GATC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.07065157
2polyketide metabolic process (GO:0030638)7.07065157
3doxorubicin metabolic process (GO:0044598)7.07065157
4ribosomal small subunit biogenesis (GO:0042274)5.53572638
5maturation of SSU-rRNA (GO:0030490)5.42632195
6DNA replication checkpoint (GO:0000076)5.13658846
7response to pheromone (GO:0019236)4.80210450
8rRNA modification (GO:0000154)4.43750845
9ribosomal large subunit biogenesis (GO:0042273)4.33333468
10pyrimidine nucleobase catabolic process (GO:0006208)4.24404520
11aminoglycoside antibiotic metabolic process (GO:0030647)4.22242323
12rRNA methylation (GO:0031167)4.16586264
13translational termination (GO:0006415)4.14703024
14viral transcription (GO:0019083)4.10967803
15transcription elongation from RNA polymerase III promoter (GO:0006385)3.99088943
16termination of RNA polymerase III transcription (GO:0006386)3.99088943
17rRNA processing (GO:0006364)3.97292760
18ribonucleoprotein complex biogenesis (GO:0022613)3.91291137
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86968049
20rRNA metabolic process (GO:0016072)3.84971901
21chromatin remodeling at centromere (GO:0031055)3.81434353
22pseudouridine synthesis (GO:0001522)3.79677762
23ribosomal small subunit assembly (GO:0000028)3.79273727
24regulation of nuclear cell cycle DNA replication (GO:0033262)3.75547894
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.73770401
26cotranslational protein targeting to membrane (GO:0006613)3.71887122
27CENP-A containing nucleosome assembly (GO:0034080)3.69523934
28protein targeting to ER (GO:0045047)3.67388891
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.63705582
30folic acid metabolic process (GO:0046655)3.58153035
31translational elongation (GO:0006414)3.57832211
32oxidative demethylation (GO:0070989)3.55498202
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53339735
34cellular component biogenesis (GO:0044085)3.51299452
35nonmotile primary cilium assembly (GO:0035058)3.49478758
36translational initiation (GO:0006413)3.49165347
37maturation of 5.8S rRNA (GO:0000460)3.47060294
38ribosome assembly (GO:0042255)3.44300930
39folic acid-containing compound biosynthetic process (GO:0009396)3.44039840
40viral mRNA export from host cell nucleus (GO:0046784)3.43900107
41negative regulation of transcription regulatory region DNA binding (GO:2000678)3.42992816
42kinetochore organization (GO:0051383)3.42605148
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42381708
44protein localization to endoplasmic reticulum (GO:0070972)3.41121697
45* translation (GO:0006412)3.40857994
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39842159
47DNA demethylation (GO:0080111)3.39710873
48nucleobase biosynthetic process (GO:0046112)3.38387421
49purine nucleobase biosynthetic process (GO:0009113)3.36818058
50mitochondrial respiratory chain complex assembly (GO:0033108)3.36011060
51mitotic sister chromatid segregation (GO:0000070)3.35893033
52DNA replication initiation (GO:0006270)3.28230360
53ribosome biogenesis (GO:0042254)3.27966650
54meiotic chromosome segregation (GO:0045132)3.27300496
55spliceosomal snRNP assembly (GO:0000387)3.25380248
56regulation of translational termination (GO:0006449)3.24447435
57regulation of mitochondrial translation (GO:0070129)3.23970273
58viral life cycle (GO:0019058)3.23134454
59nuclear pore organization (GO:0006999)3.22353708
60mitochondrial RNA metabolic process (GO:0000959)3.20549844
61nuclear pore complex assembly (GO:0051292)3.20293988
62chaperone-mediated protein transport (GO:0072321)3.19900419
63cellular protein complex disassembly (GO:0043624)3.19599606
64DNA strand renaturation (GO:0000733)3.17920319
65Golgi transport vesicle coating (GO:0048200)3.17084750
66COPI coating of Golgi vesicle (GO:0048205)3.17084750
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.15444466
68NADH dehydrogenase complex assembly (GO:0010257)3.15444466
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15444466
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14412992
71ATP synthesis coupled proton transport (GO:0015986)3.14412992
72formation of translation preinitiation complex (GO:0001731)3.14278954
73ncRNA processing (GO:0034470)3.14154046
74mitotic metaphase plate congression (GO:0007080)3.13533142
75termination of RNA polymerase II transcription (GO:0006369)3.12471257
76sister chromatid segregation (GO:0000819)3.12294658
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11731676
78deoxyribose phosphate biosynthetic process (GO:0046385)3.11483146
792-deoxyribonucleotide biosynthetic process (GO:0009265)3.11483146
80protein targeting to mitochondrion (GO:0006626)3.09119192
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.08306449
82DNA-templated transcription, termination (GO:0006353)3.07924979
83cerebral cortex radially oriented cell migration (GO:0021799)3.07085044
84mitotic nuclear envelope disassembly (GO:0007077)3.06231466
85somite development (GO:0061053)3.05850143
86regulation of mitotic spindle checkpoint (GO:1903504)3.05357825
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05357825
88regulation of oxidative phosphorylation (GO:0002082)3.04447776
89replication fork processing (GO:0031297)3.04150104
90regulation of centriole replication (GO:0046599)3.01423150
91DNA replication-dependent nucleosome organization (GO:0034723)3.00642937
92DNA replication-dependent nucleosome assembly (GO:0006335)3.00642937
93peptidyl-histidine modification (GO:0018202)2.99838074
94histone exchange (GO:0043486)2.97070920
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96493148
96protoporphyrinogen IX metabolic process (GO:0046501)2.96281159
97* ncRNA metabolic process (GO:0034660)2.95148002
98translesion synthesis (GO:0019985)2.94872935
99protein localization to kinetochore (GO:0034501)2.94387505
100DNA replication-independent nucleosome assembly (GO:0006336)2.93897348
101DNA replication-independent nucleosome organization (GO:0034724)2.93897348
