GCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.40213774
2negative regulation of cell killing (GO:0031342)6.09271315
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.09271315
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.02741604
5axon ensheathment in central nervous system (GO:0032291)5.96804897
6central nervous system myelination (GO:0022010)5.96804897
7positive regulation of gamma-delta T cell activation (GO:0046645)5.92700191
8neutrophil activation involved in immune response (GO:0002283)5.85791268
9macrophage activation involved in immune response (GO:0002281)5.70291314
10leukocyte migration involved in inflammatory response (GO:0002523)5.68668535
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.57669508
12detection of external biotic stimulus (GO:0098581)5.48388242
13response to peptidoglycan (GO:0032494)5.28786751
14regulation of B cell receptor signaling pathway (GO:0050855)5.10475274
15regulation of interferon-beta biosynthetic process (GO:0045357)5.08719442
16cellular extravasation (GO:0045123)4.99354928
17detection of biotic stimulus (GO:0009595)4.77437095
18response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.68353203
19response to host (GO:0075136)4.68353203
20response to host defenses (GO:0052200)4.68353203
21macrophage activation (GO:0042116)4.66151709
22positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.57733351
23leukocyte aggregation (GO:0070486)4.57335726
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.53824172
25negative regulation of interleukin-12 production (GO:0032695)4.50199291
26antigen processing and presentation of endogenous antigen (GO:0019883)4.49996807
27superoxide anion generation (GO:0042554)4.46979779
28phagosome maturation (GO:0090382)4.43464519
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.36968801
30sequestering of metal ion (GO:0051238)4.26801296
31respiratory burst (GO:0045730)4.25853564
32neutrophil activation (GO:0042119)4.25695026
33negative regulation of neurotransmitter secretion (GO:0046929)4.24655367
34neutrophil mediated immunity (GO:0002446)4.22944254
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.21792771
36regulation of gamma-delta T cell activation (GO:0046643)4.16513715
37hydrogen peroxide biosynthetic process (GO:0050665)4.15672183
38myeloid cell activation involved in immune response (GO:0002275)4.09107546
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06825853
40fatty acid elongation (GO:0030497)4.05187376
41reactive oxygen species biosynthetic process (GO:1903409)4.01742482
42granulocyte activation (GO:0036230)3.97655300
43response to interleukin-15 (GO:0070672)3.97451178
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96741730
45immunoglobulin mediated immune response (GO:0016064)3.87936003
46myelin maintenance (GO:0043217)3.77023699
47negative regulation of neurotransmitter transport (GO:0051589)3.73809717
48positive regulation of actin filament depolymerization (GO:0030836)3.73022115
49positive regulation of type 2 immune response (GO:0002830)3.71776488
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.71489741
51negative regulation of T cell mediated immunity (GO:0002710)3.70892708
52negative regulation of leukocyte mediated immunity (GO:0002704)3.68961327
53regulation of gamma-delta T cell differentiation (GO:0045586)3.68196526
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.68018919
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.67879994
56long-chain fatty acid biosynthetic process (GO:0042759)3.64519735
57myeloid leukocyte mediated immunity (GO:0002444)3.64448586
58cellular response to interleukin-15 (GO:0071350)3.61782927
59regulation of mast cell degranulation (GO:0043304)3.59177866
60positive regulation of mast cell activation (GO:0033005)3.57379039
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.45706293
62B cell receptor signaling pathway (GO:0050853)3.44788325
63intracellular pH reduction (GO:0051452)3.41983698
64positive regulation of interferon-alpha production (GO:0032727)3.41228101
65antigen processing and presentation via MHC class Ib (GO:0002475)3.37942883
66regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36596979
67chronic inflammatory response (GO:0002544)3.34758707
68positive regulation of toll-like receptor signaling pathway (GO:0034123)3.34290296
69T-helper 1 type immune response (GO:0042088)3.33837274
70regulation of mast cell activation (GO:0033003)3.33447911
71regulation of mast cell activation involved in immune response (GO:0033006)3.32994938
72protein neddylation (GO:0045116)3.23639238
73dendritic cell migration (GO:0036336)3.23492303
