GBA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.05528182
2epoxygenase P450 pathway (GO:0019373)8.78253803
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.42484246
4fat-soluble vitamin biosynthetic process (GO:0042362)6.75820848
5exogenous drug catabolic process (GO:0042738)6.72798902
6drug catabolic process (GO:0042737)6.60977448
7cellular glucuronidation (GO:0052695)6.48594933
8lipoprotein transport (GO:0042953)6.41040985
9regulation of bile acid biosynthetic process (GO:0070857)6.40940554
10drug metabolic process (GO:0017144)6.38199650
11glucuronate metabolic process (GO:0019585)6.29727412
12uronic acid metabolic process (GO:0006063)6.29727412
13urea metabolic process (GO:0019627)6.20630305
14NADH metabolic process (GO:0006734)6.16819228
15intestinal absorption (GO:0050892)5.99119873
16urea cycle (GO:0000050)5.89751901
17hormone catabolic process (GO:0042447)5.86231549
18regulation of triglyceride catabolic process (GO:0010896)5.71266520
19nitrogen cycle metabolic process (GO:0071941)5.68443744
20omega-hydroxylase P450 pathway (GO:0097267)5.57910873
21bile acid and bile salt transport (GO:0015721)5.57317366
22regulation of guanylate cyclase activity (GO:0031282)5.53018336
23fructose metabolic process (GO:0006000)5.37500274
24very-low-density lipoprotein particle assembly (GO:0034379)4.92343154
25ethanol oxidation (GO:0006069)4.87482490
26bile acid metabolic process (GO:0008206)4.85528796
27alkaloid metabolic process (GO:0009820)4.76065052
28flavonoid metabolic process (GO:0009812)4.71145599
29regulation of systemic arterial blood pressure by hormone (GO:0001990)4.41811528
30regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.41811528
31endocrine process (GO:0050886)4.41811528
32positive regulation of guanylate cyclase activity (GO:0031284)4.29041811
33arginine metabolic process (GO:0006525)4.28789739
34phospholipid efflux (GO:0033700)4.27442060
35plasma lipoprotein particle assembly (GO:0034377)4.18894045
36diacylglycerol metabolic process (GO:0046339)4.18451056
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12324131
38virion attachment to host cell (GO:0019062)4.06298430
39adhesion of symbiont to host cell (GO:0044650)4.06298430
40phenylpropanoid metabolic process (GO:0009698)3.97748037
41lipoprotein metabolic process (GO:0042157)3.97257700
42positive regulation of triglyceride lipase activity (GO:0061365)3.93565349
43positive regulation of lipoprotein lipase activity (GO:0051006)3.93565349
44renal system process involved in regulation of blood volume (GO:0001977)3.93335456
45regulation of cholesterol esterification (GO:0010872)3.93181551
46regulation of systemic arterial blood pressure (GO:0003073)3.91140469
47ethanol metabolic process (GO:0006067)3.83840443
48protein-lipid complex assembly (GO:0065005)3.79082855
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77753900
50glutamine family amino acid biosynthetic process (GO:0009084)3.75786286
51drug transmembrane transport (GO:0006855)3.74087525
52midgut development (GO:0007494)3.73095434
53regulation of cellular extravasation (GO:0002691)3.72871893
54vitamin biosynthetic process (GO:0009110)3.72807665
55drug transport (GO:0015893)3.70630426
56high-density lipoprotein particle remodeling (GO:0034375)3.66953644
57peptide hormone processing (GO:0016486)3.64501315
58heme transport (GO:0015886)3.63978755
59positive regulation of lipid catabolic process (GO:0050996)3.61785891
60protein-lipid complex remodeling (GO:0034368)3.60942342
61macromolecular complex remodeling (GO:0034367)3.60942342
62plasma lipoprotein particle remodeling (GO:0034369)3.60942342
63fat-soluble vitamin metabolic process (GO:0006775)3.60008721
64adhesion of symbiont to host (GO:0044406)3.57694316
65oxidative demethylation (GO:0070989)3.57626559
66vitamin transport (GO:0051180)3.52088904
67negative regulation of sterol transport (GO:0032372)3.50894162
68negative regulation of cholesterol transport (GO:0032375)3.50894162
69glyoxylate metabolic process (GO:0046487)3.50413340
70cholesterol efflux (GO:0033344)3.46390401
71digestion (GO:0007586)3.46237636
72maintenance of gastrointestinal epithelium (GO:0030277)3.43349290
