GBF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* COPI coating of Golgi vesicle (GO:0048205)5.55486795
2* Golgi transport vesicle coating (GO:0048200)5.55486795
3COPII vesicle coating (GO:0048208)4.36487874
4activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.07883961
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.06434528
6cell-substrate junction assembly (GO:0007044)3.94615266
7adherens junction assembly (GO:0034333)3.93143402
8focal adhesion assembly (GO:0048041)3.92623179
9cell-substrate adherens junction assembly (GO:0007045)3.92623179
10positive regulation of nuclease activity (GO:0032075)3.81989183
11protein localization to endosome (GO:0036010)3.81724275
12* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.80081310
13protein retention in ER lumen (GO:0006621)3.65747710
14macroautophagy (GO:0016236)3.61806315
15hemidesmosome assembly (GO:0031581)3.59100177
16desmosome organization (GO:0002934)3.49167316
17skin morphogenesis (GO:0043589)3.41477160
18* vesicle coating (GO:0006901)3.41046517
19regulation of nuclease activity (GO:0032069)3.38938064
20basement membrane organization (GO:0071711)3.35044979
21endoplasmic reticulum unfolded protein response (GO:0030968)3.33349242
22cellular response to unfolded protein (GO:0034620)3.26212502
23regulation of cholesterol homeostasis (GO:2000188)3.24051379
24protein targeting to Golgi (GO:0000042)3.23071095
25ER-nucleus signaling pathway (GO:0006984)3.20054287
26negative regulation of cell size (GO:0045792)3.17265148
27insulin-like growth factor receptor signaling pathway (GO:0048009)3.15488122
28regulation of early endosome to late endosome transport (GO:2000641)3.15006934
29activation of Rac GTPase activity (GO:0032863)3.13383286
30positive regulation of glycogen biosynthetic process (GO:0045725)3.13310914
31epithelial cell-cell adhesion (GO:0090136)3.10153526
32establishment of protein localization to Golgi (GO:0072600)3.06842653
33exocrine pancreas development (GO:0031017)3.04291196
34cellular response to topologically incorrect protein (GO:0035967)3.04201110
35barbed-end actin filament capping (GO:0051016)3.03736526
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01932146
37semaphorin-plexin signaling pathway (GO:0071526)3.00008725
38regulation of fatty acid beta-oxidation (GO:0031998)2.99012689
39retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95502506
40type B pancreatic cell development (GO:0003323)2.95057059
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92039907
42cell adhesion mediated by integrin (GO:0033627)2.89468828
43positive regulation of glycogen metabolic process (GO:0070875)2.86112961
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.83890988
45mannose metabolic process (GO:0006013)2.83192805
46intestinal cholesterol absorption (GO:0030299)2.82633162
47positive regulation of histone deacetylation (GO:0031065)2.82218083
48regulation of nucleobase-containing compound transport (GO:0032239)2.80846593
49cerebellar Purkinje cell layer development (GO:0021680)2.77232422
50positive regulation of glycolytic process (GO:0045821)2.76050366
51protein targeting to plasma membrane (GO:0072661)2.74148311
52regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.73740690
53regulation of RNA export from nucleus (GO:0046831)2.73267465
54stress fiber assembly (GO:0043149)2.73239967
554-hydroxyproline metabolic process (GO:0019471)2.72121281
56alpha-linolenic acid metabolic process (GO:0036109)2.71746644
57regulation of extracellular matrix disassembly (GO:0010715)2.71438209
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.70558388
59response to endoplasmic reticulum stress (GO:0034976)2.70358646
60positive regulation of fatty acid beta-oxidation (GO:0032000)2.70264951
61negative regulation of erythrocyte differentiation (GO:0045647)2.68736352
62cytoplasmic mRNA processing body assembly (GO:0033962)2.65255141
63histone H3-K36 demethylation (GO:0070544)2.64618645
64response to laminar fluid shear stress (GO:0034616)2.61514034
65hypotonic response (GO:0006971)2.60863703
66glandular epithelial cell development (GO:0002068)2.60774049
67ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.59618663
68peptide hormone processing (GO:0016486)2.59515654
69embryonic process involved in female pregnancy (GO:0060136)2.58751551
70Golgi organization (GO:0007030)2.57637216
71response to unfolded protein (GO:0006986)2.57513841
72hormone catabolic process (GO:0042447)2.55979409
73endocrine pancreas development (GO:0031018)2.54678352
74atrioventricular valve morphogenesis (GO:0003181)2.53611103
75intestinal absorption (GO:0050892)2.53572290
76regulation of glucose import in response to insulin stimulus (GO:2001273)2.53154436
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.53093404
78cortical actin cytoskeleton organization (GO:0030866)2.52874701
79intra-Golgi vesicle-mediated transport (GO:0006891)2.52824782
80positive regulation of receptor recycling (GO:0001921)2.49269056
81L-alpha-amino acid transmembrane transport (GO:1902475)2.49156474
82plasma membrane repair (GO:0001778)2.48087952
83actin filament depolymerization (GO:0030042)2.47753271
84regulation of polysaccharide biosynthetic process (GO:0032885)2.47550170
85response to topologically incorrect protein (GO:0035966)2.44927081
86regulation of histone H3-K27 methylation (GO:0061085)2.44271668
87regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.43688402
88proline biosynthetic process (GO:0006561)2.43642452
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.42826377
90stress granule assembly (GO:0034063)2.42564740
91carnitine shuttle (GO:0006853)2.41736263
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41612158
93maternal placenta development (GO:0001893)2.39824521
94endoplasmic reticulum organization (GO:0007029)2.38600889
