GBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.94517663
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.94517663
3antigen processing and presentation of endogenous antigen (GO:0019883)8.16585049
4positive regulation of gamma-delta T cell activation (GO:0046645)6.51740792
5negative T cell selection (GO:0043383)6.01658536
6negative thymic T cell selection (GO:0045060)5.80682542
7response to type I interferon (GO:0034340)5.58900638
8cellular response to type I interferon (GO:0071357)5.51670277
9type I interferon signaling pathway (GO:0060337)5.51670277
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.32099302
11negative regulation of cell killing (GO:0031342)5.30147204
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30147204
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.21242129
14regulation of gamma-delta T cell differentiation (GO:0045586)5.14472096
15positive thymic T cell selection (GO:0045059)5.09709202
16interferon-gamma production (GO:0032609)5.08418827
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.99580664
18regulation of gamma-delta T cell activation (GO:0046643)4.87646020
19positive T cell selection (GO:0043368)4.85143432
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78957010
21T cell selection (GO:0045058)4.77281779
22regulation of isotype switching to IgG isotypes (GO:0048302)4.76487717
23regulation of T cell tolerance induction (GO:0002664)4.76045602
24T cell migration (GO:0072678)4.70364904
25thymic T cell selection (GO:0045061)4.70116361
26cellular response to interleukin-15 (GO:0071350)4.64734811
27cellular response to interferon-beta (GO:0035458)4.61042135
28response to interleukin-15 (GO:0070672)4.60570348
29regulation of interleukin-12 biosynthetic process (GO:0045075)4.58617568
30regulation of alpha-beta T cell proliferation (GO:0046640)4.34604111
31regulation of regulatory T cell differentiation (GO:0045589)4.27512010
32negative regulation of interleukin-12 production (GO:0032695)4.26853666
33regulation of type I interferon-mediated signaling pathway (GO:0060338)4.26425830
34interferon-gamma-mediated signaling pathway (GO:0060333)4.20183056
35leukocyte aggregation (GO:0070486)4.04764352
36regulation of B cell receptor signaling pathway (GO:0050855)4.00478972
37positive regulation of type 2 immune response (GO:0002830)3.97112914
38regulation of MHC class I biosynthetic process (GO:0045343)3.92903438
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.92066506
40T cell receptor signaling pathway (GO:0050852)3.89422721
41positive regulation of humoral immune response (GO:0002922)3.88948917
42T cell costimulation (GO:0031295)3.87678257
43response to interferon-beta (GO:0035456)3.84783387
44lymphocyte costimulation (GO:0031294)3.82859324
45positive regulation of alpha-beta T cell proliferation (GO:0046641)3.80951492
46immunoglobulin mediated immune response (GO:0016064)3.78498129
47positive regulation of interleukin-2 production (GO:0032743)3.74814936
48positive regulation of isotype switching (GO:0045830)3.69757091
49regulation of response to interferon-gamma (GO:0060330)3.65973379
50antigen processing and presentation via MHC class Ib (GO:0002475)3.60068763
51regulation of chronic inflammatory response (GO:0002676)3.59274309
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.58267075
53regulation of interleukin-2 biosynthetic process (GO:0045076)3.57751743
54NIK/NF-kappaB signaling (GO:0038061)3.57114637
55tryptophan catabolic process (GO:0006569)3.55728069
56indole-containing compound catabolic process (GO:0042436)3.55728069
57indolalkylamine catabolic process (GO:0046218)3.55728069
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55721603
59positive regulation by organism of defense response of other organism involved in symbiotic interact3.55721603
60modulation by symbiont of host immune response (GO:0052553)3.55721603
61positive regulation by symbiont of host defense response (GO:0052509)3.55721603
62modulation by symbiont of host defense response (GO:0052031)3.55721603
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55721603
64JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.53550187
65myeloid dendritic cell differentiation (GO:0043011)3.52848363
66regulation of T cell receptor signaling pathway (GO:0050856)3.52514615
67positive regulation of defense response to virus by host (GO:0002230)3.50492007
68regulation of tolerance induction (GO:0002643)3.49918698
69antigen receptor-mediated signaling pathway (GO:0050851)3.49543556
70myeloid dendritic cell activation (GO:0001773)3.46529317
71response to interferon-alpha (GO:0035455)3.42994283
72positive regulation of antigen processing and presentation (GO:0002579)3.42650589
73regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.42252362
