GBE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen's disease). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.61400409
2L-phenylalanine catabolic process (GO:0006559)6.61400409
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.36579763
4L-phenylalanine metabolic process (GO:0006558)6.36579763
5aromatic amino acid family catabolic process (GO:0009074)5.89657773
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.73268945
7alpha-linolenic acid metabolic process (GO:0036109)5.71893109
8bile acid biosynthetic process (GO:0006699)5.29740039
9kynurenine metabolic process (GO:0070189)5.28571725
10indole-containing compound catabolic process (GO:0042436)5.27925019
11indolalkylamine catabolic process (GO:0046218)5.27925019
12tryptophan catabolic process (GO:0006569)5.27925019
13glyoxylate metabolic process (GO:0046487)5.24487528
14complement activation, alternative pathway (GO:0006957)5.06446601
15sulfur amino acid catabolic process (GO:0000098)5.02857417
16tryptophan metabolic process (GO:0006568)5.02397596
17urea metabolic process (GO:0019627)5.00988016
18urea cycle (GO:0000050)5.00988016
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98722222
20cysteine metabolic process (GO:0006534)4.98170778
21negative regulation of fibrinolysis (GO:0051918)4.90913803
22high-density lipoprotein particle remodeling (GO:0034375)4.85403544
23regulation of protein activation cascade (GO:2000257)4.81039126
24regulation of triglyceride catabolic process (GO:0010896)4.80614537
25protein carboxylation (GO:0018214)4.79624785
26peptidyl-glutamic acid carboxylation (GO:0017187)4.79624785
27lysine metabolic process (GO:0006553)4.77965874
28lysine catabolic process (GO:0006554)4.77965874
29low-density lipoprotein particle clearance (GO:0034383)4.75512068
30regulation of fibrinolysis (GO:0051917)4.66698871
31cell adhesion mediated by integrin (GO:0033627)4.61696337
32nitrogen cycle metabolic process (GO:0071941)4.61082456
33amino-acid betaine metabolic process (GO:0006577)4.53917187
34bile acid metabolic process (GO:0008206)4.53477943
35regulation of complement activation (GO:0030449)4.52456417
36serine family amino acid catabolic process (GO:0009071)4.47866282
37triglyceride homeostasis (GO:0070328)4.42289895
38acylglycerol homeostasis (GO:0055090)4.42289895
39tyrosine metabolic process (GO:0006570)4.39725660
40plasma lipoprotein particle clearance (GO:0034381)4.39166761
41aromatic amino acid family metabolic process (GO:0009072)4.34309183
42homocysteine metabolic process (GO:0050667)4.33440584
43plasma lipoprotein particle remodeling (GO:0034369)4.28349537
44protein-lipid complex remodeling (GO:0034368)4.28349537
45macromolecular complex remodeling (GO:0034367)4.28349537
46reverse cholesterol transport (GO:0043691)4.27775604
47alpha-amino acid catabolic process (GO:1901606)4.23804533
48skin morphogenesis (GO:0043589)4.23320785
49regulation of cholesterol esterification (GO:0010872)4.22633382
50cellular ketone body metabolic process (GO:0046950)4.22232700
51ethanol oxidation (GO:0006069)4.20490874
52endodermal cell differentiation (GO:0035987)4.17115674
53fatty acid beta-oxidation (GO:0006635)4.11911004
54acetyl-CoA metabolic process (GO:0006084)4.11247652
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.08378077
56phospholipid efflux (GO:0033700)4.06826182
57peptidyl-proline hydroxylation (GO:0019511)4.06267297
58Golgi transport vesicle coating (GO:0048200)4.03495126
59COPI coating of Golgi vesicle (GO:0048205)4.03495126
60protein hydroxylation (GO:0018126)4.02869585
61fatty acid oxidation (GO:0019395)3.99074036
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.97566691
63cellular amino acid catabolic process (GO:0009063)3.94617930
64valine metabolic process (GO:0006573)3.94555079
65coenzyme catabolic process (GO:0009109)3.92547291
66lipid oxidation (GO:0034440)3.92545767
67short-chain fatty acid metabolic process (GO:0046459)3.90980485
68bile acid and bile salt transport (GO:0015721)3.90564271
69positive regulation of lipid catabolic process (GO:0050996)3.90540243
702-oxoglutarate metabolic process (GO:0006103)3.90243671
71cellular glucuronidation (GO:0052695)3.88290271
72negative regulation of cholesterol transport (GO:0032375)3.88081111
73negative regulation of sterol transport (GO:0032372)3.88081111
74fatty acid catabolic process (GO:0009062)3.85495449
75fatty acid transmembrane transport (GO:1902001)3.84167103
76phospholipid homeostasis (GO:0055091)3.83894874
77retina vasculature morphogenesis in camera-type eye (GO:0061299)3.81765033
78collagen fibril organization (GO:0030199)3.80692109
79glycine metabolic process (GO:0006544)3.80403904
80monocarboxylic acid catabolic process (GO:0072329)3.78546804
81ketone body metabolic process (GO:1902224)3.76099747
82indolalkylamine metabolic process (GO:0006586)3.73542718
83cellular modified amino acid catabolic process (GO:0042219)3.72029497
84carboxylic acid catabolic process (GO:0046395)3.70776351
85organic acid catabolic process (GO:0016054)3.70776351
86regulation of plasminogen activation (GO:0010755)3.68188358
87glutamate metabolic process (GO:0006536)3.67600306
88serine family amino acid metabolic process (GO:0009069)3.66187080
89carnitine metabolic process (GO:0009437)3.66062241
90aldehyde catabolic process (GO:0046185)3.63463986
91benzene-containing compound metabolic process (GO:0042537)3.62746096
92low-density lipoprotein particle remodeling (GO:0034374)3.61625007
93cholesterol efflux (GO:0033344)3.61619194
94amine catabolic process (GO:0009310)3.61509869
95cellular biogenic amine catabolic process (GO:0042402)3.61509869
96negative regulation of lipase activity (GO:0060192)3.59898038
97plasma lipoprotein particle assembly (GO:0034377)3.59550481
98imidazole-containing compound metabolic process (GO:0052803)3.58779098
99protein heterotrimerization (GO:0070208)3.58107838
100dicarboxylic acid biosynthetic process (GO:0043650)3.57327353
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.55634598
102positive regulation of endothelial cell apoptotic process (GO:2000353)3.53387295