73cholesterol homeostasis (GO:0042632)3.40831311
74homocysteine metabolic process (GO:0050667)3.40076857
75sterol homeostasis (GO:0055092)3.34906515
76receptor guanylyl cyclase signaling pathway (GO:0007168)3.34876965
77regulation of cGMP biosynthetic process (GO:0030826)3.34093856
78urate metabolic process (GO:0046415)3.32161466
79vitamin A metabolic process (GO:0006776)3.28678366
80peptide catabolic process (GO:0043171)3.28513336
81vitamin D metabolic process (GO:0042359)3.26512939
82drinking behavior (GO:0042756)3.24997143
83complement activation, alternative pathway (GO:0006957)3.24157110
84plasma lipoprotein particle organization (GO:0071827)3.22410671
85citrulline biosynthetic process (GO:0019240)3.21523033
86renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.21497203
87reverse cholesterol transport (GO:0043691)3.19214049
88L-ascorbic acid metabolic process (GO:0019852)3.16209904
89regulation of protein activation cascade (GO:2000257)3.13241628
90proline metabolic process (GO:0006560)3.13058178
91bile acid biosynthetic process (GO:0006699)3.13021357
92vitamin transmembrane transport (GO:0035461)3.12673985
93xenobiotic metabolic process (GO:0006805)3.12461406
94regulation of cholesterol homeostasis (GO:2000188)3.12125596
95regulation of vitamin metabolic process (GO:0030656)3.09461676
96complement activation, classical pathway (GO:0006958)3.08270182
97protein-lipid complex subunit organization (GO:0071825)3.06542954
98antibacterial humoral response (GO:0019731)3.05938871
99oxaloacetate metabolic process (GO:0006107)3.05771341
100regulation of fibrinolysis (GO:0051917)3.05428607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.93220941
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.42012206
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.36059337
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.23982045
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.82743767
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.82454424
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61208486
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38946258
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.33882344
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98093532
11GATA4_25053715_ChIP-Seq_YYC3_Human2.65674098
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.59796587
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.33795930
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.28037745
15GATA6_25053715_ChIP-Seq_YYC3_Human2.17692012
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.06669354
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02247568
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01598795
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.98255541
20GATA1_22025678_ChIP-Seq_K562_Human1.97931105
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.97256442
22SOX2_20726797_ChIP-Seq_SW620_Human1.93108183
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81524277
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.79267998
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72705876
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.68838582
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66786255
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63183407
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59290106
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.49904074
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45840788
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.45389445
33PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44776353
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42307820
35CLOCK_20551151_ChIP-Seq_293T_Human1.35227109
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.30165434
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.25260548
38LXR_22292898_ChIP-Seq_THP-1_Human1.24983968
39* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23205465
40CDX2_22108803_ChIP-Seq_LS180_Human1.23104938
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18015584
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16019982