74regulation of type 2 immune response (GO:0002828)3.41743951
75kynurenine metabolic process (GO:0070189)3.40467448
76alpha-beta T cell activation (GO:0046631)3.39078014
77macrophage activation involved in immune response (GO:0002281)3.37881101
78lymphocyte chemotaxis (GO:0048247)3.33752077
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31843435
80positive regulation of cAMP-mediated signaling (GO:0043950)3.31821553
81positive regulation of interferon-alpha production (GO:0032727)3.31241779
82positive regulation of immunoglobulin mediated immune response (GO:0002891)3.30570714
83positive regulation of B cell mediated immunity (GO:0002714)3.30570714
84positive regulation of DNA recombination (GO:0045911)3.29401966
85detection of other organism (GO:0098543)3.28597769
86tolerance induction (GO:0002507)3.28235475
87cellular response to interferon-gamma (GO:0071346)3.25997917
88response to interferon-gamma (GO:0034341)3.25339252
89regulation of interleukin-12 production (GO:0032655)3.23909820
90positive regulation of tolerance induction (GO:0002645)3.23899807
91activated T cell proliferation (GO:0050798)3.23630360
92alpha-beta T cell differentiation (GO:0046632)3.22879406
93mast cell activation (GO:0045576)3.22034064
94regulation of interferon-alpha production (GO:0032647)3.20438504
95regulation of interferon-beta biosynthetic process (GO:0045357)3.19673635
96regulation of T-helper 1 cell differentiation (GO:0045625)3.19528371
97response to peptidoglycan (GO:0032494)3.17057406
98regulation of isotype switching (GO:0045191)3.15008683
99T-helper 1 type immune response (GO:0042088)3.14715343
100negative regulation of T cell mediated immunity (GO:0002710)3.12319446
101response to protozoan (GO:0001562)3.11142358
102negative regulation of type 2 immune response (GO:0002829)3.10542430
103regulation of memory T cell differentiation (GO:0043380)3.10197990
104detection of bacterium (GO:0016045)3.09968266
105natural killer cell activation (GO:0030101)3.08776732
106regulation of antigen processing and presentation (GO:0002577)3.07466610
107B cell mediated immunity (GO:0019724)3.06594494
108negative regulation of viral genome replication (GO:0045071)3.06371107
109cellular response to exogenous dsRNA (GO:0071360)3.06092950
110T cell proliferation (GO:0042098)3.05633321
111interferon-gamma secretion (GO:0072643)3.04560080
112cellular response to interferon-alpha (GO:0035457)3.04037118
113negative regulation of lymphocyte mediated immunity (GO:0002707)3.03657990
114tryptophan metabolic process (GO:0006568)3.03456995
115production of molecular mediator involved in inflammatory response (GO:0002532)3.02499803
116positive regulation of T cell cytokine production (GO:0002726)3.02172944
117positive regulation of natural killer cell differentiation (GO:0032825)3.01597575
118regulation of leukocyte mediated cytotoxicity (GO:0001910)3.00164931
119positive regulation of interferon-beta production (GO:0032728)2.97521784
120positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.97089406
121positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.96712239
122leukocyte cell-cell adhesion (GO:0007159)2.96679362
123regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.95904122
124lymphocyte migration (GO:0072676)2.94948870
125regulation of T cell mediated cytotoxicity (GO:0001914)2.94349510
126regulation of immunoglobulin mediated immune response (GO:0002889)2.94166508
127regulation of alpha-beta T cell activation (GO:0046634)2.93959557
128regulation of T-helper cell differentiation (GO:0045622)2.93635560
129regulation of interleukin-1 beta secretion (GO:0050706)2.93620677
130positive regulation of interleukin-1 beta secretion (GO:0050718)2.92860031
131germinal center formation (GO:0002467)2.92621462
132defense response to virus (GO:0051607)2.91099398
133regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90054593
134positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.89599072
135positive regulation of interleukin-12 production (GO:0032735)2.88375614
136defense response to protozoan (GO:0042832)2.86755817
137tumor necrosis factor-mediated signaling pathway (GO:0033209)2.86640760
138regulation of B cell mediated immunity (GO:0002712)2.85741828
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.85405132
140regulation of RIG-I signaling pathway (GO:0039535)2.84381635
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83946999
142T cell homeostasis (GO:0043029)2.83728169
143regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.82154071
144negative regulation of cytokine production involved in immune response (GO:0002719)2.81423121
145positive regulation of T-helper cell differentiation (GO:0045624)2.80320615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.13441012
