GBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.39955690
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.39955690
3antigen processing and presentation of endogenous antigen (GO:0019883)6.77410489
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.72372452
5* cellular response to type I interferon (GO:0071357)5.65999005
6* type I interferon signaling pathway (GO:0060337)5.65999005
7* response to type I interferon (GO:0034340)5.65884510
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.41086071
9negative regulation of cell killing (GO:0031342)5.41086071
10positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.14492449
11positive regulation of interferon-alpha production (GO:0032727)5.10995697
12regulation of interferon-alpha production (GO:0032647)4.81277913
13response to interferon-alpha (GO:0035455)4.76206042
14negative regulation of interleukin-12 production (GO:0032695)4.52550155
15cellular response to interferon-beta (GO:0035458)4.51372608
16positive regulation of gamma-delta T cell activation (GO:0046645)4.36968407
17positive regulation by symbiont of host defense response (GO:0052509)4.28893076
18modulation by symbiont of host defense response (GO:0052031)4.28893076
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28893076
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28893076
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.28893076
22modulation by symbiont of host immune response (GO:0052553)4.28893076
23* interferon-gamma-mediated signaling pathway (GO:0060333)4.25411074
24response to interferon-beta (GO:0035456)4.24795237
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22459000
26cellular response to interferon-alpha (GO:0035457)4.19398723
27regulation of B cell receptor signaling pathway (GO:0050855)4.16875067
28negative regulation of viral genome replication (GO:0045071)4.09648606
29regulation of type I interferon-mediated signaling pathway (GO:0060338)4.07259151
30regulation of interleukin-12 biosynthetic process (GO:0045075)4.04788764
31positive regulation of natural killer cell differentiation (GO:0032825)3.98572900
32immunoglobulin mediated immune response (GO:0016064)3.97601652
33detection of other organism (GO:0098543)3.97373367
34T-helper 1 type immune response (GO:0042088)3.95960233
35regulation of RIG-I signaling pathway (GO:0039535)3.95376980
36defense response to protozoan (GO:0042832)3.90496063
37response to peptidoglycan (GO:0032494)3.89824852
38regulation of T-helper 1 cell differentiation (GO:0045625)3.89320736
39natural killer cell mediated cytotoxicity (GO:0042267)3.88831095
40natural killer cell mediated immunity (GO:0002228)3.88831095
41regulation of interferon-beta biosynthetic process (GO:0045357)3.87572970
42regulation of T cell tolerance induction (GO:0002664)3.86620867
43neutrophil activation involved in immune response (GO:0002283)3.84428112
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.84382757
45detection of molecule of bacterial origin (GO:0032490)3.84038572
46regulation of alpha-beta T cell proliferation (GO:0046640)3.83332571
47myeloid dendritic cell differentiation (GO:0043011)3.78488319
48positive regulation of antigen processing and presentation (GO:0002579)3.77695104
49positive regulation of interferon-beta production (GO:0032728)3.75629190
50T cell migration (GO:0072678)3.74198827
51detection of bacterium (GO:0016045)3.71460146
52response to interleukin-15 (GO:0070672)3.64027306
53detection of external biotic stimulus (GO:0098581)3.60738618
54leukocyte aggregation (GO:0070486)3.60320061
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.59059013
56positive regulation of interleukin-12 production (GO:0032735)3.58741040
57* cellular response to interferon-gamma (GO:0071346)3.57901406
58regulation of tolerance induction (GO:0002643)3.55218531
59response to protozoan (GO:0001562)3.54349552
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.53713192
61myeloid dendritic cell activation (GO:0001773)3.52222240
62negative regulation of T cell mediated immunity (GO:0002710)3.51153266
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50642497
64regulation of regulatory T cell differentiation (GO:0045589)3.47170170
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.43829418
66cellular response to interleukin-15 (GO:0071350)3.43602890
67positive regulation of tolerance induction (GO:0002645)3.42086369
68positive regulation of type 2 immune response (GO:0002830)3.39990657
69positive regulation of humoral immune response (GO:0002922)3.38924813
70positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38626588