95endocytic recycling (GO:0032456)2.37918277
96insulin secretion (GO:0030073)2.36853664
97apoptotic process involved in morphogenesis (GO:0060561)2.36452465
98peptidyl-lysine dimethylation (GO:0018027)2.36335688
99histone H3-K9 demethylation (GO:0033169)2.35973394
100branching involved in mammary gland duct morphogenesis (GO:0060444)2.35454567
101endodermal cell differentiation (GO:0035987)2.35266732
102embryonic retina morphogenesis in camera-type eye (GO:0060059)2.34692891
103membrane protein ectodomain proteolysis (GO:0006509)2.34436887
104regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33449510
105positive regulation of myotube differentiation (GO:0010831)2.32329185
106protein localization to microtubule (GO:0035372)2.32174756
107regulation of glycogen biosynthetic process (GO:0005979)2.31872697
108regulation of glucan biosynthetic process (GO:0010962)2.31872697
109regulation of NFAT protein import into nucleus (GO:0051532)2.31742070
110positive regulation of fatty acid oxidation (GO:0046321)2.30885069
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28526797
112L-phenylalanine catabolic process (GO:0006559)2.28526797
113lactate metabolic process (GO:0006089)2.27235789
114cell communication by electrical coupling (GO:0010644)2.27015440
115negative regulation of TOR signaling (GO:0032007)2.26922762
116glucocorticoid receptor signaling pathway (GO:0042921)2.26549452
117sodium ion export (GO:0071436)2.26297321
118positive regulation of hormone biosynthetic process (GO:0046886)2.25808471
119regulation of fatty acid oxidation (GO:0046320)2.25065821
120fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24770166
121nuclear pore complex assembly (GO:0051292)2.24516483
122regulation of mammary gland epithelial cell proliferation (GO:0033599)2.24433853
123cortical cytoskeleton organization (GO:0030865)2.24171887
124histone lysine demethylation (GO:0070076)2.23678196
125actin filament bundle assembly (GO:0051017)2.23239214
126actin filament bundle organization (GO:0061572)2.23239214
127regulation of polysaccharide metabolic process (GO:0032881)2.22589365
128positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.22466124
129cell-cell junction maintenance (GO:0045217)2.22413989
130valine metabolic process (GO:0006573)2.22367512
131adherens junction organization (GO:0034332)2.20835339
132vascular endothelial growth factor signaling pathway (GO:0038084)2.20659442
133negative regulation of myotube differentiation (GO:0010832)2.20182002
134collagen fibril organization (GO:0030199)2.20039742
135fatty acid transmembrane transport (GO:1902001)2.19117083
136activation of protein kinase A activity (GO:0034199)2.18803073
137histone demethylation (GO:0016577)2.17187646
138regulation of clathrin-mediated endocytosis (GO:2000369)2.16597520
139dicarboxylic acid biosynthetic process (GO:0043650)2.16499511
140protein carboxylation (GO:0018214)2.16418570
141peptidyl-glutamic acid carboxylation (GO:0017187)2.16418570
142embryo implantation (GO:0007566)2.16412119
143lysine metabolic process (GO:0006553)2.15769906
144lysine catabolic process (GO:0006554)2.15769906
145apoptotic cell clearance (GO:0043277)2.15612147
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.15514226
147protein hydroxylation (GO:0018126)2.15017419
148inner ear receptor cell development (GO:0060119)2.14178114
149dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.14068485
150negative regulation of fatty acid transport (GO:2000192)2.14003996
151* regulation of ARF protein signal transduction (GO:0032012)2.13910357
152response to pheromone (GO:0019236)2.13574841
153negative regulation of lipid transport (GO:0032369)2.13025171
154growth hormone receptor signaling pathway (GO:0060396)2.12471754
155cellular response to epidermal growth factor stimulus (GO:0071364)2.11523528
156carnitine transmembrane transport (GO:1902603)2.11451649
157columnar/cuboidal epithelial cell development (GO:0002066)2.11087596
158positive regulation of extracellular matrix organization (GO:1903055)2.09904688
159syncytium formation by plasma membrane fusion (GO:0000768)2.09887582
160positive regulation of Cdc42 GTPase activity (GO:0043089)2.09487301
161negative regulation of protein localization to plasma membrane (GO:1903077)2.09412107
162positive regulation of triglyceride biosynthetic process (GO:0010867)2.08777139
163positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.08644182
1642-oxoglutarate metabolic process (GO:0006103)2.08441029
165modulation by virus of host morphology or physiology (GO:0019048)2.07910751
166positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.07661677
167intracellular estrogen receptor signaling pathway (GO:0030520)2.07606609
168peptidyl-threonine modification (GO:0018210)2.07253981
169NADH metabolic process (GO:0006734)2.06836821
170sulfur amino acid catabolic process (GO:0000098)2.05788969
171amino-acid betaine transport (GO:0015838)2.05776198
172carnitine transport (GO:0015879)2.05776198
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.05388571
174L-phenylalanine metabolic process (GO:0006558)2.05388571
175Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.04369808
176pinocytosis (GO:0006907)2.03492576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.26106205
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.99612650
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72556440
4ELK3_25401928_ChIP-Seq_HUVEC_Human2.52714190
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.44013020
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.40086383
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25237455
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.19007435
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16972279
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16732067
