ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.65953166
2	sulfation (GO:0051923)	6.64213110
3	cellular response to ATP (GO:0071318)	5.92351574
4	regulation of glomerulus development (GO:0090192)	5.52803700
5	water-soluble vitamin biosynthetic process (GO:0042364)	5.17020840
6	cell proliferation in forebrain (GO:0021846)	5.09217529
7	regulation of cell proliferation involved in kidney development (GO:1901722)	4.57187383
8	gamma-aminobutyric acid transport (GO:0015812)	4.52594590
9	kynurenine metabolic process (GO:0070189)	4.28556017
10	DNA deamination (GO:0045006)	4.25239981
11	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	4.24539212
12	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	4.24539212
13	negative regulation of systemic arterial blood pressure (GO:0003085)	4.22968591
14	indole-containing compound catabolic process (GO:0042436)	4.18799808
15	indolalkylamine catabolic process (GO:0046218)	4.18799808
16	tryptophan catabolic process (GO:0006569)	4.18799808
17	cellular anion homeostasis (GO:0030002)	4.10592318
18	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.04729936
19	positive regulation of fatty acid beta-oxidation (GO:0032000)	4.00271569
20	regulation of phospholipid biosynthetic process (GO:0071071)	3.95193818
21	positive regulation of fatty acid oxidation (GO:0046321)	3.91964752
22	positive regulation of cAMP-mediated signaling (GO:0043950)	3.90761472
23	negative regulation of appetite (GO:0032099)	3.81252244
24	negative regulation of response to food (GO:0032096)	3.81252244
25	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.63457421
26	flavonoid metabolic process (GO:0009812)	3.59848724
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54154889
28	NADH dehydrogenase complex assembly (GO:0010257)	3.54154889
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54154889
30	indolalkylamine metabolic process (GO:0006586)	3.52251544
31	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.49780901
32	positive regulation of metanephros development (GO:0072216)	3.49380723
33	tryptophan metabolic process (GO:0006568)	3.45200306
34	regulation of gene silencing by RNA (GO:0060966)	3.44776443
35	regulation of posttranscriptional gene silencing (GO:0060147)	3.44776443
36	regulation of gene silencing by miRNA (GO:0060964)	3.44776443
37	cellular response to exogenous dsRNA (GO:0071360)	3.43587517
38	somite development (GO:0061053)	3.42488675
39	regulation of sequestering of triglyceride (GO:0010889)	3.41809584
40	opsonization (GO:0008228)	3.38692890
41	protein polyglutamylation (GO:0018095)	3.27504651
42	pharyngeal system development (GO:0060037)	3.26918866
43	protein complex biogenesis (GO:0070271)	3.19380263
44	indole-containing compound metabolic process (GO:0042430)	3.16745343
45	response to UV-C (GO:0010225)	3.14093403
46	tooth mineralization (GO:0034505)	3.08545486
47	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.05711271
48	otic vesicle formation (GO:0030916)	3.05381722
49	regulation of DNA endoreduplication (GO:0032875)	3.05232448
50	regulation of germinal center formation (GO:0002634)	3.01137977
51	negative regulation by host of viral transcription (GO:0043922)	2.99911757
52	regulation of mesoderm development (GO:2000380)	2.99807157
53	serotonin metabolic process (GO:0042428)	2.99007206
54	transmission of nerve impulse (GO:0019226)	2.95819665
55	positive regulation of glomerulus development (GO:0090193)	2.95291888
56	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.90402692
57	dentate gyrus development (GO:0021542)	2.89328311
58	regulation of female receptivity (GO:0045924)	2.88010717
59	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.87539531
60	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.85884642
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.84811931
62	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.84239956
63	endoderm formation (GO:0001706)	2.83224811
64	negative regulation of hormone biosynthetic process (GO:0032353)	2.82968524
65	negative regulation of mast cell activation (GO:0033004)	2.82645522
66	peristalsis (GO:0030432)	2.82223153
67	negative regulation of telomere maintenance (GO:0032205)	2.81805772
68	primary amino compound metabolic process (GO:1901160)	2.80670799
69	GPI anchor metabolic process (GO:0006505)	2.77014019
70	pituitary gland development (GO:0021983)	2.76816257
71	neuronal action potential (GO:0019228)	2.73663174