71cellular response to virus (GO:0098586)3.37782337
72defense response to virus (GO:0051607)3.35815225
73NIK/NF-kappaB signaling (GO:0038061)3.35736165
74regulation of immunoglobulin secretion (GO:0051023)3.34529681
75regulation of antigen processing and presentation (GO:0002577)3.32469811
76regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.32408804
77response to host immune response (GO:0052572)3.32383646
78response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32383646
79microglial cell activation (GO:0001774)3.29015401
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27896098
81antigen processing and presentation via MHC class Ib (GO:0002475)3.26893780
82positive regulation of chemokine biosynthetic process (GO:0045080)3.24502111
83regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.24255138
84respiratory burst (GO:0045730)3.23500190
85* response to interferon-gamma (GO:0034341)3.23478295
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23334839
87germinal center formation (GO:0002467)3.21105138
88regulation of response to interferon-gamma (GO:0060330)3.19763227
89positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.19715349
90regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19489321
91positive regulation of T cell cytokine production (GO:0002726)3.19477552
92positive thymic T cell selection (GO:0045059)3.18992363
93detection of biotic stimulus (GO:0009595)3.18978242
94lymphocyte chemotaxis (GO:0048247)3.18245064
95macrophage activation involved in immune response (GO:0002281)3.17004688
96B cell mediated immunity (GO:0019724)3.16656051
97cellular response to exogenous dsRNA (GO:0071360)3.14779126
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.13129129
99macrophage activation (GO:0042116)3.12855012
100negative thymic T cell selection (GO:0045060)3.12423847
101regulation of chemokine biosynthetic process (GO:0045073)3.12167811
102negative regulation of leukocyte mediated immunity (GO:0002704)3.11172389
103positive regulation of T-helper cell differentiation (GO:0045624)3.10993683
104cellular extravasation (GO:0045123)3.10973367
105positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.10479319
106myeloid cell activation involved in immune response (GO:0002275)3.09169928
107tolerance induction (GO:0002507)3.09011407
108negative regulation of cytokine production involved in immune response (GO:0002719)3.08056116
109granulocyte activation (GO:0036230)3.06573272
110production of molecular mediator involved in inflammatory response (GO:0002532)3.06220357
111positive regulation of interleukin-17 production (GO:0032740)3.03307763
112regulation of gamma-delta T cell activation (GO:0046643)3.01905659
113regulation of gamma-delta T cell differentiation (GO:0045586)3.01819947
114response to muramyl dipeptide (GO:0032495)3.01591259
115regulation of memory T cell differentiation (GO:0043380)3.01559843
116regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.01478692
117regulation of natural killer cell mediated immunity (GO:0002715)3.01478692
118regulation of T cell mediated cytotoxicity (GO:0001914)3.00841888
119regulation of interleukin-12 production (GO:0032655)3.00749405
120positive regulation of defense response to virus by host (GO:0002230)3.00093337
121response to host (GO:0075136)2.99700745
122response to host defenses (GO:0052200)2.99700745
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99700745
124positive regulation of interleukin-2 production (GO:0032743)2.98903962
125negative T cell selection (GO:0043383)2.97976644
126regulation of T-helper 1 type immune response (GO:0002825)2.97238675
127neutrophil activation (GO:0042119)2.96504694
128regulation of T-helper cell differentiation (GO:0045622)2.96450059
129regulation of hypersensitivity (GO:0002883)2.95823165
130dendritic cell differentiation (GO:0097028)2.95206199
131hydrogen peroxide biosynthetic process (GO:0050665)2.92268233
132positive regulation of response to biotic stimulus (GO:0002833)2.92177282
133positive T cell selection (GO:0043368)2.89322434
134regulation of interleukin-2 biosynthetic process (GO:0045076)2.87578827
135negative regulation of innate immune response (GO:0045824)2.86635994
136positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85181452
137T cell selection (GO:0045058)2.80665802
138regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.79305606
139positive regulation of B cell differentiation (GO:0045579)2.78985786
140interferon-gamma production (GO:0032609)2.78299322
