GATAD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.91011762
2histone H3-K4 trimethylation (GO:0080182)4.14203620
3cytoplasmic mRNA processing body assembly (GO:0033962)3.96632154
4histone H3-K9 modification (GO:0061647)3.49610385
5histone H3-K4 methylation (GO:0051568)3.39343770
6nuclear pore complex assembly (GO:0051292)3.32140012
7positive regulation by host of viral transcription (GO:0043923)3.23684850
8regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.22663883
9positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.22663883
10histone H3-K36 demethylation (GO:0070544)3.22608877
11regulation of NFAT protein import into nucleus (GO:0051532)3.20145010
12histone H4-K16 acetylation (GO:0043984)3.16220164
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08807932
14lateral sprouting from an epithelium (GO:0060601)3.06050703
15peptidyl-lysine methylation (GO:0018022)3.04851832
16presynaptic membrane assembly (GO:0097105)3.00703297
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.00405595
18regulation of translation, ncRNA-mediated (GO:0045974)3.00405595
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00405595
20postsynaptic membrane organization (GO:0001941)2.99549666
21positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.97696931
22regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.97696931
23negative regulation of histone methylation (GO:0031061)2.97114121
24monoubiquitinated protein deubiquitination (GO:0035520)2.93201818
25peptidyl-lysine trimethylation (GO:0018023)2.92615532
26pyrimidine nucleobase catabolic process (GO:0006208)2.91262882
27positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.88366651
28presynaptic membrane organization (GO:0097090)2.86413823
29regulation of DNA endoreduplication (GO:0032875)2.86263582
30cell migration in hindbrain (GO:0021535)2.82393053
31positive regulation of CREB transcription factor activity (GO:0032793)2.81774153
32activated T cell proliferation (GO:0050798)2.81444231
33establishment of nucleus localization (GO:0040023)2.81032915
34head development (GO:0060322)2.77282943
35cranial suture morphogenesis (GO:0060363)2.74079207
36regulation of RNA export from nucleus (GO:0046831)2.72224587
37cell differentiation in hindbrain (GO:0021533)2.71467616
38protein demethylation (GO:0006482)2.69487405
39protein dealkylation (GO:0008214)2.69487405
40cerebellar granule cell differentiation (GO:0021707)2.68105779
41positive regulation of granulocyte differentiation (GO:0030854)2.67760415
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66018243
43regulation of mRNA catabolic process (GO:0061013)2.65844052
44histone lysine methylation (GO:0034968)2.64655381
45central nervous system projection neuron axonogenesis (GO:0021952)2.64192301
46regulation of mRNA 3-end processing (GO:0031440)2.62690279
47regulation of ARF protein signal transduction (GO:0032012)2.61897806
48nucleus localization (GO:0051647)2.61057278
49sister chromatid cohesion (GO:0007062)2.58666019
50histone deubiquitination (GO:0016578)2.57783921
51neuron cell-cell adhesion (GO:0007158)2.57131179
52negative T cell selection (GO:0043383)2.51856797
53negative thymic T cell selection (GO:0045060)2.51843757
54craniofacial suture morphogenesis (GO:0097094)2.50108415
55nuclear pore organization (GO:0006999)2.50046740
56positive T cell selection (GO:0043368)2.47524777
57cerebral cortex radially oriented cell migration (GO:0021799)2.45872397
58N-terminal protein amino acid acetylation (GO:0006474)2.45032612
59negative regulation of glial cell proliferation (GO:0060253)2.44789467
60pore complex assembly (GO:0046931)2.43939305
61stress granule assembly (GO:0034063)2.43780178
62positive regulation of mRNA 3-end processing (GO:0031442)2.38710679
63nerve growth factor signaling pathway (GO:0038180)2.37556641
64pre-miRNA processing (GO:0031054)2.37035096
65cardiac ventricle formation (GO:0003211)2.36644623
66embryonic hemopoiesis (GO:0035162)2.35497688
67peptidyl-threonine modification (GO:0018210)2.33304491
68histone H4 acetylation (GO:0043967)2.31759409
69negative regulation of neurotransmitter secretion (GO:0046929)2.31411513
70axonal fasciculation (GO:0007413)2.31376106
71positive regulation of meiosis (GO:0045836)2.30922112
72regulation of nucleobase-containing compound transport (GO:0032239)2.30381905
73establishment of spindle orientation (GO:0051294)2.29807899
74negative regulation of histone modification (GO:0031057)2.29505042
75NLS-bearing protein import into nucleus (GO:0006607)2.28899450
76histone lysine demethylation (GO:0070076)2.27672663
77spinal cord development (GO:0021510)2.26897821
78negative regulation of DNA-dependent DNA replication (GO:2000104)2.26053059
79positive regulation of gamma-delta T cell activation (GO:0046645)2.25723368
80positive regulation of mRNA processing (GO:0050685)2.25108620
81histone H3-K9 methylation (GO:0051567)2.24561641
82interkinetic nuclear migration (GO:0022027)2.24442811
83locomotory exploration behavior (GO:0035641)2.23930955
84regulation of gamma-delta T cell differentiation (GO:0045586)2.23700437
85forebrain neuron differentiation (GO:0021879)2.23318306
86regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.22448146
87histone acetylation (GO:0016573)2.21816348
88negative regulation of keratinocyte proliferation (GO:0010839)2.21622068
89positive regulation of mRNA catabolic process (GO:0061014)2.21313989
90response to interleukin-15 (GO:0070672)2.20644988
91dendrite morphogenesis (GO:0048813)2.19560346
92female gonad development (GO:0008585)2.19153517
93regulation of synaptic vesicle exocytosis (GO:2000300)2.19041244
94regulation of histone methylation (GO:0031060)2.18926086
95intracellular estrogen receptor signaling pathway (GO:0030520)2.18765276
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.18464618
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.18464618
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.18464618
99camera-type eye morphogenesis (GO:0048593)2.17970487
100radial glial cell differentiation (GO:0060019)2.17749545
101fat-soluble vitamin catabolic process (GO:0042363)2.17442025
102vitamin catabolic process (GO:0009111)2.17442025
103positive regulation of cardiac muscle cell differentiation (GO:2000727)2.17331272
104cranial nerve morphogenesis (GO:0021602)2.17044294
105cardiac chamber formation (GO:0003207)2.16778551
106central nervous system neuron axonogenesis (GO:0021955)2.15149301
107regulation of non-canonical Wnt signaling pathway (GO:2000050)2.14288844
108histone methylation (GO:0016571)2.13753361
109neural crest cell development (GO:0014032)2.12877328
110L-amino acid import (GO:0043092)2.12054138
111mRNA splice site selection (GO:0006376)2.10327567
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.10214262
113mesenchymal cell development (GO:0014031)2.08703349
114dendritic spine morphogenesis (GO:0060997)2.08110824
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.07549161
116stem cell development (GO:0048864)2.07399892
117positive regulation of meiotic cell cycle (GO:0051446)2.07125206
118limb bud formation (GO:0060174)2.06465294
119embryonic camera-type eye morphogenesis (GO:0048596)2.06101103
120histone demethylation (GO:0016577)2.06004165
121regulation of keratinocyte proliferation (GO:0010837)2.05842414
122corticosteroid receptor signaling pathway (GO:0031958)2.05240106
123face morphogenesis (GO:0060325)2.04950887
124histone H3-K9 demethylation (GO:0033169)2.04703020
125glucocorticoid receptor signaling pathway (GO:0042921)2.04596751
126positive regulation of gene expression, epigenetic (GO:0045815)2.03103429
127cerebellar Purkinje cell differentiation (GO:0021702)2.00777591
128chondrocyte development (GO:0002063)1.99974284
129ionotropic glutamate receptor signaling pathway (GO:0035235)1.99737884
130heart morphogenesis (GO:0003007)1.99635724
131peptidyl-threonine phosphorylation (GO:0018107)1.99616505
132kinetochore organization (GO:0051383)1.99557171
133negative regulation of neurotransmitter transport (GO:0051589)1.99522800
134somite development (GO:0061053)1.98985491
135asymmetric protein localization (GO:0008105)1.98035122
136neuron recognition (GO:0008038)1.98034826
137regulation of histone H3-K27 methylation (GO:0061085)1.93610798
138somatic stem cell division (GO:0048103)1.93337046
139apical protein localization (GO:0045176)1.93254616
140artery development (GO:0060840)1.93209603
141neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.93040185
142peripheral nervous system axon ensheathment (GO:0032292)1.92375454
143myelination in peripheral nervous system (GO:0022011)1.92375454
144hippo signaling (GO:0035329)1.91376492
145negative regulation of retinoic acid receptor signaling pathway (GO:0048387)1.89523235
146olfactory bulb development (GO:0021772)1.89378988
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.89349597
148regulation of gene expression by genetic imprinting (GO:0006349)1.88246311
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.88241421
150negative regulation of stem cell proliferation (GO:2000647)1.88098466
151regulation of axon extension involved in axon guidance (GO:0048841)1.87672846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.37202448
2GBX2_23144817_ChIP-Seq_PC3_Human2.90875155
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87253663
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.68269795
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.49116530
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21916878
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21518971
8AR_21572438_ChIP-Seq_LNCaP_Human2.16922126
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16463574
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15291422
11MYC_22102868_ChIP-Seq_BL_Human2.08448893
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07875461
13FUS_26573619_Chip-Seq_HEK293_Human2.02297701
14RUNX_20019798_ChIP-Seq_JUKART_Human2.00580447
15DROSHA_22980978_ChIP-Seq_HELA_Human2.00237842
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97613164
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94122284
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.92548746
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89538504
20* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88894382
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.81625754
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80163604
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79861059
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79131902
25TP53_16413492_ChIP-PET_HCT116_Human1.78766075
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77671249
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.76464655
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74047592
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72201350
30EWS_26573619_Chip-Seq_HEK293_Human1.71240564
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71199263
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68316990
33KDM2B_26808549_Chip-Seq_DND41_Human1.68089787
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66408438
35P300_19829295_ChIP-Seq_ESCs_Human1.65980243
36TAF15_26573619_Chip-Seq_HEK293_Human1.65557061
37SMAD4_21799915_ChIP-Seq_A2780_Human1.65550093
38REST_21632747_ChIP-Seq_MESCs_Mouse1.64084029
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61958709
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.60743783
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60268524
42TCF7_22412390_ChIP-Seq_EML_Mouse1.60058833
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59913442
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58083069
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57500424
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.56966373
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53787925
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.50797367
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50473091
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.49319227
51STAT3_23295773_ChIP-Seq_U87_Human1.48672669
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48001058
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47239697
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.45904870
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44799359
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44792077
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44792077
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44130183
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44130183
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43137008
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.42363672
62* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41934739
63AHR_22903824_ChIP-Seq_MCF-7_Human1.41604429
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41069328
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40927087
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38025669
67RNF2_27304074_Chip-Seq_NSC_Mouse1.37828831
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37608830
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37321240
70TCF4_23295773_ChIP-Seq_U87_Human1.36178782
71FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35998404
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35993449
73* KDM2B_26808549_Chip-Seq_K562_Human1.34809456
74IGF1R_20145208_ChIP-Seq_DFB_Human1.34569665
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33859947
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.33302142
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32936626
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.32459208
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.32329167
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32241965
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32034116
82ER_23166858_ChIP-Seq_MCF-7_Human1.30882245
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.29309069
84* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28442261
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.28088636
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27765250
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26892005
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26816619
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.24330261
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24138625
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22463026
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.21819572
93* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20209457
94SCL_19346495_ChIP-Seq_HPC-7_Human1.20046500
95TP53_18474530_ChIP-ChIP_U2OS_Human1.19469091
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19051838
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18642181
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17936814
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17278025
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17066794
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.16293995
102AR_25329375_ChIP-Seq_VCAP_Human1.15756073
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15748945
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14473027
105RXR_22108803_ChIP-Seq_LS180_Human1.14292058
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14269060