74negative regulation of T-helper cell differentiation (GO:0045623)3.23070120
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.23070120
76defense response to protozoan (GO:0042832)3.21532329
77regulation of activation of Janus kinase activity (GO:0010533)3.21153777
78B cell mediated immunity (GO:0019724)3.19733737
79positive regulation of cellular amide metabolic process (GO:0034250)3.19565202
80negative regulation of immunoglobulin mediated immune response (GO:0002890)3.19461750
81negative regulation of B cell mediated immunity (GO:0002713)3.19461750
82regulation of interferon-alpha production (GO:0032647)3.19145488
83negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.18413541
84pH reduction (GO:0045851)3.15964508
85cellular response to type I interferon (GO:0071357)3.15251808
86type I interferon signaling pathway (GO:0060337)3.15251808
87myeloid leukocyte activation (GO:0002274)3.13110763
88response to type I interferon (GO:0034340)3.11489561
89negative regulation of macroautophagy (GO:0016242)3.10689040
90positive regulation of mast cell degranulation (GO:0043306)3.10644489
91positive regulation of mast cell activation involved in immune response (GO:0033008)3.10644489
92regulation of B cell differentiation (GO:0045577)3.10394015
93neutrophil chemotaxis (GO:0030593)3.09882761
94production of molecular mediator involved in inflammatory response (GO:0002532)3.09392967
95regulation of interleukin-8 biosynthetic process (GO:0045414)3.09362901
96regulation of interleukin-6 biosynthetic process (GO:0045408)3.08433022
97leukocyte mediated cytotoxicity (GO:0001909)3.07496690
98regulation of leukocyte degranulation (GO:0043300)3.06728125
99myelination (GO:0042552)3.05686074
100activated T cell proliferation (GO:0050798)3.05664763
101ensheathment of neurons (GO:0007272)3.05658852
102axon ensheathment (GO:0008366)3.05658852
103regulation of T-helper 2 cell differentiation (GO:0045628)3.05205247
104negative regulation of protein localization to cell surface (GO:2000009)3.04228250
105positive regulation of T-helper cell differentiation (GO:0045624)3.03544052
106neutrophil migration (GO:1990266)3.02169621
107dendritic cell chemotaxis (GO:0002407)3.01909863
108positive regulation of B cell differentiation (GO:0045579)2.98515361
109presynaptic membrane assembly (GO:0097105)2.98382701
110presynaptic membrane organization (GO:0097090)2.96647765
111interferon-gamma-mediated signaling pathway (GO:0060333)2.96066064
112negative regulation of exocytosis (GO:0045920)2.95584417
113positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.94905890
114negative regulation of adaptive immune response (GO:0002820)2.94199951
115regulation of tolerance induction (GO:0002643)2.93432058
116positive regulation of interferon-beta production (GO:0032728)2.93401488
117positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.87726819
118mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.87726819
119deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.86950100
120response to fungus (GO:0009620)2.83601324
121L-amino acid import (GO:0043092)2.79841275
122regulation of amyloid precursor protein catabolic process (GO:1902991)2.78335484
123cholesterol biosynthetic process (GO:0006695)2.76894771
124regulation of beta-amyloid formation (GO:1902003)2.76661505
125disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.76299167
126killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.76299167
127positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75569897
128detection of other organism (GO:0098543)2.71256962
129regulation of collateral sprouting (GO:0048670)2.68990083
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68700641
131regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66657660
132interleukin-6-mediated signaling pathway (GO:0070102)2.65534532
133organ or tissue specific immune response (GO:0002251)2.64545224
134positive regulation of T cell migration (GO:2000406)2.64376221
135regulation of T-helper 1 cell differentiation (GO:0045625)2.61135150
136regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.60258740
137glycosylceramide metabolic process (GO:0006677)2.60019028
138detection of bacterium (GO:0016045)2.58361485
139water-soluble vitamin biosynthetic process (GO:0042364)2.58074682
140positive regulation of lymphocyte migration (GO:2000403)2.55433360
141regulation of T-helper cell differentiation (GO:0045622)2.54975317
142microglial cell activation (GO:0001774)2.54694476
143response to host immune response (GO:0052572)2.54339088
144response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54339088
145sterol biosynthetic process (GO:0016126)2.51324954