141regulation of B cell differentiation (GO:0045577)2.77280129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.15359658
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.04380253
3* IRF8_21731497_ChIP-ChIP_J774_Mouse6.61524636
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.37536797
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.98481294
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.70500966
7* IRF8_27001747_Chip-Seq_BMDM_Mouse4.02074569
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66618002
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.41286422
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32970755
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32279252
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17304232
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.04565126
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94406069
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73336443
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49966964
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34983853
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34136902
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.33914580
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24590774
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.20161768
22* MYB_26560356_Chip-Seq_TH2_Human2.02734960
23MAF_26560356_Chip-Seq_TH1_Human1.91937260
24RUNX_20019798_ChIP-Seq_JUKART_Human1.89336333
25SPI1_23547873_ChIP-Seq_NB4_Human1.84141638
26GATA1_22025678_ChIP-Seq_K562_Human1.83209069
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80901825
28* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77792837
29* MYB_26560356_Chip-Seq_TH1_Human1.65709731
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62713739
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62273220
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56100732
33VDR_24763502_ChIP-Seq_THP-1_Human1.51567498
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.51220581
35PU_27001747_Chip-Seq_BMDM_Mouse1.48863966
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48547700
37* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45740064
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42969502
39* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40853812
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39263050
41GATA3_27048872_Chip-Seq_THYMUS_Human1.36827292
42VDR_21846776_ChIP-Seq_THP-1_Human1.33364932
43SCL_19346495_ChIP-Seq_HPC-7_Human1.32367299
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31961019
45SPI1_23127762_ChIP-Seq_K562_Human1.30424935
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30341752
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27096333
48VDR_24787735_ChIP-Seq_THP-1_Human1.24734945
49UTX_26944678_Chip-Seq_JUKART_Human1.24588336
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.20556617
51* GATA3_26560356_Chip-Seq_TH2_Human1.17970398
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17233985
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15882698
54* MAF_26560356_Chip-Seq_TH2_Human1.15267951
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14742753
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12919761
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12381088
58GATA1_19941826_ChIP-Seq_K562_Human1.06792759
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06722483
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04303561
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02940746
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01840490
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01575344
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99811372
65* GATA2_21666600_ChIP-Seq_HMVEC_Human0.99195194
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97732767
67ELK3_25401928_ChIP-Seq_HUVEC_Human0.97157753
68* EGR1_19032775_ChIP-ChIP_M12_Human0.97156450
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96869773
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96630898
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92707855
72TCF7_22412390_ChIP-Seq_EML_Mouse0.92281817
73* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91338954
74MYC_22102868_ChIP-Seq_BL_Human0.90292638
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89572105
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86053548
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85831655
78ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82981783
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80961838
