GATM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.81321646
2drug catabolic process (GO:0042737)7.53732058
3glyoxylate metabolic process (GO:0046487)7.52265153
4fatty acid elongation (GO:0030497)7.48553273
5ensheathment of neurons (GO:0007272)6.92105087
6axon ensheathment (GO:0008366)6.92105087
7myelination (GO:0042552)6.87359280
8epoxygenase P450 pathway (GO:0019373)6.86032112
9negative regulation of fibrinolysis (GO:0051918)6.75092493
10regulation of fibrinolysis (GO:0051917)6.67382505
11myelin maintenance (GO:0043217)6.55384945
12cellular glucuronidation (GO:0052695)6.36602748
13omega-hydroxylase P450 pathway (GO:0097267)6.21534854
14uronic acid metabolic process (GO:0006063)6.06812716
15glucuronate metabolic process (GO:0019585)6.06812716
16regulation of protein activation cascade (GO:2000257)5.97743465
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.92052917
18L-phenylalanine metabolic process (GO:0006558)5.92052917
19negative regulation of cholesterol transport (GO:0032375)5.85447953
20negative regulation of sterol transport (GO:0032372)5.85447953
21complement activation, alternative pathway (GO:0006957)5.80514736
22fibrinolysis (GO:0042730)5.72618041
23urea metabolic process (GO:0019627)5.61072826
24long-chain fatty acid biosynthetic process (GO:0042759)5.52772979
25regulation of complement activation (GO:0030449)5.52643726
26bile acid biosynthetic process (GO:0006699)5.51251309
27drug metabolic process (GO:0017144)5.36239590
28ethanol oxidation (GO:0006069)5.29065808
29response to methylmercury (GO:0051597)5.16108268
30nitrogen cycle metabolic process (GO:0071941)5.11450052
31bile acid metabolic process (GO:0008206)5.04661255
32serine family amino acid catabolic process (GO:0009071)5.01573622
33oxidative demethylation (GO:0070989)4.99543895
34amino-acid betaine metabolic process (GO:0006577)4.96179937
35blood coagulation, intrinsic pathway (GO:0007597)4.92462706
36protein carboxylation (GO:0018214)4.85411201
37peptidyl-glutamic acid carboxylation (GO:0017187)4.85411201
38phenylpropanoid metabolic process (GO:0009698)4.74577618
39urea cycle (GO:0000050)4.64859678
40negative regulation of neurotransmitter secretion (GO:0046929)4.62356684
41negative regulation of neurotransmitter transport (GO:0051589)4.61759547
42phospholipid efflux (GO:0033700)4.57584067
43aromatic amino acid family catabolic process (GO:0009074)4.55239317
44negative regulation of protein localization to cell surface (GO:2000009)4.51664194
45regulation of triglyceride catabolic process (GO:0010896)4.50586563
46regulation of collateral sprouting (GO:0048670)4.44939715
47bile acid and bile salt transport (GO:0015721)4.37863659
48glycine metabolic process (GO:0006544)4.37327053
49establishment of mitochondrion localization (GO:0051654)4.33452815
50fat-soluble vitamin biosynthetic process (GO:0042362)4.33319801
51cholesterol biosynthetic process (GO:0006695)4.32078822
52oligodendrocyte differentiation (GO:0048709)4.31850714
53amyloid precursor protein metabolic process (GO:0042982)4.30056168
54negative regulation of hemostasis (GO:1900047)4.28908583
55negative regulation of blood coagulation (GO:0030195)4.28908583
56L-amino acid import (GO:0043092)4.27746200
57regulation of cholesterol esterification (GO:0010872)4.19482642
58intestinal cholesterol absorption (GO:0030299)4.18728926
59ethanol metabolic process (GO:0006067)4.14922301
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.14545843
61aminoglycoside antibiotic metabolic process (GO:0030647)4.11799593
62triglyceride homeostasis (GO:0070328)4.10947238
63acylglycerol homeostasis (GO:0055090)4.10947238
64positive regulation of oligodendrocyte differentiation (GO:0048714)4.07049242
65astrocyte development (GO:0014002)4.06663341
66* response to mercury ion (GO:0046689)4.00540864
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.98319347
68negative regulation of lipase activity (GO:0060192)3.98283341
69hormone catabolic process (GO:0042447)3.96534560
70S-adenosylmethionine metabolic process (GO:0046500)3.95329938
71high-density lipoprotein particle remodeling (GO:0034375)3.95279100
72negative regulation of coagulation (GO:0050819)3.91216853
73polyketide metabolic process (GO:0030638)3.90614120
74doxorubicin metabolic process (GO:0044598)3.90614120
75daunorubicin metabolic process (GO:0044597)3.90614120
76alkaloid metabolic process (GO:0009820)3.86822813
77cholesterol efflux (GO:0033344)3.85081494
78regulation of plasminogen activation (GO:0010755)3.84760553
79import into cell (GO:0098657)3.83531473
80protein activation cascade (GO:0072376)3.83185722
81negative regulation of wound healing (GO:0061045)3.83156192
82sterol biosynthetic process (GO:0016126)3.83098886
83long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.75313375
84macromolecular complex remodeling (GO:0034367)3.75242445
85plasma lipoprotein particle remodeling (GO:0034369)3.75242445
86protein-lipid complex remodeling (GO:0034368)3.75242445
87response to lipoprotein particle (GO:0055094)3.75042321
88reverse cholesterol transport (GO:0043691)3.74424590
89regulation of lipoprotein metabolic process (GO:0050746)3.72449895
90alpha-linolenic acid metabolic process (GO:0036109)3.70352915
91eye photoreceptor cell differentiation (GO:0001754)3.67241775
92photoreceptor cell differentiation (GO:0046530)3.67241775
93steroid catabolic process (GO:0006706)3.64412331
94very long-chain fatty acid metabolic process (GO:0000038)3.62744122
95serine family amino acid metabolic process (GO:0009069)3.62030741
96asymmetric protein localization (GO:0008105)3.59300396
97peripheral nervous system axon ensheathment (GO:0032292)3.59205070
98myelination in peripheral nervous system (GO:0022011)3.59205070
99substantia nigra development (GO:0021762)3.56361578
100positive regulation of blood coagulation (GO:0030194)3.56136747
101positive regulation of hemostasis (GO:1900048)3.56136747
102apical protein localization (GO:0045176)3.55733670
103peptidyl-tyrosine autophosphorylation (GO:0038083)3.54931157
104isoprenoid biosynthetic process (GO:0008299)3.54688294
105sodium-independent organic anion transport (GO:0043252)3.54558277
106long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.52363447