146nerve growth factor signaling pathway (GO:0038180)2.47715388
147cellular response to gamma radiation (GO:0071480)2.47351544
148regulation of podosome assembly (GO:0071801)2.46502372
149negative regulation of growth of symbiont in host (GO:0044130)2.46240742
150negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.46240742
151modulation of growth of symbiont involved in interaction with host (GO:0044144)2.46240742
152regulation of growth of symbiont in host (GO:0044126)2.46240742
153GPI anchor biosynthetic process (GO:0006506)2.46080711
154Rap protein signal transduction (GO:0032486)2.45695086
155regulation of RIG-I signaling pathway (GO:0039535)2.44454236
156regulation of T cell migration (GO:2000404)2.43759399
157regulation of chemokine biosynthetic process (GO:0045073)2.43384249
158positive regulation of heat generation (GO:0031652)2.42485698
159response to lipoprotein particle (GO:0055094)2.41147176
160positive regulation by symbiont of host defense response (GO:0052509)2.41143500
161modulation by symbiont of host defense response (GO:0052031)2.41143500
162modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41143500
163modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41143500
164positive regulation by organism of defense response of other organism involved in symbiotic interact2.41143500
165modulation by symbiont of host immune response (GO:0052553)2.41143500
166photoreceptor cell differentiation (GO:0046530)2.38853355
167eye photoreceptor cell differentiation (GO:0001754)2.38853355
168leukotriene metabolic process (GO:0006691)2.38828636
169leukocyte degranulation (GO:0043299)2.38749513
170positive regulation of monocyte chemotaxis (GO:0090026)2.38639586
171signal peptide processing (GO:0006465)2.38440134
172regulation of immunoglobulin secretion (GO:0051023)2.38400912
173transferrin transport (GO:0033572)2.37113182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.75622190
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38230632
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05945504
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.29869387
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05335490
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04286396
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.81776931
8RUNX_20019798_ChIP-Seq_JUKART_Human2.81638992
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.66202055
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61041766
11SPI1_23127762_ChIP-Seq_K562_Human2.59376257
12MYB_26560356_Chip-Seq_TH2_Human2.48539124
13SCL_19346495_ChIP-Seq_HPC-7_Human2.48275165
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47550849
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45920857
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45535552
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.44169705
18VDR_22108803_ChIP-Seq_LS180_Human2.43660907
19TAF15_26573619_Chip-Seq_HEK293_Human2.40979928
20GBX2_23144817_ChIP-Seq_PC3_Human2.39249555
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32630996
22* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29213996
23VDR_24763502_ChIP-Seq_THP-1_Human2.28228237
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27750451
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25650673
26* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.16557245
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11009120
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08980872
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07835723
30MYB_26560356_Chip-Seq_TH1_Human2.01351364
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01179059
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.98820879
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.96829679
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96243006
35MAF_26560356_Chip-Seq_TH1_Human1.89227021
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88839291
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86430672
38GATA3_27048872_Chip-Seq_THYMUS_Human1.85557707
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.81782735
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81593481
41* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80013170
42* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.78722135
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74776831
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73179088
45VDR_21846776_ChIP-Seq_THP-1_Human1.71825543
46* NANOG_18555785_Chip-Seq_ESCs_Mouse1.71696039
47CMYC_18555785_Chip-Seq_ESCs_Mouse1.70810645
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.68210504
