolic process (GO:0019852)3.16651535
92signal peptide processing (GO:0006465)3.16609484
93lipoprotein metabolic process (GO:0042157)3.15969323
94response to gonadotropin (GO:0034698)3.15069855
95heart valve formation (GO:0003188)3.11738271
96lung secretory cell differentiation (GO:0061140)3.11107500
97dendritic cell chemotaxis (GO:0002407)3.11065774
98peptide hormone processing (GO:0016486)3.09668980
99phospholipid homeostasis (GO:0055091)3.09502591
100positive regulation of cardiac muscle tissue growth (GO:0055023)3.08656003
101muscle filament sliding (GO:0030049)3.08179732
102actin-myosin filament sliding (GO:0033275)3.08179732
103plasma lipoprotein particle remodeling (GO:0034369)3.07954402
104protein-lipid complex remodeling (GO:0034368)3.07954402
105macromolecular complex remodeling (GO:0034367)3.07954402
106cholesterol efflux (GO:0033344)3.07762721
107cardiac myofibril assembly (GO:0055003)3.07468845
108response to follicle-stimulating hormone (GO:0032354)3.05642249
109oligosaccharide catabolic process (GO:0009313)3.03859567
110regulation of cGMP biosynthetic process (GO:0030826)3.03461151
111regulation of cardiac muscle cell contraction (GO:0086004)3.01181177
112anatomical structure regression (GO:0060033)3.00668225
113regulation of cellular extravasation (GO:0002691)3.00557189
114mesenchymal to epithelial transition (GO:0060231)2.99659082
115cardiac muscle tissue morphogenesis (GO:0055008)2.99359210
116Golgi transport vesicle coating (GO:0048200)2.98126526
117COPI coating of Golgi vesicle (GO:0048205)2.98126526
118negative regulation of striated muscle cell apoptotic process (GO:0010664)2.97183272
119cyclooxygenase pathway (GO:0019371)2.96909678
120atrial cardiac muscle cell action potential (GO:0086014)2.94616727
121regulation of interleukin-8 secretion (GO:2000482)2.93849034
122gap junction assembly (GO:0016264)2.93768840
123very long-chain fatty acid metabolic process (GO:0000038)2.93216566
124drug metabolic process (GO:0017144)2.92398762
125superoxide anion generation (GO:0042554)2.91642516
126positive regulation of respiratory burst (GO:0060267)2.90104288
127midgut development (GO:0007494)2.89531383
128cardiac muscle hypertrophy (GO:0003300)2.89303989
129cytidine metabolic process (GO:0046087)2.89218584
130cytidine catabolic process (GO:0006216)2.89218584
131cytidine deamination (GO:0009972)2.89218584
132regulation of G0 to G1 transition (GO:0070316)2.88890146
133cell differentiation involved in metanephros development (GO:0072202)2.87202550
134regulation of vitamin metabolic process (GO:0030656)2.86210829
135regulation of transforming growth factor beta2 production (GO:0032909)2.85873109
136facial nerve structural organization (GO:0021612)2.85413084
137negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.83458227
138venous blood vessel morphogenesis (GO:0048845)2.83040747
139urea cycle (GO:0000050)2.82837060
140negative regulation of lipase activity (GO:0060192)2.82447802
141proline metabolic process (GO:0006560)2.82327530
142regulation of pseudopodium assembly (GO:0031272)2.81144711
143sarcomere organization (GO:0045214)2.79861702
144maintenance of gastrointestinal epithelium (GO:0030277)2.79093518
145actomyosin structure organization (GO:0031032)2.77391421
146positive regulation of heart growth (GO:0060421)2.76457153
147endoderm formation (GO:0001706)2.75671637
148thrombin receptor signaling pathway (GO:0070493)2.75099803
149kidney morphogenesis (GO:0060993)2.73658961
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73024568
151regulation of keratinocyte proliferation (GO:0010837)2.71982884
152muscle tissue morphogenesis (GO:0060415)2.71841540
153myofibril assembly (GO:0030239)2.71343885
154positive regulation of interleukin-8 secretion (GO:2000484)2.71229389
155lung vasculature development (GO:0060426)2.70669389
156fibril organization (GO:0097435)2.68848660
157muscle hypertrophy (GO:0014896)2.67364379
158sulfate transmembrane transport (GO:1902358)2.64961034
159membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64297669
160dendritic cell migration (GO:0036336)2.64051156
161striated muscle hypertrophy (GO:0014897)2.61832987
162sulfate transport (GO:0008272)2.61813037
163notochord development (GO:0030903)2.60672054
164endocardial cushion morphogenesis (GO:0003203)2.59838990
165purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58789316
1663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58789316
167desmosome organization (GO:0002934)2.57079893
168thyroid hormone metabolic process (GO:0042403)2.56478682
169definitive hemopoiesis (GO:0060216)2.56432132
170regulation of myoblast differentiation (GO:0045661)2.55186204
171extracellular fibril organization (GO:0043206)2.54885556
172embryonic digestive tract morphogenesis (GO:0048557)2.54736555
173negative regulation of mast cell activation (GO:0033004)2.54418245
174cardiac septum morphogenesis (GO:0060411)2.53400674
175digestion (GO:0007586)2.50566355
176ribosomal small subunit assembly (GO:0000028)2.50330174
177cell proliferation involved in kidney development (GO:0072111)2.49151793
178mesonephros development (GO:0001823)2.46822978
179regulation of cardiac muscle cell proliferation (GO:0060043)2.45173384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.49161638
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.98466239
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62292613
