GBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)9.55423452
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)9.55423452
3antigen processing and presentation of endogenous antigen (GO:0019883)8.33791860
4keratinization (GO:0031424)7.78255088
5peptide cross-linking (GO:0018149)7.42416219
6cilium or flagellum-dependent cell motility (GO:0001539)6.54263251
7axonemal dynein complex assembly (GO:0070286)6.50981883
8keratinocyte differentiation (GO:0030216)6.38608671
9response to type I interferon (GO:0034340)6.36620644
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.36432044
11type I interferon signaling pathway (GO:0060337)6.29604662
12cellular response to type I interferon (GO:0071357)6.29604662
13desmosome organization (GO:0002934)6.23771589
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.99140213
15cilium movement (GO:0003341)5.80611378
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.75340010
17positive regulation of gamma-delta T cell activation (GO:0046645)5.68090766
18epithelial cilium movement (GO:0003351)5.54525090
19axoneme assembly (GO:0035082)5.39889334
20transepithelial transport (GO:0070633)5.10265988
21response to interferon-alpha (GO:0035455)5.06651525
22keratinocyte development (GO:0003334)4.92771750
23epidermal cell differentiation (GO:0009913)4.91158842
24regulation of type I interferon-mediated signaling pathway (GO:0060338)4.87047514
25fucose catabolic process (GO:0019317)4.78314741
26L-fucose metabolic process (GO:0042354)4.78314741
27L-fucose catabolic process (GO:0042355)4.78314741
28regulation of cilium movement (GO:0003352)4.72773204
29establishment of skin barrier (GO:0061436)4.63279480
30regulation of gamma-delta T cell differentiation (GO:0045586)4.51023365
31cellular response to interferon-beta (GO:0035458)4.50167600
32establishment of tissue polarity (GO:0007164)4.40878511
33establishment of planar polarity (GO:0001736)4.40878511
34regulation of gamma-delta T cell activation (GO:0046643)4.36463658
35interferon-gamma-mediated signaling pathway (GO:0060333)4.35578938
36response to interferon-beta (GO:0035456)4.30803492
37positive regulation of interferon-alpha production (GO:0032727)4.30682070
38tolerance induction (GO:0002507)4.27125843
39regulation of interleukin-12 biosynthetic process (GO:0045075)4.23945730
40T cell migration (GO:0072678)4.14396217
41regulation of interferon-alpha production (GO:0032647)4.07182708
42negative T cell selection (GO:0043383)4.05939476
43motile cilium assembly (GO:0044458)4.05010371
44primary alcohol catabolic process (GO:0034310)4.01974210
45response to interleukin-15 (GO:0070672)4.01829548
46keratinocyte proliferation (GO:0043616)3.99118475
47regulation of response to interferon-gamma (GO:0060330)3.98986618
48JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.98542656
49lateral sprouting from an epithelium (GO:0060601)3.91195545
50cellular response to interferon-alpha (GO:0035457)3.90309324
51antigen processing and presentation via MHC class Ib (GO:0002475)3.88109114
52negative thymic T cell selection (GO:0045060)3.86227345
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85715195
54cellular response to interleukin-15 (GO:0071350)3.80825333
55positive regulation of natural killer cell differentiation (GO:0032825)3.80242377
56negative regulation of viral genome replication (GO:0045071)3.76484864
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70368149
58regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.68655021
59retinoic acid metabolic process (GO:0042573)3.64863103
60regulation of water loss via skin (GO:0033561)3.62105581
61regulation of RIG-I signaling pathway (GO:0039535)3.57813212
62epidermis development (GO:0008544)3.57538595
63molting cycle (GO:0042303)3.56426022
64hair cycle (GO:0042633)3.56426022
65positive thymic T cell selection (GO:0045059)3.54782252
66interferon-gamma production (GO:0032609)3.52664487
67bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51990008
68regulation of isotype switching to IgG isotypes (GO:0048302)3.46196105
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38965212
70positive regulation of humoral immune response (GO:0002922)3.38785366
71JAK-STAT cascade (GO:0007259)3.35148324
72cornea development in camera-type eye (GO:0061303)3.31462001
73* cellular response to interferon-gamma (GO:0071346)3.30258402
74defense response to virus (GO:0051607)3.29652373
75cellular response to exogenous dsRNA (GO:0071360)3.29134348
76positive T cell selection (GO:0043368)3.28075601
77regulation of regulatory T cell differentiation (GO:0045589)3.27085526
78positive regulation by symbiont of host defense response (GO:0052509)3.26517224
79modulation by symbiont of host defense response (GO:0052031)3.26517224
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26517224
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26517224
82positive regulation by organism of defense response of other organism involved in symbiotic interact3.26517224
83modulation by symbiont of host immune response (GO:0052553)3.26517224
84negative regulation of cell killing (GO:0031342)3.24657092
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24657092
86regulation of B cell receptor signaling pathway (GO:0050855)3.20440752
87cellular response to virus (GO:0098586)3.18669861
88cilium organization (GO:0044782)3.18596365
89regulation of memory T cell differentiation (GO:0043380)3.18070199
90T cell selection (GO:0045058)3.17896429
91multicellular organismal water homeostasis (GO:0050891)3.15599502
92regulation of interferon-beta biosynthetic process (GO:0045357)3.15261120
93thymic T cell selection (GO:0045061)3.12704557
94NIK/NF-kappaB signaling (GO:0038061)3.09655978
95regulation of T cell tolerance induction (GO:0002664)3.09339006
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09165968
97neural tube formation (GO:0001841)3.08734808
98preassembly of GPI anchor in ER membrane (GO:0016254)3.08187958
99piRNA metabolic process (GO:0034587)3.07386684
100positive regulation of interferon-beta production (GO:0032728)3.07173541
101exogenous drug catabolic process (GO:0042738)3.07011731
102fucosylation (GO:0036065)3.06368537
103immunoglobulin mediated immune response (GO:0016064)3.06149069
104ectoderm development (GO:0007398)3.04470462
105adaptation of signaling pathway (GO:0023058)3.04170189
106negative regulation of T cell differentiation in thymus (GO:0033085)3.03405825
107cilium assembly (GO:0042384)3.03191860
108growth hormone receptor signaling pathway (GO:0060396)3.02441541
109defense response to protozoan (GO:0042832)3.01796960
110negative regulation of telomere maintenance (GO:0032205)3.01555321
