GBP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.25153045
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.25153045
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.25153045
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.25153045
5modulation by symbiont of host immune response (GO:0052553)6.25153045
6positive regulation by symbiont of host defense response (GO:0052509)6.25153045
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.03485209
8negative regulation of cell killing (GO:0031342)6.03485209
9cellular response to type I interferon (GO:0071357)5.84304777
10type I interferon signaling pathway (GO:0060337)5.84304777
11response to type I interferon (GO:0034340)5.79997178
12positive regulation of interferon-alpha production (GO:0032727)5.65919917
13regulation of interferon-alpha production (GO:0032647)5.37660116
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.28835310
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.28835310
16response to interferon-alpha (GO:0035455)5.14618360
17response to peptidoglycan (GO:0032494)5.03349303
18antigen processing and presentation of endogenous antigen (GO:0019883)4.98228305
19regulation of B cell receptor signaling pathway (GO:0050855)4.85830227
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.85801203
21response to host immune response (GO:0052572)4.85801203
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.74891319
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.59173788
24positive regulation of gamma-delta T cell activation (GO:0046645)4.59080300
25negative regulation of viral genome replication (GO:0045071)4.57815185
26regulation of T cell tolerance induction (GO:0002664)4.48713566
27macrophage activation involved in immune response (GO:0002281)4.37967187
28regulation of T-helper 1 cell differentiation (GO:0045625)4.35823860
29NIK/NF-kappaB signaling (GO:0038061)4.33574339
30response to host (GO:0075136)4.30971604
31response to host defenses (GO:0052200)4.30971604
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.30971604
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.30317084
34positive regulation of type 2 immune response (GO:0002830)4.29833821
35positive regulation of interferon-beta production (GO:0032728)4.24554311
36regulation of dendritic cell antigen processing and presentation (GO:0002604)4.24345404
37regulation of RIG-I signaling pathway (GO:0039535)4.19993464
38regulation of tolerance induction (GO:0002643)4.19961617
39cellular response to interferon-beta (GO:0035458)4.19708198
40response to muramyl dipeptide (GO:0032495)4.17992218
41interferon-gamma-mediated signaling pathway (GO:0060333)4.17298934
42positive regulation of T cell cytokine production (GO:0002726)4.13763843
43regulation of regulatory T cell differentiation (GO:0045589)4.13095572
44regulation of interferon-beta biosynthetic process (GO:0045357)4.11446975
45positive regulation of tolerance induction (GO:0002645)4.09983101
46cellular response to virus (GO:0098586)4.08555746
47neutrophil activation involved in immune response (GO:0002283)4.06477945
48positive regulation of interleukin-12 production (GO:0032735)4.04662341
49positive regulation of antigen processing and presentation (GO:0002579)4.03503269
50positive regulation of natural killer cell differentiation (GO:0032825)4.00932329
51natural killer cell mediated immunity (GO:0002228)4.00498190
52natural killer cell mediated cytotoxicity (GO:0042267)4.00498190
53negative regulation of T cell mediated immunity (GO:0002710)4.00248864
54negative T cell selection (GO:0043383)3.99437188
55negative thymic T cell selection (GO:0045060)3.98270525
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.94954872
57cellular response to interferon-alpha (GO:0035457)3.92034660
58detection of other organism (GO:0098543)3.91345068
59regulation of gamma-delta T cell differentiation (GO:0045586)3.90850944
60regulation of interleukin-12 biosynthetic process (GO:0045075)3.87418595
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.87156853
62positive regulation of cellular amide metabolic process (GO:0034250)3.85791793
63cellular response to exogenous dsRNA (GO:0071360)3.83633406
64response to interleukin-15 (GO:0070672)3.82583886
65lipopolysaccharide-mediated signaling pathway (GO:0031663)3.76797223
66T cell migration (GO:0072678)3.75754477
67positive regulation of interleukin-17 production (GO:0032740)3.73933056
68production of molecular mediator involved in inflammatory response (GO:0002532)3.72498064
69detection of external biotic stimulus (GO:0098581)3.69531325
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.63576089
71immunoglobulin mediated immune response (GO:0016064)3.62683851
72I-kappaB phosphorylation (GO:0007252)3.61287725