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13823141
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13714603
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13015202
110* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12033147
111RUNX2_22187159_ChIP-Seq_PCA_Human1.11321757
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10569571
113JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10476162
114AR_19668381_ChIP-Seq_PC3_Human1.10390385
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10249346
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.09607556
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09299660
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08689503
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08445395
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08281699
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07645782
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.06864188
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06530814
124SOX9_26525672_Chip-Seq_HEART_Mouse1.06455120
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.06048545
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05475584
127CIITA_25753668_ChIP-Seq_RAJI_Human1.05268768
128FOXM1_23109430_ChIP-Seq_U2OS_Human1.05238101
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04933612
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.04627457
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.04616763
132EZH2_27294783_Chip-Seq_ESCs_Mouse1.03360391
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.01967580
134ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01661316
135SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01489217
136* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99758259
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97697325
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95895088
139STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94597350
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.89801514
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88311304
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87876585
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87689450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.12614955
2MP0006292_abnormal_olfactory_placode2.45901346
3MP0005409_darkened_coat_color2.45514997
4MP0000566_synostosis2.36341239
5MP0003121_genomic_imprinting2.34631789
6MP0002009_preneoplasia2.25995033
7MP0000569_abnormal_digit_pigmentation2.24699682
8MP0004381_abnormal_hair_follicle2.15313558
9MP0004859_abnormal_synaptic_plasticity2.11602650
10MP0005171_absent_coat_pigmentation2.05427975
11MP0008961_abnormal_basal_metabolism1.93903705
12MP0009250_abnormal_appendicular_skeleto1.90256808
13MP0003880_abnormal_central_pattern1.87123446
14MP0003763_abnormal_thymus_physiology1.85003917
15MP0003937_abnormal_limbs/digits/tail_de1.80672075
16MP0008057_abnormal_DNA_replication1.79034743
17MP0000778_abnormal_nervous_system1.78638373
18MP0001188_hyperpigmentation1.78047456
19MP0003385_abnormal_body_wall1.75042920
20MP0008877_abnormal_DNA_methylation1.74492794
21MP0003122_maternal_imprinting1.72056902
22MP0003755_abnormal_palate_morphology1.71239351
23MP0008569_lethality_at_weaning1.66139909
24MP0002938_white_spotting1.62880480
25MP0004270_analgesia1.60560389
26MP0003935_abnormal_craniofacial_develop1.56099087
27MP0000703_abnormal_thymus_morphology1.52071864
28MP0003890_abnormal_embryonic-extraembry1.50420748
29MP0004130_abnormal_muscle_cell1.50372793
30MP0005248_abnormal_Harderian_gland1.49589095
31MP0003941_abnormal_skin_development1.45689542
32MP0004808_abnormal_hematopoietic_stem1.43464740
33MP0003136_yellow_coat_color1.39559876
34MP0000383_abnormal_hair_follicle1.37823909
35MP0004811_abnormal_neuron_physiology1.34817276
36MP0001502_abnormal_circadian_rhythm1.32812655
37MP0002249_abnormal_larynx_morphology1.32795848
38MP0000432_abnormal_head_morphology1.30139763
39MP0001346_abnormal_lacrimal_gland1.29483940
40MP0002116_abnormal_craniofacial_bone1.28475323
41MP0001486_abnormal_startle_reflex1.26001374
42MP0002928_abnormal_bile_duct1.25071024
43MP0004742_abnormal_vestibular_system1.23698813
44MP0000428_abnormal_craniofacial_morphol1.21416276
45MP0003635_abnormal_synaptic_transmissio1.21050806
46MP0003938_abnormal_ear_development1.20173272
47MP0000049_abnormal_middle_ear1.18434828
48MP0002177_abnormal_outer_ear1.18381955
49MP0002067_abnormal_sensory_capabilities1.16422271
50MP0001299_abnormal_eye_distance/1.15921999
51MP0002822_catalepsy1.12982142
52MP0000516_abnormal_urinary_system1.12223024
53MP0005367_renal/urinary_system_phenotyp1.12223024
54MP0004142_abnormal_muscle_tone1.11585429
55MP0003045_fibrosis1.11252452
56MP0003943_abnormal_hepatobiliary_system1.11242618
57MP0009384_cardiac_valve_regurgitation1.09284562
58MP0010678_abnormal_skin_adnexa1.09024464
59MP0009703_decreased_birth_body1.09017350
60MP0005076_abnormal_cell_differentiation1.08668184
61MP0003861_abnormal_nervous_system1.08342559
62MP0000631_abnormal_neuroendocrine_gland1.07079394
63MP0002063_abnormal_learning/memory/cond1.06721438
64MP0000579_abnormal_nail_morphology1.06654232
65MP0002572_abnormal_emotion/affect_behav1.04770541
66MP0001286_abnormal_eye_development1.04016135
67MP0004885_abnormal_endolymph1.03480741
68MP0000762_abnormal_tongue_morphology1.03281057
69MP0001293_anophthalmia1.02320127
70MP0005503_abnormal_tendon_morphology0.98393578
71MP0002638_abnormal_pupillary_reflex0.97502479
72MP0009115_abnormal_fat_cell0.97412412
73MP0001943_abnormal_respiration0.97095708
74MP0002272_abnormal_nervous_system0.97044654
75MP0002233_abnormal_nose_morphology0.96955530
76MP0002109_abnormal_limb_morphology0.95680955
77MP0004134_abnormal_chest_morphology0.95036392
78MP0002396_abnormal_hematopoietic_system0.94673153
79MP0000015_abnormal_ear_pigmentation0.92409927
80MP0004185_abnormal_adipocyte_glucose0.92319428
81MP0002102_abnormal_ear_morphology0.91983470
82MP0000733_abnormal_muscle_development0.91617270
83MP0005187_abnormal_penis_morphology0.91363732
84MP0003123_paternal_imprinting0.90350988
85MP0002398_abnormal_bone_marrow0.90291587
86MP0005394_taste/olfaction_phenotype0.90238132
87MP0005499_abnormal_olfactory_system0.90238132
88MP0005645_abnormal_hypothalamus_physiol0.89014848
89MP0001501_abnormal_sleep_pattern0.88097060
90MP0002084_abnormal_developmental_patter0.88067808
91MP0002114_abnormal_axial_skeleton0.87850046
92MP0002085_abnormal_embryonic_tissue0.87729534
93MP0009046_muscle_twitch0.87601953
94MP0000534_abnormal_ureter_morphology0.87251857
95MP0005623_abnormal_meninges_morphology0.87131912
96MP0005386_behavior/neurological_phenoty0.87055100
97MP0004924_abnormal_behavior0.87055100
98MP0008789_abnormal_olfactory_epithelium0.87036255
99MP0001348_abnormal_lacrimal_gland0.86578641
100MP0001340_abnormal_eyelid_morphology0.86389861
101MP0001440_abnormal_grooming_behavior0.85248707
102MP0002082_postnatal_lethality0.85173292
103MP0010770_preweaning_lethality0.85173292
104MP0002925_abnormal_cardiovascular_devel0.85145911
105MP0009053_abnormal_anal_canal0.84169145
106MP0002932_abnormal_joint_morphology0.83568911
107MP0010769_abnormal_survival0.83502940
108MP0000427_abnormal_hair_cycle0.82263742
109MP0003942_abnormal_urinary_system0.82180690
110MP0009745_abnormal_behavioral_response0.81636335
111MP0000647_abnormal_sebaceous_gland0.81524441
112MP0002751_abnormal_autonomic_nervous0.81502941
113MP0005646_abnormal_pituitary_gland0.81001607
114MP0010768_mortality/aging0.80844479
115MP0005508_abnormal_skeleton_morphology0.80788687
116MP0004510_myositis0.79238566
117MP0002081_perinatal_lethality0.78435519
118MP0002152_abnormal_brain_morphology0.78270738
119MP0002735_abnormal_chemical_nociception0.78075440
120MP0002066_abnormal_motor_capabilities/c0.78056917
121MP0010094_abnormal_chromosome_stability0.77393039
122MP0000537_abnormal_urethra_morphology0.76889949
123MP0003948_abnormal_gas_homeostasis0.76449753
124MP0002184_abnormal_innervation0.75606264
125MP0005423_abnormal_somatic_nervous0.75524194
126MP0002095_abnormal_skin_pigmentation0.75483877
127MP0002006_tumorigenesis0.75072098
128MP0002557_abnormal_social/conspecific_i0.74856896
129MP0008995_early_reproductive_senescence0.73825555
130MP0001177_atelectasis0.73746390
131MP0005174_abnormal_tail_pigmentation0.73132021
132MP0002882_abnormal_neuron_morphology0.72421823
133MP0002752_abnormal_somatic_nervous0.71879717
134MP0001851_eye_inflammation0.71236561
135MP0000613_abnormal_salivary_gland0.71129352
136MP0002234_abnormal_pharynx_morphology0.70938005
137MP0002064_seizures0.70705323
138MP0001800_abnormal_humoral_immune0.69612579
139MP0006138_congestive_heart_failure0.69316232
140MP0002163_abnormal_gland_morphology0.69244824
141MP0006276_abnormal_autonomic_nervous0.68685681
142MP0004197_abnormal_fetal_growth/weight/0.67557308
143MP0004145_abnormal_muscle_electrophysio0.67519247
144MP0000955_abnormal_spinal_cord0.67290751
145MP0003115_abnormal_respiratory_system0.67101518

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.40490655
2Abnormality of the fingertips (HP:0001211)3.27336900
3Abnormality of the nasal septum (HP:0000419)3.10584402
4Midline defect of the nose (HP:0004122)3.07634774
5Heterotopia (HP:0002282)2.96640089
6Truncal obesity (HP:0001956)2.90760384
7Short 4th metacarpal (HP:0010044)2.86243559
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.86243559
9Abnormality of the parietal bone (HP:0002696)2.85224151
10Hyperventilation (HP:0002883)2.85086776
11Ectopic kidney (HP:0000086)2.63509965
12Supernumerary ribs (HP:0005815)2.60409410
13Papillary thyroid carcinoma (HP:0002895)2.56037419
14Abnormality of incisor morphology (HP:0011063)2.55008334
15Aqueductal stenosis (HP:0002410)2.49198175
16Trigonocephaly (HP:0000243)2.49185936
17Long eyelashes (HP:0000527)2.49106060
18Lip pit (HP:0100267)2.48181566
19Genetic anticipation (HP:0003743)2.48175464
20Narrow palate (HP:0000189)2.47405358
21Neoplasm of the heart (HP:0100544)2.38530605
22Supernumerary bones of the axial skeleton (HP:0009144)2.34052394
23Chromsome breakage (HP:0040012)2.30759722
24Neonatal hypoglycemia (HP:0001998)2.27579402
25Widely spaced teeth (HP:0000687)2.26872157
26Abnormality of the labia minora (HP:0012880)2.26676319