72	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.71031761
73	lung morphogenesis (GO:0060425)	2.70898069
74	parturition (GO:0007567)	2.69737671
75	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.67475976
76	N-acetylglucosamine metabolic process (GO:0006044)	2.66233985
77	regulation of hippo signaling (GO:0035330)	2.65444567
78	regulation of collateral sprouting (GO:0048670)	2.64349848
79	positive regulation of fatty acid transport (GO:2000193)	2.64081521
80	spinal cord motor neuron differentiation (GO:0021522)	2.63631952
81	membrane depolarization during action potential (GO:0086010)	2.63625608
82	musculoskeletal movement (GO:0050881)	2.62604542
83	multicellular organismal movement (GO:0050879)	2.62604542
84	negative regulation of astrocyte differentiation (GO:0048712)	2.60667412
85	negative regulation of platelet activation (GO:0010544)	2.58700720
86	cellular biogenic amine catabolic process (GO:0042402)	2.58587046
87	amine catabolic process (GO:0009310)	2.58587046
88	regulation of transcription regulatory region DNA binding (GO:2000677)	2.58279776
89	reflex (GO:0060004)	2.57888256
90	positive regulation of defense response to virus by host (GO:0002230)	2.56544448
91	regulation of neurotransmitter uptake (GO:0051580)	2.56464330
92	vitamin biosynthetic process (GO:0009110)	2.55454495
93	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.54669305
94	lateral sprouting from an epithelium (GO:0060601)	2.53371236
95	membrane repolarization during action potential (GO:0086011)	2.53038480
96	regulation of metanephros development (GO:0072215)	2.52510472
97	prostate gland growth (GO:0060736)	2.51745574
98	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.50178185
99	negative regulation of blood pressure (GO:0045776)	2.50151292
100	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.49980021

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.73717397
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.04999877
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.90775155
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.65265471
5	VDR_22108803_ChIP-Seq_LS180_Human	2.45630782
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.45241965
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38468642
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36717003
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.35213578
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.32827082
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27194243
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12865788
13	EWS_26573619_Chip-Seq_HEK293_Human	2.03879129
14	FUS_26573619_Chip-Seq_HEK293_Human	1.98695073
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.95558980
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.95013974
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.85167102
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81201632
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.78587030
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75466922
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.73998207
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71979903
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71814590
24	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.71284374
25	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.68750988
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67763903
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.67401186
28	P300_19829295_ChIP-Seq_ESCs_Human	1.64852094
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61955984
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.60578981
31	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.58793411
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.58295421
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56557262
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55346212
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.53199543
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48661565
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.47960752
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47461746
39	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.44558474
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.43543752
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43411514