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13322767
12MYC_22102868_ChIP-Seq_BL_Human2.08719219
13VDR_21846776_ChIP-Seq_THP-1_Human1.97413374
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93862475
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93731940
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93462916
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92590983
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82652846
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81329897
20DROSHA_22980978_ChIP-Seq_HELA_Human1.76863081
21* FOXA2_19822575_ChIP-Seq_HepG2_Human1.72961777
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72775352
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69286729
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66238458
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63155225
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62777300
27EZH2_22144423_ChIP-Seq_EOC_Human1.62771820
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62116122
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58973570
30CLOCK_20551151_ChIP-Seq_293T_Human1.56981089
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56597716
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55924634
33KDM2B_26808549_Chip-Seq_K562_Human1.53784632
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53432681
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51736560
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48059330
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.41639858
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.39416566
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37611192
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.36409825
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.36409825
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35541505
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34832821
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.34346833
45TP53_22127205_ChIP-Seq_IMR90_Human1.34080085
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33231587
47ATF3_27146783_Chip-Seq_COLON_Human1.33104085
48TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32891394
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32260813
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32257191
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31573092
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30652645
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28846057
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28538788
55* EP300_21415370_ChIP-Seq_HL-1_Mouse1.27555343
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26868617
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26458785
58KDM2B_26808549_Chip-Seq_DND41_Human1.26443830
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24899815
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.21633834
61LXR_22292898_ChIP-Seq_THP-1_Human1.21306128
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20848421
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19622718
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19205408
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18795393
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18216274
67CREB1_26743006_Chip-Seq_LNCaP_Human1.17859677
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17834059
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17185046
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16633432
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16154863
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16154863
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15728528
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15588380
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.15585516
76ZNF263_19887448_ChIP-Seq_K562_Human1.14884808
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14614498
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13870776
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13579630
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12583015
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12522455
82P68_20966046_ChIP-Seq_HELA_Human1.12239161
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12074474
84AHR_22903824_ChIP-Seq_MCF-7_Human1.12069918
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.11965879
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.11959109
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11539640
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.11190198
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10845993
90GATA1_22025678_ChIP-Seq_K562_Human1.10816676
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.10356256
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.10106513
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.09194572
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08896571
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.07154651
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.07065514
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06665009
98AR_19668381_ChIP-Seq_PC3_Human1.05905823
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05630812
100TCF7_22412390_ChIP-Seq_EML_Mouse1.05571903
101VDR_24763502_ChIP-Seq_THP-1_Human1.05541064
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.04635505
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04633278
104* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04427904
105* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04395829
106NCOR1_26117541_ChIP-Seq_K562_Human1.03330289
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02890401
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02120110
