GBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.79632715
2cellular response to pH (GO:0071467)8.86616416
3virion assembly (GO:0019068)8.01412155
4male sex determination (GO:0030238)7.34708206
5regulation of NFAT protein import into nucleus (GO:0051532)7.24631717
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.12458920
7negative regulation of cell size (GO:0045792)6.73750069
8negative regulation of synaptic transmission, glutamatergic (GO:0051967)6.67322970
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.33083942
10muscle filament sliding (GO:0030049)6.28396442
11actin-myosin filament sliding (GO:0033275)6.28396442
12skeletal muscle contraction (GO:0003009)6.11530426
13behavioral response to nicotine (GO:0035095)6.00447482
14regulation of synapse structural plasticity (GO:0051823)5.92154509
15sarcoplasmic reticulum calcium ion transport (GO:0070296)5.77017523
16sequestering of actin monomers (GO:0042989)5.62739041
17regulation of acrosome reaction (GO:0060046)5.60715780
18negative regulation of myotube differentiation (GO:0010832)5.51960164
19pyrimidine nucleobase catabolic process (GO:0006208)5.27247903
20response to muscle activity (GO:0014850)5.16321221
21intracellular transport of virus (GO:0075733)5.05869427
22multi-organism transport (GO:0044766)5.05869427
23multi-organism localization (GO:1902579)5.05869427
24multi-organism intracellular transport (GO:1902583)5.05869427
25transport of virus (GO:0046794)5.05869427
26positive regulation of protein homooligomerization (GO:0032464)5.00713173
27actin-mediated cell contraction (GO:0070252)5.00504594
28regulation of glutamate receptor signaling pathway (GO:1900449)4.85003439
29cell migration in hindbrain (GO:0021535)4.75954394
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.71237708
31cellular response to ATP (GO:0071318)4.67628593
32negative regulation of cell aging (GO:0090344)4.66345946
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.59706880
34synaptic transmission, glutamatergic (GO:0035249)4.59278300
35meiotic chromosome segregation (GO:0045132)4.54708206
36cell proliferation in forebrain (GO:0021846)4.48491711
37response to pH (GO:0009268)4.45769004
38skeletal muscle fiber development (GO:0048741)4.41472746
39positive regulation of response to oxidative stress (GO:1902884)4.40750639
40positive regulation of cellular response to oxidative stress (GO:1900409)4.40750639
41regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.38094389
42male meiosis I (GO:0007141)4.35762711
43cerebellum development (GO:0021549)4.31404483
44synaptonemal complex assembly (GO:0007130)4.29215319
45sex determination (GO:0007530)4.26111712
46piRNA metabolic process (GO:0034587)4.10346076
47striated muscle contraction (GO:0006941)4.06284919
48detection of light stimulus involved in visual perception (GO:0050908)4.03093612
49detection of light stimulus involved in sensory perception (GO:0050962)4.03093612
50histone H4 deacetylation (GO:0070933)4.00427322
51synaptonemal complex organization (GO:0070193)4.00338548
52telencephalon development (GO:0021537)3.97150208
53axonal fasciculation (GO:0007413)3.96428804
54nucleobase catabolic process (GO:0046113)3.95205043
55NLS-bearing protein import into nucleus (GO:0006607)3.92748789
56neuromuscular synaptic transmission (GO:0007274)3.90588196
57muscle fiber development (GO:0048747)3.85442066
58regulation of relaxation of muscle (GO:1901077)3.85040991
59ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.83215052
60creatine metabolic process (GO:0006600)3.81612971
61response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.76435470
62synaptic vesicle maturation (GO:0016188)3.75214965
63peptidyl-arginine omega-N-methylation (GO:0035247)3.74466143
64regulation of cytokine production involved in inflammatory response (GO:1900015)3.73575440
65DNA damage response, detection of DNA damage (GO:0042769)3.72774649
66regulation of protein heterodimerization activity (GO:0043497)3.68873420
67myotube cell development (GO:0014904)3.65909126
68regulation of calcium ion-dependent exocytosis (GO:0017158)3.65129379
69post-embryonic morphogenesis (GO:0009886)3.64494152
70peptidyl-arginine methylation (GO:0018216)3.62583376
71peptidyl-arginine N-methylation (GO:0035246)3.62583376
72forebrain neuron development (GO:0021884)3.58177103
73sarcomere organization (GO:0045214)3.56355772
74neuron-neuron synaptic transmission (GO:0007270)3.55748050
75regulation of phospholipid biosynthetic process (GO:0071071)3.54081772
76DNA methylation involved in gamete generation (GO:0043046)3.53914632
77positive regulation of synapse maturation (GO:0090129)3.53276408
78glycogen catabolic process (GO:0005980)3.52242327
79synaptic transmission, cholinergic (GO:0007271)3.51315925
80myofibril assembly (GO:0030239)3.49596117
81positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.47391713
82mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.47391713
83neuronal action potential propagation (GO:0019227)3.46674672
84chromosome organization involved in meiosis (GO:0070192)3.45432595
85response to hepatocyte growth factor (GO:0035728)3.44749882
86cellular response to hepatocyte growth factor stimulus (GO:0035729)3.44749882
87regulation of early endosome to late endosome transport (GO:2000641)3.44136729
88protein carboxylation (GO:0018214)3.43979670
89peptidyl-glutamic acid carboxylation (GO:0017187)3.43979670
90multicellular organism reproduction (GO:0032504)3.42199236
91response to acidic pH (GO:0010447)3.41035223
92regulation of dopamine secretion (GO:0014059)3.40035304
93chromatin silencing (GO:0006342)3.39766534
94GDP-mannose metabolic process (GO:0019673)3.39658725
95retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39234134
96response to inactivity (GO:0014854)3.38037154
97DNA strand renaturation (GO:0000733)3.37908603
98actin filament-based movement (GO:0030048)3.37366313
99mannose metabolic process (GO:0006013)3.36727672
100spinal cord development (GO:0021510)3.36337199
101histone H3 deacetylation (GO:0070932)3.35504330
102transmission of nerve impulse (GO:0019226)3.34114811
103lens fiber cell differentiation (GO:0070306)3.32850456
104layer formation in cerebral cortex (GO:0021819)3.31254046
105snRNA transcription (GO:0009301)3.31031418
106embryonic retina morphogenesis in camera-type eye (GO:0060059)3.28241861
107muscle contraction (GO:0006936)3.27799576