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14754474
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12419262
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.06189812
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.03573800
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02765540
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01212319
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00449165
50GATA2_19941826_ChIP-Seq_K562_Human0.99829366
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97969287
52CEBPB_22108803_ChIP-Seq_LS180_Human0.95684097
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94184167
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93122853
55AR_21909140_ChIP-Seq_LNCAP_Human0.91220706
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91029508
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90490123
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89532277
59SA1_27219007_Chip-Seq_Bcells_Human0.89364917
60KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88772206
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88524265
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86903070
63JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86218812
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85976716
65BCOR_27268052_Chip-Seq_Bcells_Human0.84653352
66BCL6_27268052_Chip-Seq_Bcells_Human0.81665626
67GATA1_19941826_ChIP-Seq_K562_Human0.81582690
68RXR_22108803_ChIP-Seq_LS180_Human0.80866219
69NANOG_20526341_ChIP-Seq_ESCs_Human0.80474374
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80356451
71ESR1_21235772_ChIP-Seq_MCF-7_Human0.80028533
72HNFA_21074721_ChIP-Seq_CACO-2_Human0.79797072
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79741587
74ESR2_21235772_ChIP-Seq_MCF-7_Human0.79722128
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79615480
76EGR1_19032775_ChIP-ChIP_M12_Human0.79474184
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79272923
78GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78790048
79P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78775858
80CBP_21632823_ChIP-Seq_H3396_Human0.78512377
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77526040
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77524763
83RACK7_27058665_Chip-Seq_MCF-7_Human0.77206889
84BCAT_22108803_ChIP-Seq_LS180_Human0.77140052
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76176824
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75869727
87KLF5_25053715_ChIP-Seq_YYC3_Human0.75661094
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75195591
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.74919778
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.74911222
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74527326
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74269010
93CTCF_27219007_Chip-Seq_Bcells_Human0.74049803
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72535156
95TP63_23658742_ChIP-Seq_EP156T_Human0.72145831
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71005654
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.70356837
98SOX2_22085726_ChIP-Seq_NPCs_Mouse0.69490091
99AR_20517297_ChIP-Seq_VCAP_Human0.69251872
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69065507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.33814216
2MP0002139_abnormal_hepatobiliary_system6.25578578
3MP0005085_abnormal_gallbladder_physiolo5.81940423
4MP0001666_abnormal_nutrient_absorption4.88645125
5MP0005365_abnormal_bile_salt4.87118622
6MP0003183_abnormal_peptide_metabolism3.53863122
7MP0004019_abnormal_vitamin_homeostasis3.44628867
8MP0009840_abnormal_foam_cell3.37830166
9MP0004147_increased_porphyrin_level2.73329816
10MP0003252_abnormal_bile_duct2.69727009
11MP0003868_abnormal_feces_composition2.60099182
12MP0010329_abnormal_lipoprotein_level2.57900053
13MP0009379_abnormal_foot_pigmentation2.50947865
14MP0004264_abnormal_extraembryonic_tissu2.44533457
15MP0008875_abnormal_xenobiotic_pharmacok2.38961128
16MP0005332_abnormal_amino_acid2.35531082
17MP0003806_abnormal_nucleotide_metabolis2.09558091