103fibrinolysis (GO:0042730)3.53106770
104aspartate family amino acid catabolic process (GO:0009068)3.49712631
105positive regulation of fatty acid oxidation (GO:0046321)3.47628460
106arginine metabolic process (GO:0006525)3.47146067
107positive regulation of triglyceride lipase activity (GO:0061365)3.46981811
108positive regulation of lipoprotein lipase activity (GO:0051006)3.46981811
109regulation of sequestering of triglyceride (GO:0010889)3.46411295
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.45574656
111carnitine shuttle (GO:0006853)3.45505524
112biotin metabolic process (GO:0006768)3.45031975
113regulation of cholesterol metabolic process (GO:0090181)3.44661181
114uronic acid metabolic process (GO:0006063)3.44456318
115glucuronate metabolic process (GO:0019585)3.44456318
116cholesterol homeostasis (GO:0042632)3.43846197
117apoptotic cell clearance (GO:0043277)3.42584011
118COPII vesicle coating (GO:0048208)3.42199748
119basement membrane organization (GO:0071711)3.33023662
120protein retention in ER lumen (GO:0006621)3.32321900
121muscle filament sliding (GO:0030049)3.29158266
122actin-myosin filament sliding (GO:0033275)3.29158266
123polyketide metabolic process (GO:0030638)3.20791039
124doxorubicin metabolic process (GO:0044598)3.20791039
125daunorubicin metabolic process (GO:0044597)3.20791039
126membrane raft organization (GO:0031579)3.19672094
127actin-mediated cell contraction (GO:0070252)3.14755648
128negative regulation of protein localization to plasma membrane (GO:1903077)3.14345118
129cell-substrate junction assembly (GO:0007044)3.13598781
130pinocytosis (GO:0006907)3.13446485
131negative regulation of fatty acid transport (GO:2000192)3.12640215
132hypotonic response (GO:0006971)3.11390547
133protein localization to endosome (GO:0036010)3.08543445
134hyaluronan catabolic process (GO:0030214)3.08156861
135NADH metabolic process (GO:0006734)3.06926717
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.06654307
1374-hydroxyproline metabolic process (GO:0019471)3.05370963
138sequestering of extracellular ligand from receptor (GO:0035581)3.03653977
139positive regulation of extracellular matrix organization (GO:1903055)2.98805253
140cell migration involved in heart development (GO:0060973)2.96185037
141blood vessel maturation (GO:0001955)2.95351776
142negative regulation of smooth muscle cell migration (GO:0014912)2.95256726
143chondrocyte proliferation (GO:0035988)2.94083130
144positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.93583246
145positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92588924
146fatty acid homeostasis (GO:0055089)2.91799474
147regulation of metalloenzyme activity (GO:0048552)2.90863442
148triglyceride catabolic process (GO:0019433)2.89476431
149type B pancreatic cell proliferation (GO:0044342)2.87884244
150stress fiber assembly (GO:0043149)2.87657074
151barbed-end actin filament capping (GO:0051016)2.87334928
152vascular endothelial growth factor signaling pathway (GO:0038084)2.84948076
153substrate-dependent cell migration (GO:0006929)2.83806721
154wound healing, spreading of epidermal cells (GO:0035313)2.83417208
155hemidesmosome assembly (GO:0031581)2.83386663
156cellular response to vitamin (GO:0071295)2.82525999
157regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.81980451
158aminoglycoside antibiotic metabolic process (GO:0030647)2.81101478
159extracellular fibril organization (GO:0043206)2.79628740
160regulation of integrin-mediated signaling pathway (GO:2001044)2.75476798
161glomerular basement membrane development (GO:0032836)2.74342659
162response to muscle activity (GO:0014850)2.73545503
163tricarboxylic acid cycle (GO:0006099)2.72997933
164protein maturation by protein folding (GO:0022417)2.72497648
165sarcomere organization (GO:0045214)2.72312631
166sprouting angiogenesis (GO:0002040)2.71998928
167platelet degranulation (GO:0002576)2.65816137
168endothelial cell morphogenesis (GO:0001886)2.64198117
169negative regulation of anoikis (GO:2000811)2.63533196
170collagen metabolic process (GO:0032963)2.62955251
171kidney mesenchyme development (GO:0072074)2.62182172
172vesicle coating (GO:0006901)2.57568447
173neutral lipid catabolic process (GO:0046461)2.56141702
174acylglycerol catabolic process (GO:0046464)2.56141702
175muscle cell cellular homeostasis (GO:0046716)2.53819557
176extracellular matrix disassembly (GO:0022617)2.51168755
177negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.50648839
178venous blood vessel morphogenesis (GO:0048845)2.50343438
179positive regulation of receptor recycling (GO:0001921)2.50124493
180tricarboxylic acid metabolic process (GO:0072350)2.49988467
181AMP metabolic process (GO:0046033)2.48482432
182protein localization to cell surface (GO:0034394)2.47248594
183positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46531075
184regulation of early endosome to late endosome transport (GO:2000641)2.46059453
185cardiac myofibril assembly (GO:0055003)2.45544473
186actin filament-based movement (GO:0030048)2.45383297
187fibril organization (GO:0097435)2.44991631
188focal adhesion assembly (GO:0048041)2.44681286
189cell-substrate adherens junction assembly (GO:0007045)2.44681286
190positive regulation of osteoblast proliferation (GO:0033690)2.43913079
191multicellular organismal macromolecule metabolic process (GO:0044259)2.43412445
192regulation of membrane protein ectodomain proteolysis (GO:0051043)2.42869928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.71743854
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.82717435
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.69538224
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.19453436
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.99934495
6TRIM28_21343339_ChIP-Seq_HEK293_Human4.91684122
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80237433
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66896917
9TP63_17297297_ChIP-ChIP_HaCaT_Human4.16636962