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.21172733
5* CDX2_20551321_ChIP-Seq_CACO-2_Human3.97820141
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.57359101
7E2F7_22180533_ChIP-Seq_HELA_Human3.23464846
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.21529541
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21244318
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.13302776
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.01963554
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.97048577
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91779571
14NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.59627904
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.47692929
16GATA1_22025678_ChIP-Seq_K562_Human2.45094548
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42986604
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.40083403
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33243004
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25916879
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22149240
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.22121455
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22051158
24GATA4_25053715_ChIP-Seq_YYC3_Human2.19116168
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16935005
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15351224
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12994138
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12166623
29CLOCK_20551151_ChIP-Seq_293T_Human2.11757139
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11223870
31SOX2_20726797_ChIP-Seq_SW620_Human2.10201398
32TRIM28_21343339_ChIP-Seq_HEK293_Human2.02863268
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.99387271
34RACK7_27058665_Chip-Seq_MCF-7_Human1.97835380
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97100217
36ZNF263_19887448_ChIP-Seq_K562_Human1.96628002
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93026022
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87600439
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85392370
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83672727
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80713580
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.77205000
43* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71417693
44* GATA1_19941826_ChIP-Seq_K562_Human1.68164756
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68116609
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66400730
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66163201
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65166395
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65047610
50LXR_22292898_ChIP-Seq_THP-1_Human1.64021857
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61245766
52EWS_26573619_Chip-Seq_HEK293_Human1.58595930
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57585896
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56753949
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56276273
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54527202
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54082730
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.53308800
59* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52497182
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.50718683
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50208089
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49560086
63* SRF_21415370_ChIP-Seq_HL-1_Mouse1.47161198
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43534790
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41887575
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41621516
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41418539
68CTCF_27219007_Chip-Seq_Bcells_Human1.39596299
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38961291
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38961291
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.36460249
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35662498
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.34060341
74* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.34037062
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33225587
76EOMES_21245162_ChIP-Seq_HESCs_Human1.32604056
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30265028
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.29833708
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27765448
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.27482445
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27444453
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.26736619
83ELK1_19687146_ChIP-ChIP_HELA_Human1.26289893
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26243346
85HNF4A_19822575_ChIP-Seq_HepG2_Human1.25647466
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24567881
87* GATA2_19941826_ChIP-Seq_K562_Human1.24142928
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.22640741
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22184997
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20699719
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20212144
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19830216
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19786594
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.19410986