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.78359408
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77398310
82PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77212416
83KDM2B_26808549_Chip-Seq_JURKAT_Human0.77111679
84KDM2B_26808549_Chip-Seq_DND41_Human0.75430191
85TRIM28_21343339_ChIP-Seq_HEK293_Human0.74676089
86LXR_22292898_ChIP-Seq_THP-1_Human0.73729437
87BCL6_27268052_Chip-Seq_Bcells_Human0.73490681
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72420077
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72030370
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.71822431
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71634275
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71221181
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71200746
94STAT1_20625510_ChIP-Seq_HELA_Human0.71111012
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70674940
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70176246
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70176246
98* SOX2_20726797_ChIP-Seq_SW620_Human0.70094427
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69693534
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68458104
101* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.68383706
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66556890
103NCOR1_26117541_ChIP-Seq_K562_Human0.66119461
104BCOR_27268052_Chip-Seq_Bcells_Human0.65958582
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64968185
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.64376866
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63961470
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.58626885
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.58595528
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58141076
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57355942
112* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57222962
113SPI1_20517297_ChIP-Seq_HL60_Human0.57090204
114SMRT_27268052_Chip-Seq_Bcells_Human0.56426878
115* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.56375896
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.55571535
117* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.53093706
118GATA2_19941826_ChIP-Seq_K562_Human0.52560604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.02130188
2MP0009785_altered_susceptibility_to4.33201729
3MP0003436_decreased_susceptibility_to3.49658438
4MP0002148_abnormal_hypersensitivity_rea3.44479664
5MP0000685_abnormal_immune_system3.43032539
6MP0005671_abnormal_response_to3.25846856
7MP0003724_increased_susceptibility_to3.22477522
8MP0005025_abnormal_response_to3.22075915
9MP0005387_immune_system_phenotype3.21756211
10MP0001790_abnormal_immune_system3.21756211
11MP0005000_abnormal_immune_tolerance3.15581176
12MP0006082_CNS_inflammation3.11417253
13MP0004510_myositis3.09544592
14MP0001800_abnormal_humoral_immune2.77689881
15MP0003303_peritoneal_inflammation2.74010953
16MP0002419_abnormal_innate_immunity2.72943420
17MP0002723_abnormal_immune_serum2.68428408
18MP0002452_abnormal_antigen_presenting2.67053819
19MP0002006_tumorigenesis2.46433877
20MP0001819_abnormal_immune_cell2.35790639
21MP0002166_altered_tumor_susceptibility2.35148100
22MP0002420_abnormal_adaptive_immunity2.30819260
23MP0004947_skin_inflammation2.28420592
24MP0001853_heart_inflammation1.97144972
25MP0001533_abnormal_skeleton_physiology1.94080803
26MP0003448_altered_tumor_morphology1.91453807
27MP0010155_abnormal_intestine_physiology1.91018360
28MP0001845_abnormal_inflammatory_respons1.87056341
29MP0005464_abnormal_platelet_physiology1.84208031
30MP0002405_respiratory_system_inflammati1.84141323
31MP0009764_decreased_sensitivity_to1.84075255
32MP0003763_abnormal_thymus_physiology1.83693668
33MP0000716_abnormal_immune_system1.78284546
34MP0002398_abnormal_bone_marrow1.77592344
35MP0005058_abnormal_lysosome_morphology1.73612230
36MP0008469_abnormal_protein_level1.73535181
37MP0009333_abnormal_splenocyte_physiolog1.70564125
38MP0005451_abnormal_body_composition1.63661081
39MP0005310_abnormal_salivary_gland1.57073814
40MP0008260_abnormal_autophagy1.55772935
41MP0000343_altered_response_to1.52185586
42MP0003075_altered_response_to1.48761445
43MP0002429_abnormal_blood_cell1.41972799
44MP0000858_altered_metastatic_potential1.38400308
45MP0003300_gastrointestinal_ulcer1.37279349
46MP0000689_abnormal_spleen_morphology1.35371643
47MP0002998_abnormal_bone_remodeling1.31799700
48MP0002722_abnormal_immune_system1.30637532
49MP0005397_hematopoietic_system_phenotyp1.25738960