108meiosis I (GO:0007127)3.27726116
109actin cytoskeleton reorganization (GO:0031532)3.27547462
110postsynaptic membrane organization (GO:0001941)3.25784331
111neuron recognition (GO:0008038)3.24145810
112glucan catabolic process (GO:0009251)3.23649161
113ribosomal small subunit biogenesis (GO:0042274)3.22516601
114stress granule assembly (GO:0034063)3.20904887
115negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20868204
116folic acid-containing compound biosynthetic process (GO:0009396)3.18282767
117regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17520377
118purine nucleotide salvage (GO:0032261)3.16884469
119histone arginine methylation (GO:0034969)3.11337023
120negative regulation of TOR signaling (GO:0032007)3.10462109
121mitotic cell cycle arrest (GO:0071850)3.09104866
122glutamate receptor signaling pathway (GO:0007215)3.07420715
123glycogen biosynthetic process (GO:0005978)3.06694955
124glucan biosynthetic process (GO:0009250)3.06694955
125negative regulation of microtubule polymerization (GO:0031115)3.06274227
126cellular response to virus (GO:0098586)3.03582243
127glycine transport (GO:0015816)3.02388881
128sulfur amino acid catabolic process (GO:0000098)3.02132708
129cellular polysaccharide catabolic process (GO:0044247)3.01529624
130plasma membrane repair (GO:0001778)2.99869992
131protein localization to synapse (GO:0035418)2.98582532
132adenosine receptor signaling pathway (GO:0001973)2.97244506
133rRNA methylation (GO:0031167)2.96828146
134thalamus development (GO:0021794)2.93531404
135negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91808527
136dendritic spine morphogenesis (GO:0060997)2.91706143
137pre-miRNA processing (GO:0031054)2.90590525
138modulation by virus of host process (GO:0019054)2.89651804
139negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88738442
140axon extension (GO:0048675)2.87040812
141coronary vasculature morphogenesis (GO:0060977)2.86876688
142rRNA modification (GO:0000154)2.85947669
143reciprocal meiotic recombination (GO:0007131)2.85630778
144reciprocal DNA recombination (GO:0035825)2.85630778
145grooming behavior (GO:0007625)2.85294359
146muscle system process (GO:0003012)2.84984629
147ear development (GO:0043583)2.84517757
148regulation of protein homooligomerization (GO:0032462)2.84443379
149neuron cell-cell adhesion (GO:0007158)2.84300404
150regulation of SMAD protein import into nucleus (GO:0060390)2.84021179
151synapsis (GO:0007129)2.83938909
152histone deacetylation (GO:0016575)2.83822140
153response to activity (GO:0014823)2.83791069
154epithelial cell maturation (GO:0002070)2.83125404
155regulation of synapse maturation (GO:0090128)2.82509550
156cardiac muscle contraction (GO:0060048)2.82115829
157AMP metabolic process (GO:0046033)2.81919840
158DNA replication checkpoint (GO:0000076)2.80905426
159negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.79956557
160positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79491495
161positive regulation of filopodium assembly (GO:0051491)2.79086870
162meiotic nuclear division (GO:0007126)2.78283037
163response to ATP (GO:0033198)2.78027244
164regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.77680200
165negative regulation of striated muscle cell differentiation (GO:0051154)2.77584607
166localization within membrane (GO:0051668)2.77320154
167establishment of mitochondrion localization (GO:0051654)2.77221060
168RNA localization (GO:0006403)2.76929336
169viral life cycle (GO:0019058)2.75087862
170negative regulation of potassium ion transmembrane transport (GO:1901380)2.74123452
171phosphatidylinositol 3-kinase signaling (GO:0014065)2.73641766
172skeletal muscle tissue regeneration (GO:0043403)2.73321453
173cranial nerve structural organization (GO:0021604)2.72952870
174generation of neurons (GO:0048699)2.72257688
175cochlea development (GO:0090102)2.71872314
176striated muscle cell development (GO:0055002)2.71857990
177regulation of hydrogen peroxide metabolic process (GO:0010310)2.69182703
178negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.68998209
179protein-DNA complex disassembly (GO:0032986)2.68137088
180nucleosome disassembly (GO:0006337)2.68137088
181cranial nerve morphogenesis (GO:0021602)2.67674793
182polysaccharide catabolic process (GO:0000272)2.66004415
183nucleotide salvage (GO:0043173)2.65803823
184positive regulation of axon extension (GO:0045773)2.65674705
185mitochondrion distribution (GO:0048311)2.65388199
186chaperone-mediated protein transport (GO:0072321)2.65183124
187osteoblast development (GO:0002076)2.63918799
188synaptic vesicle exocytosis (GO:0016079)2.63435724
189apoptotic process involved in development (GO:1902742)2.59844289
190pituitary gland development (GO:0021983)2.57729950
191neuron projection extension (GO:1990138)2.57155715
192glial cell proliferation (GO:0014009)2.55313068
193metanephric mesenchyme development (GO:0072075)2.55272334
194axon extension involved in axon guidance (GO:0048846)2.52975324
195neuron projection extension involved in neuron projection guidance (GO:1902284)2.52975324
196* spinal cord motor neuron differentiation (GO:0021522)2.51816312
197viral protein processing (GO:0019082)12.9309070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.99449404
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.36529785
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10301245
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31426967
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.18238051
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.95892570
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.85742034
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.77135378
9* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.65253557
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.55561842
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46333453
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43995312
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34865083
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.34720623
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25092535
16E2F1_20622854_ChIP-Seq_HELA_Human2.23060036
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17038941
18BCOR_27268052_Chip-Seq_Bcells_Human2.15049807
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.11467058