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76720548
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.62567083
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.15292688
13* HIF1A_21447827_ChIP-Seq_MCF-7_Human3.11838148
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.77095756
15* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.53313183
16* BRD4_25478319_ChIP-Seq_HGPS_Human2.36696126
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.33538589
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31428672
19CLOCK_20551151_ChIP-Seq_293T_Human2.18904985
20CJUN_26792858_Chip-Seq_BT549_Human2.17056093
21ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.07185157
22* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04410521
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03493162
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.02788716
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8412514
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98744619
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94220820
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94220820
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89387662
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.87735441
31GATA1_22025678_ChIP-Seq_K562_Human1.80795908
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80385856
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.77873878
34* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77119662
35* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.70220047
36* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65959691
37* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.64296312
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.64106065
39* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63320204
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.63058781
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60517591
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53177611
43AR_21909140_ChIP-Seq_LNCAP_Human1.52491798
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51089014
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47717655
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45255546
47* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.42576216
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42037810
49ATF3_27146783_Chip-Seq_COLON_Human1.35342892
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27798925
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26234240
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24899344
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24015462
54HTT_18923047_ChIP-ChIP_STHdh_Human1.21135378
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20014533
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16744614
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14959175
58* TP53_22127205_ChIP-Seq_IMR90_Human1.14478408
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14418710
60* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13336189
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12241036
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10553465
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09553996
64TP53_18474530_ChIP-ChIP_U2OS_Human1.07470164
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06685501
66SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06521694
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04923948
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04570981
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02779339
70TP53_16413492_ChIP-PET_HCT116_Human1.01719288
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98155770
72RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97558076
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96509093
74* TFEB_21752829_ChIP-Seq_HELA_Human0.96237801
75SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95148788
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94875023
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93774175
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93087618
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91884525
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90738199
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.89998465
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89726978
83ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89302229
84ZNF263_19887448_ChIP-Seq_K562_Human0.88206576
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87384822
86* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86713865
87* GATA4_25053715_ChIP-Seq_YYC3_Human0.84875623
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84125228
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83648278
90SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82995461
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81961045
92SA1_22415368_ChIP-Seq_MEFs_Mouse0.79894825
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79648966
94NFI_21473784_ChIP-Seq_ESCs_Mouse0.79033471
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78929626
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78555180
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78162194
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78055277
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76153033
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.75974866
101PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.75898162
102SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75516259
103* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74338375
104* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74338375
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73830379
106ESR2_21235772_ChIP-Seq_MCF-7_Human0.73204342
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69883865
108BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69005829
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68660716