107acute-phase response (GO:0006953)3.51851088
108flavonoid metabolic process (GO:0009812)3.51733543
109complement activation (GO:0006956)3.49157743
110glycerophospholipid catabolic process (GO:0046475)3.48961295
111very-low-density lipoprotein particle assembly (GO:0034379)3.44711458
112positive regulation of triglyceride lipase activity (GO:0061365)3.42614060
113positive regulation of lipoprotein lipase activity (GO:0051006)3.42614060
114complement activation, classical pathway (GO:0006958)3.41985971
115regulation of humoral immune response (GO:0002920)3.39736402
116amino acid import (GO:0043090)3.38689706
117negative regulation of protein activation cascade (GO:2000258)3.36261565
118positive regulation of coagulation (GO:0050820)3.36191190
119carnitine metabolic process (GO:0009437)3.36108072
120alpha-amino acid catabolic process (GO:1901606)3.33703537
121presynaptic membrane organization (GO:0097090)3.33529301
122primary alcohol catabolic process (GO:0034310)3.33234412
123magnesium ion transport (GO:0015693)3.32532058
124arginine metabolic process (GO:0006525)3.32311968
125neuron remodeling (GO:0016322)3.31990697
126glutamate metabolic process (GO:0006536)3.30342819
127fatty-acyl-CoA biosynthetic process (GO:0046949)3.28690953
128xenobiotic metabolic process (GO:0006805)3.27774079
129response to redox state (GO:0051775)3.27668915
130amyloid precursor protein catabolic process (GO:0042987)3.25062280
131response to lead ion (GO:0010288)3.23433314
132drug transmembrane transport (GO:0006855)3.22220540
133fatty-acyl-CoA metabolic process (GO:0035337)3.19771021
134protein palmitoylation (GO:0018345)3.18613793
135negative regulation of lipid transport (GO:0032369)3.16385059
136phospholipid homeostasis (GO:0055091)3.11909714
137monocarboxylic acid catabolic process (GO:0072329)3.11381143
138plasma lipoprotein particle clearance (GO:0034381)3.11024952
139positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.10722392
140negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.09504888
141tyrosine metabolic process (GO:0006570)3.09260147
142regulation of bile acid biosynthetic process (GO:0070857)3.08018775
143regulation of lipoprotein particle clearance (GO:0010984)3.07131445
144leukocyte migration involved in inflammatory response (GO:0002523)3.03853187
145positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.02805577
146membrane tubulation (GO:0097320)2.99733139
147GPI anchor biosynthetic process (GO:0006506)2.99079320
148axon development (GO:0061564)2.96602760
149glutathione biosynthetic process (GO:0006750)2.95929692
150glycosylceramide metabolic process (GO:0006677)2.94681715
151neurotransmitter uptake (GO:0001504)2.89050757
152adult walking behavior (GO:0007628)2.88975967
153L-phenylalanine catabolic process (GO:0006559)2.88451232
154erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88451232
155nucleotide transmembrane transport (GO:1901679)2.88021092
156heme transport (GO:0015886)2.86695189
157glycine transport (GO:0015816)2.86155075
158adhesion of symbiont to host cell (GO:0044650)2.85366198
159virion attachment to host cell (GO:0019062)2.85366198
160nonribosomal peptide biosynthetic process (GO:0019184)2.83826477
161presynaptic membrane assembly (GO:0097105)2.82650949
162enteric nervous system development (GO:0048484)2.82259330
163GPI anchor metabolic process (GO:0006505)2.80844896
164iron coordination entity transport (GO:1901678)2.77143939
165positive regulation of glial cell differentiation (GO:0045687)2.75600245
166acyl-CoA biosynthetic process (GO:0071616)2.72632755
167thioester biosynthetic process (GO:0035384)2.72632755
168positive regulation of cellular amine metabolic process (GO:0033240)2.72456552
169glial cell development (GO:0021782)2.71848107
170detection of temperature stimulus involved in sensory perception (GO:0050961)2.66802071
171detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.66802071
172negative regulation of axonogenesis (GO:0050771)2.65146562
173peptide biosynthetic process (GO:0043043)2.64377106
174limb bud formation (GO:0060174)2.64274090
175positive regulation of gliogenesis (GO:0014015)2.63384972
176negative regulation of execution phase of apoptosis (GO:1900118)2.62324937
177peptidyl-cysteine modification (GO:0018198)2.60201180
178negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.59089716
179negative regulation of macroautophagy (GO:0016242)2.57240698
180negative regulation of JUN kinase activity (GO:0043508)2.55576194
181peripheral nervous system development (GO:0007422)2.53778000
182Leydig cell differentiation (GO:0033327)2.53643883
183positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.52239777
184nerve growth factor signaling pathway (GO:0038180)2.52113890
185negative regulation of chemokine production (GO:0032682)2.50349010
186neuron cell-cell adhesion (GO:0007158)2.43781410
187cerebral cortex radially oriented cell migration (GO:0021799)2.42185640
188glial cell differentiation (GO:0010001)2.40763572
189preassembly of GPI anchor in ER membrane (GO:0016254)2.40136218
190nucleotide transport (GO:0006862)2.37089584
191regulation of hydrogen peroxide-induced cell death (GO:1903205)2.36738913
192regulation of autophagic vacuole assembly (GO:2000785)2.35934213
193extracellular matrix assembly (GO:0085029)2.35028628
194neuronal action potential propagation (GO:0019227)2.34429831
195organ growth (GO:0035265)2.34384255
196axon ensheathment in central nervous system (GO:0032291)12.0257273
197central nervous system myelination (GO:0022010)12.0257273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.64400112
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.97438919
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.58301140
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.22477886
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00487540
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.79292776
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09237969
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92006741
9* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.79458431
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75581512