2IRF8_22096565_ChIP-ChIP_GC-B_Human7.03522020
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.44084339
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.66581757
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.25896573
6IRF8_21731497_ChIP-ChIP_J774_Mouse5.04263148
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.05524164
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.74115727
9RUNX_20019798_ChIP-Seq_JUKART_Human3.50754189
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.18008667
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.16206928
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98140624
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98112066
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80691070
15* MYB_26560356_Chip-Seq_TH2_Human2.74355321
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54951820
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54840849
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42829418
19MAF_26560356_Chip-Seq_TH1_Human2.38525687
20MYB_26560356_Chip-Seq_TH1_Human2.23354855
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16209472
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98734055
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.88771115
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82023244
25UTX_26944678_Chip-Seq_JUKART_Human1.81758710
26SCL_19346495_ChIP-Seq_HPC-7_Human1.80597691
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76751815
28* GATA3_27048872_Chip-Seq_THYMUS_Human1.75267299
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74160612
30SPI1_23547873_ChIP-Seq_NB4_Human1.60960634
31MAF_26560356_Chip-Seq_TH2_Human1.55928327
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55219336
33MYC_22102868_ChIP-Seq_BL_Human1.52264652
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.49754381
35VDR_24763502_ChIP-Seq_THP-1_Human1.45055782
36PU_27001747_Chip-Seq_BMDM_Mouse1.40538429
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39033613
38SPI1_23127762_ChIP-Seq_K562_Human1.32743632
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32529067
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31328880
41* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29018066
42VDR_21846776_ChIP-Seq_THP-1_Human1.28890725
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28119204
44* GATA3_26560356_Chip-Seq_TH2_Human1.27838369
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.27522159
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.24759813
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24383163
48EGR1_19032775_ChIP-ChIP_M12_Human1.24211459
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22378026
50VDR_24787735_ChIP-Seq_THP-1_Human1.22376020
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21293993
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21104950
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20475219
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17429011
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16885854
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13923537
57GATA1_22025678_ChIP-Seq_K562_Human1.12811878
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.11036275
59TCF7_22412390_ChIP-Seq_EML_Mouse1.09717416
60VDR_22108803_ChIP-Seq_LS180_Human1.08973682
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08941054
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08407636
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05057651
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02438295
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98773317
66KDM2B_26808549_Chip-Seq_DND41_Human0.98450928
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98251197
68KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97872623
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95484449
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94217709
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91369519
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90953644
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90903515
74PRDM14_20953172_ChIP-Seq_ESCs_Human0.90360295
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88228217
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88021555
77* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87562360
78STAT1_20625510_ChIP-Seq_HELA_Human0.87343053
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83307837
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82907002
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80174998
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79953815
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.78740759
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77515940