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.67574901
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.67574901
112* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66634224
113EGR1_19032775_ChIP-ChIP_M12_Human0.64794908
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64453172
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63856366
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63574201
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62921092
118* CEBPB_22108803_ChIP-Seq_LS180_Human0.62844114
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.62820489
120* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61123786
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.58758197
122GATA2_19941826_ChIP-Seq_K562_Human0.58698174
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57291477
124IRF8_27001747_Chip-Seq_BMDM_Mouse0.57041262
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56686336
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.56393093
127GATA1_19941826_ChIP-Seq_K562_Human0.56023472
128* AR_20517297_ChIP-Seq_VCAP_Human0.55783363
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54653765
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.53444401
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.53029200
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52961201
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.52334264
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.50209584
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.48793031
136LXR_22292898_ChIP-Seq_THP-1_Human0.48333573
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.47430430
138* RARB_24833708_ChIP-Seq_LIVER_Mouse0.47372951
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.47314723
140CBP_21632823_ChIP-Seq_H3396_Human0.47112891
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.46578793
142* SOX2_20726797_ChIP-Seq_SW620_Human0.46048222
143GATA6_25053715_ChIP-Seq_YYC3_Human0.45299508
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.44873812
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.44683865
146GATA1_22383799_ChIP-Seq_G1ME_Mouse0.44578534
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.44332305
148* ERG_20517297_ChIP-Seq_VCAP_Human0.43599892
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42903284
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.42429685
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.42032169
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.41702480
153SCL_19346495_ChIP-Seq_HPC-7_Human0.40730839
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.40546362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.53591981
2MP0005360_urolithiasis6.59147720
3MP0008438_abnormal_cutaneous_collagen6.41182774
4MP0005365_abnormal_bile_salt5.82650344
5MP0005085_abnormal_gallbladder_physiolo5.70472869
6MP0008875_abnormal_xenobiotic_pharmacok4.53460441
7MP0003806_abnormal_nucleotide_metabolis3.88249188
8MP0004272_abnormal_basement_membrane3.74416186
9MP0003950_abnormal_plasma_membrane3.68155673
10MP0010329_abnormal_lipoprotein_level3.55909756
11MP0003252_abnormal_bile_duct3.51395730
12MP0009840_abnormal_foam_cell3.13650828
13MP0005275_abnormal_skin_tensile2.85046063
14MP0003279_aneurysm2.77205920
15MP0005083_abnormal_biliary_tract2.76907525
16MP0000751_myopathy2.76188747
17MP0005332_abnormal_amino_acid2.62838144
18MP0003566_abnormal_cell_adhesion2.51500012
19MP0003191_abnormal_cellular_cholesterol2.41101490
20MP0003195_calcinosis2.40726228
21MP0001958_emphysema2.34223932
22MP0001666_abnormal_nutrient_absorption2.30230542
23MP0000749_muscle_degeneration2.26057977
24MP0000609_abnormal_liver_physiology2.25203778
25MP0002877_abnormal_melanocyte_morpholog2.25123402
26MP0002118_abnormal_lipid_homeostasis2.22371891
27MP0005623_abnormal_meninges_morphology2.09589815
28MP0005257_abnormal_intraocular_pressure2.07335588
29MP0005503_abnormal_tendon_morphology2.06455353
30MP0004084_abnormal_cardiac_muscle2.04497759
31MP0000013_abnormal_adipose_tissue1.95483066
32MP0005319_abnormal_enzyme/_coenzyme1.93557733
33MP0005670_abnormal_white_adipose1.87755296
34MP0006054_spinal_hemorrhage1.84568753
35MP0004019_abnormal_vitamin_homeostasis1.79991522
36MP0003091_abnormal_cell_migration1.79250728
37MP0004130_abnormal_muscle_cell1.78989104
38MP0005023_abnormal_wound_healing1.76363819
39MP0002138_abnormal_hepatobiliary_system1.74919151
40MP0004233_abnormal_muscle_weight1.73122037
41MP0005584_abnormal_enzyme/coenzyme_acti1.71396881
42MP0003868_abnormal_feces_composition1.70824870
43MP0010352_gastrointestinal_tract_polyps1.69716751
44MP0009780_abnormal_chondrocyte_physiolo1.66364578
45MP0000759_abnormal_skeletal_muscle1.63772446
46MP0000747_muscle_weakness1.62190456
47MP0001764_abnormal_homeostasis1.60443025
48MP0003186_abnormal_redox_activity1.58844823
49MP0009697_abnormal_copulation1.54973481
50MP0000767_abnormal_smooth_muscle1.53102709
51MP0002060_abnormal_skin_morphology1.50169468
52MP0003011_delayed_dark_adaptation1.49217313
53MP0000003_abnormal_adipose_tissue1.47734214
54MP0002837_dystrophic_cardiac_calcinosis1.43941147
55MP0006036_abnormal_mitochondrial_physio1.38723963
56MP0000733_abnormal_muscle_development1.38685327
57MP0005451_abnormal_body_composition1.35589290
58MP0002971_abnormal_brown_adipose1.34648854
59MP0005666_abnormal_adipose_tissue1.33482751
60MP0001542_abnormal_bone_strength1.32766709
61MP0009643_abnormal_urine_homeostasis1.31699438
62MP0000750_abnormal_muscle_regeneration1.28153949
63MP0003828_pulmonary_edema1.27432021
64MP0005165_increased_susceptibility_to1.27068584
65MP0003941_abnormal_skin_development1.25859681
66MP0006138_congestive_heart_failure1.25771628
67MP0008775_abnormal_heart_ventricle1.25541272
68MP0005164_abnormal_response_to1.23032590
69MP0000598_abnormal_liver_morphology1.22790470
70MP0002295_abnormal_pulmonary_circulatio1.19645865
71MP0002108_abnormal_muscle_morphology1.16840741
72MP0002106_abnormal_muscle_physiology1.16739076
73MP0003656_abnormal_erythrocyte_physiolo1.16431478