111thyroid hormone generation (GO:0006590)2.99010383
112regulation of microtubule-based movement (GO:0060632)2.97513664
113centriole replication (GO:0007099)2.97100130
114DNA deamination (GO:0045006)2.97012065
115platelet dense granule organization (GO:0060155)2.96906230
116leukocyte aggregation (GO:0070486)2.95287572
117regulation of natural killer cell differentiation (GO:0032823)2.93674250
118regulation of alpha-beta T cell proliferation (GO:0046640)2.92948860
119regulation of ruffle assembly (GO:1900027)2.92041209
120positive regulation of B cell mediated immunity (GO:0002714)2.91889828
121positive regulation of immunoglobulin mediated immune response (GO:0002891)2.91889828
122one-carbon compound transport (GO:0019755)2.91703945
123regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.91393106
124thyroid hormone metabolic process (GO:0042403)2.91315445
125protein localization to cilium (GO:0061512)2.90355979
126water homeostasis (GO:0030104)2.90015232
127cilium morphogenesis (GO:0060271)2.89619790
128positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.89333548
129* response to interferon-gamma (GO:0034341)2.87594322
130regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.87347302
131positive regulation of antigen processing and presentation (GO:0002579)2.87095136
132regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.87012525
133DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.86852504
134response to protozoan (GO:0001562)2.86129390
135detection of light stimulus involved in visual perception (GO:0050908)2.85665989
136detection of light stimulus involved in sensory perception (GO:0050962)2.85665989
137diterpenoid biosynthetic process (GO:0016102)2.85535067
138T cell costimulation (GO:0031295)2.83138864
139T-helper 1 type immune response (GO:0042088)2.80868285
140retinol metabolic process (GO:0042572)2.80363424
141lymphocyte costimulation (GO:0031294)2.78862658
142pyrimidine-containing compound transmembrane transport (GO:0072531)2.78535414
143myeloid dendritic cell differentiation (GO:0043011)2.78138605
144water-soluble vitamin biosynthetic process (GO:0042364)2.77538915
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.77476638
146alpha-beta T cell activation (GO:0046631)2.75220443
147ethanol metabolic process (GO:0006067)2.75175352
148hemidesmosome assembly (GO:0031581)2.74102884
149microtubule bundle formation (GO:0001578)2.71015136
150positive regulation of isotype switching (GO:0045830)2.70897841
151T cell receptor signaling pathway (GO:0050852)2.70497636
152regulation of germinal center formation (GO:0002634)2.69728888
153hair follicle morphogenesis (GO:0031069)2.69523316
154positive regulation of response to cytokine stimulus (GO:0060760)2.69439930
155drug catabolic process (GO:0042737)2.67762127
156regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67568017
157left/right axis specification (GO:0070986)2.67137986
158macrophage activation involved in immune response (GO:0002281)2.66756618
159myeloid dendritic cell activation (GO:0001773)2.66581765
160protein polyglutamylation (GO:0018095)2.66427521
161lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65768943
162multicellular organism reproduction (GO:0032504)2.65536120
163positive regulation of chemokine biosynthetic process (GO:0045080)2.65458608
164GPI anchor metabolic process (GO:0006505)2.65230207
165regulation of chemokine biosynthetic process (GO:0045073)2.65113035
166negative regulation of type I interferon production (GO:0032480)2.64711260
167negative regulation of neurological system process (GO:0031645)2.63712996
168response to xenobiotic stimulus (GO:0009410)2.63627705
169detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63543961
170photoreceptor cell maintenance (GO:0045494)2.62946620
171negative regulation of acute inflammatory response (GO:0002674)2.62055668
172alpha-beta T cell differentiation (GO:0046632)2.61824742
173regulation of cytokine-mediated signaling pathway (GO:0001959)2.61556844
174response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60843261
175response to host immune response (GO:0052572)2.60843261
176terpenoid biosynthetic process (GO:0016114)2.60400989
177positive regulation of response to biotic stimulus (GO:0002833)2.60281062
178B cell mediated immunity (GO:0019724)2.59399402
179respiratory chain complex IV assembly (GO:0008535)2.59271241
180positive regulation of defense response to virus by host (GO:0002230)2.58987427
181regulation of keratinocyte proliferation (GO:0010837)2.58582925
182behavioral response to nicotine (GO:0035095)2.56478476
183centriole assembly (GO:0098534)2.56355592
184kynurenine metabolic process (GO:0070189)2.53232563
185cytidine deamination (GO:0009972)2.52545566
186cytidine metabolic process (GO:0046087)2.52545566
187cytidine catabolic process (GO:0006216)2.52545566
188nucleotide transmembrane transport (GO:1901679)2.49522018
189protein K11-linked deubiquitination (GO:0035871)2.48251721
190phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48223429
191cellular ketone body metabolic process (GO:0046950)2.48172747
192DNA methylation involved in gamete generation (GO:0043046)2.46924189
193intraciliary transport (GO:0042073)2.44008978
194phosphatidylserine acyl-chain remodeling (GO:0036150)2.43861587
195magnesium ion transport (GO:0015693)2.42494035
196positive regulation of oligodendrocyte differentiation (GO:0048714)2.41763390
197phenylpropanoid metabolic process (GO:0009698)2.40972329
198cellular component assembly involved in morphogenesis (GO:0010927)2.40522084
199phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37602742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.40920541
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.70662555
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.97324432
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.94540618
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.78994892
6* IRF8_21731497_ChIP-ChIP_J774_Mouse4.61439949
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.02865989
8VDR_22108803_ChIP-Seq_LS180_Human3.90696349
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18630630
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.18309016
11ZNF274_21170338_ChIP-Seq_K562_Hela3.09751224
12* IRF8_27001747_Chip-Seq_BMDM_Mouse3.01336847
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72155948
14RUNX_20019798_ChIP-Seq_JUKART_Human2.70866572
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61764870
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53750474
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42945186
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42441747
