ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	coenzyme catabolic process (GO:0009109)	5.82670017
2	DNA strand renaturation (GO:0000733)	4.96003967
3	rRNA methylation (GO:0031167)	4.52614767
4	one-carbon compound transport (GO:0019755)	4.47392278
5	DNA replication checkpoint (GO:0000076)	4.35290693
6	meiotic chromosome segregation (GO:0045132)	4.33530753
7	negative regulation of cell aging (GO:0090344)	4.24343942
8	rRNA modification (GO:0000154)	4.21274826
9	polyol transport (GO:0015791)	4.09095348
10	spermatid nucleus differentiation (GO:0007289)	4.06142565
11	regulation of mitotic spindle organization (GO:0060236)	3.97432376
12	negative regulation of dendrite morphogenesis (GO:0050774)	3.94494397
13	DNA topological change (GO:0006265)	3.83431665
14	UTP biosynthetic process (GO:0006228)	3.75303822
15	GDP-mannose metabolic process (GO:0019673)	3.73550848
16	guanosine-containing compound biosynthetic process (GO:1901070)	3.62332072
17	purine nucleotide salvage (GO:0032261)	3.60079930
18	GMP metabolic process (GO:0046037)	3.58439153
19	C-terminal protein lipidation (GO:0006501)	3.56797913
20	kinetochore organization (GO:0051383)	3.48315939
21	kinetochore assembly (GO:0051382)	3.46002359
22	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.45693238
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.36106416
24	purine-containing compound salvage (GO:0043101)	3.34831301
25	GTP biosynthetic process (GO:0006183)	3.30507314
26	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.24223054
27	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.24223054
28	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.24223054
29	pseudouridine synthesis (GO:0001522)	3.15712240
30	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.15637828
31	negative regulation of histone acetylation (GO:0035067)	3.15332192
32	DNA double-strand break processing (GO:0000729)	3.14994124
33	nucleoside salvage (GO:0043174)	3.06883746
34	cofactor catabolic process (GO:0051187)	3.06650647
35	regulation of mitochondrial translation (GO:0070129)	3.06392893
36	UTP metabolic process (GO:0046051)	3.00664727
37	nucleotide salvage (GO:0043173)	3.00135377
38	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.00091894
39	ribosome biogenesis (GO:0042254)	2.99167741
40	cornea development in camera-type eye (GO:0061303)	2.98385725
41	negative regulation of JAK-STAT cascade (GO:0046426)	2.97289506
42	mitotic sister chromatid segregation (GO:0000070)	2.97040581
43	positive regulation of gluconeogenesis (GO:0045722)	2.95996376
44	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.95217702
45	telomere maintenance via semi-conservative replication (GO:0032201)	2.95167023
46	mismatch repair (GO:0006298)	2.94957954
47	DNA catabolic process, exonucleolytic (GO:0000738)	2.93036699
48	cellular response to ATP (GO:0071318)	2.92395841
49	nephron tubule development (GO:0072080)	2.89326218
50	GPI anchor biosynthetic process (GO:0006506)	2.87856493
51	auditory receptor cell stereocilium organization (GO:0060088)	2.85733839
52	C-terminal protein amino acid modification (GO:0018410)	2.85575467
53	cytochrome complex assembly (GO:0017004)	2.85308383
54	histone H3-K9 methylation (GO:0051567)	2.84588622
55	DNA replication initiation (GO:0006270)	2.83781543
56	mannosylation (GO:0097502)	2.80902501
57	CTP biosynthetic process (GO:0006241)	2.80507000
58	CTP metabolic process (GO:0046036)	2.80507000
59	intracellular pH reduction (GO:0051452)	2.80279371
60	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.78134671
61	adenosine receptor signaling pathway (GO:0001973)	2.77285215
62	rRNA transcription (GO:0009303)	2.76810277
63	presynaptic membrane assembly (GO:0097105)	2.76253758
64	mRNA cleavage (GO:0006379)	2.73532959
65	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.73384031
66	telomere maintenance via telomere lengthening (GO:0010833)	2.70321518
67	facial nerve structural organization (GO:0021612)	2.69376226
68	urinary tract smooth muscle contraction (GO:0014848)	2.68731442
69	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.68447220
70	DNA excision (GO:0044349)	2.68447220
71	mitotic chromosome condensation (GO:0007076)	2.68140540
72	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.68113198
73	positive regulation of chromosome segregation (GO:0051984)	2.66802082