102protein localization to chromosome, centromeric region (GO:0071459)2.93363544
103lysine catabolic process (GO:0006554)2.93223080
104lysine metabolic process (GO:0006553)2.93223080
105establishment of protein localization to mitochondrion (GO:0072655)2.93094821
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.92826621
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91053938
108olfactory bulb development (GO:0021772)2.90991021
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90856879
110nuclear-transcribed mRNA catabolic process (GO:0000956)2.90464390
111mitotic sister chromatid cohesion (GO:0007064)2.90350680
112lactate metabolic process (GO:0006089)2.89974117
113venous blood vessel morphogenesis (GO:0048845)2.85356097
114nucleobase catabolic process (GO:0046113)2.82858363
115DNA deamination (GO:0045006)2.82259871
116receptor recycling (GO:0001881)2.81955976
117GMP metabolic process (GO:0046037)2.81038250
118deoxyribonucleotide biosynthetic process (GO:0009263)2.79333759
119cell proliferation in forebrain (GO:0021846)2.78166339
120response to misfolded protein (GO:0051788)2.78133728
121negative regulation of axon extension involved in axon guidance (GO:0048843)2.77805944
122urinary tract smooth muscle contraction (GO:0014848)2.77088584
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74019864
124neurotransmitter-gated ion channel clustering (GO:0072578)2.73706998
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.73164419
126respiratory chain complex IV assembly (GO:0008535)2.72914416
127telomere maintenance via semi-conservative replication (GO:0032201)2.71557489
128dentate gyrus development (GO:0021542)2.71478108
129DNA strand elongation involved in DNA replication (GO:0006271)2.70459772
130negative regulation of axon guidance (GO:1902668)2.64203163
131NADH metabolic process (GO:0006734)2.62867168
132DNA unwinding involved in DNA replication (GO:0006268)2.60037570
133protein-DNA complex disassembly (GO:0032986)2.59968629
134nucleosome disassembly (GO:0006337)2.59968629
135negative regulation of RNA splicing (GO:0033119)2.58358351
136regulation of glucokinase activity (GO:0033131)2.56126160
137regulation of hexokinase activity (GO:1903299)2.56126160
138protoporphyrinogen IX biosynthetic process (GO:0006782)2.55965629
139postreplication repair (GO:0006301)2.54246448
140mitotic recombination (GO:0006312)2.52379709
141DNA strand elongation (GO:0022616)2.52218283
142G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.52146999
143purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.51657496
1443-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.51657496
145misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.51225963
146proteasome assembly (GO:0043248)2.49017768
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48210650
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48210650
149negative regulation of dendrite development (GO:2000171)2.47800987
150regulation of DNA endoreduplication (GO:0032875)2.46499179
151inner ear receptor stereocilium organization (GO:0060122)2.46374080
152pigment granule localization (GO:0051875)2.46219721
153facial nerve structural organization (GO:0021612)2.45966824
154DNA dealkylation (GO:0035510)2.45503540
155sulfation (GO:0051923)2.44926925
156lateral ventricle development (GO:0021670)2.44256170
157striatum development (GO:0021756)2.42605019
158methionine metabolic process (GO:0006555)2.41872784
159snRNA transcription (GO:0009301)2.41658303
160peptidyl-arginine omega-N-methylation (GO:0035247)2.41272612
161purine-containing compound salvage (GO:0043101)2.39855394
162tetrapyrrole biosynthetic process (GO:0033014)2.39795248
163positive regulation of DNA-dependent DNA replication (GO:2000105)2.38434656
164negative regulation of mRNA processing (GO:0050686)2.37651969
165negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.37274163
166peptidyl-arginine N-methylation (GO:0035246)2.37012574
167peptidyl-arginine methylation (GO:0018216)2.37012574
168regulation of chromatin binding (GO:0035561)2.36966346
169cytochrome complex assembly (GO:0017004)2.35579510
170tricarboxylic acid cycle (GO:0006099)2.35317558
171histone arginine methylation (GO:0034969)2.34119784
172water-soluble vitamin biosynthetic process (GO:0042364)2.33738351
173oxidative phosphorylation (GO:0006119)2.32114597
174methionine biosynthetic process (GO:0009086)2.31754408
175cellular ketone body metabolic process (GO:0046950)2.31368601
176histone H2A acetylation (GO:0043968)2.30277999
177telomere maintenance via recombination (GO:0000722)2.29314978
178IMP biosynthetic process (GO:0006188)2.29295977
179protein complex biogenesis (GO:0070271)2.29219050
180histone deubiquitination (GO:0016578)2.28644523
181exocrine pancreas development (GO:0031017)2.26982819
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.26825249
183sympathetic nervous system development (GO:0048485)2.25632250
184pigment granule transport (GO:0051904)2.25038265
185central nervous system projection neuron axonogenesis (GO:0021952)2.23791344
186kinetochore assembly (GO:0051382)2.23483525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.00948939
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.65383232
3EZH2_22144423_ChIP-Seq_EOC_Human4.14986781
4E2F7_22180533_ChIP-Seq_HELA_Human3.90251285
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.66937540
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40884141
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00616791
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90047103
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76568013
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70155065
11GBX2_23144817_ChIP-Seq_PC3_Human2.63958451
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62160934
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.48508563
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44155115
15* TTF2_22483619_ChIP-Seq_HELA_Human2.43285701
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40227100