74MP0003705_abnormal_hypodermis_morpholog1.15428503
75MP0002896_abnormal_bone_mineralization1.14679934
76MP0002972_abnormal_cardiac_muscle1.12427256
77MP0009763_increased_sensitivity_to1.11157252
78MP0001879_abnormal_lymphatic_vessel1.11068926
79MP0009764_decreased_sensitivity_to1.10516388
80MP0002254_reproductive_system_inflammat1.06839574
81MP0005369_muscle_phenotype1.06443169
82MP0001915_intracranial_hemorrhage1.05044563
83MP0005334_abnormal_fat_pad1.04476048
84MP0005620_abnormal_muscle_contractility1.01544273
85MP0001243_abnormal_dermal_layer1.01482122
86MP0008469_abnormal_protein_level1.00487956
87MP0002078_abnormal_glucose_homeostasis0.99929932
88MP0004145_abnormal_muscle_electrophysio0.99468003
89MP0000604_amyloidosis0.96890021
90MP0010368_abnormal_lymphatic_system0.96085121
91MP0004510_myositis0.95960841
92MP0005535_abnormal_body_temperature0.95960582
93MP0005508_abnormal_skeleton_morphology0.92822726
94MP0005647_abnormal_sex_gland0.92654753
95MP0003724_increased_susceptibility_to0.92596072
96MP0005171_absent_coat_pigmentation0.90905447
97MP0005408_hypopigmentation0.89299385
98MP0001299_abnormal_eye_distance/0.88955758
99MP0009642_abnormal_blood_homeostasis0.88240436
100MP0002128_abnormal_blood_circulation0.85611026
101MP0005636_abnormal_mineral_homeostasis0.84168301
102MP0005595_abnormal_vascular_smooth0.83977520
103MP0010630_abnormal_cardiac_muscle0.83536587
104MP0005376_homeostasis/metabolism_phenot0.80428277
105MP0003646_muscle_fatigue0.79093253
106MP0006035_abnormal_mitochondrial_morpho0.78194963
107MP0001661_extended_life_span0.77080177
108MP0004185_abnormal_adipocyte_glucose0.76294116
109MP0004215_abnormal_myocardial_fiber0.75748672
110MP0000858_altered_metastatic_potential0.74700113
111MP0009115_abnormal_fat_cell0.74190669
112MP0005266_abnormal_metabolism0.73504675
113MP0005058_abnormal_lysosome_morphology0.72563493
114MP0005375_adipose_tissue_phenotype0.71863315
115MP0001614_abnormal_blood_vessel0.71060039
116MP0002876_abnormal_thyroid_physiology0.69857633
117MP0009250_abnormal_appendicular_skeleto0.69653647
118MP0005448_abnormal_energy_balance0.69639577
119MP0005464_abnormal_platelet_physiology0.69626260
120MP0003436_decreased_susceptibility_to0.69209266
121MP0005084_abnormal_gallbladder_morpholo0.69057798
122MP0004484_altered_response_of0.68658449
123MP0005330_cardiomyopathy0.68640630
124MP0005220_abnormal_exocrine_pancreas0.68633046
125MP0001853_heart_inflammation0.68572693
126MP0009765_abnormal_xenobiotic_induced0.67747813
127MP0005197_abnormal_uvea_morphology0.67527915
128MP0002166_altered_tumor_susceptibility0.65496782
129MP0002970_abnormal_white_adipose0.64976146
130MP0003690_abnormal_glial_cell0.63400024
131MP0002168_other_aberrant_phenotype0.61948106
132MP0002998_abnormal_bone_remodeling0.61466513
133MP0001756_abnormal_urination0.61055767
134MP0003448_altered_tumor_morphology0.60935235
135MP0003045_fibrosis0.60101157
136MP0003221_abnormal_cardiomyocyte_apopto0.53114410
137MP0002269_muscular_atrophy0.50589046
138MP0009785_altered_susceptibility_to0.50227640
139MP0000249_abnormal_blood_vessel0.49501225
140MP0002136_abnormal_kidney_physiology0.48869934
141MP0003329_amyloid_beta_deposits0.47041178
142MP0000343_altered_response_to0.45968642
143MP0000230_abnormal_systemic_arterial0.45228071
144MP0003953_abnormal_hormone_level0.44998846
145MP0001845_abnormal_inflammatory_respons0.43818642
146MP0003075_altered_response_to0.43017660
147MP0001881_abnormal_mammary_gland0.42952471
148MP0002928_abnormal_bile_duct0.42910205
149MP0008873_increased_physiological_sensi0.42797514
150MP0004036_abnormal_muscle_relaxation0.42451526
151MP0004782_abnormal_surfactant_physiolog0.42402720
152MP0003959_abnormal_lean_body0.42359513
153MP0001544_abnormal_cardiovascular_syste0.42254713
154MP0005385_cardiovascular_system_phenoty0.42254713
155MP0000639_abnormal_adrenal_gland0.42059619
156MP0009384_cardiac_valve_regurgitation0.41968897
157MP0004087_abnormal_muscle_fiber0.40858860
158MP0002332_abnormal_exercise_endurance0.39856063
159MP0003300_gastrointestinal_ulcer0.39734299
160MP0006082_CNS_inflammation0.39546355
161MP0003638_abnormal_response/metabolism_0.39270380
162MP0005166_decreased_susceptibility_to0.38047925
163MP0005167_abnormal_blood-brain_barrier0.37791552
164MP0009672_abnormal_birth_weight0.36798895

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.40037585
2Protrusio acetabuli (HP:0003179)6.39567284
3Premature rupture of membranes (HP:0001788)6.36443148
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30047556
5Intrahepatic cholestasis (HP:0001406)6.29632208
6Xanthomatosis (HP:0000991)5.73827209
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.59092556
8Prolonged partial thromboplastin time (HP:0003645)5.57798346
9Hypobetalipoproteinemia (HP:0003563)5.53260081
10Hyperlipoproteinemia (HP:0010980)5.12519865
11Type 1 muscle fiber predominance (HP:0003803)5.07009768
12Complement deficiency (HP:0004431)4.85695001
13Hyperammonemia (HP:0001987)4.70458377
14Hypoglycemic coma (HP:0001325)4.68437497
15Hypolipoproteinemia (HP:0010981)4.46005818
16Ketosis (HP:0001946)4.42347295
17Hyperglycinuria (HP:0003108)4.27262896
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.23050610
19Hyperglycinemia (HP:0002154)4.22322056
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19075897
21Nemaline bodies (HP:0003798)4.16742767
22Epidermoid cyst (HP:0200040)4.16670671
23Joint hemorrhage (HP:0005261)4.15978963
24Muscle fiber inclusion bodies (HP:0100299)4.12875038
25Hypoalphalipoproteinemia (HP:0003233)4.12021294
26Abnormality of glycine metabolism (HP:0010895)4.07636079
27Abnormality of serine family amino acid metabolism (HP:0010894)4.07636079
28Abnormality of the common coagulation pathway (HP:0010990)4.07373258
29Aortic dissection (HP:0002647)4.04216954
30Abnormality of fatty-acid metabolism (HP:0004359)4.04011801
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.82779916
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82466574
33Vascular tortuosity (HP:0004948)3.78734322
34Vertebral compression fractures (HP:0002953)3.78673559