42	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.42986848
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.42808198
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42808198
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42080138
46	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.40669706
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.37618303
48	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.37428277
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36761509
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35858216
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35384516
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.34523154
53	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.30205985
54	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29041428
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28847502
56	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.28245138
57	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27787285
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27702266
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27121439
60	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.25051923
61	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.23536365
62	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.23536365
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21390978
64	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.21002005
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19218852
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.17259949
67	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.17252405
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16019805
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16019805
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15867201
71	STAT3_23295773_ChIP-Seq_U87_Human	1.14610227
72	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.14187836
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13949509
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13134397
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13069830
76	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11507694
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11166040
78	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.10667421
79	TCF4_23295773_ChIP-Seq_U87_Human	1.10447388
80	NCOR_22424771_ChIP-Seq_293T_Human	1.10176764
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09499895
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09499895
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09405039
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07116107
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06650758
86	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.06529842
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.05729100
88	AR_25329375_ChIP-Seq_VCAP_Human	1.05402224
89	KDM2B_26808549_Chip-Seq_REH_Human	1.01623928
90	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00976199
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.00776927
92	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.00610977
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.00582633
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00262252
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00012106
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99859408
97	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.99770665
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99055174
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.97528743
100	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.97457337

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.21559433
2	MP0006292_abnormal_olfactory_placode	3.19400551
3	MP0004145_abnormal_muscle_electrophysio	3.15414812
4	MP0003195_calcinosis	2.85265256
5	MP0001485_abnormal_pinna_reflex	2.75363471
6	MP0004885_abnormal_endolymph	2.68554077
7	MP0004134_abnormal_chest_morphology	2.62592436
8	MP0003646_muscle_fatigue	2.57864272
9	MP0002160_abnormal_reproductive_system	2.42156557
10	MP0002138_abnormal_hepatobiliary_system	2.32382750
11	MP0002876_abnormal_thyroid_physiology	2.29326186
12	MP0000631_abnormal_neuroendocrine_gland	2.17200250
13	MP0000049_abnormal_middle_ear	2.16327173
14	MP0001968_abnormal_touch/_nociception	2.16325289
15	MP0008872_abnormal_physiological_respon	2.13479416