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01555198
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01513715
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01467465
112SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01116915
113MAF_26560356_Chip-Seq_TH1_Human1.00828555
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00373738
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98732774
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98347725
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.98168113
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97135609
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96866077
120AR_21909140_ChIP-Seq_LNCAP_Human0.96678517
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.96598613
122* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96548337
123ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95697756
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95095158
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94959833
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.93912256
127* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93835801
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93818621
129GATA1_19941826_ChIP-Seq_K562_Human0.92506288
130ZNF274_21170338_ChIP-Seq_K562_Hela0.92171704
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.92046956
132* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91123613
133STAT3_23295773_ChIP-Seq_U87_Human0.89593463
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88982498
135RACK7_27058665_Chip-Seq_MCF-7_Human0.88778897
136TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88649950
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88545038
138SMC4_20622854_ChIP-Seq_HELA_Human0.88539010
139* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88406311
140KLF4_19829295_ChIP-Seq_ESCs_Human0.87999980
141BCAT_22108803_ChIP-Seq_LS180_Human0.87416696
142HNF4A_19822575_ChIP-Seq_HepG2_Human0.85150242
143REST_21632747_ChIP-Seq_MESCs_Mouse0.85109840
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84181222
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84161164
146* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84063013
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83890042
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83215452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.87791721
2MP0002139_abnormal_hepatobiliary_system3.39414896
3MP0005451_abnormal_body_composition3.33416680
4MP0003705_abnormal_hypodermis_morpholog3.27606491
5MP0002909_abnormal_adrenal_gland2.85400651
6MP0005365_abnormal_bile_salt2.83917092
7MP0003252_abnormal_bile_duct2.83548540
8MP0002877_abnormal_melanocyte_morpholog2.83089496
9MP0000013_abnormal_adipose_tissue2.71588666
10MP0003283_abnormal_digestive_organ2.69974376
11MP0005360_urolithiasis2.64689385
12MP0002837_dystrophic_cardiac_calcinosis2.55533372
13MP0003300_gastrointestinal_ulcer2.46667614
14MP0005409_darkened_coat_color2.43510279
15MP0008961_abnormal_basal_metabolism2.30211577
16MP0001944_abnormal_pancreas_morphology2.10601097
17MP0005085_abnormal_gallbladder_physiolo1.98271412
18MP0005220_abnormal_exocrine_pancreas1.90483840
19MP0000003_abnormal_adipose_tissue1.88953862
20MP0001666_abnormal_nutrient_absorption1.86829761
21MP0000733_abnormal_muscle_development1.86188342
22MP0001958_emphysema1.86079876
23MP0004043_abnormal_pH_regulation1.81112930
24MP0005058_abnormal_lysosome_morphology1.79459472
25MP0003191_abnormal_cellular_cholesterol1.77409721
26MP0008438_abnormal_cutaneous_collagen1.73808476
27MP0002693_abnormal_pancreas_physiology1.71862306
28MP0003183_abnormal_peptide_metabolism1.71228441
29MP0005076_abnormal_cell_differentiation1.70370287
30MP0005670_abnormal_white_adipose1.69478447
31MP0003045_fibrosis1.69277533
32MP0001348_abnormal_lacrimal_gland1.66663966
33MP0000569_abnormal_digit_pigmentation1.64645779
34MP0004233_abnormal_muscle_weight1.62648988
35MP0008260_abnormal_autophagy1.61739698
36MP0003868_abnormal_feces_composition1.60720262
37MP0002078_abnormal_glucose_homeostasis1.56503970
38MP0005375_adipose_tissue_phenotype1.56248071
39MP0002060_abnormal_skin_morphology1.55849212
40MP0002896_abnormal_bone_mineralization1.55648501
41MP0001299_abnormal_eye_distance/1.53553246
42MP0010329_abnormal_lipoprotein_level1.52274251
43MP0000759_abnormal_skeletal_muscle1.51330949
44MP0003453_abnormal_keratinocyte_physiol1.50497805
45MP0005023_abnormal_wound_healing1.49646137
46MP0005666_abnormal_adipose_tissue1.49136825
47MP0004264_abnormal_extraembryonic_tissu1.46067756
48MP0003195_calcinosis1.43084588
49MP0005410_abnormal_fertilization1.41625346
50MP0005083_abnormal_biliary_tract1.40971285
51MP0002234_abnormal_pharynx_morphology1.37788939
52MP0002796_impaired_skin_barrier1.34246358
53MP0004130_abnormal_muscle_cell1.33590979
54MP0004858_abnormal_nervous_system1.32578408
55MP0010234_abnormal_vibrissa_follicle1.28141602
56MP0003950_abnormal_plasma_membrane1.27784325
57MP0000678_abnormal_parathyroid_gland1.26874144
58MP0002928_abnormal_bile_duct1.25054987
59MP0000767_abnormal_smooth_muscle1.22509306
60MP0004185_abnormal_adipocyte_glucose1.22431155
61MP0003172_abnormal_lysosome_physiology1.17903360
62MP0006138_congestive_heart_failure1.17754030
63MP0002118_abnormal_lipid_homeostasis1.17165583
64MP0009840_abnormal_foam_cell1.16144616
65MP0001849_ear_inflammation1.15055058
66MP0009384_cardiac_valve_regurgitation1.13266062
67MP0002269_muscular_atrophy1.12508743
68MP0010386_abnormal_urinary_bladder1.11679923
69MP0000749_muscle_degeneration1.11677035
70MP0003122_maternal_imprinting1.11559676
71MP0010630_abnormal_cardiac_muscle1.10762032
72MP0005501_abnormal_skin_physiology1.10568913
73MP0000537_abnormal_urethra_morphology1.10216318