35Aortic aneurysm (HP:0004942)3.76940354
36Abnormality of methionine metabolism (HP:0010901)3.72141043
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.69987070
38Spinal rigidity (HP:0003306)3.61290524
39Ketoacidosis (HP:0001993)3.59672243
40Arterial tortuosity (HP:0005116)3.58401415
41Abnormality of sulfur amino acid metabolism (HP:0004339)3.58056050
42Fat malabsorption (HP:0002630)3.57227301
43Increased variability in muscle fiber diameter (HP:0003557)3.56575534
44Abnormality of the intrinsic pathway (HP:0010989)3.53828684
45Abnormality of complement system (HP:0005339)3.50979923
46Abnormality of skeletal muscle fiber size (HP:0012084)3.45904978
47Ankle contracture (HP:0006466)3.41103734
48Hypercholesterolemia (HP:0003124)3.39454264
49Follicular hyperkeratosis (HP:0007502)3.29056985
50Dicarboxylic aciduria (HP:0003215)3.25836383
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25836383
52Increased connective tissue (HP:0009025)3.25032356
53Wormian bones (HP:0002645)3.16645160
54Abnormality of serum amino acid levels (HP:0003112)3.07733468
55Hyperbilirubinemia (HP:0002904)3.05722855
56Abnormality of pyrimidine metabolism (HP:0004353)3.05054635
57Mildly elevated creatine phosphokinase (HP:0008180)3.04296245
58Conjugated hyperbilirubinemia (HP:0002908)3.02317926
59Cervical subluxation (HP:0003308)3.01823271
60Slender build (HP:0001533)3.01801177
61Osteolytic defects of the hand bones (HP:0009699)2.94819589
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.94819589
63Metabolic acidosis (HP:0001942)2.89218348
64Exercise-induced myalgia (HP:0003738)2.88199567
65Skin nodule (HP:0200036)2.85869025
66Abnormality of nucleobase metabolism (HP:0010932)2.81064030
67Soft skin (HP:0000977)2.79074806
68Bladder diverticulum (HP:0000015)2.77587071
69Abnormal gallbladder physiology (HP:0012438)2.75452556
70Cholecystitis (HP:0001082)2.75452556
71Hepatocellular carcinoma (HP:0001402)2.75050491
72Lethargy (HP:0001254)2.74843130
73Myocardial infarction (HP:0001658)2.74566795
74Myoglobinuria (HP:0002913)2.70525395
75Hyporeflexia of lower limbs (HP:0002600)2.70192231
76Atrophic scars (HP:0001075)2.69431625
77Generalized aminoaciduria (HP:0002909)2.69392343
78Abnormality of purine metabolism (HP:0004352)2.69068727
79Hypoglycemic seizures (HP:0002173)2.68958326
80Steatorrhea (HP:0002570)2.68502369
81Delayed CNS myelination (HP:0002188)2.66972230
82Systemic lupus erythematosus (HP:0002725)2.66813442
83Spondylolisthesis (HP:0003302)2.65386599
84Cerebral edema (HP:0002181)2.60132474
85Dilatation of the ascending aorta (HP:0005111)2.59832425
86Distal lower limb muscle weakness (HP:0009053)2.59003955
87Round ear (HP:0100830)2.58303265
88Cerebral aneurysm (HP:0004944)2.56663293
89Abnormal gallbladder morphology (HP:0012437)2.53752245
90Reduced subcutaneous adipose tissue (HP:0003758)2.52926063
91Blue sclerae (HP:0000592)2.51291463
92Neck muscle weakness (HP:0000467)2.50468936
93Elbow flexion contracture (HP:0002987)2.49299182
94Distal lower limb amyotrophy (HP:0008944)2.49053940
95Cholelithiasis (HP:0001081)2.48262240
96Recurrent gram-negative bacterial infections (HP:0005420)2.46180249
97Abnormality of dentin (HP:0010299)2.43039477
98Exercise-induced muscle cramps (HP:0003710)2.38724515
99Asymmetric septal hypertrophy (HP:0001670)2.35263844
100Acanthocytosis (HP:0001927)2.34978002
101Fragile skin (HP:0001030)2.33561177
102Late onset (HP:0003584)2.32847691
103EMG: myopathic abnormalities (HP:0003458)2.32570331
104Renal cortical cysts (HP:0000803)2.30480918
105Hyperinsulinemic hypoglycemia (HP:0000825)2.30421158
106Abnormality of the acetabulum (HP:0003170)2.29936763
107Rhabdomyolysis (HP:0003201)2.29658441
108Abnormality of the calf musculature (HP:0001430)2.28716131
109Spontaneous abortion (HP:0005268)2.28049695
110Hypochromic microcytic anemia (HP:0004840)2.23572909
111Vascular calcification (HP:0004934)2.23457418
112Pancreatitis (HP:0001733)2.23080323
113Hydroxyprolinuria (HP:0003080)2.22965080
114Abnormality of proline metabolism (HP:0010907)2.22965080
115Lipoatrophy (HP:0100578)2.22839859
116Spastic diplegia (HP:0001264)2.21944787
117Vomiting (HP:0002013)2.21914805
118Generalized amyotrophy (HP:0003700)2.21596885
119Gout (HP:0001997)2.18606672
120Abnormal delivery (HP:0001787)2.16317415
121Glomerulonephritis (HP:0000099)2.15934734
122Peritonitis (HP:0002586)2.15712748
123Proximal tubulopathy (HP:0000114)2.15666933
124Centrally nucleated skeletal muscle fibers (HP:0003687)2.14660919
125Muscle fiber splitting (HP:0003555)2.14098965
126Hypertriglyceridemia (HP:0002155)2.13806218
127Nausea (HP:0002018)2.13804827
128Irritability (HP:0000737)2.12922436
129Abnormality of glycolysis (HP:0004366)2.10453959
130Aneurysm (HP:0002617)2.10303976
131Ulnar deviation of the wrist (HP:0003049)2.09474493
132Neonatal onset (HP:0003623)2.09437870
133Brushfield spots (HP:0001088)2.09047983
134Glucose intolerance (HP:0000833)2.08001780
135Back pain (HP:0003418)2.07803514
136Mitral valve prolapse (HP:0001634)2.07711202
137Sensorimotor neuropathy (HP:0007141)2.06809423
138Short nail (HP:0001799)2.05662104
139Gingival bleeding (HP:0000225)2.04304829
140Abnormal cartilage morphology (HP:0002763)2.03245038
141Mitral stenosis (HP:0001718)2.02495731
142Hyperglycemia (HP:0003074)2.01761604
143Ovoid vertebral bodies (HP:0003300)2.00437715
144Amyloidosis (HP:0011034)2.00262482
145Cardiovascular calcification (HP:0011915)1.99856816
146Hemorrhage of the eye (HP:0011885)1.99630229
147Abnormality of the gallbladder (HP:0005264)1.98941762
148Menorrhagia (HP:0000132)1.98622080
149Achilles tendon contracture (HP:0001771)1.98167214
150Abnormality of the Achilles tendon (HP:0005109)1.97427008
151Muscle stiffness (HP:0003552)1.96655730
152Limb-girdle muscle atrophy (HP:0003797)1.96126802
153Mitral regurgitation (HP:0001653)1.95095737
154* Esophageal varix (HP:0002040)1.94539469
155Wrist flexion contracture (HP:0001239)1.93375055
156Elevated hepatic transaminases (HP:0002910)1.92363236
157Shallow orbits (HP:0000586)1.92233972