16	MP0004130_abnormal_muscle_cell	2.08092654
17	MP0008877_abnormal_DNA_methylation	2.00930878
18	MP0002102_abnormal_ear_morphology	1.93532192
19	MP0002837_dystrophic_cardiac_calcinosis	1.92496328
20	MP0002163_abnormal_gland_morphology	1.91573811
21	MP0005389_reproductive_system_phenotype	1.91248346
22	MP0002272_abnormal_nervous_system	1.89039733
23	MP0005551_abnormal_eye_electrophysiolog	1.82800725
24	MP0004142_abnormal_muscle_tone	1.82176641
25	MP0009250_abnormal_appendicular_skeleto	1.75617981
26	MP0009745_abnormal_behavioral_response	1.71992002
27	MP0002735_abnormal_chemical_nociception	1.70535963
28	MP0009379_abnormal_foot_pigmentation	1.69195284
29	MP0001440_abnormal_grooming_behavior	1.58313652
30	MP0002733_abnormal_thermal_nociception	1.54024683
31	MP0009046_muscle_twitch	1.54003302
32	MP0004133_heterotaxia	1.53189965
33	MP0003011_delayed_dark_adaptation	1.52723953
34	MP0006072_abnormal_retinal_apoptosis	1.52464642
35	MP0002734_abnormal_mechanical_nocicepti	1.48650429
36	MP0002277_abnormal_respiratory_mucosa	1.47651841
37	MP0003724_increased_susceptibility_to	1.47436963
38	MP0003638_abnormal_response/metabolism_	1.46836115
39	MP0002736_abnormal_nociception_after	1.46588162
40	MP0005671_abnormal_response_to	1.42556217
41	MP0003879_abnormal_hair_cell	1.40482947
42	MP0002064_seizures	1.31142743
43	MP0000678_abnormal_parathyroid_gland	1.30487088
44	MP0001970_abnormal_pain_threshold	1.30057598
45	MP0000613_abnormal_salivary_gland	1.26360285
46	MP0003938_abnormal_ear_development	1.24208889
47	MP0003283_abnormal_digestive_organ	1.22863006
48	MP0005379_endocrine/exocrine_gland_phen	1.22599928
49	MP0002089_abnormal_postnatal_growth/wei	1.22021667
50	MP0005084_abnormal_gallbladder_morpholo	1.18919191
51	MP0009053_abnormal_anal_canal	1.15629348
52	MP0003119_abnormal_digestive_system	1.14616322
53	MP0002653_abnormal_ependyma_morphology	1.12636020
54	MP0001919_abnormal_reproductive_system	1.12358062
55	MP0001986_abnormal_taste_sensitivity	1.10562578
56	MP0001963_abnormal_hearing_physiology	1.09477171
57	MP0000026_abnormal_inner_ear	1.09353518
58	MP0001486_abnormal_startle_reflex	1.08820984
59	MP0004742_abnormal_vestibular_system	1.05059707
60	MP0001905_abnormal_dopamine_level	1.04377340
61	MP0009780_abnormal_chondrocyte_physiolo	1.03735418
62	MP0004215_abnormal_myocardial_fiber	1.01930543
63	MP0005670_abnormal_white_adipose	0.99354400
64	MP0003937_abnormal_limbs/digits/tail_de	0.97843087
65	MP0002638_abnormal_pupillary_reflex	0.96558411
66	MP0000230_abnormal_systemic_arterial	0.91366424
67	MP0009765_abnormal_xenobiotic_induced	0.90261962
68	MP0005174_abnormal_tail_pigmentation	0.90185611
69	MP0002282_abnormal_trachea_morphology	0.89401041
70	MP0005253_abnormal_eye_physiology	0.87233662
71	MP0002928_abnormal_bile_duct	0.87093802
72	MP0002148_abnormal_hypersensitivity_rea	0.86362680
73	MP0003787_abnormal_imprinting	0.86277839
74	MP0009384_cardiac_valve_regurgitation	0.86056167
75	MP0005360_urolithiasis	0.85571048
76	MP0001177_atelectasis	0.84435294
77	MP0002572_abnormal_emotion/affect_behav	0.82031120
78	MP0005195_abnormal_posterior_eye	0.81695248
79	MP0001765_abnormal_ion_homeostasis	0.81564648
80	MP0009764_decreased_sensitivity_to	0.80467959
81	MP0005448_abnormal_energy_balance	0.79820670
82	MP0002557_abnormal_social/conspecific_i	0.78205592
83	MP0002752_abnormal_somatic_nervous	0.77757913
84	MP0003635_abnormal_synaptic_transmissio	0.77623292
85	MP0002249_abnormal_larynx_morphology	0.77121668
86	MP0001542_abnormal_bone_strength	0.76566216
87	MP0002063_abnormal_learning/memory/cond	0.76115417
88	MP0001853_heart_inflammation	0.75884344
89	MP0002938_white_spotting	0.75033044
90	MP0003567_abnormal_fetal_cardiomyocyte	0.74278692
91	MP0002751_abnormal_autonomic_nervous	0.73023266
92	MP0002139_abnormal_hepatobiliary_system	0.70194071
93	MP0001188_hyperpigmentation	0.69413835
94	MP0002184_abnormal_innervation	0.69186828
95	MP0000569_abnormal_digit_pigmentation	0.69186795
96	MP0009785_altered_susceptibility_to	0.68858521
97	MP0002067_abnormal_sensory_capabilities	0.67073687
98	MP0004270_analgesia	0.66290365
99	MP0005332_abnormal_amino_acid	0.65541407
100	MP0008875_abnormal_xenobiotic_pharmacok	0.65207824

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.65534220
2	Pendular nystagmus (HP:0012043)	4.17976555
3	Pancreatic cysts (HP:0001737)	3.76534074
4	Abolished electroretinogram (ERG) (HP:0000550)	3.68129136