49P300_19829295_ChIP-Seq_ESCs_Human1.67953204
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67424134
51UTX_26944678_Chip-Seq_JUKART_Human1.65850389
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65627863
53* STAT3_18555785_Chip-Seq_ESCs_Mouse1.65238642
54RUNX1_27457419_Chip-Seq_LIVER_Mouse1.64846528
55ER_23166858_ChIP-Seq_MCF-7_Human1.63299117
56PU_27001747_Chip-Seq_BMDM_Mouse1.61865946
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61593804
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61173812
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61173812
60* P53_22387025_ChIP-Seq_ESCs_Mouse1.59648907
61* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59200635
62SOX2_18555785_Chip-Seq_ESCs_Mouse1.58825194
63* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58628016
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.58445195
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.56527891
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54808948
67GATA1_22025678_ChIP-Seq_K562_Human1.54554900
68P300_18555785_Chip-Seq_ESCs_Mouse1.54317203
69* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53993483
70* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52905049
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52138704
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51819186
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50685944
74* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.50226711
75* FUS_26573619_Chip-Seq_HEK293_Human1.48907737
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.46878472
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42009824
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41870434
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41617532
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.41074047
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40266411
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40154161
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39432786
84KLF4_18555785_Chip-Seq_ESCs_Mouse1.38568990
85* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38553616
86* PU1_27457419_Chip-Seq_LIVER_Mouse1.38239620
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37091027
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36896431
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36367560
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.36094646
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35962874
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35672099
93* NMYC_18555785_Chip-Seq_ESCs_Mouse1.35582744
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34443387
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.34030236
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32967294
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32671274
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.31355661
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.31154279
100VDR_24787735_ChIP-Seq_THP-1_Human1.30900398
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29827212
102STAT3_23295773_ChIP-Seq_U87_Human1.29718490
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29711051
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.28682344
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.28474723
106SMAD4_21799915_ChIP-Seq_A2780_Human1.26789051
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24338796
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24126029
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23942009
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23838110
111* CTCF_18555785_Chip-Seq_ESCs_Mouse1.23106113
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22113598
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21957752
114TCF7_22412390_ChIP-Seq_EML_Mouse1.20706965
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19320762
116MAF_26560356_Chip-Seq_TH2_Human1.18863295
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17905561
118GATA3_26560356_Chip-Seq_TH2_Human1.17089835
119* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12161952
120ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12115186
121TCF4_23295773_ChIP-Seq_U87_Human1.11933866
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11005564
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09990351
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09801209
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09801209
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09801209
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08905506