73microglial cell activation (GO:0001774)3.61099227
74positive regulation of toll-like receptor signaling pathway (GO:0034123)3.57301181
75defense response to virus (GO:0051607)3.53522793
76positive regulation of humoral immune response (GO:0002922)3.53004693
77leukocyte aggregation (GO:0070486)3.51066501
78detection of bacterium (GO:0016045)3.50434385
79cellular response to interleukin-15 (GO:0071350)3.50310720
80regulation of type I interferon-mediated signaling pathway (GO:0060338)3.50162639
81T-helper 1 type immune response (GO:0042088)3.48224133
82positive regulation of chemokine biosynthetic process (GO:0045080)3.47797413
83regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.46583176
84cellular response to interferon-gamma (GO:0071346)3.45328280
85granulocyte activation (GO:0036230)3.45161356
86regulation of antigen processing and presentation (GO:0002577)3.43685738
87interferon-gamma production (GO:0032609)3.42837643
88response to interferon-beta (GO:0035456)3.42773377
89antigen processing and presentation via MHC class Ib (GO:0002475)3.39417493
90positive regulation of heat generation (GO:0031652)3.38978057
91regulation of interleukin-17 production (GO:0032660)3.37698798
92negative regulation of leukocyte mediated immunity (GO:0002704)3.37426441
93myeloid dendritic cell differentiation (GO:0043011)3.35638423
94regulation of T cell cytokine production (GO:0002724)3.32122830
95regulation of T cell mediated cytotoxicity (GO:0001914)3.31820316
96regulation of interleukin-12 production (GO:0032655)3.30737915
97positive thymic T cell selection (GO:0045059)3.29717552
98neutrophil activation (GO:0042119)3.29624706
99tolerance induction (GO:0002507)3.29461537
100detection of biotic stimulus (GO:0009595)3.29232609
101defense response to protozoan (GO:0042832)3.28444710
102macrophage activation (GO:0042116)3.26580879
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.25630911
104regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25533283
105detection of molecule of bacterial origin (GO:0032490)3.22366298
106regulation of activation of Janus kinase activity (GO:0010533)3.20912111
107positive regulation of response to biotic stimulus (GO:0002833)3.18652571
108positive T cell selection (GO:0043368)3.17678862
109positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16196909
110regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.15629060
111positive regulation of interleukin-1 beta secretion (GO:0050718)3.15173319
112regulation of alpha-beta T cell proliferation (GO:0046640)3.13785475
113negative regulation of interleukin-17 production (GO:0032700)3.12841388
114modulation by symbiont of host cellular process (GO:0044068)3.12517859
115positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11347014
116regulation of interferon-beta production (GO:0032648)3.10423812
117regulation of fever generation (GO:0031620)3.09383403
118positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.07912487
119interferon-gamma secretion (GO:0072643)3.07849352
120positive regulation of defense response to virus by host (GO:0002230)3.07481072
121regulation of interleukin-1 beta secretion (GO:0050706)3.06602029
122lymphocyte chemotaxis (GO:0048247)3.06350725
123myeloid cell activation involved in immune response (GO:0002275)3.05790929
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05292451
125activated T cell proliferation (GO:0050798)3.05219155
126regulation of immunoglobulin secretion (GO:0051023)3.04664450
127negative regulation of interleukin-12 production (GO:0032695)3.04551134
128myeloid dendritic cell activation (GO:0001773)3.04302508
129regulation of interferon-gamma biosynthetic process (GO:0045072)3.03536060
130regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03355307
131B cell mediated immunity (GO:0019724)3.03034958
132negative regulation of innate immune response (GO:0045824)3.02948908
133positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.02812171
134regulation of gamma-delta T cell activation (GO:0046643)3.02671114
135cellular extravasation (GO:0045123)3.02569089
136positive regulation of interleukin-10 production (GO:0032733)3.02537651
137regulation of defense response to virus by host (GO:0050691)3.02420907
138regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.02341318
139regulation of natural killer cell mediated immunity (GO:0002715)3.02341318
140T cell selection (GO:0045058)3.01763707
141superoxide anion generation (GO:0042554)3.01441288
142response to protozoan (GO:0001562)3.01137826
143response to interferon-gamma (GO:0034341)2.99983116
144B cell receptor signaling pathway (GO:0050853)2.98397050
145myeloid leukocyte mediated immunity (GO:0002444)2.95773050
146positive regulation of interleukin-1 secretion (GO:0050716)2.95381459
147JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.93903225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.56688051
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.36279556
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.16318785
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.25491149
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.65998555
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.27134386
7* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.76759485
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56123271
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38727691
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20710389
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17696431
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00443760
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94445682
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.81548130
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57018741
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33973322
17GATA1_22025678_ChIP-Seq_K562_Human2.28279597
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27631994
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00946781
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84638382
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83850351
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.82103200
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78792849
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.73716799
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71757970
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60459267
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55610930
28MYB_26560356_Chip-Seq_TH2_Human1.51887957
29SPI1_23547873_ChIP-Seq_NB4_Human1.47828364
30PU_27001747_Chip-Seq_BMDM_Mouse1.47346306
31* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44820853
32SPI1_23127762_ChIP-Seq_K562_Human1.42385236
33VDR_24787735_ChIP-Seq_THP-1_Human1.42161760
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41770372
35SCL_19346495_ChIP-Seq_HPC-7_Human1.38582332
36* RUNX_20019798_ChIP-Seq_JUKART_Human1.38343113
37* MAF_26560356_Chip-Seq_TH1_Human1.36967645
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34036791
39* MYB_26560356_Chip-Seq_TH1_Human1.29645882
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.27957035
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24707512
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.22453056
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22335715
44GATA3_26560356_Chip-Seq_TH2_Human1.14196436
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11962922
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11521908
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10637152
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10233692
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09380138
50TCF7_22412390_ChIP-Seq_EML_Mouse1.09337541
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09137605
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07753215
53MYC_22102868_ChIP-Seq_BL_Human1.07689076
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06724822
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.06307360
56VDR_24763502_ChIP-Seq_THP-1_Human1.05525643
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.05518473
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02022617
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99222534
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99218485
61GATA3_27048872_Chip-Seq_THYMUS_Human0.98320858
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95711274
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92031245
64GATA1_19941826_ChIP-Seq_K562_Human0.91954030
65KDM2B_26808549_Chip-Seq_DND41_Human0.91336306
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91310524
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89922395
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89400460
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89201620
70CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89016463
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84138007
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84099565
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84093000
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83659407
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80992156
76GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80507715
77GATA2_19941826_ChIP-Seq_K562_Human0.80442944
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80335003
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80330033