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33894788
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25274552
21GATA1_22025678_ChIP-Seq_K562_Human2.23607076
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22365694
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21715799
24* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.17892828
25MYB_26560356_Chip-Seq_TH2_Human2.17565854
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12810680
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05603227
28MAF_26560356_Chip-Seq_TH1_Human2.04089289
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99058488
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97095609
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95142609
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90474235
33* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88618883
34MYB_26560356_Chip-Seq_TH1_Human1.87100417
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86190992
36GBX2_23144817_ChIP-Seq_PC3_Human1.85660154
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77364742
38ER_23166858_ChIP-Seq_MCF-7_Human1.74498570
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74408535
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.73976943
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.73066466
42BCAT_22108803_ChIP-Seq_LS180_Human1.69214540
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68925094
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.67434296
45SCL_19346495_ChIP-Seq_HPC-7_Human1.67407398
46* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62465705
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61322596
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59918612
49* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59241820
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58579151
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.57974755
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.56865757
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56836705
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56252508
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55273685
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.54582001
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.52379014
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51320160
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50901588
60* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.48593756
61* RBPJ_21746931_ChIP-Seq_IB4_Human1.48063395
62UTX_26944678_Chip-Seq_JUKART_Human1.47801738
63* ETV1_20927104_ChIP-Seq_GIST48_Human1.47759686
64TP63_23658742_ChIP-Seq_EP156T_Human1.47191835
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46522193
66GATA3_27048872_Chip-Seq_THYMUS_Human1.43684079
67* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.43481675
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42779373
69* FOXA1_25329375_ChIP-Seq_VCAP_Human1.42767627
70* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42767627
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42519793
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.38792055
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38462615
74* GATA6_21074721_ChIP-Seq_CACO-2_Human1.37745450
75AR_25329375_ChIP-Seq_VCAP_Human1.37640212
76P300_19829295_ChIP-Seq_ESCs_Human1.36662389
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35914304
78SPI1_23127762_ChIP-Seq_K562_Human1.35096255
79PU_27001747_Chip-Seq_BMDM_Mouse1.34893281
80TCF4_22108803_ChIP-Seq_LS180_Human1.34142151
81* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33307089
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31712362
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.31228263
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.31071641
85MAF_26560356_Chip-Seq_TH2_Human1.29837638
86SPI1_23547873_ChIP-Seq_NB4_Human1.29525745
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29051323
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.28522025
89HOXB7_26014856_ChIP-Seq_BT474_Human1.27702798
90* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27274095
91SMAD4_21799915_ChIP-Seq_A2780_Human1.25717737
92CBP_20019798_ChIP-Seq_JUKART_Human1.24853965
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24853965
94* PHF8_20622853_ChIP-Seq_HELA_Human1.24495394
95VDR_24763502_ChIP-Seq_THP-1_Human1.24017646
96CEBPB_22108803_ChIP-Seq_LS180_Human1.23958407
97TAF15_26573619_Chip-Seq_HEK293_Human1.23294108
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23064449
99SOX2_19829295_ChIP-Seq_ESCs_Human1.22956927
100NANOG_19829295_ChIP-Seq_ESCs_Human1.22956927
101* AR_20517297_ChIP-Seq_VCAP_Human1.22569598
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22153526
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22110633
104NANOG_20526341_ChIP-Seq_ESCs_Human1.21629188
105NCOR_22424771_ChIP-Seq_293T_Human1.21528856
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.20000843
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19912808
108HTT_18923047_ChIP-ChIP_STHdh_Human1.19431874
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19271122
110CDX2_22108803_ChIP-Seq_LS180_Human1.18793235
111TCF4_23295773_ChIP-Seq_U87_Human1.18458590
112MYC_22102868_ChIP-Seq_BL_Human1.17995137
113IGF1R_20145208_ChIP-Seq_DFB_Human1.17560166
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17155430
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17154969
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17048311
117* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16877649
118* HNFA_21074721_ChIP-Seq_CACO-2_Human1.16351836
119TCF7_22412390_ChIP-Seq_EML_Mouse1.15411032
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15320973
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15033603
122ERG_20517297_ChIP-Seq_VCAP_Human1.15017881
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.14985871
124FUS_26573619_Chip-Seq_HEK293_Human1.14615273
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14517350
126RXR_22108803_ChIP-Seq_LS180_Human1.14276572
127GATA3_26560356_Chip-Seq_TH2_Human1.13336005
128VDR_21846776_ChIP-Seq_THP-1_Human1.13317457
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.13023609
130TP63_17297297_ChIP-ChIP_HaCaT_Human1.12957792
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12795510
132TP53_22573176_ChIP-Seq_HFKS_Human1.12301438
133STAT3_23295773_ChIP-Seq_U87_Human1.12045152
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11578827
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11430338
136VDR_24787735_ChIP-Seq_THP-1_Human1.11299051
137* NFYB_21822215_ChIP-Seq_K562_Human1.11294560
