GATB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.75175625
2L-phenylalanine catabolic process (GO:0006559)6.75175625
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.61396592
4L-phenylalanine metabolic process (GO:0006558)6.61396592
5aromatic amino acid family catabolic process (GO:0009074)6.34085426
6indole-containing compound catabolic process (GO:0042436)5.87464045
7indolalkylamine catabolic process (GO:0046218)5.87464045
8tryptophan catabolic process (GO:0006569)5.87464045
9glyoxylate metabolic process (GO:0046487)5.72874775
10tryptophan metabolic process (GO:0006568)5.51652958
11cellular ketone body metabolic process (GO:0046950)5.45811153
12kynurenine metabolic process (GO:0070189)5.44983508
13lysine catabolic process (GO:0006554)5.22355775
14lysine metabolic process (GO:0006553)5.22355775
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14753627
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07672394
17bile acid biosynthetic process (GO:0006699)4.94439868
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79190716
19cysteine metabolic process (GO:0006534)4.78809324
20ketone body metabolic process (GO:1902224)4.71768658
21aromatic amino acid family metabolic process (GO:0009072)4.70704575
22amino-acid betaine metabolic process (GO:0006577)4.66346012
23serine family amino acid catabolic process (GO:0009071)4.64098824
24urea cycle (GO:0000050)4.58333423
25urea metabolic process (GO:0019627)4.58333423
26regulation of mitochondrial translation (GO:0070129)4.57942558
27alpha-amino acid catabolic process (GO:1901606)4.56744189
28short-chain fatty acid metabolic process (GO:0046459)4.56491268
29energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49424259
30ATP synthesis coupled proton transport (GO:0015986)4.49424259
31fatty acid beta-oxidation (GO:0006635)4.44161431
32alpha-linolenic acid metabolic process (GO:0036109)4.44069676
33homocysteine metabolic process (GO:0050667)4.35212039
34branched-chain amino acid catabolic process (GO:0009083)4.32831263
35indolalkylamine metabolic process (GO:0006586)4.30079136
36sulfur amino acid catabolic process (GO:0000098)4.27796264
37amine catabolic process (GO:0009310)4.26605771
38cellular biogenic amine catabolic process (GO:0042402)4.26605771
39cellular amino acid catabolic process (GO:0009063)4.26003879
40aspartate family amino acid catabolic process (GO:0009068)4.24725093
41nitrogen cycle metabolic process (GO:0071941)4.23912073
42bile acid metabolic process (GO:0008206)4.22129177
43fatty acid oxidation (GO:0019395)4.20388457
44high-density lipoprotein particle remodeling (GO:0034375)4.18769755
45fatty acid catabolic process (GO:0009062)4.16927656
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16876668
47tyrosine metabolic process (GO:0006570)4.16414046
48acetyl-CoA metabolic process (GO:0006084)4.15904159
49regulation of triglyceride catabolic process (GO:0010896)4.14696083
50coenzyme catabolic process (GO:0009109)4.14134417
51cellular glucuronidation (GO:0052695)4.13324653
52lipid oxidation (GO:0034440)4.11412538
532-oxoglutarate metabolic process (GO:0006103)4.10818670
54monocarboxylic acid catabolic process (GO:0072329)4.06393252
55aldehyde catabolic process (GO:0046185)4.05144124
56branched-chain amino acid metabolic process (GO:0009081)4.03385334
57organic acid catabolic process (GO:0016054)4.03170457
58carboxylic acid catabolic process (GO:0046395)4.03170457
59oxidative phosphorylation (GO:0006119)4.00018675
60respiratory electron transport chain (GO:0022904)3.97439200
61drug transmembrane transport (GO:0006855)3.96824586
62chaperone-mediated protein transport (GO:0072321)3.95786545
63regulation of fibrinolysis (GO:0051917)3.95207928
64mitochondrial respiratory chain complex assembly (GO:0033108)3.92023832
65carnitine metabolic process (GO:0009437)3.91275957
66ethanol oxidation (GO:0006069)3.90980140
67protein complex biogenesis (GO:0070271)3.90400622
68electron transport chain (GO:0022900)3.89486028
69negative regulation of fibrinolysis (GO:0051918)3.88994355
70serine family amino acid metabolic process (GO:0009069)3.88740328
71glutamate metabolic process (GO:0006536)3.88675641
72glucuronate metabolic process (GO:0019585)3.88137220
73uronic acid metabolic process (GO:0006063)3.88137220
74complement activation, alternative pathway (GO:0006957)3.84437269
75acylglycerol homeostasis (GO:0055090)3.83612089
76triglyceride homeostasis (GO:0070328)3.83612089
77valine metabolic process (GO:0006573)3.83424458
78cellular modified amino acid catabolic process (GO:0042219)3.80117223
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.79987195
80NADH dehydrogenase complex assembly (GO:0010257)3.79987195
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79987195
82NAD biosynthetic process (GO:0009435)3.79597591
83regulation of protein activation cascade (GO:2000257)3.79103832
84drug catabolic process (GO:0042737)3.78784541
85glycine metabolic process (GO:0006544)3.76117910
86protein carboxylation (GO:0018214)3.75908614
87peptidyl-glutamic acid carboxylation (GO:0017187)3.75908614
88urate metabolic process (GO:0046415)3.74228827
89dicarboxylic acid biosynthetic process (GO:0043650)3.73080103
90respiratory chain complex IV assembly (GO:0008535)3.72251927
91arginine metabolic process (GO:0006525)3.72070835
92tricarboxylic acid cycle (GO:0006099)3.68234186
93cullin deneddylation (GO:0010388)3.66613517
94regulation of cholesterol esterification (GO:0010872)3.66598974
95serine family amino acid biosynthetic process (GO:0009070)3.64312608
96benzene-containing compound metabolic process (GO:0042537)3.62235852
97imidazole-containing compound metabolic process (GO:0052803)3.59699462
98plasma lipoprotein particle clearance (GO:0034381)3.59044769
99protein-lipid complex remodeling (GO:0034368)3.57861415
100macromolecular complex remodeling (GO:0034367)3.57861415
101plasma lipoprotein particle remodeling (GO:0034369)3.57861415
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.57260016
103pyridine nucleotide biosynthetic process (GO:0019363)3.57260016