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07882036
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07800318
130CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07344722
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06341599
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06219287
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05367235
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03129655
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.03067657
136GATA2_21666600_ChIP-Seq_HMVEC_Human1.02455214
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02267026
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01218539
139* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00282676
140CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00085703
141RNF2_27304074_Chip-Seq_NSC_Mouse1.00010910
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99823600
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95458502
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93813180
145EWS_26573619_Chip-Seq_HEK293_Human0.93666935
146* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93547357
147SMRT_27268052_Chip-Seq_Bcells_Human0.93081150
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92671297
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92233963
150SPI1_23547873_ChIP-Seq_NB4_Human0.91840599
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90950199
152KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90879978
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90781402
154SOX2_19829295_ChIP-Seq_ESCs_Human0.90537859
155NANOG_19829295_ChIP-Seq_ESCs_Human0.90537859
156PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90518405
157STAT1_17558387_ChIP-Seq_HELA_Human0.90441014
158GATA2_19941826_ChIP-Seq_K562_Human0.89365711
159VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88285818
160CDX2_22108803_ChIP-Seq_LS180_Human0.88070673
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86855123
162GATA1_19941826_ChIP-Seq_K562_Human0.85470067
163KDM2B_26808549_Chip-Seq_DND41_Human0.84415434
164MYC_22102868_ChIP-Seq_BL_Human0.83623606
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83364455
166KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82531095
167GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80331566
168PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79356115
169SALL4_22934838_ChIP-ChIP_CD34+_Human0.78754992
170GATA3_26560356_Chip-Seq_TH1_Human0.77439197
171* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75451390
172IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72132089
173FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61586544
174GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.61324665
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61285850
176KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.60836000
177SPI1_20517297_ChIP-Seq_HL60_Human0.60816367
178RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.59396277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.67796380
2MP0006082_CNS_inflammation3.24555334
3MP0000920_abnormal_myelination3.14626146
4MP0001800_abnormal_humoral_immune2.83648483
5MP0009785_altered_susceptibility_to2.77398745
6MP0008260_abnormal_autophagy2.71166034
7MP0005171_absent_coat_pigmentation2.59728324
8MP0005310_abnormal_salivary_gland2.55478280
9MP0003950_abnormal_plasma_membrane2.55314653
10MP0003136_yellow_coat_color2.43920944
11MP0003880_abnormal_central_pattern2.43857477
12MP0003191_abnormal_cellular_cholesterol2.34037294
13MP0003690_abnormal_glial_cell2.28652880
14MP0002132_abnormal_respiratory_system2.22530528
15MP0004742_abnormal_vestibular_system2.21177199
16MP0002419_abnormal_innate_immunity2.20169299
17MP0002148_abnormal_hypersensitivity_rea2.18264084
18MP0005058_abnormal_lysosome_morphology2.16442271
19MP0003300_gastrointestinal_ulcer2.07270046
20MP0005464_abnormal_platelet_physiology2.04696890
21MP0001986_abnormal_taste_sensitivity2.04133819
22MP0003172_abnormal_lysosome_physiology2.01180635
23MP0000569_abnormal_digit_pigmentation1.95591020
24MP0003329_amyloid_beta_deposits1.94957740
25MP0001485_abnormal_pinna_reflex1.91995369
26MP0002405_respiratory_system_inflammati1.91729471
27MP0003724_increased_susceptibility_to1.88973341
28MP0004883_abnormal_blood_vessel1.88257022
29MP0001835_abnormal_antigen_presentation1.85506441
30MP0002398_abnormal_bone_marrow1.85500114
31MP0000716_abnormal_immune_system1.83679140
32MP0003195_calcinosis1.81716750
33MP0000465_gastrointestinal_hemorrhage1.79182046
34MP0003303_peritoneal_inflammation1.78837553
35MP0001346_abnormal_lacrimal_gland1.76869984