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78320080
81EGR1_19032775_ChIP-ChIP_M12_Human0.75715939
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74968258
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.74762987
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74745340
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74740734
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73758158
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72990813
88UTX_26944678_Chip-Seq_JUKART_Human0.70407849
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70129041
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69869905
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69603615
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69073371
93GATA3_26560356_Chip-Seq_TH1_Human0.68328324
94PU1_27457419_Chip-Seq_LIVER_Mouse0.68325871
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68280662
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67973226
97* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65789842
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64561827
99VDR_21846776_ChIP-Seq_THP-1_Human0.63836597
100SMRT_27268052_Chip-Seq_Bcells_Human0.63678561
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.63348809
102NMYC_18555785_Chip-Seq_ESCs_Mouse0.63128438
103* STAT3_18555785_Chip-Seq_ESCs_Mouse0.63024509
104* MAF_26560356_Chip-Seq_TH2_Human0.62954419
105SOX2_20726797_ChIP-Seq_SW620_Human0.62674304
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.62610626
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62149078
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.60971637
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60963474
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60095610
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.59492067
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.58701324
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.58581922
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.58471303
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57649945
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57649945
117* CMYC_18555785_Chip-Seq_ESCs_Mouse0.57617955
118* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.57592852
119STAT1_20625510_ChIP-Seq_HELA_Human0.57545431
120CTCF_18555785_Chip-Seq_ESCs_Mouse0.57081006
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56267147
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.56013613
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.55808974
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.55777605
125SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55759662
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.54810968
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54810968
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.54394131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.78961153
2MP0009785_altered_susceptibility_to4.45757136
3MP0001790_abnormal_immune_system3.60957704
4MP0005387_immune_system_phenotype3.60957704
5MP0000685_abnormal_immune_system3.55063130
6MP0002148_abnormal_hypersensitivity_rea3.42637957
7MP0003436_decreased_susceptibility_to3.42137567
8MP0004510_myositis3.39208067
9MP0006082_CNS_inflammation3.36043664
10MP0005025_abnormal_response_to3.21042899
11MP0005000_abnormal_immune_tolerance3.19373602
12MP0003303_peritoneal_inflammation3.18618826
13MP0002419_abnormal_innate_immunity2.91240352
14MP0005671_abnormal_response_to2.88925374
15MP0003724_increased_susceptibility_to2.87317750
16MP0001800_abnormal_humoral_immune2.85551082
17MP0002452_abnormal_antigen_presenting2.75290467
18MP0002723_abnormal_immune_serum2.71736230
19MP0001819_abnormal_immune_cell2.32127469
20MP0002420_abnormal_adaptive_immunity2.24479200
21MP0004947_skin_inflammation2.20600644
22MP0000569_abnormal_digit_pigmentation2.10353798
23MP0009764_decreased_sensitivity_to2.10170271
24MP0005058_abnormal_lysosome_morphology2.08144764
25MP0001533_abnormal_skeleton_physiology1.88843904
26MP0010155_abnormal_intestine_physiology1.86505351
27MP0001853_heart_inflammation1.86412720
28MP0002006_tumorigenesis1.85096511
29MP0003172_abnormal_lysosome_physiology1.83652201
30MP0003448_altered_tumor_morphology1.82148963
31MP0001845_abnormal_inflammatory_respons1.78932754
32MP0005464_abnormal_platelet_physiology1.75175381
33MP0005451_abnormal_body_composition1.73713600
34MP0008469_abnormal_protein_level1.73385002
35MP0005310_abnormal_salivary_gland1.71446875
36MP0002405_respiratory_system_inflammati1.71364231
37MP0000716_abnormal_immune_system1.70990465
38MP0008260_abnormal_autophagy1.65645541
39MP0002398_abnormal_bone_marrow1.64938436
40MP0009278_abnormal_bone_marrow1.64852978