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.10875341
21PHF8_20622854_ChIP-Seq_HELA_Human2.08257903
22* EZH2_27304074_Chip-Seq_ESCs_Mouse2.03113478
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.02655627
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99884977
25* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99519442
26CTCF_27219007_Chip-Seq_ERYTHROID_Human1.98045184
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97595798
28SOX2_16153702_ChIP-ChIP_HESCs_Human1.91210778
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88948475
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88948475
31* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88538341
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.85523404
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85486713
34CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.84809060
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.84310769
36MAF_26560356_Chip-Seq_TH2_Human1.82379782
37* LXR_22292898_ChIP-Seq_THP-1_Human1.80553418
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79866728
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.79865955
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.78418974
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.75110583
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74078295
43* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73597632
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.70866462
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70498818
46* RARB_24833708_ChIP-Seq_LIVER_Mouse1.69735715
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69344798
48KDM2B_26808549_Chip-Seq_K562_Human1.69240301
49* RARA_24833708_ChIP-Seq_LIVER_Mouse1.68967004
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.68887755
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68308189
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66784083
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63605841
54CTCF_21964334_Chip-Seq_Bcells_Human1.62387648
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61140995
56CTCF_21964334_ChIP-Seq_BJAB-B_Human1.60037433
57* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59021020
58CTCF_20526341_ChIP-Seq_ESCs_Human1.58585991
59CTCF_27219007_Chip-Seq_Bcells_Human1.57189214
60FOXP1_21924763_ChIP-Seq_HESCs_Human1.57143028
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.56566970
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.53925741
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53535319
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51625025
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50904959
66* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50660086
67RACK7_27058665_Chip-Seq_MCF-7_Human1.47879024
68* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47707989
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45999662
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.45843509
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.44726698
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43733545
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43347054
74OCT4_20526341_ChIP-Seq_ESCs_Human1.41899786
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41719315
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41369749
77* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41333904
78NANOG_20526341_ChIP-Seq_ESCs_Human1.40210430
79* CTCF_26484167_Chip-Seq_Bcells_Mouse1.39635412
80* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38630306
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.38627113
82PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37104991
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35509473
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35477659
85* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.34015187
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33987939
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33616874
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33262514
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30960838
90* YY1_22570637_ChIP-Seq_MALME-3M_Human1.30004912
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29856302
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29398975
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29114634
94TP53_22127205_ChIP-Seq_IMR90_Human1.28718610
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28205580
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27505548
97SOX3_22085726_ChIP-Seq_NPCs_Mouse1.27148723
98SA1_27219007_Chip-Seq_Bcells_Human1.26940139
99* CREB1_26743006_Chip-Seq_LNCaP_Human1.26233349
100* XRN2_22483619_ChIP-Seq_HELA_Human1.25567000
101ERA_21632823_ChIP-Seq_H3396_Human1.24667497
102MYC_19829295_ChIP-Seq_ESCs_Human1.23824991
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.23815531
104CIITA_25753668_ChIP-Seq_RAJI_Human1.22376624
105DROSHA_22980978_ChIP-Seq_HELA_Human1.22004148
106SPI1_20517297_ChIP-Seq_HL60_Human1.21786571
107P68_20966046_ChIP-Seq_HELA_Human1.21272541
108* REST_18959480_ChIP-ChIP_MESCs_Mouse1.20854406
109TAF2_19829295_ChIP-Seq_ESCs_Human1.20673189
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.18972491
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.18966342
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16731737
113OCT4_19829295_ChIP-Seq_ESCs_Human1.16145976
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15653779
115KDM2B_26808549_Chip-Seq_DND41_Human1.15647334
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14934859
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.13904019
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13483689
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.13220143
120SMC4_20622854_ChIP-Seq_HELA_Human1.12931330
121NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.12853165
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12530041
123* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11412543
124P300_27268052_Chip-Seq_Bcells_Human1.11254692
125JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09605925
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09110721
127RAC3_21632823_ChIP-Seq_H3396_Human1.08280477
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08162078
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07823685