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76986597
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76952556
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76312244
88ER_23166858_ChIP-Seq_MCF-7_Human0.75207776
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74723682
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73943429
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73140991
92GATA1_19941826_ChIP-Seq_K562_Human0.72779503
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.72108431
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71929598
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71106882
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71084330
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70702398
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70418891
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.70205428
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.69538260
101CDX2_22108803_ChIP-Seq_LS180_Human0.68932498
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68712885
103OCT4_21477851_ChIP-Seq_ESCs_Mouse0.68237597
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.67540422
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.67440441
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66406782
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.66070305
108CEBPB_22108803_ChIP-Seq_LS180_Human0.64504025
109BCAT_22108803_ChIP-Seq_LS180_Human0.64135563
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.63397457
111ELF1_17652178_ChIP-ChIP_JURKAT_Human0.63037975
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.62804603
113* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62019684
114GATA2_19941826_ChIP-Seq_K562_Human0.61145775
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61010574
116KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.58305940
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.57580439
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.56094183
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.53590664
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.53555860
121GATA3_26560356_Chip-Seq_TH1_Human0.52544076
122SMRT_27268052_Chip-Seq_Bcells_Human0.52040984
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.52024285
124SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.51791865
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.50930097
126ETS1_22383799_ChIP-Seq_G1ME_Mouse0.50341547
127RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.50087044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.72767063
2MP0005671_abnormal_response_to4.25976762
3MP0000685_abnormal_immune_system4.02625709
4MP0003763_abnormal_thymus_physiology3.89928793
5MP0009785_altered_susceptibility_to3.63204505
6MP0001790_abnormal_immune_system3.47417339
7MP0005387_immune_system_phenotype3.47417339
8MP0003724_increased_susceptibility_to3.40275429
9MP0002166_altered_tumor_susceptibility3.28933842
10MP0001800_abnormal_humoral_immune3.23848280
11MP0004510_myositis3.22553766
12MP0005000_abnormal_immune_tolerance3.08564399
13MP0006082_CNS_inflammation2.97941819
14MP0005025_abnormal_response_to2.92570353
15MP0002723_abnormal_immune_serum2.88803643
16MP0002006_tumorigenesis2.78433773
17MP0002452_abnormal_antigen_presenting2.72793593
18MP0001819_abnormal_immune_cell2.68113906
19MP0002420_abnormal_adaptive_immunity2.67453572
20MP0002148_abnormal_hypersensitivity_rea2.60576608
21MP0003436_decreased_susceptibility_to2.60115254
22MP0009333_abnormal_splenocyte_physiolog2.33589688
23MP0002398_abnormal_bone_marrow2.31833443
24MP0003303_peritoneal_inflammation2.29753729
25MP0002419_abnormal_innate_immunity2.21576047
26MP0000716_abnormal_immune_system2.20174476
27MP0002405_respiratory_system_inflammati2.18243966
28MP0004947_skin_inflammation2.12075382
29MP0010155_abnormal_intestine_physiology2.04929991
30MP0001873_stomach_inflammation1.98651569
31MP0001853_heart_inflammation1.94208902
32MP0000703_abnormal_thymus_morphology1.85148196
33MP0005310_abnormal_salivary_gland1.84166493
34MP0002722_abnormal_immune_system1.80003167
35MP0000689_abnormal_spleen_morphology1.78178764
36MP0003300_gastrointestinal_ulcer1.74689996
37MP0003195_calcinosis1.72482936
38MP0002429_abnormal_blood_cell1.72310886
39MP0001845_abnormal_inflammatory_respons1.71450866
40MP0003866_abnormal_defecation1.69340252
41MP0005464_abnormal_platelet_physiology1.65512707
42MP0002138_abnormal_hepatobiliary_system1.53941674
43MP0003448_altered_tumor_morphology1.52148847
44MP0002396_abnormal_hematopoietic_system1.50291283
45MP0000569_abnormal_digit_pigmentation1.43635666
46MP0001533_abnormal_skeleton_physiology1.41957652
47MP0008469_abnormal_protein_level1.39730399
48MP0003646_muscle_fatigue1.34338881