18MP0010155_abnormal_intestine_physiology2.07152639
19MP0009643_abnormal_urine_homeostasis1.86361397
20MP0010234_abnormal_vibrissa_follicle1.84943755
21MP0002138_abnormal_hepatobiliary_system1.82845114
22MP0001764_abnormal_homeostasis1.80161926
23MP0005409_darkened_coat_color1.66374281
24MP0003195_calcinosis1.65114195
25MP0002876_abnormal_thyroid_physiology1.58841269
26MP0002118_abnormal_lipid_homeostasis1.48670760
27MP0005670_abnormal_white_adipose1.43909593
28MP0003866_abnormal_defecation1.38717260
29MP0000609_abnormal_liver_physiology1.38409292
30MP0001664_abnormal_digestion1.37820968
31MP0005636_abnormal_mineral_homeostasis1.34672429
32MP0009697_abnormal_copulation1.27853813
33MP0005166_decreased_susceptibility_to1.23223940
34MP0000538_abnormal_urinary_bladder1.18113055
35MP0003191_abnormal_cellular_cholesterol1.16346160
36MP0003718_maternal_effect1.15336525
37MP0000490_abnormal_crypts_of1.12863012
38MP0005584_abnormal_enzyme/coenzyme_acti1.12145645
39MP0004043_abnormal_pH_regulation1.12037370
40MP0003879_abnormal_hair_cell1.11910993
41MP0001765_abnormal_ion_homeostasis1.11757910
42MP0002136_abnormal_kidney_physiology1.11415517
43MP0010352_gastrointestinal_tract_polyps1.06822323
44MP0005535_abnormal_body_temperature1.03009758
45MP0000477_abnormal_intestine_morphology1.00534908
46MP0005319_abnormal_enzyme/_coenzyme0.99739774
47MP0000678_abnormal_parathyroid_gland0.98775973
48MP0004782_abnormal_surfactant_physiolog0.96101824
49MP0002971_abnormal_brown_adipose0.93633873
50MP0005451_abnormal_body_composition0.93384489
51MP0005448_abnormal_energy_balance0.91640692
52MP0001756_abnormal_urination0.90744001
53MP0002822_catalepsy0.85030310
54MP0008469_abnormal_protein_level0.82597921
55MP0009642_abnormal_blood_homeostasis0.82012475
56MP0001501_abnormal_sleep_pattern0.80387974
57MP0001663_abnormal_digestive_system0.80350335
58MP0001188_hyperpigmentation0.78629370
59MP0004858_abnormal_nervous_system0.76797572
60MP0000462_abnormal_digestive_system0.75293354
61MP0001873_stomach_inflammation0.73597482
62MP0001845_abnormal_inflammatory_respons0.73426406
63MP0000604_amyloidosis0.68471526
64MP0009764_decreased_sensitivity_to0.67103679
65MP0009785_altered_susceptibility_to0.66498356
66MP0009115_abnormal_fat_cell0.66170708
67MP0004270_analgesia0.66066641
68MP0005381_digestive/alimentary_phenotyp0.65751174
69MP0008872_abnormal_physiological_respon0.65493495
70MP0000230_abnormal_systemic_arterial0.59499176
71MP0005376_homeostasis/metabolism_phenot0.58388571
72MP0003300_gastrointestinal_ulcer0.57544415
73MP0000598_abnormal_liver_morphology0.57121219
74MP0002078_abnormal_glucose_homeostasis0.56197651
75MP0000249_abnormal_blood_vessel0.54714064
76MP0005334_abnormal_fat_pad0.54260559
77MP0005395_other_phenotype0.53828688
78MP0003638_abnormal_response/metabolism_0.52392809
79MP0005666_abnormal_adipose_tissue0.51060528
80MP0002796_impaired_skin_barrier0.47709293
81MP0003953_abnormal_hormone_level0.47199093
82MP0002098_abnormal_vibrissa_morphology0.47124822
83MP0009763_increased_sensitivity_to0.44965119
84MP0001881_abnormal_mammary_gland0.44129999
85MP0005058_abnormal_lysosome_morphology0.43561637
86MP0003329_amyloid_beta_deposits0.43347166
87MP0002396_abnormal_hematopoietic_system0.42615595
88MP0005025_abnormal_response_to0.41757879
89MP0002166_altered_tumor_susceptibility0.40707412
90MP0005408_hypopigmentation0.38622260
91MP0006082_CNS_inflammation0.38103319
92MP0003436_decreased_susceptibility_to0.36266409
93MP0005501_abnormal_skin_physiology0.35685079
94MP0006138_congestive_heart_failure0.35483906
95MP0001485_abnormal_pinna_reflex0.35198972
96MP0009333_abnormal_splenocyte_physiolog0.35043560
97MP0000465_gastrointestinal_hemorrhage0.34223939
98MP0002896_abnormal_bone_mineralization0.33326598
99MP0009765_abnormal_xenobiotic_induced0.30865892
100MP0003724_increased_susceptibility_to0.30673402

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)9.73968852
2Hypobetalipoproteinemia (HP:0003563)7.66674960
3Abnormality of proline metabolism (HP:0010907)6.29453164
4Hydroxyprolinuria (HP:0003080)6.29453164
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.02469582
6Malnutrition (HP:0004395)5.89266263