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07818271
131PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07510169
132* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07109178
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05341460
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.05149999
135RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04412125
136THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04107612
137SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03968281
138E2F7_22180533_ChIP-Seq_HELA_Human1.03809660
139* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03689695
140MAF_26560356_Chip-Seq_TH1_Human1.03607291
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02420702
142SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01745195
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99597915
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.99529974
145BCL6_27268052_Chip-Seq_Bcells_Human0.99244928
146GBX2_23144817_ChIP-Seq_PC3_Human0.98739211
147TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98464546
148VDR_21846776_ChIP-Seq_THP-1_Human0.97615673
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94883472
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94531009
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93676286
152IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92305604
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90223675
154MYC_22102868_ChIP-Seq_BL_Human0.88161812
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87928683
156ZNF263_19887448_ChIP-Seq_K562_Human0.87593970
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.87503090
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87480253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.30807451
2MP0004859_abnormal_synaptic_plasticity3.90189805
3MP0005171_absent_coat_pigmentation3.57423900
4MP0002638_abnormal_pupillary_reflex3.45410086
5MP0001986_abnormal_taste_sensitivity2.97473636
6MP0000747_muscle_weakness2.88454598
7MP0000749_muscle_degeneration2.86949923
8MP0003635_abnormal_synaptic_transmissio2.68624591
9MP0003136_yellow_coat_color2.63520672
10MP0002106_abnormal_muscle_physiology2.44679875
11MP0004270_analgesia2.35116713
12MP0005623_abnormal_meninges_morphology2.34222648
13MP0005330_cardiomyopathy2.33510583
14MP0004036_abnormal_muscle_relaxation2.32413339
15MP0003283_abnormal_digestive_organ2.29437363
16MP0003938_abnormal_ear_development2.27244128
17MP0002063_abnormal_learning/memory/cond2.21933923
18MP0000778_abnormal_nervous_system2.21060633
19MP0004087_abnormal_muscle_fiber2.19321744
20MP0004858_abnormal_nervous_system2.17752663
21MP0009046_muscle_twitch2.16083236
22MP0005174_abnormal_tail_pigmentation2.07606242
23MP0006292_abnormal_olfactory_placode10.4595659
24MP0002160_abnormal_reproductive_system1.99898107
25MP0005369_muscle_phenotype1.98834357
26MP0003566_abnormal_cell_adhesion1.96589171
27MP0001188_hyperpigmentation1.92939768
28MP0003879_abnormal_hair_cell1.92117671
29MP0003880_abnormal_central_pattern1.88099958
30MP0003122_maternal_imprinting1.80537590
31MP0002064_seizures1.78552558
32MP0008877_abnormal_DNA_methylation1.77316932
33MP0004133_heterotaxia1.77197645
34MP0003119_abnormal_digestive_system1.69583775
35MP0009745_abnormal_behavioral_response1.69172573
36MP0002184_abnormal_innervation1.68801449
37MP0002837_dystrophic_cardiac_calcinosis1.67685435
38MP0001486_abnormal_startle_reflex1.62580492
39MP0005167_abnormal_blood-brain_barrier1.61630060
40MP0003693_abnormal_embryo_hatching1.59712503
41MP0003861_abnormal_nervous_system1.57819539
42MP0005620_abnormal_muscle_contractility1.57294307
43MP0000566_synostosis1.56639794
44MP0002282_abnormal_trachea_morphology1.55437991
45MP0002822_catalepsy1.53563767
46MP0000003_abnormal_adipose_tissue1.53190884
47MP0004142_abnormal_muscle_tone1.49630977
48MP0002572_abnormal_emotion/affect_behav1.48900007
49MP0000428_abnormal_craniofacial_morphol1.46918331
50MP0004811_abnormal_neuron_physiology1.46728765
51MP0003091_abnormal_cell_migration1.44204504
52MP0002269_muscular_atrophy1.44135632
53MP0002733_abnormal_thermal_nociception1.42025830
54MP0000955_abnormal_spinal_cord1.41668128
55MP0002210_abnormal_sex_determination1.40790711
56MP0005409_darkened_coat_color1.40065145
57MP0001348_abnormal_lacrimal_gland1.40023270
58MP0002882_abnormal_neuron_morphology1.39842816
59MP0002152_abnormal_brain_morphology1.38374927
60MP0005410_abnormal_fertilization1.37753682
61MP0008789_abnormal_olfactory_epithelium1.36811975
62MP0004742_abnormal_vestibular_system1.36294496
63MP0000013_abnormal_adipose_tissue1.35584099
64MP0000750_abnormal_muscle_regeneration1.33772027
65MP0001661_extended_life_span1.33381137
66MP0001984_abnormal_olfaction1.31026300
67MP0000751_myopathy1.30135734
68MP0002102_abnormal_ear_morphology1.29506422
69MP0006276_abnormal_autonomic_nervous1.26907471
70MP0002272_abnormal_nervous_system1.26268708
71MP0000733_abnormal_muscle_development1.25874175
72MP0002734_abnormal_mechanical_nocicepti1.24675701
73MP0005666_abnormal_adipose_tissue1.23989384
74MP0001919_abnormal_reproductive_system1.22180382
75MP0005423_abnormal_somatic_nervous1.22068436
76MP0003303_peritoneal_inflammation1.21391229
77MP0005389_reproductive_system_phenotype1.21369859
78MP0005375_adipose_tissue_phenotype1.19308904
79MP0004215_abnormal_myocardial_fiber1.19130709
80MP0005551_abnormal_eye_electrophysiolog1.19116949
81MP0003690_abnormal_glial_cell1.18244924
82MP0005083_abnormal_biliary_tract1.18095743
83MP0001286_abnormal_eye_development1.17117970
84MP0004233_abnormal_muscle_weight1.15961960
85MP0003935_abnormal_craniofacial_develop1.15623110
86MP0002557_abnormal_social/conspecific_i1.14322420
87MP0002332_abnormal_exercise_endurance1.13808490
88MP0001968_abnormal_touch/_nociception1.11628966
89MP0002081_perinatal_lethality1.11343393
90MP0006072_abnormal_retinal_apoptosis1.09558416
91MP0001929_abnormal_gametogenesis1.08067389
92MP0003755_abnormal_palate_morphology1.07441918
93MP0004885_abnormal_endolymph1.06911711
94MP0002127_abnormal_cardiovascular_syste1.06564036
95MP0001756_abnormal_urination1.05371254
96MP0008875_abnormal_xenobiotic_pharmacok1.04854339
97MP0001440_abnormal_grooming_behavior1.04329381
98MP0008932_abnormal_embryonic_tissue1.03927908
99MP0003123_paternal_imprinting1.02260442