74	nucleobase biosynthetic process (GO:0046112)	2.65216787
75	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	2.65033197
76	regulation of spindle organization (GO:0090224)	2.64502389
77	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.63780916
78	apical protein localization (GO:0045176)	2.63057766
79	renal tubule development (GO:0061326)	2.62720411
80	DNA strand elongation involved in DNA replication (GO:0006271)	2.62143146
81	glutathione derivative biosynthetic process (GO:1901687)	2.61173736
82	glutathione derivative metabolic process (GO:1901685)	2.61173736
83	melanin biosynthetic process (GO:0042438)	2.59919885
84	synapsis (GO:0007129)	2.58720609
85	pH reduction (GO:0045851)	2.57093099
86	nucleoside transmembrane transport (GO:1901642)	2.56354435
87	DNA strand elongation (GO:0022616)	2.55395694
88	GPI anchor metabolic process (GO:0006505)	2.53780013
89	sister chromatid segregation (GO:0000819)	2.49964912
90	inositol phosphate catabolic process (GO:0071545)	2.49876159
91	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.49733833
92	DNA replication (GO:0006260)	2.49021911
93	histone H2A monoubiquitination (GO:0035518)	2.48459513
94	positive regulation of protein kinase C signaling (GO:0090037)	2.47193076
95	mitotic recombination (GO:0006312)	2.45768059
96	centrosome duplication (GO:0051298)	2.45258604
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.44512070
98	base-excision repair (GO:0006284)	2.44165077
99	positive regulation of lamellipodium assembly (GO:0010592)	2.44158430
100	forebrain neuron development (GO:0021884)	2.43716629

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.76248130
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.31085428
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.29926336
4	VDR_21846776_ChIP-Seq_THP-1_Human	2.87099033
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.85644886
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81175208
7	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.60656139
8	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.56354887
9	* XRN2_22483619_ChIP-Seq_HELA_Human	2.54513766
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.53772463
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.49893900
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.49054815
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.35694506
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.26166362
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.25552949
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21348433
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20681318
18	P68_20966046_ChIP-Seq_HELA_Human	2.15300997
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.06079104
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.02214526
21	CIITA_25753668_ChIP-Seq_RAJI_Human	1.98643019
22	KDM5A_27292631_Chip-Seq_BREAST_Human	1.96734163
23	GABP_19822575_ChIP-Seq_HepG2_Human	1.95070754
24	LXR_22292898_ChIP-Seq_THP-1_Human	1.90269570
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.87565676
26	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.85545379
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.85357491
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.78875313
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.75052735
30	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.70763972
31	MAF_26560356_Chip-Seq_TH2_Human	1.69128849
32	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67927509
33	* TTF2_22483619_ChIP-Seq_HELA_Human	1.66856552
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65633098
35	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.64680897
36	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.64152669
37	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.63360265
38	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.62518883
39	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.61882786
40	E2F1_20622854_ChIP-Seq_HELA_Human	1.59991680
41	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.58033031
42	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.55716012
43	BCL6_27268052_Chip-Seq_Bcells_Human	1.55362696
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.55164239
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.54621595
46	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.51389573