27Abnormality of the left ventricular outflow tract (HP:0011103)2.24937949
28Subaortic stenosis (HP:0001682)2.24937949
29Abnormal hair whorl (HP:0010721)2.24427052
30Epileptic encephalopathy (HP:0200134)2.23968517
31Abnormality of the columella (HP:0009929)2.23146520
32High anterior hairline (HP:0009890)2.22045760
33Thick eyebrow (HP:0000574)2.18037177
34Increased number of teeth (HP:0011069)2.17108132
35Deep palmar crease (HP:0006191)2.16381860
36Facial hemangioma (HP:0000329)2.14408828
37Papilledema (HP:0001085)2.11137159
38Hypoplastic iliac wings (HP:0002866)2.09279999
39Cupped ear (HP:0000378)2.08274031
40Abnormality of the incisor (HP:0000676)2.03034558
41Sporadic (HP:0003745)2.02874993
42Broad-based gait (HP:0002136)2.01696576
43Oligodactyly (HP:0012165)1.99530421
44Hamartoma (HP:0010566)1.99489427
45Chin dimple (HP:0010751)1.97442737
46Acute myeloid leukemia (HP:0004808)1.97177167
47Oligodactyly (hands) (HP:0001180)1.95797814
48Obstructive sleep apnea (HP:0002870)1.95031085
49Dysmetric saccades (HP:0000641)1.94710635
50Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94254412
51Deep philtrum (HP:0002002)1.93781986
52Sleep apnea (HP:0010535)1.92260530
53Abnormality of chromosome segregation (HP:0002916)1.92005226
54Urinary bladder sphincter dysfunction (HP:0002839)1.89945143
55Focal seizures (HP:0007359)1.89441523
56Tapered finger (HP:0001182)1.88905055
57Abnormality of the intervertebral disk (HP:0005108)1.88599679
58Microglossia (HP:0000171)1.87483015
59Hypoplasia of the maxilla (HP:0000327)1.85763687
60Stereotypic behavior (HP:0000733)1.85690945
61Abnormality of the aortic arch (HP:0012303)1.85302339
62Shallow orbits (HP:0000586)1.85075714
63Abnormality of the 4th metacarpal (HP:0010012)1.84775089
64Abnormality of binocular vision (HP:0011514)1.83834368
65Diplopia (HP:0000651)1.83834368
66Focal motor seizures (HP:0011153)1.82720544
67Adrenal hypoplasia (HP:0000835)1.82637829
68Transitional cell carcinoma of the bladder (HP:0006740)1.82539651
69Acute lymphatic leukemia (HP:0006721)1.81944061
70Febrile seizures (HP:0002373)1.81784819
71Sparse lateral eyebrow (HP:0005338)1.81333361
72Spinal cord lesions (HP:0100561)1.80926414
73Syringomyelia (HP:0003396)1.80926414
74Rib fusion (HP:0000902)1.80759930
75Aplasia cutis congenita (HP:0001057)1.80560595
76Abnormality of the radial head (HP:0003995)1.80558251
77Macroorchidism (HP:0000053)1.80350142
78Abnormal delayed hypersensitivity skin test (HP:0002963)1.80279036
79Deeply set eye (HP:0000490)1.80251161
80Blue irides (HP:0000635)1.79909919
81Absent speech (HP:0001344)1.79767839
82Hypoplastic labia majora (HP:0000059)1.79361846
83Anteriorly placed anus (HP:0001545)1.78676237
84Neoplasm of the adrenal cortex (HP:0100641)1.78063278
85Cutaneous finger syndactyly (HP:0010554)1.77325632
86Abnormality of the phalanges of the hallux (HP:0010057)1.76620528
87Low anterior hairline (HP:0000294)1.76422620
88Laryngomalacia (HP:0001601)1.74144785
89Thickened helices (HP:0000391)1.72731285
90Abnormality of the distal phalanx of the thumb (HP:0009617)1.72291077
91Tracheomalacia (HP:0002779)1.70551473
92Tented upper lip vermilion (HP:0010804)1.69343006
93White forelock (HP:0002211)1.68738778
94Abnormality of the labia majora (HP:0012881)1.68316594
95Increased nuchal translucency (HP:0010880)1.67885143
96Autism (HP:0000717)1.67731805
97Excessive salivation (HP:0003781)1.67711816
98Drooling (HP:0002307)1.67711816
99Broad palm (HP:0001169)1.67454428
100Gaze-evoked nystagmus (HP:0000640)1.67203056
101Germ cell neoplasia (HP:0100728)1.66661952
102Asymmetry of the thorax (HP:0001555)1.66107940
103Postural instability (HP:0002172)1.65880806
104Vertebral arch anomaly (HP:0008438)1.65383837
105Abnormality of the nasolacrimal system (HP:0000614)1.65323948
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.64713814
107Cystic hygroma (HP:0000476)1.63843379
108Neoplasm of the oral cavity (HP:0100649)1.63379058
109Bell-shaped thorax (HP:0001591)1.63143779
110Oligodontia (HP:0000677)1.62374082
111Pheochromocytoma (HP:0002666)1.62313657
112Broad thumb (HP:0011304)1.62237908
113Annular pancreas (HP:0001734)1.62179698
114Shawl scrotum (HP:0000049)1.62081736
115Progressive cerebellar ataxia (HP:0002073)1.61381311
116Microtia (HP:0008551)1.61159779
117Megalencephaly (HP:0001355)1.61062180
118Gastroesophageal reflux (HP:0002020)1.61050314
119Bladder neoplasm (HP:0009725)1.61016656
120Bladder carcinoma (HP:0002862)1.61016656
121Stomach cancer (HP:0012126)1.60765811
122Spina bifida occulta (HP:0003298)1.60743046
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60669280
124Renal hypoplasia (HP:0000089)1.59497058
125Embryonal renal neoplasm (HP:0011794)1.58692890
126Exotropia (HP:0000577)1.58409037
127Long nose (HP:0003189)1.58299285
128Protruding tongue (HP:0010808)1.58093749
129Leiomyosarcoma (HP:0100243)1.57864210
130Uterine leiomyosarcoma (HP:0002891)1.57864210
131Hepatoblastoma (HP:0002884)1.57598856
132Absent frontal sinuses (HP:0002688)1.57185541
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56447231
134Obsessive-compulsive behavior (HP:0000722)1.55925406
135Prostate neoplasm (HP:0100787)1.54553132