100MP0002067_abnormal_sensory_capabilities1.01987714
101MP0005377_hearing/vestibular/ear_phenot1.00381065
102MP0003878_abnormal_ear_physiology1.00381065
103MP0004185_abnormal_adipocyte_glucose1.00012952
104MP0005253_abnormal_eye_physiology0.99793358
105MP0004130_abnormal_muscle_cell0.99012091
106MP0005394_taste/olfaction_phenotype0.98626122
107MP0005499_abnormal_olfactory_system0.98626122
108MP0002066_abnormal_motor_capabilities/c0.98504910
109MP0004084_abnormal_cardiac_muscle0.97332943
110MP0006036_abnormal_mitochondrial_physio0.97234635
111MP0003385_abnormal_body_wall0.96780484
112MP0003718_maternal_effect0.96585995
113MP0001765_abnormal_ion_homeostasis0.95510694
114MP0001970_abnormal_pain_threshold0.95242892
115MP0003698_abnormal_male_reproductive0.94708404
116MP0004272_abnormal_basement_membrane0.93940828
117MP0004043_abnormal_pH_regulation0.93632595
118MP0002752_abnormal_somatic_nervous0.93457735
119MP0003646_muscle_fatigue0.90325660
120MP0005670_abnormal_white_adipose0.89763102
121MP0001346_abnormal_lacrimal_gland0.88992141
122MP0003137_abnormal_impulse_conducting0.88121373
123MP0002736_abnormal_nociception_after0.88048200
124MP0003705_abnormal_hypodermis_morpholog0.86699979
125MP0003787_abnormal_imprinting0.85673749
126MP0000049_abnormal_middle_ear0.83785380
127MP0001145_abnormal_male_reproductive0.83640712
128MP0002751_abnormal_autonomic_nervous0.83480004
129MP0008770_decreased_survivor_rate0.83184808
130MP0000653_abnormal_sex_gland0.82776681
131MP0000569_abnormal_digit_pigmentation0.81187037
132MP0002876_abnormal_thyroid_physiology0.80619339
133MP0003121_genomic_imprinting0.79991233
134MP0000678_abnormal_parathyroid_gland0.79587909
135MP0005451_abnormal_body_composition0.79181649
136MP0009672_abnormal_birth_weight0.78763636
137MP0003942_abnormal_urinary_system0.77723345
138MP0003890_abnormal_embryonic-extraembry0.77541516
139MP0002108_abnormal_muscle_morphology0.77251183
140MP0003315_abnormal_perineum_morphology0.77232121
141MP0002972_abnormal_cardiac_muscle0.76699396
142MP0001324_abnormal_eye_pigmentation0.76211730
143MP0002932_abnormal_joint_morphology0.75742764
144MP0005248_abnormal_Harderian_gland0.73857528
145MP0005391_vision/eye_phenotype0.71570573
146MP0002116_abnormal_craniofacial_bone0.71049632
147MP0001664_abnormal_digestion0.70955099
148MP0002249_abnormal_larynx_morphology0.70813384
149MP0002909_abnormal_adrenal_gland0.69796185
150MP0002085_abnormal_embryonic_tissue0.67150130
151MP0000631_abnormal_neuroendocrine_gland0.66406798
152MP0010630_abnormal_cardiac_muscle0.65644508
153MP0000358_abnormal_cell_content/0.64546610
154MP0010769_abnormal_survival0.64285615
155MP0002082_postnatal_lethality0.64037923
156MP0010770_preweaning_lethality0.64037923
157MP0008004_abnormal_stomach_pH0.62981333
158MP0001293_anophthalmia0.62346488
159MP0002161_abnormal_fertility/fecundity0.61903900
160MP0004197_abnormal_fetal_growth/weight/0.61854251
161MP0010768_mortality/aging0.61707212
162MP0010030_abnormal_orbit_morphology0.60872584
163MP0003111_abnormal_nucleus_morphology0.60536339
164MP0000470_abnormal_stomach_morphology0.60158707
165MP0002971_abnormal_brown_adipose0.60139491
166MP0000759_abnormal_skeletal_muscle0.59278355
167MP0002114_abnormal_axial_skeleton0.59179956
168MP0002163_abnormal_gland_morphology0.59030704
169MP0001502_abnormal_circadian_rhythm0.58535165
170MP0004484_altered_response_of0.57245105
171MP0005332_abnormal_amino_acid0.56381435
172MP0005266_abnormal_metabolism0.53239264
173MP0000538_abnormal_urinary_bladder0.51966041
174MP0005584_abnormal_enzyme/coenzyme_acti0.51155520
175MP0000372_irregular_coat_pigmentation0.50811031
176MP0003699_abnormal_female_reproductive0.50506439
177MP0004381_abnormal_hair_follicle0.50092008

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.51541642
2Nemaline bodies (HP:0003798)6.18654810
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.04831690
4Exercise-induced myalgia (HP:0003738)6.03995899
5Submucous cleft hard palate (HP:0000176)5.14293103
6Myopathic facies (HP:0002058)5.06041781
7Hyperacusis (HP:0010780)4.74060196
8Neonatal respiratory distress (HP:0002643)4.73135974
9Abnormal number of incisors (HP:0011064)4.68742466
10Impaired vibration sensation in the lower limbs (HP:0002166)4.63219645
11Abnormality of the nasal septum (HP:0000419)4.60848886
12Type 1 muscle fiber predominance (HP:0003803)4.60714450
13Muscle hypertrophy of the lower extremities (HP:0008968)4.47956519
14Myotonia (HP:0002486)4.44957531
15Fetal akinesia sequence (HP:0001989)4.43100991
16Spastic gait (HP:0002064)4.42922989
17Exercise-induced muscle cramps (HP:0003710)4.35525076
18Testicular atrophy (HP:0000029)4.32392757
19Neoplasm of the heart (HP:0100544)4.31896409
20Urinary bladder sphincter dysfunction (HP:0002839)4.27753579
21Rib fusion (HP:0000902)4.16425604
22Abnormal umbilical cord blood vessels (HP:0011403)4.05168236
23Single umbilical artery (HP:0001195)4.05168236
24Abnormality of the fetal cardiovascular system (HP:0010948)4.05168236
25High anterior hairline (HP:0009890)4.04321887
26Rimmed vacuoles (HP:0003805)3.96161363
27Lymphangioma (HP:0100764)3.96016166
28Cortical dysplasia (HP:0002539)3.84831386
29Ependymoma (HP:0002888)3.81829475
30Calf muscle hypertrophy (HP:0008981)3.77513674
31Urinary urgency (HP:0000012)3.73997003
32Broad alveolar ridges (HP:0000187)3.71770980
33Aplasia of the musculature (HP:0100854)3.69981256
34Increased IgM level (HP:0003496)3.69881762
35Ulnar deviation of the wrist (HP:0003049)3.63465100
36Atelectasis (HP:0100750)3.60970065
37Abnormality of the labia minora (HP:0012880)3.57833735
38Ankle clonus (HP:0011448)3.51252498
39EMG: myopathic abnormalities (HP:0003458)3.49407142
40Popliteal pterygium (HP:0009756)3.48940153
41Dyschromatopsia (HP:0007641)3.33625669
42Mesangial abnormality (HP:0001966)3.33201790
43Rhabdomyolysis (HP:0003201)3.31861360
44Malignant hyperthermia (HP:0002047)3.30262931
45Distal arthrogryposis (HP:0005684)3.29856657
46Myoglobinuria (HP:0002913)3.21456516
47Muscle stiffness (HP:0003552)3.21332916
48Increased hepatocellular lipid droplets (HP:0006565)3.19004189
49Heart block (HP:0012722)3.16241202
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.13896396
51Abnormality of placental membranes (HP:0011409)3.06162906
52Amniotic constriction ring (HP:0009775)3.06162906
53Atrioventricular block (HP:0001678)3.05377204
54Centrally nucleated skeletal muscle fibers (HP:0003687)3.02586051