47	BCOR_27268052_Chip-Seq_Bcells_Human	1.50258395
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49704162
49	SMC4_20622854_ChIP-Seq_HELA_Human	1.45416533
50	PHF8_20622854_ChIP-Seq_HELA_Human	1.44697483
51	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.41881376
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39650207
53	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.38694711
54	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.38543621
55	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.37921505
56	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.36899357
57	* CTCF_27219007_Chip-Seq_Bcells_Human	1.36698407
58	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.36507852
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.35239956
60	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.34340682
61	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.34194617
62	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.30536193
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.27876947
64	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26927280
65	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24875929
66	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.24348576
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.22982401
68	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.22539266
69	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.21956956
70	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.21751637
71	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.21142913
72	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.20839229
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20596660
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.20387487
75	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.19619753
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.17044141
77	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.15628070
78	* CTCF_21964334_Chip-Seq_Bcells_Human	1.15199980
79	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.14712603
80	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.12888396
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.12799764
82	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.11010087
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.09392614
84	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.07661294
85	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05781987
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04852274
87	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.03467757
88	* SA1_27219007_Chip-Seq_Bcells_Human	1.03235708
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.02149884
90	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.02093125
91	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.01528571
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.00095045
93	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.99661313
94	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.98913770
95	MAF_26560356_Chip-Seq_TH1_Human	0.98686590
96	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.98300579
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98266265
98	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.98236725
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98052566
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.96619566

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	5.03798874
2	MP0003136_yellow_coat_color	4.28795545
3	MP0005174_abnormal_tail_pigmentation	3.53167392
4	MP0003111_abnormal_nucleus_morphology	3.17883315
5	MP0000566_synostosis	3.10497860
6	MP0005423_abnormal_somatic_nervous	3.00794681
7	MP0010094_abnormal_chromosome_stability	2.97540918
8	MP0005083_abnormal_biliary_tract	2.70850455
9	MP0002877_abnormal_melanocyte_morpholog	2.69729779
10	MP0008007_abnormal_cellular_replicative	2.45838974
11	MP0001986_abnormal_taste_sensitivity	2.37754877
12	MP0004147_increased_porphyrin_level	2.34506387
13	MP0002009_preneoplasia	2.23504387
14	MP0002938_white_spotting	2.18380576
15	MP0004859_abnormal_synaptic_plasticity	2.14774744
16	MP0008058_abnormal_DNA_repair	2.04977415
17	MP0000015_abnormal_ear_pigmentation	2.04571178
18	MP0001968_abnormal_touch/_nociception	1.84613088
19	MP0001502_abnormal_circadian_rhythm	1.81531079