36MP0003763_abnormal_thymus_physiology1.70407135
37MP0002735_abnormal_chemical_nociception1.69490717
38MP0005025_abnormal_response_to1.66586421
39MP0008877_abnormal_DNA_methylation1.63989962
40MP0004043_abnormal_pH_regulation1.61303456
41MP0002277_abnormal_respiratory_mucosa1.59830930
42MP0003634_abnormal_glial_cell1.59784499
43MP0004381_abnormal_hair_follicle1.59582170
44MP0002064_seizures1.58450650
45MP0000689_abnormal_spleen_morphology1.58213110
46MP0009278_abnormal_bone_marrow1.57120171
47MP0002722_abnormal_immune_system1.56289449
48MP0005451_abnormal_body_composition1.54585444
49MP0001790_abnormal_immune_system1.52721676
50MP0005387_immune_system_phenotype1.52721676
51MP0003436_decreased_susceptibility_to1.52087346
52MP0005000_abnormal_immune_tolerance1.51385896
53MP0004270_analgesia1.50781472
54MP0010155_abnormal_intestine_physiology1.50195083
55MP0002396_abnormal_hematopoietic_system1.47549346
56MP0003866_abnormal_defecation1.46733608
57MP0001501_abnormal_sleep_pattern1.46358026
58MP0001545_abnormal_hematopoietic_system1.45015372
59MP0005397_hematopoietic_system_phenotyp1.45015372
60MP0002876_abnormal_thyroid_physiology1.44333708
61MP0005671_abnormal_response_to1.43815226
62MP0002429_abnormal_blood_cell1.43118345
63MP0001440_abnormal_grooming_behavior1.42539238
64MP0004510_myositis1.42316743
65MP0000383_abnormal_hair_follicle1.39998373
66MP0005164_abnormal_response_to1.39733154
67MP0004885_abnormal_endolymph1.38334522
68MP0001529_abnormal_vocalization1.38215646
69MP0002272_abnormal_nervous_system1.38097931
70MP0009046_muscle_twitch1.37431269
71MP0003787_abnormal_imprinting1.35964120
72MP0001486_abnormal_startle_reflex1.34783708
73MP0000858_altered_metastatic_potential1.32641936
74MP0002166_altered_tumor_susceptibility1.31364647
75MP0003186_abnormal_redox_activity1.31348089
76MP0000703_abnormal_thymus_morphology1.31141380
77MP0004947_skin_inflammation1.28156439
78MP0002229_neurodegeneration1.27120356
79MP0003632_abnormal_nervous_system1.26468901
80MP0010678_abnormal_skin_adnexa1.24258642
81MP0002734_abnormal_mechanical_nocicepti1.23365347
82MP0001905_abnormal_dopamine_level1.22386269
83MP0002736_abnormal_nociception_after1.22238227
84MP0001188_hyperpigmentation1.20862028
85MP0005075_abnormal_melanosome_morpholog1.20268469
86MP0008057_abnormal_DNA_replication1.19615796
87MP0002723_abnormal_immune_serum1.17563639
88MP0000604_amyloidosis1.14936955
89MP0001851_eye_inflammation1.14040997
90MP0001970_abnormal_pain_threshold1.13696950
91MP0001533_abnormal_skeleton_physiology1.12258174
92MP0009333_abnormal_splenocyte_physiolog1.12213247
93MP0003221_abnormal_cardiomyocyte_apopto1.10873715
94MP0004782_abnormal_surfactant_physiolog1.09867535
95MP0000015_abnormal_ear_pigmentation1.09773923
96MP0003631_nervous_system_phenotype1.09104433
97MP0005410_abnormal_fertilization1.06872149
98MP0001968_abnormal_touch/_nociception1.05571962
99MP0001819_abnormal_immune_cell1.03478851
100MP0002452_abnormal_antigen_presenting1.02650977
101MP0002163_abnormal_gland_morphology1.02299058
102MP0005166_decreased_susceptibility_to0.99317710
103MP0002420_abnormal_adaptive_immunity0.98687761
104MP0002998_abnormal_bone_remodeling0.97133794
105MP0004142_abnormal_muscle_tone0.96021262
106MP0005253_abnormal_eye_physiology0.94076919
107MP0003633_abnormal_nervous_system0.93440173
108MP0001764_abnormal_homeostasis0.90679790
109* MP0001845_abnormal_inflammatory_respons0.89946832
110MP0000681_abnormal_thyroid_gland0.88960277
111MP0009745_abnormal_behavioral_response0.88840270
112MP0000778_abnormal_nervous_system0.88419938
113MP0005379_endocrine/exocrine_gland_phen0.87512124
114MP0005551_abnormal_eye_electrophysiolog0.87127856
115MP0003448_altered_tumor_morphology0.87107285
116MP0005645_abnormal_hypothalamus_physiol0.86652759
117MP0002733_abnormal_thermal_nociception0.86345539
118MP0005408_hypopigmentation0.85885563
119MP0001963_abnormal_hearing_physiology0.84400488
120MP0009764_decreased_sensitivity_to0.84378660
121MP0003656_abnormal_erythrocyte_physiolo0.84073302
122MP0003075_altered_response_to0.84043164
123MP0009763_increased_sensitivity_to0.83659489
124MP0001984_abnormal_olfaction0.82557268
125MP0006054_spinal_hemorrhage0.82076737
126MP0002006_tumorigenesis0.81943128
127MP0003828_pulmonary_edema0.79783483
128MP0000343_altered_response_to0.79781804
129MP0004484_altered_response_of0.79457717
130MP0002572_abnormal_emotion/affect_behav0.79157349
131MP0005174_abnormal_tail_pigmentation0.78052537
132MP0005377_hearing/vestibular/ear_phenot0.77371289
133MP0003878_abnormal_ear_physiology0.77371289
134MP0008004_abnormal_stomach_pH0.77194451
135MP0002928_abnormal_bile_duct0.75679169