7Fat malabsorption (HP:0002630)5.10716065
8Systemic lupus erythematosus (HP:0002725)4.98078329
9Complement deficiency (HP:0004431)4.40599465
10Acanthocytosis (HP:0001927)4.40585180
11Abnormality of the vitamin B12 metabolism (HP:0004341)4.31498310
12Hyperglycinuria (HP:0003108)4.17400254
13Chronic diarrhea (HP:0002028)4.14200848
14Xanthomatosis (HP:0000991)4.11612754
15Abnormality of vitamin B metabolism (HP:0004340)4.05134675
16Hypolipoproteinemia (HP:0010981)3.97561446
17Abnormality of vitamin metabolism (HP:0100508)3.95886758
18Widely patent fontanelles and sutures (HP:0004492)3.94244485
19Abnormality of complement system (HP:0005339)3.85764113
20Ileus (HP:0002595)3.85682115
21Abnormality of urine glucose concentration (HP:0011016)3.85568280
22Glycosuria (HP:0003076)3.85568280
23Abnormality of serine family amino acid metabolism (HP:0010894)3.77400506
24Abnormality of glycine metabolism (HP:0010895)3.77400506
25Conjugated hyperbilirubinemia (HP:0002908)3.72484251
26Confusion (HP:0001289)3.68190599
27Steatorrhea (HP:0002570)3.47640323
28Proximal tubulopathy (HP:0000114)3.46497614
29Deep venous thrombosis (HP:0002625)3.38789382
30Pigmentary retinal degeneration (HP:0001146)3.38786919
31Alkalosis (HP:0001948)3.35865926
32Hyperammonemia (HP:0001987)3.35162540
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.23890073
34Nausea (HP:0002018)3.21180274
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.19526697
36Nephrolithiasis (HP:0000787)3.12374281
37Abnormality of pyrimidine metabolism (HP:0004353)3.11970168
38Intrahepatic cholestasis (HP:0001406)3.09467793
39Glomerulonephritis (HP:0000099)3.09410495
40Metabolic alkalosis (HP:0200114)3.04414360
41Hyperactive renin-angiotensin system (HP:0000841)3.01857915
42Hyperphosphaturia (HP:0003109)2.99638284
43Abnormality of nucleobase metabolism (HP:0010932)2.97735260
44Prolonged partial thromboplastin time (HP:0003645)2.94512753
45Abnormal urine phosphate concentration (HP:0012599)2.93562088
46Abnormality of purine metabolism (HP:0004352)2.91210927
47Hypophosphatemia (HP:0002148)2.90879607
48Facial shape deformation (HP:0011334)2.90525505
49Potter facies (HP:0002009)2.90525505
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90477090
51Thin bony cortex (HP:0002753)2.85682845
52Wide cranial sutures (HP:0010537)2.83772663
53Hyperuricemia (HP:0002149)2.83231945
54Increased purine levels (HP:0004368)2.83231945
55Abdominal distention (HP:0003270)2.73345555
56Megaloblastic anemia (HP:0001889)2.69165155
57Epidermoid cyst (HP:0200040)2.68992763
58Hyperlipoproteinemia (HP:0010980)2.64063382
59Generalized aminoaciduria (HP:0002909)2.64042002
60Hemorrhage of the eye (HP:0011885)2.62583633
61Metabolic acidosis (HP:0001942)2.59597371
62Nephritis (HP:0000123)2.57133601
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.54548775
64Gout (HP:0001997)2.50758374
65Rickets (HP:0002748)2.41736834
66Poikilocytosis (HP:0004447)2.41332280
67Focal segmental glomerulosclerosis (HP:0000097)2.35403177
68Decreased circulating renin level (HP:0003351)2.34478436
69Irritability (HP:0000737)2.28769784
70Congenital sensorineural hearing impairment (HP:0008527)2.26349449
71Abnormality of renin-angiotensin system (HP:0000847)2.22563034
72Hypotension (HP:0002615)2.20839315
73Enlarged epiphyses (HP:0010580)2.14935876
74Delayed epiphyseal ossification (HP:0002663)2.14634625
75Cerebral palsy (HP:0100021)2.12570419
76Osteomalacia (HP:0002749)2.11890070
77Abnormal enzyme/coenzyme activity (HP:0012379)2.07815605
78Abnormality of alkaline phosphatase activity (HP:0004379)2.04801414
79Pancreatitis (HP:0001733)2.04392463
80Posterior subcapsular cataract (HP:0007787)2.02349598
81Dicarboxylic aciduria (HP:0003215)1.98581752
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98581752
83Vascular calcification (HP:0004934)1.97158492
84Delayed CNS myelination (HP:0002188)1.94795351
85Protuberant abdomen (HP:0001538)1.94307888
86Elevated alkaline phosphatase (HP:0003155)1.93926143
87Abnormality of magnesium homeostasis (HP:0004921)1.92687560
88Eczematoid dermatitis (HP:0000976)1.92185591
89Joint hemorrhage (HP:0005261)1.91273063