20	MP0005253_abnormal_eye_physiology	1.77707416
21	MP0001188_hyperpigmentation	1.76555186
22	MP0000013_abnormal_adipose_tissue	1.75238329
23	MP0005410_abnormal_fertilization	1.69565637
24	MP0009278_abnormal_bone_marrow	1.68124402
25	MP0003077_abnormal_cell_cycle	1.60298175
26	MP0001661_extended_life_span	1.57574422
27	MP0003172_abnormal_lysosome_physiology	1.56876069
28	MP0002396_abnormal_hematopoietic_system	1.56178248
29	MP0005551_abnormal_eye_electrophysiolog	1.50523423
30	MP0002160_abnormal_reproductive_system	1.49650570
31	MP0005220_abnormal_exocrine_pancreas	1.48405235
32	MP0002736_abnormal_nociception_after	1.47622578
33	MP0002638_abnormal_pupillary_reflex	1.45765102
34	MP0002095_abnormal_skin_pigmentation	1.43750350
35	MP0005076_abnormal_cell_differentiation	1.43230753
36	MP0006072_abnormal_retinal_apoptosis	1.40847526
37	MP0005332_abnormal_amino_acid	1.34429738
38	MP0009046_muscle_twitch	1.30569395
39	MP0004808_abnormal_hematopoietic_stem	1.28418825
40	MP0003693_abnormal_embryo_hatching	1.28124392
41	MP0003786_premature_aging	1.27090481
42	MP0006292_abnormal_olfactory_placode	1.26944499
43	MP0002735_abnormal_chemical_nociception	1.24691933
44	MP0005075_abnormal_melanosome_morpholog	1.20813229
45	MP0000372_irregular_coat_pigmentation	1.19640801
46	MP0009840_abnormal_foam_cell	1.19500574
47	MP0005257_abnormal_intraocular_pressure	1.13880080
48	MP0001348_abnormal_lacrimal_gland	1.12963168
49	MP0003283_abnormal_digestive_organ	1.12491683
50	MP0001756_abnormal_urination	1.12438091
51	MP0000681_abnormal_thyroid_gland	1.11663735
52	MP0000538_abnormal_urinary_bladder	1.09905822
53	MP0001270_distended_abdomen	1.08785925
54	MP0001664_abnormal_digestion	1.08532928
55	MP0002177_abnormal_outer_ear	1.07719862
56	MP0003635_abnormal_synaptic_transmissio	1.06705311
57	MP0004885_abnormal_endolymph	1.05215583
58	MP0003880_abnormal_central_pattern	1.05201538
59	MP0001905_abnormal_dopamine_level	1.05150377
60	MP0001545_abnormal_hematopoietic_system	1.04968239
61	MP0005397_hematopoietic_system_phenotyp	1.04968239
62	MP0004381_abnormal_hair_follicle	1.04145319
63	MP0000678_abnormal_parathyroid_gland	0.94833482
64	MP0010030_abnormal_orbit_morphology	0.92814680
65	MP0002064_seizures	0.92682767
66	MP0001764_abnormal_homeostasis	0.90956580
67	MP0000003_abnormal_adipose_tissue	0.89520690
68	MP0002234_abnormal_pharynx_morphology	0.89394490
69	MP0004043_abnormal_pH_regulation	0.87577490
70	MP0001346_abnormal_lacrimal_gland	0.87005628
71	MP0005646_abnormal_pituitary_gland	0.85035168
72	MP0008057_abnormal_DNA_replication	0.84489627
73	MP0005501_abnormal_skin_physiology	0.82281688
74	MP0002272_abnormal_nervous_system	0.82012296
75	MP0001963_abnormal_hearing_physiology	0.80324492
76	MP0002063_abnormal_learning/memory/cond	0.80009810
77	MP0002249_abnormal_larynx_morphology	0.79485263
78	MP0000358_abnormal_cell_content/	0.77301252
79	MP0008569_lethality_at_weaning	0.76585761
80	MP0001529_abnormal_vocalization	0.76479594
81	MP0005367_renal/urinary_system_phenotyp	0.75999877
82	MP0000516_abnormal_urinary_system	0.75999877
83	MP0009745_abnormal_behavioral_response	0.72197556
84	MP0003698_abnormal_male_reproductive	0.71618150
85	MP0003943_abnormal_hepatobiliary_system	0.71574022
86	MP0005391_vision/eye_phenotype	0.71069394
87	MP0002572_abnormal_emotion/affect_behav	0.71024562
88	MP0008932_abnormal_embryonic_tissue	0.70479107
89	MP0000026_abnormal_inner_ear	0.68281863
90	MP0005389_reproductive_system_phenotype	0.67077176
91	MP0008260_abnormal_autophagy	0.66634567
92	MP0005623_abnormal_meninges_morphology	0.66004572
93	MP0000579_abnormal_nail_morphology	0.65958241
94	MP0001929_abnormal_gametogenesis	0.65231208
95	MP0001970_abnormal_pain_threshold	0.63973199
96	MP0010771_integument_phenotype	0.63867951
97	MP0004957_abnormal_blastocyst_morpholog	0.63755201
98	MP0002075_abnormal_coat/hair_pigmentati	0.63346645
99	MP0002909_abnormal_adrenal_gland	0.59010446
100	MP0006035_abnormal_mitochondrial_morpho	0.57782159

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Squamous cell carcinoma (HP:0002860)	4.80505304
2	Attenuation of retinal blood vessels (HP:0007843)	4.53923132
3	Absent/shortened dynein arms (HP:0200106)	4.10726410
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.10726410
5	Testicular atrophy (HP:0000029)	3.86487553
6	Cutaneous melanoma (HP:0012056)	3.58533408