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34540479
18ELK1_19687146_ChIP-ChIP_HELA_Human2.28691161
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26727736
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25113576
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.20750344
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16160581
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06547470
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.04748548
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03592649
26KDM5A_27292631_Chip-Seq_BREAST_Human2.01044690
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98331462
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94255773
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.93099294
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91781862
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90282477
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.89456736
33CIITA_25753668_ChIP-Seq_RAJI_Human1.84053470
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83151199
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77983013
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76352666
37AR_21909140_ChIP-Seq_LNCAP_Human1.71503671
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69151924
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.65631177
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64644321
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63418716
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.63015880
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60439458
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.58732850
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58089056
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56879114
47TAF15_26573619_Chip-Seq_HEK293_Human1.56441945
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55944621
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50729067
50GABP_19822575_ChIP-Seq_HepG2_Human1.48476433
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.42538764
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40073547
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.38529619
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36548045
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.35082623
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32239626
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30972234
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29941092
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29192960
60FOXP3_21729870_ChIP-Seq_TREG_Human1.28492717
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28479944
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26920766
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25982327
64VDR_23849224_ChIP-Seq_CD4+_Human1.25250772
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24900494
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23987869
67REST_21632747_ChIP-Seq_MESCs_Mouse1.23714894
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23543172
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23451626
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22051906
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19314630
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18014861
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12927590
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.12363176
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12177478
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10338775
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09861784
78P300_19829295_ChIP-Seq_ESCs_Human1.09380781
79* XRN2_22483619_ChIP-Seq_HELA_Human1.08656704
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07987849
81SOX9_26525672_Chip-Seq_HEART_Mouse1.07170959
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07124067
83FUS_26573619_Chip-Seq_HEK293_Human1.06663478
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06647529
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06640258
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06296318
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06006530
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.05606556
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05333519
90IGF1R_20145208_ChIP-Seq_DFB_Human1.05269987
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04021872
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03829530
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.03744813
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03664918
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03436947
96CHD1_26751641_Chip-Seq_LNCaP_Human1.01089827
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00943212
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00643334
99TFEB_21752829_ChIP-Seq_HELA_Human1.00604892
100* DCP1A_22483619_ChIP-Seq_HELA_Human0.99612329
101EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99209378
102RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99209378
103GABP_17652178_ChIP-ChIP_JURKAT_Human0.98884649
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97421256
105REST_18959480_ChIP-ChIP_MESCs_Mouse0.97117891
106SCL_19346495_ChIP-Seq_HPC-7_Human0.96613528
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96466069
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96001803
109* NOTCH1_21737748_ChIP-Seq_TLL_Human0.95302183
110EWS_26573619_Chip-Seq_HEK293_Human0.95063072
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94554708
112NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94079865
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93715939
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93040686
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92949997
116RARB_27405468_Chip-Seq_BRAIN_Mouse0.92368665
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92174909