11GBX2_23144817_ChIP-Seq_PC3_Human2.69889022
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17399920
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16410504
14AR_21572438_ChIP-Seq_LNCaP_Human2.07792025
15TAF15_26573619_Chip-Seq_HEK293_Human2.06937076
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05616523
17* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03627458
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01632679
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00895498
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96496227
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88849162
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86769173
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86616645
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86616645
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84667216
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83498675
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82411659
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75324165
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75013724
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74487582
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.74334270
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74178366
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73402605
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72340541
35EZH2_22144423_ChIP-Seq_EOC_Human1.70849289
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.66912121
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.66691901
38ER_23166858_ChIP-Seq_MCF-7_Human1.62939323
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62483787
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58970451
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57119900
42* EED_16625203_ChIP-ChIP_MESCs_Mouse1.51904683
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51236913
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50210956
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48924535
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.42018627
47* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41986598
48VDR_22108803_ChIP-Seq_LS180_Human1.40379306
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37820371
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36875717
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36077218
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36077218
53DROSHA_22980978_ChIP-Seq_HELA_Human1.35634959
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.34577726
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34531911
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31270414
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.30029951
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29606590
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.27225741
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.26882283
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25198773
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24708262
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23538049
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23278030
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.20326123
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18483910
67IGF1R_20145208_ChIP-Seq_DFB_Human1.18335559
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.17328255
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.17050847
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15586998
71TP53_18474530_ChIP-ChIP_U2OS_Human1.15398570
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14753929
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.14115606
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12353636
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11723144
76P300_19829295_ChIP-Seq_ESCs_Human1.11236793
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08982411
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.08723029
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08397995
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08241988
81* EOMES_21245162_ChIP-Seq_HESCs_Human1.08121443
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07889578
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06506763
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04066026
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.03582107
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02828243
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02201095
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.02200546
89* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00032140
90NANOG_19829295_ChIP-Seq_ESCs_Human0.99300955
91SOX2_19829295_ChIP-Seq_ESCs_Human0.99300955
92STAT3_23295773_ChIP-Seq_U87_Human0.99174442
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98248252
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97979330
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97571220
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.97463005
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97362716
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97179459
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96632943
100GATA1_19941826_ChIP-Seq_K562_Human0.95976613
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94770312
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94122204
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93884986
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93356574
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93025408
106HTT_18923047_ChIP-ChIP_STHdh_Human0.92862186
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91830567
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.91179019
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91010123
110CBP_21632823_ChIP-Seq_H3396_Human0.89992706
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89598694
112* CMYC_18555785_Chip-Seq_ESCs_Mouse0.89130594
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88308520