41MP0002254_reproductive_system_inflammat1.64818956
42MP0002166_altered_tumor_susceptibility1.52481506
43MP0004858_abnormal_nervous_system1.43352851
44MP0000343_altered_response_to1.40769282
45MP0002998_abnormal_bone_remodeling1.40533247
46MP0002277_abnormal_respiratory_mucosa1.39642225
47MP0003075_altered_response_to1.37541394
48MP0000604_amyloidosis1.32661765
49MP0002429_abnormal_blood_cell1.31874933
50MP0001545_abnormal_hematopoietic_system1.31427281
51MP0005397_hematopoietic_system_phenotyp1.31427281
52MP0004883_abnormal_blood_vessel1.30361568
53MP0002138_abnormal_hepatobiliary_system1.29436237
54MP0004381_abnormal_hair_follicle1.25742757
55MP0000689_abnormal_spleen_morphology1.22891786
56MP0009333_abnormal_splenocyte_physiolog1.19769525
57MP0010307_abnormal_tumor_latency1.18301380
58MP0003300_gastrointestinal_ulcer1.17454654
59MP0004782_abnormal_surfactant_physiolog1.15005072
60MP0002722_abnormal_immune_system1.14082947
61MP0003183_abnormal_peptide_metabolism1.12258233
62MP0000465_gastrointestinal_hemorrhage1.12201051
63MP0003763_abnormal_thymus_physiology1.11732878
64MP0009763_increased_sensitivity_to1.10216151
65MP0002132_abnormal_respiratory_system1.08912527
66MP0009840_abnormal_foam_cell1.08400387
67MP0003656_abnormal_erythrocyte_physiolo1.05704504
68MP0003191_abnormal_cellular_cholesterol1.02768569
69MP0003091_abnormal_cell_migration1.01975817
70MP0003221_abnormal_cardiomyocyte_apopto1.00915562
71MP0000858_altered_metastatic_potential1.00759624
72MP0003045_fibrosis0.95581941
73MP0005166_decreased_susceptibility_to0.93765094
74MP0003787_abnormal_imprinting0.93349858
75MP0005390_skeleton_phenotype0.86903728
76MP0004808_abnormal_hematopoietic_stem0.84351264
77MP0005164_abnormal_response_to0.84225945
78MP0003453_abnormal_keratinocyte_physiol0.83975382
79MP0003690_abnormal_glial_cell0.83837063
80MP0005075_abnormal_melanosome_morpholog0.82913186
81MP0000371_diluted_coat_color0.82535182
82MP0001873_stomach_inflammation0.82413367
83MP0005174_abnormal_tail_pigmentation0.79059506
84MP0001663_abnormal_digestive_system0.78653430
85MP0002332_abnormal_exercise_endurance0.77893098
86MP0005167_abnormal_blood-brain_barrier0.77590494
87MP0003195_calcinosis0.75917323
88MP0002163_abnormal_gland_morphology0.74324629
89MP0005076_abnormal_cell_differentiation0.71172803
90MP0005257_abnormal_intraocular_pressure0.70468484
91MP0002933_joint_inflammation0.69114412
92MP0001501_abnormal_sleep_pattern0.68827184
93MP0000703_abnormal_thymus_morphology0.68023220
94MP0003828_pulmonary_edema0.67105746
95MP0003646_muscle_fatigue0.66478199
96MP0009765_abnormal_xenobiotic_induced0.65729149
97MP0001348_abnormal_lacrimal_gland0.65118767
98MP0000249_abnormal_blood_vessel0.63937453
99MP0003806_abnormal_nucleotide_metabolis0.61583021
100MP0000015_abnormal_ear_pigmentation0.60143185
101MP0001851_eye_inflammation0.59589972
102MP0000767_abnormal_smooth_muscle0.59432380
103MP0000490_abnormal_crypts_of0.58832046
104MP0006054_spinal_hemorrhage0.57720810
105MP0008874_decreased_physiological_sensi0.57474503
106MP0001881_abnormal_mammary_gland0.57144966
107MP0008873_increased_physiological_sensi0.55890644
108MP0002136_abnormal_kidney_physiology0.55825196
109MP0002019_abnormal_tumor_incidence0.54887681
110MP0002693_abnormal_pancreas_physiology0.54263085
111MP0003566_abnormal_cell_adhesion0.53068657
112MP0002396_abnormal_hematopoietic_system0.51190602
113MP0010352_gastrointestinal_tract_polyps0.49999317
114MP0005319_abnormal_enzyme/_coenzyme0.49954084
115MP0008004_abnormal_stomach_pH0.49768169
116MP0000383_abnormal_hair_follicle0.49535981
117MP0001346_abnormal_lacrimal_gland0.48233610
118MP0003795_abnormal_bone_structure0.47836501
119MP0003866_abnormal_defecation0.47082242
120MP0003186_abnormal_redox_activity0.46954705

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.04479552
2Eczematoid dermatitis (HP:0000976)6.03453843
3Recurrent bacterial skin infections (HP:0005406)5.75888391
4Retrobulbar optic neuritis (HP:0100654)5.23951333
5Optic neuritis (HP:0100653)5.23951333
6Orchitis (HP:0100796)5.15683375
7Chronic otitis media (HP:0000389)4.99778279
8Myositis (HP:0100614)4.96783216
9Mediastinal lymphadenopathy (HP:0100721)4.94987110
10Elevated erythrocyte sedimentation rate (HP:0003565)4.93824394
11Abnormality of macrophages (HP:0004311)4.72066104
12Autoimmune thrombocytopenia (HP:0001973)4.71052524
13Recurrent gram-negative bacterial infections (HP:0005420)4.70305269
14Increased IgM level (HP:0003496)4.55280614
15Recurrent fungal infections (HP:0002841)4.29510926
16Recurrent viral infections (HP:0004429)4.28301982
17Vasculitis (HP:0002633)4.22537908
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.15055389
19Basal ganglia calcification (HP:0002135)4.00291800
20Recurrent skin infections (HP:0001581)3.94612895