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91653649
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91466080
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91285460
121* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91031240
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88919524
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88875824
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87148515
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.86992430
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86667361
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86604498
128MYC_18940864_ChIP-ChIP_HL60_Human0.86404280
129NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85929325
130HTT_18923047_ChIP-ChIP_STHdh_Human0.85743769
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85054160
132ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84442033
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84080050
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82849422
135* FOXP1_21924763_ChIP-Seq_HESCs_Human0.79769129
136ZNF274_21170338_ChIP-Seq_K562_Hela0.75376539
137ELF5_23300383_ChIP-Seq_T47D_Human0.74788065
138MYC_22102868_ChIP-Seq_BL_Human0.74604844
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.74282337
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73755809
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73569905
142ZNF263_19887448_ChIP-Seq_K562_Human0.73536993
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.72584901
144PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72577462
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72034708
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69073847
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68415013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.35034579
2MP0003111_abnormal_nucleus_morphology4.25168282
3MP0008789_abnormal_olfactory_epithelium3.94255507
4MP0004957_abnormal_blastocyst_morpholog3.77228070
5MP0000566_synostosis3.74450147
6MP0006292_abnormal_olfactory_placode3.52015901
7MP0003077_abnormal_cell_cycle3.36301065
8MP0010030_abnormal_orbit_morphology3.31941726
9MP0005394_taste/olfaction_phenotype3.18505690
10MP0005499_abnormal_olfactory_system3.18505690
11MP0005645_abnormal_hypothalamus_physiol2.92253157
12MP0005646_abnormal_pituitary_gland2.83883163
13MP0009379_abnormal_foot_pigmentation2.69583684
14MP0001188_hyperpigmentation2.38011891
15MP0001984_abnormal_olfaction2.37316915
16MP0005365_abnormal_bile_salt2.26842742
17MP0003786_premature_aging2.06099225
18MP0003183_abnormal_peptide_metabolism1.93545274
19MP0003315_abnormal_perineum_morphology1.90048669
20MP0003806_abnormal_nucleotide_metabolis1.86683280
21MP0002160_abnormal_reproductive_system1.82938026
22MP0000049_abnormal_middle_ear1.82385542
23MP0009697_abnormal_copulation1.80750939
24MP0003718_maternal_effect1.77064809
25MP0000350_abnormal_cell_proliferation1.75477614
26MP0010307_abnormal_tumor_latency1.65403072
27MP0005187_abnormal_penis_morphology1.61636800
28MP0002249_abnormal_larynx_morphology1.60868734
29MP0002139_abnormal_hepatobiliary_system1.58264831
30MP0000678_abnormal_parathyroid_gland1.55408747
31MP0004147_increased_porphyrin_level1.54025386
32MP0002938_white_spotting1.52745714
33MP0005085_abnormal_gallbladder_physiolo1.50703940
34MP0004215_abnormal_myocardial_fiber1.47707638
35MP0004859_abnormal_synaptic_plasticity1.43487274
36MP0003656_abnormal_erythrocyte_physiolo1.42569331
37MP0002396_abnormal_hematopoietic_system1.41953400
38MP0005248_abnormal_Harderian_gland1.41457880
39MP0000631_abnormal_neuroendocrine_gland1.39805821
40MP0002877_abnormal_melanocyte_morpholog1.38788188
41MP0001346_abnormal_lacrimal_gland1.38450368
42MP0005423_abnormal_somatic_nervous1.38173640
43MP0001697_abnormal_embryo_size1.37461701
44MP0005551_abnormal_eye_electrophysiolog1.37408245
45MP0002009_preneoplasia1.37273703
46MP0002102_abnormal_ear_morphology1.36932081
47MP0005380_embryogenesis_phenotype1.36900772
48MP0001672_abnormal_embryogenesis/_devel1.36900772
49MP0006276_abnormal_autonomic_nervous1.33720851
50MP0003937_abnormal_limbs/digits/tail_de1.31983959
51MP0008058_abnormal_DNA_repair1.31711898
52MP0001730_embryonic_growth_arrest1.31303217
53MP0005174_abnormal_tail_pigmentation1.30002613
54MP0008007_abnormal_cellular_replicative1.29484466
55MP0009053_abnormal_anal_canal1.27423079
56MP0003122_maternal_imprinting1.24713918
57MP0003984_embryonic_growth_retardation1.24491544
58MP0000313_abnormal_cell_death1.22377699
59MP0002088_abnormal_embryonic_growth/wei1.21934967
60MP0006036_abnormal_mitochondrial_physio1.19980149
61MP0002184_abnormal_innervation1.17882437
62MP0002751_abnormal_autonomic_nervous1.17531701
63MP0003385_abnormal_body_wall1.17315957
64MP0003567_abnormal_fetal_cardiomyocyte1.16645831
65MP0001919_abnormal_reproductive_system1.16511946
66MP0002557_abnormal_social/conspecific_i1.16129592
67MP0002736_abnormal_nociception_after1.15846306
68MP0005220_abnormal_exocrine_pancreas1.14454829
69MP0001529_abnormal_vocalization1.14145126
70MP0005389_reproductive_system_phenotype1.13884214
71MP0003646_muscle_fatigue1.13300197
72MP0002210_abnormal_sex_determination1.13229044
73MP0003136_yellow_coat_color1.12483991
74MP0000749_muscle_degeneration1.10971727
75MP0002080_prenatal_lethality1.10291334
76MP0000358_abnormal_cell_content/1.10235085
77MP0003879_abnormal_hair_cell1.07660598
78MP0001661_extended_life_span1.06439072
79MP0002085_abnormal_embryonic_tissue1.06417546
80MP0002084_abnormal_developmental_patter1.06247734
81MP0002233_abnormal_nose_morphology1.04806627
82MP0001293_anophthalmia0.99820944
83MP0001286_abnormal_eye_development0.99391684
84MP0000537_abnormal_urethra_morphology0.98844813
85MP0003011_delayed_dark_adaptation0.98012877
86MP0002089_abnormal_postnatal_growth/wei0.97703448
87MP0002019_abnormal_tumor_incidence0.97640923
88MP0004197_abnormal_fetal_growth/weight/0.97460362
89MP0001324_abnormal_eye_pigmentation0.97157398
90MP0006072_abnormal_retinal_apoptosis0.96410231