136Anal stenosis (HP:0002025)1.54437149
137Urethral obstruction (HP:0000796)1.54053630
138Depressed nasal tip (HP:0000437)1.53391829
139Nephroblastoma (Wilms tumor) (HP:0002667)1.53030026
140Cutaneous syndactyly (HP:0012725)1.52870127
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.51281794
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.51281794
143Synophrys (HP:0000664)1.49714865
144Highly arched eyebrow (HP:0002553)1.47914780
145Dislocated radial head (HP:0003083)1.46679103
146Thyroid carcinoma (HP:0002890)1.46247683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.68213839
2CDK123.52686354
3BRD42.43959167
4DMPK2.42728256
5NUAK12.25950428
6EPHA32.17079068
7CAMK1G2.11021911
8MAP3K101.97713116
9ICK1.92061315
10PRPF4B1.85208239
11FGFR21.75054494
12EPHA41.66885227
13NTRK31.60150423
14CSNK1A1L1.60079088
15STK31.58177881
16SGK21.58013750
17MAPK131.55827550
18WNK11.53591599
19PNCK1.51364055
20AKT31.50738705
21CDC71.43601378
22CASK1.43040318
23TNIK1.41696692
24CAMK1D1.38994306
25LATS21.37903938
26RIPK41.35094755
27CDK31.34058699
28NEK61.33577343
29SGK31.29877333
30TAOK31.20588423
31MKNK21.20368536
32PRKD21.19942973
33PLK21.19767279
34EEF2K1.15169953
35CDK91.13473877
36TYRO31.13303516
37TNK21.10610051
38CHEK21.10589024
39MARK21.09835127
40CSNK1G11.09469790
41SGK4941.08244081
42SGK2231.08244081
43CAMKK11.06969477
44TRIB31.06809953
45MAP3K41.05600933
46MAP3K61.05313253
47MAP3K71.04755536
48CSNK1G21.03740676
49NTRK21.03543552
50MAP2K71.02666079
51MKNK11.01088342
52MARK10.99713447
53ZAK0.98076340
54MARK30.96844496
55PDGFRB0.95561470
56SIK10.94792499
57SIK30.94640396
58NLK0.90639189
59BCR0.90397644
60FGFR30.90229756
61STK38L0.89627602
62STK240.89522898
63PLK40.88203369
64CSNK1G30.83733316
65MAP4K10.83524830
66RET0.83414773
67ATM0.83289087
68PIK3CA0.83028721
69MELK0.82959323
70STK390.81379480
71CHEK10.80567489
72TAOK10.80212869
73SGK10.80158424
74PLK30.78428767
75FRK0.77385141
76CSNK1D0.75952137
77PKN10.75755223
78MAPK100.73226874
79MAPK70.73050390
80CDK60.71844155
81BMPR1B0.71143674
82EPHB10.70747791
83INSRR0.70679112
84MAPK120.69623512
85FES0.66785999
86BMPR20.65999209
87GSK3B0.65248275
88HIPK20.65124483
89PRKCQ0.65001405
90SMG10.63882961
91CDK10.63032101
92TXK0.62610668
93MAPK140.62428109
94STK380.62403248
95SRPK10.62272450
96SIK20.61829933
97MAP3K20.61050597
98IRAK10.60522077
99BTK0.59885376
100HCK0.59608538
101CLK10.59028635
102CDK20.58470715
103YES10.58090994
104ERBB30.57835027
105CDK80.57547989
106CDK50.56946632
107STK110.56687102
108DYRK1A0.56625336
109DYRK20.56486709
110MTOR0.56242654
111CHUK0.56074736
112UHMK10.54164812
113ALK0.53606515
114PRKCH0.53052254
115MAP3K90.52374897
116MAPK80.51405705
117KSR10.50465390
118MINK10.49985143
119DYRK1B0.49832021
120TAF10.49776099
121KSR20.49621191
122CSNK1E0.49126037
123CSNK1A10.46986646
124CDC42BPA0.46504288
125JAK20.46395375
126PRKAA10.45915318
127CDK40.45902611
128BRSK20.45106391
129PRKCE0.45021131
130CAMK40.44832809
131SYK0.44618244
132PRKCZ0.44252779
133CAMK10.44120136
134MAPK10.42750834
135MAP3K130.40504470
136PRKD30.39554820
137MAP2K40.39023976
138AKT10.38962854
139JAK10.38366598
140PAK30.37755883
141RPS6KA30.37265601
142ITK0.37001453
143PKN20.36437598
144FGFR40.35705401

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052211.71634899
2Axon guidance_Homo sapiens_hsa043601.69971843
3Nicotine addiction_Homo sapiens_hsa050331.66978152
4Long-term potentiation_Homo sapiens_hsa047201.61186764
5Wnt signaling pathway_Homo sapiens_hsa043101.51680077
6Glutamatergic synapse_Homo sapiens_hsa047241.51474546
7Dorso-ventral axis formation_Homo sapiens_hsa043201.48039845
8Adherens junction_Homo sapiens_hsa045201.41134704
9MicroRNAs in cancer_Homo sapiens_hsa052061.40658346
10Thyroid cancer_Homo sapiens_hsa052161.37664284
11Long-term depression_Homo sapiens_hsa047301.34923576
12Inositol phosphate metabolism_Homo sapiens_hsa005621.32391776
13Basal cell carcinoma_Homo sapiens_hsa052171.31517062
14mTOR signaling pathway_Homo sapiens_hsa041501.29363964
15Amphetamine addiction_Homo sapiens_hsa050311.27970323
16Hedgehog signaling pathway_Homo sapiens_hsa043401.26523162
17Circadian entrainment_Homo sapiens_hsa047131.25581900
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23768067
19TGF-beta signaling pathway_Homo sapiens_hsa043501.23512813
20ErbB signaling pathway_Homo sapiens_hsa040121.22986082
21Prostate cancer_Homo sapiens_hsa052151.20634378
22Colorectal cancer_Homo sapiens_hsa052101.20260680
23Prolactin signaling pathway_Homo sapiens_hsa049171.19335924
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18702515
25Renin secretion_Homo sapiens_hsa049241.17566821
26Serotonergic synapse_Homo sapiens_hsa047261.16851489
27Endometrial cancer_Homo sapiens_hsa052131.16670904
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16138076
29Renal cell carcinoma_Homo sapiens_hsa052111.14683203
30Choline metabolism in cancer_Homo sapiens_hsa052311.14562633
31Cell cycle_Homo sapiens_hsa041101.14339953
32Non-homologous end-joining_Homo sapiens_hsa034501.13487288
33Morphine addiction_Homo sapiens_hsa050321.13134608
34Glioma_Homo sapiens_hsa052141.13043236