74MP0005187_abnormal_penis_morphology1.09269384
75MP0004270_analgesia1.06754649
76MP0002168_other_aberrant_phenotype1.06613826
77MP0004145_abnormal_muscle_electrophysio1.04837362
78MP0009672_abnormal_birth_weight1.04072381
79MP0005621_abnormal_cell_physiology1.03837920
80MP0001915_intracranial_hemorrhage0.99277114
81MP0001765_abnormal_ion_homeostasis0.98603417
82MP0002249_abnormal_larynx_morphology0.98358791
83MP0000609_abnormal_liver_physiology0.97921722
84MP0000534_abnormal_ureter_morphology0.97894766
85MP0001661_extended_life_span0.97569704
86MP0006054_spinal_hemorrhage0.97143152
87MP0004947_skin_inflammation0.96064034
88MP0005275_abnormal_skin_tensile0.95865582
89MP0002653_abnormal_ependyma_morphology0.95716779
90MP0001270_distended_abdomen0.95261075
91MP0005623_abnormal_meninges_morphology0.94767136
92MP0004510_myositis0.94357154
93MP0000750_abnormal_muscle_regeneration0.93735293
94MP0005448_abnormal_energy_balance0.93583249
95MP0005330_cardiomyopathy0.93467106
96MP0004087_abnormal_muscle_fiber0.92980843
97MP0003279_aneurysm0.92808033
98MP0002108_abnormal_muscle_morphology0.92673955
99MP0003566_abnormal_cell_adhesion0.92514070
100MP0003953_abnormal_hormone_level0.92080283
101MP0000858_altered_metastatic_potential0.90439466
102MP0003959_abnormal_lean_body0.87662778
103MP0001730_embryonic_growth_arrest0.87456629
104MP0004036_abnormal_muscle_relaxation0.85796016
105MP0001502_abnormal_circadian_rhythm0.85699723
106MP0003329_amyloid_beta_deposits0.85423028
107MP0000762_abnormal_tongue_morphology0.85230313
108MP0000467_abnormal_esophagus_morphology0.84788972
109MP0000751_myopathy0.84250938
110MP0000462_abnormal_digestive_system0.83221501
111MP0010368_abnormal_lymphatic_system0.82593090
112MP0001756_abnormal_urination0.82260815
113MP0004084_abnormal_cardiac_muscle0.81707615
114MP0010352_gastrointestinal_tract_polyps0.81705815
115MP0000428_abnormal_craniofacial_morphol0.81557396
116MP0003385_abnormal_body_wall0.80964889
117MP0009643_abnormal_urine_homeostasis0.80717433
118MP0000579_abnormal_nail_morphology0.80338460
119MP0005334_abnormal_fat_pad0.79534760
120MP0010030_abnormal_orbit_morphology0.78363078
121MP0008875_abnormal_xenobiotic_pharmacok0.77854425
122MP0003115_abnormal_respiratory_system0.77279595
123MP0004859_abnormal_synaptic_plasticity0.77252743
124MP0006072_abnormal_retinal_apoptosis0.76139636
125MP0001216_abnormal_epidermal_layer0.75939780
126MP0005535_abnormal_body_temperature0.75768930
127MP0002089_abnormal_postnatal_growth/wei0.74437510
128MP0009703_decreased_birth_body0.74036366
129MP0000747_muscle_weakness0.73782988
130MP0005503_abnormal_tendon_morphology0.73528930
131MP0005257_abnormal_intraocular_pressure0.72918671
132MP0003942_abnormal_urinary_system0.72659825
133MP0002086_abnormal_extraembryonic_tissu0.71605110
134MP0002971_abnormal_brown_adipose0.71376334
135MP0003634_abnormal_glial_cell0.70419999
136MP0003828_pulmonary_edema0.70334925
137MP0005332_abnormal_amino_acid0.69268448
138MP0005508_abnormal_skeleton_morphology0.69258098
139MP0003091_abnormal_cell_migration0.69084137
140MP0004272_abnormal_basement_membrane0.69068907
141MP0005369_muscle_phenotype0.67134023
142MP0002925_abnormal_cardiovascular_devel0.67104558
143MP0001346_abnormal_lacrimal_gland0.66030546
144MP0002106_abnormal_muscle_physiology0.65745918
145MP0003984_embryonic_growth_retardation0.65046629
146MP0001243_abnormal_dermal_layer0.64725102
147MP0001614_abnormal_blood_vessel0.64514905
148MP0003879_abnormal_hair_cell0.64024289
149MP0003941_abnormal_skin_development0.63385196
150MP0009931_abnormal_skin_appearance0.63031165
151MP0002098_abnormal_vibrissa_morphology0.62982421
152MP0000604_amyloidosis0.62554947

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)3.45770706
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38587624
3Hypoglycemic seizures (HP:0002173)3.23691290
4Hypoglycemic coma (HP:0001325)3.20765716
5Distal lower limb amyotrophy (HP:0008944)3.15239387
6Increased connective tissue (HP:0009025)3.06677885
7Insulin-resistant diabetes mellitus (HP:0000831)2.98175126
8Hyperglycemia (HP:0003074)2.96667726
9Ketoacidosis (HP:0001993)2.93339713
10Broad face (HP:0000283)2.85893511
11Macroorchidism (HP:0000053)2.82398966
12Atrophic scars (HP:0001075)2.77814416
13Cerebral aneurysm (HP:0004944)2.75809107
14Flat acetabular roof (HP:0003180)2.70710114
15Obstructive sleep apnea (HP:0002870)2.68410001
16Long toe (HP:0010511)2.66346759
17Fragile skin (HP:0001030)2.65602440
18Arterial tortuosity (HP:0005116)2.61052311
19Vascular tortuosity (HP:0004948)2.56617026
20Spinal rigidity (HP:0003306)2.55935097
21Distal lower limb muscle weakness (HP:0009053)2.54451188
22Abnormality of the intrinsic pathway (HP:0010989)2.51999833
23Aneurysm (HP:0002617)2.51861730
24Aortic dissection (HP:0002647)2.51658220
25Vertebral compression fractures (HP:0002953)2.50843431
26Deep venous thrombosis (HP:0002625)2.48946268
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.45377328
28Abnormality of skeletal muscle fiber size (HP:0012084)2.45153007
29Hand muscle atrophy (HP:0009130)2.45135953
30Neoplasm of the heart (HP:0100544)2.42994678
31Symptomatic seizures (HP:0011145)2.42563524
32Ulnar bowing (HP:0003031)2.42241451
33Wormian bones (HP:0002645)2.41628765
34Abnormality of endocrine pancreas physiology (HP:0012093)2.40435687
35Abnormality of the pancreatic islet cells (HP:0006476)2.40435687
36Lower limb amyotrophy (HP:0007210)2.37529187
37Protrusio acetabuli (HP:0003179)2.36456209
38Exercise-induced myalgia (HP:0003738)2.36031175
39Ketosis (HP:0001946)2.34324164
40Disproportionate tall stature (HP:0001519)2.31302595
41Distal upper limb amyotrophy (HP:0007149)2.28747875
42Upper limb amyotrophy (HP:0009129)2.28747875
43Mildly elevated creatine phosphokinase (HP:0008180)2.24981680
44Lymphangioma (HP:0100764)2.20379111