91MP0002163_abnormal_gland_morphology0.96195431
92MP0005409_darkened_coat_color0.96184421
93MP0003693_abnormal_embryo_hatching0.95564347
94MP0003787_abnormal_imprinting0.94774250
95MP0005083_abnormal_biliary_tract0.94552956
96MP0000778_abnormal_nervous_system0.94457975
97MP0001145_abnormal_male_reproductive0.93838513
98MP0003941_abnormal_skin_development0.93815115
99MP0002234_abnormal_pharynx_morphology0.93368874
100MP0002697_abnormal_eye_size0.92558388
101MP0003635_abnormal_synaptic_transmissio0.90840326
102MP0002063_abnormal_learning/memory/cond0.90838118
103MP0002067_abnormal_sensory_capabilities0.90761633
104MP0003123_paternal_imprinting0.90572350
105MP0005377_hearing/vestibular/ear_phenot0.90445950
106MP0003878_abnormal_ear_physiology0.90445950
107MP0003880_abnormal_central_pattern0.89974246
108MP0001485_abnormal_pinna_reflex0.89485717
109MP0008775_abnormal_heart_ventricle0.89407718
110MP0002837_dystrophic_cardiac_calcinosis0.89218186
111MP0000647_abnormal_sebaceous_gland0.89115121
112MP0003938_abnormal_ear_development0.88731821
113MP0009250_abnormal_appendicular_skeleto0.88315462
114MP0001986_abnormal_taste_sensitivity0.86325816
115MP0001873_stomach_inflammation0.86056127
116MP0004185_abnormal_adipocyte_glucose0.85481331
117MP0009672_abnormal_birth_weight0.85329382
118MP0002086_abnormal_extraembryonic_tissu0.85036782
119MP0005501_abnormal_skin_physiology0.84447092
120MP0000516_abnormal_urinary_system0.83971627
121MP0005367_renal/urinary_system_phenotyp0.83971627
122MP0000653_abnormal_sex_gland0.83668751
123MP0009780_abnormal_chondrocyte_physiolo0.83448781
124MP0002116_abnormal_craniofacial_bone0.82803426
125MP0003868_abnormal_feces_composition0.82732489
126MP0002277_abnormal_respiratory_mucosa0.82721594
127MP0002734_abnormal_mechanical_nocicepti0.82584739
128MP0010094_abnormal_chromosome_stability0.82101005
129MP0004085_abnormal_heartbeat0.82063219
130MP0003137_abnormal_impulse_conducting0.80912326
131MP0000026_abnormal_inner_ear0.80839988
132MP0001968_abnormal_touch/_nociception0.80555947
133MP0005171_absent_coat_pigmentation0.80225319
134MP0001944_abnormal_pancreas_morphology0.79811111
135MP0006035_abnormal_mitochondrial_morpho0.79121939
136MP0001929_abnormal_gametogenesis0.78409606
137MP0000427_abnormal_hair_cycle0.77416726
138MP0003943_abnormal_hepatobiliary_system0.77399132
139MP0001186_pigmentation_phenotype0.77267541
140MP0003115_abnormal_respiratory_system0.76843381
141MP0010352_gastrointestinal_tract_polyps0.76527470
142MP0003195_calcinosis0.76470648
143MP0003186_abnormal_redox_activity0.75669008
144MP0004043_abnormal_pH_regulation0.75179815
145MP0003121_genomic_imprinting0.75138225
146MP0003942_abnormal_urinary_system0.74746966
147MP0001486_abnormal_startle_reflex0.73992376
148MP0008004_abnormal_stomach_pH0.73688739
149MP0002111_abnormal_tail_morphology0.72662751
150MP0002272_abnormal_nervous_system0.71509832
151MP0000490_abnormal_crypts_of0.71058346
152MP0000538_abnormal_urinary_bladder0.71021062
153MP0008961_abnormal_basal_metabolism0.70999861
154MP0005379_endocrine/exocrine_gland_phen0.70907510
155MP0008995_early_reproductive_senescence0.70020033
156MP0004145_abnormal_muscle_electrophysio0.69889615
157MP0002638_abnormal_pupillary_reflex0.68875970
158MP0010329_abnormal_lipoprotein_level0.68681422
159MP0001764_abnormal_homeostasis0.68511121
160MP0000681_abnormal_thyroid_gland0.68275454
161MP0003890_abnormal_embryonic-extraembry0.68261012
162MP0002932_abnormal_joint_morphology0.67946863
163MP0001881_abnormal_mammary_gland0.67254314
164MP0005332_abnormal_amino_acid0.67246401
165MP0002572_abnormal_emotion/affect_behav0.66963431
166MP0004134_abnormal_chest_morphology0.66325518
167MP0002269_muscular_atrophy0.65428719
168MP0008873_increased_physiological_sensi0.65054677
169MP0009703_decreased_birth_body0.64907593
170MP0008932_abnormal_embryonic_tissue0.63846114
171MP0004233_abnormal_muscle_weight0.63241783
172MP0003119_abnormal_digestive_system0.62842643

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.38512225
2Birth length less than 3rd percentile (HP:0003561)3.91486027
3Abnormal number of erythroid precursors (HP:0012131)3.87139933
4Abnormality of cells of the erythroid lineage (HP:0012130)3.84177255
5True hermaphroditism (HP:0010459)3.77083210
6Chromsome breakage (HP:0040012)3.69392772
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61950139
8Reticulocytopenia (HP:0001896)3.55469892
9Pancreatic fibrosis (HP:0100732)3.54262212
10Abnormality of the metopic suture (HP:0005556)3.27943485
11Increased hepatocellular lipid droplets (HP:0006565)3.27193769
12Abnormality of alanine metabolism (HP:0010916)3.24279163
13Hyperalaninemia (HP:0003348)3.24279163
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24279163
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.21636942
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.16639535
17Acute necrotizing encephalopathy (HP:0006965)3.16150161
18Lipid accumulation in hepatocytes (HP:0006561)3.12158628
19Macrocytic anemia (HP:0001972)3.09729071
20Opisthotonus (HP:0002179)3.06028300
21Absent thumb (HP:0009777)2.94742042
22Acute encephalopathy (HP:0006846)2.83925876
23Abnormality of the intervertebral disk (HP:0005108)2.82222715
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79549782
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79549782
26Abnormality of methionine metabolism (HP:0010901)2.78493793
27Meckel diverticulum (HP:0002245)2.77849258
28Abnormality of chromosome stability (HP:0003220)2.77216051
29Abnormality of the aortic arch (HP:0012303)2.75885172
30Occipital encephalocele (HP:0002085)2.74941637
31Abnormality of the ileum (HP:0001549)2.72423468
32Ketoacidosis (HP:0001993)2.70590441
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.69053624
34Rectal fistula (HP:0100590)2.68260437
35Rectovaginal fistula (HP:0000143)2.68260437
36Nephrogenic diabetes insipidus (HP:0009806)2.66392517
37Generalized aminoaciduria (HP:0002909)2.65825533
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65729815
