GBA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.27119725
2positive regulation by symbiont of host defense response (GO:0052509)4.84400384
3modulation by symbiont of host defense response (GO:0052031)4.84400384
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.84400384
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.84400384
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.84400384
7modulation by symbiont of host immune response (GO:0052553)4.84400384
8oligosaccharide catabolic process (GO:0009313)4.39127568
9respiratory burst (GO:0045730)4.29130408
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22294681
11regulation of interferon-beta biosynthetic process (GO:0045357)3.93431303
12barbed-end actin filament capping (GO:0051016)3.92231225
13protein localization to endosome (GO:0036010)3.78910002
14macrophage activation involved in immune response (GO:0002281)3.78502785
15response to peptidoglycan (GO:0032494)3.73656546
16antigen processing and presentation of endogenous antigen (GO:0019883)3.70138469
17* glycosphingolipid catabolic process (GO:0046479)3.67882619
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.61864096
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57012919
20positive regulation of interferon-alpha production (GO:0032727)3.51971201
21hyaluronan catabolic process (GO:0030214)3.48941559
22immunoglobulin mediated immune response (GO:0016064)3.48650444
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46558409
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46558409
25signal peptide processing (GO:0006465)3.37610712
26protein retention in ER lumen (GO:0006621)3.35902767
27regulation of interferon-alpha production (GO:0032647)3.35023043
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32069520
29neutrophil activation (GO:0042119)3.30657467
30positive regulation of monocyte chemotaxis (GO:0090026)3.30264729
31granulocyte activation (GO:0036230)3.29817071
32endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.27441704
33positive regulation of antigen processing and presentation (GO:0002579)3.26739477
34* glycolipid catabolic process (GO:0019377)3.22663384
35apoptotic cell clearance (GO:0043277)3.21429348
36myeloid cell activation involved in immune response (GO:0002275)3.17922615
37production of molecular mediator involved in inflammatory response (GO:0002532)3.14685574
38pinocytosis (GO:0006907)3.11410019
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10088877
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09053674
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06355292
42regulation of antigen processing and presentation (GO:0002577)3.06010284
43adhesion of symbiont to host (GO:0044406)3.04514257
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03836435
45protein maturation by protein folding (GO:0022417)3.02658905
46microglial cell activation (GO:0001774)3.02200888
47amyloid precursor protein catabolic process (GO:0042987)3.01671465
48cellular response to thyroid hormone stimulus (GO:0097067)2.98340053
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97180762
50response to host immune response (GO:0052572)2.97180762
51cell adhesion mediated by integrin (GO:0033627)2.94890960
52positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94619595
53positive regulation of mast cell activation (GO:0033005)2.93139577
54regulation of mast cell degranulation (GO:0043304)2.90993748
55regulation of monocyte chemotaxis (GO:0090025)2.89465578
56hydrogen peroxide biosynthetic process (GO:0050665)2.87920415
57negative regulation of mast cell activation (GO:0033004)2.86984895
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86187922
59reactive oxygen species biosynthetic process (GO:1903409)2.85793254
60leukocyte aggregation (GO:0070486)2.85298320
61N-acetylneuraminate metabolic process (GO:0006054)2.84875668
62regulation of mononuclear cell migration (GO:0071675)2.83452958
63response to muramyl dipeptide (GO:0032495)2.81762685
64regulation of superoxide anion generation (GO:0032928)2.80550352
65positive regulation of leukocyte degranulation (GO:0043302)2.80492467
66membrane raft organization (GO:0031579)2.79151296
67* membrane lipid catabolic process (GO:0046466)2.78910938
68leukocyte migration involved in inflammatory response (GO:0002523)2.77438723
69* sphingolipid catabolic process (GO:0030149)2.77413118
70regulation of mast cell activation (GO:0033003)2.76681908
71* ceramide catabolic process (GO:0046514)2.76661844
72basement membrane organization (GO:0071711)2.76482720
73decidualization (GO:0046697)2.75824271
74cellular response to interferon-beta (GO:0035458)2.74926991
75macrophage activation (GO:0042116)2.73899674
76regulation of B cell receptor signaling pathway (GO:0050855)2.73362073
77regulation of mast cell activation involved in immune response (GO:0033006)2.72759497
78regulation of early endosome to late endosome transport (GO:2000641)2.72319698
79virion attachment to host cell (GO:0019062)2.70812312
80adhesion of symbiont to host cell (GO:0044650)2.70812312
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70454902
82positive regulation of mast cell degranulation (GO:0043306)2.70182525