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.11144798
139EWS_26573619_Chip-Seq_HEK293_Human1.10708441
140TP53_16413492_ChIP-PET_HCT116_Human1.09726797
141FOXH1_21741376_ChIP-Seq_EPCs_Human1.09408331
142CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09401251
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07585269
144TCF4_18268006_ChIP-ChIP_LS174T_Human1.07463912
145SMRT_27268052_Chip-Seq_Bcells_Human1.05945706
146SMAD3_21741376_ChIP-Seq_EPCs_Human1.05809402
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05470336
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05179975
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05168415
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04851995
151GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03019718
152ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02494821
153LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02417585
154AHR_22903824_ChIP-Seq_MCF-7_Human1.02322948
155LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01405956
156TBL1_22424771_ChIP-Seq_293T_Human1.00449446
157* NFYA_21822215_ChIP-Seq_K562_Human1.00053278
158EGR1_19032775_ChIP-ChIP_M12_Human0.99205614
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98614763
160NOTCH1_21737748_ChIP-Seq_TLL_Human0.97729494
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97560222
162TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95193763
163GATA1_19941827_ChIP-Seq_MEL_Mouse0.94337838
164GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93355905
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92644210
166KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90830566
167KDM2B_26808549_Chip-Seq_DND41_Human0.89770143
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.89594567
169NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85343926
170SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84307859
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83249531
172FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82092691
173CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80969622
174ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80751861
175CLOCK_20551151_ChIP-Seq_293T_Human0.80230618
176NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76393487
177* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75493234
178CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74652524
179TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74570956
180GATA2_19941826_ChIP-Seq_K562_Human0.72746963
181GATA1_19941826_ChIP-Seq_K562_Human0.72239264
182PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71661675
183CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71578187
184CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69808661
185PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69444691
186FOXO3_23340844_ChIP-Seq_DLD1_Human0.68953558
187SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68450091
188BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68081545
189PPAR_26484153_Chip-Seq_NCI-H1993_Human0.67533935
190GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61872186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.23603821
2MP0010234_abnormal_vibrissa_follicle5.94485980
3MP0001835_abnormal_antigen_presentation4.67874729
4MP0009785_altered_susceptibility_to3.96630995
5MP0002796_impaired_skin_barrier3.93829994
6MP0003724_increased_susceptibility_to3.47006663
7MP0010678_abnormal_skin_adnexa3.44348670
8MP0000685_abnormal_immune_system3.40224640
9MP0005671_abnormal_response_to3.37311136
10MP0000467_abnormal_esophagus_morphology3.36121401
11MP0004885_abnormal_endolymph3.00817905
12MP0008875_abnormal_xenobiotic_pharmacok2.98688181
13MP0000579_abnormal_nail_morphology2.93202681
14MP0003763_abnormal_thymus_physiology2.90086443
15MP0005025_abnormal_response_to2.88308394
16MP0005387_immune_system_phenotype2.84342354
17MP0001790_abnormal_immune_system2.84342354
18MP0002166_altered_tumor_susceptibility2.78909432
19MP0004510_myositis2.72985886
20MP0003878_abnormal_ear_physiology2.68289161
21MP0005377_hearing/vestibular/ear_phenot2.68289161
22MP0006082_CNS_inflammation2.63873722
23MP0002006_tumorigenesis2.61490855
24MP0003436_decreased_susceptibility_to2.60474150
25MP0001800_abnormal_humoral_immune2.59803911
26MP0005000_abnormal_immune_tolerance2.59219027
27MP0000427_abnormal_hair_cycle2.44615329
28MP0002723_abnormal_immune_serum2.42610624
29MP0002234_abnormal_pharynx_morphology2.40113606
30MP0002452_abnormal_antigen_presenting2.29547563
31MP0002148_abnormal_hypersensitivity_rea2.26520934
32MP0001819_abnormal_immune_cell2.18209200
33MP0000566_synostosis2.18106757
34MP0002419_abnormal_innate_immunity2.17839278
35MP0002420_abnormal_adaptive_immunity2.16379573
36MP0002254_reproductive_system_inflammat2.15862329
37MP0001853_heart_inflammation2.06740081
38MP0002095_abnormal_skin_pigmentation2.06349084
39MP0004947_skin_inflammation2.06348929
40MP0005501_abnormal_skin_physiology2.01562542
41MP0000762_abnormal_tongue_morphology1.99243249
42MP0010155_abnormal_intestine_physiology1.90810821
43MP0003303_peritoneal_inflammation1.86981578
44MP0002398_abnormal_bone_marrow1.86271772
45MP0003195_calcinosis1.85686957
46MP0001216_abnormal_epidermal_layer1.85281045
47MP0002653_abnormal_ependyma_morphology1.85137005
48MP0003300_gastrointestinal_ulcer1.84046589
49MP0003191_abnormal_cellular_cholesterol1.79982777
50MP0008877_abnormal_DNA_methylation1.79190393
51MP0005464_abnormal_platelet_physiology1.78749402
52MP0002405_respiratory_system_inflammati1.76619120
53MP0000716_abnormal_immune_system1.76119533
54MP0001845_abnormal_inflammatory_respons1.73764774
55MP0009333_abnormal_splenocyte_physiolog1.67554851
56MP0008469_abnormal_protein_level1.67274067
57MP0005075_abnormal_melanosome_morpholog1.65785855
58MP0002876_abnormal_thyroid_physiology1.64391893
59MP0003045_fibrosis1.63323121
60MP0009764_decreased_sensitivity_to1.61750313
61MP0001533_abnormal_skeleton_physiology1.58151334
62MP0008872_abnormal_physiological_respon1.55686075
63MP0003448_altered_tumor_morphology1.55536998
64MP0002098_abnormal_vibrissa_morphology1.55280904
65MP0001873_stomach_inflammation1.47046521
66MP0008789_abnormal_olfactory_epithelium1.45548780
67MP0010771_integument_phenotype1.45120009
68MP0002722_abnormal_immune_system1.44503049
69MP0000689_abnormal_spleen_morphology1.42457276
70MP0002102_abnormal_ear_morphology1.42371866
71MP0002429_abnormal_blood_cell1.40997954
72MP0009780_abnormal_chondrocyte_physiolo1.33660171
73MP0002837_dystrophic_cardiac_calcinosis1.33498168
74MP0000343_altered_response_to1.33166754
75MP0001765_abnormal_ion_homeostasis1.32911077