50MP0001545_abnormal_hematopoietic_system1.25738960
51MP0004782_abnormal_surfactant_physiolog1.23523527
52MP0000604_amyloidosis1.22288030
53MP0009278_abnormal_bone_marrow1.21428299
54MP0003191_abnormal_cellular_cholesterol1.18894635
55MP0002138_abnormal_hepatobiliary_system1.17078650
56MP0004883_abnormal_blood_vessel1.14861452
57MP0008004_abnormal_stomach_pH1.13919663
58MP0005166_decreased_susceptibility_to1.10986949
59MP0009840_abnormal_foam_cell1.08565844
60MP0004808_abnormal_hematopoietic_stem1.08453070
61MP0003183_abnormal_peptide_metabolism1.06450374
62MP0009763_increased_sensitivity_to1.04342187
63MP0003172_abnormal_lysosome_physiology1.03967630
64MP0010307_abnormal_tumor_latency1.03637351
65MP0003866_abnormal_defecation0.98443015
66MP0002132_abnormal_respiratory_system0.95468922
67MP0005164_abnormal_response_to0.95216188
68MP0005167_abnormal_blood-brain_barrier0.95204380
69MP0001663_abnormal_digestive_system0.93720539
70MP0002933_joint_inflammation0.93437289
71MP0001851_eye_inflammation0.92363069
72MP0004381_abnormal_hair_follicle0.92331484
73MP0000703_abnormal_thymus_morphology0.92240426
74MP0003656_abnormal_erythrocyte_physiolo0.91906468
75MP0002254_reproductive_system_inflammat0.91886805
76MP0002277_abnormal_respiratory_mucosa0.90497485
77MP0003091_abnormal_cell_migration0.90057526
78MP0004858_abnormal_nervous_system0.90011376
79MP0003186_abnormal_redox_activity0.89374773
80MP0003806_abnormal_nucleotide_metabolis0.88906197
81MP0005390_skeleton_phenotype0.87975177
82MP0003566_abnormal_cell_adhesion0.83670156
83MP0001873_stomach_inflammation0.83509599
84MP0003690_abnormal_glial_cell0.82297638
85MP0003453_abnormal_keratinocyte_physiol0.81382108
86MP0002139_abnormal_hepatobiliary_system0.80409675
87MP0003045_fibrosis0.78959132
88MP0000249_abnormal_blood_vessel0.78300869
89MP0003828_pulmonary_edema0.78019803
90MP0006054_spinal_hemorrhage0.75952609
91MP0001881_abnormal_mammary_gland0.74387237
92MP0002396_abnormal_hematopoietic_system0.73849737
93MP0001348_abnormal_lacrimal_gland0.72913066
94MP0010352_gastrointestinal_tract_polyps0.72315042
95MP0003221_abnormal_cardiomyocyte_apopto0.70415038
96MP0005023_abnormal_wound_healing0.69815099
97MP0003705_abnormal_hypodermis_morpholog0.66574991
98MP0002136_abnormal_kidney_physiology0.65365164
99MP0000569_abnormal_digit_pigmentation0.63268666
100MP0002332_abnormal_exercise_endurance0.61052487
101MP0008438_abnormal_cutaneous_collagen0.60934774
102MP0008874_decreased_physiological_sensi0.60666002
103MP0005076_abnormal_cell_differentiation0.58863989
104MP0003195_calcinosis0.58073484
105MP0001958_emphysema0.57996987
106MP0000490_abnormal_crypts_of0.56963923
107MP0000465_gastrointestinal_hemorrhage0.56936024
108MP0009765_abnormal_xenobiotic_induced0.56795291
109MP0000609_abnormal_liver_physiology0.55991661
110MP0000627_abnormal_mammary_gland0.55958847
111MP0003795_abnormal_bone_structure0.54433691
112MP0002019_abnormal_tumor_incidence0.53633062
113MP0005319_abnormal_enzyme/_coenzyme0.53411055
114MP0003329_amyloid_beta_deposits0.52930880
115MP0002163_abnormal_gland_morphology0.52725761
116MP0005381_digestive/alimentary_phenotyp0.51957075
117MP0000371_diluted_coat_color0.51933559
118MP0002693_abnormal_pancreas_physiology0.51346066
119MP0001216_abnormal_epidermal_layer0.49330317

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.30688743
2Chronic otitis media (HP:0000389)6.08734667
3Elevated erythrocyte sedimentation rate (HP:0003565)5.99803772
4Recurrent abscess formation (HP:0002722)5.79936541
5Recurrent bacterial skin infections (HP:0005406)5.52654121
6Autoimmune thrombocytopenia (HP:0001973)4.98748529
7Nasal polyposis (HP:0100582)4.72085873
8Myositis (HP:0100614)4.68866207
9Increased IgM level (HP:0003496)4.64202495
10Mediastinal lymphadenopathy (HP:0100721)4.61521521
11Recurrent gram-negative bacterial infections (HP:0005420)4.49627583
12Abnormality of the nasal mucosa (HP:0000433)4.49566294
13Abnormality of macrophages (HP:0004311)4.28192272
14Orchitis (HP:0100796)4.25580479
15Recurrent bronchitis (HP:0002837)4.11629397
16Recurrent viral infections (HP:0004429)4.04389275
17Stomatitis (HP:0010280)4.03256038
18Recurrent fungal infections (HP:0002841)4.02873864
19Vasculitis (HP:0002633)3.97020003
20Recurrent skin infections (HP:0001581)3.87582421
21Optic neuritis (HP:0100653)3.84648635
22Retrobulbar optic neuritis (HP:0100654)3.84648635
23Basal ganglia calcification (HP:0002135)3.78758074
24Systemic lupus erythematosus (HP:0002725)3.65774947
25Encephalitis (HP:0002383)3.57141936
26Chronic sinusitis (HP:0011109)3.52472464