39Absent radius (HP:0003974)2.63766994
40Aplastic anemia (HP:0001915)2.62345931
41Pendular nystagmus (HP:0012043)2.58488948
42Septate vagina (HP:0001153)2.56941079
433-Methylglutaconic aciduria (HP:0003535)2.55179320
44Progressive macrocephaly (HP:0004481)2.55060743
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.53571274
46Absent forearm bone (HP:0003953)2.51877004
47Aplasia involving forearm bones (HP:0009822)2.51877004
48Central scotoma (HP:0000603)2.51204335
49Abnormality of the preputium (HP:0100587)2.46399700
50Ketosis (HP:0001946)2.46159061
51Hyperventilation (HP:0002883)2.42993963
52Cerebral palsy (HP:0100021)2.42176842
53Severe visual impairment (HP:0001141)2.41875467
54Hypoplasia of the pons (HP:0012110)2.41781358
55Methylmalonic acidemia (HP:0002912)2.39406071
56Megaloblastic anemia (HP:0001889)2.37567823
57Chronic hepatic failure (HP:0100626)2.37180764
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.36895797
59Colon cancer (HP:0003003)2.36755885
60Abnormality of the pons (HP:0007361)2.36108613
61Methylmalonic aciduria (HP:0012120)2.34132164
62Short thumb (HP:0009778)2.32653156
63Increased intramyocellular lipid droplets (HP:0012240)2.31634584
64Myelodysplasia (HP:0002863)2.30118024
65Volvulus (HP:0002580)2.29839151
66Intestinal fistula (HP:0100819)2.29536458
67Renal Fanconi syndrome (HP:0001994)2.28870122
68Pallor (HP:0000980)2.27726342
69Gait imbalance (HP:0002141)2.27337158
70Testicular atrophy (HP:0000029)2.24359257
71Hepatic necrosis (HP:0002605)2.24217687
72Congenital stationary night blindness (HP:0007642)2.23701130
73Abnormality of lateral ventricle (HP:0030047)2.23387354
74Pancreatic cysts (HP:0001737)2.20302988
75Progressive muscle weakness (HP:0003323)2.20210008
76Abnormality of the carotid arteries (HP:0005344)2.18612520
77Abnormal rod and cone electroretinograms (HP:0008323)2.17759875
78Congenital primary aphakia (HP:0007707)2.17324753
79Cerebral edema (HP:0002181)2.17074443
80Triphalangeal thumb (HP:0001199)2.17040655
81Microvesicular hepatic steatosis (HP:0001414)2.15364110
82Lissencephaly (HP:0001339)2.14874672
83Poikilocytosis (HP:0004447)2.13515193
84Breast hypoplasia (HP:0003187)2.12860368
85Abnormality of the labia minora (HP:0012880)2.11215771
86Vaginal fistula (HP:0004320)2.08547372
87Bony spicule pigmentary retinopathy (HP:0007737)2.08302998
88Cleft eyelid (HP:0000625)2.06159331
89Hepatocellular necrosis (HP:0001404)2.05230253
90Abnormal number of incisors (HP:0011064)2.05152696
91Type I transferrin isoform profile (HP:0003642)2.04972826
92Epileptiform EEG discharges (HP:0011182)2.04769889
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04023584
94Hyperinsulinemic hypoglycemia (HP:0000825)2.03276249
95Acanthocytosis (HP:0001927)2.02093219
96EEG with generalized epileptiform discharges (HP:0011198)2.00828724
97Respiratory difficulties (HP:0002880)2.00454325
98Lactic acidosis (HP:0003128)2.00201130
99Self-mutilation (HP:0000742)1.99982556
100Hypoplasia of the radius (HP:0002984)1.99929009
101Renal duplication (HP:0000075)1.99723498
102Squamous cell carcinoma (HP:0002860)1.99035001
103Rib fusion (HP:0000902)1.98265894
104Abnormality of serum amino acid levels (HP:0003112)1.96041212
105Optic nerve coloboma (HP:0000588)1.95829627
106Hyperbilirubinemia (HP:0002904)1.95045331
107Preaxial hand polydactyly (HP:0001177)1.94978503
108Wide cranial sutures (HP:0010537)1.94901118
109Hypoglycemic coma (HP:0001325)1.94304072
110Increased serum lactate (HP:0002151)1.94178334
111Increased muscle lipid content (HP:0009058)1.93978883
112Progressive external ophthalmoplegia (HP:0000590)1.93962219
113Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93635901
114Acute lymphatic leukemia (HP:0006721)1.92019364
115Renal cortical cysts (HP:0000803)1.91498859
116Sensory axonal neuropathy (HP:0003390)1.90990064
117Neoplasm of the adrenal gland (HP:0100631)1.90605821
118Duplicated collecting system (HP:0000081)1.90360139
119Anencephaly (HP:0002323)1.90218092
120Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89501646
121Microretrognathia (HP:0000308)1.89471638
122Flared iliac wings (HP:0002869)1.89306140
123Postaxial foot polydactyly (HP:0001830)1.89063603
124Abnormal hair whorl (HP:0010721)1.88440882
125Metabolic acidosis (HP:0001942)1.88367264
126Medial flaring of the eyebrow (HP:0010747)1.87956662
127Hypsarrhythmia (HP:0002521)1.87142777
128Ectopic kidney (HP:0000086)1.86729564
129Poor coordination (HP:0002370)1.86470600
130Aplasia/Hypoplasia of the patella (HP:0006498)1.86416133
131Exercise intolerance (HP:0003546)1.84846374
132Pancytopenia (HP:0001876)1.84536032
133Homocystinuria (HP:0002156)1.83795825
134Abnormality of homocysteine metabolism (HP:0010919)1.83795825
135Hyperglycinemia (HP:0002154)1.83490638
136Hypothermia (HP:0002045)1.82658624
137Hydroureter (HP:0000072)1.82566608
138Leukodystrophy (HP:0002415)1.82534875
139Clubbing of toes (HP:0100760)1.82267625
140Increased CSF lactate (HP:0002490)1.82227440
141Cystic liver disease (HP:0006706)1.81150870
142Protruding tongue (HP:0010808)1.80248569
143Patellar aplasia (HP:0006443)1.80136593
144Febrile seizures (HP:0002373)1.79326288
145Multiple enchondromatosis (HP:0005701)1.78984767
146Scotoma (HP:0000575)1.78145402
147Sloping forehead (HP:0000340)1.76223256
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76121186
149Conjugated hyperbilirubinemia (HP:0002908)1.75760644
150Prominent metopic ridge (HP:0005487)1.74488600
151Esophageal atresia (HP:0002032)1.73915212
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73748993
153Abnormal protein N-linked glycosylation (HP:0012347)1.73748993
154Abnormal protein glycosylation (HP:0012346)1.73748993
155Abnormal glycosylation (HP:0012345)1.73748993
156Long clavicles (HP:0000890)1.73730622
157Elfin facies (HP:0004428)1.73378487
158Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72348065
159Exertional dyspnea (HP:0002875)1.72346345
160Unsteady gait (HP:0002317)1.72158407
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.71806648