158Delayed closure of the anterior fontanelle (HP:0001476)1.90396804
159Limb-girdle muscle weakness (HP:0003325)1.89909769
160Abnormality of iron homeostasis (HP:0011031)1.89396006
161Thrombophlebitis (HP:0004418)1.89146295
162Overgrowth (HP:0001548)1.89005096
163Biconcave vertebral bodies (HP:0004586)1.88603404
164Scapular winging (HP:0003691)1.87022121
165Increased serum pyruvate (HP:0003542)1.85567955
166Abnormality of transition element cation homeostasis (HP:0011030)1.85185458
167Enlarged kidneys (HP:0000105)1.84568963
168Malnutrition (HP:0004395)1.83496146
169Bowel diverticulosis (HP:0005222)1.82247285
170Hepatic necrosis (HP:0002605)1.81782667
171Glycosuria (HP:0003076)1.81657335
172Abnormality of urine glucose concentration (HP:0011016)1.81657335
173Genu recurvatum (HP:0002816)1.80983151
174Aortic regurgitation (HP:0001659)1.80662092
175Opisthotonus (HP:0002179)1.80185338
176Disproportionate tall stature (HP:0001519)1.79969088
177Neonatal short-limb short stature (HP:0008921)1.76658647
178Joint laxity (HP:0001388)1.76137496
179Lower limb amyotrophy (HP:0007210)1.75307060
180Acanthosis nigricans (HP:0000956)1.74737531
181Difficulty climbing stairs (HP:0003551)1.72884238
182Distal upper limb amyotrophy (HP:0007149)1.71537270
183Upper limb amyotrophy (HP:0009129)1.71537270
184Distal arthrogryposis (HP:0005684)1.69636611
185Abnormality of carpal bone ossification (HP:0006257)1.69607117
186Joint stiffness (HP:0001387)1.69188720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.18983869
2SIK14.00592210
3ERN13.52110815
4TRIB33.24632213
5PKN23.08074760
6FGFR43.01017494
7INSRR2.93545046
8FLT32.65180733
9DDR22.44846851
10MST1R2.33754691
11MOS2.19070535
12LATS22.16817466
13TAOK32.15274464
14OBSCN2.09344889
15SCYL22.08316389
16EIF2AK32.02323804
17PIK3CG2.01107770
18CAMK1D1.93162198
19EIF2AK11.88895035
20TRPM71.84872380
21ERBB41.84759210
22LIMK11.78964958
23MAP2K31.76938265
24NEK91.74091429
25PDK31.72906814
26PDK41.72906814
27PAK21.72383179
28TYK21.67723116
29MAPK111.55263601
30ARAF1.53229760
31KDR1.52621884
32PRKAA21.50681105
33MAP2K41.41209193
34ICK1.38690721
35TBK11.38448145
36FRK1.35279467
37MAP3K31.34747598
38PAK41.33613625
39SMG11.30106207
40PIM21.29729548
41PTK61.29621698
42TTN1.26736741
43TIE11.23278950
44TESK11.21388091
45LATS11.19491872
46CDK81.18170043
47PINK11.15864692
48JAK11.15773158
49ABL21.11649373
50EEF2K1.10737830
51MAP3K71.09882463
52NTRK11.08423106
53PRPF4B1.07413599
54JAK21.03496149
55IRAK31.03482468
56RIPK10.99888491
57TGFBR20.98085893
58CAMK1G0.96559747
59NME20.95838965
60PDGFRB0.94240183
61MAP3K140.93157361
62PDK20.90466302
63MET0.84741951
64FGFR30.84049912
65EPHB20.82315535
66PRKAA10.80383021
67MAPK40.80333271
68MAP3K60.76970085
69MAPK120.75573736
70MYLK0.74342857
71TGFBR10.74188356
72EPHB10.74147849
73KSR20.73970139
74CDK60.72383727
75IKBKE0.71927466
76EPHA20.70538737
77DAPK30.70384563
78MAP3K50.70254493
79LMTK20.69787208
80CSF1R0.69674530
81STK380.67579968
82MAP3K120.67328247
83MAPK70.66950440
84JAK30.65732514
85PHKG20.64948693
86PHKG10.64948693
87MAP2K60.64739999
88CSK0.63628193
89MAP3K110.63272977
90GSK3A0.62829487
91KIT0.62408067
92PRKACG0.61133234
93MAP3K100.59942294
94PIK3CA0.58079585
95ILK0.57707531
96EPHA30.57539710
97ACVR1B0.54093044
98CDK90.53819170
99PDPK10.53814610
100MAPKAPK50.53646344
101ROCK20.53553345
102MAP2K10.53135645
103MUSK0.51741889
104ZAP700.51100934
105AKT20.50633759
106STK38L0.49806848
107IGF1R0.49531265
108STK30.49524311
109ROCK10.48984349
110FGFR20.48940475
111RAF10.48862759
112MAP4K10.48761299
113GRK60.47362366
114ERBB30.47099989
115NEK10.46615999
116PAK60.45339793
117FER0.44803967
118PDK10.44320216
119DAPK20.44291154
120CAMK2G0.44006762
121CDC42BPA0.43640924
122CDK40.43293202
123WNK10.43011610
124SGK30.41032133
125ERBB20.40604232
126MELK0.39894064
127RET0.39687595
128DYRK1B0.39254417
129PTK2B0.39115993
130DMPK0.38371517
131CLK10.38105966
132PRKCZ0.37989915
133MAP3K80.37970639
134TAOK20.37735412
135MAPK150.36499389
136BTK0.34065219
137PDGFRA0.32599067
138PTK20.32559152
139TEC0.32386724
140MAP3K130.31965457
141MAPKAPK30.31657475
142PRKG20.31397355
143IRAK40.31067022
144PRKCQ0.31051841
145ITK0.30947133
146LRRK20.30688056
147EGFR0.30532846
148MTOR0.27977335

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06496286
2Nitrogen metabolism_Homo sapiens_hsa009103.29202430
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10327978
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03422361
5Fatty acid degradation_Homo sapiens_hsa000712.95093862
6ECM-receptor interaction_Homo sapiens_hsa045122.87377502
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.81385507
8Arginine biosynthesis_Homo sapiens_hsa002202.78616737
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69079599
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62881600
11Propanoate metabolism_Homo sapiens_hsa006402.59786714
12Tryptophan metabolism_Homo sapiens_hsa003802.57318030
13Complement and coagulation cascades_Homo sapiens_hsa046102.50895244
14Fatty acid metabolism_Homo sapiens_hsa012122.31869830
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25033652
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.22695341
17PPAR signaling pathway_Homo sapiens_hsa033202.20040069
18Focal adhesion_Homo sapiens_hsa045102.17423533
19Peroxisome_Homo sapiens_hsa041462.15897848
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13756342
21Butanoate metabolism_Homo sapiens_hsa006502.12522000
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.10114345
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98657226
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94314877
25Dilated cardiomyopathy_Homo sapiens_hsa054141.88633695
26Caffeine metabolism_Homo sapiens_hsa002321.83735819
27beta-Alanine metabolism_Homo sapiens_hsa004101.76015941
28Chemical carcinogenesis_Homo sapiens_hsa052041.75252814
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73699697
30Staphylococcus aureus infection_Homo sapiens_hsa051501.72014842
31Pyruvate metabolism_Homo sapiens_hsa006201.68695823
32Histidine metabolism_Homo sapiens_hsa003401.63300607