21Stomatitis (HP:0010280)3.90214048
22Gingivitis (HP:0000230)3.77741353
23Nasal polyposis (HP:0100582)3.64879362
24Recurrent cutaneous fungal infections (HP:0011370)3.60489871
25Chronic mucocutaneous candidiasis (HP:0002728)3.60489871
26Porencephaly (HP:0002132)3.57213247
27Pulmonary infiltrates (HP:0002113)3.54816130
28Prostate neoplasm (HP:0100787)3.48658974
29Hypergammaglobulinemia (HP:0010702)3.38769348
30Peritonitis (HP:0002586)3.33079689
31Premature loss of primary teeth (HP:0006323)3.27503843
32Periodontitis (HP:0000704)3.22138401
33Abnormality of the nasal mucosa (HP:0000433)3.17352394
34Tetraparesis (HP:0002273)3.04993026
35Arterial thrombosis (HP:0004420)3.03435558
36Chronic obstructive pulmonary disease (HP:0006510)3.00320175
37Obstructive lung disease (HP:0006536)3.00320175
38Increased cerebral lipofuscin (HP:0011813)2.99160311
39Recurrent bronchitis (HP:0002837)2.98134461
40Systemic lupus erythematosus (HP:0002725)2.95821113
41Keratoconjunctivitis sicca (HP:0001097)2.93883136
42Vacuolated lymphocytes (HP:0001922)2.92013980
43Spontaneous hematomas (HP:0007420)2.85806590
44Hemoptysis (HP:0002105)2.85751144
45Pulmonary embolism (HP:0002204)2.85190693
46Chronic sinusitis (HP:0011109)2.84524396
47Thick nail (HP:0001805)2.81348334
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.78774856
49Pustule (HP:0200039)2.77711336
50Keratoconjunctivitis (HP:0001096)2.72602368
51Gastrointestinal infarctions (HP:0005244)2.64231452
52Gingival bleeding (HP:0000225)2.63820119
53Meningitis (HP:0001287)2.63699146
54IgG deficiency (HP:0004315)2.63308171
55Acute hepatic failure (HP:0006554)2.62745667
56Leukocytosis (HP:0001974)2.58146008
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.55865215
58Interstitial pulmonary disease (HP:0006530)2.52331259
59Cellulitis (HP:0100658)2.47091117
60Cleft eyelid (HP:0000625)2.46623080
61Osteomyelitis (HP:0002754)2.46056145
62Joint swelling (HP:0001386)2.42503194
63Recurrent pneumonia (HP:0006532)2.39619130
64Myocardial infarction (HP:0001658)2.39241498
65Anorexia (HP:0002039)2.39121474
66Eosinophilia (HP:0001880)2.39061528
67Plagiocephaly (HP:0001357)2.38369635
68Increased IgE level (HP:0003212)2.37004234
69Episodic fever (HP:0001954)2.34222069
70Keratitis (HP:0000491)2.33906316
71Epistaxis (HP:0000421)2.32864831
72Glomerulopathy (HP:0100820)2.31458026
73Abnormality of the peritoneum (HP:0002585)2.29933678
74Abnormality of T cell number (HP:0011839)2.29406387
75Colitis (HP:0002583)2.28893199
76Slow saccadic eye movements (HP:0000514)2.24932478
77Urticaria (HP:0001025)2.23555504
78Recurrent lower respiratory tract infections (HP:0002783)2.23322625
79Cheilitis (HP:0100825)2.22820599
80Autoimmune hemolytic anemia (HP:0001890)2.22645990
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.22315933
82Amaurosis fugax (HP:0100576)2.22288066
83Loss of speech (HP:0002371)2.22265840
84Emphysema (HP:0002097)2.21732793
85Abnormality of B cell number (HP:0010975)2.20244423
86Severe combined immunodeficiency (HP:0004430)2.18831984
87Bone pain (HP:0002653)2.18626693
88Hematochezia (HP:0002573)2.18030490
89Polyneuropathy (HP:0001271)2.15659530
90Agammaglobulinemia (HP:0004432)2.15024041
91Lymphopenia (HP:0001888)2.14836575
92Vertigo (HP:0002321)2.14119157
93Abnormality of the prostate (HP:0008775)2.12629665
94Hypochromic anemia (HP:0001931)2.12374143
95Abnormality of the pericardium (HP:0001697)2.09870853
96Neoplasm of the tracheobronchial system (HP:0100552)2.08446512
97Prolonged bleeding time (HP:0003010)2.07935797
98Thrombophlebitis (HP:0004418)2.07760506
99IgA deficiency (HP:0002720)2.06159113
100Encephalitis (HP:0002383)2.05850786
101Panhypogammaglobulinemia (HP:0003139)2.05611984
102Amyloidosis (HP:0011034)2.04404921
103Inflammation of the large intestine (HP:0002037)2.03957206
104Alveolar cell carcinoma (HP:0006519)2.03250679
105Chronic diarrhea (HP:0002028)2.02569168
106Abnormality of glycolipid metabolism (HP:0010969)2.02284379
107Abnormality of liposaccharide metabolism (HP:0010968)2.02284379
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.02284379
109Arthralgia (HP:0002829)2.01049706
110Gangrene (HP:0100758)2.00555329
111Abnormality of the pleura (HP:0002103)1.99853883
112Abnormality of the endocardium (HP:0004306)1.98159925
113Axonal loss (HP:0003447)1.97195459
114Abnormality of T cells (HP:0002843)1.96467540
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96213368
116Abnormality of T cell physiology (HP:0011840)1.94839148
117Chest pain (HP:0100749)1.93686383
118Acne (HP:0001061)1.92620496
119T lymphocytopenia (HP:0005403)1.92579400
120Skin ulcer (HP:0200042)1.92492365
121Viral hepatitis (HP:0006562)1.91536160
122Skin rash (HP:0000988)1.91345784
123Granulocytopenia (HP:0001913)1.90756807