162Dandy-Walker malformation (HP:0001305)1.70017438
163Mitral stenosis (HP:0001718)1.69977716
164Renal dysplasia (HP:0000110)1.69008177
165Neoplasm of the liver (HP:0002896)1.68453096
166Facial hemangioma (HP:0000329)1.67923914
167Hyperglycemia (HP:0003074)1.67734760
168Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67047299
169Dicarboxylic aciduria (HP:0003215)1.67047299
170Hypoglycemic seizures (HP:0002173)1.67032308
171Broad toe (HP:0001837)1.65968480
172Abolished electroretinogram (ERG) (HP:0000550)1.65356839
173Abnormality of the anterior horn cell (HP:0006802)1.64721955
174Degeneration of anterior horn cells (HP:0002398)1.64721955
175Mitochondrial inheritance (HP:0001427)1.63040072
176Insomnia (HP:0100785)1.62795780
177Abnormal mitochondria in muscle tissue (HP:0008316)1.62505547
178Abnormality of the phalanges of the hallux (HP:0010057)1.61896170
179Hyperacusis (HP:0010780)1.58302048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.45506723
2NEK13.87590977
3EIF2AK13.55317124
4TLK13.44427474
5CCNB12.54976925
6ERBB32.49309542
7PRPF4B2.42851527
8VRK22.36822546
9NME22.31935250
10CASK2.30297466
11SIK22.24631174
12WEE12.18429781
13SRPK12.15980687
14PNCK2.09106913
15MAP2K72.05768683
16TTK2.03223238
17MARK12.02436274
18PBK1.91215410
19TRIM281.83645273
20VRK11.80891587
21TNIK1.75777750
22CDC71.75644205
23BMPR1B1.71791234
24SGK21.62584002
25CDK81.61361741
26MAPK131.60325512
27BRSK21.58101463
28BCKDK1.57180004
29SIK11.47970307
30PDK21.47171752
31STK161.46925011
32TAF11.46758760
33NEK91.45258044
34BRD41.39237832
35YES11.38979041
36STK241.37592089
37RIPK11.36999315
38TAOK21.34246789
39MINK11.33458408
40INSRR1.31437185
41MST41.30095590
42NUAK11.28833114
43PLK31.27020253
44DAPK21.25679492
45NEK21.25203787
46FRK1.24486186
47PINK11.24392934
48RPS6KB21.24199167
49DAPK11.18821746
50PLK41.14581070
51ZAK1.12384975
52BLK1.10855832
53EEF2K1.10662831
54PLK21.10390150
55MKNK11.09128541
56MAP2K41.09126996
57AURKB1.09060195
58MAP3K121.05926660
59MAPK151.05593492
60ATR1.03736335
61SGK31.01368045
62MKNK21.01111103
63NTRK31.00330076
64DYRK20.99231909
65PASK0.99132949
66WNK40.98931236
67BUB10.96372469
68PHKG10.96122653
69PHKG20.96122653
70SGK4940.92509965
71SGK2230.92509965
72KSR10.92302252
73CDK30.92272933
74CHEK10.91986267
75BRSK10.91143624
76RPS6KA40.90272619
77STK30.86308115
78MAPKAPK30.84959330
79TGFBR20.83303208
80CSNK1G30.82405930
81CSNK1G10.82075981
82MAP3K40.80122630
83CDK120.79470167
84NME10.74800340
85CDK190.74566029
86AKT30.73626559
87PRKCG0.73599255
88CSNK1A1L0.72876793
89MAP3K110.72515576
90RPS6KA50.72100916
91STK40.71054645
92CAMK40.70752952
93ERN10.70520618
94MAP2K60.70391551
95DMPK0.69935768
96TESK20.69008610
97MAPKAPK50.68503760
98CSNK1G20.68361628
99ALK0.67597249
100GRK10.65319631
101TRIB30.64816477
102STK390.63814742
103DYRK1A0.63489324
104MELK0.62605623
105EPHA40.62490829
106BRAF0.61804475
107BCR0.60137929
108CSNK2A20.59440302
109ACVR1B0.58921336
110CDK10.57419311
111CAMK10.57238756
112CSNK1E0.55484492
113MAP3K100.55267837
114EPHB20.54773124
115CDK20.52744786
116BMPR20.52687374
117CSNK2A10.49821799
118PIM10.49707112
119GRK70.48639351
120CHEK20.48271498
121CDK40.47313419
122CDK70.47289524
123CAMK1D0.46757346
124IRAK30.45636773
125EIF2AK30.44468040
126TEC0.43604684
127EIF2AK20.42007683
128SMG10.41719934
129TSSK60.41449721
130IRAK10.41237604
131TGFBR10.40524705
132PRKCI0.38856349
133WNK30.38781283
134AURKA0.38633914
135STK38L0.38024100
136RPS6KB10.37702265
137CAMKK20.37688484
138NTRK20.37100167
139MAPK110.37038833
140UHMK10.37023021
141MAPK90.36994483
142CAMK1G0.35950014
143PRKDC0.35439233
144SCYL20.34706675
145OXSR10.34636002
146PLK10.33686838
147ILK0.32969318
148MAP3K50.32873217
149PRKCZ0.32736800
150BTK0.31760429
151CSNK1D0.30807597
152ATM0.30614770
153GRK50.30273648
154DYRK30.29729897
155MAPK140.28690560
156IRAK20.27582331

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.27908152
2DNA replication_Homo sapiens_hsa030303.65614373
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.12644446
4Mismatch repair_Homo sapiens_hsa034302.43248814
5Folate biosynthesis_Homo sapiens_hsa007902.11297323
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10492743
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08636092
8Homologous recombination_Homo sapiens_hsa034402.05270141
9Phototransduction_Homo sapiens_hsa047441.97065946
10Base excision repair_Homo sapiens_hsa034101.91062811
11Propanoate metabolism_Homo sapiens_hsa006401.90342377
12Basal transcription factors_Homo sapiens_hsa030221.90295343
13One carbon pool by folate_Homo sapiens_hsa006701.88111815
14Fatty acid degradation_Homo sapiens_hsa000711.75830170
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75129216
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75026141
17Nicotine addiction_Homo sapiens_hsa050331.73030226
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72921717
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70645701
20Protein export_Homo sapiens_hsa030601.67395971
21Peroxisome_Homo sapiens_hsa041461.63343531
22Sulfur relay system_Homo sapiens_hsa041221.61270166
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58710393
24Pyrimidine metabolism_Homo sapiens_hsa002401.58321689
25Butanoate metabolism_Homo sapiens_hsa006501.57978141
26Spliceosome_Homo sapiens_hsa030401.55868455
27Cell cycle_Homo sapiens_hsa041101.50960635
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.50372695
29N-Glycan biosynthesis_Homo sapiens_hsa005101.46858086
30Olfactory transduction_Homo sapiens_hsa047401.45503247
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.40131892
32Purine metabolism_Homo sapiens_hsa002301.34140339
33Proteasome_Homo sapiens_hsa030501.33480499
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32602160
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.27355518
36Nucleotide excision repair_Homo sapiens_hsa034201.23347019
37mRNA surveillance pathway_Homo sapiens_hsa030151.19304096
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17897979