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.88278463
115* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86380325
116KDM2B_26808549_Chip-Seq_REH_Human0.84937619
117* P300_18555785_Chip-Seq_ESCs_Mouse0.83960646
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83889390
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83889390
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83889390
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.83868169
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83763075
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83323045
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.83046301
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82733776
126AHR_22903824_ChIP-Seq_MCF-7_Human0.82381996
127TRIM28_21343339_ChIP-Seq_HEK293_Human0.81668076
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81528807
129SOX2_20726797_ChIP-Seq_SW620_Human0.81421824
130SMAD4_21799915_ChIP-Seq_A2780_Human0.81390615
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81171625
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.81168459
133EGR1_19032775_ChIP-ChIP_M12_Human0.80905994
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.78918171
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78389203
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76790666
137P53_22387025_ChIP-Seq_ESCs_Mouse0.76685111
138REST_21632747_ChIP-Seq_MESCs_Mouse0.76661607
139* SMAD4_21741376_ChIP-Seq_HESCs_Human0.76462534
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76439963
141* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.76412565
142RUNX1_27457419_Chip-Seq_LIVER_Mouse0.75707726
143BCAT_22108803_ChIP-Seq_LS180_Human0.75040324
144CLOCK_20551151_ChIP-Seq_293T_Human0.74866023
145* NANOG_18555785_Chip-Seq_ESCs_Mouse0.73903441
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.73695948
147* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73167074
148* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.73097635
149* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.72981351
150HNFA_21074721_ChIP-Seq_CACO-2_Human0.72373485
151REST_18959480_ChIP-ChIP_MESCs_Mouse0.72099396
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72093500
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71988777
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.71860505
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71607073
156PHF8_20622853_ChIP-Seq_HELA_Human0.71173192
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70533538
158CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70299994
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69773739
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.69188997
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.68996460
162GATA1_22025678_ChIP-Seq_K562_Human0.68492949
163NFYA_21822215_ChIP-Seq_K562_Human0.68391402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.88086405
2MP0000920_abnormal_myelination5.93444377
3MP0005365_abnormal_bile_salt5.86139592
4MP0005085_abnormal_gallbladder_physiolo5.76871104
5MP0005360_urolithiasis5.08905556
6MP0002138_abnormal_hepatobiliary_system4.32994362
7MP0008875_abnormal_xenobiotic_pharmacok4.09740810
8MP0003868_abnormal_feces_composition3.92290612
9MP0003252_abnormal_bile_duct3.87300901
10MP0003690_abnormal_glial_cell3.62764623
11MP0003950_abnormal_plasma_membrane3.18007099
12MP0004043_abnormal_pH_regulation3.07354496
13MP0003880_abnormal_central_pattern3.02778899
14MP0005171_absent_coat_pigmentation3.01913134
15MP0004885_abnormal_endolymph3.01798285
16MP0003329_amyloid_beta_deposits2.97906993
17MP0004742_abnormal_vestibular_system2.90001828
18MP0004270_analgesia2.81915880
19MP0010329_abnormal_lipoprotein_level2.59605320
20MP0003634_abnormal_glial_cell2.53590398
21MP0003195_calcinosis2.51368307
22MP0001529_abnormal_vocalization2.35706893
23MP0003136_yellow_coat_color2.35550812
24MP0002272_abnormal_nervous_system2.35532393
25MP0001486_abnormal_startle_reflex2.25590321
26MP0004142_abnormal_muscle_tone2.17678644
27MP0001905_abnormal_dopamine_level2.14746492
28MP0001485_abnormal_pinna_reflex2.13171638
29MP0009697_abnormal_copulation2.08704454
30MP0005410_abnormal_fertilization2.02085722
31MP0002876_abnormal_thyroid_physiology1.98401049
32MP0008260_abnormal_autophagy1.98157143
33MP0002064_seizures1.95963322
34MP0005409_darkened_coat_color1.93619683
35MP0005058_abnormal_lysosome_morphology1.93092293
36MP0004019_abnormal_vitamin_homeostasis1.90347427
37MP0002229_neurodegeneration1.85832297
38MP0003632_abnormal_nervous_system1.83876569
39MP0004147_increased_porphyrin_level1.80478449
40MP0000604_amyloidosis1.79337341
41MP0000778_abnormal_nervous_system1.77521258
42MP0005423_abnormal_somatic_nervous1.63725739
43MP0003631_nervous_system_phenotype1.61314579
44MP0003633_abnormal_nervous_system1.55224417
45MP0010678_abnormal_skin_adnexa1.54609997
46MP0002734_abnormal_mechanical_nocicepti1.43623045
47MP0004381_abnormal_hair_follicle1.43019267
48MP0004134_abnormal_chest_morphology1.41210057
49MP0001764_abnormal_homeostasis1.41105679
50MP0003191_abnormal_cellular_cholesterol1.39639110
51MP0009046_muscle_twitch1.37901547
52MP0000609_abnormal_liver_physiology1.36376258
53MP0000747_muscle_weakness1.36031158
54MP0001661_extended_life_span1.33332816
55MP0000462_abnormal_digestive_system1.31920096
56MP0009745_abnormal_behavioral_response1.31914913
57MP0000383_abnormal_hair_follicle1.31895111
58MP0003879_abnormal_hair_cell1.29141040
59MP0008569_lethality_at_weaning1.28975436
60MP0003635_abnormal_synaptic_transmissio1.28213368
61MP0004859_abnormal_synaptic_plasticity1.25297281
62MP0005408_hypopigmentation1.23528142
63MP0001970_abnormal_pain_threshold1.20727948
64MP0001440_abnormal_grooming_behavior1.19862591
65MP0000955_abnormal_spinal_cord1.19145254
66MP0001963_abnormal_hearing_physiology1.18725419
67MP0003806_abnormal_nucleotide_metabolis1.18568345
68MP0005451_abnormal_body_composition1.15451021
69MP0002066_abnormal_motor_capabilities/c1.12797529
70MP0002882_abnormal_neuron_morphology1.11387635
71MP0005332_abnormal_amino_acid1.11285601
72MP0001756_abnormal_urination1.10947998
73MP0001851_eye_inflammation1.07782944
74MP0002067_abnormal_sensory_capabilities1.06143523