49MP0002933_joint_inflammation1.26067868
50MP0004381_abnormal_hair_follicle1.25489193
51MP0002998_abnormal_bone_remodeling1.23387850
52MP0001851_eye_inflammation1.21880031
53MP0001501_abnormal_sleep_pattern1.19622362
54MP0002254_reproductive_system_inflammat1.15724892
55MP0005451_abnormal_body_composition1.14581131
56MP0003183_abnormal_peptide_metabolism1.13285275
57MP0009764_decreased_sensitivity_to1.12773820
58MP0002332_abnormal_exercise_endurance1.06406041
59MP0000858_altered_metastatic_potential1.05597156
60MP0003172_abnormal_lysosome_physiology1.04757735
61MP0008004_abnormal_stomach_pH1.04419235
62MP0004808_abnormal_hematopoietic_stem1.03422282
63MP0002139_abnormal_hepatobiliary_system1.02089138
64MP0009278_abnormal_bone_marrow0.97722988
65MP0000465_gastrointestinal_hemorrhage0.95833164
66MP0003252_abnormal_bile_duct0.93212536
67MP0002009_preneoplasia0.92406796
68MP0000343_altered_response_to0.92358694
69MP0000604_amyloidosis0.91670338
70MP0002277_abnormal_respiratory_mucosa0.91229245
71MP0003690_abnormal_glial_cell0.90225783
72MP0005058_abnormal_lysosome_morphology0.89522497
73MP0005397_hematopoietic_system_phenotyp0.88417663
74MP0001545_abnormal_hematopoietic_system0.88417663
75MP0005409_darkened_coat_color0.88054382
76MP0006054_spinal_hemorrhage0.85494865
77MP0003045_fibrosis0.83750849
78MP0003806_abnormal_nucleotide_metabolis0.81620948
79MP0004782_abnormal_surfactant_physiolog0.81324288
80MP0004883_abnormal_blood_vessel0.81310395
81MP0005164_abnormal_response_to0.80320841
82MP0009763_increased_sensitivity_to0.79579512
83MP0009840_abnormal_foam_cell0.78833819
84MP0003828_pulmonary_edema0.78162874
85MP0001879_abnormal_lymphatic_vessel0.77295151
86MP0001348_abnormal_lacrimal_gland0.76465621
87MP0000920_abnormal_myelination0.74378015
88MP0003191_abnormal_cellular_cholesterol0.72539507
89MP0000249_abnormal_blood_vessel0.70198863
90MP0003091_abnormal_cell_migration0.66854372
91MP0004043_abnormal_pH_regulation0.66602719
92MP0003453_abnormal_keratinocyte_physiol0.65952625
93MP0005535_abnormal_body_temperature0.63043650
94MP0005167_abnormal_blood-brain_barrier0.62644400
95MP0000371_diluted_coat_color0.61104682
96MP0004130_abnormal_muscle_cell0.59044947
97MP0002136_abnormal_kidney_physiology0.58670820
98MP0002132_abnormal_respiratory_system0.58650862
99MP0004185_abnormal_adipocyte_glucose0.58271319
100MP0002693_abnormal_pancreas_physiology0.56503058
101MP0002019_abnormal_tumor_incidence0.56077354
102MP0000015_abnormal_ear_pigmentation0.55864919
103MP0008874_decreased_physiological_sensi0.55660902
104MP0001986_abnormal_taste_sensitivity0.55573067
105MP0000490_abnormal_crypts_of0.54176083
106MP0005266_abnormal_metabolism0.53979814
107MP0009765_abnormal_xenobiotic_induced0.53943222
108MP0005174_abnormal_tail_pigmentation0.53396009
109MP0005023_abnormal_wound_healing0.53056597
110MP0005166_decreased_susceptibility_to0.52797531
111MP0000383_abnormal_hair_follicle0.51689483
112MP0002168_other_aberrant_phenotype0.51018331
113MP0005647_abnormal_sex_gland0.51011093
114MP0003656_abnormal_erythrocyte_physiolo0.50904815
115MP0005390_skeleton_phenotype0.50260587
116MP0003795_abnormal_bone_structure0.49790397
117MP0001216_abnormal_epidermal_layer0.49702433
118MP0001663_abnormal_digestive_system0.47763478
119MP0001191_abnormal_skin_condition0.45479489
120MP0010307_abnormal_tumor_latency0.42947445
121MP0008961_abnormal_basal_metabolism0.42816721
122MP0002163_abnormal_gland_morphology0.42156982
123MP0001881_abnormal_mammary_gland0.41226239
124MP0003075_altered_response_to0.41154710
125MP0005075_abnormal_melanosome_morpholog0.40227326
126MP0009115_abnormal_fat_cell0.37972032
127MP0000767_abnormal_smooth_muscle0.37214573

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)6.52208672
2Abnormality of T cell number (HP:0011839)6.03020834
3T lymphocytopenia (HP:0005403)6.01860068
4Elevated erythrocyte sedimentation rate (HP:0003565)5.28664395
5Nasal polyposis (HP:0100582)5.26559741
6Recurrent bronchitis (HP:0002837)5.21134266
7Recurrent fungal infections (HP:0002841)5.11755490
8Recurrent cutaneous fungal infections (HP:0011370)4.97995652
9Chronic mucocutaneous candidiasis (HP:0002728)4.97995652
10Recurrent viral infections (HP:0004429)4.95869215
11Severe combined immunodeficiency (HP:0004430)4.92739917
12Abnormality of the nasal mucosa (HP:0000433)4.90220839
13Eczematoid dermatitis (HP:0000976)4.79913242
14Panhypogammaglobulinemia (HP:0003139)4.53362339
15Myositis (HP:0100614)4.43169185
16Abnormality of T cells (HP:0002843)4.37990211
17Combined immunodeficiency (HP:0005387)4.37613922
18Stomatitis (HP:0010280)4.32668263
19Optic neuritis (HP:0100653)4.17651400
20Retrobulbar optic neuritis (HP:0100654)4.17651400
21Thyroiditis (HP:0100646)4.05026205
22Autoimmune hemolytic anemia (HP:0001890)4.04858998