39RNA polymerase_Homo sapiens_hsa030201.17690736
40Pyruvate metabolism_Homo sapiens_hsa006201.17079650
41Vitamin B6 metabolism_Homo sapiens_hsa007501.16960565
42Selenocompound metabolism_Homo sapiens_hsa004501.14528696
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.14090971
44RNA degradation_Homo sapiens_hsa030181.13652900
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11932747
46Carbon metabolism_Homo sapiens_hsa012001.10551636
47Fatty acid metabolism_Homo sapiens_hsa012121.09995200
48Systemic lupus erythematosus_Homo sapiens_hsa053221.09195972
49Insulin secretion_Homo sapiens_hsa049111.07286765
50Circadian entrainment_Homo sapiens_hsa047131.01615893
51Biosynthesis of amino acids_Homo sapiens_hsa012301.00483724
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00031670
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95591724
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.95571342
55Circadian rhythm_Homo sapiens_hsa047100.95414113
56GABAergic synapse_Homo sapiens_hsa047270.95364928
57p53 signaling pathway_Homo sapiens_hsa041150.94930129
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94075263
59Synaptic vesicle cycle_Homo sapiens_hsa047210.93621701
60* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92838228
61Morphine addiction_Homo sapiens_hsa050320.92739192
62Fanconi anemia pathway_Homo sapiens_hsa034600.89844782
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89563735
64Lysine degradation_Homo sapiens_hsa003100.89390710
65Tryptophan metabolism_Homo sapiens_hsa003800.88475794
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88100501
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87771178
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87620631
69beta-Alanine metabolism_Homo sapiens_hsa004100.87195580
70RNA transport_Homo sapiens_hsa030130.85610140
71Chemical carcinogenesis_Homo sapiens_hsa052040.80171588
72Taste transduction_Homo sapiens_hsa047420.79624569
73Dopaminergic synapse_Homo sapiens_hsa047280.78740029
74Parkinsons disease_Homo sapiens_hsa050120.78694887
75Non-homologous end-joining_Homo sapiens_hsa034500.78612291
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78106853
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76759144
78Vitamin digestion and absorption_Homo sapiens_hsa049770.74497006
79Glucagon signaling pathway_Homo sapiens_hsa049220.74383053
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73888595
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73373760
82Alcoholism_Homo sapiens_hsa050340.71717673
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69773487
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67867496
85Epstein-Barr virus infection_Homo sapiens_hsa051690.67652385
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67114300
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65874893
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64874073
89Cholinergic synapse_Homo sapiens_hsa047250.64684706
90Notch signaling pathway_Homo sapiens_hsa043300.63706571
91Starch and sucrose metabolism_Homo sapiens_hsa005000.62280353
92Calcium signaling pathway_Homo sapiens_hsa040200.62279366
93Huntingtons disease_Homo sapiens_hsa050160.57665617
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55841748
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54615162
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54175139
97Oocyte meiosis_Homo sapiens_hsa041140.52496264
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52278746
99Caffeine metabolism_Homo sapiens_hsa002320.51807311
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51421859
101Phenylalanine metabolism_Homo sapiens_hsa003600.51142576
102* Metabolic pathways_Homo sapiens_hsa011000.49242345
103Alzheimers disease_Homo sapiens_hsa050100.45853676
104Fatty acid elongation_Homo sapiens_hsa000620.45790035
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44767530
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44762761
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44651300
108Oxidative phosphorylation_Homo sapiens_hsa001900.44038356
109Cardiac muscle contraction_Homo sapiens_hsa042600.43865430
110Amphetamine addiction_Homo sapiens_hsa050310.42616663
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41972237
112TGF-beta signaling pathway_Homo sapiens_hsa043500.41576080
113Viral carcinogenesis_Homo sapiens_hsa052030.40860685
114Steroid biosynthesis_Homo sapiens_hsa001000.39968492
115Complement and coagulation cascades_Homo sapiens_hsa046100.39275070
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38867159
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38092009
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36088622
119Nitrogen metabolism_Homo sapiens_hsa009100.35573009
120Sulfur metabolism_Homo sapiens_hsa009200.35412519
121Insulin signaling pathway_Homo sapiens_hsa049100.33046312
122Retinol metabolism_Homo sapiens_hsa008300.32738389
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27754625
124Hippo signaling pathway_Homo sapiens_hsa043900.25212451
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.23085800
126Sphingolipid metabolism_Homo sapiens_hsa006000.19793367
127Thyroid cancer_Homo sapiens_hsa052160.18102794
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14025036
129MicroRNAs in cancer_Homo sapiens_hsa052060.11647272
130Basal cell carcinoma_Homo sapiens_hsa052170.11221895
131Fat digestion and absorption_Homo sapiens_hsa049750.10044935
132Regulation of autophagy_Homo sapiens_hsa041400.09505121
133HTLV-I infection_Homo sapiens_hsa051660.09139586
134Bladder cancer_Homo sapiens_hsa052190.08910361
135Arginine biosynthesis_Homo sapiens_hsa002200.08098762
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07002201
137Fructose and mannose metabolism_Homo sapiens_hsa000510.06645707
138Hedgehog signaling pathway_Homo sapiens_hsa043400.05193448
139Fatty acid biosynthesis_Homo sapiens_hsa000610.05176953

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