27Hypergammaglobulinemia (HP:0010702)3.43276856
28Gastrointestinal infarctions (HP:0005244)3.41063964
29Recurrent cutaneous fungal infections (HP:0011370)3.38320931
30Chronic mucocutaneous candidiasis (HP:0002728)3.38320931
31Pustule (HP:0200039)3.34872995
32Interstitial pulmonary disease (HP:0006530)3.33822186
33Gingivitis (HP:0000230)3.31161647
34Abnormality of T cell number (HP:0011839)3.30317751
35Thick nail (HP:0001805)3.28474571
36Obstructive lung disease (HP:0006536)3.07203753
37Chronic obstructive pulmonary disease (HP:0006510)3.07203753
38Autoimmune hemolytic anemia (HP:0001890)3.06412635
39Porencephaly (HP:0002132)3.03954732
40T lymphocytopenia (HP:0005403)3.00751130
41Cellulitis (HP:0100658)2.99958362
42Hemoptysis (HP:0002105)2.98013660
43Abnormality of glycolipid metabolism (HP:0010969)2.97544873
44Abnormality of liposaccharide metabolism (HP:0010968)2.97544873
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.97544873
46Pulmonary infiltrates (HP:0002113)2.96053037
47Periodontitis (HP:0000704)2.95146713
48Abnormality of T cells (HP:0002843)2.90305373
49Increased cerebral lipofuscin (HP:0011813)2.86465977
50Tetraparesis (HP:0002273)2.84378172
51Pulmonary embolism (HP:0002204)2.80356520
52Spontaneous hematomas (HP:0007420)2.75113168
53Arterial thrombosis (HP:0004420)2.74774980
54Vacuolated lymphocytes (HP:0001922)2.70349395
55Abnormality of T cell physiology (HP:0011840)2.67721366
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63107635
57Gingival bleeding (HP:0000225)2.61708557
58Leukocytosis (HP:0001974)2.61021967
59Hematochezia (HP:0002573)2.58640209
60Meningitis (HP:0001287)2.56906448
61Prostate neoplasm (HP:0100787)2.54437336
62Emphysema (HP:0002097)2.52074835
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.49903555
64Thrombocytosis (HP:0001894)2.49360639
65Keratoconjunctivitis sicca (HP:0001097)2.47963883
66Increased IgE level (HP:0003212)2.47677526
67Urticaria (HP:0001025)2.44735966
68Joint swelling (HP:0001386)2.43579184
69Amyloidosis (HP:0011034)2.42564610
70IgA deficiency (HP:0002720)2.42221242
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.40412893
72Chronic diarrhea (HP:0002028)2.39947532
73Skin ulcer (HP:0200042)2.38572727
74Chest pain (HP:0100749)2.37626092
75Episodic fever (HP:0001954)2.31792963
76IgG deficiency (HP:0004315)2.31150174
77Glomerulopathy (HP:0100820)2.28885544
78Premature loss of primary teeth (HP:0006323)2.28606223
79Loss of speech (HP:0002371)2.27812826
80Myocardial infarction (HP:0001658)2.26919854
81Gastrointestinal inflammation (HP:0004386)2.26140462
82Osteolytic defects of the hand bones (HP:0009699)2.25337357
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.25337357
84Bronchitis (HP:0012387)2.25245946
85Colitis (HP:0002583)2.25002354
86Keratoconjunctivitis (HP:0001096)2.24152425
87Eosinophilia (HP:0001880)2.22145281
88Peritonitis (HP:0002586)2.19921734
89Polyneuropathy (HP:0001271)2.18700184
90Osteomyelitis (HP:0002754)2.18615053
91Prolonged bleeding time (HP:0003010)2.18488325
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.17256488
93Petechiae (HP:0000967)2.15890403
94Anorexia (HP:0002039)2.14133785
95Gangrene (HP:0100758)2.13438275
96Keratitis (HP:0000491)2.13048667
97Lymphopenia (HP:0001888)2.12803904
98Increased serum ferritin (HP:0003281)2.12138782
99Dysostosis multiplex (HP:0000943)2.12103110
100Abnormality of the endocardium (HP:0004306)2.11386104
101Acne (HP:0001061)2.11146075
102Granulocytopenia (HP:0001913)2.09962041
103Recurrent pneumonia (HP:0006532)2.09203718
104Vertigo (HP:0002321)2.09130643
105Purpura (HP:0000979)2.09080093
106Recurrent lower respiratory tract infections (HP:0002783)2.08528910
107Abnormality of the pericardium (HP:0001697)2.08422171
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06569012
109Arthralgia (HP:0002829)2.06454672
110Abnormality of the pleura (HP:0002103)2.05849786
111Hepatosplenomegaly (HP:0001433)2.05521436
112Axonal loss (HP:0003447)2.04070394
113Disinhibition (HP:0000734)2.03546112
114Malnutrition (HP:0004395)2.03275107
115Glomerulonephritis (HP:0000099)2.03171173
116Cleft eyelid (HP:0000625)2.01497675
117Hypochromic anemia (HP:0001931)2.00098332
118Inflammation of the large intestine (HP:0002037)1.99231204
119Panhypogammaglobulinemia (HP:0003139)1.98927902
120Abnormality of the peritoneum (HP:0002585)1.98426097
121Nephritis (HP:0000123)1.97313614
122Abnormality of B cell number (HP:0010975)1.96236494
123Esophageal varix (HP:0002040)1.95675275
124Epistaxis (HP:0000421)1.95296837
125Abnormality of eosinophils (HP:0001879)1.94845513
126Thrombophlebitis (HP:0004418)1.94690256