136MP0000685_abnormal_immune_system0.75650309
137MP0002067_abnormal_sensory_capabilities0.75159349
138MP0001663_abnormal_digestive_system0.74150192
139MP0003718_maternal_effect0.73485565
140MP0003879_abnormal_hair_cell0.72735699
141MP0001853_heart_inflammation0.72699382
142MP0008469_abnormal_protein_level0.72365577
143MP0002063_abnormal_learning/memory/cond0.72094352
144MP0009765_abnormal_xenobiotic_induced0.70630362
145MP0005084_abnormal_gallbladder_morpholo0.70054015
146MP0004808_abnormal_hematopoietic_stem0.68774217
147MP0005390_skeleton_phenotype0.66725579
148MP0005376_homeostasis/metabolism_phenot0.66676209
149MP0008874_decreased_physiological_sensi0.65707547
150MP0002138_abnormal_hepatobiliary_system0.62270892
151MP0003252_abnormal_bile_duct0.60476410
152MP0002133_abnormal_respiratory_system0.59900492
153MP0005388_respiratory_system_phenotype0.59900492
154MP0003806_abnormal_nucleotide_metabolis0.59555636
155MP0000249_abnormal_blood_vessel0.58410367
156MP0002332_abnormal_exercise_endurance0.57546405
157MP0005319_abnormal_enzyme/_coenzyme0.56125268
158MP0003795_abnormal_bone_structure0.55620024
159MP0003045_fibrosis0.54260504
160MP0004130_abnormal_muscle_cell0.52059106

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)6.06683891
2Orchitis (HP:0100796)5.98611793
3Recurrent abscess formation (HP:0002722)5.44479916
4Eczematoid dermatitis (HP:0000976)5.31713950
5Recurrent bacterial skin infections (HP:0005406)4.74519761
6Gastrointestinal infarctions (HP:0005244)4.55801147
7Abnormality of macrophages (HP:0004311)4.50489643
8Recurrent gram-negative bacterial infections (HP:0005420)4.48913835
9Keratoconjunctivitis sicca (HP:0001097)4.44348510
10Parakeratosis (HP:0001036)4.37573514
11Elevated erythrocyte sedimentation rate (HP:0003565)4.34029227
12Keratoconjunctivitis (HP:0001096)4.12501301
13Meningitis (HP:0001287)3.94508024
14Encephalitis (HP:0002383)3.91657814
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.90220303
16Hypochromic microcytic anemia (HP:0004840)3.88611590
17Chronic mucocutaneous candidiasis (HP:0002728)3.81246138
18Recurrent cutaneous fungal infections (HP:0011370)3.81246138
19Chronic obstructive pulmonary disease (HP:0006510)3.74500354
20Obstructive lung disease (HP:0006536)3.74500354
21T lymphocytopenia (HP:0005403)3.67639815
22Spontaneous hematomas (HP:0007420)3.65474994
23Abnormality of T cell number (HP:0011839)3.53952302
24Gingival bleeding (HP:0000225)3.49573404
25Mediastinal lymphadenopathy (HP:0100721)3.48475820
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.47223855
27Peritonitis (HP:0002586)3.38667484
28Abnormal auditory evoked potentials (HP:0006958)3.34203230
29Chest pain (HP:0100749)3.30295489
30Stomatitis (HP:0010280)3.29466274
31Arterial thrombosis (HP:0004420)3.26947094
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.24072561
33Hemoptysis (HP:0002105)3.23742306
34Prolonged bleeding time (HP:0003010)3.23188573
35Neurofibrillary tangles (HP:0002185)3.14107469
36Episodic fever (HP:0001954)3.13637134
37Anorexia (HP:0002039)3.09361148
38Leukocytosis (HP:0001974)3.04102849
39Degeneration of the lateral corticospinal tracts (HP:0002314)3.03164257
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.03164257
41Cerebral hypomyelination (HP:0006808)3.00980999
42Hypochromic anemia (HP:0001931)3.00050309
43Pulmonary infiltrates (HP:0002113)2.96370045
44Cellulitis (HP:0100658)2.96324979
45Prolonged neonatal jaundice (HP:0006579)2.93742794
46Hypoplastic pelvis (HP:0008839)2.89582292
47Pulmonary embolism (HP:0002204)2.88918399
48Gingivitis (HP:0000230)2.88677163
49Epistaxis (HP:0000421)2.81311223
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81273871
51Recurrent skin infections (HP:0001581)2.79687791
52Abnormality of T cells (HP:0002843)2.77795985
53Increased IgE level (HP:0003212)2.76514998
54Hepatosplenomegaly (HP:0001433)2.73462579
55Amyloidosis (HP:0011034)2.67496990
56Gangrene (HP:0100758)2.66989905
57Recurrent viral infections (HP:0004429)2.63625755
58Osteomyelitis (HP:0002754)2.60769320
59Spastic tetraparesis (HP:0001285)2.59205845
60Microcytic anemia (HP:0001935)2.54093120
61Methylmalonic acidemia (HP:0002912)2.50821384
62Segmental peripheral demyelination/remyelination (HP:0003481)2.49925078
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.48567388
64Clumsiness (HP:0002312)2.45216155
65Abnormality of the pleura (HP:0002103)2.44945627
66Granulocytopenia (HP:0001913)2.42358384
67Decreased lacrimation (HP:0000633)2.42356983
68Inflammation of the large intestine (HP:0002037)2.39489335
69Congenital ichthyosiform erythroderma (HP:0007431)2.36786340
70Abnormal ciliary motility (HP:0012262)2.35562401