55Lipid accumulation in hepatocytes (HP:0006561)3.02183845
56Akinesia (HP:0002304)3.01916898
57Increased intramyocellular lipid droplets (HP:0012240)3.01834607
58Rectal fistula (HP:0100590)2.98921245
59Rectovaginal fistula (HP:0000143)2.98921245
60Narrow nasal bridge (HP:0000446)2.98604281
61Ulnar bowing (HP:0003031)2.97029683
62Drooling (HP:0002307)2.92594570
63Excessive salivation (HP:0003781)2.92594570
64Skin nodule (HP:0200036)2.88847417
65Calcaneovalgus deformity (HP:0001848)2.88818130
66Abnormal atrioventricular conduction (HP:0005150)2.88603713
67Insomnia (HP:0100785)2.87738060
68Renal Fanconi syndrome (HP:0001994)2.86953830
69Adrenal hypoplasia (HP:0000835)2.86294481
70Facial hemangioma (HP:0000329)2.84261202
71Myokymia (HP:0002411)2.82697488
72Astrocytoma (HP:0009592)2.82477153
73Abnormality of the astrocytes (HP:0100707)2.82477153
74Facial diplegia (HP:0001349)2.82464389
75Round ear (HP:0100830)2.82211126
76Male infertility (HP:0003251)2.79637285
77Increased muscle lipid content (HP:0009058)2.78320972
78Renovascular hypertension (HP:0100817)2.77217807
79Attenuation of retinal blood vessels (HP:0007843)2.75162015
80Hyperinsulinemic hypoglycemia (HP:0000825)2.74174242
81Asymmetric septal hypertrophy (HP:0001670)2.73754783
82Intestinal fistula (HP:0100819)2.73260972
83Hyperphosphatemia (HP:0002905)2.70870372
84Hyperthyroidism (HP:0000836)2.70242290
85Difficulty running (HP:0009046)2.67584329
86Supranuclear gaze palsy (HP:0000605)2.65672277
87Termporal pattern (HP:0011008)2.64378647
88Insidious onset (HP:0003587)2.64378647
89Abnormality of the intrinsic pathway (HP:0010989)2.62951400
90Overriding aorta (HP:0002623)2.62332211
91Abnormality of the calf musculature (HP:0001430)2.59855232
92Muscle fiber splitting (HP:0003555)2.57672785
93Poikiloderma (HP:0001029)2.56128120
94Vaginal fistula (HP:0004320)2.53667033
95Absent phalangeal crease (HP:0006109)2.52881459
96Renal duplication (HP:0000075)2.52631694
97Apathy (HP:0000741)2.49684235
98Abnormal drinking behavior (HP:0030082)2.48405795
99Polydipsia (HP:0001959)2.48405795
100Deformed tarsal bones (HP:0008119)2.46093101
101Elfin facies (HP:0004428)2.43156871
102Abnormality of the diencephalon (HP:0010662)2.40043371
103Hamartoma of the eye (HP:0010568)2.39681760
104Long toe (HP:0010511)2.35766225
105Squamous cell carcinoma (HP:0002860)2.33188097
106Hyporeflexia of lower limbs (HP:0002600)2.30791169
107Proximal placement of thumb (HP:0009623)2.28734281
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28231239
109Patellar aplasia (HP:0006443)2.28128393
110Abnormality of the left ventricular outflow tract (HP:0011103)2.27842636
111Subaortic stenosis (HP:0001682)2.27842636
112Prolonged partial thromboplastin time (HP:0003645)2.27815132
113Bony spicule pigmentary retinopathy (HP:0007737)2.27250399
114Annular pancreas (HP:0001734)2.27149499
115Abnormality of the corticospinal tract (HP:0002492)2.26712947
116Fatigable weakness (HP:0003473)2.26549793
117Abnormality of the neuromuscular junction (HP:0003398)2.26549793
118Abnormality of skeletal muscle fiber size (HP:0012084)2.24353221
119Abnormality of the umbilical cord (HP:0010881)2.23035609
120Stridor (HP:0010307)2.22000666
121Abnormality of the tricuspid valve (HP:0001702)2.20348364
122Short chin (HP:0000331)2.20229459
123Failure to thrive in infancy (HP:0001531)2.20130618
124Congenital stationary night blindness (HP:0007642)2.19947181
125Postural tremor (HP:0002174)2.17618346
126Joint hemorrhage (HP:0005261)2.17404547
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17012336
128Weak cry (HP:0001612)2.16842794
129Impaired vibratory sensation (HP:0002495)2.16134405
130Bundle branch block (HP:0011710)2.15823744
131Limb dystonia (HP:0002451)2.15320476
132Diminished motivation (HP:0000745)2.13843616
133Mutism (HP:0002300)2.10600046
134Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10330031
135Short 4th metacarpal (HP:0010044)2.10330031
136Aplasia/Hypoplasia of the patella (HP:0006498)2.09078599
137Progressive muscle weakness (HP:0003323)2.08704637
138Thin bony cortex (HP:0002753)2.07821066
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06740315
140Degeneration of the lateral corticospinal tracts (HP:0002314)2.06740315
141Turricephaly (HP:0000262)2.06573365
142Respiratory difficulties (HP:0002880)2.06093459
143Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04556861
144Genetic anticipation (HP:0003743)2.04030123
145Visceral angiomatosis (HP:0100761)2.03706618
146Dysphonia (HP:0001618)2.02379317
147Thin ribs (HP:0000883)2.00936618
148Flat cornea (HP:0007720)2.00185269
149Shallow orbits (HP:0000586)2.00164978
150Abnormality of the incisor (HP:0000676)2.00106190
151Deviation of the thumb (HP:0009603)1.99186148
152Glioma (HP:0009733)1.98999157
153Focal segmental glomerulosclerosis (HP:0000097)1.98160433
154Patellar dislocation (HP:0002999)1.98143300
155Abnormal finger flexion creases (HP:0006143)1.97632625
156Focal motor seizures (HP:0011153)1.97616775
157Shoulder girdle muscle weakness (HP:0003547)1.97543188
158Hypoalbuminemia (HP:0003073)1.97245190
159Abnormal albumin level (HP:0012116)1.97245190
160Abnormality of the alveolar ridges (HP:0006477)1.96812167
161Choroideremia (HP:0001139)1.95711253
162Hemorrhage of the eye (HP:0011885)1.95314046
163Exertional dyspnea (HP:0002875)1.94288549
164Precocious puberty (HP:0000826)1.93938071
165Hemiparesis (HP:0001269)1.92900923
166Pseudobulbar signs (HP:0002200)1.91914294
167Angiofibromas (HP:0010615)1.91855012
168Adenoma sebaceum (HP:0009720)1.91855012
169Long clavicles (HP:0000890)1.91137888
170Lower limb muscle weakness (HP:0007340)1.90952697
171Increased variability in muscle fiber diameter (HP:0003557)1.90194506
172Porencephaly (HP:0002132)1.89693771
173Neonatal onset (HP:0003623)1.89472134
174Protruding ear (HP:0000411)1.89222831
175Sporadic (HP:0003745)1.88489520
176Generalized muscle weakness (HP:0003324)1.88383132
177Neoplasm of striated muscle (HP:0009728)1.84685330
178Mildly elevated creatine phosphokinase (HP:0008180)1.84477544
179Hyperkalemia (HP:0002153)1.84389210
180Camptodactyly of toe (HP:0001836)1.81415613
181Neck muscle weakness (HP:0000467)1.81274214
182Hemangiomatosis (HP:0007461)1.80209300
183Disinhibition (HP:0000734)1.79376249
184Attention deficit hyperactivity disorder (HP:0007018)1.79319255
185Clonus (HP:0002169)1.79248385