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19326963
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.18446797
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18216800
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17836248
99GATA6_25053715_ChIP-Seq_YYC3_Human1.17598825
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17511098
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17108804
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17020764
103CJUN_26792858_Chip-Seq_BT549_Human1.16141176
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.15327059
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14900666
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14122347
107P53_22387025_ChIP-Seq_ESCs_Mouse1.13610500
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.12694691
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12654042
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12524676
111STAT1_17558387_ChIP-Seq_HELA_Human1.12387329
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11223879
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09697760
114IRF8_21731497_ChIP-ChIP_J774_Mouse1.08355710
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08233480
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07267910
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06516276
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06417268
119AR_21909140_ChIP-Seq_LNCAP_Human1.06090539
120* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05410632
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.05391731
122P300_19829295_ChIP-Seq_ESCs_Human1.05041844
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04754571
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03488632
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.03470066
126FUS_26573619_Chip-Seq_HEK293_Human1.03018794
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02616036
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.02599052
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01497740
130TP53_18474530_ChIP-ChIP_U2OS_Human1.00426514
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00172754
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00132263
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.99563799
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99538012
135* BCOR_27268052_Chip-Seq_Bcells_Human0.99267273
136KLF5_25053715_ChIP-Seq_YYC3_Human0.99068950
137FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98940729
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98263717
139AR_20517297_ChIP-Seq_VCAP_Human0.97569802
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96388779
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95011863
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.94901885
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.94901885
144STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94856962
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94515361
146EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94443919
147KDM2B_26808549_Chip-Seq_K562_Human0.94206482
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93495984
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92445719
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92381285
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92021733
152NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91563343
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.91056802
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90643381
155NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90185420
156FOXA1_25552417_ChIP-Seq_VCAP_Human0.89749074
157NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89481509
158SOX2_18555785_Chip-Seq_ESCs_Mouse0.89329879
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.88456544
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87805719
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.87431137
162GBX2_23144817_ChIP-Seq_PC3_Human0.87152253
163* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86915315
164BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86673725
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84278893
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83464175
167* ZFX_18555785_Chip-Seq_ESCs_Mouse0.83422266
168* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83224318
169P300_18555785_Chip-Seq_ESCs_Mouse0.82548279
170HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82028076
171* EED_16625203_ChIP-ChIP_MESCs_Mouse0.81740615
172SOX17_20123909_ChIP-Seq_XEN_Mouse0.81500127
173PU1_27457419_Chip-Seq_LIVER_Mouse0.81277202
174CDX2_22108803_ChIP-Seq_LS180_Human0.79541685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.86562411
2MP0000566_synostosis3.50327935
3MP0005360_urolithiasis3.28082563
4MP0005451_abnormal_body_composition3.17371008
5MP0009697_abnormal_copulation3.16119405
6MP0008004_abnormal_stomach_pH3.15047821
7MP0002139_abnormal_hepatobiliary_system3.12811501
8MP0005085_abnormal_gallbladder_physiolo3.07969992
9MP0001666_abnormal_nutrient_absorption3.03781322
10MP0004264_abnormal_extraembryonic_tissu3.01331146
11MP0003941_abnormal_skin_development2.99892250
12MP0003123_paternal_imprinting2.75849099
13MP0003191_abnormal_cellular_cholesterol2.69466555
14MP0008995_early_reproductive_senescence2.58488339
15MP0005365_abnormal_bile_salt2.48268010