127Acute hepatic failure (HP:0006554)1.94426613
128Slow saccadic eye movements (HP:0000514)1.93966335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.35517665
2MAP3K144.32545673
3JAK33.79761775
4TBK13.55763250
5IKBKE3.51537447
6FGFR43.49582497
7MAP4K13.35071446
8BLK3.34988498
9KIT2.95374805
10JAK12.90723009
11TXK2.81073543
12RIPK42.53509050
13PBK2.46661163
14IKBKB2.30384176
15FGFR32.18834700
16ERN12.16455491
17MAP3K132.15509334
18IRAK42.10880818
19PRPF4B2.07511141
20ZAP701.99608976
21IRAK31.87559647
22PIM21.84371432
23CHUK1.62144261
24EPHA31.54534074
25GRK61.52674698
26EPHB11.52392889
27TAOK11.45907050
28NME21.45789442
29SYK1.41425692
30CSK1.37570622
31HCK1.32215856
32TAOK21.31843870
33LCK1.29376573
34TNK21.23665028
35MST41.22341697
36NEK91.22258158
37JAK21.22087765
38CSF1R1.06844370
39ITK1.06208555
40TEC1.03525811
41RPS6KA41.02788538
42BTK1.01973555
43STK101.01886964
44LYN0.98490022
45TGFBR20.95691054
46BMX0.94305271
47PIM10.87272182
48CDC42BPA0.86868569
49IRAK20.85227233
50EIF2AK20.81857508
51NLK0.80263256
52TIE10.78157778
53MAP2K60.76855500
54LRRK20.75685913
55PRKCQ0.75220587
56FGR0.73605721
57HIPK20.69781635
58FES0.68975004
59EGFR0.68116003
60CAMKK20.67081125
61TRIB30.66722286
62IRAK10.63858925
63TESK20.62338519
64TGFBR10.61873457
65RIPK10.60051080
66PIK3CG0.59697449
67STK40.59122279
68ARAF0.57927397
69MATK0.57291303
70MARK30.56672527
71ABL20.55996997
72KSR20.55432963
73MAPK70.55340849
74MARK20.55261236
75BMPR20.53115732
76MAP3K50.52427080
77MAP3K60.51894177
78ABL10.50902327
79CLK10.50592022
80KDR0.49490886
81PDPK10.49489916
82TAOK30.48888886
83DDR20.48775781
84MST1R0.46833582
85PTK60.45009252
86PRKCD0.44411987
87ACVR1B0.43989468
88SGK30.41836540
89TRPM70.40893735
90RPS6KA50.40132521
91MAP3K20.39573660
92MAPK110.39524129
93EEF2K0.39253353
94PDGFRB0.36574070
95MAP3K100.34909106
96MAP3K10.34808781
97PKN20.34173578
98TYRO30.34107097
99TTN0.33990080
100MOS0.33987632
101ALK0.33034918
102MAPK120.32753840
103PRKD20.32390997
104SIK20.32162935
105MAPKAPK20.30151584
106DYRK1B0.30139914
107PTK2B0.28691442
108MAP2K30.28626548
109MAP3K70.28461224
110SGK20.27840655
111RET0.27250902
112RPS6KC10.26915887
113RPS6KL10.26915887
114FLT30.26464658
115CAMKK10.25663154
116CDK120.25641114
117FYN0.25506319
118CDK60.25104045
119PDK10.24522803
120PRKCH0.24495671
121SIK30.24239937
122IGF1R0.24148647
123RAF10.23099480
124YES10.22729574
125MAP3K110.21245521
126INSR0.20453396
127SRC0.17360055
128CDK40.16550829
129MAP3K30.15854191
130STK30.15584759
131GRK70.15260526
132DAPK30.14923027

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.28892211
2Allograft rejection_Homo sapiens_hsa053303.21994014
3Leishmaniasis_Homo sapiens_hsa051403.12989772
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.07338831
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.91226361
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.81464221
7Measles_Homo sapiens_hsa051622.78360860
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.69282260
9Staphylococcus aureus infection_Homo sapiens_hsa051502.39286024
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39034860
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.36941444
12Legionellosis_Homo sapiens_hsa051342.33072327
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.27924569
14Pertussis_Homo sapiens_hsa051332.25229586
15Influenza A_Homo sapiens_hsa051642.22521700
16Primary immunodeficiency_Homo sapiens_hsa053402.16262005
17Osteoclast differentiation_Homo sapiens_hsa043802.15931728
18Herpes simplex infection_Homo sapiens_hsa051682.12750836
19Type I diabetes mellitus_Homo sapiens_hsa049402.08988079
20Malaria_Homo sapiens_hsa051442.07634386
21TNF signaling pathway_Homo sapiens_hsa046681.96056903
22Antigen processing and presentation_Homo sapiens_hsa046121.92352519
23Autoimmune thyroid disease_Homo sapiens_hsa053201.84842682
24Toxoplasmosis_Homo sapiens_hsa051451.83293565
25Tuberculosis_Homo sapiens_hsa051521.82832267
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.75461136
27African trypanosomiasis_Homo sapiens_hsa051431.70661761
28Asthma_Homo sapiens_hsa053101.69058558
29Rheumatoid arthritis_Homo sapiens_hsa053231.63950518
30Viral myocarditis_Homo sapiens_hsa054161.60475285
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50635374
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46582624
33Salmonella infection_Homo sapiens_hsa051321.46460669
34B cell receptor signaling pathway_Homo sapiens_hsa046621.43098399
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43050756
36Apoptosis_Homo sapiens_hsa042101.41454647