104reverse cholesterol transport (GO:0043691)3.55466829
105bile acid and bile salt transport (GO:0015721)3.55331643
106ubiquinone biosynthetic process (GO:0006744)3.53756375
107regulation of complement activation (GO:0030449)3.50700819
108biotin metabolic process (GO:0006768)3.49302647
109protein deneddylation (GO:0000338)3.47220192
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47094930
111small molecule catabolic process (GO:0044282)3.47001646
112NAD metabolic process (GO:0019674)3.45012988
113flavonoid metabolic process (GO:0009812)3.44894650
114cofactor catabolic process (GO:0051187)3.42251750
115phospholipid efflux (GO:0033700)3.41199855
116exogenous drug catabolic process (GO:0042738)3.40906230
117fructose metabolic process (GO:0006000)3.39404480
118succinate metabolic process (GO:0006105)3.34659955
119pyrimidine nucleoside catabolic process (GO:0046135)3.32009519
120negative regulation of lipase activity (GO:0060192)3.31176730
121ubiquinone metabolic process (GO:0006743)3.31130676
122cytochrome complex assembly (GO:0017004)3.26418366
123establishment of protein localization to mitochondrial membrane (GO:0090151)3.26165971
124proteasome assembly (GO:0043248)3.22132633
125protein targeting to mitochondrion (GO:0006626)3.20080375
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16045844
127mitochondrial RNA metabolic process (GO:0000959)3.12575335
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09480161
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09480161
130maturation of 5.8S rRNA (GO:0000460)3.08180110
131DNA double-strand break processing (GO:0000729)3.03920085
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00135116
133regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95829686
134protein localization to mitochondrion (GO:0070585)2.93280704
135establishment of protein localization to mitochondrion (GO:0072655)2.93271105
136transcription elongation from RNA polymerase III promoter (GO:0006385)2.92990607
137termination of RNA polymerase III transcription (GO:0006386)2.92990607
138regulation of cellular amino acid metabolic process (GO:0006521)2.92692625
139amino acid salvage (GO:0043102)2.91908702
140L-methionine salvage (GO:0071267)2.91908702
141L-methionine biosynthetic process (GO:0071265)2.91908702
142quinone biosynthetic process (GO:1901663)2.91528557
143ribosome assembly (GO:0042255)2.90979601
144negative regulation of ligase activity (GO:0051352)2.90956260
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90956260
146rRNA modification (GO:0000154)2.88833318
147aerobic respiration (GO:0009060)2.87641787
148ATP biosynthetic process (GO:0006754)2.87224635
149anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86690611
150DNA catabolic process, exonucleolytic (GO:0000738)2.85017710
151pseudouridine synthesis (GO:0001522)2.81603638
152cellular component biogenesis (GO:0044085)2.81231574
153spliceosomal snRNP assembly (GO:0000387)2.80372598
154ribosome biogenesis (GO:0042254)2.77366802
155IMP biosynthetic process (GO:0006188)2.77302299
156protein-cofactor linkage (GO:0018065)2.77142219
157inner mitochondrial membrane organization (GO:0007007)2.76703808
158hydrogen ion transmembrane transport (GO:1902600)2.75703015
159water-soluble vitamin biosynthetic process (GO:0042364)2.75596162
160iron-sulfur cluster assembly (GO:0016226)2.75170350
161metallo-sulfur cluster assembly (GO:0031163)2.75170350
162regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75127474
163amino acid activation (GO:0043038)2.72372479
164tRNA aminoacylation (GO:0043039)2.72372479
165establishment of integrated proviral latency (GO:0075713)2.72326529
166tRNA aminoacylation for protein translation (GO:0006418)2.72256701
167purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.71940708
168purine nucleoside monophosphate biosynthetic process (GO:0009127)2.71940708
169DNA strand elongation involved in DNA replication (GO:0006271)2.71822844
170DNA damage response, detection of DNA damage (GO:0042769)2.68036958
171purine nucleobase biosynthetic process (GO:0009113)2.67863965
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67571151
173purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67380041
174positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66824766
175purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65936882
176maturation of SSU-rRNA (GO:0030490)2.65340060
177peptidyl-histidine modification (GO:0018202)2.63930446
178signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63451401
179signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63451401
180signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63451401
181chromatin remodeling at centromere (GO:0031055)2.62495463
182cellular respiration (GO:0045333)2.61701588
183ATP hydrolysis coupled proton transport (GO:0015991)2.61444561
184energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61444561
185intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61181332
186signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61181332
187mitochondrial transport (GO:0006839)2.60789130
188telomere maintenance via semi-conservative replication (GO:0032201)2.60227905
189DNA strand elongation (GO:0022616)2.60105626
190regulation of coenzyme metabolic process (GO:0051196)2.58330008
191regulation of cofactor metabolic process (GO:0051193)2.58330008
192nucleobase biosynthetic process (GO:0046112)2.57404622
193signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56883317
194signal transduction involved in DNA damage checkpoint (GO:0072422)2.56883317
195positive regulation of ligase activity (GO:0051351)2.56619405
196tRNA metabolic process (GO:0006399)2.56186612
197ribonucleoside triphosphate biosynthetic process (GO:0009201)2.55378457
198transcription from mitochondrial promoter (GO:0006390)2.54378028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.87225170
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.80835248
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.05191655