23Increased IgM level (HP:0003496)3.99002358
24Abnormality of B cell number (HP:0010975)3.98340845
25B lymphocytopenia (HP:0010976)3.98340845
26Autoimmune thrombocytopenia (HP:0001973)3.98299609
27Chronic sinusitis (HP:0011109)3.95636975
28Eosinophilia (HP:0001880)3.87391174
29Orchitis (HP:0100796)3.85650301
30Recurrent abscess formation (HP:0002722)3.77949320
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.76186752
32Abnormality of eosinophils (HP:0001879)3.67736055
33Vasculitis (HP:0002633)3.59034821
34IgG deficiency (HP:0004315)3.58267094
35Mediastinal lymphadenopathy (HP:0100721)3.50500105
36Recurrent skin infections (HP:0001581)3.47669997
37Hypoplasia of the thymus (HP:0000778)3.39651863
38Leukocytosis (HP:0001974)3.33921661
39Granulocytopenia (HP:0001913)3.32883264
40Meningitis (HP:0001287)3.30132544
41Chronic diarrhea (HP:0002028)3.28531989
42Spontaneous hematomas (HP:0007420)3.25475733
43Hemoptysis (HP:0002105)3.23020713
44Recurrent bacterial skin infections (HP:0005406)3.13960273
45Pustule (HP:0200039)3.09401917
46Agammaglobulinemia (HP:0004432)3.07039100
47Prostate neoplasm (HP:0100787)3.01903250
48Chronic obstructive pulmonary disease (HP:0006510)3.01866084
49Obstructive lung disease (HP:0006536)3.01866084
50Hypergammaglobulinemia (HP:0010702)3.00971683
51Stomach cancer (HP:0012126)2.99152999
52Abnormality of the fingertips (HP:0001211)2.99022397
53Pulmonary infiltrates (HP:0002113)2.92291843
54Inflammation of the large intestine (HP:0002037)2.91678353
55Abnormality of T cell physiology (HP:0011840)2.89167152
56Increased IgE level (HP:0003212)2.88359682
57Joint swelling (HP:0001386)2.86287808
58Bronchitis (HP:0012387)2.85812413
59Systemic lupus erythematosus (HP:0002725)2.85590639
60Keratoconjunctivitis (HP:0001096)2.82519357
61Encephalitis (HP:0002383)2.81389025
62Keratoconjunctivitis sicca (HP:0001097)2.78722275
63Gastrointestinal inflammation (HP:0004386)2.73253219
64IgM deficiency (HP:0002850)2.73120363
65Abnormality of macrophages (HP:0004311)2.69845379
66Lymphopenia (HP:0001888)2.69245099
67Colitis (HP:0002583)2.66930874
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.63919670
69Arterial thrombosis (HP:0004420)2.63226527
70IgA deficiency (HP:0002720)2.61220993
71Gastrointestinal infarctions (HP:0005244)2.57810236
72Hematochezia (HP:0002573)2.52762170
73Emphysema (HP:0002097)2.52417828
74Basal ganglia calcification (HP:0002135)2.51181345
75Abnormality of the pleura (HP:0002103)2.49617064
76Genetic anticipation (HP:0003743)2.49001327
77Recurrent gram-negative bacterial infections (HP:0005420)2.47763690
78Pulmonary embolism (HP:0002204)2.46480125
79Urticaria (HP:0001025)2.41342592
80Recurrent sinusitis (HP:0011108)2.33269245
81Hypoproteinemia (HP:0003075)2.31727754
82Porencephaly (HP:0002132)2.31118992
83Cheilitis (HP:0100825)2.28640983
84Alveolar cell carcinoma (HP:0006519)2.28051025
85Increased cerebral lipofuscin (HP:0011813)2.27043663
86Vertigo (HP:0002321)2.25687111
87Lymphoma (HP:0002665)2.25314534
88Hypochromic anemia (HP:0001931)2.23442887
89Neoplasm of the tracheobronchial system (HP:0100552)2.21686394
90Gingival bleeding (HP:0000225)2.20120160
91Gingivitis (HP:0000230)2.19256560
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.19000053
93Gangrene (HP:0100758)2.16119569
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13140942
95Abnormality of glycolipid metabolism (HP:0010969)2.10056000
96Abnormality of liposaccharide metabolism (HP:0010968)2.10056000
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.10056000
98Gastrointestinal stroma tumor (HP:0100723)2.09072200
99Episodic fever (HP:0001954)2.05795753
100Bronchiectasis (HP:0002110)2.05737825
101Abnormality of the pericardium (HP:0001697)2.04089058
102Periodontitis (HP:0000704)2.01990302
103Epistaxis (HP:0000421)2.01372211
104Loss of speech (HP:0002371)2.00000017
105Keratitis (HP:0000491)1.99351423
106Malnutrition (HP:0004395)1.98967393
107Abnormality of the prostate (HP:0008775)1.98212215
108Skin ulcer (HP:0200042)1.96910325
109Chest pain (HP:0100749)1.96402374
110Cellulitis (HP:0100658)1.95790700
111Peritonitis (HP:0002586)1.94283679
112Acne (HP:0001061)1.93648831
113Interstitial pulmonary disease (HP:0006530)1.91852382
114Abnormality of the endocardium (HP:0004306)1.90150306
115Thrombocytosis (HP:0001894)1.89613092
116Aplasia/Hypoplasia of the thymus (HP:0010515)1.86701919
117Sepsis (HP:0100806)1.83620517
118Amaurosis fugax (HP:0100576)1.79813801
119Prolonged bleeding time (HP:0003010)1.78319412
120Polyneuropathy (HP:0001271)1.77955259
121Anorexia (HP:0002039)1.75820487
122Recurrent pneumonia (HP:0006532)1.75647937
123Verrucae (HP:0200043)1.74130511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.49189015
2MAP4K14.82931137
3FGFR43.87360187
4IKBKE3.76180075
5TYK23.55464091