124Spastic tetraparesis (HP:0001285)1.89023500
125Subacute progressive viral hepatitis (HP:0006572)1.87835874
126Thyroiditis (HP:0100646)1.87134178
127Abnormality of eosinophils (HP:0001879)1.86670383
128Frequent falls (HP:0002359)1.85010730
129Gastrointestinal inflammation (HP:0004386)1.85006313
130Stomach cancer (HP:0012126)1.83712263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.91107798
2TYK24.67702514
3IKBKE4.00809532
4TBK13.76795396
5JAK33.39062004
6IRAK33.38977917
7JAK13.37092297
8IRAK43.05233592
9RIPK43.03757308
10MAP3K132.98020931
11BLK2.80291744
12IKBKB2.61616187
13TXK2.51225421
14KIT2.45187403
15PBK2.33593447
16MAP4K12.27069554
17FGFR42.22296932
18MAP2K31.87101331
19GRK61.83165806
20CHUK1.82704544
21EIF2AK21.64908643
22FGFR31.55466233
23ERN11.54496147
24PIM21.50454315
25CSK1.41251108
26EPHB11.38797451
27IRAK11.31292514
28EPHA31.30790685
29SYK1.26589078
30HCK1.22027333
31CDK121.18571848
32SIK31.18205354
33ZAP701.17216403
34TNK21.16568709
35FGR1.14893295
36LCK1.06990103
37CSF1R1.03842707
38JAK21.03221364
39MAP3K31.02081967
40BMPR20.94274746
41MARK30.93867018
42SIK20.92943361
43RPS6KA40.90201787
44PIM10.90003486
45IRAK20.89436004
46TAOK30.89262769
47MAP3K50.87321545
48LYN0.86007980
49TAOK10.84417822
50MAP3K110.83361181
51STK40.82226478
52MATK0.81322178
53LRRK20.79873971
54BMX0.79007430
55PIK3CG0.76216497
56FES0.75790683
57CDC42BPA0.73311175
58BTK0.68508164
59MST40.65485071
60TAOK20.63867270
61NEK90.61948815
62CLK10.59729277
63EGFR0.59411821
64PTK2B0.58853059
65CAMKK20.58624629
66YES10.58251071
67TEC0.58124110
68PKN10.57658391
69SGK20.56109600
70KSR20.56046814
71MAP3K100.55285818
72MAP3K20.54751162
73ABL10.52868196
74ADRBK20.52292682
75STK30.52031144
76PRKCQ0.51275829
77MARK20.49650216
78CAMK1D0.49501276
79NLK0.49029933
80PRKCD0.46950911
81SIK10.45745569
82GRK50.45696610
83MAP2K60.45560976
84DAPK20.45544484
85CDK40.45307404
86WNK10.44762970
87STK100.39318443
88TESK20.38187580
89MAP3K60.37662855
90TYRO30.37342793
91TRPM70.37326464
92TGFBR20.37289799
93KSR10.37212563
94ACVR1B0.35849637
95ITK0.34954513
96GRK70.34480444
97PTK60.34008648
98SGK10.33734929
99FRK0.33289612
100RPS6KA50.33159269
101TTN0.31572283
102DAPK30.31360816
103RIPK10.29911617
104MST1R0.29754191
105RAF10.29747242
106RET0.28488176
107MAPK70.27784042
108ERBB20.27563044
109NME20.27312020
110NUAK10.26677226
111SGK30.25703854
112PDGFRB0.25682976
113INSRR0.25290666
114MAP3K70.24999515
115STK110.24968748
116PRKAA20.24934536
117TNIK0.24088720
118CDK60.23935371
119ABL20.23143926
120MAPK110.22719095
121INSR0.20210206
122MAPKAPK20.19897278
123PRPF4B0.19371658
124FYN0.18981659
125IGF1R0.17984836
126ARAF0.17440409
127PDK10.15401622
128MOS0.14714983
129SRC0.13538822
130HIPK20.13500841
131MAP3K10.13297665
132CAMK1G0.13119977
133PRKG20.11914046
134PDPK10.11759385

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.17142285
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.10314515
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.09306036
4Leishmaniasis_Homo sapiens_hsa051403.05912567
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.05012670
6NF-kappa B signaling pathway_Homo sapiens_hsa040643.04486584
7Graft-versus-host disease_Homo sapiens_hsa053323.01999973
8Measles_Homo sapiens_hsa051622.80630779
9Influenza A_Homo sapiens_hsa051642.53166887
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.47836456
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.38368615
12TNF signaling pathway_Homo sapiens_hsa046682.23599372
13Osteoclast differentiation_Homo sapiens_hsa043802.18642706
14Herpes simplex infection_Homo sapiens_hsa051682.16754435
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16137426
16Staphylococcus aureus infection_Homo sapiens_hsa051502.15535432
17Malaria_Homo sapiens_hsa051442.10068174
18Pertussis_Homo sapiens_hsa051332.01146120
19Legionellosis_Homo sapiens_hsa051341.98893589
20Tuberculosis_Homo sapiens_hsa051521.95917462
21Asthma_Homo sapiens_hsa053101.93171155
22Type I diabetes mellitus_Homo sapiens_hsa049401.91240506
23Rheumatoid arthritis_Homo sapiens_hsa053231.90209424
24Autoimmune thyroid disease_Homo sapiens_hsa053201.76911295
25African trypanosomiasis_Homo sapiens_hsa051431.74570237
26Toxoplasmosis_Homo sapiens_hsa051451.69940646
27Primary immunodeficiency_Homo sapiens_hsa053401.64665868
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.59185460
29Hepatitis C_Homo sapiens_hsa051601.58573683
30B cell receptor signaling pathway_Homo sapiens_hsa046621.45081464
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43769254
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39525371
33Chemokine signaling pathway_Homo sapiens_hsa040621.39524848
34Apoptosis_Homo sapiens_hsa042101.36860881
35Hepatitis B_Homo sapiens_hsa051611.29678200