75MP0002572_abnormal_emotion/affect_behav1.04706423
76MP0005551_abnormal_eye_electrophysiolog1.04686590
77MP0004145_abnormal_muscle_electrophysio1.03915676
78MP0005319_abnormal_enzyme/_coenzyme1.00767172
79MP0005623_abnormal_meninges_morphology0.98669221
80MP0005636_abnormal_mineral_homeostasis0.97136384
81MP0003172_abnormal_lysosome_physiology0.95882365
82MP0010368_abnormal_lymphatic_system0.95315566
83MP0002063_abnormal_learning/memory/cond0.93461199
84MP0002733_abnormal_thermal_nociception0.89965680
85MP0001299_abnormal_eye_distance/0.89803698
86MP0003878_abnormal_ear_physiology0.89746913
87MP0005377_hearing/vestibular/ear_phenot0.89746913
88MP0001177_atelectasis0.88988704
89MP0002752_abnormal_somatic_nervous0.88492107
90MP0001765_abnormal_ion_homeostasis0.87905066
91MP0005535_abnormal_body_temperature0.87515618
92MP0001958_emphysema0.87340773
93MP0003011_delayed_dark_adaptation0.86817336
94MP0003656_abnormal_erythrocyte_physiolo0.86257114
95MP0001666_abnormal_nutrient_absorption0.85494991
96MP0002295_abnormal_pulmonary_circulatio0.84964688
97MP0000647_abnormal_sebaceous_gland0.84751025
98MP0004924_abnormal_behavior0.82150143
99MP0005386_behavior/neurological_phenoty0.82150143
100MP0009840_abnormal_foam_cell0.82105842
101MP0002971_abnormal_brown_adipose0.78875913
102MP0005083_abnormal_biliary_tract0.78674828
103MP0008438_abnormal_cutaneous_collagen0.78361169
104MP0001984_abnormal_olfaction0.76338201
105MP0006082_CNS_inflammation0.76123210
106MP0005584_abnormal_enzyme/coenzyme_acti0.75023475
107MP0005195_abnormal_posterior_eye0.74926496
108MP0000598_abnormal_liver_morphology0.74501999
109MP0002168_other_aberrant_phenotype0.74298502
110MP0000566_synostosis0.73972858
111MP0000003_abnormal_adipose_tissue0.72695277
112MP0005670_abnormal_white_adipose0.71192412
113MP0009642_abnormal_blood_homeostasis0.71072790
114MP0010386_abnormal_urinary_bladder0.69559509
115MP0004036_abnormal_muscle_relaxation0.69133897
116MP0005645_abnormal_hypothalamus_physiol0.67940503
117MP0002638_abnormal_pupillary_reflex0.67741452
118MP0001968_abnormal_touch/_nociception0.67088922
119MP0004272_abnormal_basement_membrane0.66278725
120MP0003638_abnormal_response/metabolism_0.65868062
121MP0003300_gastrointestinal_ulcer0.63031838
122MP0003186_abnormal_redox_activity0.62869707
123MP0009053_abnormal_anal_canal0.62423767
124MP0005388_respiratory_system_phenotype0.61843131
125MP0002133_abnormal_respiratory_system0.61843131
126MP0005187_abnormal_penis_morphology0.61640072
127MP0000749_muscle_degeneration0.61159335
128MP0009643_abnormal_urine_homeostasis0.60881494
129MP0001915_intracranial_hemorrhage0.60801764
130MP0002118_abnormal_lipid_homeostasis0.60714854
131MP0000762_abnormal_tongue_morphology0.60551134
132MP0000639_abnormal_adrenal_gland0.60112774
133MP0008874_decreased_physiological_sensi0.60069802
134MP0001727_abnormal_embryo_implantation0.59260280
135MP0000026_abnormal_inner_ear0.59164259
136MP0003075_altered_response_to0.58310293
137MP0002152_abnormal_brain_morphology0.57628129
138MP0002090_abnormal_vision0.57451503
139MP0002136_abnormal_kidney_physiology0.55805069
140MP0002078_abnormal_glucose_homeostasis0.54826379
141MP0008872_abnormal_physiological_respon0.53642266
142MP0005220_abnormal_exocrine_pancreas0.53571999
143MP0002928_abnormal_bile_duct0.53389523
144MP0005395_other_phenotype0.53234568
145MP0005376_homeostasis/metabolism_phenot0.53015720
146MP0005167_abnormal_blood-brain_barrier0.49836026
147MP0008469_abnormal_protein_level0.49035004
148MP0005166_decreased_susceptibility_to0.47750589
149MP0002822_catalepsy0.45063056
150MP0009763_increased_sensitivity_to0.44966443
151MP0003183_abnormal_peptide_metabolism0.44822542
152MP0001501_abnormal_sleep_pattern0.43783425
153MP0005646_abnormal_pituitary_gland0.43656552
154MP0009764_decreased_sensitivity_to0.42234087
155MP0003959_abnormal_lean_body0.39006672
156MP0002249_abnormal_larynx_morphology0.38525941
157MP0002909_abnormal_adrenal_gland0.38347386
158MP0002069_abnormal_eating/drinking_beha0.36631671
159MP0003953_abnormal_hormone_level0.36471846
160MP0006036_abnormal_mitochondrial_physio0.35814109

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.42371998
2Deep venous thrombosis (HP:0002625)7.94279135
3Complement deficiency (HP:0004431)7.34282533
4Prolonged partial thromboplastin time (HP:0003645)6.69164083
5Hypobetalipoproteinemia (HP:0003563)6.66101385
6Neurofibrillary tangles (HP:0002185)6.01501209
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.91257229
8Degeneration of the lateral corticospinal tracts (HP:0002314)5.91257229
9Abnormality of complement system (HP:0005339)5.70912726
10Systemic lupus erythematosus (HP:0002725)5.64717839
11Conjugated hyperbilirubinemia (HP:0002908)4.93289035
12Intrahepatic cholestasis (HP:0001406)4.90911977
13Peripheral hypomyelination (HP:0007182)4.74331424
14Joint hemorrhage (HP:0005261)4.63947410
15Glomerulonephritis (HP:0000099)4.57717841
16Onion bulb formation (HP:0003383)4.51435998
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.42828941
18Abnormal auditory evoked potentials (HP:0006958)4.36998868
19Segmental peripheral demyelination/remyelination (HP:0003481)4.31444086
20Abnormality of the corticospinal tract (HP:0002492)4.27704240
21Increased circulating renin level (HP:0000848)4.25181016
22Fat malabsorption (HP:0002630)4.22813374
23Cerebral inclusion bodies (HP:0100314)4.20016178
24Hyperlipoproteinemia (HP:0010980)4.18824915
25Xanthomatosis (HP:0000991)4.10483405
26Metabolic alkalosis (HP:0200114)4.09456529
27Cerebral hypomyelination (HP:0006808)4.06755294
28Hypokalemic alkalosis (HP:0001949)4.00583643
29Steatorrhea (HP:0002570)3.93195018
30Hypolipoproteinemia (HP:0010981)3.92800845
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.89155829
32Hypomagnesemia (HP:0002917)3.88100687
33Abnormality of the common coagulation pathway (HP:0010990)3.86571420
34Parakeratosis (HP:0001036)3.79554280
35Sensory axonal neuropathy (HP:0003390)3.77781336
36Hyperglycinemia (HP:0002154)3.66684626
37Generalized aminoaciduria (HP:0002909)3.56072744
38Supranuclear gaze palsy (HP:0000605)3.52082621
39Ankle clonus (HP:0011448)3.44029820
40Axonal loss (HP:0003447)3.37467363