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.80803013
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.79726113
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.24574606
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80439194
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.52370647
9GABP_17652178_ChIP-ChIP_JURKAT_Human4.28583901
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.95034302
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81619632
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.55678958
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41370851
14E2F7_22180533_ChIP-Seq_HELA_Human3.33600229
15MYC_18555785_ChIP-Seq_MESCs_Mouse3.31876789
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29769904
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.07883662
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00336769
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70452604
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67730568
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.66667877
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56581283
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35483512
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35072690
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29917422
26GABP_19822575_ChIP-Seq_HepG2_Human2.28573853
27VDR_23849224_ChIP-Seq_CD4+_Human2.25135651
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21508519
29DCP1A_22483619_ChIP-Seq_HELA_Human2.20017734
30ELK1_19687146_ChIP-ChIP_HELA_Human2.18854684
31FOXP3_21729870_ChIP-Seq_TREG_Human2.15644700
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15416434
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.10070277
34XRN2_22483619_ChIP-Seq_HELA_Human2.06675884
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06082887
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02504083
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.96333241
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94431617
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90514589
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89893163
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89448639
42TTF2_22483619_ChIP-Seq_HELA_Human1.87315208
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85255286
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77183690
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76623109
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74538140
47HTT_18923047_ChIP-ChIP_STHdh_Human1.73623245
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73009111
49TAF15_26573619_Chip-Seq_HEK293_Human1.65759151
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59572240
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59025532
52GBX2_23144817_ChIP-Seq_PC3_Human1.52011426
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48369209
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46941156
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46617447
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43157478
57ZNF274_21170338_ChIP-Seq_K562_Hela1.41443524
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37968058
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37177390
60MYC_18940864_ChIP-ChIP_HL60_Human1.35122495
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34175263
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.33372561
63IGF1R_20145208_ChIP-Seq_DFB_Human1.32035385
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26934506
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25736737
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25699084
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25248872
68VDR_22108803_ChIP-Seq_LS180_Human1.20110347
69KDM5A_27292631_Chip-Seq_BREAST_Human1.18795627
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18255107
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17207338
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.11873032
73* CIITA_25753668_ChIP-Seq_RAJI_Human1.10607283
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08862332
75HNF4A_19822575_ChIP-Seq_HepG2_Human1.08365849
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06684459
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05329095
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01444489
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01118188
80IRF1_19129219_ChIP-ChIP_H3396_Human1.00529489
81ZNF263_19887448_ChIP-Seq_K562_Human1.00414788
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00404469
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.99043314
84TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98757762
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98416053
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97865193
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97457053
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96947383
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.96703273
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96522570
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95626261
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94496786
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93936637
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92483416
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91272408
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89197089
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87933703
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87794659
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87692769
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86287240
101TFEB_21752829_ChIP-Seq_HELA_Human0.85960800
102AR_20517297_ChIP-Seq_VCAP_Human0.85871824
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84746987
104EZH2_27294783_Chip-Seq_NPCs_Mouse0.84321887
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.84230083