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.61586519
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.59119159
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57155798
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56786815
37Fatty acid elongation_Homo sapiens_hsa000621.55624409
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55620462
39Carbon metabolism_Homo sapiens_hsa012001.55063710
40Selenocompound metabolism_Homo sapiens_hsa004501.52656535
41Other glycan degradation_Homo sapiens_hsa005111.52497301
42Retinol metabolism_Homo sapiens_hsa008301.52158111
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50116288
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48551986
45Phenylalanine metabolism_Homo sapiens_hsa003601.45615032
46Proteoglycans in cancer_Homo sapiens_hsa052051.44294733
47Tyrosine metabolism_Homo sapiens_hsa003501.38212658
48* Starch and sucrose metabolism_Homo sapiens_hsa005001.34132977
49Small cell lung cancer_Homo sapiens_hsa052221.34067895
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33207910
51Sulfur metabolism_Homo sapiens_hsa009201.32066084
52Biosynthesis of amino acids_Homo sapiens_hsa012301.29750262
53Bile secretion_Homo sapiens_hsa049761.27669498
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23372766
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20682163
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.17540785
57Fat digestion and absorption_Homo sapiens_hsa049751.17427695
58ABC transporters_Homo sapiens_hsa020101.17214287
59Bladder cancer_Homo sapiens_hsa052191.10613128
60Folate biosynthesis_Homo sapiens_hsa007901.09159248
61Fatty acid biosynthesis_Homo sapiens_hsa000611.03445550
62Protein digestion and absorption_Homo sapiens_hsa049741.03020423
63Adherens junction_Homo sapiens_hsa045200.95779438
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95270093
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91531350
66Pentose phosphate pathway_Homo sapiens_hsa000300.89480186
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88504043
68Steroid biosynthesis_Homo sapiens_hsa001000.87433924
69Sulfur relay system_Homo sapiens_hsa041220.86881705
70N-Glycan biosynthesis_Homo sapiens_hsa005100.86742256
71Glycerolipid metabolism_Homo sapiens_hsa005610.86333460
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.84962378
73Arginine and proline metabolism_Homo sapiens_hsa003300.84084474
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80818979
75Lysine degradation_Homo sapiens_hsa003100.80703015
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79465759
77Chronic myeloid leukemia_Homo sapiens_hsa052200.78431681
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76028733
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74298277
80Vitamin B6 metabolism_Homo sapiens_hsa007500.72480997
81HIF-1 signaling pathway_Homo sapiens_hsa040660.72168564
82Vitamin digestion and absorption_Homo sapiens_hsa049770.71216725
83Glutathione metabolism_Homo sapiens_hsa004800.67328691
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66392073
85Pancreatic cancer_Homo sapiens_hsa052120.65399321
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.63035378
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61457507
88Melanoma_Homo sapiens_hsa052180.59449705
89Shigellosis_Homo sapiens_hsa051310.56839126
90p53 signaling pathway_Homo sapiens_hsa041150.55996630
91One carbon pool by folate_Homo sapiens_hsa006700.54421914
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.53728592
93Thyroid cancer_Homo sapiens_hsa052160.50946966
94Insulin resistance_Homo sapiens_hsa049310.50626554
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47211652
96* Metabolic pathways_Homo sapiens_hsa011000.47034197
97Fructose and mannose metabolism_Homo sapiens_hsa000510.45458332
98TGF-beta signaling pathway_Homo sapiens_hsa043500.44379460
99MicroRNAs in cancer_Homo sapiens_hsa052060.43167216
100Galactose metabolism_Homo sapiens_hsa000520.40415984
101Viral myocarditis_Homo sapiens_hsa054160.37983092
102Toxoplasmosis_Homo sapiens_hsa051450.36225302
103Renal cell carcinoma_Homo sapiens_hsa052110.35193497
104Circadian rhythm_Homo sapiens_hsa047100.34780548
105Pathways in cancer_Homo sapiens_hsa052000.32524571
106Glioma_Homo sapiens_hsa052140.29857628
107Glucagon signaling pathway_Homo sapiens_hsa049220.28915677
108Hepatitis B_Homo sapiens_hsa051610.27563893
109AMPK signaling pathway_Homo sapiens_hsa041520.26729486
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24855354
111Prion diseases_Homo sapiens_hsa050200.22948485
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19127577
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.17068289
114Insulin signaling pathway_Homo sapiens_hsa049100.12995427
115Linoleic acid metabolism_Homo sapiens_hsa005910.11965791
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05984320
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.05457585
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.01055857
119Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2073123
120Malaria_Homo sapiens_hsa05144-0.1933839
121Renin-angiotensin system_Homo sapiens_hsa04614-0.1902515
122Amoebiasis_Homo sapiens_hsa05146-0.1703590
123Lysosome_Homo sapiens_hsa04142-0.1670655
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1567441
125Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1567093
126Regulation of autophagy_Homo sapiens_hsa04140-0.1527753
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1489314
128Pertussis_Homo sapiens_hsa05133-0.1405667
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1277329
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1232205
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1207265
132Hepatitis C_Homo sapiens_hsa05160-0.1097145
133Legionellosis_Homo sapiens_hsa05134-0.0997100
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0769063
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0385387

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