41Abnormality of serine family amino acid metabolism (HP:0010894)3.36105916
42Abnormality of glycine metabolism (HP:0010895)3.36105916
43Insidious onset (HP:0003587)3.30092510
44Termporal pattern (HP:0011008)3.30092510
45Hyperglycinuria (HP:0003108)3.29785748
46Abnormality of pyrimidine metabolism (HP:0004353)3.27885430
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24493922
48Hyperammonemia (HP:0001987)3.18759921
49Rickets (HP:0002748)3.17272648
50Nephritis (HP:0000123)3.15010089
51Spastic gait (HP:0002064)3.14682901
52Spontaneous abortion (HP:0005268)3.13932821
53Osteomalacia (HP:0002749)3.10704066
54Abnormality of magnesium homeostasis (HP:0004921)3.09483194
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.06741878
56Stridor (HP:0010307)3.01092680
57Recurrent gram-negative bacterial infections (HP:0005420)2.98608519
58Leukodystrophy (HP:0002415)2.98547320
59Intention tremor (HP:0002080)2.95878742
60Clumsiness (HP:0002312)2.88110382
61Slow saccadic eye movements (HP:0000514)2.87218240
62Alacrima (HP:0000522)2.84165495
63Hyperphosphaturia (HP:0003109)2.81984668
64Dysmetria (HP:0001310)2.81927596
65Retinal dysplasia (HP:0007973)2.70465950
66Glycosuria (HP:0003076)2.69620939
67Abnormality of urine glucose concentration (HP:0011016)2.69620939
68Increased serum pyruvate (HP:0003542)2.68707592
69Abnormality of glycolysis (HP:0004366)2.68707592
70Abnormality of the intrinsic pathway (HP:0010989)2.68158791
71Hypoplasia of the iris (HP:0007676)2.66733195
72CNS hypomyelination (HP:0003429)2.65869979
73Abnormality of nucleobase metabolism (HP:0010932)2.61181981
74Scanning speech (HP:0002168)2.59674825
75Gout (HP:0001997)2.59075244
76Proximal tubulopathy (HP:0000114)2.58400638
77Spastic paraparesis (HP:0002313)2.57747810
78Myokymia (HP:0002411)2.56094008
79Peripheral demyelination (HP:0011096)2.53380362
80Abnormality of fatty-acid metabolism (HP:0004359)2.50492665
81Premature skin wrinkling (HP:0100678)2.46142917
82Hypercholesterolemia (HP:0003124)2.44734392
83Hypoplastic pelvis (HP:0008839)2.43937686
84Vascular calcification (HP:0004934)2.43906764
85Mitral stenosis (HP:0001718)2.41048717
86Epidermoid cyst (HP:0200040)2.41041506
87Hypoalphalipoproteinemia (HP:0003233)2.40895635
88Abnormality of serum amino acid levels (HP:0003112)2.40353019
89Delayed CNS myelination (HP:0002188)2.36025188
90Abnormality of vitamin metabolism (HP:0100508)2.35601644
91Cerebral hemorrhage (HP:0001342)2.35377155
92Hyperactive renin-angiotensin system (HP:0000841)2.34600023
93Sensorimotor neuropathy (HP:0007141)2.33966678
94Foot dorsiflexor weakness (HP:0009027)2.33059735
95Pheochromocytoma (HP:0002666)2.32332765
96Renal salt wasting (HP:0000127)2.32161061
97Morphological abnormality of the inner ear (HP:0011390)2.31352270
98Polyuria (HP:0000103)2.31220158
99White forelock (HP:0002211)2.31141333
100Abnormal urine phosphate concentration (HP:0012599)2.30633852
101Abnormality of purine metabolism (HP:0004352)2.30609566
102Patchy hypopigmentation of hair (HP:0011365)2.29587896
103Abnormal drinking behavior (HP:0030082)2.29245207
104Polydipsia (HP:0001959)2.29245207
105Autoamputation (HP:0001218)2.27749984
106Diaphragmatic weakness (HP:0009113)2.27409807
107Spastic tetraparesis (HP:0001285)2.23888964
108Hepatosplenomegaly (HP:0001433)2.23837075
109Decreased lacrimation (HP:0000633)2.21715044
110Irritability (HP:0000737)2.20396681
111Absent septum pellucidum (HP:0001331)2.15703914
112Paraparesis (HP:0002385)2.12908194
113Congenital ichthyosiform erythroderma (HP:0007431)2.11614531
114Hypokalemia (HP:0002900)2.11336060
115Abnormality of methionine metabolism (HP:0010901)2.09944494
116Abnormality of the foot musculature (HP:0001436)2.09636518
117Cholecystitis (HP:0001082)2.09436170
118Abnormal gallbladder physiology (HP:0012438)2.09436170
119Anteriorly placed anus (HP:0001545)2.09241776
120Hydroxyprolinuria (HP:0003080)2.09167384
121Abnormality of proline metabolism (HP:0010907)2.09167384
122Abnormal urine output (HP:0012590)2.09094357
123Decreased motor nerve conduction velocity (HP:0003431)2.07864962
124Bifid scrotum (HP:0000048)2.07271739
125Muscle fiber splitting (HP:0003555)2.06781835
126Clonus (HP:0002169)2.06645392
127Cardiovascular calcification (HP:0011915)2.05342056
128Gingival bleeding (HP:0000225)2.04448473
129Hemorrhage of the eye (HP:0011885)2.03400574
130Gonadal dysgenesis (HP:0000133)2.02713624
131Neuroendocrine neoplasm (HP:0100634)2.00984320
132Metabolic acidosis (HP:0001942)2.00938748
133Abnormality of chloride homeostasis (HP:0011422)2.00931828
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99277158
135Abnormality of renal excretion (HP:0011036)1.99002735
136Alkalosis (HP:0001948)1.98395077
137Hyperaldosteronism (HP:0000859)1.98324315
138Hypophosphatemic rickets (HP:0004912)1.97862994
139Abnormality of renin-angiotensin system (HP:0000847)1.97455530
140Methylmalonic acidemia (HP:0002912)1.97063359
141Elevated alkaline phosphatase (HP:0003155)1.96372521
142Hammertoe (HP:0001765)1.93933260
143Neonatal onset (HP:0003623)1.93780129
144Hyperbilirubinemia (HP:0002904)1.93484542
145Poor speech (HP:0002465)1.92266945
146Action tremor (HP:0002345)1.91272130
147Lower limb muscle weakness (HP:0007340)1.90849151
148Thickened helices (HP:0000391)1.89850200
149Reduced antithrombin III activity (HP:0001976)1.89553677
150Akinesia (HP:0002304)1.88911581
151Split foot (HP:0001839)1.88239932
152Atrioventricular block (HP:0001678)1.87390833
153Distal sensory impairment (HP:0002936)1.86689727
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86007498
155Vacuolated lymphocytes (HP:0001922)1.85129412
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84169663
157Confusion (HP:0001289)1.83195469
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.83015377
159Abnormal enzyme/coenzyme activity (HP:0012379)1.81518294
160Choreoathetosis (HP:0001266)1.80248197
161Potter facies (HP:0002009)1.79567585
162Facial shape deformation (HP:0011334)1.79567585
163Purpura (HP:0000979)1.79377536
164Urinary incontinence (HP:0000020)1.78397947
165Abnormality of alkaline phosphatase activity (HP:0004379)1.77279161
166Abnormality of the septum pellucidum (HP:0007375)1.75834113