186Abnormality of salivation (HP:0100755)1.77605924
187Neuronal loss in central nervous system (HP:0002529)1.76553442
188Broad-based gait (HP:0002136)1.75270639
189Bronchomalacia (HP:0002780)1.75154781
190Back pain (HP:0003418)1.74830967
191Upper limb amyotrophy (HP:0009129)1.74806909
192Distal upper limb amyotrophy (HP:0007149)1.74806909
193Median cleft lip (HP:0000161)1.74751455
194Genu recurvatum (HP:0002816)1.74679536
195Large earlobe (HP:0009748)1.73551972
196Abnormality of the 4th metacarpal (HP:0010012)1.72324260
197Spastic paraplegia (HP:0001258)1.72309498
198Tented upper lip vermilion (HP:0010804)1.70737933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.38103588
2MAPK155.14057592
3EEF2K4.12449838
4TTN3.52756122
5WNK42.82543845
6DYRK1B2.61665329
7MUSK2.56514496
8PRKD22.49912811
9LIMK12.28435179
10DYRK32.27391273
11INSRR14.7075161
12CCNB11.92604350
13MARK21.88866031
14PKN11.87149727
15MAP2K31.85107812
16MAPKAPK31.79226510
17MARK11.75340945
18MAP3K71.73729453
19BRSK11.63575075
20MAPK121.59784522
21SIK21.32630862
22CAMK41.25680901
23MAP2K61.19478928
24MAP3K21.07011148
25PINK11.06922262
26AKT21.01670872
27PKN20.99456224
28ARAF0.99233508
29TRPM70.95582426
30DYRK20.89963190
31NTRK20.88860808
32EPHA30.88690380
33CAMK10.88007663
34KSR20.85169785
35MAPK130.84392972
36IRAK10.82067266
37IRAK20.81668374
38TLK10.81643998
39MAP3K130.80557458
40ERBB20.78281755
41STK160.77831762
42AURKA0.77297867
43ICK0.77155739
44BRAF0.77089249
45MAP3K90.76884824
46PIK3CG0.75671806
47PLK10.74489316
48PRKAA20.72654181
49SGK4940.71890807
50SGK2230.71890807
51CDC42BPA0.71875214
52MAP2K20.68610767
53STK390.68499704
54MAPKAPK50.66296939
55UHMK10.66250485
56PDK20.65824652
57RPS6KA20.65349685
58WNK10.63865241
59IRAK30.62665887
60PDPK10.60967019
61PRKAA10.57683428
62PIK3CA0.54089542
63MAP3K40.52549577
64ALK0.52318564
65KSR10.52269040
66CAMKK20.51987470
67EPHA20.50963679
68RPS6KB20.50751171
69MAPK110.50235255
70IRAK40.50064141
71PHKG10.49889582
72PHKG20.49889582
73MKNK20.49698040
74PRKD10.49205350
75NME10.49054528
76MAPKAPK20.46285807
77PRKACA0.45699153
78OXSR10.45011497
79MAP3K110.44652560
80PRKCI0.44279373
81MAPK100.43194825
82RPS6KC10.43083332
83RPS6KL10.43083332
84MARK30.42096566
85PRKCZ0.41568671
86EPHA40.41092423
87SCYL20.40378873
88CAMK2G0.40268830
89MAP2K70.39735629
90CDK10.36937271
91MOS0.36753426
92NTRK30.36229379
93TYRO30.36025361
94LRRK20.35515290
95CASK0.34891921
96STK110.34850621
97NEK10.34787132
98SGK30.34642275
99CDK50.34506428
100ABL20.33894149
101MTOR0.33866607
102MAPK80.33530180
103RPS6KA60.32567824
104DAPK20.32053977
105DAPK10.31917421
106CDK20.31851393
107MAPK70.31267006
108GSK3B0.29591528
109CDK40.29432403
110CAMK2D0.28127688
111SGK10.27518145
112GRK60.27134725
113RPS6KB10.27051017
114PRKG10.26765801
115MAPK90.26648107
116PRKACB0.26646955
117MINK10.25905969
118PAK10.25725707
119CDK140.25110726
120FES0.24377763
121EPHB20.24000784
122TRIB30.23639677
123RPS6KA50.23493261
124DYRK1A0.22421718
125DAPK30.22231463
126TSSK60.22139212
127RET0.21479366
128CDK150.21035196
129CHEK20.21009047
130CDK180.20654666
131CDK190.20537254
132BLK0.20375184
133BUB10.20312025
134RPS6KA10.19722544
135BMX0.19096155
136TESK20.18741021
137MAP3K100.18464997
138ROCK20.18420934
139LATS20.18370281
140PRKCG0.17669690
141PRKD30.17329767
142PRKCH0.17294318
143BRD40.16753514
144CDK11A0.15702591
145CAMK1D0.15144703
146CSNK1D0.14650200
147TTK0.14105923
148CDK120.13929511
149CSNK1E0.13493207
150PNCK0.13267949
151CAMK1G0.12949174
152NTRK10.12897273
153RIPK40.12585859
154MAP2K40.12377145
155PAK60.12000947
156TBK10.11381103
157PTK60.11338109
158CAMKK10.10610110

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.85954793
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.71708121
3Circadian rhythm_Homo sapiens_hsa047102.59395792
4Axon guidance_Homo sapiens_hsa043602.55526026
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46728076
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.46141921
7Glutamatergic synapse_Homo sapiens_hsa047242.45027324
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25127411
9mTOR signaling pathway_Homo sapiens_hsa041502.16761947
10Gap junction_Homo sapiens_hsa045402.05041106
11Alcoholism_Homo sapiens_hsa050342.01175499
12Fructose and mannose metabolism_Homo sapiens_hsa000511.96611346
13Oxytocin signaling pathway_Homo sapiens_hsa049211.84966992
14GABAergic synapse_Homo sapiens_hsa047271.84196436
15Morphine addiction_Homo sapiens_hsa050321.79991670
16Nicotine addiction_Homo sapiens_hsa050331.78964028
17Pyruvate metabolism_Homo sapiens_hsa006201.78010201
18Long-term potentiation_Homo sapiens_hsa047201.70983771
19Synaptic vesicle cycle_Homo sapiens_hsa047211.68773201
20Parkinsons disease_Homo sapiens_hsa050121.67978886
21Ovarian steroidogenesis_Homo sapiens_hsa049131.66237406
22Prostate cancer_Homo sapiens_hsa052151.65884839
23Olfactory transduction_Homo sapiens_hsa047401.60946300
24Calcium signaling pathway_Homo sapiens_hsa040201.60024646
25Ribosome_Homo sapiens_hsa030101.59202311
26Circadian entrainment_Homo sapiens_hsa047131.56930309
27Glucagon signaling pathway_Homo sapiens_hsa049221.52587822
28GnRH signaling pathway_Homo sapiens_hsa049121.51894553
29Cardiac muscle contraction_Homo sapiens_hsa042601.51370967
30One carbon pool by folate_Homo sapiens_hsa006701.45118717
31Cocaine addiction_Homo sapiens_hsa050301.44398113
32Hedgehog signaling pathway_Homo sapiens_hsa043401.42879335
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38889268
34Oxidative phosphorylation_Homo sapiens_hsa001901.38520850
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34071459
36Amphetamine addiction_Homo sapiens_hsa050311.30543050
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30178499
38Prion diseases_Homo sapiens_hsa050201.30060812
39Lysine degradation_Homo sapiens_hsa003101.28511534
40Regulation of autophagy_Homo sapiens_hsa041401.27708284
41Type II diabetes mellitus_Homo sapiens_hsa049301.26456566
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26353854
43Dopaminergic synapse_Homo sapiens_hsa047281.25246012
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.24438610
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23593923
46Glioma_Homo sapiens_hsa052141.23592319
47Long-term depression_Homo sapiens_hsa047301.23310616
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21849304
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21568635