76MP0002998_abnormal_bone_remodeling1.31862669
77MP0000703_abnormal_thymus_morphology1.30812481
78MP0001984_abnormal_olfaction1.26730394
79MP0005310_abnormal_salivary_gland1.25995207
80MP0005360_urolithiasis1.24905501
81MP0004133_heterotaxia1.24409570
82MP0009053_abnormal_anal_canal1.24372006
83MP0002396_abnormal_hematopoietic_system1.24192611
84MP0001485_abnormal_pinna_reflex1.21846413
85MP0009278_abnormal_bone_marrow1.20920324
86MP0005551_abnormal_eye_electrophysiolog1.20371855
87MP0000371_diluted_coat_color1.18823100
88MP0001501_abnormal_sleep_pattern1.16297585
89MP0003011_delayed_dark_adaptation1.15002066
90MP0004808_abnormal_hematopoietic_stem1.14877631
91MP0000470_abnormal_stomach_morphology1.14356972
92MP0004130_abnormal_muscle_cell1.14308174
93MP0000377_abnormal_hair_follicle1.14250089
94MP0001851_eye_inflammation1.14181024
95MP0009763_increased_sensitivity_to1.12661807
96MP0002138_abnormal_hepatobiliary_system1.12281732
97MP0005253_abnormal_eye_physiology1.10664446
98MP0001545_abnormal_hematopoietic_system1.10635088
99MP0005397_hematopoietic_system_phenotyp1.10635088
100MP0005365_abnormal_bile_salt1.09422065
101MP0003866_abnormal_defecation1.09171687
102MP0009840_abnormal_foam_cell1.07142288
103MP0000609_abnormal_liver_physiology1.06318561
104MP0003453_abnormal_keratinocyte_physiol1.05754475
105MP0005670_abnormal_white_adipose1.01914132
106MP0003828_pulmonary_edema1.01158254
107MP0002277_abnormal_respiratory_mucosa1.00754348
108MP0000858_altered_metastatic_potential1.00120464
109MP0004381_abnormal_hair_follicle0.99833740
110MP0000613_abnormal_salivary_gland0.98859707
111MP0005083_abnormal_biliary_tract0.98052873
112MP0002933_joint_inflammation0.97271943
113MP0005275_abnormal_skin_tensile0.94277434
114MP0001968_abnormal_touch/_nociception0.93723606
115MP0005058_abnormal_lysosome_morphology0.93500069
116MP0003646_muscle_fatigue0.92007996
117MP0002139_abnormal_hepatobiliary_system0.91912093
118MP0003787_abnormal_imprinting0.91190071
119MP0004019_abnormal_vitamin_homeostasis0.91104145
120MP0005023_abnormal_wound_healing0.89685600
121MP0006072_abnormal_retinal_apoptosis0.88181683
122MP0005636_abnormal_mineral_homeostasis0.87577942
123MP0004264_abnormal_extraembryonic_tissu0.87396181
124MP0008775_abnormal_heart_ventricle0.86881596
125MP0000604_amyloidosis0.86684380
126MP0010329_abnormal_lipoprotein_level0.86641373
127MP0000367_abnormal_coat/_hair0.86324358
128MP0003638_abnormal_response/metabolism_0.85469868
129MP0001919_abnormal_reproductive_system0.84957582
130MP0000465_gastrointestinal_hemorrhage0.83299908
131MP0005666_abnormal_adipose_tissue0.83296574
132MP0002736_abnormal_nociception_after0.82342554
133MP0005645_abnormal_hypothalamus_physiol0.82331541
134MP0000249_abnormal_blood_vessel0.82035173
135MP0005499_abnormal_olfactory_system0.81923293
136MP0005394_taste/olfaction_phenotype0.81923293
137MP0003075_altered_response_to0.81347102
138MP0002282_abnormal_trachea_morphology0.79138896
139MP0003880_abnormal_central_pattern0.78055600
140MP0008961_abnormal_basal_metabolism0.77665131
141MP0000647_abnormal_sebaceous_gland0.77642771
142MP0000383_abnormal_hair_follicle0.77471412
143MP0000569_abnormal_digit_pigmentation0.77110005
144MP0005166_decreased_susceptibility_to0.76889115
145MP0009115_abnormal_fat_cell0.75360413
146MP0009046_muscle_twitch0.75201194
147MP0005389_reproductive_system_phenotype0.75191155
148MP0003868_abnormal_feces_composition0.74282970
149MP0003806_abnormal_nucleotide_metabolis0.72062215
150MP0010386_abnormal_urinary_bladder0.71977946
151MP0000372_irregular_coat_pigmentation0.70930592
152MP0005167_abnormal_blood-brain_barrier0.69853819
153MP0005165_increased_susceptibility_to0.68682195
154MP0003186_abnormal_redox_activity0.67147533
155MP0005164_abnormal_response_to0.66860319
156MP0005319_abnormal_enzyme/_coenzyme0.66835719
157MP0004484_altered_response_of0.66453678
158MP0002168_other_aberrant_phenotype0.66174142
159MP0002971_abnormal_brown_adipose0.65927380
160MP0005646_abnormal_pituitary_gland0.65919239
161MP0009765_abnormal_xenobiotic_induced0.65501312
162MP0004185_abnormal_adipocyte_glucose0.64581425
163MP0009745_abnormal_behavioral_response0.64340306
164MP0005085_abnormal_gallbladder_physiolo0.63758248
165MP0004782_abnormal_surfactant_physiolog0.63052301
166MP0000631_abnormal_neuroendocrine_gland0.62868633
167MP0003252_abnormal_bile_duct0.62852327
168MP0002136_abnormal_kidney_physiology0.62472410
169MP0005390_skeleton_phenotype0.61952540
170MP0000598_abnormal_liver_morphology0.60690011
171MP0003786_premature_aging0.60098042
172MP0005334_abnormal_fat_pad0.59574669
173MP0001881_abnormal_mammary_gland0.58715304
174MP0003091_abnormal_cell_migration0.58425465
175MP0004142_abnormal_muscle_tone0.55590852
176MP0004147_increased_porphyrin_level0.55293300
177MP0004742_abnormal_vestibular_system0.52433772

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)7.65862834
2Chronic otitis media (HP:0000389)6.57443485
3Nasal polyposis (HP:0100582)5.50975067
4Abnormality of the nasal mucosa (HP:0000433)5.35635503
5Elevated erythrocyte sedimentation rate (HP:0003565)5.16801914
6Recurrent bronchitis (HP:0002837)4.91898687
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.87694350
8Absent/shortened dynein arms (HP:0200106)4.87262418
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.87262418
10Abnormal respiratory motile cilium morphology (HP:0005938)4.82943756
11Abnormal respiratory epithelium morphology (HP:0012253)4.82943756
12Eczematoid dermatitis (HP:0000976)4.80340067
13Alopecia of scalp (HP:0002293)4.47508165
14Abnormality of T cell number (HP:0011839)4.44189178
15Abnormal ciliary motility (HP:0012262)4.42593842
16Recurrent cutaneous fungal infections (HP:0011370)4.40531494
17Chronic mucocutaneous candidiasis (HP:0002728)4.40531494
18Abnormal respiratory motile cilium physiology (HP:0012261)4.37584498
19T lymphocytopenia (HP:0005403)4.36329528
20Myositis (HP:0100614)4.35001343
21Palmoplantar hyperkeratosis (HP:0000972)4.34014309
22Recurrent fungal infections (HP:0002841)4.30455627
23Abnormality of nail color (HP:0100643)4.24002322
24Palmar hyperkeratosis (HP:0010765)4.16876160
25Erythroderma (HP:0001019)4.14327919
26Lip pit (HP:0100267)4.09516887
27Rhinitis (HP:0012384)4.02676470
28Chronic bronchitis (HP:0004469)3.99461464
29Autoimmune thrombocytopenia (HP:0001973)3.98355614
30Recurrent viral infections (HP:0004429)3.92354636
31Plantar hyperkeratosis (HP:0007556)3.86950831
32Chronic sinusitis (HP:0011109)3.80520339
33Recurrent abscess formation (HP:0002722)3.62587920
34Bronchiectasis (HP:0002110)3.60234519
35Abnormality of the axillary hair (HP:0100134)3.50994019
36Abnormality of secondary sexual hair (HP:0009888)3.50994019