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83300247
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83235667
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81604699
109FOXM1_23109430_ChIP-Seq_U2OS_Human0.81397065
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80324111
111NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79879901
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79804580
113AR_21909140_ChIP-Seq_LNCAP_Human0.79478403
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79110052
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.78498029
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77392690
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.76026093
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75836560
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75374712
120EOMES_21245162_ChIP-Seq_HESCs_Human0.74763356
121CRX_20693478_ChIP-Seq_RETINA_Mouse0.74329591
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74271059
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74219252
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73940119
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73808388
126GATA4_21415370_ChIP-Seq_HL-1_Mouse0.73405942
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73047113
128TP53_22573176_ChIP-Seq_HFKS_Human0.72709756
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72274635
130STAT1_17558387_ChIP-Seq_HELA_Human0.72100271
131BCAT_22108803_ChIP-Seq_LS180_Human0.72076647
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.71796882
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71674943
134RUNX1_27457419_Chip-Seq_LIVER_Mouse0.71291569
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70955708
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.70603548
137CBP_21632823_ChIP-Seq_H3396_Human0.70112510
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69366549
139P300_19829295_ChIP-Seq_ESCs_Human0.68756430
140ERG_20517297_ChIP-Seq_VCAP_Human0.68158013
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.67710675
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.66142539
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.64452516
144NANOG_19829295_ChIP-Seq_ESCs_Human0.61952622
145SOX2_19829295_ChIP-Seq_ESCs_Human0.61952622
146ER_23166858_ChIP-Seq_MCF-7_Human0.61033928
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60304296
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60248444
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60248444
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.59782682
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.58764442
152TAF2_19829295_ChIP-Seq_ESCs_Human0.58078426
153YY1_21170310_ChIP-Seq_MESCs_Mouse0.58032223
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.57109107
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.56860817
156SOX2_22085726_ChIP-Seq_NPCs_Mouse0.56720466
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.56704527
158OCT4_21477851_ChIP-Seq_ESCs_Mouse0.56615493
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.56395616
160SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55848456
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.55628937
162P53_22387025_ChIP-Seq_ESCs_Mouse0.55544409
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.55383599
164CEBPB_22108803_ChIP-Seq_LS180_Human0.54573778
165NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.54532814
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54297104
167STAT3_18555785_Chip-Seq_ESCs_Mouse0.53469810
168P53_21459846_ChIP-Seq_SAOS-2_Human0.53266736
169EP300_21415370_ChIP-Seq_HL-1_Mouse0.53135537
170FOXH1_21741376_ChIP-Seq_EPCs_Human0.53028330
171OCT4_18555785_Chip-Seq_ESCs_Mouse0.52309224
172ETV2_25802403_ChIP-Seq_MESCs_Mouse0.52231311
173RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.52219058
174TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51995386
175NCOR_22424771_ChIP-Seq_293T_Human0.51347982
176PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.51278350
177P300_18555785_Chip-Seq_ESCs_Mouse0.51149031
178PU1_27457419_Chip-Seq_LIVER_Mouse0.51143482
179TAL1_26923725_Chip-Seq_HPCs_Mouse0.50650816
180PHF8_20622853_ChIP-Seq_HELA_Human0.50425740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.25170540
2MP0005360_urolithiasis6.87566284
3MP0005085_abnormal_gallbladder_physiolo5.77087967
4MP0005365_abnormal_bile_salt5.25682115
5MP0008875_abnormal_xenobiotic_pharmacok4.46855481
6MP0003806_abnormal_nucleotide_metabolis4.18106403
7MP0005332_abnormal_amino_acid3.24444068
8MP0008058_abnormal_DNA_repair3.15106067
9MP0003195_calcinosis3.14749553
10MP0003252_abnormal_bile_duct3.04254879
11MP0010329_abnormal_lipoprotein_level2.90154615
12MP0010094_abnormal_chromosome_stability2.56620765
13MP0002837_dystrophic_cardiac_calcinosis2.53607834
14MP0004019_abnormal_vitamin_homeostasis2.36392934
15MP0005451_abnormal_body_composition2.33960435
16MP0003693_abnormal_embryo_hatching2.31822554
17MP0003880_abnormal_central_pattern2.29984440
18MP0005083_abnormal_biliary_tract2.22330989
19MP0009840_abnormal_foam_cell2.18069666
20MP0001764_abnormal_homeostasis2.12580030
21MP0009046_muscle_twitch2.08401100
22MP0001666_abnormal_nutrient_absorption2.03469596
23MP0002118_abnormal_lipid_homeostasis2.02286523
24MP0006036_abnormal_mitochondrial_physio1.98694339
25MP0003111_abnormal_nucleus_morphology1.96957707
26MP0000372_irregular_coat_pigmentation1.95799973
27MP0005584_abnormal_enzyme/coenzyme_acti1.81512704
28MP0003646_muscle_fatigue1.79043954
29MP0005319_abnormal_enzyme/_coenzyme1.78313633
30MP0009697_abnormal_copulation1.76687707
31MP0005670_abnormal_white_adipose1.73340317
32MP0000609_abnormal_liver_physiology1.72577240
33MP0003186_abnormal_redox_activity1.70719297
34MP0003868_abnormal_feces_composition1.67052303
35MP0002138_abnormal_hepatobiliary_system1.66803613
36MP0001984_abnormal_olfaction1.60585759
37MP0002876_abnormal_thyroid_physiology1.60187870
38MP0005645_abnormal_hypothalamus_physiol1.56768064
39MP0004043_abnormal_pH_regulation1.54546122