83positive regulation of mast cell activation involved in immune response (GO:0033008)2.70182525
84positive regulation of interferon-beta production (GO:0032728)2.68788829
85mannose metabolic process (GO:0006013)2.68613099
86neutrophil mediated immunity (GO:0002446)2.65467330
87regulation of extracellular matrix disassembly (GO:0010715)2.65072153
88negative regulation of interleukin-12 production (GO:0032695)2.64089627
89regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63931732
90leukocyte mediated cytotoxicity (GO:0001909)2.63560276
91keratan sulfate catabolic process (GO:0042340)2.63532512
92superoxide anion generation (GO:0042554)2.63053150
93detection of molecule of bacterial origin (GO:0032490)2.62505507
94positive regulation of chemokine biosynthetic process (GO:0045080)2.61238088
95stress fiber assembly (GO:0043149)2.61003480
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60987908
97pyrimidine-containing compound salvage (GO:0008655)2.60897921
98pyrimidine nucleoside salvage (GO:0043097)2.60897921
99positive regulation of receptor recycling (GO:0001921)2.60019447
100response to fungus (GO:0009620)2.59868933
101myeloid cell homeostasis (GO:0002262)2.59737641
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.59375834
103transferrin transport (GO:0033572)2.59342149
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58316569
105natural killer cell mediated cytotoxicity (GO:0042267)2.57494022
106natural killer cell mediated immunity (GO:0002228)2.57494022
107negative regulation of nitric oxide biosynthetic process (GO:0045019)2.56822199
108regulation of leukocyte degranulation (GO:0043300)2.56673358
109peptide catabolic process (GO:0043171)2.56182606
110phagosome maturation (GO:0090382)2.55917878
111positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55868835
112regulation of interleukin-8 biosynthetic process (GO:0045414)2.54027825
113type B pancreatic cell proliferation (GO:0044342)2.53277611
114amyloid precursor protein metabolic process (GO:0042982)2.52602775
115COPI coating of Golgi vesicle (GO:0048205)2.51488193
116Golgi transport vesicle coating (GO:0048200)2.51488193
117actin nucleation (GO:0045010)2.51421862
118leukocyte degranulation (GO:0043299)2.51413420
119lipoxygenase pathway (GO:0019372)2.51041926
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50651003
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.50554615
122response to host (GO:0075136)2.50554615
123response to host defenses (GO:0052200)2.50554615
124positive regulation of heat generation (GO:0031652)2.49089685
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.48692958
126amino sugar catabolic process (GO:0046348)2.47097965
127regulation of lymphocyte migration (GO:2000401)2.46429587
128leukotriene metabolic process (GO:0006691)2.46011250
129positive regulation of toll-like receptor signaling pathway (GO:0034123)2.44313609
130membrane protein ectodomain proteolysis (GO:0006509)2.43808341
131regulation of T cell migration (GO:2000404)2.43598651
132myeloid leukocyte activation (GO:0002274)2.43013576
133ferric iron transport (GO:0015682)2.42762107
134trivalent inorganic cation transport (GO:0072512)2.42762107
135activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42758595
136negative regulation of protein localization to plasma membrane (GO:1903077)2.42233279
137positive regulation of tumor necrosis factor production (GO:0032760)2.42100379
138NIK/NF-kappaB signaling (GO:0038061)2.41610374
139* response to thyroid hormone (GO:0097066)2.40961748
140cellular response to arsenic-containing substance (GO:0071243)2.40940295
141regulation of integrin-mediated signaling pathway (GO:2001044)2.40587147
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.40468485
143cellular copper ion homeostasis (GO:0006878)2.40238108
144negative regulation of interleukin-17 production (GO:0032700)2.40122557
145positive regulation of B cell differentiation (GO:0045579)2.39679358
146retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39434672
147pentose-phosphate shunt (GO:0006098)2.39373723
148B cell mediated immunity (GO:0019724)2.39055619
149T cell migration (GO:0072678)2.38639347
150positive regulation of natural killer cell differentiation (GO:0032825)2.37292291
151detection of external biotic stimulus (GO:0098581)2.37154408
152glucose 6-phosphate metabolic process (GO:0051156)2.35581331
153lysosome organization (GO:0007040)2.34782114
154lytic vacuole organization (GO:0080171)2.34782114
155positive regulation of extracellular matrix organization (GO:1903055)2.32071267
156* skin morphogenesis (GO:0043589)2.31568053
157regulation of apoptotic process involved in morphogenesis (GO:1902337)2.30577461
158glucosamine-containing compound catabolic process (GO:1901072)2.29948420
159glial cell migration (GO:0008347)2.27746832
160serine transport (GO:0032329)2.27333909
161cellular response to type I interferon (GO:0071357)2.26381837
162type I interferon signaling pathway (GO:0060337)2.26381837
163positive regulation of nuclease activity (GO:0032075)2.26087051
164regulation of vitamin D biosynthetic process (GO:0060556)2.25428262
165response to progesterone (GO:0032570)2.25125603
166fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24932867
167response to type I interferon (GO:0034340)2.23558628
168negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.23505142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.49640173
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.85599675
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.58611190
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38527754
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.31779941
6* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18975758
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14574120
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05772652
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.94860353
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88225165
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.86567762
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.83503624
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81906112
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56371516
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43491930
16* SPI1_23547873_ChIP-Seq_NB4_Human2.21195825
17* LXR_22292898_ChIP-Seq_THP-1_Human2.19227601
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18017479
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10731452
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02840812
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01881143
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97795012
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97039634
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95100003
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.94572591
26* RACK7_27058665_Chip-Seq_MCF-7_Human1.94482003
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93858876
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.91414512
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89646614
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.86859762
31* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82206243
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81955349
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79962904
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75881956
35VDR_24763502_ChIP-Seq_THP-1_Human1.69510343
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.69417941
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67091036
38* TFEB_21752829_ChIP-Seq_HELA_Human1.61953179
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60524197
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60025732
41ZNF263_19887448_ChIP-Seq_K562_Human1.59126996
42VDR_21846776_ChIP-Seq_THP-1_Human1.57859572
43MYB_26560356_Chip-Seq_TH2_Human1.56649414
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56458647
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55226567
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50208093
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49840467
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.48977183
49CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45964114
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45587637
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.45371536
52* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43974699
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42576293
54PU_27001747_Chip-Seq_BMDM_Mouse1.42044953
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41238757
56MAF_26560356_Chip-Seq_TH1_Human1.40841576
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40314403
58SPI1_23127762_ChIP-Seq_K562_Human1.40301488
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39807505
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38361535
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36692251
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36525796
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34786613
64ATF3_27146783_Chip-Seq_COLON_Human1.34361837
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34003325
66GATA1_22025678_ChIP-Seq_K562_Human1.32953362
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31573897
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31195701
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30350707
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29938028
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28205144
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27850773
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27603248
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.27200861
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27052068
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26527724
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26294820
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25550510
79MYB_26560356_Chip-Seq_TH1_Human1.23028074
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22701464
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22542516
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21860832
83SOX2_20726797_ChIP-Seq_SW620_Human1.21708096
84* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21599296
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21586984
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21118829