167Ulnar claw (HP:0001178)1.75042128
168Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74160984
169Hypoplasia of the uterus (HP:0000013)1.73217132
170Neuronal loss in central nervous system (HP:0002529)1.73010290
171Urinary urgency (HP:0000012)1.72578280
172Arthropathy (HP:0003040)1.71969491
173Hypophosphatemia (HP:0002148)1.69341499
174Abnormality of the Achilles tendon (HP:0005109)1.69229009
175Partial agenesis of the corpus callosum (HP:0001338)1.69163112
176Progressive neurologic deterioration (HP:0002344)1.68902879
177Retinal atrophy (HP:0001105)1.68515763
178Cholelithiasis (HP:0001081)1.67949860
179Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67872977
180Thrombophlebitis (HP:0004418)1.67708875
181Fair hair (HP:0002286)1.67678517
182Pulmonary embolism (HP:0002204)1.67233793
183Prolonged neonatal jaundice (HP:0006579)1.67093047
184Abnormal gallbladder morphology (HP:0012437)1.66678875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.53212166
2OXSR15.14531758
3EPHB13.79951098
4WNK43.71103892
5MAPKAPK53.11918848
6NTRK32.99904391
7PKN12.85605242
8RIPK12.78668487
9SGK22.42436902
10PBK2.37817842
11WNK12.17103085
12LIMK12.11046722
13NEK92.00890014
14MET2.00295547
15PIK3CG1.93297383
16BCR1.93054817
17WNK31.79943759
18SGK31.77834381
19UHMK11.76894087
20TESK21.74934043
21FGFR21.70570911
22SGK4941.69859043
23SGK2231.69859043
24NTRK11.64878820
25CSNK1G31.62251346
26CSNK1A1L1.61963490
27CDK191.55204889
28FGFR41.50304698
29NEK61.48293461
30ERN11.46937825
31CLK11.45614581
32LMTK21.45485026
33PNCK1.44073101
34CAMK2B1.43808769
35TYRO31.40616028
36DAPK21.39087314
37OBSCN1.36277587
38ROCK21.35823992
39EPHA31.34617981
40TNIK1.33021260
41PRKCG1.29408874
42CSNK1G11.25367317
43PRKACG1.23219782
44CSNK1G21.18101651
45MST41.16648421
46CAMK2D1.14620163
47CASK1.13654974
48MAPK151.11371488
49FGR1.09197966
50MOS1.08691991
51SGK11.02727016
52CAMKK11.02501355
53MUSK0.96630520
54MAP2K20.94222644
55PRPF4B0.93594825
56DYRK20.92334578
57MAPK70.92002624
58CAMK2G0.89963928
59MAP3K90.88259113
60PAK60.88241965
61FGFR30.84526304
62ICK0.81739477
63PIM20.80931032
64IRAK20.80251668
65PHKG10.77880353
66PHKG20.77880353
67PRKD10.77589372
68CAMK1G0.77223370
69MARK10.74942935
70PRKAA20.73021103
71PRKCQ0.72566786
72PRKD30.71588105
73ERBB20.71367318
74MARK20.70444728
75GSK3A0.69833429
76PDPK10.69091011
77CAMK2A0.68285327
78RPS6KA30.68118687
79CDK50.68026038
80PRKCZ0.67827288
81MINK10.67658685
82CDK140.66555829
83PAK30.65020815
84FES0.64770480
85BMPR1B0.64415566
86JAK10.64347710
87PRKCE0.64044558
88BCKDK0.62496591
89TNK20.62062211
90GRK70.61673065
91PRKAA10.60701400
92ABL20.60407417
93MAP3K130.59049885
94BLK0.58469231
95RPS6KA50.58399601
96MAPK110.57967678
97DYRK1B0.57762987
98CAMKK20.55202166
99CDK150.55191788
100ACVR1B0.55037897
101MAP2K40.54739576
102JAK20.54512482
103TBK10.53366258
104TRPM70.53193120
105PRKCA0.53111830
106FYN0.52809539
107EPHA40.52619445
108MAPK130.52555312
109KSR20.51431803
110MAP3K10.51377784
111PIK3CA0.51197950
112MAP3K120.51189324
113MAPK100.50956028
114IGF1R0.49918661
115CDK180.49413890
116CDK11A0.49009143
117PRKACB0.48517026
118ROCK10.47442971
119FER0.46369712
120BMPR20.45892656
121PINK10.45566998
122RET0.45491286
123MAPK40.44202657
124PRKCB0.43898381
125MAP3K20.43804512
126CAMK40.43537823
127IRAK10.42797269
128PRKG10.41196007
129MAP3K50.41171614
130PTK2B0.40972267
131CSNK1A10.40020184
132ADRBK20.37892564
133CSNK1D0.37591866
134MKNK10.36840395
135PDK10.36383634
136DMPK0.35976547
137PDGFRB0.35185280
138NTRK20.34228931
139PRKCH0.33250867
140PAK20.33184420
141ITK0.32134198
142PAK10.29644638
143DAPK30.28314482
144GRK10.28054004
145DYRK1A0.27650288
146PRKACA0.27449788
147PDK20.26985567
148INSR0.25730838
149CAMK1D0.23815444
150ARAF0.23511149
151MAPK120.22496689
152CSK0.22303845

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.98958848
2Steroid biosynthesis_Homo sapiens_hsa001004.47891545
3Fatty acid elongation_Homo sapiens_hsa000624.36980769
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.96260774
5Caffeine metabolism_Homo sapiens_hsa002323.71431308
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.66653802
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.55090439
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37709635
9Complement and coagulation cascades_Homo sapiens_hsa046103.23246381
10Retinol metabolism_Homo sapiens_hsa008303.09496353
11Ether lipid metabolism_Homo sapiens_hsa005653.00237955
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91406665
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.76219665
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59530552
15Nitrogen metabolism_Homo sapiens_hsa009102.46775142
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.38199619
17Fatty acid degradation_Homo sapiens_hsa000712.30802890
18Arginine biosynthesis_Homo sapiens_hsa002202.27022899
19Sulfur metabolism_Homo sapiens_hsa009202.21080336
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17420887
21Phenylalanine metabolism_Homo sapiens_hsa003602.08557712
22Protein export_Homo sapiens_hsa030602.01460957
23Histidine metabolism_Homo sapiens_hsa003401.97020855
24Vitamin B6 metabolism_Homo sapiens_hsa007501.90259901
25Tryptophan metabolism_Homo sapiens_hsa003801.81627026
26Sphingolipid metabolism_Homo sapiens_hsa006001.76514503
27Butanoate metabolism_Homo sapiens_hsa006501.71920757
28Tyrosine metabolism_Homo sapiens_hsa003501.65862565
29Starch and sucrose metabolism_Homo sapiens_hsa005001.63137040
30Linoleic acid metabolism_Homo sapiens_hsa005911.58559911
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57817139
32PPAR signaling pathway_Homo sapiens_hsa033201.56768953
33Oxidative phosphorylation_Homo sapiens_hsa001901.53344803
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46147443
35Pancreatic secretion_Homo sapiens_hsa049721.36495443
36Propanoate metabolism_Homo sapiens_hsa006401.31354747
37Vitamin digestion and absorption_Homo sapiens_hsa049771.30761270
38Axon guidance_Homo sapiens_hsa043601.28099620
39* Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19076563
40Lysosome_Homo sapiens_hsa041421.18058103
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14165977
42Parkinsons disease_Homo sapiens_hsa050121.13472511