40MP0003191_abnormal_cellular_cholesterol1.52897671
41MP0003718_maternal_effect1.52207809
42MP0004233_abnormal_muscle_weight1.51860607
43MP0004957_abnormal_blastocyst_morpholog1.51556170
44MP0009643_abnormal_urine_homeostasis1.51504542
45MP0004270_analgesia1.47854883
46MP0003077_abnormal_cell_cycle1.46501379
47MP0002272_abnormal_nervous_system1.44038923
48MP0003786_premature_aging1.43737615
49MP0008932_abnormal_embryonic_tissue1.38485988
50MP0006292_abnormal_olfactory_placode1.37508782
51MP0002638_abnormal_pupillary_reflex1.37094143
52MP0004130_abnormal_muscle_cell1.36896381
53MP0001986_abnormal_taste_sensitivity1.33960778
54MP0008789_abnormal_olfactory_epithelium1.33131517
55MP0004859_abnormal_synaptic_plasticity1.32269117
56MP0009745_abnormal_behavioral_response1.31652075
57MP0002064_seizures1.30344730
58MP0001661_extended_life_span1.28164272
59MP0006276_abnormal_autonomic_nervous1.27757915
60MP0005535_abnormal_body_temperature1.25274787
61MP0005636_abnormal_mineral_homeostasis1.23493403
62MP0005330_cardiomyopathy1.23008237
63MP0008877_abnormal_DNA_methylation1.22776025
64MP0002102_abnormal_ear_morphology1.17675745
65MP0003122_maternal_imprinting1.16744472
66MP0002090_abnormal_vision1.16654231
67MP0005647_abnormal_sex_gland1.16466209
68MP0004215_abnormal_myocardial_fiber1.16369596
69MP0005499_abnormal_olfactory_system1.15169271
70MP0005394_taste/olfaction_phenotype1.15169271
71MP0002736_abnormal_nociception_after1.15035295
72MP0002234_abnormal_pharynx_morphology1.14724540
73MP0006072_abnormal_retinal_apoptosis1.13867043
74MP0001968_abnormal_touch/_nociception1.13630205
75MP0002160_abnormal_reproductive_system1.11984033
76MP0000358_abnormal_cell_content/1.11906789
77MP0003011_delayed_dark_adaptation1.10913248
78MP0003635_abnormal_synaptic_transmissio1.10689931
79MP0002938_white_spotting1.10232060
80MP0005551_abnormal_eye_electrophysiolog1.08657083
81MP0002971_abnormal_brown_adipose1.07774302
82MP0006035_abnormal_mitochondrial_morpho1.07479718
83MP0005253_abnormal_eye_physiology1.06715564
84MP0002822_catalepsy1.05090390
85MP0004147_increased_porphyrin_level1.01945115
86MP0004036_abnormal_muscle_relaxation1.00823514
87MP0005376_homeostasis/metabolism_phenot0.96057545
88MP0005266_abnormal_metabolism0.95995280
89MP0002106_abnormal_muscle_physiology0.95984091
90MP0008007_abnormal_cellular_replicative0.95774128
91MP0002572_abnormal_emotion/affect_behav0.94165728
92MP0002078_abnormal_glucose_homeostasis0.93098619
93MP0005423_abnormal_somatic_nervous0.92588435
94MP0000750_abnormal_muscle_regeneration0.89618528
95MP0010030_abnormal_orbit_morphology0.89276056
96MP0005666_abnormal_adipose_tissue0.89182516
97MP0000751_myopathy0.89012432
98MP0002734_abnormal_mechanical_nocicepti0.87286598
99MP0005334_abnormal_fat_pad0.87240036
100MP0008260_abnormal_autophagy0.86264772
101MP0001486_abnormal_startle_reflex0.86178413
102MP0000749_muscle_degeneration0.85908637
103MP0009764_decreased_sensitivity_to0.85739991
104MP0009642_abnormal_blood_homeostasis0.85093088
105MP0003656_abnormal_erythrocyte_physiolo0.83978557
106MP0001756_abnormal_urination0.83842835
107MP0003121_genomic_imprinting0.83342634
108MP0004811_abnormal_neuron_physiology0.81513695
109MP0000598_abnormal_liver_morphology0.79380876
110MP0004924_abnormal_behavior0.79377508
111MP0005386_behavior/neurological_phenoty0.79377508
112MP0000759_abnormal_skeletal_muscle0.78639122
113MP0002063_abnormal_learning/memory/cond0.77594057
114MP0003137_abnormal_impulse_conducting0.76941527
115MP0005084_abnormal_gallbladder_morpholo0.76932198
116MP0009763_increased_sensitivity_to0.76787045
117MP0002557_abnormal_social/conspecific_i0.76064870
118MP0003690_abnormal_glial_cell0.75508605
119MP0000230_abnormal_systemic_arterial0.75452374
120MP0002229_neurodegeneration0.74439987
121MP0003567_abnormal_fetal_cardiomyocyte0.74139069
122MP0008469_abnormal_protein_level0.72990561
123MP0004133_heterotaxia0.71856701
124MP0002733_abnormal_thermal_nociception0.71680365
125MP0002210_abnormal_sex_determination0.69992337
126MP0002972_abnormal_cardiac_muscle0.69751834
127MP0002066_abnormal_motor_capabilities/c0.69347726
128MP0001929_abnormal_gametogenesis0.69054424
129MP0002332_abnormal_exercise_endurance0.69004973
130MP0004084_abnormal_cardiac_muscle0.68330954
131MP0001529_abnormal_vocalization0.67858324
132MP0002269_muscular_atrophy0.67812658
133MP0004142_abnormal_muscle_tone0.67520973
134MP0005620_abnormal_muscle_contractility0.65562538
135MP0005646_abnormal_pituitary_gland0.65053910
136MP0008872_abnormal_physiological_respon0.63639705
137MP0000747_muscle_weakness0.63217687
138MP0002136_abnormal_kidney_physiology0.61536475
139MP0001765_abnormal_ion_homeostasis0.61241763
140MP0005408_hypopigmentation0.61226115
141MP0009765_abnormal_xenobiotic_induced0.58371718
142MP0003953_abnormal_hormone_level0.57529738
143MP0003221_abnormal_cardiomyocyte_apopto0.57178746
144MP0005448_abnormal_energy_balance0.57056834
145MP0008874_decreased_physiological_sensi0.54299348
146MP0003959_abnormal_lean_body0.54241655
147MP0001544_abnormal_cardiovascular_syste0.53716688
148MP0005385_cardiovascular_system_phenoty0.53716688
149MP0000604_amyloidosis0.53596911
150MP0004085_abnormal_heartbeat0.51296991
151MP0010368_abnormal_lymphatic_system0.48320449
152MP0008775_abnormal_heart_ventricle0.47871683
153MP0004145_abnormal_muscle_electrophysio0.46983224
154MP0009115_abnormal_fat_cell0.46047224
155MP0004087_abnormal_muscle_fiber0.43992802
156MP0005452_abnormal_adipose_tissue0.43877358
157MP0000538_abnormal_urinary_bladder0.42519662
158MP0001905_abnormal_dopamine_level0.42240260
159MP0006138_congestive_heart_failure0.39778142
160MP0002254_reproductive_system_inflammat0.37817134
161MP0005058_abnormal_lysosome_morphology0.37792968
162MP0000639_abnormal_adrenal_gland0.37129507
163MP0005595_abnormal_vascular_smooth0.37033909

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.75102370
2Intrahepatic cholestasis (HP:0001406)5.04135144
3Hyperammonemia (HP:0001987)4.61916315
4Prolonged partial thromboplastin time (HP:0003645)4.54264952