36Hematopoietic cell lineage_Homo sapiens_hsa046401.29630632
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28140624
38Antigen processing and presentation_Homo sapiens_hsa046121.22392564
39Salmonella infection_Homo sapiens_hsa051321.20185958
40Viral myocarditis_Homo sapiens_hsa054161.18791640
41Shigellosis_Homo sapiens_hsa051311.10188852
42Phagosome_Homo sapiens_hsa041451.08147749
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01957542
44T cell receptor signaling pathway_Homo sapiens_hsa046600.97998325
45Lysosome_Homo sapiens_hsa041420.96517129
46Prolactin signaling pathway_Homo sapiens_hsa049170.96307928
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94693910
48Non-small cell lung cancer_Homo sapiens_hsa052230.93931803
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93339840
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85580242
51Caffeine metabolism_Homo sapiens_hsa002320.80532087
52Acute myeloid leukemia_Homo sapiens_hsa052210.77626234
53Type II diabetes mellitus_Homo sapiens_hsa049300.76443541
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.73561394
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72965214
56Amoebiasis_Homo sapiens_hsa051460.71472564
57Small cell lung cancer_Homo sapiens_hsa052220.70574968
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.62166894
59Epstein-Barr virus infection_Homo sapiens_hsa051690.61571137
60Chronic myeloid leukemia_Homo sapiens_hsa052200.56149417
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.56021422
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55875763
63Pancreatic cancer_Homo sapiens_hsa052120.53643173
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51533692
65Renal cell carcinoma_Homo sapiens_hsa052110.49978735
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.48089024
67HIF-1 signaling pathway_Homo sapiens_hsa040660.47773713
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46406507
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44574229
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43782509
71Viral carcinogenesis_Homo sapiens_hsa052030.43213347
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42161559
73Other glycan degradation_Homo sapiens_hsa005110.41411396
74Endocytosis_Homo sapiens_hsa041440.41091540
75Notch signaling pathway_Homo sapiens_hsa043300.40325840
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.39628578
77Dorso-ventral axis formation_Homo sapiens_hsa043200.39624638
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39448936
79ABC transporters_Homo sapiens_hsa020100.38307610
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38009643
81Endometrial cancer_Homo sapiens_hsa052130.34642601
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34393076
83Prion diseases_Homo sapiens_hsa050200.34098854
84Insulin resistance_Homo sapiens_hsa049310.33508666
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33006410
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32704257
87HTLV-I infection_Homo sapiens_hsa051660.32137198
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30688445
89Collecting duct acid secretion_Homo sapiens_hsa049660.29892308
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.28955443
91Platelet activation_Homo sapiens_hsa046110.28817477
92Choline metabolism in cancer_Homo sapiens_hsa052310.24844850
93MicroRNAs in cancer_Homo sapiens_hsa052060.24287792
94Inositol phosphate metabolism_Homo sapiens_hsa005620.24052606
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24005389
96GnRH signaling pathway_Homo sapiens_hsa049120.22393798
97Mineral absorption_Homo sapiens_hsa049780.21154602
98Regulation of autophagy_Homo sapiens_hsa041400.20680212
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20426867
100Complement and coagulation cascades_Homo sapiens_hsa046100.20407353
101MAPK signaling pathway_Homo sapiens_hsa040100.20212866
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20102698
103Systemic lupus erythematosus_Homo sapiens_hsa053220.18028181
104Proteoglycans in cancer_Homo sapiens_hsa052050.17749617
105p53 signaling pathway_Homo sapiens_hsa041150.17626996
106ErbB signaling pathway_Homo sapiens_hsa040120.16256973
107VEGF signaling pathway_Homo sapiens_hsa043700.16164509
108FoxO signaling pathway_Homo sapiens_hsa040680.15147888
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14766399
110Colorectal cancer_Homo sapiens_hsa052100.12546922
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09072549
112mTOR signaling pathway_Homo sapiens_hsa041500.08278479
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07225361
114Prostate cancer_Homo sapiens_hsa052150.06422571

Most similar genes based on co-expression Upload to Enrichr

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