5	Progressive cerebellar ataxia (HP:0002073)	3.65324970
6	Pancreatic fibrosis (HP:0100732)	3.62923865
7	Agitation (HP:0000713)	3.48028555
8	True hermaphroditism (HP:0010459)	3.41572516
9	Methylmalonic acidemia (HP:0002912)	3.37913109
10	Congenital, generalized hypertrichosis (HP:0004540)	3.34779865
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.23012919
12	Confusion (HP:0001289)	3.17969152
13	Porencephaly (HP:0002132)	3.14863021
14	Visual hallucinations (HP:0002367)	3.09780082
15	Asplenia (HP:0001746)	3.04733833
16	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.01439708
17	Short 1st metacarpal (HP:0010034)	3.01439708
18	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.99454885
19	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.95368549
20	3-Methylglutaconic aciduria (HP:0003535)	2.92532335
21	Nephronophthisis (HP:0000090)	2.91135165
22	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.87022954
23	Congenital sensorineural hearing impairment (HP:0008527)	2.84399361
24	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.83828550
25	Methylmalonic aciduria (HP:0012120)	2.83236069
26	Hemiplegia (HP:0002301)	2.80909338
27	Keratoconus (HP:0000563)	2.80879401
28	Increased corneal curvature (HP:0100692)	2.80879401
29	Congenital stationary night blindness (HP:0007642)	2.78768889
30	Conjunctival hamartoma (HP:0100780)	2.77179852
31	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.75126765
32	Short hallux (HP:0010109)	2.70142084
33	Decreased central vision (HP:0007663)	2.69971121
34	Abnormality of the middle phalanges of the toes (HP:0010183)	2.65845092
35	Furrowed tongue (HP:0000221)	2.65423794
36	Abnormality of the 1st metacarpal (HP:0010009)	2.63528234
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.62348775
38	Molar tooth sign on MRI (HP:0002419)	2.57634029
39	Abnormality of midbrain morphology (HP:0002418)	2.57634029
40	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.55820941
41	Abnormality of binocular vision (HP:0011514)	2.55501332
42	Diplopia (HP:0000651)	2.55501332
43	Abnormality of the nasal septum (HP:0000419)	2.54970630
44	Morphological abnormality of the middle ear (HP:0008609)	2.40205773
45	Septo-optic dysplasia (HP:0100842)	2.37149579
46	Short femoral neck (HP:0100864)	2.35448453
47	Severe visual impairment (HP:0001141)	2.34964458
48	Cystic liver disease (HP:0006706)	2.32150284
49	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.30102518
50	Abnormality of the renal medulla (HP:0100957)	2.29769871
51	Carpal bone hypoplasia (HP:0001498)	2.29739326
52	Gaze-evoked nystagmus (HP:0000640)	2.28450685
53	Abnormality of the renal cortex (HP:0011035)	2.26010685
54	Chorioretinal atrophy (HP:0000533)	2.20324311
55	Sclerocornea (HP:0000647)	2.20057081
56	Renal cortical cysts (HP:0000803)	2.19428176
57	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.17987402
58	Bone cyst (HP:0012062)	2.16776380
59	IgG deficiency (HP:0004315)	2.16651171
60	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.15905248
61	Abnormality of homocysteine metabolism (HP:0010919)	2.15026658
62	Homocystinuria (HP:0002156)	2.15026658
63	Hamartoma of the eye (HP:0010568)	2.13298823
64	Short tibia (HP:0005736)	2.10507660
65	Attenuation of retinal blood vessels (HP:0007843)	2.07894890
66	Impaired smooth pursuit (HP:0007772)	2.07103144
67	Clumsiness (HP:0002312)	2.06300803
68	Goiter (HP:0000853)	2.06208305
69	Type II lissencephaly (HP:0007260)	2.05219770
70	Short phalanx of the thumb (HP:0009660)	2.04691619
71	Abnormality of the renal collecting system (HP:0004742)	2.04328858
72	Hemiparesis (HP:0001269)	2.03719429
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03237218
74	Absent thumb (HP:0009777)	2.02311635
75	Long nose (HP:0003189)	2.02297529
76	Tinnitus (HP:0000360)	2.00881577
77	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.99238649
78	Male pseudohermaphroditism (HP:0000037)	1.99141459
79	Small hand (HP:0200055)	1.98667537
80	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98038083
81	Stenosis of the external auditory canal (HP:0000402)	1.97900757
82	Chronic hepatic failure (HP:0100626)	1.96664620
83	Abnormality of secondary sexual hair (HP:0009888)	1.96358082
84	Abnormality of the axillary hair (HP:0100134)	1.96358082
85	Fused cervical vertebrae (HP:0002949)	1.92573319
86	Abnormal number of erythroid precursors (HP:0012131)	1.92516628
87	Synostosis of carpal bones (HP:0005048)	1.92127157
88	Humeroradial synostosis (HP:0003041)	1.90671789
89	Synostosis involving the elbow (HP:0003938)	1.90671789
90	Abnormality of DNA repair (HP:0003254)	1.90152823
91	Oral leukoplakia (HP:0002745)	1.89607352
92	Optic nerve hypoplasia (HP:0000609)	1.88244614
93	Hypoplasia of the uterus (HP:0000013)	1.87793751
94	Meningioma (HP:0002858)	1.87600359
95	Decreased circulating renin level (HP:0003351)	1.85386642
96	Acute necrotizing encephalopathy (HP:0006965)	1.85089964
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.83790390
98	Absent/shortened dynein arms (HP:0200106)	1.83790390
99	Abnormality of ocular smooth pursuit (HP:0000617)	1.82864098
100	Fibular aplasia (HP:0002990)	1.82490223

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	4.39414133
2	ADRBK2	4.32619754
3	FRK	4.25800244
4	TLK1	3.18133128
5	TAOK3	3.05859868
6	PINK1	2.80144867
7	TXK	2.54191348
8	PRKD2	2.50668737
9	BMPR1B	2.46322287
10	MAP4K2	2.19144026
11	GRK7	2.14847941
12	NUAK1	2.00502534
13	TIE1	1.80163136
14	ACVR1B	1.77786905
15	ZAK	1.68283824
16	STK16	1.54453724
17	WNK3	1.45885788
18	TAF1	1.44300020
19	MAPK13	1.42529331
20	INSRR	1.42275736
21	WNK4	1.40534925
22	TNIK	1.38280426
23	GRK5	1.36957303
24	GRK6	1.36075247
25	BLK	1.35511815
26	DAPK2	1.27130645
27	VRK2	1.24978011
28	TEC	1.20248935
29	IKBKB	1.19925127
30	ADRBK1	1.15425356
31	MAP3K4	1.05897588
32	DYRK2	1.03165851
33	OXSR1	1.03138783
34	VRK1	0.99896689
35	KIT	0.99400393
36	CDC7	0.99104959
37	BCKDK	0.95435460
38	PRKCG	0.92640493
39	CSNK1G1	0.86133596
40	STK39	0.85253043
41	CASK	0.85153521
42	CSNK1G2	0.84910326
43	CSNK1G3	0.82763211
44	PLK2	0.81566512
45	MAPKAPK3	0.79711999
46	SYK	0.78750374
47	MAP3K9	0.75055515
48	ITK	0.72874148
49	MAP2K7	0.72583536
50	RPS6KA5	0.72278182
51	MAPKAPK5	0.72188161
52	PHKG2	0.71722299
53	PHKG1	0.71722299
54	MAP2K6	0.71207549
55	PRKCE	0.71115052
56	CSNK1A1	0.70615077
57	CSNK1A1L	0.65574663
58	FLT3	0.63626295
59	SGK2	0.60921301
60	MAP2K2	0.59486573
61	MUSK	0.59145296
62	PTK2B	0.58670551
63	IKBKE	0.58033478
64	MATK	0.57439000
65	ERBB2	0.55812938
66	PRKACA	0.55437904
67	RPS6KA6	0.54969778
68	IGF1R	0.53364548
69	CAMK2A	0.52712963
70	CAMKK2	0.52380530
71	PAK3	0.51249634
72	LYN	0.50692493
73	NME1	0.47711620
74	PIK3CA	0.45903276
75	PRKCQ	0.45101705
76	OBSCN	0.44383831
77	PRKCA	0.43775808
78	NTRK3	0.42318668
79	PIM1	0.42307026
80	SGK223	0.41433730
81	SGK494	0.41433730
82	CLK1	0.41327672
83	AURKA	0.41134225
84	MAP2K4	0.40840461
85	EIF2AK2	0.40581076
86	SGK1	0.40439269
87	STK11	0.40127113
88	MAPK15	0.39015370
89	LCK	0.38695085
90	DYRK3	0.38590081
91	ABL1	0.36685212
92	MAPK4	0.36572912
93	PLK4	0.36411466
94	CHUK	0.35414086
95	PRKCH	0.35275004
96	NLK	0.35162613
97	ABL2	0.34381510
98	CDK9	0.33683202
99	AKT3	0.33630401
100	PRKCI	0.33548718

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.22018209
2	Nicotine addiction_Homo sapiens_hsa05033	2.71546746
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51039242
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.47535123
5	Phototransduction_Homo sapiens_hsa04744	2.45287207
6	Sulfur metabolism_Homo sapiens_hsa00920	2.38147258
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18272925
8	Homologous recombination_Homo sapiens_hsa03440	2.15121091
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.11101194
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.08869086
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.03765090
12	Parkinsons disease_Homo sapiens_hsa05012	1.94368449
13	Asthma_Homo sapiens_hsa05310	1.84612351
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77380397
15	Morphine addiction_Homo sapiens_hsa05032	1.76663077
16	Ribosome_Homo sapiens_hsa03010	1.76303947
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.69027962
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.62758977
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61464143
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.61018325
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.56847444
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.56177661
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.55697340
24	Taste transduction_Homo sapiens_hsa04742	1.50370629
25	Alzheimers disease_Homo sapiens_hsa05010	1.46393866
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.42553367
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.40822689
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38959706
29	Caffeine metabolism_Homo sapiens_hsa00232	1.29814565
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.26496440
31	Protein export_Homo sapiens_hsa03060	1.25097911
32	RNA polymerase_Homo sapiens_hsa03020	1.24013611
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21621388
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.20392939
35	Graft-versus-host disease_Homo sapiens_hsa05332	1.13893684
36	Huntingtons disease_Homo sapiens_hsa05016	1.12620114
37	Retinol metabolism_Homo sapiens_hsa00830	1.12282798
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.11613888
39	Basal transcription factors_Homo sapiens_hsa03022	1.10446964
40	Allograft rejection_Homo sapiens_hsa05330	1.08420942
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.07923915
42	Serotonergic synapse_Homo sapiens_hsa04726	1.06619866
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06066149
44	RNA degradation_Homo sapiens_hsa03018	1.04924313
45	Melanoma_Homo sapiens_hsa05218	1.02649786
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02381279
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.02329597
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02129293
49	GABAergic synapse_Homo sapiens_hsa04727	1.00899720
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97849182
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.95178012
52	Olfactory transduction_Homo sapiens_hsa04740	0.93401675
53	Circadian entrainment_Homo sapiens_hsa04713	0.93245446
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92919764
55	Insulin secretion_Homo sapiens_hsa04911	0.90661684
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90016709
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89804787
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85359002
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.84646791
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84109140
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82658530
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.79508397
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79146012
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.73805243
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72189374
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70658379
67	Renin secretion_Homo sapiens_hsa04924	0.70492458
68	Type II diabetes mellitus_Homo sapiens_hsa04930	0.69475286
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68257521
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.66688551
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.65801268
72	Salivary secretion_Homo sapiens_hsa04970	0.61963157
73	Cholinergic synapse_Homo sapiens_hsa04725	0.61649807
74	Sulfur relay system_Homo sapiens_hsa04122	0.60099977
75	Peroxisome_Homo sapiens_hsa04146	0.54214464
76	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53923572
77	One carbon pool by folate_Homo sapiens_hsa00670	0.53471167
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51613243
79	DNA replication_Homo sapiens_hsa03030	0.51085222
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51017177
81	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.50779231
82	Cocaine addiction_Homo sapiens_hsa05030	0.50657207
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.50504557
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.48581038
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48182655
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47844392
87	Long-term depression_Homo sapiens_hsa04730	0.46427923
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.46417559
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.45441466
90	Histidine metabolism_Homo sapiens_hsa00340	0.42197071
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41349178
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40962133
93	Purine metabolism_Homo sapiens_hsa00230	0.40392711
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39252887
95	Butanoate metabolism_Homo sapiens_hsa00650	0.38011900
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35988568
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35882713
98	Regulation of autophagy_Homo sapiens_hsa04140	0.35489061
99	Gastric acid secretion_Homo sapiens_hsa04971	0.35065940
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.34706435

GBP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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