45Osteolytic defects of the hand bones (HP:0009699)2.19729251
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.19729251
47Achilles tendon contracture (HP:0001771)2.17042457
48Renovascular hypertension (HP:0100817)2.16560253
49Hyperacusis (HP:0010780)2.15965067
50Mitral regurgitation (HP:0001653)2.15477049
51Skin nodule (HP:0200036)2.15460845
52Enlarged penis (HP:0000040)2.15347561
53Dilatation of the ascending aorta (HP:0005111)2.14731874
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.13226558
55Mucopolysacchariduria (HP:0008155)2.12930694
56Urinary glycosaminoglycan excretion (HP:0003541)2.12930694
57Abnormality of the common coagulation pathway (HP:0010990)2.12380563
58Turricephaly (HP:0000262)2.11989709
59Intrahepatic cholestasis (HP:0001406)2.10316221
60Blue sclerae (HP:0000592)2.07084532
61Myopathic facies (HP:0002058)2.03002794
62Abnormality of the Achilles tendon (HP:0005109)2.02436260
63Agitation (HP:0000713)2.02091846
64Abnormality of polysaccharide metabolism (HP:0011012)2.02001227
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02001227
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02001227
67Short nail (HP:0001799)2.01845555
68Retinal atrophy (HP:0001105)2.01432642
69Abnormality of dentin (HP:0010299)2.01280572
70Abnormality of the ischium (HP:0003174)2.00737505
71Asymmetric septal hypertrophy (HP:0001670)2.00341173
72Abnormality of the lower motor neuron (HP:0002366)1.99824593
73Hypoplastic ischia (HP:0003175)1.99425246
74Advanced eruption of teeth (HP:0006288)1.96768182
75Hyporeflexia of lower limbs (HP:0002600)1.95873032
76Genu recurvatum (HP:0002816)1.95179879
77Bowel diverticulosis (HP:0005222)1.94496937
78Global brain atrophy (HP:0002283)1.94410849
79Long palpebral fissure (HP:0000637)1.93984830
80Difficulty climbing stairs (HP:0003551)1.93288620
81Pancreatic islet-cell hyperplasia (HP:0004510)1.92879186
82Insulin resistance (HP:0000855)1.92433957
83Thin bony cortex (HP:0002753)1.91454251
84Late onset (HP:0003584)1.89341918
85Aortic aneurysm (HP:0004942)1.89298112
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.87308521
87Shallow orbits (HP:0000586)1.86187142
88Hypercortisolism (HP:0001578)1.85509054
89Elfin facies (HP:0004428)1.85114444
90Bundle branch block (HP:0011710)1.83470309
91Bladder diverticulum (HP:0000015)1.82468855
92Ankyloglossia (HP:0010296)1.81531423
93Abnormal ossification of hand bones (HP:0005921)1.81275722
94Abnormality of calcium-phosphate metabolism (HP:0100530)1.81222904
95Protuberant abdomen (HP:0001538)1.81088057
96Joint laxity (HP:0001388)1.81005263
97Neonatal short-limb short stature (HP:0008921)1.79940602
98Dislocated radial head (HP:0003083)1.79723605
99Hyperextensible skin (HP:0000974)1.79220431
100Abnormality of the distal phalanges of the toes (HP:0010182)1.79028932
101Cerebral inclusion bodies (HP:0100314)1.78720008
102Overgrowth (HP:0001548)1.78510702
103Elbow flexion contracture (HP:0002987)1.77413089
104Ulnar deviation of the wrist (HP:0003049)1.76883534
105Round ear (HP:0100830)1.76878084
106Xanthomatosis (HP:0000991)1.76671170
107Papillary thyroid carcinoma (HP:0002895)1.76669462
108Sparse lateral eyebrow (HP:0005338)1.76085454
109Epidermoid cyst (HP:0200040)1.75282088
110Hypoalphalipoproteinemia (HP:0003233)1.75145093
111Biconcave vertebral bodies (HP:0004586)1.74655486
112Mitral valve prolapse (HP:0001634)1.74538887
113Abnormality of the acetabulum (HP:0003170)1.74245908
114Central scotoma (HP:0000603)1.74216870
115Dysmetric saccades (HP:0000641)1.73225759
116Hemorrhage of the eye (HP:0011885)1.73188137
117Male infertility (HP:0003251)1.72749166
118Mitral stenosis (HP:0001718)1.72477483
119Premature rupture of membranes (HP:0001788)1.71636347
120Abnormality of the calcaneus (HP:0008364)1.71616242
121Abnormality of carpal bone ossification (HP:0006257)1.71254960
122Spondylolisthesis (HP:0003302)1.69810042
123Hypoplastic labia majora (HP:0000059)1.68999521
124Back pain (HP:0003418)1.68808522
125Natal tooth (HP:0000695)1.68193436
126Exostoses (HP:0100777)1.67242112
127Dysostosis multiplex (HP:0000943)1.66776051
128Long eyelashes (HP:0000527)1.66474213
129Hamartoma of the eye (HP:0010568)1.66178170
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65686974
131Insomnia (HP:0100785)1.65182660
132Premature skin wrinkling (HP:0100678)1.64648968
133Abnormality of oral frenula (HP:0000190)1.64452765
134Asymmetry of the thorax (HP:0001555)1.64265279
135Right ventricular cardiomyopathy (HP:0011663)1.64242544
136Large for gestational age (HP:0001520)1.64155633
137Type 1 muscle fiber predominance (HP:0003803)1.63437229
138Abnormal pancreas size (HP:0012094)1.63218168
139Thin ribs (HP:0000883)1.63174278
140Abnormality of the radial head (HP:0003995)1.63069937
141Ankle contracture (HP:0006466)1.62695376
142Hammertoe (HP:0001765)1.61457230
143Abnormality of the labia majora (HP:0012881)1.59987085
144Buphthalmos (HP:0000557)1.59899364
145Hyperkalemia (HP:0002153)1.59854085
146Gout (HP:0001997)1.59357286
147Congenital glaucoma (HP:0001087)1.59280666
148Hypsarrhythmia (HP:0002521)1.59179157
149Persistence of primary teeth (HP:0006335)1.59044944
150Scapular winging (HP:0003691)1.58735851
151Vertebral arch anomaly (HP:0008438)1.57400320
152Hepatoblastoma (HP:0002884)1.57279685
153Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.56948770
154Subacute progressive viral hepatitis (HP:0006572)1.56883860
155Cervical subluxation (HP:0003308)1.56782934
156EEG with generalized epileptiform discharges (HP:0011198)1.56600542
157Peritonitis (HP:0002586)1.56501966
158Difficulty running (HP:0009046)1.56061487
159Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.55692913
160Soft skin (HP:0000977)1.55672431
161Increased variability in muscle fiber diameter (HP:0003557)1.54154353
162Cubitus valgus (HP:0002967)1.53838143