6JAK33.49766105
7FRK3.36193022
8MAP3K143.34157240
9JAK12.75447535
10TBK12.62631554
11FGFR32.47973511
12KIT2.35429505
13ZAP702.33551800
14ITK2.20573083
15MAP3K132.05867528
16BLK1.92178002
17MATK1.82928075
18EPHB11.80541166
19IRAK41.75093606
20IKBKB1.73870140
21CSK1.73424413
22ACVR1B1.66333385
23STK101.66215272
24LCK1.65656135
25NLK1.49811865
26TEC1.48911726
27SYK1.44651200
28MST41.41905662
29PRPF4B1.38136172
30SIK21.34506906
31HCK1.33572102
32RIPK11.33058822
33EPHA31.23469136
34IRAK31.23231073
35KDR1.23222518
36TIE11.22755663
37PRKCQ1.21771947
38GRK61.19396824
39CHUK1.19136995
40BTK1.16906934
41CDK191.16003186
42TGFBR21.13902213
43MAP2K31.00876108
44PIM10.99801349
45FES0.99177960
46JAK20.95588812
47TNK20.94129305
48CDC42BPA0.87279949
49MARK30.84856441
50PRKCH0.84435547
51OXSR10.83492175
52LYN0.83339758
53PIK3CG0.81919573
54DAPK20.80075318
55IRAK10.79108337
56CLK10.77933665
57PBK0.75371358
58TAOK20.73152364
59MAPK110.72484801
60CSF1R0.71943073
61MAP3K100.71662012
62MAP3K110.69809358
63CAMKK20.66935529
64TAOK10.65566235
65MAP3K30.65266843
66BMPR1B0.64223494
67MAP3K10.63684402
68RPS6KA50.63419110
69NME20.61518574
70PKN10.61502776
71MAP2K60.60401021
72LRRK20.59588108
73STK40.59109026
74RIPK40.58704592
75RPS6KA40.57113719
76DDR20.56975696
77TLK10.54780101
78MAP3K70.52793393
79MAPK120.51423357
80FGR0.50654590
81PTK60.48402863
82PDK10.47321869
83NEK60.45722443
84EIF2AK20.44534526
85TAOK30.42090798
86EGFR0.41874874
87TTN0.41338048
88INSR0.40712156
89PIK3CA0.36948763
90ABL10.36638318
91GRK10.36486306
92MAP3K50.36474814
93PDGFRB0.36166257
94FYN0.36112175
95GRK70.35956380
96HIPK20.35358124
97SIK30.35274667
98BMPR20.34524000
99TRPM70.34389707
100MAPK70.34171182
101PDPK10.33500527
102MELK0.33258626
103IGF1R0.32543583
104FER0.32420019
105PRKAA20.32314949
106PRKD20.32235994
107ADRBK20.32164309
108PRKCD0.30148883
109ADRBK10.29304024
110MAPK30.29249845
111SGK30.28983219
112MUSK0.28004146
113PIM20.27806369
114MARK20.27787398
115MAPK40.27204863
116IRAK20.26438271
117ERN10.25106462
118PTK2B0.24955816
119STK110.24651919
120RPS6KA60.23815364
121TYRO30.23814394
122GRK50.23780241
123YES10.23575246
124SGK20.22641617
125BMX0.21812672
126SRC0.21498616
127TGFBR10.21236858
128MAPKAPK20.19609862
129PRKG20.19391084
130PRKD10.19190151
131CDK40.18552919
132CDK120.17423950
133NUAK10.17402807
134PKN20.16116035
135CDK60.15933405

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.97953155
2Allograft rejection_Homo sapiens_hsa053303.35548617
3Graft-versus-host disease_Homo sapiens_hsa053323.01954662
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.00344254
5Measles_Homo sapiens_hsa051622.99740944
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.98398589
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.97016970
8T cell receptor signaling pathway_Homo sapiens_hsa046602.78437855
9Autoimmune thyroid disease_Homo sapiens_hsa053202.48907340
10Antigen processing and presentation_Homo sapiens_hsa046122.46821233
11Leishmaniasis_Homo sapiens_hsa051402.44851163
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.35396981
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29635927
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.28927557
15Osteoclast differentiation_Homo sapiens_hsa043802.18826321
16Jak-STAT signaling pathway_Homo sapiens_hsa046302.05803390
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98308927
18Hematopoietic cell lineage_Homo sapiens_hsa046401.94597724
19Herpes simplex infection_Homo sapiens_hsa051681.89229224
20Viral myocarditis_Homo sapiens_hsa054161.76428045
21Toxoplasmosis_Homo sapiens_hsa051451.69048846
22B cell receptor signaling pathway_Homo sapiens_hsa046621.67891925
23Influenza A_Homo sapiens_hsa051641.66389961
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59787636
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59321220
26Staphylococcus aureus infection_Homo sapiens_hsa051501.58421448
27Malaria_Homo sapiens_hsa051441.56310161
28Chemokine signaling pathway_Homo sapiens_hsa040621.53651316
29TNF signaling pathway_Homo sapiens_hsa046681.50204622
30Asthma_Homo sapiens_hsa053101.49825789
31Type I diabetes mellitus_Homo sapiens_hsa049401.49729926
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38042029
33Hepatitis C_Homo sapiens_hsa051601.29743918
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24758802
35Pertussis_Homo sapiens_hsa051331.24401830
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.21300426
37Rheumatoid arthritis_Homo sapiens_hsa053231.20775074
38Tuberculosis_Homo sapiens_hsa051521.19701467
39Hepatitis B_Homo sapiens_hsa051611.18779887
40African trypanosomiasis_Homo sapiens_hsa051431.16653724
41Apoptosis_Homo sapiens_hsa042101.16203234
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13085291
43Prolactin signaling pathway_Homo sapiens_hsa049170.99702859