35Dopaminergic synapse_Homo sapiens_hsa047281.10373652
36Hippo signaling pathway_Homo sapiens_hsa043901.07709710
37cAMP signaling pathway_Homo sapiens_hsa040241.07656524
38Oxytocin signaling pathway_Homo sapiens_hsa049211.07054390
39Fanconi anemia pathway_Homo sapiens_hsa034601.06128523
40Cholinergic synapse_Homo sapiens_hsa047251.06119728
41MAPK signaling pathway_Homo sapiens_hsa040101.05332424
42Phototransduction_Homo sapiens_hsa047441.04723947
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04699514
44Pancreatic cancer_Homo sapiens_hsa052121.03772623
45Olfactory transduction_Homo sapiens_hsa047401.01388856
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99765597
47Melanogenesis_Homo sapiens_hsa049160.99632129
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98895904
49T cell receptor signaling pathway_Homo sapiens_hsa046600.98861308
50mRNA surveillance pathway_Homo sapiens_hsa030150.98142628
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97471110
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97414752
53Ras signaling pathway_Homo sapiens_hsa040140.96430727
54GnRH signaling pathway_Homo sapiens_hsa049120.96230372
55Salivary secretion_Homo sapiens_hsa049700.96148936
56Measles_Homo sapiens_hsa051620.95910925
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94666746
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92784212
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92438180
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90205985
61Basal transcription factors_Homo sapiens_hsa030220.89069033
62Oocyte meiosis_Homo sapiens_hsa041140.88885724
63Chronic myeloid leukemia_Homo sapiens_hsa052200.88845008
64FoxO signaling pathway_Homo sapiens_hsa040680.87779545
65Melanoma_Homo sapiens_hsa052180.86890513
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86862988
67RNA degradation_Homo sapiens_hsa030180.86860116
68Cocaine addiction_Homo sapiens_hsa050300.86331259
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86165953
70Non-small cell lung cancer_Homo sapiens_hsa052230.85518826
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84730701
72Osteoclast differentiation_Homo sapiens_hsa043800.84672256
73Circadian rhythm_Homo sapiens_hsa047100.84278590
74Rap1 signaling pathway_Homo sapiens_hsa040150.84262845
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.83790084
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83527972
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83361126
78Pathways in cancer_Homo sapiens_hsa052000.82646660
79GABAergic synapse_Homo sapiens_hsa047270.82492703
80Notch signaling pathway_Homo sapiens_hsa043300.82059981
81B cell receptor signaling pathway_Homo sapiens_hsa046620.79880450
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79723067
83Gap junction_Homo sapiens_hsa045400.78882110
84Type II diabetes mellitus_Homo sapiens_hsa049300.78630038
85Dilated cardiomyopathy_Homo sapiens_hsa054140.78497464
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78314450
87Viral myocarditis_Homo sapiens_hsa054160.78161240
88Ovarian steroidogenesis_Homo sapiens_hsa049130.77787934
89Estrogen signaling pathway_Homo sapiens_hsa049150.77723331
90Calcium signaling pathway_Homo sapiens_hsa040200.77403472
91Taste transduction_Homo sapiens_hsa047420.77222573
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76732322
93Proteoglycans in cancer_Homo sapiens_hsa052050.76580311
94Insulin signaling pathway_Homo sapiens_hsa049100.76261724
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76254927
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76252081
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76016460
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.75654494
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.75349976
100Gastric acid secretion_Homo sapiens_hsa049710.74413341
101Hepatitis B_Homo sapiens_hsa051610.73553229
102Lysine degradation_Homo sapiens_hsa003100.73145333
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73091820
104VEGF signaling pathway_Homo sapiens_hsa043700.72994386
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.72430931
106Insulin secretion_Homo sapiens_hsa049110.72156488
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72065578
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71218838
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70739044
110AMPK signaling pathway_Homo sapiens_hsa041520.70511188
111Platelet activation_Homo sapiens_hsa046110.69411235
112Focal adhesion_Homo sapiens_hsa045100.69160064
113HTLV-I infection_Homo sapiens_hsa051660.68461153
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.68143842
115Viral carcinogenesis_Homo sapiens_hsa052030.67951086
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67554649
117Chemokine signaling pathway_Homo sapiens_hsa040620.67380139
118Tight junction_Homo sapiens_hsa045300.66090458
119Insulin resistance_Homo sapiens_hsa049310.61579764
120Primary immunodeficiency_Homo sapiens_hsa053400.61040820
121Influenza A_Homo sapiens_hsa051640.55937483
122HIF-1 signaling pathway_Homo sapiens_hsa040660.55043367

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