16MP0005084_abnormal_gallbladder_morpholo2.47410244
17MP0002132_abnormal_respiratory_system2.30822960
18MP0002127_abnormal_cardiovascular_syste2.21019454
19MP0006054_spinal_hemorrhage2.20691737
20MP0000678_abnormal_parathyroid_gland2.15193574
21MP0004782_abnormal_surfactant_physiolog2.14505535
22MP0000490_abnormal_crypts_of2.04347492
23MP0003121_genomic_imprinting1.99054411
24MP0003122_maternal_imprinting1.94330141
25MP0001873_stomach_inflammation1.91959393
26MP0002254_reproductive_system_inflammat1.87944714
27MP0003828_pulmonary_edema1.87210181
28MP0002249_abnormal_larynx_morphology1.80187961
29MP0006138_congestive_heart_failure1.79851021
30MP0000462_abnormal_digestive_system1.79652655
31MP0002876_abnormal_thyroid_physiology1.79488059
32MP0010329_abnormal_lipoprotein_level1.78911428
33MP0005058_abnormal_lysosome_morphology1.77473871
34MP0001661_extended_life_span1.77126620
35MP0008007_abnormal_cellular_replicative1.76916608
36MP0004019_abnormal_vitamin_homeostasis1.74873228
37MP0001188_hyperpigmentation1.74046969
38MP0003115_abnormal_respiratory_system1.62949051
39MP0002009_preneoplasia1.61783861
40MP0009643_abnormal_urine_homeostasis1.57158261
41MP0001664_abnormal_digestion1.56296026
42MP0002148_abnormal_hypersensitivity_rea1.56063404
43MP0003943_abnormal_hepatobiliary_system1.53620118
44MP0000639_abnormal_adrenal_gland1.52959409
45MP0010155_abnormal_intestine_physiology1.52071605
46MP0003567_abnormal_fetal_cardiomyocyte1.50884693
47MP0002277_abnormal_respiratory_mucosa1.49051671
48MP0003787_abnormal_imprinting1.48284571
49MP0005332_abnormal_amino_acid1.44357652
50MP0003385_abnormal_body_wall1.44074389
51MP0002972_abnormal_cardiac_muscle1.40762892
52MP0002938_white_spotting1.39334525
53MP0005330_cardiomyopathy1.38824318
54MP0004147_increased_porphyrin_level1.35442092
55MP0000749_muscle_degeneration1.34632368
56MP0005409_darkened_coat_color1.32913290
57MP0000049_abnormal_middle_ear1.30099616
58MP0004215_abnormal_myocardial_fiber1.28208937
59MP0001879_abnormal_lymphatic_vessel1.27484133
60MP0010030_abnormal_orbit_morphology1.27449923
61MP0001663_abnormal_digestive_system1.27407001
62MP0004858_abnormal_nervous_system1.23134074
63MP0010352_gastrointestinal_tract_polyps1.21976561
64MP0001727_abnormal_embryo_implantation1.20821736
65MP0005670_abnormal_white_adipose1.19751546
66MP0002163_abnormal_gland_morphology1.19528641
67MP0000477_abnormal_intestine_morphology1.18803967
68MP0000470_abnormal_stomach_morphology1.18494606
69MP0004272_abnormal_basement_membrane1.18251583
70MP0004510_myositis1.17888424
71MP0010368_abnormal_lymphatic_system1.16418443
72MP0005503_abnormal_tendon_morphology1.16298687
73MP0004084_abnormal_cardiac_muscle1.15508847
74MP0005636_abnormal_mineral_homeostasis1.14374221
75MP0009379_abnormal_foot_pigmentation1.13045297
76MP0004484_altered_response_of1.12027654
77MP0005381_digestive/alimentary_phenotyp1.11252653
78MP0003878_abnormal_ear_physiology1.10115842
79MP0005377_hearing/vestibular/ear_phenot1.10115842
80MP0010386_abnormal_urinary_bladder1.09803305
81MP0010234_abnormal_vibrissa_follicle1.09529704
82MP0003693_abnormal_embryo_hatching1.08441930
83MP0009053_abnormal_anal_canal1.08112828
84MP0000538_abnormal_urinary_bladder1.08104608
85MP0006292_abnormal_olfactory_placode1.07874129
86MP0005385_cardiovascular_system_phenoty1.07002543
87MP0001544_abnormal_cardiovascular_syste1.07002543
88MP0002396_abnormal_hematopoietic_system1.05934100
89MP0009384_cardiac_valve_regurgitation1.05555843
90MP0004085_abnormal_heartbeat1.03230221
91MP0003937_abnormal_limbs/digits/tail_de1.02574191
92MP0003866_abnormal_defecation1.01930602
93MP0002282_abnormal_trachea_morphology1.00122536
94MP0000681_abnormal_thyroid_gland0.98542692
95MP0002136_abnormal_kidney_physiology0.93173568
96* MP0005367_renal/urinary_system_phenotyp0.93169881
97* MP0000516_abnormal_urinary_system0.93169881
98MP0009333_abnormal_splenocyte_physiolog0.92883466
99MP0005248_abnormal_Harderian_gland0.91768377
100MP0001835_abnormal_antigen_presentation0.91730555
101MP0002098_abnormal_vibrissa_morphology0.91433543
102MP0003183_abnormal_peptide_metabolism0.89489465
103MP0000762_abnormal_tongue_morphology0.89033443
104MP0000613_abnormal_salivary_gland0.88020655
105MP0008775_abnormal_heart_ventricle0.87819031
106MP0008260_abnormal_autophagy0.87073367
107MP0003724_increased_susceptibility_to0.85355553
108MP0009785_altered_susceptibility_to0.84031669
109MP0000767_abnormal_smooth_muscle0.83885501
110MP0003119_abnormal_digestive_system0.83874374
111MP0008057_abnormal_DNA_replication0.83473358
112MP0005410_abnormal_fertilization0.82346056
113MP0000015_abnormal_ear_pigmentation0.81950434
114MP0005166_decreased_susceptibility_to0.80171689
115MP0009672_abnormal_birth_weight0.80028508
116MP0001730_embryonic_growth_arrest0.78366958
117MP0001175_abnormal_lung_morphology0.78361202
118MP0002118_abnormal_lipid_homeostasis0.77778239
119MP0002089_abnormal_postnatal_growth/wei0.77643274
120MP0003137_abnormal_impulse_conducting0.77079506
121MP0000604_amyloidosis0.75242129
122MP0003566_abnormal_cell_adhesion0.75130140
123MP0000534_abnormal_ureter_morphology0.74883703
124MP0003936_abnormal_reproductive_system0.74771237
125MP0010630_abnormal_cardiac_muscle0.70294687
126MP0000609_abnormal_liver_physiology0.69837858
127MP0005620_abnormal_muscle_contractility0.69016319
128MP0003221_abnormal_cardiomyocyte_apopto0.68960010
129MP0002138_abnormal_hepatobiliary_system0.67668125