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11514516
44Glutathione metabolism_Homo sapiens_hsa004801.10868102
45Fatty acid metabolism_Homo sapiens_hsa012121.08335791
46Arachidonic acid metabolism_Homo sapiens_hsa005901.06146090
47Alzheimers disease_Homo sapiens_hsa050101.04941362
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.01020388
49Folate biosynthesis_Homo sapiens_hsa007901.00960087
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99700761
51Staphylococcus aureus infection_Homo sapiens_hsa051500.98564214
52Carbon metabolism_Homo sapiens_hsa012000.98259198
53Mineral absorption_Homo sapiens_hsa049780.97584573
54Collecting duct acid secretion_Homo sapiens_hsa049660.97555840
55* Arginine and proline metabolism_Homo sapiens_hsa003300.93648687
56Biosynthesis of amino acids_Homo sapiens_hsa012300.93272216
57GABAergic synapse_Homo sapiens_hsa047270.93100253
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91357130
59Glutamatergic synapse_Homo sapiens_hsa047240.88852852
60Protein digestion and absorption_Homo sapiens_hsa049740.87478904
61Serotonergic synapse_Homo sapiens_hsa047260.86867431
62Peroxisome_Homo sapiens_hsa041460.86456444
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85255539
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82031722
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81178132
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80880775
67Vibrio cholerae infection_Homo sapiens_hsa051100.79506072
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.79277830
69Renal cell carcinoma_Homo sapiens_hsa052110.79255929
70Long-term depression_Homo sapiens_hsa047300.72644656
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70279552
72ABC transporters_Homo sapiens_hsa020100.70153438
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68140676
74Cocaine addiction_Homo sapiens_hsa050300.66373538
75Other glycan degradation_Homo sapiens_hsa005110.66250430
76Pyruvate metabolism_Homo sapiens_hsa006200.65690334
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.65356456
78Phagosome_Homo sapiens_hsa041450.64383694
79Gastric acid secretion_Homo sapiens_hsa049710.64228015
80Tight junction_Homo sapiens_hsa045300.64168577
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62825549
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62062599
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.62039381
84Morphine addiction_Homo sapiens_hsa050320.61868255
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.61474434
86Glycerolipid metabolism_Homo sapiens_hsa005610.60591942
87beta-Alanine metabolism_Homo sapiens_hsa004100.59931280
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.59518699
89Ovarian steroidogenesis_Homo sapiens_hsa049130.58512001
90Endocytosis_Homo sapiens_hsa041440.57748525
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57261561
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57244320
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56456750
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56196203
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53380638
96Dorso-ventral axis formation_Homo sapiens_hsa043200.53150496
97Rheumatoid arthritis_Homo sapiens_hsa053230.53017761
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52845676
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.52331091
100Lysine degradation_Homo sapiens_hsa003100.50507023
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50364886
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.50299829
103Ras signaling pathway_Homo sapiens_hsa040140.49443500
104Salivary secretion_Homo sapiens_hsa049700.48851763
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47505655
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46186616
107* Metabolic pathways_Homo sapiens_hsa011000.43808555
108Cardiac muscle contraction_Homo sapiens_hsa042600.43223895
109Fat digestion and absorption_Homo sapiens_hsa049750.42648821
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41822088
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40044685
112Prion diseases_Homo sapiens_hsa050200.38430295
113Fatty acid biosynthesis_Homo sapiens_hsa000610.34216576
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33161508
115Huntingtons disease_Homo sapiens_hsa050160.32925344
116Circadian entrainment_Homo sapiens_hsa047130.32917155
117Chemical carcinogenesis_Homo sapiens_hsa052040.31941290
118Fructose and mannose metabolism_Homo sapiens_hsa000510.31779496
119Renin secretion_Homo sapiens_hsa049240.31457767
120Choline metabolism in cancer_Homo sapiens_hsa052310.31367698
121Cholinergic synapse_Homo sapiens_hsa047250.31305773
122Bile secretion_Homo sapiens_hsa049760.30533591
123Autoimmune thyroid disease_Homo sapiens_hsa053200.29190123
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28802118
125ECM-receptor interaction_Homo sapiens_hsa045120.28736506
126Gap junction_Homo sapiens_hsa045400.28263800
127Renin-angiotensin system_Homo sapiens_hsa046140.25868320
128Sulfur relay system_Homo sapiens_hsa041220.24793239
129Dopaminergic synapse_Homo sapiens_hsa047280.24393160
130Synaptic vesicle cycle_Homo sapiens_hsa047210.23992485
131Hedgehog signaling pathway_Homo sapiens_hsa043400.22931574
132Pentose phosphate pathway_Homo sapiens_hsa000300.19711347
133Pertussis_Homo sapiens_hsa051330.18888529
134Glucagon signaling pathway_Homo sapiens_hsa049220.16185110
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.14891537
136Galactose metabolism_Homo sapiens_hsa000520.13129338
137Insulin resistance_Homo sapiens_hsa049310.05362702
138Circadian rhythm_Homo sapiens_hsa047100.05107227
139Amphetamine addiction_Homo sapiens_hsa050310.04245075
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03596179
141Insulin secretion_Homo sapiens_hsa049110.03040883
142One carbon pool by folate_Homo sapiens_hsa006700.02013768
143Thyroid hormone synthesis_Homo sapiens_hsa049180.00346856
144Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0533727
145AMPK signaling pathway_Homo sapiens_hsa04152-0.0381464

Most similar genes based on co-expression Upload to Enrichr

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