37Orchitis (HP:0100796)3.50134810
38Recurrent skin infections (HP:0001581)3.47836832
39Pancreatic cysts (HP:0001737)3.46216117
40Abnormality of T cells (HP:0002843)3.39591003
41Recurrent bacterial skin infections (HP:0005406)3.36475919
42Spontaneous hematomas (HP:0007420)3.23695208
43Recurrent gram-negative bacterial infections (HP:0005420)3.20832019
44Autoimmune hemolytic anemia (HP:0001890)3.18649544
45Increased IgM level (HP:0003496)3.18032247
46Stomatitis (HP:0010280)3.15046188
47Optic neuritis (HP:0100653)3.11192054
48Retrobulbar optic neuritis (HP:0100654)3.11192054
49Vasculitis (HP:0002633)3.10511911
50Fragile nails (HP:0001808)3.09531654
51Hypotrichosis (HP:0001006)3.09095242
52Gingival bleeding (HP:0000225)3.08409537
53Pancreatic fibrosis (HP:0100732)3.08407587
54True hermaphroditism (HP:0010459)3.07866395
55Chronic diarrhea (HP:0002028)3.07408049
56Mediastinal lymphadenopathy (HP:0100721)3.06584617
57Abnormal delayed hypersensitivity skin test (HP:0002963)3.06579649
58Pustule (HP:0200039)3.05453374
59Furrowed tongue (HP:0000221)3.03864269
60Hemoptysis (HP:0002105)3.02102589
61Severe combined immunodeficiency (HP:0004430)3.00986444
62Joint swelling (HP:0001386)2.99920363
63Molar tooth sign on MRI (HP:0002419)2.98084088
64Abnormality of midbrain morphology (HP:0002418)2.98084088
65Corneal erosion (HP:0200020)2.95008916
66Sparse eyelashes (HP:0000653)2.92991517
67Congenital ichthyosiform erythroderma (HP:0007431)2.92001681
68Abnormality of the fingertips (HP:0001211)2.90695046
69Arterial thrombosis (HP:0004420)2.88381556
70Combined immunodeficiency (HP:0005387)2.87788196
71Hypoplastic labia majora (HP:0000059)2.83542781
72Hypergammaglobulinemia (HP:0010702)2.81225867
73Eosinophilia (HP:0001880)2.75263974
74Panhypogammaglobulinemia (HP:0003139)2.73223949
75Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.72001941
76Interstitial pulmonary disease (HP:0006530)2.71591278
77Abnormality of eosinophils (HP:0001879)2.65497634
78Onycholysis (HP:0001806)2.63458990
79Myocardial infarction (HP:0001658)2.61923138
80Leukocytosis (HP:0001974)2.61215906
81Nephronophthisis (HP:0000090)2.60636127
82Abnormality of the renal cortex (HP:0011035)2.60290358
83Nail dystrophy (HP:0008404)2.57592651
84Abnormality of macrophages (HP:0004311)2.57433865
85Bronchitis (HP:0012387)2.57247537
86Abnormality of the labia majora (HP:0012881)2.57046864
87Systemic lupus erythematosus (HP:0002725)2.56425436
88Inflammation of the large intestine (HP:0002037)2.54859891
89Colitis (HP:0002583)2.52309404
90Meningitis (HP:0001287)2.51890345
91Pulmonary infiltrates (HP:0002113)2.51672590
92Abnormality of T cell physiology (HP:0011840)2.51346382
93Conical tooth (HP:0000698)2.51112972
94Gingivitis (HP:0000230)2.50881742
95IgG deficiency (HP:0004315)2.50673108
96Basal ganglia calcification (HP:0002135)2.50662082
97Increased IgE level (HP:0003212)2.47308779
98Cheilitis (HP:0100825)2.45139989
99Pulmonary embolism (HP:0002204)2.45088235
100Chronic hepatic failure (HP:0100626)2.44993153
101Thyroiditis (HP:0100646)2.44793318
102Epistaxis (HP:0000421)2.44039021
103Gastrointestinal inflammation (HP:0004386)2.44007887
104Milia (HP:0001056)2.42681450
105Absent eyelashes (HP:0000561)2.41710367
106Parakeratosis (HP:0001036)2.41481578
107Hypoplasia of the thymus (HP:0000778)2.39893409
108Abnormality of B cell number (HP:0010975)2.38948204
109B lymphocytopenia (HP:0010976)2.38948204
110Keratoconjunctivitis (HP:0001096)2.37100151
111Emphysema (HP:0002097)2.36908909
112Sparse scalp hair (HP:0002209)2.36890111
113Abnormality of the renal medulla (HP:0100957)2.35851186
114Agammaglobulinemia (HP:0004432)2.35649796
115Granulocytopenia (HP:0001913)2.35356081
116Thrombocytosis (HP:0001894)2.34558486
117Ectropion (HP:0000656)2.32665275
118Woolly hair (HP:0002224)2.32247161
119Anorexia (HP:0002039)2.31340962
120Duplicated collecting system (HP:0000081)2.30684910
121Joint hemorrhage (HP:0005261)2.30247003
122Abnormality of the salivary glands (HP:0010286)2.29195791
123Medial flaring of the eyebrow (HP:0010747)2.28712987
124Periodontitis (HP:0000704)2.28410169
125Thick nail (HP:0001805)2.26505444
126Congenital stationary night blindness (HP:0007642)2.25708816
127Tubular atrophy (HP:0000092)2.25167367
128IgM deficiency (HP:0002850)2.24810314
129Keratoconjunctivitis sicca (HP:0001097)2.22802730
130Gastrointestinal infarctions (HP:0005244)2.22522954
131Chest pain (HP:0100749)2.20924117
132Oligodontia (HP:0000677)2.20774756
133Abnormality of the renal collecting system (HP:0004742)2.20679334
134Cystic liver disease (HP:0006706)2.20544472
135Popliteal pterygium (HP:0009756)2.20354122
136Prolonged bleeding time (HP:0003010)2.20216032
137Fair hair (HP:0002286)2.18815615
138Abnormal hair laboratory examination (HP:0003328)2.18573984
139Hematochezia (HP:0002573)2.18125748
140Cellulitis (HP:0100658)2.15724299
141Lymphopenia (HP:0001888)2.13290970
142Decreased circulating renin level (HP:0003351)2.13158316
143Recurrent sinusitis (HP:0011108)2.12615452
144Porencephaly (HP:0002132)2.12391021
145Hyperactive renin-angiotensin system (HP:0000841)2.11590796
146Esophageal varix (HP:0002040)2.09812937
147Abnormality of cells of the lymphoid lineage (HP:0012140)2.08888603
148Thrombophlebitis (HP:0004418)2.08531956
149IgA deficiency (HP:0002720)2.08354443
150Encephalitis (HP:0002383)2.05122209
151Gangrene (HP:0100758)2.04748882
152Erythema (HP:0010783)2.04698738
153Skin ulcer (HP:0200042)2.02688439
154Absent hair (HP:0002298)2.01708534
155Reduced subcutaneous adipose tissue (HP:0003758)2.01638651
156Type II lissencephaly (HP:0007260)2.00938090
157Congenital, generalized hypertrichosis (HP:0004540)1.98428680
158Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97667606
159Labial hypoplasia (HP:0000066)1.97207311
160Purpura (HP:0000979)1.96377785
161Chronic obstructive pulmonary disease (HP:0006510)1.95972131
162Obstructive lung disease (HP:0006536)1.95972131
163Complement deficiency (HP:0004431)1.95227873
164Abnormal rod and cone electroretinograms (HP:0008323)1.94055003
165Mesangial abnormality (HP:0001966)1.92766937
166Abnormality of the endocardium (HP:0004306)1.89166823
167Pili torti (HP:0003777)1.88533531
168Tetraparesis (HP:0002273)1.87906654
169Aplasia/hypoplasia of the uterus (HP:0008684)1.87456797
170Right ventricular cardiomyopathy (HP:0011663)1.87092522
171Hypohidrosis (HP:0000966)1.86944181
172Depressed nasal tip (HP:0000437)1.86874989
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.85185454
174Portal hypertension (HP:0001409)1.84037664
175Urticaria (HP:0001025)1.83700172
176Stomach cancer (HP:0012126)1.81202924
177Blepharitis (HP:0000498)1.80780710
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.79772850