130MP0005508_abnormal_skeleton_morphology0.66413438
131MP0001765_abnormal_ion_homeostasis0.66287721
132MP0009764_decreased_sensitivity_to0.65436802
133MP0009250_abnormal_appendicular_skeleto0.65193715
134MP0003879_abnormal_hair_cell0.64992127
135MP0003942_abnormal_urinary_system0.64934677
136MP0008058_abnormal_DNA_repair0.64799019
137MP0002086_abnormal_extraembryonic_tissu0.64406374
138MP0003718_maternal_effect0.63657359
139MP0001764_abnormal_homeostasis0.62316185
140MP0002109_abnormal_limb_morphology0.62100360
141MP0003984_embryonic_growth_retardation0.60475692
142MP0002135_abnormal_kidney_morphology0.59332699
143MP0003329_amyloid_beta_deposits0.59026445
144MP0000467_abnormal_esophagus_morphology0.58944375
145MP0002128_abnormal_blood_circulation0.57660953
146MP0002088_abnormal_embryonic_growth/wei0.56760045
147MP0005666_abnormal_adipose_tissue0.56411735
148MP0002896_abnormal_bone_mineralization0.56362831
149MP0004043_abnormal_pH_regulation0.56347563
150MP0003868_abnormal_feces_composition0.55348048
151MP0002822_catalepsy0.55154719
152MP0003283_abnormal_digestive_organ0.55117955
153MP0002084_abnormal_developmental_patter0.53042895
154MP0001756_abnormal_urination0.51781718

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)5.71299026
2Testicular neoplasm (HP:0010788)4.36241057
3Right ventricular cardiomyopathy (HP:0011663)4.14120442
4Diaphragmatic weakness (HP:0009113)4.11441037
5Congenital sensorineural hearing impairment (HP:0008527)3.79091376
6Hypoplastic left heart (HP:0004383)3.67674892
7Ileus (HP:0002595)3.61256606
8Hypobetalipoproteinemia (HP:0003563)3.58383030
9Stridor (HP:0010307)3.51407189
10Gout (HP:0001997)3.47030986
11Conjugated hyperbilirubinemia (HP:0002908)3.44521984
12Hypolipoproteinemia (HP:0010981)3.37930180
13Acanthocytosis (HP:0001927)3.33492700
14Hyperglycinuria (HP:0003108)3.22932672
15Hypoplastic heart (HP:0001961)3.20966135
16Systemic lupus erythematosus (HP:0002725)3.17625450
17Patent foramen ovale (HP:0001655)3.03869218
18Hyperuricemia (HP:0002149)2.98147690
19Increased purine levels (HP:0004368)2.98147690
20Syringomyelia (HP:0003396)2.97714203
21Spinal cord lesions (HP:0100561)2.97714203
22Male infertility (HP:0003251)2.91518680
23Focal segmental glomerulosclerosis (HP:0000097)2.90992067
24Autoimmune thrombocytopenia (HP:0001973)2.88608745
25Abnormality of vitamin metabolism (HP:0100508)2.87889031
26Abnormal tarsal ossification (HP:0008369)2.80161574
27Hypoalphalipoproteinemia (HP:0003233)2.78719552
28Abnormality of glycine metabolism (HP:0010895)2.76695599
29Abnormality of serine family amino acid metabolism (HP:0010894)2.76695599
30Subacute progressive viral hepatitis (HP:0006572)2.73683459
31Fat malabsorption (HP:0002630)2.72539795
32Metaphyseal dysplasia (HP:0100255)2.62555745
33Abnormality of the vocal cords (HP:0008777)2.62290653
34Aplasia of the musculature (HP:0100854)2.58864362
35Confusion (HP:0001289)2.58839297
36Megaloblastic anemia (HP:0001889)2.58706750
37Anomalous pulmonary venous return (HP:0010772)2.53480050
38Micronodular cirrhosis (HP:0001413)2.52449013
39Abnormal pancreas size (HP:0012094)2.51858143
40Type I transferrin isoform profile (HP:0003642)2.51245840
41Embryonal renal neoplasm (HP:0011794)2.48099750
42Beaking of vertebral bodies (HP:0004568)2.45898833
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.44664532
44Facial diplegia (HP:0001349)2.42159846
45Aplasia cutis congenita (HP:0001057)2.42110991
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41457750
47Ankle clonus (HP:0011448)2.36642919
48Atrial fibrillation (HP:0005110)2.34570458
49Nephrolithiasis (HP:0000787)2.33868156
50Widely patent fontanelles and sutures (HP:0004492)2.33307340
51Vitreoretinal degeneration (HP:0000655)2.33189154
52Skin pits (HP:0100276)2.33176211
53Sex reversal (HP:0012245)2.31657263
54Abnormal sex determination (HP:0012244)2.31657263
55Bulbar palsy (HP:0001283)2.30333038
56Preauricular pit (HP:0004467)2.30258538
57Periauricular skin pits (HP:0100277)2.30258538
58Glomerulosclerosis (HP:0000096)2.28757760
59Pigmentary retinal degeneration (HP:0001146)2.28510768
60Tongue fasciculations (HP:0001308)2.28394429
61Enlarged kidneys (HP:0000105)2.27576780
62Glycosuria (HP:0003076)2.27494040
63Abnormality of urine glucose concentration (HP:0011016)2.27494040
64Osteomalacia (HP:0002749)2.26677154
65Lipoatrophy (HP:0100578)2.26482395
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26142285
67True hermaphroditism (HP:0010459)2.25788993
68Reduced antithrombin III activity (HP:0001976)2.25750944
69Germ cell neoplasia (HP:0100728)2.24314539
70Renal cortical cysts (HP:0000803)2.24194443
71Thin bony cortex (HP:0002753)2.23964460
72Abnormality of proline metabolism (HP:0010907)2.23549108
73Hydroxyprolinuria (HP:0003080)2.23549108
74Palpitations (HP:0001962)2.22329009
75Abdominal distention (HP:0003270)2.22166880
76Ventricular tachycardia (HP:0004756)2.21782209
77Myopathic facies (HP:0002058)2.21349285
78Abnormality of purine metabolism (HP:0004352)2.21326565
79Primary adrenal insufficiency (HP:0008207)2.19118551
80Hyperammonemia (HP:0001987)2.18140800
81Midline defect of the nose (HP:0004122)2.14940573
82Subcapsular cataract (HP:0000523)2.14577054
83Coarctation of aorta (HP:0001680)2.13044093
84Primary atrial arrhythmia (HP:0001692)2.12205315
85Posterior subcapsular cataract (HP:0007787)2.11637277
86Abnormality of the aortic arch (HP:0012303)2.10943973