7	Poikiloderma (HP:0001029)	3.54398051
8	Abnormality of the pons (HP:0007361)	3.47782951
9	Bony spicule pigmentary retinopathy (HP:0007737)	3.29557066
10	Cerebellar dysplasia (HP:0007033)	3.25028429
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.22930076
12	Rib fusion (HP:0000902)	3.22596911
13	Decreased central vision (HP:0007663)	3.21224476
14	Hypoplasia of the pons (HP:0012110)	3.19625326
15	White forelock (HP:0002211)	3.19351613
16	Abnormal ciliary motility (HP:0012262)	3.17492575
17	Abnormal respiratory epithelium morphology (HP:0012253)	3.09697330
18	Abnormal respiratory motile cilium morphology (HP:0005938)	3.09697330
19	Renal Fanconi syndrome (HP:0001994)	3.03928078
20	Hyperinsulinemic hypoglycemia (HP:0000825)	2.98228214
21	Microvesicular hepatic steatosis (HP:0001414)	2.93897926
22	Birth length less than 3rd percentile (HP:0003561)	2.93876827
23	Absent thumb (HP:0009777)	2.88823128
24	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.86485530
25	Akinesia (HP:0002304)	2.85476607
26	Patchy hypopigmentation of hair (HP:0011365)	2.82395919
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.78208471
28	Premature graying of hair (HP:0002216)	2.77907871
29	Chromsome breakage (HP:0040012)	2.77018078
30	Rectal fistula (HP:0100590)	2.76549700
31	Rectovaginal fistula (HP:0000143)	2.76549700
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.76475411
33	Respiratory difficulties (HP:0002880)	2.67625014
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.55469692
35	Intestinal fistula (HP:0100819)	2.54155638
36	Increased hepatocellular lipid droplets (HP:0006565)	2.52251156
37	Congenital stationary night blindness (HP:0007642)	2.49219460
38	Chorioretinal atrophy (HP:0000533)	2.47867102
39	Turricephaly (HP:0000262)	2.46835780
40	Pendular nystagmus (HP:0012043)	2.44630138
41	Ulnar bowing (HP:0003031)	2.43147436
42	Bile duct proliferation (HP:0001408)	2.34737243
43	Abnormal biliary tract physiology (HP:0012439)	2.34737243
44	Vaginal fistula (HP:0004320)	2.34250901
45	Abnormal respiratory motile cilium physiology (HP:0012261)	2.32676238
46	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.31023041
47	Type II lissencephaly (HP:0007260)	2.23096693
48	Amblyopia (HP:0000646)	2.22736987
49	Abnormality of chromosome stability (HP:0003220)	2.16694827
50	Dyschromatopsia (HP:0007641)	2.14949197
51	Aplasia/Hypoplasia of the patella (HP:0006498)	2.14409236
52	Loss of speech (HP:0002371)	2.13550497
53	Lipid accumulation in hepatocytes (HP:0006561)	2.13324078
54	Mesangial abnormality (HP:0001966)	2.12162201
55	Duplicated collecting system (HP:0000081)	2.12107478
56	Male infertility (HP:0003251)	2.11723717
57	Polydipsia (HP:0001959)	2.10718550
58	Abnormal drinking behavior (HP:0030082)	2.10718550
59	Patellar aplasia (HP:0006443)	2.10669892
60	Abnormality of DNA repair (HP:0003254)	2.09911326
61	Abnormality of the renal collecting system (HP:0004742)	2.09163478
62	Prolonged neonatal jaundice (HP:0006579)	2.08551017
63	Annular pancreas (HP:0001734)	2.05453571
64	Hypoplastic pelvis (HP:0008839)	2.03175096
65	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.02343224
66	Hemiparesis (HP:0001269)	1.97803701
67	Aplasia of the musculature (HP:0100854)	1.97324664
68	Abnormality of the preputium (HP:0100587)	1.96014676
69	Retinal dysplasia (HP:0007973)	1.94823127
70	Facial hemangioma (HP:0000329)	1.93928545
71	Optic nerve coloboma (HP:0000588)	1.91940951
72	Breast hypoplasia (HP:0003187)	1.87937645
73	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.84104382
74	Progressive microcephaly (HP:0000253)	1.83025835
75	Meckel diverticulum (HP:0002245)	1.81403396
76	Severe muscular hypotonia (HP:0006829)	1.77256192
77	Brushfield spots (HP:0001088)	1.77207282
78	Epiphyseal stippling (HP:0010655)	1.76838410
79	Ectopic kidney (HP:0000086)	1.75883505
80	Hypoglycemic seizures (HP:0002173)	1.74509697
81	Abnormality of cochlea (HP:0000375)	1.73444068
82	Myelodysplasia (HP:0002863)	1.73178127
83	Neonatal respiratory distress (HP:0002643)	1.73146246
84	Abnormality of midbrain morphology (HP:0002418)	1.73091615
85	Molar tooth sign on MRI (HP:0002419)	1.73091615
86	Abnormality of liposaccharide metabolism (HP:0010968)	1.72565026
87	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.72565026
88	Abnormality of glycolipid metabolism (HP:0010969)	1.72565026