90Abnormality of small intestinal villus morphology (HP:0011472)1.90441545
91Villous atrophy (HP:0011473)1.90441545
92Renal tubular acidosis (HP:0001947)1.87742278
93Lethargy (HP:0001254)1.87370390
94Hyperparathyroidism (HP:0000843)1.86446326
95Hypophosphatemic rickets (HP:0004912)1.86196614
96Hyperbilirubinemia (HP:0002904)1.85095119
97Renal tubular dysfunction (HP:0000124)1.82268152
98Abnormal glucose tolerance (HP:0001952)1.82262849
99Abnormality of serum amino acid levels (HP:0003112)1.82039813
100Glomerulosclerosis (HP:0000096)1.81960935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.38655951
2ERN14.64760891
3MST1R4.13885459
4RIPK13.62919122
5PRKG23.28954479
6MAP3K102.87362250
7OXSR12.61235574
8STK392.41267131
9EPHA22.22220317
10FGFR42.17568445
11MAP3K21.91783240
12TYK21.83572673
13PDK21.74763694
14EPHA31.69573751
15MAP3K121.68937097
16TESK21.65532589
17MET1.58263835
18PTK61.54096715
19PRPF4B1.37441589
20TNIK1.27960004
21PIK3CA1.26285990
22FGFR31.25553024
23GRK61.21264158
24EPHB11.20809796
25AKT31.20536711
26EPHB21.16346983
27EPHA41.15973697
28DDR21.14070354
29MAP3K11.12944066
30STK241.11048448
31MYLK1.10179958
32MST41.09579775
33NLK1.02826518
34PRKACG1.02673883
35MAP4K10.98426376
36MATK0.97432760
37PRKAA20.96617839
38PDPK10.96303597
39MAP2K20.96182468
40MAPK110.94847050
41ERBB20.88344626
42MAP3K30.84206060
43LMTK20.82303293
44PIK3CG0.81542405
45PIM10.76739328
46MAP2K60.75602186
47CASK0.70912194
48PRKCZ0.70319580
49RIPK40.70258972
50PDK10.70107175
51FER0.69654390
52DYRK1B0.68946045
53PRKCA0.65091441
54MAP3K110.64212722
55CDC42BPA0.64131438
56ABL20.61546315
57JAK10.60478406
58KSR20.60152670
59TESK10.59941244
60BMPR20.59287439
61TBK10.58793295
62WNK30.56144415
63IRAK10.54809521
64RET0.54184215
65JAK20.51598097
66TAOK10.48330128
67SRC0.47533235
68CDK60.46581564
69CSF1R0.46563716
70PTK20.40880807
71PRKCD0.40864897
72YES10.39422940
73IGF1R0.37598429
74FYN0.37591869
75CAMK2G0.35481334
76CAMK2D0.34161742
77PDGFRA0.33477678
78PRKACA0.31804452
79IKBKE0.31422885
80TRIB30.30004515
81NEK60.27407714
82ITK0.27230477
83ZAP700.25667717
84GRK10.24865994
85PAK40.24844449
86FRK0.24228981
87DAPK20.23414759
88MAP3K140.22592562
89CAMK2B0.22492049
90BMX0.22426991
91SYK0.22348369
92TEC0.22241531
93BTK0.21549687
94MELK0.20891518
95CSK0.20204763
96PRKG10.19947405
97PRKCB0.19570024
98NEK90.18824117
99CDK190.18304907
100JAK30.17737801

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.96571281
2Fat digestion and absorption_Homo sapiens_hsa049753.52171075
3Vitamin digestion and absorption_Homo sapiens_hsa049773.51199974
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41997808
5Renin-angiotensin system_Homo sapiens_hsa046143.02839152
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.95925784
7Retinol metabolism_Homo sapiens_hsa008302.92897326
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.92770180
9Chemical carcinogenesis_Homo sapiens_hsa052042.74610827
10Arginine biosynthesis_Homo sapiens_hsa002202.74118358
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.65616969
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.59541635
13Histidine metabolism_Homo sapiens_hsa003402.50429970
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.28165531
15* Starch and sucrose metabolism_Homo sapiens_hsa005002.23005735
16Linoleic acid metabolism_Homo sapiens_hsa005912.17093800
17Bile secretion_Homo sapiens_hsa049762.02983560
18Fatty acid degradation_Homo sapiens_hsa000712.00506140
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.95212014
20PPAR signaling pathway_Homo sapiens_hsa033201.87544329
21* Cyanoamino acid metabolism_Homo sapiens_hsa004601.85957239
22Mineral absorption_Homo sapiens_hsa049781.84811746
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.82549855
24Protein digestion and absorption_Homo sapiens_hsa049741.81316712
25Phenylalanine metabolism_Homo sapiens_hsa003601.80917354
26Tryptophan metabolism_Homo sapiens_hsa003801.72326845
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65583288
28Fructose and mannose metabolism_Homo sapiens_hsa000511.55917671
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.51071536
30Galactose metabolism_Homo sapiens_hsa000521.49222345