87Abnormality of the vitamin B12 metabolism (HP:0004341)2.09540164
88Partial duplication of thumb phalanx (HP:0009944)2.09028008
89Hyperglycinemia (HP:0002154)2.08994676
90Abnormal urine phosphate concentration (HP:0012599)2.08852506
91Chromsome breakage (HP:0040012)2.08311373
92Thrombocytosis (HP:0001894)2.07519324
93Transposition of the great arteries (HP:0001669)2.07108970
94Abnormal connection of the cardiac segments (HP:0011545)2.07108970
95Abnormal ventriculo-arterial connection (HP:0011563)2.07108970
96Flat acetabular roof (HP:0003180)2.06569379
97Supraventricular tachycardia (HP:0004755)2.06477222
98Abnormal lung lobation (HP:0002101)2.06358636
99Neoplasm of the tracheobronchial system (HP:0100552)2.03923879
100Chronic diarrhea (HP:0002028)2.02269604
101Villous atrophy (HP:0011473)2.02103440
102Abnormality of small intestinal villus morphology (HP:0011472)2.02103440
103Syncope (HP:0001279)2.01279356
104Upper limb amyotrophy (HP:0009129)1.98385777
105Distal upper limb amyotrophy (HP:0007149)1.98385777
106Mesangial abnormality (HP:0001966)1.97455396
107Malnutrition (HP:0004395)1.97434121
108Supraventricular arrhythmia (HP:0005115)1.97286050
109Abnormality of incisor morphology (HP:0011063)1.97242338
110Muscle fibrillation (HP:0010546)1.95610463
111Nausea (HP:0002018)1.93921441
112Abnormality of the fetal cardiovascular system (HP:0010948)1.93444483
113Abnormal umbilical cord blood vessels (HP:0011403)1.93444483
114Single umbilical artery (HP:0001195)1.93444483
115Prolonged QT interval (HP:0001657)1.93045923
116Neonatal short-limb short stature (HP:0008921)1.91822680
117Hyperphosphaturia (HP:0003109)1.91686481
118Nephroblastoma (Wilms tumor) (HP:0002667)1.91504521
119Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90238202
120Xanthomatosis (HP:0000991)1.88611296
121Hepatoblastoma (HP:0002884)1.87625707
122Amyloidosis (HP:0011034)1.87536101
123Dilated cardiomyopathy (HP:0001644)1.86933040
124Abnormality of nucleobase metabolism (HP:0010932)1.86645792
125Cerebral palsy (HP:0100021)1.85758784
126Hypophosphatemia (HP:0002148)1.85480791
127Abnormality of the pulmonary veins (HP:0011718)1.84968189
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84918658
129Alveolar cell carcinoma (HP:0006519)1.84766603
130Lymphangioma (HP:0100764)1.84415423
131Wide cranial sutures (HP:0010537)1.83870550
132Abnormal biliary tract morphology (HP:0012440)1.83864706
133Male pseudohermaphroditism (HP:0000037)1.83425786
134Myelomeningocele (HP:0002475)1.83160141
135Dry hair (HP:0011359)1.82756865
136Pustule (HP:0200039)1.82488014
137Abnormality of the preputium (HP:0100587)1.82316515
138Glomerulonephritis (HP:0000099)1.81656683
139Abnormality of vitamin B metabolism (HP:0004340)1.80768542
140Proximal tubulopathy (HP:0000114)1.80502030
141White forelock (HP:0002211)1.80436096
142Progressive sensorineural hearing impairment (HP:0000408)1.80309759
143Alopecia of scalp (HP:0002293)1.79704313
144Pulmonary artery stenosis (HP:0004415)1.79478675
145Woolly hair (HP:0002224)1.78708764
146Chorioretinal atrophy (HP:0000533)1.78662805
147Absent eyebrow (HP:0002223)1.75136562
148Hypoalbuminemia (HP:0003073)1.75034791
149Abnormal albumin level (HP:0012116)1.75034791
150Cheilitis (HP:0100825)1.74630041
151Double outlet right ventricle (HP:0001719)1.73601272
152Congenital malformation of the right heart (HP:0011723)1.73601272
153Neoplasm of the liver (HP:0002896)1.73510854
154Partial duplication of the phalanx of hand (HP:0009999)1.71434364
155Asymmetry of the thorax (HP:0001555)1.70632369
156Small intestinal stenosis (HP:0012848)1.69947280
157Duodenal stenosis (HP:0100867)1.69947280
158Microretrognathia (HP:0000308)1.68874435
159Abnormality of the left ventricular outflow tract (HP:0011103)1.68413220
160Subaortic stenosis (HP:0001682)1.68413220
161Meckel diverticulum (HP:0002245)1.67899668
162Delayed epiphyseal ossification (HP:0002663)1.67513151
163Viral hepatitis (HP:0006562)1.64004505
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.63492974
165Hypothermia (HP:0002045)1.62773758
166Symptomatic seizures (HP:0011145)1.61676785
167Bell-shaped thorax (HP:0001591)1.61509597
168Abnormal glycosylation (HP:0012345)1.61270138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.68325755
2PDK24.29748770
3OBSCN4.15546448
4ZAK3.87063557
5TRIB33.79001165
6MYLK3.50493738
7NUAK13.30663387
8STK38L3.18400998
9AKT33.12066277
10ERN13.01742041
11STK242.75990329
12TIE12.75453020
13PRKD32.50915108
14MST42.29731278
15PKN22.24861068
16IRAK32.23474685
17FRK2.15904541
18MAP3K102.00299870
19TXK1.96784215
20PIK3CA1.95405210
21TESK21.94162646
22SIK31.92825535
23STK161.87219671
24MAP3K141.80884627
25LMTK21.63597501
26CDK81.61814637
27TRPM71.59595074
28EPHB21.59477510
29MST1R1.55052916
30PRKG21.54590255
31IRAK41.40801388
32RIPK11.39429601
33NEK91.39009202
34DDR21.38750462
35FGFR41.37312613
36PDGFRA1.29768841
37STK31.29741853
38EIF2AK11.26895468
39PTK61.26239739
40INSRR1.26132428
41CASK1.26126519
42MAP3K21.24392093
43MKNK21.13921271
44NME11.12875792
45YES11.12447097
46PDPK11.11793945
47MKNK11.08798225
48EPHA21.08105360
49PIM21.07625223
50NEK21.04857472
51LATS21.01648405
52LRRK21.01560342
53LATS11.01284517
54MAP2K21.00336016
55VRK10.99098306
56TAOK20.98231648
57BMPR1B0.96636739
58BCR0.95433095
59BRSK20.95149066
60EIF2AK20.94487843
61CDK190.92754283
62GRK10.92098264
63MAP3K10.91236342
64TESK10.89095307
65CDK40.87470993
66PAK40.85927288
67DMPK0.85554453