5Hypoglycemic coma (HP:0001325)4.47116568
6Hyperglycinuria (HP:0003108)4.39949085
7Hyperglycinemia (HP:0002154)4.38653300
8Ketosis (HP:0001946)4.35437001
9Deep venous thrombosis (HP:0002625)4.31472828
10Hypobetalipoproteinemia (HP:0003563)4.30792621
11Abnormality of serine family amino acid metabolism (HP:0010894)4.30032274
12Abnormality of glycine metabolism (HP:0010895)4.30032274
13Hyperlipoproteinemia (HP:0010980)4.28010563
14Xanthomatosis (HP:0000991)4.27457854
15Abnormality of fatty-acid metabolism (HP:0004359)4.27358301
16Abnormality of monocarboxylic acid metabolism (HP:0010996)4.25515349
17Abnormality of dicarboxylic acid metabolism (HP:0010995)4.13680383
18Dicarboxylic aciduria (HP:0003215)4.13680383
19Cerebral edema (HP:0002181)4.00448315
20Hepatic necrosis (HP:0002605)3.75536168
21Generalized aminoaciduria (HP:0002909)3.69062136
22Ketoacidosis (HP:0001993)3.64873073
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.54731551
24Increased hepatocellular lipid droplets (HP:0006565)3.49740491
25Acute encephalopathy (HP:0006846)3.49360914
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45970901
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.41065095
28Hypolipoproteinemia (HP:0010981)3.39874506
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38990678
30Lethargy (HP:0001254)3.38682479
31Epidermoid cyst (HP:0200040)3.38297563
32Abnormality of serum amino acid levels (HP:0003112)3.31479465
33Joint hemorrhage (HP:0005261)3.28215084
34Metabolic acidosis (HP:0001942)3.26307291
35Abnormality of methionine metabolism (HP:0010901)3.25208886
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.21550581
37Complement deficiency (HP:0004431)3.18900464
38Proximal tubulopathy (HP:0000114)3.18154996
39Hypoalphalipoproteinemia (HP:0003233)3.09998249
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.07426563
41Acute necrotizing encephalopathy (HP:0006965)3.06913332
42Abnormal mitochondria in muscle tissue (HP:0008316)3.04809011
43Renal cortical cysts (HP:0000803)3.03645030
44Hepatocellular necrosis (HP:0001404)3.03254771
45Exercise intolerance (HP:0003546)3.00437543
46Abnormality of the labia minora (HP:0012880)2.96569195
47Delayed CNS myelination (HP:0002188)2.93659599
48Cerebral hypomyelination (HP:0006808)2.89688702
49Glycosuria (HP:0003076)2.86328207
50Abnormality of urine glucose concentration (HP:0011016)2.86328207
51Conjugated hyperbilirubinemia (HP:0002908)2.85076846
52Methylmalonic aciduria (HP:0012120)2.83642589
53Increased CSF lactate (HP:0002490)2.82283875
54Microvesicular hepatic steatosis (HP:0001414)2.80155449
55Increased serum pyruvate (HP:0003542)2.78503478
56Abnormality of glycolysis (HP:0004366)2.78503478
57Abnormality of pyrimidine metabolism (HP:0004353)2.76751602
58Fat malabsorption (HP:0002630)2.76670433
59Mitochondrial inheritance (HP:0001427)2.75341633
60Abnormality of nucleobase metabolism (HP:0010932)2.74692025
61Gout (HP:0001997)2.73895085
62Abnormality of purine metabolism (HP:0004352)2.73662237
63Vomiting (HP:0002013)2.72112530
64Hyperbilirubinemia (HP:0002904)2.71031321
65Lactic acidosis (HP:0003128)2.68459711
66Myoglobinuria (HP:0002913)2.66823764
67Increased muscle lipid content (HP:0009058)2.65752210
68Exercise-induced muscle cramps (HP:0003710)2.65443131
69Renal Fanconi syndrome (HP:0001994)2.56843490
70Myokymia (HP:0002411)2.55301347
71Progressive macrocephaly (HP:0004481)2.54230033
72Abnormality of the common coagulation pathway (HP:0010990)2.43720763
73Abnormality of the intrinsic pathway (HP:0010989)2.43319354
74Multiple enchondromatosis (HP:0005701)2.43115217
75Nausea (HP:0002018)2.40013491
76Increased intramyocellular lipid droplets (HP:0012240)2.39675081
77Leukodystrophy (HP:0002415)2.36854502
78Lipid accumulation in hepatocytes (HP:0006561)2.36353825
79Hypoglycemic seizures (HP:0002173)2.36090761
80CNS hypomyelination (HP:0003429)2.36081596
81Optic disc pallor (HP:0000543)2.34341331
82Enlarged kidneys (HP:0000105)2.34127586
83Hyperventilation (HP:0002883)2.33423349
84Increased serum lactate (HP:0002151)2.30931379
85Methylmalonic acidemia (HP:0002912)2.30728905
86Hypercholesterolemia (HP:0003124)2.29593964
87Rimmed vacuoles (HP:0003805)2.25581722
88Abnormal gallbladder morphology (HP:0012437)2.23596582
89Ragged-red muscle fibers (HP:0003200)2.23335712
90Vascular calcification (HP:0004934)2.21685694
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19828391
92Exercise-induced myalgia (HP:0003738)2.19062231
93Opisthotonus (HP:0002179)2.17030580
94Abnormality of complement system (HP:0005339)2.16276978
95Abnormal gallbladder physiology (HP:0012438)2.15028144
96Cholecystitis (HP:0001082)2.15028144
97Cholelithiasis (HP:0001081)2.14828447
98Spontaneous abortion (HP:0005268)2.14462213
99Hepatocellular carcinoma (HP:0001402)2.13489787
100Increased purine levels (HP:0004368)2.12517607
101Hyperuricemia (HP:0002149)2.12517607
102Emotional lability (HP:0000712)2.09964295
103Progressive muscle weakness (HP:0003323)2.09837038
104Steatorrhea (HP:0002570)2.08329698
1053-Methylglutaconic aciduria (HP:0003535)2.08196187
106Rhabdomyolysis (HP:0003201)2.07403309
107Type I transferrin isoform profile (HP:0003642)2.06565574
108Alkalosis (HP:0001948)2.05605811
109Muscle fiber inclusion bodies (HP:0100299)2.03091415
110CNS demyelination (HP:0007305)2.03027450
111Respiratory difficulties (HP:0002880)2.00500083
112Respiratory failure (HP:0002878)2.00404416
113Hyperinsulinemic hypoglycemia (HP:0000825)1.99900542
114Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96855237
115Skin nodule (HP:0200036)1.96748043
116Irritability (HP:0000737)1.95563171
117Hypokinesia (HP:0002375)1.95145453
118Nemaline bodies (HP:0003798)1.94926654
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89973405
120Abnormality of alanine metabolism (HP:0010916)1.89973405
121Hyperalaninemia (HP:0003348)1.89973405
122Abnormality of vitamin metabolism (HP:0100508)1.89482659
123Neoplasm of the adrenal gland (HP:0100631)1.89427882
124Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89230102