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21495257
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20144762
52Dilated cardiomyopathy_Homo sapiens_hsa054141.18313543
53Cholinergic synapse_Homo sapiens_hsa047251.17873000
54MicroRNAs in cancer_Homo sapiens_hsa052061.16461475
55Insulin signaling pathway_Homo sapiens_hsa049101.15274538
56Huntingtons disease_Homo sapiens_hsa050161.15210628
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14757598
58Sulfur metabolism_Homo sapiens_hsa009201.09874092
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.08896335
60Basal transcription factors_Homo sapiens_hsa030221.08857615
61Oocyte meiosis_Homo sapiens_hsa041141.08736099
62Fanconi anemia pathway_Homo sapiens_hsa034601.07193863
63Alzheimers disease_Homo sapiens_hsa050101.05323361
64Melanogenesis_Homo sapiens_hsa049161.04532721
65Arginine biosynthesis_Homo sapiens_hsa002201.04154309
66Taste transduction_Homo sapiens_hsa047421.03849129
67Systemic lupus erythematosus_Homo sapiens_hsa053221.03791682
68Choline metabolism in cancer_Homo sapiens_hsa052311.03735985
69Inositol phosphate metabolism_Homo sapiens_hsa005621.03346567
70ErbB signaling pathway_Homo sapiens_hsa040121.02329810
71Serotonergic synapse_Homo sapiens_hsa047261.01508983
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99744313
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99253469
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96395186
75MAPK signaling pathway_Homo sapiens_hsa040100.93805663
76Sphingolipid metabolism_Homo sapiens_hsa006000.92461392
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91410670
78Dorso-ventral axis formation_Homo sapiens_hsa043200.91209082
79Phototransduction_Homo sapiens_hsa047440.91162206
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90517459
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.89972554
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.89098009
83Pentose phosphate pathway_Homo sapiens_hsa000300.88190938
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86543773
85Estrogen signaling pathway_Homo sapiens_hsa049150.86444968
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85575418
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82681271
88Endocytosis_Homo sapiens_hsa041440.81895141
89AMPK signaling pathway_Homo sapiens_hsa041520.81650668
90Carbon metabolism_Homo sapiens_hsa012000.81372483
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80775369
92Non-small cell lung cancer_Homo sapiens_hsa052230.79756336
93Phenylalanine metabolism_Homo sapiens_hsa003600.79666761
94Renin secretion_Homo sapiens_hsa049240.77346150
95Proteoglycans in cancer_Homo sapiens_hsa052050.76039063
96Cell cycle_Homo sapiens_hsa041100.75680202
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74525257
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74046962
99Biosynthesis of amino acids_Homo sapiens_hsa012300.73563385
100Insulin resistance_Homo sapiens_hsa049310.73510975
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72540702
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.72419040
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71904470
104VEGF signaling pathway_Homo sapiens_hsa043700.71859308
105Gastric acid secretion_Homo sapiens_hsa049710.71750933
106Insulin secretion_Homo sapiens_hsa049110.71482177
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71400888
108Renal cell carcinoma_Homo sapiens_hsa052110.71227643
109Bladder cancer_Homo sapiens_hsa052190.71202772
110Arginine and proline metabolism_Homo sapiens_hsa003300.70951439
111Salivary secretion_Homo sapiens_hsa049700.70842946
112Chronic myeloid leukemia_Homo sapiens_hsa052200.70224504
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70174073
114Other glycan degradation_Homo sapiens_hsa005110.69919960
115Sulfur relay system_Homo sapiens_hsa041220.69116845
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69063848
117mRNA surveillance pathway_Homo sapiens_hsa030150.68345251
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67650925
119RNA degradation_Homo sapiens_hsa030180.66283004
120Melanoma_Homo sapiens_hsa052180.64804752
121Type I diabetes mellitus_Homo sapiens_hsa049400.64602125
122Rap1 signaling pathway_Homo sapiens_hsa040150.63144297
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62135180
124Ras signaling pathway_Homo sapiens_hsa040140.61274203
125cAMP signaling pathway_Homo sapiens_hsa040240.61143675
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60213790
127Acute myeloid leukemia_Homo sapiens_hsa052210.60065684
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59689811
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.59330251
130RNA polymerase_Homo sapiens_hsa030200.58961917
131Collecting duct acid secretion_Homo sapiens_hsa049660.58870911
132FoxO signaling pathway_Homo sapiens_hsa040680.58480321
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57809309
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.57660188
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56888621
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55154858
137Endometrial cancer_Homo sapiens_hsa052130.54303475
138Viral carcinogenesis_Homo sapiens_hsa052030.53886350
139Phagosome_Homo sapiens_hsa041450.53715109
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52918888
141HIF-1 signaling pathway_Homo sapiens_hsa040660.52854634
142Basal cell carcinoma_Homo sapiens_hsa052170.52321177
143Propanoate metabolism_Homo sapiens_hsa006400.52287769
144p53 signaling pathway_Homo sapiens_hsa041150.51740231
145Thyroid cancer_Homo sapiens_hsa052160.49437501
146Nitrogen metabolism_Homo sapiens_hsa009100.48353886
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47541020
148Base excision repair_Homo sapiens_hsa034100.47373730
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.45341259
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43543635
151Metabolic pathways_Homo sapiens_hsa011000.42867299
152ABC transporters_Homo sapiens_hsa020100.42367675
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41584464
154Galactose metabolism_Homo sapiens_hsa000520.41500787
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38816712
156Purine metabolism_Homo sapiens_hsa002300.37895084
157Hippo signaling pathway_Homo sapiens_hsa043900.35512830

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