68MATK0.85464266
69PRPF4B0.85228715
70MAP4K10.84909751
71STK40.84521442
72WNK40.81845635
73MAP2K60.81663906
74NEK60.80967130
75SGK20.80199491
76PRKCI0.79994364
77ILK0.79925277
78FLT30.79881077
79PBK0.79412914
80PLK40.79258701
81SRPK10.78848648
82MAP3K80.72812434
83SMG10.72691948
84MAP3K30.72533570
85PTK20.70421343
86BMPR20.69346650
87CLK10.69056651
88ERBB30.67972038
89TEC0.67901046
90MAP2K30.67774822
91PRKACG0.67196833
92JAK30.65301807
93ERBB40.65288686
94PDK10.64523193
95MAPK130.63028101
96PLK30.61959914
97MAP3K110.60462178
98EPHB10.59565118
99BRD40.58725503
100OXSR10.58029952
101AURKB0.57458337
102ADRBK20.57454682
103ERBB20.56611353
104BRAF0.55778233
105TGFBR10.53454560
106MAPK110.50583640
107RPS6KB10.50571675
108MAP3K120.50020980
109PRKCE0.49854203
110NLK0.48731207
111TYK20.48068377
112CAMK2D0.48036307
113PRKD20.47477862
114MAPK70.47228639
115DYRK1B0.46076306
116GRK60.45590503
117STK100.44202629
118ICK0.43074583
119PRKCA0.42744412
120RET0.42736149
121MELK0.42549208
122BMX0.41806989
123TNIK0.41315427
124CDC42BPA0.40259794
125MET0.39956020
126CDK90.39939640
127IKBKE0.39906963
128CHUK0.39148757
129MARK30.38901823
130TSSK60.38607881
131PIM10.38417744
132ROCK10.37373988
133RPS6KA60.37278784
134PRKCZ0.37247548
135DAPK30.36055206
136CDK70.35874464
137ABL20.35712478
138SGK30.34808363
139STK390.34630911
140EIF2AK30.34132619
141IKBKB0.34123767
142RPS6KC10.33892756
143RPS6KL10.33892756
144PRKAA20.32548704
145CDK120.32001224
146TTK0.30880488
147RPS6KA20.30843792
148PLK10.30536477
149CDK30.29764762
150PLK20.29439478
151SRC0.26881080
152PRKCD0.26669210
153MUSK0.26528501
154PRKACA0.25367272
155MAPKAPK30.23962470

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.70468806
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.57887859
3Vitamin digestion and absorption_Homo sapiens_hsa049773.60455493
4Fat digestion and absorption_Homo sapiens_hsa049753.25269717
5Renin-angiotensin system_Homo sapiens_hsa046143.08965336
6Mineral absorption_Homo sapiens_hsa049783.02409413
7Galactose metabolism_Homo sapiens_hsa000522.92901486
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.86675373
9Fructose and mannose metabolism_Homo sapiens_hsa000512.62264956
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.43723005
11Arginine biosynthesis_Homo sapiens_hsa002202.18348090
12Protein digestion and absorption_Homo sapiens_hsa049741.96962803
13Starch and sucrose metabolism_Homo sapiens_hsa005001.94611607
14PPAR signaling pathway_Homo sapiens_hsa033201.90711446
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78971636
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68246197
17Fatty acid elongation_Homo sapiens_hsa000621.67177164
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56601528
19Chemical carcinogenesis_Homo sapiens_hsa052041.52667442
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52528733
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50950622
22Caffeine metabolism_Homo sapiens_hsa002321.49204514
23Arachidonic acid metabolism_Homo sapiens_hsa005901.46165005
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.45367182
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.43021798
26Linoleic acid metabolism_Homo sapiens_hsa005911.42112595
27Homologous recombination_Homo sapiens_hsa034401.41270613
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37589931
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33061610
30Mismatch repair_Homo sapiens_hsa034301.32454280
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.31696043
32DNA replication_Homo sapiens_hsa030301.31572210
33Glutathione metabolism_Homo sapiens_hsa004801.30922207
34Propanoate metabolism_Homo sapiens_hsa006401.30068162
35Sulfur metabolism_Homo sapiens_hsa009201.28997681
36Folate biosynthesis_Homo sapiens_hsa007901.27578664
37Fanconi anemia pathway_Homo sapiens_hsa034601.27566641
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23872978
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22502459
40Fatty acid degradation_Homo sapiens_hsa000711.19750726
41Base excision repair_Homo sapiens_hsa034101.15405327
42RNA degradation_Homo sapiens_hsa030181.13524734
43Sphingolipid metabolism_Homo sapiens_hsa006001.12535184
44Adherens junction_Homo sapiens_hsa045201.08516309
45Cardiac muscle contraction_Homo sapiens_hsa042601.08116607
46Legionellosis_Homo sapiens_hsa051341.05433216
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03708729
48Carbon metabolism_Homo sapiens_hsa012001.02023991
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.00749363
50Pyruvate metabolism_Homo sapiens_hsa006201.00557425
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00439209
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99770380
53Bile secretion_Homo sapiens_hsa049760.98941381
54Tight junction_Homo sapiens_hsa045300.98771504
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98365326
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98260402
57Glycerolipid metabolism_Homo sapiens_hsa005610.95915377
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93753995
59Hematopoietic cell lineage_Homo sapiens_hsa046400.93686909
60Sulfur relay system_Homo sapiens_hsa041220.93498162
61Dilated cardiomyopathy_Homo sapiens_hsa054140.92641700
62Histidine metabolism_Homo sapiens_hsa003400.91622313
63Leishmaniasis_Homo sapiens_hsa051400.91114736
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90425906