31Arachidonic acid metabolism_Homo sapiens_hsa005901.45445813
32Complement and coagulation cascades_Homo sapiens_hsa046101.41049930
33Arginine and proline metabolism_Homo sapiens_hsa003301.39938474
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.37247506
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32917638
36Tyrosine metabolism_Homo sapiens_hsa003501.31397090
37Sulfur metabolism_Homo sapiens_hsa009201.30438953
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29477584
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15712363
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12943602
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12886280
42Butanoate metabolism_Homo sapiens_hsa006501.02489064
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01994138
44Glycerolipid metabolism_Homo sapiens_hsa005611.01053054
45Peroxisome_Homo sapiens_hsa041460.96381711
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92495605
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86393804
48Staphylococcus aureus infection_Homo sapiens_hsa051500.84875140
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80029146
50Fatty acid metabolism_Homo sapiens_hsa012120.77205848
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76015820
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71263595
53Biosynthesis of amino acids_Homo sapiens_hsa012300.63076658
54Ether lipid metabolism_Homo sapiens_hsa005650.59776172
55beta-Alanine metabolism_Homo sapiens_hsa004100.58812130
56Pyruvate metabolism_Homo sapiens_hsa006200.57710587
57Carbon metabolism_Homo sapiens_hsa012000.55458670
58Glutathione metabolism_Homo sapiens_hsa004800.53686620
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53085981
60ABC transporters_Homo sapiens_hsa020100.53018239
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52311718
62Propanoate metabolism_Homo sapiens_hsa006400.48133413
63Asthma_Homo sapiens_hsa053100.47648738
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46525321
65Sphingolipid metabolism_Homo sapiens_hsa006000.44866991
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.43572052
67Pentose phosphate pathway_Homo sapiens_hsa000300.41084793
68Folate biosynthesis_Homo sapiens_hsa007900.39780153
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.37473687
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35801341
71Vitamin B6 metabolism_Homo sapiens_hsa007500.35667919
72Fatty acid biosynthesis_Homo sapiens_hsa000610.33236179
73* Metabolic pathways_Homo sapiens_hsa011000.33163714
74Sulfur relay system_Homo sapiens_hsa041220.31860034
75Pancreatic secretion_Homo sapiens_hsa049720.31518789
76Insulin resistance_Homo sapiens_hsa049310.30924907
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29028469
78Allograft rejection_Homo sapiens_hsa053300.27777474
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.24099904
80Autoimmune thyroid disease_Homo sapiens_hsa053200.23955141
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22958500
82Graft-versus-host disease_Homo sapiens_hsa053320.20640982
83Prion diseases_Homo sapiens_hsa050200.17471726
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.17252131
85Other glycan degradation_Homo sapiens_hsa005110.16861661
86Glucagon signaling pathway_Homo sapiens_hsa049220.16370594
87Fatty acid elongation_Homo sapiens_hsa000620.15307364
88Pertussis_Homo sapiens_hsa051330.13875685
89Type I diabetes mellitus_Homo sapiens_hsa049400.09747359
90Renin secretion_Homo sapiens_hsa049240.06515228
91Serotonergic synapse_Homo sapiens_hsa047260.06327333
92Thyroid hormone synthesis_Homo sapiens_hsa049180.06195150
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06040803
94Cocaine addiction_Homo sapiens_hsa050300.01374395
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.00917053
96Antigen processing and presentation_Homo sapiens_hsa04612-0.0406124
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0357245
98African trypanosomiasis_Homo sapiens_hsa05143-0.0334920
99Hepatitis C_Homo sapiens_hsa05160-0.0308016
100AMPK signaling pathway_Homo sapiens_hsa04152-0.0065115

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