179Recurrent corneal erosions (HP:0000495)1.78959879
180Congenital hepatic fibrosis (HP:0002612)1.78610548
181Abnormal drinking behavior (HP:0030082)1.78022530
182Polydipsia (HP:0001959)1.78022530
183Brittle hair (HP:0002299)1.76998310
184Asplenia (HP:0001746)1.76965543
185Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74152414
186Generalized hypopigmentation of hair (HP:0011358)1.73676599
187Palmoplantar keratoderma (HP:0000982)1.73395116
188Renal cortical cysts (HP:0000803)1.70857597
189Abolished electroretinogram (ERG) (HP:0000550)1.70347887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.94802114
2TYK24.77887124
3MAPKAPK34.41304890
4FRK4.32038774
5JAK33.70932118
6TXK3.62709815
7IKBKE3.54612766
8BMPR1B3.46000471
9JAK13.44634812
10MAP4K13.26198923
11FGFR32.93545763
12MAP3K142.80080482
13KIT2.78669568
14ADRBK22.73462625
15TBK12.67627311
16MAP3K62.56921535
17TLK12.50923519
18EPHA22.35406465
19GRK12.32337234
20ERBB32.24680412
21MAP4K22.14594436
22WNK42.13449943
23ZAP702.07307115
24STK241.90445995
25EPHA31.83402628
26PINK11.79500754
27BCR1.78702245
28MAP3K21.77473216
29EPHB11.75959024
30MAPK151.75039859
31ERN11.68539942
32ZAK1.67767337
33TNIK1.63551987
34MAP2K61.61472599
35FER1.56424911
36ITK1.55271074
37STK391.53200057
38NME11.51177218
39TGFBR21.48798706
40MAPK131.47939871
41IRAK41.47529457
42NLK1.45824476
43SIK11.43206363
44TRPM71.42097072
45BLK1.41316758
46WNK31.40949918
47MAP3K131.39872979
48IKBKB1.37129390
49LCK1.36626247
50CSK1.35675873
51TEC1.34703716
52MAP3K31.34201429
53ACVR1B1.31563492
54IRAK31.25130365
55MUSK1.24540996
56JAK21.22477217
57RIPK11.17819831
58INSRR1.15240340
59STK101.13444823
60HCK1.12435040
61TRIM281.09400118
62MAPK111.07431465
63SYK1.05348643
64TGFBR11.04058470
65MARK31.03294220
66CHUK1.02161837
67BTK1.01913711
68ADRBK11.01773242
69PRKCI1.01654027
70TIE11.00711246
71CCNB11.00250647
72CSF1R0.97043132
73IRAK10.93732620
74MAP3K40.93600297
75CAMKK20.92001196
76RPS6KB20.89003142
77PAK30.88831542
78OXSR10.88605955
79PRKCE0.86910564
80NEK90.86749148
81PKN20.84409006
82KDR0.84310263
83CAMK1D0.78453818
84FLT30.76243232
85SIK30.76031310
86TTN0.73631043
87PRKCH0.70755966
88TAOK30.69109435
89NME20.68533884
90MAP3K70.67646710
91FES0.67461980
92PDGFRB0.66978064
93CAMK1G0.66931016
94PRKCQ0.65673360
95PIM10.64654734
96LYN0.64461635
97PTK2B0.64387879
98RIPK40.63811336
99SIK20.63686731
100EIF2AK20.62367618
101CSNK1G20.60925207
102BMX0.60835373
103SGK30.59341944
104GRK60.58657470
105CSNK1G10.57038555
106MAP2K20.56039584
107CSNK1G30.55764238
108NUAK10.54749986
109STK38L0.53495072
110TRIB30.52091476
111MATK0.50505579
112STK30.50261846
113OBSCN0.48876287
114EGFR0.46551398
115TNK20.46010437
116RPS6KA50.44989616
117PTK60.43494395
118IGF1R0.42963516
119LRRK20.42687105
120MST40.42023241
121PDK10.41709592
122MAPKAPK50.40622187
123EEF2K0.38796623
124CDK80.38323184
125MAP3K120.37357014
126CSNK1A1L0.36321559
127CASK0.36084772
128PIK3CA0.34492964
129HIPK20.34217973
130MAP3K100.33473091
131MAP2K70.33266720
132RPS6KA40.32590150
133DAPK20.32497854
134MAP2K30.31704940
135ABL10.31665779
136MAPK40.31374682
137FGR0.31354225
138NEK60.30762286
139PRKAA20.28646163
140PRKCA0.28187385
141MST1R0.27843422
142PRKCG0.27815260
143RET0.27319066
144PIM20.27305771
145INSR0.26641987
146VRK20.26321820
147PHKG10.25879934
148PHKG20.25879934
149VRK10.25431740
150DMPK0.25256597
151WNK10.24634589
152PRKCD0.24582791
153MAP2K10.24578647
154CSNK1A10.24278252
155PRKACA0.23490687
156PDGFRA0.23375106
157MAPK30.22829773
158CDK40.21573353
159FYN0.21151912
160MAP3K10.20805130
161PBK0.20692789
162CDK120.18130621
163SRC0.16722374
164GRK70.16400287

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.68637966
2Phototransduction_Homo sapiens_hsa047443.40223486
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.20276773
4Measles_Homo sapiens_hsa051623.11301192
5Linoleic acid metabolism_Homo sapiens_hsa005913.01115287
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83598540
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.82154185
8Staphylococcus aureus infection_Homo sapiens_hsa051502.79275570
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78487691
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.62860619
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62728471
12Leishmaniasis_Homo sapiens_hsa051402.56006362
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.43414126
14Chemical carcinogenesis_Homo sapiens_hsa052042.42708379
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.39564758
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39052953
17Graft-versus-host disease_Homo sapiens_hsa053322.36475279
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36067811
19Allograft rejection_Homo sapiens_hsa053302.32663596
20Jak-STAT signaling pathway_Homo sapiens_hsa046302.25344894
21Osteoclast differentiation_Homo sapiens_hsa043802.24770651
22Intestinal immune network for IgA production_Homo sapiens_hsa046722.22002297
23Antigen processing and presentation_Homo sapiens_hsa046122.12408625
24Herpes simplex infection_Homo sapiens_hsa051682.09764844
25Influenza A_Homo sapiens_hsa051642.07572029
26Histidine metabolism_Homo sapiens_hsa003402.06641530
27Ether lipid metabolism_Homo sapiens_hsa005652.02033028
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01271497
29Caffeine metabolism_Homo sapiens_hsa002322.00446770
30Retinol metabolism_Homo sapiens_hsa008301.97001552
31T cell receptor signaling pathway_Homo sapiens_hsa046601.94519657
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87104699
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.73363592
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72886008
35Malaria_Homo sapiens_hsa051441.71527956
36Tyrosine metabolism_Homo sapiens_hsa003501.71493295
37TNF signaling pathway_Homo sapiens_hsa046681.70934261
38Arachidonic acid metabolism_Homo sapiens_hsa005901.70290163
39Toxoplasmosis_Homo sapiens_hsa051451.68893218
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67129490
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63943339
42Hepatitis C_Homo sapiens_hsa051601.60216204
43Phenylalanine metabolism_Homo sapiens_hsa003601.59330627
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54350090
45Protein export_Homo sapiens_hsa030601.51093673
46beta-Alanine metabolism_Homo sapiens_hsa004101.48334727
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45480707
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44356104
49Hematopoietic cell lineage_Homo sapiens_hsa046401.41720392
50Butanoate metabolism_Homo sapiens_hsa006501.38928422
51African trypanosomiasis_Homo sapiens_hsa051431.38819962
52Viral myocarditis_Homo sapiens_hsa054161.34319047