89	Abnormality of the fingertips (HP:0001211)	1.72474389
90	Delayed epiphyseal ossification (HP:0002663)	1.72276675
91	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.71354222
92	Dicarboxylic aciduria (HP:0003215)	1.71354222
93	Ketoacidosis (HP:0001993)	1.68465806
94	Abnormality of the ileum (HP:0001549)	1.68361784
95	Neoplasm of the adrenal cortex (HP:0100641)	1.64713719
96	Abnormal epiphyseal ossification (HP:0010656)	1.63920084
97	Slender long bone (HP:0003100)	1.62695456
98	Sloping forehead (HP:0000340)	1.62665638
99	Cortical visual impairment (HP:0100704)	1.59677978
100	Severe visual impairment (HP:0001141)	1.57966195

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.05736821
2	VRK2	3.39786807
3	STK16	3.12270500
4	MAP2K3	2.98118112
5	NEK2	2.88305281
6	DAPK2	2.72618121
7	TLK1	2.70469566
8	BUB1	2.47727399
9	WNK4	2.43894716
10	EIF2AK1	2.29367349
11	FGFR2	2.27536832
12	PDK2	2.24796788
13	MAPK15	2.11444955
14	PLK4	1.93902650
15	TAF1	1.78748836
16	BRSK1	1.74653346
17	PBK	1.71964116
18	VRK1	1.64654098
19	KIT	1.64603320
20	MAP4K2	1.60401992
21	CHEK2	1.52423305
22	TTK	1.50503718
23	EIF2AK3	1.50495322
24	SMG1	1.49426991
25	ZAK	1.46651882
26	CCNB1	1.43883765
27	BMPR1B	1.40814683
28	MST1R	1.39145696
29	EPHA4	1.30633902
30	DAPK1	1.29847628
31	STK39	1.29401024
32	MAP3K3	1.29396473
33	ATR	1.25794698
34	GRK5	1.18396218
35	FLT3	1.17812905
36	PLK3	1.16630925
37	MAP2K6	1.16590824
38	CDK19	1.15029978
39	MAP3K6	1.13682213
40	STK11	1.12071671
41	PAK6	1.10748320
42	PLK1	1.05281895
43	CDC7	1.02213498
44	MUSK	1.00932873
45	PRKD2	0.95565741
46	IRAK2	0.94689595
47	TNK2	0.94161881
48	MAP3K13	0.91811560
49	JAK3	0.88202127
50	STK38	0.88135866
51	PASK	0.85716144
52	MARK3	0.84561601
53	CDK11A	0.84051489
54	NUAK1	0.80905863
55	TBK1	0.78118451
56	NEK6	0.78000518
57	WEE1	0.77320011
58	OXSR1	0.75598012
59	CDK15	0.73551563
60	PLK2	0.72478700
61	MAPKAPK5	0.71695976
62	MELK	0.69944006
63	CSNK1G3	0.69936086
64	AURKA	0.67084546
65	RPS6KB2	0.66565507
66	CDK18	0.65298593
67	MAP3K7	0.65032581
68	CDK3	0.63848214
69	GRK6	0.59698590
70	NTRK2	0.59253193
71	CAMKK1	0.58482469
72	CDK14	0.58294496
73	CSNK1A1L	0.57888129
74	TESK2	0.54776014
75	PIM2	0.53075181
76	NTRK3	0.51467234
77	AURKB	0.50238423
78	MET	0.49555176
79	PRKG2	0.47341158
80	CHEK1	0.44853919
81	ADRBK1	0.44613421
82	SIK1	0.43337436
83	CSNK1D	0.42057881
84	CAMK1	0.41952640
85	CDK1	0.41028445
86	CDK2	0.40411537
87	NME2	0.39821108
88	ATM	0.38754439
89	SIK2	0.38612114
90	CSNK1G2	0.38258132
91	MAPK11	0.35822131
92	NME1	0.35620887
93	CSNK1G1	0.35416302
94	WNK1	0.33955683
95	DAPK3	0.33678630
96	EIF2AK2	0.32316934
97	INSRR	0.31954913
98	PRKCQ	0.30854373
99	PHKG1	0.30562082
100	PHKG2	0.30562082

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	4.07053920
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.72155696
3	Homologous recombination_Homo sapiens_hsa03440	3.50382040
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.47427712
5	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.30344178
6	Sulfur relay system_Homo sapiens_hsa04122	2.94601023
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.93058711
8	Base excision repair_Homo sapiens_hsa03410	2.88517748
9	DNA replication_Homo sapiens_hsa03030	2.71141814
10	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.35755018
11	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.86403715
12	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.74033841
13	Nucleotide excision repair_Homo sapiens_hsa03420	1.66680001
14	RNA polymerase_Homo sapiens_hsa03020	1.64539359
15	Fatty acid metabolism_Homo sapiens_hsa01212	1.54030469
16	Basal transcription factors_Homo sapiens_hsa03022	1.47562587
17	Lysine degradation_Homo sapiens_hsa00310	1.41130879
18	Mismatch repair_Homo sapiens_hsa03430	1.39504355
19	Lysosome_Homo sapiens_hsa04142	1.39441004
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39295088
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37147660
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.37104641
23	Glutathione metabolism_Homo sapiens_hsa00480	1.31949862
24	Ribosome_Homo sapiens_hsa03010	1.28694072
25	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.27396776
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.22847083
27	RNA transport_Homo sapiens_hsa03013	1.20106546
28	Folate biosynthesis_Homo sapiens_hsa00790	1.18823975
29	Cell cycle_Homo sapiens_hsa04110	1.15700391