163Coxa vara (HP:0002812)1.53321150
164Ventricular tachycardia (HP:0004756)1.52578086
165Termporal pattern (HP:0011008)1.51749967
166Abnormality of the fingertips (HP:0001211)1.51258208
167Menstrual irregularities (HP:0000858)1.49719461
168Complement deficiency (HP:0004431)1.49302068
169Striae distensae (HP:0001065)1.49114982
170Broad metatarsal (HP:0001783)1.47928191
171Heterotopia (HP:0002282)1.47270728
172Increased CSF protein (HP:0002922)1.47245095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.75643025
2INSRR3.49780226
3PRKD33.11315230
4ERN12.94518235
5SMG12.91634517
6PRPF4B2.71010215
7SIK12.43808038
8PKN22.40611462
9LATS12.22517703
10EPHA22.18299287
11TAOK31.98062993
12EEF2K1.94752978
13PTK61.89467888
14MST1R1.87893857
15CAMK1G1.84116254
16PDGFRA1.80917704
17FRK1.74556025
18MAPK151.73768035
19CDK121.73723230
20RIPK11.72933270
21ICK1.64873327
22IRAK31.64199938
23WNK41.60760867
24SCYL21.59841860
25MAP3K101.55911582
26CAMK1D1.55807305
27PDK41.55514462
28PDK31.55514462
29RET1.46151860
30MAP3K21.45212599
31LMTK21.45020762
32AKT31.37034027
33TTN1.36507766
34EPHA31.30522733
35PRKCH1.28455365
36MTOR1.27270744
37CDC42BPA1.24869408
38WNK11.21022103
39FGFR41.19045496
40HIPK21.14907519
41NEK91.14502836
42NTRK11.13294724
43TESK11.12449924
44PAK61.12413487
45PASK1.11529622
46STK381.11353637
47WNK31.07487535
48MAP2K31.07322198
49PTK21.06594355
50PAK31.05365279
51SGK31.00763104
52MAP3K70.99865004
53DMPK0.99636249
54BCKDK0.99044048
55KSR20.97909294
56JAK10.97132739
57MAP3K130.95167983
58PAK40.94421187
59LATS20.90822255
60TAOK10.88541181
61CAMKK10.87237607
62DYRK1B0.86655868
63DDR20.86198451
64FER0.84942815
65SIK20.82904881
66* PRKAA10.82817830
67RPS6KA20.82565017
68EPHB10.81946637
69MAP3K10.80724867
70PDGFRB0.80286404
71ARAF0.80143578
72MAP3K60.77590987
73MARK20.75383153
74TRPM70.75336177
75NTRK30.74750802
76FGFR30.74123646
77MAP3K40.73451223
78MAPK110.71140229
79MOS0.69314005
80MAP3K30.69210045
81TAOK20.67481117
82SIK30.66126316
83PDK20.63816680
84TESK20.62840706
85PAK20.61964253
86JAK20.60297075
87PRKD20.59715486
88PHKG10.58431516
89PHKG20.58431516
90ERBB20.58205366
91BRD40.57576759
92BMX0.57215838
93CDK90.56166722
94PRKD10.55335301
95PDK10.54910042
96SGK20.54741891
97MELK0.53047367
98EPHB20.52751367
99PRKAA20.50936157
100MAP3K80.50603422
101PDPK10.50464914
102FGFR20.49738019
103MAPK120.48574315
104MAP2K40.48256241
105ALK0.47427871
106FLT30.47010284
107MAP3K90.46923432
108MET0.46034367
109ROCK10.45757618
110PRKG20.45646510
111LRRK20.45257532
112MAPKAPK30.45008765
113RPS6KB10.44839803
114TYRO30.44214471
115PTK2B0.44188766
116STK30.42341138
117MYLK0.41214490
118CDK70.40714932
119ZAP700.40101073
120GSK3A0.39284043
121MAPK100.39259513
122RPS6KC10.38530475
123RPS6KL10.38530475
124BRAF0.38455516
125SGK4940.38156847
126SGK2230.38156847
127CDK50.37947273
128FGFR10.37591244
129CDK60.36295868
130RPS6KA30.36030372
131MAP3K140.35491115
132PIK3CG0.35490266
133KSR10.34724216
134MAP2K10.34723333
135AKT20.34513189
136LIMK10.34106651
137ROCK20.34035304
138TYK20.32418210
139RAF10.32058433

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.44538388
2Nitrogen metabolism_Homo sapiens_hsa009102.08864893
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98389480
4Insulin secretion_Homo sapiens_hsa049111.92115016
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84457192
6Type II diabetes mellitus_Homo sapiens_hsa049301.83461634
7Other glycan degradation_Homo sapiens_hsa005111.65841049
8Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58256154
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50698062
10Notch signaling pathway_Homo sapiens_hsa043301.50122689
11Lysine degradation_Homo sapiens_hsa003101.49433674
12Acute myeloid leukemia_Homo sapiens_hsa052211.47736579
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47183068
14Pancreatic cancer_Homo sapiens_hsa052121.46708545
15Insulin resistance_Homo sapiens_hsa049311.44699938
16Thyroid cancer_Homo sapiens_hsa052161.43894327
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43132424
18VEGF signaling pathway_Homo sapiens_hsa043701.42013915
19Glucagon signaling pathway_Homo sapiens_hsa049221.41736488
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.35585322
21Small cell lung cancer_Homo sapiens_hsa052221.34904638
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34161980
23Renal cell carcinoma_Homo sapiens_hsa052111.33621868
24Sulfur metabolism_Homo sapiens_hsa009201.32421952
25Selenocompound metabolism_Homo sapiens_hsa004501.30228973
26Bile secretion_Homo sapiens_hsa049761.29222026
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29079763
28Tryptophan metabolism_Homo sapiens_hsa003801.28785281
29ErbB signaling pathway_Homo sapiens_hsa040121.25565912
30Arginine biosynthesis_Homo sapiens_hsa002201.23031163
31Fatty acid degradation_Homo sapiens_hsa000711.22953200
32ABC transporters_Homo sapiens_hsa020101.21451326
33mTOR signaling pathway_Homo sapiens_hsa041501.18962651
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14797479
35Fat digestion and absorption_Homo sapiens_hsa049751.13896507
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13379472
37PPAR signaling pathway_Homo sapiens_hsa033201.10316852
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09594590
39Fructose and mannose metabolism_Homo sapiens_hsa000511.06165451
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05511993
41Cocaine addiction_Homo sapiens_hsa050301.05192332
42Insulin signaling pathway_Homo sapiens_hsa049101.04640910
43Starch and sucrose metabolism_Homo sapiens_hsa005001.03549567
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03237455
45Dorso-ventral axis formation_Homo sapiens_hsa043201.02850606
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02784865
47Fatty acid metabolism_Homo sapiens_hsa012121.02352352