37Hepatitis C_Homo sapiens_hsa051601.40821602
38Chemokine signaling pathway_Homo sapiens_hsa040621.40415659
39Hematopoietic cell lineage_Homo sapiens_hsa046401.37242556
40T cell receptor signaling pathway_Homo sapiens_hsa046601.27197360
41Hepatitis B_Homo sapiens_hsa051611.24919747
42Shigellosis_Homo sapiens_hsa051311.19842908
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09463031
44Phagosome_Homo sapiens_hsa041451.03735846
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99987034
46Lysosome_Homo sapiens_hsa041420.96064068
47Prolactin signaling pathway_Homo sapiens_hsa049170.96002019
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88455210
49Acute myeloid leukemia_Homo sapiens_hsa052210.87925304
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83769726
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.81216447
52Amoebiasis_Homo sapiens_hsa051460.75305479
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.72702967
54Prion diseases_Homo sapiens_hsa050200.72336654
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71548487
56Non-small cell lung cancer_Homo sapiens_hsa052230.69340018
57HIF-1 signaling pathway_Homo sapiens_hsa040660.67462555
58Small cell lung cancer_Homo sapiens_hsa052220.65428517
59Caffeine metabolism_Homo sapiens_hsa002320.64957223
60Chronic myeloid leukemia_Homo sapiens_hsa052200.63993042
61Epstein-Barr virus infection_Homo sapiens_hsa051690.63651001
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63388520
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61199772
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.59525829
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58589171
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58048414
67Platelet activation_Homo sapiens_hsa046110.56401249
68Pancreatic cancer_Homo sapiens_hsa052120.55359408
69Viral carcinogenesis_Homo sapiens_hsa052030.53582144
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.52299398
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47565644
72Proteasome_Homo sapiens_hsa030500.46488613
73HTLV-I infection_Homo sapiens_hsa051660.45115226
74Other glycan degradation_Homo sapiens_hsa005110.44579788
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42592333
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40181768
77Insulin resistance_Homo sapiens_hsa049310.37323512
78Complement and coagulation cascades_Homo sapiens_hsa046100.36645769
79VEGF signaling pathway_Homo sapiens_hsa043700.36225935
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.32544243
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31166825
82Notch signaling pathway_Homo sapiens_hsa043300.30200931
83Proteoglycans in cancer_Homo sapiens_hsa052050.27555678
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.26427858
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26060533
86GnRH signaling pathway_Homo sapiens_hsa049120.24545131
87Bladder cancer_Homo sapiens_hsa052190.24354245
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24327659
89mTOR signaling pathway_Homo sapiens_hsa041500.23842977
90Type II diabetes mellitus_Homo sapiens_hsa049300.23806141
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23692523
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23004426
93p53 signaling pathway_Homo sapiens_hsa041150.21425178
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21365999
95Choline metabolism in cancer_Homo sapiens_hsa052310.18708895
96Prostate cancer_Homo sapiens_hsa052150.18583796
97MicroRNAs in cancer_Homo sapiens_hsa052060.17905674
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17346601
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17058028
100Endometrial cancer_Homo sapiens_hsa052130.16432092
101Systemic lupus erythematosus_Homo sapiens_hsa053220.16228286
102Renin-angiotensin system_Homo sapiens_hsa046140.15820497
103Inositol phosphate metabolism_Homo sapiens_hsa005620.13971250
104Dorso-ventral axis formation_Homo sapiens_hsa043200.11982314
105Endocytosis_Homo sapiens_hsa041440.10306624
106ABC transporters_Homo sapiens_hsa020100.09733758
107FoxO signaling pathway_Homo sapiens_hsa040680.09726065
108Pathways in cancer_Homo sapiens_hsa052000.07430009
109Focal adhesion_Homo sapiens_hsa045100.07315516
110Mineral absorption_Homo sapiens_hsa049780.07201481
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06942933
112MAPK signaling pathway_Homo sapiens_hsa040100.06898771
113Renal cell carcinoma_Homo sapiens_hsa052110.06023166
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05735243

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