44Tryptophan metabolism_Homo sapiens_hsa003800.96457410
45Acute myeloid leukemia_Homo sapiens_hsa052210.96369571
46Shigellosis_Homo sapiens_hsa051310.92863709
47Legionellosis_Homo sapiens_hsa051340.91670185
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90794550
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83780479
50Salmonella infection_Homo sapiens_hsa051320.83490107
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80510156
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78277597
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77145799
54Platelet activation_Homo sapiens_hsa046110.74040497
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.72527407
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70456947
57Non-homologous end-joining_Homo sapiens_hsa034500.70418802
58Linoleic acid metabolism_Homo sapiens_hsa005910.69679925
59Pancreatic cancer_Homo sapiens_hsa052120.68922088
60HTLV-I infection_Homo sapiens_hsa051660.67758310
61Small cell lung cancer_Homo sapiens_hsa052220.64196133
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61648229
63Epstein-Barr virus infection_Homo sapiens_hsa051690.61544091
64ABC transporters_Homo sapiens_hsa020100.60200663
65Viral carcinogenesis_Homo sapiens_hsa052030.58542539
66Caffeine metabolism_Homo sapiens_hsa002320.58015704
67Chronic myeloid leukemia_Homo sapiens_hsa052200.50942384
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49558718
69Ether lipid metabolism_Homo sapiens_hsa005650.48313716
70HIF-1 signaling pathway_Homo sapiens_hsa040660.45340133
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.44038596
72Notch signaling pathway_Homo sapiens_hsa043300.43948457
73Complement and coagulation cascades_Homo sapiens_hsa046100.41027143
74Arachidonic acid metabolism_Homo sapiens_hsa005900.40547843
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40396085
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39722546
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38468998
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37579309
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35950001
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.35850136
81VEGF signaling pathway_Homo sapiens_hsa043700.35831069
82Systemic lupus erythematosus_Homo sapiens_hsa053220.35787044
83Lysosome_Homo sapiens_hsa041420.35783674
84Phagosome_Homo sapiens_hsa041450.33183387
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.32940544
86Amoebiasis_Homo sapiens_hsa051460.32076708
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31550176
88Dorso-ventral axis formation_Homo sapiens_hsa043200.31356207
89Endocytosis_Homo sapiens_hsa041440.30121335
90MAPK signaling pathway_Homo sapiens_hsa040100.29572335
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28706277
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27220810
93Glycerolipid metabolism_Homo sapiens_hsa005610.26375063
94Colorectal cancer_Homo sapiens_hsa052100.25404424
95FoxO signaling pathway_Homo sapiens_hsa040680.25072907
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.24781373
97Pathways in cancer_Homo sapiens_hsa052000.24630229
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.24629593
99Insulin resistance_Homo sapiens_hsa049310.24465097
100Rap1 signaling pathway_Homo sapiens_hsa040150.23882560
101Prostate cancer_Homo sapiens_hsa052150.23167269
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22966979
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22645892
104MicroRNAs in cancer_Homo sapiens_hsa052060.21769148
105Ras signaling pathway_Homo sapiens_hsa040140.20959950
106Renin-angiotensin system_Homo sapiens_hsa046140.19734174
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19639245
108Other glycan degradation_Homo sapiens_hsa005110.19216979
109Type II diabetes mellitus_Homo sapiens_hsa049300.18883883
110Inositol phosphate metabolism_Homo sapiens_hsa005620.16310114
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.16040739
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15992165
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.15274557
114Regulation of autophagy_Homo sapiens_hsa041400.14837884
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14603803
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14528424
117Renal cell carcinoma_Homo sapiens_hsa052110.14420605
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.13407771
119p53 signaling pathway_Homo sapiens_hsa041150.11610979
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11564578
121Focal adhesion_Homo sapiens_hsa045100.09676744
122Choline metabolism in cancer_Homo sapiens_hsa052310.09006837
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08021289

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