48MicroRNAs in cancer_Homo sapiens_hsa052061.02219632
49Propanoate metabolism_Homo sapiens_hsa006401.02046801
50AMPK signaling pathway_Homo sapiens_hsa041521.01968610
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.99976653
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99685564
53Estrogen signaling pathway_Homo sapiens_hsa049150.99441510
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99238553
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.99223496
56Protein digestion and absorption_Homo sapiens_hsa049740.98391172
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98242463
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96928717
59Choline metabolism in cancer_Homo sapiens_hsa052310.96197517
60Butanoate metabolism_Homo sapiens_hsa006500.96143028
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96116037
62Thyroid hormone synthesis_Homo sapiens_hsa049180.94583974
63Circadian rhythm_Homo sapiens_hsa047100.91080505
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90928660
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89339638
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.89043457
67Pentose phosphate pathway_Homo sapiens_hsa000300.88800852
68N-Glycan biosynthesis_Homo sapiens_hsa005100.87117139
69Vibrio cholerae infection_Homo sapiens_hsa051100.86576831
70Endometrial cancer_Homo sapiens_hsa052130.85918125
71Pancreatic secretion_Homo sapiens_hsa049720.85575703
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84784040
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82206839
74Amphetamine addiction_Homo sapiens_hsa050310.81957997
75B cell receptor signaling pathway_Homo sapiens_hsa046620.81863572
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81503480
77Fatty acid biosynthesis_Homo sapiens_hsa000610.81491195
78Colorectal cancer_Homo sapiens_hsa052100.79186634
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.78997857
80Hepatitis C_Homo sapiens_hsa051600.77935132
81Melanogenesis_Homo sapiens_hsa049160.77696457
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77275658
83* Endocytosis_Homo sapiens_hsa041440.76673520
84Renin secretion_Homo sapiens_hsa049240.75994241
85Dilated cardiomyopathy_Homo sapiens_hsa054140.74965652
86Hepatitis B_Homo sapiens_hsa051610.74735216
87Glioma_Homo sapiens_hsa052140.73874888
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73416928
89Focal adhesion_Homo sapiens_hsa045100.73334955
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.72948187
91Synaptic vesicle cycle_Homo sapiens_hsa047210.72143107
92Tight junction_Homo sapiens_hsa045300.71519894
93Long-term potentiation_Homo sapiens_hsa047200.70510167
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70449703
95Glycerolipid metabolism_Homo sapiens_hsa005610.69769736
96Dopaminergic synapse_Homo sapiens_hsa047280.69674080
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69585155
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69336397
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.67511041
100Pyruvate metabolism_Homo sapiens_hsa006200.67339661
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66951840
102Circadian entrainment_Homo sapiens_hsa047130.66885633
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66871428
104FoxO signaling pathway_Homo sapiens_hsa040680.66649410
105Cholinergic synapse_Homo sapiens_hsa047250.66050851
106Biosynthesis of amino acids_Homo sapiens_hsa012300.64916391
107Prolactin signaling pathway_Homo sapiens_hsa049170.63537287
108Axon guidance_Homo sapiens_hsa043600.63492525
109Apoptosis_Homo sapiens_hsa042100.63127684
110HIF-1 signaling pathway_Homo sapiens_hsa040660.63088450
111Adherens junction_Homo sapiens_hsa045200.62737764
112Toxoplasmosis_Homo sapiens_hsa051450.62006922
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.61641226
114Pathways in cancer_Homo sapiens_hsa052000.60886179
115TNF signaling pathway_Homo sapiens_hsa046680.60869566
116Chronic myeloid leukemia_Homo sapiens_hsa052200.60332656
117Prion diseases_Homo sapiens_hsa050200.60300060
118Galactose metabolism_Homo sapiens_hsa000520.59666532
119Gastric acid secretion_Homo sapiens_hsa049710.59531210
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59227958
121Platelet activation_Homo sapiens_hsa046110.59167173
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57914290
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57815270
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.57688530
125Viral carcinogenesis_Homo sapiens_hsa052030.56952122
126Shigellosis_Homo sapiens_hsa051310.55739011
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55702616
128Rap1 signaling pathway_Homo sapiens_hsa040150.55187061
129Complement and coagulation cascades_Homo sapiens_hsa046100.54999063
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54200111
131Amoebiasis_Homo sapiens_hsa051460.54143422
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.53082719
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52637504
134Proteoglycans in cancer_Homo sapiens_hsa052050.52011650
135GnRH signaling pathway_Homo sapiens_hsa049120.51801145
136Non-small cell lung cancer_Homo sapiens_hsa052230.51487988
137cAMP signaling pathway_Homo sapiens_hsa040240.50737033
138ECM-receptor interaction_Homo sapiens_hsa045120.48661311
139Inositol phosphate metabolism_Homo sapiens_hsa005620.48410007
140Prostate cancer_Homo sapiens_hsa052150.47182649
141Gap junction_Homo sapiens_hsa045400.46166402
142Salivary secretion_Homo sapiens_hsa049700.44394743
143GABAergic synapse_Homo sapiens_hsa047270.44221382
144Bladder cancer_Homo sapiens_hsa052190.43870959
145Lysosome_Homo sapiens_hsa041420.43602775
146Carbon metabolism_Homo sapiens_hsa012000.43171196
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41471707

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