53Pertussis_Homo sapiens_hsa051331.34037360
54Complement and coagulation cascades_Homo sapiens_hsa046101.30958540
55Basal transcription factors_Homo sapiens_hsa030221.28043208
56Hepatitis B_Homo sapiens_hsa051611.27916409
57Chemokine signaling pathway_Homo sapiens_hsa040621.27001653
58Legionellosis_Homo sapiens_hsa051341.25023645
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21642937
60B cell receptor signaling pathway_Homo sapiens_hsa046621.21145458
61Autoimmune thyroid disease_Homo sapiens_hsa053201.20209261
62Olfactory transduction_Homo sapiens_hsa047401.18455470
63Tuberculosis_Homo sapiens_hsa051521.18100964
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14404495
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10395175
66Type I diabetes mellitus_Homo sapiens_hsa049401.09466475
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.09047885
68Regulation of autophagy_Homo sapiens_hsa041401.07953672
69Apoptosis_Homo sapiens_hsa042101.06253803
70ABC transporters_Homo sapiens_hsa020101.06243818
71Cyanoamino acid metabolism_Homo sapiens_hsa004601.05823012
72Taste transduction_Homo sapiens_hsa047421.03156957
73Oxidative phosphorylation_Homo sapiens_hsa001901.01092212
74Acute myeloid leukemia_Homo sapiens_hsa052210.99818296
75Nicotine addiction_Homo sapiens_hsa050330.98997220
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.98581507
77Sphingolipid metabolism_Homo sapiens_hsa006000.96757197
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96083198
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95222115
80Prolactin signaling pathway_Homo sapiens_hsa049170.94985548
81Circadian rhythm_Homo sapiens_hsa047100.94184074
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.93961550
83PPAR signaling pathway_Homo sapiens_hsa033200.92183208
84Asthma_Homo sapiens_hsa053100.92164926
85Salivary secretion_Homo sapiens_hsa049700.90749177
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90416550
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.89573751
88Homologous recombination_Homo sapiens_hsa034400.85804556
89Fatty acid degradation_Homo sapiens_hsa000710.84152463
90Arginine biosynthesis_Homo sapiens_hsa002200.82335930
91Salmonella infection_Homo sapiens_hsa051320.81314436
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80468816
93Rheumatoid arthritis_Homo sapiens_hsa053230.78219322
94Insulin resistance_Homo sapiens_hsa049310.78198247
95Huntingtons disease_Homo sapiens_hsa050160.77012105
96p53 signaling pathway_Homo sapiens_hsa041150.76979091
97Glycerolipid metabolism_Homo sapiens_hsa005610.76052564
98Fanconi anemia pathway_Homo sapiens_hsa034600.72606746
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.69760104
100Pancreatic cancer_Homo sapiens_hsa052120.69180717
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67671269
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66853205
103Shigellosis_Homo sapiens_hsa051310.66729513
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66708927
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.66457623
106Platelet activation_Homo sapiens_hsa046110.64364708
107RNA polymerase_Homo sapiens_hsa030200.64354162
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63906882
109Lysine degradation_Homo sapiens_hsa003100.62867474
110Selenocompound metabolism_Homo sapiens_hsa004500.62081753
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61205154
112Sulfur metabolism_Homo sapiens_hsa009200.60221731
113Collecting duct acid secretion_Homo sapiens_hsa049660.59714890
114Ovarian steroidogenesis_Homo sapiens_hsa049130.58890950
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58249979
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57946814
117Serotonergic synapse_Homo sapiens_hsa047260.57896887
118HIF-1 signaling pathway_Homo sapiens_hsa040660.57703210
119Glutathione metabolism_Homo sapiens_hsa004800.56131681
120Renin secretion_Homo sapiens_hsa049240.54809369
121Fatty acid biosynthesis_Homo sapiens_hsa000610.54304059
122Parkinsons disease_Homo sapiens_hsa050120.54176068
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54121571
124Small cell lung cancer_Homo sapiens_hsa052220.53576402
125RNA degradation_Homo sapiens_hsa030180.51658057
126Notch signaling pathway_Homo sapiens_hsa043300.51648264
127Metabolic pathways_Homo sapiens_hsa011000.50704086
128Tryptophan metabolism_Homo sapiens_hsa003800.49508998
129Peroxisome_Homo sapiens_hsa041460.48556361
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46950780
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46912681
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46794384
133Alzheimers disease_Homo sapiens_hsa050100.46496147
134Chronic myeloid leukemia_Homo sapiens_hsa052200.46191842
135Fatty acid metabolism_Homo sapiens_hsa012120.45975445
136Amoebiasis_Homo sapiens_hsa051460.45792153
137Proteasome_Homo sapiens_hsa030500.44609428
138HTLV-I infection_Homo sapiens_hsa051660.44326161
139Calcium signaling pathway_Homo sapiens_hsa040200.43991016
140Vitamin digestion and absorption_Homo sapiens_hsa049770.41523208
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39836075
142Type II diabetes mellitus_Homo sapiens_hsa049300.39280992
143Circadian entrainment_Homo sapiens_hsa047130.38989987
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37849515
145Lysosome_Homo sapiens_hsa041420.36974300
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36499210
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35560983
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31376872
149Propanoate metabolism_Homo sapiens_hsa006400.30735808
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.29885338
151Nitrogen metabolism_Homo sapiens_hsa009100.29337817
152Viral carcinogenesis_Homo sapiens_hsa052030.29042702
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26619267
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26123887
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.25601243
156Prion diseases_Homo sapiens_hsa050200.23917160
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.23763528
158Other glycan degradation_Homo sapiens_hsa005110.22556143
159Proteoglycans in cancer_Homo sapiens_hsa052050.22289306
160Phagosome_Homo sapiens_hsa041450.21652109
161Epstein-Barr virus infection_Homo sapiens_hsa051690.21493083
162Dorso-ventral axis formation_Homo sapiens_hsa043200.21428627
163FoxO signaling pathway_Homo sapiens_hsa040680.20006631
164Starch and sucrose metabolism_Homo sapiens_hsa005000.18258013
165Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17253103
166Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15786979

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »