GBP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.95163774
2drug catabolic process (GO:0042737)9.37157765
3epoxygenase P450 pathway (GO:0019373)8.44546957
4regulation of fibrinolysis (GO:0051917)8.35798412
5glyoxylate metabolic process (GO:0046487)8.20827511
6omega-hydroxylase P450 pathway (GO:0097267)8.19905061
7negative regulation of fibrinolysis (GO:0051918)8.14632231
8L-phenylalanine catabolic process (GO:0006559)7.25503741
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.25503741
10complement activation, alternative pathway (GO:0006957)7.09573867
11fibrinolysis (GO:0042730)6.92624939
12regulation of protein activation cascade (GO:2000257)6.91764481
13urea metabolic process (GO:0019627)6.79040260
14cellular glucuronidation (GO:0052695)6.67043931
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.62046147
16L-phenylalanine metabolic process (GO:0006558)6.62046147
17bile acid biosynthetic process (GO:0006699)6.53948865
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.50219388
19regulation of complement activation (GO:0030449)6.43371185
20ethanol oxidation (GO:0006069)6.39307874
21drug metabolic process (GO:0017144)6.37728824
22uronic acid metabolic process (GO:0006063)6.36954208
23glucuronate metabolic process (GO:0019585)6.36954208
24nitrogen cycle metabolic process (GO:0071941)6.22171520
25oxidative demethylation (GO:0070989)6.19609758
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.14151287
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.14151287
28peptidyl-glutamic acid carboxylation (GO:0017187)6.04765458
29protein carboxylation (GO:0018214)6.04765458
30blood coagulation, intrinsic pathway (GO:0007597)6.04296392
31negative regulation of cholesterol transport (GO:0032375)5.86509762
32negative regulation of sterol transport (GO:0032372)5.86509762
33bile acid metabolic process (GO:0008206)5.71870439
34antigen processing and presentation of endogenous antigen (GO:0019883)5.68442075
35urea cycle (GO:0000050)5.67640998
36aromatic amino acid family catabolic process (GO:0009074)5.62544358
37serine family amino acid catabolic process (GO:0009071)5.59223394
38phenylpropanoid metabolic process (GO:0009698)5.56905139
39regulation of triglyceride catabolic process (GO:0010896)5.33763820
40response to type I interferon (GO:0034340)5.20304288
41cellular response to type I interferon (GO:0071357)5.18133023
42type I interferon signaling pathway (GO:0060337)5.18133023
43glycine metabolic process (GO:0006544)5.17894566
44ethanol metabolic process (GO:0006067)5.15375712
45bile acid and bile salt transport (GO:0015721)5.06900463
46negative regulation of blood coagulation (GO:0030195)4.99728093
47negative regulation of hemostasis (GO:1900047)4.99728093
48S-adenosylmethionine metabolic process (GO:0046500)4.96339622
49positive regulation of gamma-delta T cell activation (GO:0046645)4.95321468
50regulation of plasminogen activation (GO:0010755)4.78516175
51amino-acid betaine metabolic process (GO:0006577)4.76220929
52alkaloid metabolic process (GO:0009820)4.70170194
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.63551422
54protein activation cascade (GO:0072376)4.59760471
55triglyceride homeostasis (GO:0070328)4.58117526
56acylglycerol homeostasis (GO:0055090)4.58117526
57positive regulation of interferon-alpha production (GO:0032727)4.57095817
58negative regulation of coagulation (GO:0050819)4.53346565
59fat-soluble vitamin biosynthetic process (GO:0042362)4.50204356
60negative regulation of wound healing (GO:0061045)4.46357763
61response to interferon-alpha (GO:0035455)4.38571990
62imidazole-containing compound metabolic process (GO:0052803)4.35405181
63regulation of interferon-alpha production (GO:0032647)4.34928654
64phospholipid efflux (GO:0033700)4.32777488
65regulation of humoral immune response (GO:0002920)4.22137394
66hormone catabolic process (GO:0042447)4.21736752
67complement activation (GO:0006956)4.17822325
68tryptophan catabolic process (GO:0006569)4.17691573
69indole-containing compound catabolic process (GO:0042436)4.17691573
70indolalkylamine catabolic process (GO:0046218)4.17691573
71heme transport (GO:0015886)4.16161098
72regulation of RIG-I signaling pathway (GO:0039535)4.15418924
73positive regulation of hemostasis (GO:1900048)4.15334616
74positive regulation of blood coagulation (GO:0030194)4.15334616
75arginine metabolic process (GO:0006525)4.15132496
76serine family amino acid metabolic process (GO:0009069)4.11670131
77negative regulation of protein activation cascade (GO:2000258)4.08939727
78tyrosine metabolic process (GO:0006570)4.06415668
79complement activation, classical pathway (GO:0006958)4.06104903
80acute-phase response (GO:0006953)4.05617188
81T cell migration (GO:0072678)4.05375909
82interferon-gamma-mediated signaling pathway (GO:0060333)4.03985087
83response to interferon-beta (GO:0035456)3.94391700
84cholesterol efflux (GO:0033344)3.94061674
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.91947304
86defense response to protozoan (GO:0042832)3.89739082
87plasma lipoprotein particle remodeling (GO:0034369)3.87614374
88protein-lipid complex remodeling (GO:0034368)3.87614374
89macromolecular complex remodeling (GO:0034367)3.87614374
90negative regulation of lipase activity (GO:0060192)3.87110101
91high-density lipoprotein particle remodeling (GO:0034375)3.86991727
92cellular response to interferon-beta (GO:0035458)3.86557077
93steroid catabolic process (GO:0006706)3.84366247
94positive regulation of coagulation (GO:0050820)3.84283223
95positive regulation of lipoprotein lipase activity (GO:0051006)3.83519342
96positive regulation of triglyceride lipase activity (GO:0061365)3.83519342
97immunoglobulin mediated immune response (GO:0016064)3.82287111
98intestinal cholesterol absorption (GO:0030299)3.81337768
99alpha-amino acid catabolic process (GO:1901606)3.80399319
100flavonoid metabolic process (GO:0009812)3.75336406
101positive regulation by symbiont of host defense response (GO:0052509)3.75309498
102modulation by symbiont of host defense response (GO:0052031)3.75309498
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75309498
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75309498
105positive regulation by organism of defense response of other organism involved in symbiotic interact3.75309498
106modulation by symbiont of host immune response (GO:0052553)3.75309498
107xenobiotic metabolic process (GO:0006805)3.74364753
108aromatic amino acid family metabolic process (GO:0009072)3.73457727
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.72752434
110neutrophil activation involved in immune response (GO:0002283)3.71706698
111negative regulation of viral genome replication (GO:0045071)3.70354089
112tryptophan metabolic process (GO:0006568)3.68585079
113cytolysis (GO:0019835)3.68272387
114cellular ketone body metabolic process (GO:0046950)3.67529594
115L-methionine salvage (GO:0071267)3.66760583
116L-methionine biosynthetic process (GO:0071265)3.66760583
117amino acid salvage (GO:0043102)3.66760583
118regulation of cholesterol esterification (GO:0010872)3.64579443
119response to mercury ion (GO:0046689)3.64249906
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62841257
121response to protozoan (GO:0001562)3.60217051
122regulation of interleukin-12 biosynthetic process (GO:0045075)3.60160919
123daunorubicin metabolic process (GO:0044597)3.58710021
124polyketide metabolic process (GO:0030638)3.58710021
125doxorubicin metabolic process (GO:0044598)3.58710021
126primary alcohol catabolic process (GO:0034310)3.54475798
127sodium-independent organic anion transport (GO:0043252)3.54147725
128regulation of gamma-delta T cell differentiation (GO:0045586)3.54030067
129glutamate metabolic process (GO:0006536)3.53324186
130myeloid dendritic cell activation (GO:0001773)3.51712995
131negative regulation of complement activation (GO:0045916)3.50511321
132reverse cholesterol transport (GO:0043691)3.49441185
133regulation of gamma-delta T cell activation (GO:0046643)3.48496904
134regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.44183836
135T-helper 1 type immune response (GO:0042088)3.43981380
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.42874935
137positive regulation of natural killer cell differentiation (GO:0032825)3.40868147
138cellular response to exogenous dsRNA (GO:0071360)3.39599922
139regulation of type I interferon-mediated signaling pathway (GO:0060338)3.35869192
140regulation of interferon-beta biosynthetic process (GO:0045357)3.34865535
141regulation of B cell receptor signaling pathway (GO:0050855)3.30666281
142cellular extravasation (GO:0045123)3.29387947
143regulation of response to interferon-gamma (GO:0060330)3.29133834
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.27837141
145antigen processing and presentation via MHC class Ib (GO:0002475)3.23806422
146positive regulation of interferon-beta production (GO:0032728)3.23787417
147respiratory burst (GO:0045730)3.19688702
148mast cell activation (GO:0045576)3.19000559
149myeloid dendritic cell differentiation (GO:0043011)3.18951871
150lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17441914
151regulation of alpha-beta T cell proliferation (GO:0046640)3.17234375
152response to peptidoglycan (GO:0032494)3.16846092
153cellular response to interferon-gamma (GO:0071346)3.13379299
154cellular response to interferon-alpha (GO:0035457)3.11743596
155B cell mediated immunity (GO:0019724)3.10104954
156positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07721484
157positive regulation of B cell differentiation (GO:0045579)3.06325855
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.04887833
159cellular response to virus (GO:0098586)3.03896268
160regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.02647022
161positive regulation of humoral immune response (GO:0002922)3.02493707
162leukocyte aggregation (GO:0070486)3.01003758
163natural killer cell activation (GO:0030101)2.97880992
164natural killer cell mediated cytotoxicity (GO:0042267)2.97020465
165natural killer cell mediated immunity (GO:0002228)2.97020465
166myeloid cell activation involved in immune response (GO:0002275)2.96404333
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96304020
168positive regulation of antigen processing and presentation (GO:0002579)2.94289247
169cellular response to zinc ion (GO:0071294)2.92657491
170negative thymic T cell selection (GO:0045060)2.91398773
171defense response to virus (GO:0051607)2.90770897
172positive regulation of chemokine biosynthetic process (GO:0045080)2.89476554
173regulation of necroptotic process (GO:0060544)2.88266512
174regulation of chemokine biosynthetic process (GO:0045073)2.87711205
175interferon-gamma production (GO:0032609)2.87595168
176negative T cell selection (GO:0043383)2.87096227
177definitive hemopoiesis (GO:0060216)2.86248597
178positive regulation of immunoglobulin mediated immune response (GO:0002891)2.85890453
179positive regulation of B cell mediated immunity (GO:0002714)2.85890453
180regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85770615
181NIK/NF-kappaB signaling (GO:0038061)2.83788416
182granulocyte activation (GO:0036230)2.83004036
183positive regulation of macrophage differentiation (GO:0045651)2.82850158
184macrophage activation involved in immune response (GO:0002281)2.82132902
185Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80793750
186regulation of isotype switching to IgG isotypes (GO:0048302)2.80550218
187neutrophil activation (GO:0042119)2.79250517
188regulation of T-helper 1 cell differentiation (GO:0045625)2.79120072
189positive regulation of cAMP-mediated signaling (GO:0043950)2.79026984
190response to interferon-gamma (GO:0034341)2.78787185
191positive regulation of isotype switching (GO:0045830)2.77707862
192regulation of B cell differentiation (GO:0045577)2.77179301
193response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74892796
194response to host immune response (GO:0052572)2.74892796
195response to muramyl dipeptide (GO:0032495)2.74879544
196B cell receptor signaling pathway (GO:0050853)2.73582741
197lymphocyte chemotaxis (GO:0048247)2.73464834
198positive regulation of defense response to virus by host (GO:0002230)2.73262710
199natural killer cell differentiation (GO:0001779)2.72907897
200positive regulation of interleukin-2 production (GO:0032743)2.71284755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.27121064
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.86825561
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.80356575
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.62907646
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.49960414
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.33536744
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.15516255
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.15417943
9BP1_19119308_ChIP-ChIP_Hs578T_Human4.91917926
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.74394911
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.20552731
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.17228035
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.11039577
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80106954
15IRF8_27001747_Chip-Seq_BMDM_Mouse3.51747795
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44315248
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.29536337
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22456101
19STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11706431
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06424467
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03467032
22SCL_19346495_ChIP-Seq_HPC-7_Human2.86569162
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81486733
24RUNX_20019798_ChIP-Seq_JUKART_Human2.41369263
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36860390
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.32584635
27MYB_26560356_Chip-Seq_TH2_Human2.30507134
28GATA1_22025678_ChIP-Seq_K562_Human2.27201736
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22640057
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14511920
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12606997
32SPI1_23547873_ChIP-Seq_NB4_Human2.11697382
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11693660
34* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05756397
35HNF4A_19822575_ChIP-Seq_HepG2_Human2.02467501
36MYB_26560356_Chip-Seq_TH1_Human1.99999086
37MAF_26560356_Chip-Seq_TH1_Human1.98439982
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96081044
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88195536
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.87573657
41HTT_18923047_ChIP-ChIP_STHdh_Human1.84992292
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83165876
43E2F7_22180533_ChIP-Seq_HELA_Human1.79133711
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75338429
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.69253073
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68970638
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68812844
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65634251
49PU_27001747_Chip-Seq_BMDM_Mouse1.61849435
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61660617
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.60487062
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52586080
53VDR_24763502_ChIP-Seq_THP-1_Human1.52485094
54GATA3_27048872_Chip-Seq_THYMUS_Human1.48051842
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45969509
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45964143
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42097369
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.40947441
59UTX_26944678_Chip-Seq_JUKART_Human1.40257084
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38920052
61SPI1_23127762_ChIP-Seq_K562_Human1.38031899
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35757287
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34675979
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34627927
65GATA3_26560356_Chip-Seq_TH2_Human1.32139873
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.31843024
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30642184
68MYC_22102868_ChIP-Seq_BL_Human1.29890223
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29408776
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28185600
71VDR_21846776_ChIP-Seq_THP-1_Human1.26940451
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26888450
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23313963
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21893860
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21208480
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16986135
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15077356
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14845256
79MAF_26560356_Chip-Seq_TH2_Human1.13182318
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.12631681
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12551954
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.11562380
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10407424
84TCF7_22412390_ChIP-Seq_EML_Mouse1.10079352
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10034093
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09708276
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09017470
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07943063
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06941569
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03626730
91VDR_24787735_ChIP-Seq_THP-1_Human1.03541506
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00864747
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00648155
94* HNFA_21074721_ChIP-Seq_CACO-2_Human1.00316678
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00143588
96* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98527889
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97502386
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96723601
99AR_20517297_ChIP-Seq_VCAP_Human0.96238516
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93803187
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.92661728
102* PHF8_20622853_ChIP-Seq_HELA_Human0.92097960
103* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91853248
104EZH2_27294783_Chip-Seq_NPCs_Mouse0.90879662
105CEBPB_22108803_ChIP-Seq_LS180_Human0.90635032
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90118286
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88480240
108IRF1_19129219_ChIP-ChIP_H3396_Human0.88438719
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86408346
110CBP_21632823_ChIP-Seq_H3396_Human0.85592045
111* GATA6_21074721_ChIP-Seq_CACO-2_Human0.84929196
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83759528
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83586036
114GATA4_25053715_ChIP-Seq_YYC3_Human0.83585462
115NFYA_21822215_ChIP-Seq_K562_Human0.83563906
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82315430
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82282992
118SOX2_21211035_ChIP-Seq_LN229_Human0.81105344
119BCAT_22108803_ChIP-Seq_LS180_Human0.80684563
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80241044
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77885272
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.77695111
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.77161728
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.76527509
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76035815
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75004108
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74128020
128GATA2_19941826_ChIP-Seq_K562_Human0.73834779
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.73226320
130ELK1_19687146_ChIP-ChIP_HELA_Human0.72521276
131* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71945059
132GATA1_19941826_ChIP-Seq_K562_Human0.71837206
133ER_23166858_ChIP-Seq_MCF-7_Human0.71496720
134* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71181647
135SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70451508
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.70107174
137ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69499927
138* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68619779
139ETV1_20927104_ChIP-Seq_GIST48_Human0.68444453
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.68231822
141SMAD1_18555785_Chip-Seq_ESCs_Mouse0.68162184
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.68000486
143TP53_18474530_ChIP-ChIP_U2OS_Human0.67958190
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67476612
145ERG_20517297_ChIP-Seq_VCAP_Human0.66541337
146PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66341163
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65880554
148EGR1_19032775_ChIP-ChIP_M12_Human0.65859597
149RAC3_21632823_ChIP-Seq_H3396_Human0.65814558
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64947776
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.64926416
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.64644198
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64215998
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.64193227
155TAF2_19829295_ChIP-Seq_ESCs_Human0.63542949
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63236387
157RUNX1_27457419_Chip-Seq_LIVER_Mouse0.63050864
158NCOR1_26117541_ChIP-Seq_K562_Human0.62661253
159PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62001543
160FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.60920173
161FOXA1_21572438_ChIP-Seq_LNCaP_Human0.60759828
162ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60574587
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.60533400
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60289665
165SPI1_20517297_ChIP-Seq_HL60_Human0.60039958
166NFYB_21822215_ChIP-Seq_K562_Human0.60038993
167ESRRB_18555785_Chip-Seq_ESCs_Mouse0.59541413
168GATA6_25053715_ChIP-Seq_YYC3_Human0.59394337
169KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.58948342
170* P53_21459846_ChIP-Seq_SAOS-2_Human0.58788564
171EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.58164942
172PU1_27457419_Chip-Seq_LIVER_Mouse0.58071599
173SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57632659
174SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57632659
175CDX2_22108803_ChIP-Seq_LS180_Human0.56353615
176KLF5_20875108_ChIP-Seq_MESCs_Mouse0.56187166
177PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.55869089
178ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.55812283
179* RBPJ_21746931_ChIP-Seq_IB4_Human0.55761777
180MYC_19829295_ChIP-Seq_ESCs_Human0.55579417
181SOX2_20726797_ChIP-Seq_SW620_Human0.55229109
182FOXA1_27270436_Chip-Seq_PROSTATE_Human0.54723918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.75626555
2MP0005085_abnormal_gallbladder_physiolo6.13290207
3MP0005365_abnormal_bile_salt5.74893421
4MP0005360_urolithiasis5.70417507
5MP0008875_abnormal_xenobiotic_pharmacok5.47429980
6MP0003195_calcinosis5.02797795
7MP0001835_abnormal_antigen_presentation4.63297905
8MP0003252_abnormal_bile_duct4.02978914
9MP0009785_altered_susceptibility_to3.98574552
10MP0003724_increased_susceptibility_to3.72035914
11MP0003868_abnormal_feces_composition3.59339745
12MP0005671_abnormal_response_to3.53099270
13MP0001666_abnormal_nutrient_absorption3.29398655
14MP0002148_abnormal_hypersensitivity_rea3.09466985
15MP0005025_abnormal_response_to3.01368027
16MP0009697_abnormal_copulation2.99437905
17MP0003436_decreased_susceptibility_to2.94599521
18MP0000685_abnormal_immune_system2.94393692
19MP0005000_abnormal_immune_tolerance2.93850291
20MP0001800_abnormal_humoral_immune2.85345835
21MP0003806_abnormal_nucleotide_metabolis2.77401752
22MP0005387_immune_system_phenotype2.76159791
23MP0001790_abnormal_immune_system2.76159791
24MP0006082_CNS_inflammation2.70902799
25MP0002452_abnormal_antigen_presenting2.67011771
26MP0002723_abnormal_immune_serum2.65390105
27MP0002419_abnormal_innate_immunity2.64293022
28MP0010329_abnormal_lipoprotein_level2.60686732
29MP0001819_abnormal_immune_cell2.45813524
30MP0002420_abnormal_adaptive_immunity2.44265804
31MP0003763_abnormal_thymus_physiology2.33377334
32MP0002876_abnormal_thyroid_physiology2.31102148
33MP0005464_abnormal_platelet_physiology2.22599290
34MP0002166_altered_tumor_susceptibility2.21148234
35MP0002006_tumorigenesis2.19401347
36MP0005332_abnormal_amino_acid2.17507757
37MP0003303_peritoneal_inflammation2.08703649
38MP0002398_abnormal_bone_marrow2.08023116
39MP0001853_heart_inflammation2.06184860
40MP0009840_abnormal_foam_cell2.05778317
41MP0010155_abnormal_intestine_physiology1.99244943
42MP0000716_abnormal_immune_system1.96264555
43MP0005397_hematopoietic_system_phenotyp1.91847672
44MP0001545_abnormal_hematopoietic_system1.91847672
45MP0004510_myositis1.88112356
46MP0001845_abnormal_inflammatory_respons1.85160252
47MP0002405_respiratory_system_inflammati1.84958695
48MP0002396_abnormal_hematopoietic_system1.82628544
49MP0004947_skin_inflammation1.82138289
50MP0004808_abnormal_hematopoietic_stem1.78355931
51MP0009764_decreased_sensitivity_to1.75568724
52MP0001764_abnormal_homeostasis1.70413616
53MP0000689_abnormal_spleen_morphology1.68790111
54MP0009333_abnormal_splenocyte_physiolog1.67536050
55MP0008469_abnormal_protein_level1.66267910
56MP0001533_abnormal_skeleton_physiology1.64973436
57MP0002429_abnormal_blood_cell1.63260603
58MP0003300_gastrointestinal_ulcer1.63108243
59MP0002722_abnormal_immune_system1.62461980
60MP0002118_abnormal_lipid_homeostasis1.62259383
61MP0003448_altered_tumor_morphology1.60854293
62MP0009278_abnormal_bone_marrow1.43146351
63MP0000343_altered_response_to1.42612824
64MP0005058_abnormal_lysosome_morphology1.36700742
65MP0000703_abnormal_thymus_morphology1.27468484
66MP0000858_altered_metastatic_potential1.24737514
67MP0004019_abnormal_vitamin_homeostasis1.22079926
68MP0003191_abnormal_cellular_cholesterol1.20633254
69MP0001873_stomach_inflammation1.19653209
70MP0000465_gastrointestinal_hemorrhage1.19016457
71MP0004782_abnormal_surfactant_physiolog1.17669063
72MP0005310_abnormal_salivary_gland1.15150725
73MP0009763_increased_sensitivity_to1.14948389
74MP0005408_hypopigmentation1.14261122
75MP0003866_abnormal_defecation1.14110277
76MP0002998_abnormal_bone_remodeling1.13201614
77MP0001661_extended_life_span1.13105405
78MP0003828_pulmonary_edema1.12443374
79MP0003075_altered_response_to1.11251352
80MP0010307_abnormal_tumor_latency1.09552772
81MP0005584_abnormal_enzyme/coenzyme_acti1.08526275
82MP0005174_abnormal_tail_pigmentation1.06336296
83MP0001851_eye_inflammation1.04358433
84MP0003943_abnormal_hepatobiliary_system1.01883301
85MP0005451_abnormal_body_composition1.01446791
86MP0005166_decreased_susceptibility_to1.01374215
87MP0003186_abnormal_redox_activity1.00822182
88MP0000604_amyloidosis1.00029720
89MP0009053_abnormal_anal_canal0.98321520
90MP0006054_spinal_hemorrhage0.97144948
91MP0009643_abnormal_urine_homeostasis0.97120050
92MP0001879_abnormal_lymphatic_vessel0.89031806
93MP0000490_abnormal_crypts_of0.87833189
94MP0005376_homeostasis/metabolism_phenot0.84629611
95MP0002138_abnormal_hepatobiliary_system0.83896368
96MP0005167_abnormal_blood-brain_barrier0.83281959
97MP0000249_abnormal_blood_vessel0.83159648
98MP0005164_abnormal_response_to0.82690028
99MP0009642_abnormal_blood_homeostasis0.82189144
100MP0005390_skeleton_phenotype0.77126330
101MP0002933_joint_inflammation0.76420391
102MP0005075_abnormal_melanosome_morpholog0.75210844
103MP0003091_abnormal_cell_migration0.71724047
104MP0002019_abnormal_tumor_incidence0.71402663
105MP0005535_abnormal_body_temperature0.71359510
106MP0005395_other_phenotype0.71006540
107MP0002168_other_aberrant_phenotype0.70678459
108MP0009765_abnormal_xenobiotic_induced0.70359488
109MP0005636_abnormal_mineral_homeostasis0.69972167
110MP0003172_abnormal_lysosome_physiology0.69820034
111MP0008872_abnormal_physiological_respon0.69284236
112MP0003566_abnormal_cell_adhesion0.69106489
113MP0010352_gastrointestinal_tract_polyps0.68614326
114MP0003045_fibrosis0.67935521
115MP0002877_abnormal_melanocyte_morpholog0.67676776
116MP0000015_abnormal_ear_pigmentation0.65406403
117MP0003638_abnormal_response/metabolism_0.65222139
118MP0005266_abnormal_metabolism0.64458326
119MP0000569_abnormal_digit_pigmentation0.63795748
120MP0003011_delayed_dark_adaptation0.63537507
121MP0002136_abnormal_kidney_physiology0.63397502
122MP0005187_abnormal_penis_morphology0.62491604
123MP0010368_abnormal_lymphatic_system0.61260810
124MP0008874_decreased_physiological_sensi0.60429927
125MP0002095_abnormal_skin_pigmentation0.60289447
126MP0003279_aneurysm0.59538799
127MP0003879_abnormal_hair_cell0.58898311
128MP0002971_abnormal_brown_adipose0.58095403
129MP0001915_intracranial_hemorrhage0.58091510
130MP0000609_abnormal_liver_physiology0.57515838
131MP0000371_diluted_coat_color0.57295479
132MP0000598_abnormal_liver_morphology0.57090066
133MP0003656_abnormal_erythrocyte_physiolo0.56822510
134MP0002282_abnormal_trachea_morphology0.56746105
135MP0005023_abnormal_wound_healing0.55866126
136MP0003690_abnormal_glial_cell0.55702306
137MP0002132_abnormal_respiratory_system0.54359130
138MP0005319_abnormal_enzyme/_coenzyme0.54267739
139MP0003453_abnormal_keratinocyte_physiol0.53740628
140MP0002277_abnormal_respiratory_mucosa0.52966055
141MP0002078_abnormal_glucose_homeostasis0.51712072
142MP0005670_abnormal_white_adipose0.50773653
143MP0005334_abnormal_fat_pad0.48358211
144MP0004883_abnormal_blood_vessel0.45953345
145MP0006036_abnormal_mitochondrial_physio0.44965863
146MP0005448_abnormal_energy_balance0.34131535
147MP0008873_increased_physiological_sensi0.32865409
148MP0005647_abnormal_sex_gland0.32567934
149MP0004130_abnormal_muscle_cell0.31703553
150MP0002332_abnormal_exercise_endurance0.30507689
151MP0003959_abnormal_lean_body0.25065415
152MP0005084_abnormal_gallbladder_morpholo0.23751259
153MP0000920_abnormal_myelination0.22155421
154MP0005220_abnormal_exocrine_pancreas0.22118214
155MP0003718_maternal_effect0.21806313
156MP0003953_abnormal_hormone_level0.21406939

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)9.04772578
2Complement deficiency (HP:0004431)8.33567862
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.66661747
4Hypobetalipoproteinemia (HP:0003563)7.52684113
5Conjugated hyperbilirubinemia (HP:0002908)6.76137124
6Abnormality of complement system (HP:0005339)6.70405038
7Hyperlipoproteinemia (HP:0010980)5.42254184
8Eczematoid dermatitis (HP:0000976)5.32014025
9Intrahepatic cholestasis (HP:0001406)5.31639830
10Recurrent abscess formation (HP:0002722)5.23270915
11Abnormality of pyrimidine metabolism (HP:0004353)4.91261792
12Glomerulonephritis (HP:0000099)4.84985045
13Recurrent bacterial skin infections (HP:0005406)4.77069206
14Abnormality of the common coagulation pathway (HP:0010990)4.73586636
15Elevated erythrocyte sedimentation rate (HP:0003565)4.72613468
16Xanthomatosis (HP:0000991)4.67413223
17Chronic otitis media (HP:0000389)4.34919575
18Autoimmune thrombocytopenia (HP:0001973)4.26687121
19Hypolipoproteinemia (HP:0010981)4.25549430
20Myositis (HP:0100614)4.17987430
21Recurrent bronchitis (HP:0002837)4.13484732
22Recurrent gram-negative bacterial infections (HP:0005420)3.94458241
23Recurrent viral infections (HP:0004429)3.89492256
24Mediastinal lymphadenopathy (HP:0100721)3.86583940
25Recurrent fungal infections (HP:0002841)3.83570465
26Abnormality of the intrinsic pathway (HP:0010989)3.79754308
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78452481
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74743683
29Generalized aminoaciduria (HP:0002909)3.74322821
30Fat malabsorption (HP:0002630)3.69254259
31Spontaneous abortion (HP:0005268)3.69135478
32Orchitis (HP:0100796)3.66042701
33Abnormality of T cell number (HP:0011839)3.63326429
34Nephritis (HP:0000123)3.58890542
35Vasculitis (HP:0002633)3.57859851
36Spontaneous hematomas (HP:0007420)3.56602359
37T lymphocytopenia (HP:0005403)3.54763733
38Optic neuritis (HP:0100653)3.54345594
39Retrobulbar optic neuritis (HP:0100654)3.54345594
40Abnormality of macrophages (HP:0004311)3.49229367
41Hyperglycinemia (HP:0002154)3.46921318
42Recurrent skin infections (HP:0001581)3.46165980
43Hyperammonemia (HP:0001987)3.43093637
44Cellulitis (HP:0100658)3.42771343
45Abnormality of T cells (HP:0002843)3.35176100
46IgM deficiency (HP:0002850)3.32732237
47Autoimmune hemolytic anemia (HP:0001890)3.32160911
48Increased IgM level (HP:0003496)3.29871296
49Recurrent cutaneous fungal infections (HP:0011370)3.26259728
50Chronic mucocutaneous candidiasis (HP:0002728)3.26259728
51Rickets (HP:0002748)3.25861864
52Steatorrhea (HP:0002570)3.18711332
53Thrombocytosis (HP:0001894)3.17767039
54Agammaglobulinemia (HP:0004432)3.16656269
55Petechiae (HP:0000967)3.14046910
56Meningitis (HP:0001287)3.13057052
57Stomatitis (HP:0010280)3.07787000
58Abnormality of T cell physiology (HP:0011840)3.05880783
59Abnormality of the nasal mucosa (HP:0000433)3.05710081
60Abnormality of serine family amino acid metabolism (HP:0010894)3.05047658
61Abnormality of glycine metabolism (HP:0010895)3.05047658
62Osteomalacia (HP:0002749)3.03506999
63Prostate neoplasm (HP:0100787)3.03121230
64Systemic lupus erythematosus (HP:0002725)3.00399238
65Vacuolated lymphocytes (HP:0001922)2.99665198
66Prolonged bleeding time (HP:0003010)2.95497357
67Delayed CNS myelination (HP:0002188)2.94748778
68Reduced antithrombin III activity (HP:0001976)2.94688278
69Arterial thrombosis (HP:0004420)2.92493729
70Gingival bleeding (HP:0000225)2.92279884
71Nasal polyposis (HP:0100582)2.91586538
72Basal ganglia calcification (HP:0002135)2.90534500
73Periodontitis (HP:0000704)2.88007505
74Abnormality of the prostate (HP:0008775)2.87523512
75Abnormality of methionine metabolism (HP:0010901)2.87239361
76Hyperglycinuria (HP:0003108)2.84986756
77Thyroiditis (HP:0100646)2.80537637
78Hypercholesterolemia (HP:0003124)2.79455893
79Hemoptysis (HP:0002105)2.79209536
80Epistaxis (HP:0000421)2.77552841
81Vascular calcification (HP:0004934)2.76318015
82Gingivitis (HP:0000230)2.74300289
83Gastrointestinal infarctions (HP:0005244)2.74053359
84Obstructive lung disease (HP:0006536)2.73285017
85Chronic obstructive pulmonary disease (HP:0006510)2.73285017
86Pulmonary infiltrates (HP:0002113)2.72617459
87Hypergammaglobulinemia (HP:0010702)2.72408087
88Interstitial pulmonary disease (HP:0006530)2.72370571
89Abnormality of nucleobase metabolism (HP:0010932)2.71889779
90Pustule (HP:0200039)2.69594621
91Abnormality of serum amino acid levels (HP:0003112)2.69274080
92IgG deficiency (HP:0004315)2.68754849
93Abnormal delayed hypersensitivity skin test (HP:0002963)2.68685461
94Leukocytosis (HP:0001974)2.67146281
95Hyperbilirubinemia (HP:0002904)2.66362591
96Chronic diarrhea (HP:0002028)2.66070161
97Hypoalphalipoproteinemia (HP:0003233)2.63728136
98Keratoconjunctivitis sicca (HP:0001097)2.62629913
99Fair hair (HP:0002286)2.62303576
100Mitral stenosis (HP:0001718)2.60549013
101Hemorrhage of the eye (HP:0011885)2.58084518
102IgA deficiency (HP:0002720)2.57027380
103Epidermoid cyst (HP:0200040)2.56629216
104Hematochezia (HP:0002573)2.54913137
105Inflammation of the large intestine (HP:0002037)2.53202376
106Lymphopenia (HP:0001888)2.52546223
107Purpura (HP:0000979)2.50425774
108Hyperphosphaturia (HP:0003109)2.47726691
109Eosinophilia (HP:0001880)2.47371923
110Abnormality of eosinophils (HP:0001879)2.46503911
111Abnormality of cells of the lymphoid lineage (HP:0012140)2.46157582
112Joint hemorrhage (HP:0005261)2.45195671
113Osteomyelitis (HP:0002754)2.44194718
114Severe combined immunodeficiency (HP:0004430)2.43385517
115Colitis (HP:0002583)2.42787066
116Cardiovascular calcification (HP:0011915)2.42769557
117Combined immunodeficiency (HP:0005387)2.42298712
118Abnormality of the fingertips (HP:0001211)2.42071314
119Thrombophlebitis (HP:0004418)2.40576397
120Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39662564
121Recurrent pneumonia (HP:0006532)2.38231755
122Menorrhagia (HP:0000132)2.37764456
123Chronic sinusitis (HP:0011109)2.37688005
124Keratoconjunctivitis (HP:0001096)2.37579492
125Gastrointestinal inflammation (HP:0004386)2.36916659
126Abnormality of B cell number (HP:0010975)2.34994072
127B lymphocytopenia (HP:0010976)2.34994072
128Hypoplasia of the thymus (HP:0000778)2.33254852
129Granulocytopenia (HP:0001913)2.32585545
130Glycosuria (HP:0003076)2.30035010
131Abnormality of urine glucose concentration (HP:0011016)2.30035010
132Increased neuronal autofluorescent lipopigment (HP:0002074)2.27993981
133Abnormal gallbladder physiology (HP:0012438)2.27204722
134Cholecystitis (HP:0001082)2.27204722
135Encephalitis (HP:0002383)2.26719822
136Metabolic acidosis (HP:0001942)2.26433399
137Abnormality of vitamin metabolism (HP:0100508)2.26287858
138Joint swelling (HP:0001386)2.26257203
139Chest pain (HP:0100749)2.25928227
140Pulmonary embolism (HP:0002204)2.23509631
141Arthropathy (HP:0003040)2.22983764
142Ketosis (HP:0001946)2.22243841
143Hypochromic microcytic anemia (HP:0004840)2.21533173
144Recurrent lower respiratory tract infections (HP:0002783)2.20748596
145Bronchitis (HP:0012387)2.20474880
146Panhypogammaglobulinemia (HP:0003139)2.18469961
147Increased cerebral lipofuscin (HP:0011813)2.17384773
148Hepatocellular carcinoma (HP:0001402)2.16489943
149Thick nail (HP:0001805)2.16110969
150Irritability (HP:0000737)2.14469172
151Increased IgE level (HP:0003212)2.14371028
152Tetraparesis (HP:0002273)2.14018540
153Gastrointestinal stroma tumor (HP:0100723)2.13626411
154Urticaria (HP:0001025)2.08585458
155Neonatal hypoglycemia (HP:0001998)2.07868513
156Skin ulcer (HP:0200042)2.06864140
157Gangrene (HP:0100758)2.05128641
158Sepsis (HP:0100806)2.04258110
159Elevated alkaline phosphatase (HP:0003155)2.03983510
160Increased serum ferritin (HP:0003281)2.03868365
161Cholelithiasis (HP:0001081)2.03434160
162Myocardial infarction (HP:0001658)2.02363753
163Abnormality of monocarboxylic acid metabolism (HP:0010996)10.4981057
164Deep venous thrombosis (HP:0002625)10.2505583
165Abnormality of sulfur amino acid metabolism (HP:0004339)1.99236804
166Abnormality of iron homeostasis (HP:0011031)1.97237113
167Abnormal enzyme/coenzyme activity (HP:0012379)1.94672461
168Increased mean platelet volume (HP:0011877)1.94103153
169Abnormal urine phosphate concentration (HP:0012599)1.93894224
170Abnormal gallbladder morphology (HP:0012437)1.93111667
171Abnormality of the Achilles tendon (HP:0005109)1.89900445
172Hypophosphatemic rickets (HP:0004912)1.89744311
173Abnormality of alkaline phosphatase activity (HP:0004379)1.87517661
174Abnormality of transition element cation homeostasis (HP:0011030)1.84549802
175Abnormal biliary tract physiology (HP:0012439)1.83876382
176Bile duct proliferation (HP:0001408)1.83876382
177Generalized hypopigmentation of hair (HP:0011358)1.83564313
178Bifid scrotum (HP:0000048)1.81658294
179Poikilocytosis (HP:0004447)1.80757061
180Lethargy (HP:0001254)1.80116314
181Abnormal platelet volume (HP:0011876)1.77403155
182Alkalosis (HP:0001948)1.75997879
183Hypochromic anemia (HP:0001931)1.75098415
184Pancreatitis (HP:0001733)1.75076525
185Hydroxyprolinuria (HP:0003080)1.73558293
186Abnormality of proline metabolism (HP:0010907)1.73558293
187Abnormality of purine metabolism (HP:0004352)1.71344273
188Cerebral edema (HP:0002181)1.70776670
189Anorexia (HP:0002039)1.65852323
190Atrioventricular block (HP:0001678)1.62205832
191Abnormal platelet function (HP:0011869)1.61105845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.73237218
2TXK3.60288285
3MAP4K13.57764811
4BCKDK3.50150169
5TYK23.45326484
6IKBKE3.29812133
7JAK33.19175347
8TBK12.92811513
9IRAK42.63175781
10KIT2.63019297
11FGFR42.53932201
12JAK12.37621122
13BLK2.27109131
14PIK3CA2.23213251
15TEC2.14255999
16FGFR32.09291800
17ZAP701.98627877
18PRKACG1.94337177
19IKBKB1.91646142
20MAPKAPK31.82733478
21BTK1.80920888
22IRAK31.72714606
23PRPF4B1.70722714
24SIK11.67201663
25PIM21.66373430
26MAP3K131.59959059
27TGFBR21.55733506
28NEK91.54872427
29NME21.53411251
30PBK1.53004201
31ITK1.52758897
32RIPK41.51796601
33SYK1.51465481
34TIE11.44127915
35CHUK1.42744715
36MAP3K31.40555156
37LCK1.35377998
38GRK11.34561615
39TGFBR11.34196667
40STK101.32523196
41NLK1.32185918
42CSK1.30926145
43RPS6KA41.30860326
44PRKCG1.30792737
45RIPK11.30589252
46PRKAA21.25039311
47ERN11.24904091
48SCYL21.23427476
49EIF2AK11.22178296
50HCK1.21291980
51TAOK31.20738791
52PIM11.19972009
53TAOK21.19532209
54EPHB11.18575736
55CDK81.17819114
56MST41.14497464
57CAMKK21.13056142
58LYN1.11421572
59CSF1R1.11314603
60MAP2K31.09545273
61MAP2K41.06926425
62EIF2AK31.05666847
63JAK21.05306704
64KDR1.05054312
65DAPK21.03301769
66EPHA31.03036193
67SIK30.94917630
68CLK10.93582397
69PINK10.91597434
70STK40.90867488
71IRAK10.88913765
72FES0.87477771
73MAP3K110.86272576
74MARK30.83468504
75PRKG10.81351067
76EIF2AK20.80675598
77MATK0.80246015
78TRIB30.75991802
79FLT30.73767060
80BMPR20.72960901
81NTRK30.71902585
82PRKCZ0.71364099
83PRKACA0.70268566
84PDPK10.69212094
85CSNK1D0.68892345
86TRPM70.67383216
87PRKCB0.66658523
88LRRK20.66005818
89TNK20.65874966
90PRKCA0.65463118
91MAP3K100.65320148
92TESK20.65271732
93MAP3K120.64632013
94BCR0.64283308
95MAPK110.64174691
96MUSK0.63968828
97PRKCQ0.63111733
98EEF2K0.62491620
99MST1R0.61625281
100PKN20.60927074
101BMPR1B0.60508287
102DAPK10.59907705
103NUAK10.53503807
104PRKAA10.53202688
105MAPK70.51225621
106INSRR0.48830365
107BRD40.47330293
108ABL10.46692871
109CDK60.46027739
110MAP3K20.45929131
111ERBB20.44935165
112BRSK20.44925577
113PRKCD0.43909844
114RPS6KA50.43315914
115MAP3K60.43070051
116PDK20.41983519
117MAP3K50.41926505
118HIPK20.40169335
119SRC0.37621414
120GRK70.36310912
121FER0.36216161
122GRK60.36135929
123RPS6KA30.35534154
124GSK3A0.34982733
125EGFR0.34894026
126SMG10.34605841
127BMX0.33347090
128ADRBK20.32991315
129MAPK40.32977729
130MAPKAPK20.31576928
131RPS6KA60.31556075
132MYLK0.30390711
133IGF1R0.29610896
134IRAK20.29396462
135PRKCH0.29210574
136ACVR1B0.28725364
137SIK20.27779509
138FRK0.27508868
139PDK10.27493682
140CDK40.26065302
141ABL20.23798918
142ATR0.23621523
143CDK90.23552658
144MAPK30.21705913
145PIK3CG0.19835679
146MAPK120.18337379

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39748034
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.79187794
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.61352935
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.47025070
5Retinol metabolism_Homo sapiens_hsa008303.45609577
6Leishmaniasis_Homo sapiens_hsa051403.03651246
7Primary immunodeficiency_Homo sapiens_hsa053403.03534593
8Chemical carcinogenesis_Homo sapiens_hsa052042.98043446
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.96014333
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.95460284
11Graft-versus-host disease_Homo sapiens_hsa053322.94128267
12Measles_Homo sapiens_hsa051622.86077929
13Allograft rejection_Homo sapiens_hsa053302.81693744
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.76885906
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.76120665
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.75005136
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67605234
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.62682508
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.61904741
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61657590
21Intestinal immune network for IgA production_Homo sapiens_hsa046722.57740561
22Fatty acid degradation_Homo sapiens_hsa000712.42296246
23Staphylococcus aureus infection_Homo sapiens_hsa051502.42151329
24Arginine biosynthesis_Homo sapiens_hsa002202.30680975
25Phenylalanine metabolism_Homo sapiens_hsa003602.26273442
26Butanoate metabolism_Homo sapiens_hsa006502.21955151
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13159961
28Osteoclast differentiation_Homo sapiens_hsa043802.12332483
29NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11424698
30Herpes simplex infection_Homo sapiens_hsa051682.10112069
31Tyrosine metabolism_Homo sapiens_hsa003502.09094630
32Legionellosis_Homo sapiens_hsa051342.08303250
33Malaria_Homo sapiens_hsa051442.06838388
34Influenza A_Homo sapiens_hsa051642.02884332
35Tryptophan metabolism_Homo sapiens_hsa003801.97896199
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.94355273
37Pertussis_Homo sapiens_hsa051331.92637664
38Antigen processing and presentation_Homo sapiens_hsa046121.89231501
39Linoleic acid metabolism_Homo sapiens_hsa005911.87664850
40Hematopoietic cell lineage_Homo sapiens_hsa046401.84824757
41Histidine metabolism_Homo sapiens_hsa003401.84484679
42Caffeine metabolism_Homo sapiens_hsa002321.82405367
43Bile secretion_Homo sapiens_hsa049761.80725568
44TNF signaling pathway_Homo sapiens_hsa046681.75323392
45Toxoplasmosis_Homo sapiens_hsa051451.70792697
46Type I diabetes mellitus_Homo sapiens_hsa049401.70581052
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67611271
48Asthma_Homo sapiens_hsa053101.67049114
49B cell receptor signaling pathway_Homo sapiens_hsa046621.65623442
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61055145
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58861769
52Starch and sucrose metabolism_Homo sapiens_hsa005001.55289536
53Tuberculosis_Homo sapiens_hsa051521.55271050
54Autoimmune thyroid disease_Homo sapiens_hsa053201.50953590
55African trypanosomiasis_Homo sapiens_hsa051431.50713192
56Viral myocarditis_Homo sapiens_hsa054161.46144953
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40767587
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37330930
59Rheumatoid arthritis_Homo sapiens_hsa053231.37214633
60PPAR signaling pathway_Homo sapiens_hsa033201.34303410
61beta-Alanine metabolism_Homo sapiens_hsa004101.31842349
62Chemokine signaling pathway_Homo sapiens_hsa040621.31338491
63Salmonella infection_Homo sapiens_hsa051321.30323833
64T cell receptor signaling pathway_Homo sapiens_hsa046601.29300686
65Apoptosis_Homo sapiens_hsa042101.27021262
66Hepatitis C_Homo sapiens_hsa051601.26880487
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24345193
68Cyanoamino acid metabolism_Homo sapiens_hsa004601.23360127
69Hepatitis B_Homo sapiens_hsa051611.22717566
70Shigellosis_Homo sapiens_hsa051311.21686073
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19715018
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19347695
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.18632390
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09731103
75Vitamin B6 metabolism_Homo sapiens_hsa007501.08979221
76Arachidonic acid metabolism_Homo sapiens_hsa005901.08065675
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05761809
78Leukocyte transendothelial migration_Homo sapiens_hsa046701.00452590
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98108303
80Pyruvate metabolism_Homo sapiens_hsa006200.92951271
81Acute myeloid leukemia_Homo sapiens_hsa052210.91094900
82Propanoate metabolism_Homo sapiens_hsa006400.89669247
83Biosynthesis of amino acids_Homo sapiens_hsa012300.88956602
84Arginine and proline metabolism_Homo sapiens_hsa003300.88742757
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86591789
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85250756
87Platelet activation_Homo sapiens_hsa046110.83720509
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82505591
89Other glycan degradation_Homo sapiens_hsa005110.82418843
90Fatty acid metabolism_Homo sapiens_hsa012120.80576546
91Complement and coagulation cascades_Homo sapiens_hsa046100.79441798
92Fat digestion and absorption_Homo sapiens_hsa049750.78189691
93Prolactin signaling pathway_Homo sapiens_hsa049170.77245237
94Carbon metabolism_Homo sapiens_hsa012000.76956648
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76790513
96Lysosome_Homo sapiens_hsa041420.75373302
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72191151
98Phagosome_Homo sapiens_hsa041450.70462373
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67180542
100One carbon pool by folate_Homo sapiens_hsa006700.65612070
101Pancreatic cancer_Homo sapiens_hsa052120.65376510
102Sulfur metabolism_Homo sapiens_hsa009200.63704546
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62287851
104Chronic myeloid leukemia_Homo sapiens_hsa052200.58166355
105Epstein-Barr virus infection_Homo sapiens_hsa051690.56987615
106Small cell lung cancer_Homo sapiens_hsa052220.56319579
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55840090
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54785980
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.53774467
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52094896
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.51670113
112Viral carcinogenesis_Homo sapiens_hsa052030.51634128
113HTLV-I infection_Homo sapiens_hsa051660.51281153
114Lysine degradation_Homo sapiens_hsa003100.51006114
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50878556
116Amoebiasis_Homo sapiens_hsa051460.48956786
117p53 signaling pathway_Homo sapiens_hsa041150.48102890
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.46787101
119HIF-1 signaling pathway_Homo sapiens_hsa040660.43906869
120ABC transporters_Homo sapiens_hsa020100.42515605
121Metabolic pathways_Homo sapiens_hsa011000.41304639
122Insulin resistance_Homo sapiens_hsa049310.38140705
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37693348
124Sulfur relay system_Homo sapiens_hsa041220.37623497
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35823432
126Notch signaling pathway_Homo sapiens_hsa043300.34459783
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33889204
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33447070
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31017253
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30704160
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28622569
132Prion diseases_Homo sapiens_hsa050200.27614537
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.26304785
134Glycerolipid metabolism_Homo sapiens_hsa005610.26279750
135Fatty acid elongation_Homo sapiens_hsa000620.26191935
136FoxO signaling pathway_Homo sapiens_hsa040680.23718864
137Ribosome_Homo sapiens_hsa030100.22264388
138Base excision repair_Homo sapiens_hsa034100.22103520
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19858406
140DNA replication_Homo sapiens_hsa030300.16468337
141Pentose phosphate pathway_Homo sapiens_hsa000300.16439168
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16269013
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.15277911
144Fructose and mannose metabolism_Homo sapiens_hsa000510.14983867
145Non-homologous end-joining_Homo sapiens_hsa034500.14614132
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13592791
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13060972
148Peroxisome_Homo sapiens_hsa041460.11531523
149Systemic lupus erythematosus_Homo sapiens_hsa053220.10148805
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10044306
151VEGF signaling pathway_Homo sapiens_hsa043700.09978322
152Homologous recombination_Homo sapiens_hsa034400.08353812
153Prostate cancer_Homo sapiens_hsa052150.07744882
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07458703
155Protein export_Homo sapiens_hsa030600.07192150
156Steroid biosynthesis_Homo sapiens_hsa001000.07008767
157MicroRNAs in cancer_Homo sapiens_hsa052060.06845305
158Selenocompound metabolism_Homo sapiens_hsa004500.05850646
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05419019
160Glutathione metabolism_Homo sapiens_hsa004800.03042992
161Glucagon signaling pathway_Homo sapiens_hsa049220.02809696
162Vitamin digestion and absorption_Homo sapiens_hsa049770.02219178
163Sphingolipid metabolism_Homo sapiens_hsa00600-0.2093551
164Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1947043
165Type II diabetes mellitus_Homo sapiens_hsa04930-0.1738810
166AMPK signaling pathway_Homo sapiens_hsa04152-0.1519497
167Nitrogen metabolism_Homo sapiens_hsa00910-0.1306335
168Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1244783
169Mineral absorption_Homo sapiens_hsa04978-0.1064704
170Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1034966
171Folate biosynthesis_Homo sapiens_hsa00790-0.0634705
172Renin-angiotensin system_Homo sapiens_hsa04614-0.0627608
173Galactose metabolism_Homo sapiens_hsa00052-0.0580961
174Serotonergic synapse_Homo sapiens_hsa04726-0.0467533
175Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0202816

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