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85293070
126Gliosis (HP:0002171)1.81914147
127Abnormal protein glycosylation (HP:0012346)1.79348313
128Abnormal glycosylation (HP:0012345)1.79348313
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79348313
130Abnormal protein N-linked glycosylation (HP:0012347)1.79348313
131Palpitations (HP:0001962)1.79226927
132Medial flaring of the eyebrow (HP:0010747)1.77926245
133Hypoplastic pelvis (HP:0008839)1.77786683
134Sudden death (HP:0001699)1.77686978
135X-linked dominant inheritance (HP:0001423)1.76746750
136Abnormal number of erythroid precursors (HP:0012131)1.75412490
137Double outlet right ventricle (HP:0001719)1.73521440
138Congenital malformation of the right heart (HP:0011723)1.73521440
139Abnormality of placental membranes (HP:0011409)1.72477783
140Amniotic constriction ring (HP:0009775)1.72477783
141Bundle branch block (HP:0011710)1.71871077
142Chromsome breakage (HP:0040012)1.70361155
143Abnormality of cells of the erythroid lineage (HP:0012130)1.65608275
144Poor eye contact (HP:0000817)1.64866143
145Exertional dyspnea (HP:0002875)1.61759567
146Gait imbalance (HP:0002141)1.60883979
147Delusions (HP:0000746)1.60579463
148Congenital primary aphakia (HP:0007707)1.59776650
149Colon cancer (HP:0003003)1.59621694
150Poor suck (HP:0002033)1.59538497
151Progressive microcephaly (HP:0000253)1.59241501
152EMG: myopathic abnormalities (HP:0003458)1.57672469
153Birth length less than 3rd percentile (HP:0003561)1.57010356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.83393607
2PINK13.23209040
3VRK23.13067812
4INSRR2.82717955
5BUB12.71130224
6MAP4K22.59425871
7MYLK2.39887068
8OBSCN2.32670548
9SRPK12.25105347
10PDK42.24269096
11PDK32.24269096
12MAP2K42.20054508
13OXSR12.16386062
14NEK12.06880798
15BMPR1B2.04233192
16FLT32.03834821
17STK161.99906589
18CASK1.95373256
19TAOK21.84922190
20MAP2K71.83437462
21EPHA41.71019503
22PIM21.70742492
23NUAK11.69596649
24SIK11.68671878
25VRK11.67785611
26CDC71.65231910
27NME21.61563515
28PLK41.58311861
29PRPF4B1.58158106
30TIE11.52670408
31TRIM281.49488996
32MAPK121.47997935
33ADRBK21.45711568
34PDK21.43697684
35PLK31.43533877
36MAP2K31.42389290
37ZAK1.41072515
38WNK41.39930836
39WNK31.38892375
40TTK1.36601629
41CCNB11.36376774
42LIMK11.34373213
43EIF2AK31.33319361
44STK38L1.28441529
45DAPK11.26330464
46TLK11.26203794
47CSNK1G21.24398277
48PLK11.23236363
49GRK71.23219585
50PBK1.22985467
51MAP3K41.18188313
52BRSK11.17152376
53MAPK111.16528828
54PRKAA21.13771571
55PAK61.13606267
56ERBB41.13237745
57CAMK2G1.12917879
58MAPK71.09806096
59FGFR41.07551985
60TYK21.07351980
61PIK3CA1.06106467
62BRAF1.02863567
63AKT31.01279260
64MARK10.98780200
65PLK20.96815969
66MAP3K60.96516345
67CDK190.96453087
68MKNK20.96311247
69TSSK60.95564672
70ATR0.95297776
71DYRK20.94980501
72PHKG10.93041226
73PHKG20.93041226
74TNIK0.92535641
75PRKCG0.89922832
76MAP2K60.89047408
77GRK10.88998202
78SIK30.87615366
79PAK30.87116243
80MINK10.85545498
81NME10.84430704
82PKN10.84419779
83PIK3CG0.83963548
84DAPK20.82199909
85MAP3K120.81822415
86IRAK30.80776599
87GRK60.79414610
88ERBB30.77744937
89AURKB0.76918750
90BCR0.76134784
91AURKA0.74998234
92ABL20.74843108
93SGK2230.74604999
94SGK4940.74604999
95SGK20.72206253
96STK390.71603771
97MKNK10.71566438
98CAMK2A0.71389500
99BMPR20.70917474
100MAPK40.69626538
101CAMK2D0.68869887
102MUSK0.68862836
103CHEK20.66514114
104PRKACG0.60803928
105EIF2AK10.60535512
106MAP3K50.60173066
107MST40.58688670
108MAP3K30.56955768
109CSNK2A10.56797146
110CSNK1G30.56324886
111WEE10.56119586
112PRKAA10.55990437
113TAOK30.55688063
114BLK0.54744943
115MAP3K140.54527689
116CDK140.53777904
117MAPKAPK50.53544007
118DAPK30.53318580
119ALK0.53245700
120CSNK2A20.52324561
121CAMK40.52320467
122BRSK20.52274923
123IRAK20.51598613
124MAP3K70.50752707
125PRKACA0.50637015
126PKN20.48708931
127GRK50.48333683
128CAMK2B0.47959278
129CSNK1G10.47534664
130EIF2AK20.47422121
131CDK11A0.47123824
132CSNK1A10.46440398
133ATM0.46253158
134CSNK1E0.46225687
135TESK10.45703642
136CDK30.45611967
137IRAK10.45115746
138RAF10.44209803
139CDK180.43865266
140PRKCE0.43275497
141CAMK10.42949265
142CDK150.42655763
143RPS6KA50.42318049
144AKT20.41381202
145MST1R0.40679365
146MAP3K110.40297503
147CHEK10.40012358
148PRKACB0.39199290
149CSNK1A1L0.38755079
150PRKCA0.38082962
151MAPKAPK30.37196458
152PRKCQ0.36771489
153ARAF0.36698652
154JAK20.36497650
155TTN0.36048981
156CDK70.35021093
157PRKDC0.34801966
158ERN10.33548457
159PRKCZ0.32051916

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.40981820
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93463159
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.91971109
4Propanoate metabolism_Homo sapiens_hsa006402.84989010
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84205389
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81158211
7Fatty acid degradation_Homo sapiens_hsa000712.74011053
8Butanoate metabolism_Homo sapiens_hsa006502.58362615
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58169780
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54180639
11Tryptophan metabolism_Homo sapiens_hsa003802.49792235
12Nitrogen metabolism_Homo sapiens_hsa009102.46348869
13Arginine biosynthesis_Homo sapiens_hsa002202.45687120
14DNA replication_Homo sapiens_hsa030302.30288205
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26499495
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25597172
17Peroxisome_Homo sapiens_hsa041462.20610585
18RNA polymerase_Homo sapiens_hsa030202.16396868
19Mismatch repair_Homo sapiens_hsa034302.13711502
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12147194
21Fatty acid metabolism_Homo sapiens_hsa012122.11143514
22Ribosome_Homo sapiens_hsa030101.97722405
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93839416
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91617571
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91481408
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90683224
27Fatty acid elongation_Homo sapiens_hsa000621.90041732
28Base excision repair_Homo sapiens_hsa034101.89049908
29Pyruvate metabolism_Homo sapiens_hsa006201.87214352
30beta-Alanine metabolism_Homo sapiens_hsa004101.85567102
31Complement and coagulation cascades_Homo sapiens_hsa046101.84221874
32PPAR signaling pathway_Homo sapiens_hsa033201.72707109
33Histidine metabolism_Homo sapiens_hsa003401.72047211
34Protein export_Homo sapiens_hsa030601.70371761
35Chemical carcinogenesis_Homo sapiens_hsa052041.67577710
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.66840948
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64003193
38Carbon metabolism_Homo sapiens_hsa012001.63212686
39Homologous recombination_Homo sapiens_hsa034401.58687808
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58301563
41Retinol metabolism_Homo sapiens_hsa008301.54249478
42Oxidative phosphorylation_Homo sapiens_hsa001901.53583088
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.52397379
44Phenylalanine metabolism_Homo sapiens_hsa003601.50754541
45Nucleotide excision repair_Homo sapiens_hsa034201.47963698
46Sulfur metabolism_Homo sapiens_hsa009201.44085126
47Non-homologous end-joining_Homo sapiens_hsa034501.40258027
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35626651
49Starch and sucrose metabolism_Homo sapiens_hsa005001.33969867
50Tyrosine metabolism_Homo sapiens_hsa003501.32962923
51Caffeine metabolism_Homo sapiens_hsa002321.32636382
52Basal transcription factors_Homo sapiens_hsa030221.32350259
53Folate biosynthesis_Homo sapiens_hsa007901.29853005
54Spliceosome_Homo sapiens_hsa030401.27161237
55RNA transport_Homo sapiens_hsa030131.23775521
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23742375
57Biosynthesis of amino acids_Homo sapiens_hsa012301.23680546
58Parkinsons disease_Homo sapiens_hsa050121.22716600
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22522533
60Selenocompound metabolism_Homo sapiens_hsa004501.21328171
61Arginine and proline metabolism_Homo sapiens_hsa003301.17074146
62Fanconi anemia pathway_Homo sapiens_hsa034601.15040057
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.14323784
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10630581
65Bile secretion_Homo sapiens_hsa049761.07757582
66Staphylococcus aureus infection_Homo sapiens_hsa051501.06965442
67RNA degradation_Homo sapiens_hsa030181.03840150
68Cyanoamino acid metabolism_Homo sapiens_hsa004601.00960509
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94126101
70ABC transporters_Homo sapiens_hsa020100.92401518
71Steroid biosynthesis_Homo sapiens_hsa001000.92122535
72Synaptic vesicle cycle_Homo sapiens_hsa047210.92086641
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90566696
74Sulfur relay system_Homo sapiens_hsa041220.86056049
75Vitamin digestion and absorption_Homo sapiens_hsa049770.85959906
76Alzheimers disease_Homo sapiens_hsa050100.83990327
77Fat digestion and absorption_Homo sapiens_hsa049750.81112592
78Vitamin B6 metabolism_Homo sapiens_hsa007500.80139056
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76440685
80Nicotine addiction_Homo sapiens_hsa050330.75841142
81* Metabolic pathways_Homo sapiens_hsa011000.75408708
82Glutathione metabolism_Homo sapiens_hsa004800.72744178
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.70541889
84Huntingtons disease_Homo sapiens_hsa050160.68953189
85Glycerolipid metabolism_Homo sapiens_hsa005610.67045010
86Fructose and mannose metabolism_Homo sapiens_hsa000510.63398213
87Cardiac muscle contraction_Homo sapiens_hsa042600.62639898
88Cell cycle_Homo sapiens_hsa041100.60152353
89Oocyte meiosis_Homo sapiens_hsa041140.60028385
90Lysine degradation_Homo sapiens_hsa003100.58633834
91Pentose phosphate pathway_Homo sapiens_hsa000300.55846713
92One carbon pool by folate_Homo sapiens_hsa006700.50330821
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48516708
94Fatty acid biosynthesis_Homo sapiens_hsa000610.48240573
95Vibrio cholerae infection_Homo sapiens_hsa051100.47430918
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41523419
97GABAergic synapse_Homo sapiens_hsa047270.36367830
98Galactose metabolism_Homo sapiens_hsa000520.34407685
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33778955
100mRNA surveillance pathway_Homo sapiens_hsa030150.32787035
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30927564
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29372570
103Linoleic acid metabolism_Homo sapiens_hsa005910.25528839
104Olfactory transduction_Homo sapiens_hsa047400.25356172
105Morphine addiction_Homo sapiens_hsa050320.23853201
106Circadian rhythm_Homo sapiens_hsa047100.18591361
107Dilated cardiomyopathy_Homo sapiens_hsa054140.17928319
108Circadian entrainment_Homo sapiens_hsa047130.17504335
109Regulation of autophagy_Homo sapiens_hsa041400.16974957
110Glucagon signaling pathway_Homo sapiens_hsa049220.14943823
111Collecting duct acid secretion_Homo sapiens_hsa049660.13321861
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.12011527
113Arachidonic acid metabolism_Homo sapiens_hsa005900.11794340
114Proteasome_Homo sapiens_hsa030500.07645679
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.04682818
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03371366
117Ether lipid metabolism_Homo sapiens_hsa00565-0.1703011
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1634997
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1551488
120African trypanosomiasis_Homo sapiens_hsa05143-0.1391009
121Phototransduction_Homo sapiens_hsa04744-0.1266604
122AMPK signaling pathway_Homo sapiens_hsa04152-0.0674724
123Prion diseases_Homo sapiens_hsa05020-0.0645482
124Purine metabolism_Homo sapiens_hsa00230-0.0574453
125Insulin resistance_Homo sapiens_hsa04931-0.0490218
126* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0325585
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0303390
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0245428
129Pyrimidine metabolism_Homo sapiens_hsa00240-0.0111487

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