65Purine metabolism_Homo sapiens_hsa002300.88175244
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87111169
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85696744
68Other glycan degradation_Homo sapiens_hsa005110.85019265
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84680657
70Nucleotide excision repair_Homo sapiens_hsa034200.84299060
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83993894
72Ether lipid metabolism_Homo sapiens_hsa005650.83939907
73Tryptophan metabolism_Homo sapiens_hsa003800.83210961
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.83092140
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80945891
76Pyrimidine metabolism_Homo sapiens_hsa002400.80939921
77Fatty acid metabolism_Homo sapiens_hsa012120.80405306
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.79043706
79Allograft rejection_Homo sapiens_hsa053300.77520037
80Herpes simplex infection_Homo sapiens_hsa051680.76659511
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76359915
82Cell cycle_Homo sapiens_hsa041100.73371809
83Parkinsons disease_Homo sapiens_hsa050120.72618382
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72404293
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72005196
86Influenza A_Homo sapiens_hsa051640.71999617
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.70211502
88Basal transcription factors_Homo sapiens_hsa030220.69931762
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69178078
90Graft-versus-host disease_Homo sapiens_hsa053320.68980970
91Peroxisome_Homo sapiens_hsa041460.68832156
92Biosynthesis of amino acids_Homo sapiens_hsa012300.68451091
93Phenylalanine metabolism_Homo sapiens_hsa003600.66429345
94Basal cell carcinoma_Homo sapiens_hsa052170.64809887
95Oxidative phosphorylation_Homo sapiens_hsa001900.64415591
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.63495299
97Hippo signaling pathway_Homo sapiens_hsa043900.62897896
98Protein export_Homo sapiens_hsa030600.61449361
99Autoimmune thyroid disease_Homo sapiens_hsa053200.61285540
100TNF signaling pathway_Homo sapiens_hsa046680.59988093
101Measles_Homo sapiens_hsa051620.56545897
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55321601
103Pertussis_Homo sapiens_hsa051330.55316320
104Proteasome_Homo sapiens_hsa030500.55191243
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54771346
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54491310
107Retinol metabolism_Homo sapiens_hsa008300.53898905
108TGF-beta signaling pathway_Homo sapiens_hsa043500.51801450
109One carbon pool by folate_Homo sapiens_hsa006700.51174309
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50705832
111African trypanosomiasis_Homo sapiens_hsa051430.50370932
112Thyroid cancer_Homo sapiens_hsa052160.48876278
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48204038
114Huntingtons disease_Homo sapiens_hsa050160.47996306
115Hepatitis C_Homo sapiens_hsa051600.47740574
116Salmonella infection_Homo sapiens_hsa051320.46593848
117Complement and coagulation cascades_Homo sapiens_hsa046100.45003597
118RNA polymerase_Homo sapiens_hsa030200.44584769
119ECM-receptor interaction_Homo sapiens_hsa045120.43818771
120Arginine and proline metabolism_Homo sapiens_hsa003300.43002854
121HIF-1 signaling pathway_Homo sapiens_hsa040660.42885303
122Pentose phosphate pathway_Homo sapiens_hsa000300.38673746
123beta-Alanine metabolism_Homo sapiens_hsa004100.38523992
124Insulin resistance_Homo sapiens_hsa049310.38081574
125Non-homologous end-joining_Homo sapiens_hsa034500.36712002
126N-Glycan biosynthesis_Homo sapiens_hsa005100.35078777
127Toxoplasmosis_Homo sapiens_hsa051450.34232150
128Type I diabetes mellitus_Homo sapiens_hsa049400.33778319
129Asthma_Homo sapiens_hsa053100.33718886
130Alzheimers disease_Homo sapiens_hsa050100.33452744
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33384504
132Small cell lung cancer_Homo sapiens_hsa052220.31555398
133Metabolic pathways_Homo sapiens_hsa011000.30504439
134Glucagon signaling pathway_Homo sapiens_hsa049220.29451833
135Amoebiasis_Homo sapiens_hsa051460.29015592
136Apoptosis_Homo sapiens_hsa042100.28605276
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28471951
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26293706
139p53 signaling pathway_Homo sapiens_hsa041150.25139503
140Thyroid hormone synthesis_Homo sapiens_hsa049180.24638060
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24421350
142Pancreatic secretion_Homo sapiens_hsa049720.23687139
143Tyrosine metabolism_Homo sapiens_hsa003500.23165610
144Staphylococcus aureus infection_Homo sapiens_hsa051500.21422455
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19532992
146Butanoate metabolism_Homo sapiens_hsa006500.14899743
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.13982730
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13776708
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11533529
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.11526508
151AMPK signaling pathway_Homo sapiens_hsa041520.11059237
152Renin secretion_Homo sapiens_hsa049240.09373498
153Hedgehog signaling pathway_Homo sapiens_hsa043400.05382897
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.05175886
155ABC transporters_Homo sapiens_hsa020100.05164157
156Melanogenesis_Homo sapiens_hsa049160.00941799
157Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0031157

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