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.17893269
88SCL_19346495_ChIP-Seq_HPC-7_Human1.17677598
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17208853
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16129088
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14194093
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14147898
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13367678
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.13355227
95GATA3_27048872_Chip-Seq_THYMUS_Human1.12634951
96RUNX_20019798_ChIP-Seq_JUKART_Human1.12233846
97* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11987865
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10791652
99VDR_24787735_ChIP-Seq_THP-1_Human1.09749384
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08094436
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07651400
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07399712
103* GATA3_26560356_Chip-Seq_TH2_Human1.07377608
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06689524
105* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05866536
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05251670
107KDM2B_26808549_Chip-Seq_DND41_Human1.03664688
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03063808
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02826920
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02003787
111BCOR_27268052_Chip-Seq_Bcells_Human1.01759588
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01711674
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01631554
114* UBF1/2_26484160_Chip-Seq_HMECs_Human1.01445352
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00527104
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.99753328
117* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99670736
118TP53_22127205_ChIP-Seq_IMR90_Human0.99591798
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98927189
120TCF7_22412390_ChIP-Seq_EML_Mouse0.98745019
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98053383
122CLOCK_20551151_ChIP-Seq_293T_Human0.98030920
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97433017
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97117392
125* UTX_26944678_Chip-Seq_JUKART_Human0.96624306
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.96018827
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95960198
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.95391242
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93516862
130CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93320685
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91909803
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91909803
133* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91588130
134* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91588130
135ELK1_22589737_ChIP-Seq_MCF10A_Human0.90604162
136MAF_26560356_Chip-Seq_TH2_Human0.88914999
137PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85535394
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85396306
139* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84573081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.47399293
2MP0003436_decreased_susceptibility_to3.48535718
3MP0001835_abnormal_antigen_presentation3.33334765
4MP0002148_abnormal_hypersensitivity_rea3.04489087
5MP0008438_abnormal_cutaneous_collagen2.96663918
6MP0003172_abnormal_lysosome_physiology2.92492092
7MP0006082_CNS_inflammation2.86690542
8MP0002419_abnormal_innate_immunity2.86380121
9MP0009840_abnormal_foam_cell2.75004832
10MP0005000_abnormal_immune_tolerance2.69315592
11MP0009785_altered_susceptibility_to2.59400679
12MP0003303_peritoneal_inflammation2.56245901
13MP0005025_abnormal_response_to2.35155390
14MP0003806_abnormal_nucleotide_metabolis2.32188679
15* MP0001533_abnormal_skeleton_physiology2.27316299
16MP0005387_immune_system_phenotype2.23789910
17MP0001790_abnormal_immune_system2.23789910
18MP0002452_abnormal_antigen_presenting2.18485282
19MP0000685_abnormal_immune_system2.10672202
20MP0000604_amyloidosis2.04386459
21* MP0002723_abnormal_immune_serum1.99211675
22MP0001800_abnormal_humoral_immune1.95891819
23MP0003724_increased_susceptibility_to1.91622599
24MP0004947_skin_inflammation1.91266981
25MP0003191_abnormal_cellular_cholesterol1.89928161
26MP0009333_abnormal_splenocyte_physiolog1.86660610
27MP0001819_abnormal_immune_cell1.85668724
28MP0002420_abnormal_adaptive_immunity1.85368244
29MP0005464_abnormal_platelet_physiology1.84339408
30MP0002933_joint_inflammation1.84001819
31* MP0005671_abnormal_response_to1.80979465
32MP0005451_abnormal_body_composition1.77780126
33MP0005310_abnormal_salivary_gland1.76169177
34MP0002405_respiratory_system_inflammati1.65518212
35MP0003448_altered_tumor_morphology1.65059075
36MP0003690_abnormal_glial_cell1.62563302
37MP0001845_abnormal_inflammatory_respons1.62271365
38MP0002998_abnormal_bone_remodeling1.61461250
39MP0000343_altered_response_to1.58797172
40MP0003183_abnormal_peptide_metabolism1.58359089
41MP0001958_emphysema1.57205864
42MP0001542_abnormal_bone_strength1.54557425
43MP0002877_abnormal_melanocyte_morpholog1.51260805
44MP0001853_heart_inflammation1.46002355
45MP0005275_abnormal_skin_tensile1.44431844
46MP0010234_abnormal_vibrissa_follicle1.43175515
47MP0000920_abnormal_myelination1.43055466
48* MP0008469_abnormal_protein_level1.41933308
49MP0006054_spinal_hemorrhage1.41839688
50MP0004272_abnormal_basement_membrane1.41131436
51MP0002139_abnormal_hepatobiliary_system1.39912787
52MP0003300_gastrointestinal_ulcer1.39328601
53MP0003566_abnormal_cell_adhesion1.38373911
54MP0000858_altered_metastatic_potential1.36913143
55* MP0005390_skeleton_phenotype1.36049617
56MP0004510_myositis1.33190682
57MP0000465_gastrointestinal_hemorrhage1.28665737
58MP0003075_altered_response_to1.28151320
59* MP0000716_abnormal_immune_system1.27088178
60MP0005408_hypopigmentation1.22922901
61MP0003950_abnormal_plasma_membrane1.22867948
62MP0004233_abnormal_muscle_weight1.22347855
63MP0001851_eye_inflammation1.22243384
64MP0000015_abnormal_ear_pigmentation1.22084479
65MP0005164_abnormal_response_to1.22059771
66MP0005023_abnormal_wound_healing1.21329728
67MP0010155_abnormal_intestine_physiology1.21093277
68MP0000371_diluted_coat_color1.17301951
69MP0003195_calcinosis1.17212026
70MP0005165_increased_susceptibility_to1.16040477
71MP0009764_decreased_sensitivity_to1.14966617
72MP0001849_ear_inflammation1.14542650
73MP0003705_abnormal_hypodermis_morpholog1.12688569
74MP0004858_abnormal_nervous_system1.10908280
75MP0002254_reproductive_system_inflammat1.10597891
76* MP0003795_abnormal_bone_structure1.10143328
77* MP0002398_abnormal_bone_marrow1.09854881
78MP0003329_amyloid_beta_deposits1.09484067
79MP0002166_altered_tumor_susceptibility1.08497587
80* MP0000689_abnormal_spleen_morphology1.08113275
81MP0003186_abnormal_redox_activity1.06110028
82* MP0002429_abnormal_blood_cell1.05095559
83MP0002896_abnormal_bone_mineralization1.03208937
84MP0002006_tumorigenesis1.02932648
85MP0003453_abnormal_keratinocyte_physiol1.02089341
86MP0005365_abnormal_bile_salt0.98985202
87MP0005257_abnormal_intraocular_pressure0.97764263
88* MP0002722_abnormal_immune_system0.96881189
89MP0003279_aneurysm0.93944938
90MP0003091_abnormal_cell_migration0.93535013
91MP0001243_abnormal_dermal_layer0.93248426
92MP0008260_abnormal_autophagy0.90779566
93MP0008004_abnormal_stomach_pH0.89303125
94MP0003656_abnormal_erythrocyte_physiolo0.89073918
95MP0000681_abnormal_thyroid_gland0.87987639
96MP0005171_absent_coat_pigmentation0.86372937
97MP0009384_cardiac_valve_regurgitation0.84854783
98MP0003828_pulmonary_edema0.84008533
99MP0010352_gastrointestinal_tract_polyps0.83434237
100MP0002060_abnormal_skin_morphology0.82153401
101MP0000767_abnormal_smooth_muscle0.81315526
102MP0000249_abnormal_blood_vessel0.77089695
103MP0005508_abnormal_skeleton_morphology0.75751042
104MP0010386_abnormal_urinary_bladder0.75435765
105MP0005503_abnormal_tendon_morphology0.74610034
106MP0005623_abnormal_meninges_morphology0.74474918
107MP0004883_abnormal_blood_vessel0.73772861
108MP0005166_decreased_susceptibility_to0.73610130
109MP0005174_abnormal_tail_pigmentation0.72448183
110* MP0002295_abnormal_pulmonary_circulatio0.71590324
111MP0009763_increased_sensitivity_to0.71465915
112MP0001873_stomach_inflammation0.71275492
113* MP0005319_abnormal_enzyme/_coenzyme0.70847179
114MP0004782_abnormal_surfactant_physiolog0.70113501
115MP0002796_impaired_skin_barrier0.69061083
116* MP0001216_abnormal_epidermal_layer0.68497158
117* MP0003634_abnormal_glial_cell0.68189791
118MP0002136_abnormal_kidney_physiology0.68061484
119MP0000490_abnormal_crypts_of0.66891528
120MP0009643_abnormal_urine_homeostasis0.66588098
121MP0010307_abnormal_tumor_latency0.66481685
122MP0009278_abnormal_bone_marrow0.65580703
123MP0001545_abnormal_hematopoietic_system0.64273148
124MP0005397_hematopoietic_system_phenotyp0.64273148
125MP0005595_abnormal_vascular_smooth0.63335832
126MP0000372_irregular_coat_pigmentation0.62879594

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.85847545
2Vacuolated lymphocytes (HP:0001922)5.52530252
3Recurrent bacterial skin infections (HP:0005406)5.24413185
4Increased cerebral lipofuscin (HP:0011813)5.22514085
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.96777121
6Eczematoid dermatitis (HP:0000976)4.96336817
7Dysostosis multiplex (HP:0000943)4.95372461
8Abnormality of macrophages (HP:0004311)4.48545842
9Recurrent gram-negative bacterial infections (HP:0005420)3.96809104
10Systemic lupus erythematosus (HP:0002725)3.88468004
11Urinary glycosaminoglycan excretion (HP:0003541)3.81002658
12Mucopolysacchariduria (HP:0008155)3.81002658
13Nuclear cataract (HP:0100018)3.68331773
14* Abnormality of glycolipid metabolism (HP:0010969)3.48772150
15* Abnormality of liposaccharide metabolism (HP:0010968)3.48772150
16* Abnormality of glycosphingolipid metabolism (HP:0004343)3.48772150
17Abnormality of polysaccharide metabolism (HP:0011012)3.46944202
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.46944202
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.46944202
20Recurrent skin infections (HP:0001581)3.41656073
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.37097879
22Premature rupture of membranes (HP:0001788)3.28155626
23Elevated erythrocyte sedimentation rate (HP:0003565)3.21194242
24Obstructive lung disease (HP:0006536)3.02890443
25Chronic obstructive pulmonary disease (HP:0006510)3.02890443
26Axonal loss (HP:0003447)2.93797535
27Cervical subluxation (HP:0003308)2.91603036
28Osteolytic defects of the hand bones (HP:0009699)2.88029832
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.88029832
30Gingivitis (HP:0000230)2.84421800
31Hepatosplenomegaly (HP:0001433)2.81730783
32Loss of speech (HP:0002371)2.78886895
33Stomatitis (HP:0010280)2.75949005
34Neurofibrillary tangles (HP:0002185)2.75717295
35Pustule (HP:0200039)2.72420251
36Mediastinal lymphadenopathy (HP:0100721)2.63460065
37Basal ganglia calcification (HP:0002135)2.58822192
38Recurrent fungal infections (HP:0002841)2.56744237
39Disinhibition (HP:0000734)2.55886794
40* Vertebral compression fractures (HP:0002953)2.49391063
41Parakeratosis (HP:0001036)2.47560851
42Myositis (HP:0100614)2.47221792
43Poor head control (HP:0002421)2.41978228
44Recurrent viral infections (HP:0004429)2.41406804
45Urticaria (HP:0001025)2.40473947
46Cellulitis (HP:0100658)2.37305761
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37253648
48Glomerulonephritis (HP:0000099)2.36621668
49Beaking of vertebral bodies (HP:0004568)2.34930086
50Abnormality of the lumbar spine (HP:0100712)2.32775277
51Chronic otitis media (HP:0000389)2.30986676
52Distal lower limb muscle weakness (HP:0009053)2.29223615
53Prolonged neonatal jaundice (HP:0006579)2.28393410
54Amyloidosis (HP:0011034)2.28118950
55Autoimmune thrombocytopenia (HP:0001973)2.27143744
56Periodontitis (HP:0000704)2.26519034
57Thick nail (HP:0001805)2.25734317
58Spondylolisthesis (HP:0003302)2.25651673
59Short nail (HP:0001799)2.24666928
60* Progressive neurologic deterioration (HP:0002344)2.24271146
61Ankle contracture (HP:0006466)2.23130471
62Upper motor neuron abnormality (HP:0002127)2.21453856
63Epiphyseal dysplasia (HP:0002656)2.20547458
64Joint stiffness (HP:0001387)2.20366038
65Abnormality of the distal phalanges of the toes (HP:0010182)2.20311035
66Ovoid vertebral bodies (HP:0003300)2.14106713
67* Cardiomegaly (HP:0001640)2.13900641
68Peritonitis (HP:0002586)2.13234226
69Osteomyelitis (HP:0002754)2.12712642
70Myocardial infarction (HP:0001658)2.12025787
71Achilles tendon contracture (HP:0001771)2.10861917
72* Petechiae (HP:0000967)2.08991741
73Recurrent pneumonia (HP:0006532)2.06886134
74* Interstitial pulmonary disease (HP:0006530)2.03323297
75Cerebral aneurysm (HP:0004944)2.00934638
76Upper limb amyotrophy (HP:0009129)2.00254216
77Distal upper limb amyotrophy (HP:0007149)2.00254216
78Asymmetric septal hypertrophy (HP:0001670)1.99928663
79Vasculitis (HP:0002633)1.96951858
80* Purpura (HP:0000979)1.96833875
81Small epiphyses (HP:0010585)1.96671819
82Abnormality of the Achilles tendon (HP:0005109)1.95678723
83Abnormality of complement system (HP:0005339)1.95590492
84Emphysema (HP:0002097)1.95161747
85Hypoplasia of the odontoid process (HP:0003311)1.94710392
86* Bone pain (HP:0002653)1.94650865
87Tetraparesis (HP:0002273)1.92979640
88Leukocytosis (HP:0001974)1.92858554
89Increased IgE level (HP:0003212)1.91772023
90Personality changes (HP:0000751)1.91519663
91Blue sclerae (HP:0000592)1.89341797
92Thoracic kyphosis (HP:0002942)1.89051085
93Neuronal loss in central nervous system (HP:0002529)1.87541809
94Orchitis (HP:0100796)1.85842452
95J-shaped sella turcica (HP:0002680)1.85123818
96Elbow flexion contracture (HP:0002987)1.83864375
97* Pathologic fracture (HP:0002756)1.82902135
98Mutism (HP:0002300)1.82712295
99Eosinophilia (HP:0001880)1.82035916
100Recurrent lower respiratory tract infections (HP:0002783)1.81267808
101Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79730441
102* Hypergammaglobulinemia (HP:0010702)1.78206754
103Cerebral inclusion bodies (HP:0100314)1.76884082
104Abnormality of the odontoid process (HP:0003310)1.76543317
105Neoplasm of head and neck (HP:0012288)1.76154408
106Esophageal neoplasm (HP:0100751)1.76154408
107Increased connective tissue (HP:0009025)1.75444363
108Cupped ribs (HP:0000887)1.75074166
109* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74842246
110Segmental peripheral demyelination/remyelination (HP:0003481)1.74317992
111Premature loss of primary teeth (HP:0006323)1.73420633
112Abnormality of the umbilical cord (HP:0010881)1.72856541
113Hand muscle atrophy (HP:0009130)1.72527774
114Chronic mucocutaneous candidiasis (HP:0002728)1.72350289
115Recurrent cutaneous fungal infections (HP:0011370)1.72350289
116Dilatation of the ascending aorta (HP:0005111)1.71616676
117Distal lower limb amyotrophy (HP:0008944)1.70998694
118Follicular hyperkeratosis (HP:0007502)1.70625138
119Meningitis (HP:0001287)1.68701718
120Ocular albinism (HP:0001107)1.67578976
121Atrophic scars (HP:0001075)1.67560099
122Skin ulcer (HP:0200042)1.67111352
123Xanthomatosis (HP:0000991)1.66756786
124Vascular tortuosity (HP:0004948)1.66295899
125Rough bone trabeculation (HP:0100670)1.65686822
126Fragile skin (HP:0001030)1.65526179
127Complement deficiency (HP:0004431)1.65458878
128Wormian bones (HP:0002645)1.64324565
129* Congenital ichthyosiform erythroderma (HP:0007431)1.64259098
130Agnosia (HP:0010524)1.63974946
131Hyperacusis (HP:0010780)1.63599576
132Coxa vara (HP:0002812)1.63257603
133Anhidrosis (HP:0000970)1.63138205
134Protrusio acetabuli (HP:0003179)1.62563566
135Generalized amyotrophy (HP:0003700)1.61929450
136Bladder diverticulum (HP:0000015)1.61905180
137Increased serum ferritin (HP:0003281)1.61652896
138Reduced subcutaneous adipose tissue (HP:0003758)1.60995451
139* Diminished motivation (HP:0000745)1.60278217
140Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59230599
141Abnormality of the acetabulum (HP:0003170)1.57796435
142Genu recurvatum (HP:0002816)1.57548994
143Aneurysm (HP:0002617)1.57390205
144Aortic dissection (HP:0002647)1.57067032
145* Apathy (HP:0000741)1.56681588
146Deformed sella turcica (HP:0002681)1.56184802
147Thin bony cortex (HP:0002753)1.55763676
148Zonular cataract (HP:0010920)1.55575802
149Hyperparathyroidism (HP:0000843)1.55522907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.29885842
2IRAK43.26960607
3ERN13.25212945
4MAP3K143.12696805
5IRAK32.99368887
6TYK22.79608201
7TBK12.78662098
8EPHB12.63369622
9NME22.62298116
10PIM22.45604356
11KIT2.35908825
12MAP4K12.29334878
13PBK2.20507164
14MST41.95769879
15TAOK21.85126306
16IKBKB1.80989428
17SIK11.80095916
18ZAP701.79790706
19TESK21.68988447
20IKBKE1.65481790
21RIPK41.54822463
22MYLK1.51366295
23PRPF4B1.50407172
24RIPK11.49324072
25MAP3K121.46370587
26PTK21.45539481
27NEK91.44425453
28LRRK21.41192974
29STK101.41120722
30JAK11.40394386
31CSF1R1.38068686
32PRKD21.36617475
33JAK31.35884890
34CSK1.35707942
35PDGFRA1.35585491
36EIF2AK31.33750404
37MET1.33331972
38TRPM71.30487824
39TAOK11.28233111
40GRK71.26302320
41TXK1.26120985
42MST1R1.22113031
43SMG11.19159213
44HCK1.18121561
45BTK1.16409418
46CDC42BPA1.14612126
47ARAF1.13627951
48TAOK31.13509775
49SIK31.13368389
50TGFBR21.12409877
51SYK1.11495744
52MAP3K131.09522729
53ITK1.09285207
54MAP3K11.08690523
55ABL21.08395712
56LYN1.08293353
57EIF2AK11.07560930
58PAK41.07450602
59MAPKAPK31.04537632
60SCYL21.04051219
61PIK3CG1.04006438
62BMX1.00730718
63ICK1.00600038
64TEC1.00116864
65LCK0.97749023
66TESK10.97082549
67IRAK10.93736059
68MAPKAPK50.93021222
69NTRK10.92443302
70STK380.87026915
71RPS6KA40.86305083
72MAP3K30.85708064
73EPHA30.85010072
74TRIB30.83834974
75FGFR40.82020642
76LMTK20.80056646
77MAP3K20.78694346
78TTN0.77358621
79DDR20.76936560
80FES0.76162025
81CHUK0.74810037
82FGR0.73537131
83PDPK10.72799094
84CLK10.71297744
85PIM10.69722476
86JAK20.69493507
87MAP2K20.68869511
88EPHA20.68498993
89EPHB20.66513076
90PRKCD0.65694264
91LIMK10.65190535
92MAPKAPK20.62914933
93PRKCQ0.60732219
94MOS0.60268193
95RPS6KA20.58549875
96MAP2K30.58423538
97PKN20.58265691
98ABL10.58004496
99PTK60.55311986
100MATK0.55219241
101MAP3K110.54911248
102KDR0.54707836
103KSR20.53349056
104MAP3K60.53092784
105FER0.51850066
106MAP3K80.51506204
107STK160.51498105
108EGFR0.51013597
109MARK30.49748606
110MAPK150.49286772
111FLT30.48861774
112PAK10.44839068
113PDGFRB0.43834506
114LATS20.43644374
115CAMKK20.42792129
116DAPK30.42454916
117BMPR1B0.40883878
118RPS6KA50.40756944
119PAK60.39905347
120STK390.39171554
121CAMK2G0.37590922
122MAPK110.37508218
123DAPK10.36529741
124MAP2K60.36002126
125ERBB30.34731802
126GSK3A0.33833585
127TNIK0.33135076
128IRAK20.32688958
129GRK60.31258576
130STK40.31054928
131PRKG20.30291631
132FYN0.30188699
133PAK20.29957044
134STK240.28045502
135EIF2AK20.27807723
136MAPK40.27216586
137ILK0.26940362

Predicted pathways (KEGG)

RankGene SetZ-score
1* Lysosome_Homo sapiens_hsa041423.56791617
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.95456226
3* Other glycan degradation_Homo sapiens_hsa005112.70781518
4Staphylococcus aureus infection_Homo sapiens_hsa051502.69962152
5Leishmaniasis_Homo sapiens_hsa051402.67555790
6Phagosome_Homo sapiens_hsa041452.23342021
7Malaria_Homo sapiens_hsa051442.21872802
8Rheumatoid arthritis_Homo sapiens_hsa053232.11802076
9Steroid biosynthesis_Homo sapiens_hsa001002.05360588
10Protein export_Homo sapiens_hsa030601.99688949
11Osteoclast differentiation_Homo sapiens_hsa043801.96066597
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95744443
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89765608
14Pertussis_Homo sapiens_hsa051331.87569887
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.86446197
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86203750
17Tuberculosis_Homo sapiens_hsa051521.85819079
18Antigen processing and presentation_Homo sapiens_hsa046121.85054204
19Legionellosis_Homo sapiens_hsa051341.82612697
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78021054
21Proteasome_Homo sapiens_hsa030501.75374713
22* Sphingolipid metabolism_Homo sapiens_hsa006001.61715423
23Asthma_Homo sapiens_hsa053101.51673484
24Sulfur metabolism_Homo sapiens_hsa009201.49139548
25Graft-versus-host disease_Homo sapiens_hsa053321.45864441
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45020910
27Measles_Homo sapiens_hsa051621.44497711
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44115708
29Bladder cancer_Homo sapiens_hsa052191.43921192
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.42707349
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42565002
32Apoptosis_Homo sapiens_hsa042101.37968260
33Hematopoietic cell lineage_Homo sapiens_hsa046401.37432705
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35658259
35Allograft rejection_Homo sapiens_hsa053301.33550905
36Fructose and mannose metabolism_Homo sapiens_hsa000511.29754499
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27688133
38B cell receptor signaling pathway_Homo sapiens_hsa046621.27611651
39Shigellosis_Homo sapiens_hsa051311.23194339
40Toxoplasmosis_Homo sapiens_hsa051451.22935762
41Salmonella infection_Homo sapiens_hsa051321.20619731
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16979323
43Renin-angiotensin system_Homo sapiens_hsa046141.16782243
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15373369
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13882001
46Vibrio cholerae infection_Homo sapiens_hsa051101.11421833
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04190112
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.01719588
49TNF signaling pathway_Homo sapiens_hsa046681.01682638
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00138848
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99418049
52Influenza A_Homo sapiens_hsa051640.95883752
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95755756
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95255896
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92022212
56Arachidonic acid metabolism_Homo sapiens_hsa005900.90546847
57Ether lipid metabolism_Homo sapiens_hsa005650.89950643
58Collecting duct acid secretion_Homo sapiens_hsa049660.88853480
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86096742
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84167325
61Primary immunodeficiency_Homo sapiens_hsa053400.82208292
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.81207793
63Complement and coagulation cascades_Homo sapiens_hsa046100.80128022
64Hepatitis B_Homo sapiens_hsa051610.77069313
65Folate biosynthesis_Homo sapiens_hsa007900.76928856
66N-Glycan biosynthesis_Homo sapiens_hsa005100.76483702
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74835933
68Amoebiasis_Homo sapiens_hsa051460.73619315
69Caffeine metabolism_Homo sapiens_hsa002320.72746340
70Hepatitis C_Homo sapiens_hsa051600.72146862
71Chemokine signaling pathway_Homo sapiens_hsa040620.72122460
72Herpes simplex infection_Homo sapiens_hsa051680.71014359
73Autoimmune thyroid disease_Homo sapiens_hsa053200.69972463
74Synaptic vesicle cycle_Homo sapiens_hsa047210.69251187
75Focal adhesion_Homo sapiens_hsa045100.68311777
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68029503
77Endocytosis_Homo sapiens_hsa041440.66427774
78Epstein-Barr virus infection_Homo sapiens_hsa051690.65304999
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.63670564
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61608860
81ECM-receptor interaction_Homo sapiens_hsa045120.60343964
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59846057
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59048439
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.58757908
85Fatty acid elongation_Homo sapiens_hsa000620.57673439
86Histidine metabolism_Homo sapiens_hsa003400.55225450
87Pancreatic cancer_Homo sapiens_hsa052120.55183249
88Viral myocarditis_Homo sapiens_hsa054160.54640946
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.54253001
90African trypanosomiasis_Homo sapiens_hsa051430.52964640
91Prion diseases_Homo sapiens_hsa050200.52247509
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.51818342
93Small cell lung cancer_Homo sapiens_hsa052220.51626842
94T cell receptor signaling pathway_Homo sapiens_hsa046600.51610733
95PPAR signaling pathway_Homo sapiens_hsa033200.51270993
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50794330
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50708240
98Chronic myeloid leukemia_Homo sapiens_hsa052200.50476788
99p53 signaling pathway_Homo sapiens_hsa041150.50388099
100Acute myeloid leukemia_Homo sapiens_hsa052210.49744897
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49496955
102Type I diabetes mellitus_Homo sapiens_hsa049400.49354746
103Mineral absorption_Homo sapiens_hsa049780.49256442
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.49123080
105Pentose phosphate pathway_Homo sapiens_hsa000300.47692521
106Linoleic acid metabolism_Homo sapiens_hsa005910.46012686
107VEGF signaling pathway_Homo sapiens_hsa043700.45486498
108Galactose metabolism_Homo sapiens_hsa000520.45242166
109Viral carcinogenesis_Homo sapiens_hsa052030.44375958
110Vitamin digestion and absorption_Homo sapiens_hsa049770.44013190
111Glutathione metabolism_Homo sapiens_hsa004800.43748731
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43265714
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.43234418
114Platelet activation_Homo sapiens_hsa046110.42853477
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42564234
116Insulin resistance_Homo sapiens_hsa049310.41357121
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41326880
118Proteoglycans in cancer_Homo sapiens_hsa052050.41064971
119Renal cell carcinoma_Homo sapiens_hsa052110.39665201
120Non-small cell lung cancer_Homo sapiens_hsa052230.38131082
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37507962
122Sulfur relay system_Homo sapiens_hsa041220.35493822
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32200179
124Prolactin signaling pathway_Homo sapiens_hsa049170.31658551

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