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15127489
31	p53 signaling pathway_Homo sapiens_hsa04115	1.13284983
32	mTOR signaling pathway_Homo sapiens_hsa04150	1.02947912
33	Sphingolipid metabolism_Homo sapiens_hsa00600	1.00946580
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00702098
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.99698945
36	Insulin secretion_Homo sapiens_hsa04911	0.99070015
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.97674202
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96437355
39	Nicotine addiction_Homo sapiens_hsa05033	0.92843038
40	Regulation of autophagy_Homo sapiens_hsa04140	0.92269638
41	Purine metabolism_Homo sapiens_hsa00230	0.91627887
42	Oxidative phosphorylation_Homo sapiens_hsa00190	0.91176622
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88848232
44	Fatty acid elongation_Homo sapiens_hsa00062	0.88718714
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.87790429
46	One carbon pool by folate_Homo sapiens_hsa00670	0.86914083
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.85869382
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85593119
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84425888
50	Spliceosome_Homo sapiens_hsa03040	0.80661569
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.76101054
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71119880
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69371854
54	Oocyte meiosis_Homo sapiens_hsa04114	0.69078407
55	Melanogenesis_Homo sapiens_hsa04916	0.67349053
56	ABC transporters_Homo sapiens_hsa02010	0.67081495
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.66505511
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.64142452
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.60914637
60	Morphine addiction_Homo sapiens_hsa05032	0.60624770
61	Circadian entrainment_Homo sapiens_hsa04713	0.59164477
62	Pentose phosphate pathway_Homo sapiens_hsa00030	0.59103722
63	Amphetamine addiction_Homo sapiens_hsa05031	0.57910873
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57787344
65	Fatty acid degradation_Homo sapiens_hsa00071	0.57263294
66	Metabolic pathways_Homo sapiens_hsa01100	0.56423402
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.55459105
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54589622
69	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.52114079
70	Huntingtons disease_Homo sapiens_hsa05016	0.52040677
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51654607
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51347485
73	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50790827
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50141776
75	Cocaine addiction_Homo sapiens_hsa05030	0.49632775
76	Parkinsons disease_Homo sapiens_hsa05012	0.47246009
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.45856064
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.45219739
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.45059396
80	Peroxisome_Homo sapiens_hsa04146	0.44793633
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42268454
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41063949
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40558631
84	Alcoholism_Homo sapiens_hsa05034	0.40370875
85	Salivary secretion_Homo sapiens_hsa04970	0.39854259
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.39817544
87	Taste transduction_Homo sapiens_hsa04742	0.39315809
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.39138865
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38597479
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37638438
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.35589708
92	Renin secretion_Homo sapiens_hsa04924	0.34496377
93	Olfactory transduction_Homo sapiens_hsa04740	0.34411257
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.33430929
95	Bladder cancer_Homo sapiens_hsa05219	0.32889749
96	Alzheimers disease_Homo sapiens_hsa05010	0.32025336
97	Phototransduction_Homo sapiens_hsa04744	0.30571613
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29856154
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29668027
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27417790

GBAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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