71Sepsis (HP:0100806)2.35258981
72Abnormality of the peritoneum (HP:0002585)2.35122588
73Increased IgM level (HP:0003496)2.30289672
74Abnormality of glycolipid metabolism (HP:0010969)2.29149185
75Abnormality of liposaccharide metabolism (HP:0010968)2.29149185
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.29149185
77Acute hepatic failure (HP:0006554)2.27977297
78Eosinophilia (HP:0001880)2.27258055
79Split foot (HP:0001839)2.27118994
80Petechiae (HP:0000967)2.26549408
81Abnormal hair whorl (HP:0010721)2.24987578
82Progressive visual loss (HP:0000529)2.24867598
83Hyperventilation (HP:0002883)2.22620077
84Panhypogammaglobulinemia (HP:0003139)2.22306229
85Gastrointestinal inflammation (HP:0004386)2.22225091
86Abnormality of the endocardium (HP:0004306)2.20621010
87Focal motor seizures (HP:0011153)2.18398751
88Subacute progressive viral hepatitis (HP:0006572)2.17987447
89Keratitis (HP:0000491)2.17541684
90Axonal loss (HP:0003447)2.17419170
91Vertigo (HP:0002321)2.15476515
92Basal ganglia calcification (HP:0002135)2.15250178
93Poor speech (HP:0002465)2.11782924
94Abnormality of T cell physiology (HP:0011840)2.11492037
95Methylmalonic aciduria (HP:0012120)2.10054128
96Anhidrosis (HP:0000970)2.09047895
97Epileptic encephalopathy (HP:0200134)2.08995851
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08488038
99Recurrent fungal infections (HP:0002841)2.07969785
100Viral hepatitis (HP:0006562)2.07949810
101Pustule (HP:0200039)2.07569468
102Abnormal respiratory motile cilium physiology (HP:0012261)2.06926622
103Thrombophlebitis (HP:0004418)2.04979295
104Recurrent pneumonia (HP:0006532)2.04926425
105Glomerulopathy (HP:0100820)2.04483388
106Abnormal platelet volume (HP:0011876)2.02296269
107Abnormality of glycolysis (HP:0004366)2.01297962
108Increased serum pyruvate (HP:0003542)2.01297962
109Increased cerebral lipofuscin (HP:0011813)2.00277787
110Conical tooth (HP:0000698)1.99107632
111Skin ulcer (HP:0200042)1.98816169
112Aplasia/hypoplasia of the uterus (HP:0008684)1.97825538
113Peripheral hypomyelination (HP:0007182)1.97799212
114Acne (HP:0001061)1.96030141
115Recurrent bronchitis (HP:0002837)1.95964714
116Cerebral inclusion bodies (HP:0100314)1.94171281
117IgM deficiency (HP:0002850)1.93746512
118Lymphopenia (HP:0001888)1.93547631
119Disinhibition (HP:0000734)1.93445812
120Xerostomia (HP:0000217)1.92959780
121Abnormality of the heme biosynthetic pathway (HP:0010472)1.92850464
122Urticaria (HP:0001025)1.92285736
123Abnormality of eosinophils (HP:0001879)1.92090375
124Hypergammaglobulinemia (HP:0010702)1.90885105
125Slow saccadic eye movements (HP:0000514)1.89848473
126Absent/shortened dynein arms (HP:0200106)1.89596546
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.89596546
128Spastic gait (HP:0002064)1.88845239
129Polyneuropathy (HP:0001271)1.86772334
130Amaurosis fugax (HP:0100576)1.85879716
131Sensory axonal neuropathy (HP:0003390)1.85083852
132Periodontitis (HP:0000704)1.85032158
133Skin rash (HP:0000988)1.84504923
134Abnormality of the corticospinal tract (HP:0002492)1.83795575
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.83742823
136Difficulty running (HP:0009046)1.82394742
137Vacuolated lymphocytes (HP:0001922)1.82016687
138Interstitial pulmonary disease (HP:0006530)1.81552341
139Leukodystrophy (HP:0002415)1.79503751
140Abnormal respiratory motile cilium morphology (HP:0005938)1.79239790
141Abnormal respiratory epithelium morphology (HP:0012253)1.79239790
142Supranuclear gaze palsy (HP:0000605)1.79035287
143Rhinitis (HP:0012384)1.77143547
144Metaphyseal cupping (HP:0003021)1.75906406
145Thickened helices (HP:0000391)1.75286896
146Chronic otitis media (HP:0000389)1.74447667
147Neoplasm of the tracheobronchial system (HP:0100552)1.74386927
148Loss of speech (HP:0002371)1.74242170
149CNS hypomyelination (HP:0003429)1.73202644
150Autoamputation (HP:0001218)1.72823764
151Duplicated collecting system (HP:0000081)1.72363936
152Abnormality of the pericardium (HP:0001697)1.72216977
153Premature loss of primary teeth (HP:0006323)1.70979055
154Hyperphosphatemia (HP:0002905)1.70520924
155Colitis (HP:0002583)1.70481541
156Ankle clonus (HP:0011448)1.69713958
157Stomach cancer (HP:0012126)1.69611800
158Poor head control (HP:0002421)1.69595560
159Thick nail (HP:0001805)1.67813798
160Dysautonomia (HP:0002459)1.67009496
161Cheilitis (HP:0100825)1.66868354
162Hypoplasia of the uterus (HP:0000013)1.64293086
163Pancreatic fibrosis (HP:0100732)1.64060316
1643-Methylglutaconic aciduria (HP:0003535)1.63714824
165Progressive neurologic deterioration (HP:0002344)1.63583606
166Hypokinesia (HP:0002375)1.63314231
167Vasculitis (HP:0002633)1.62479906
168Onion bulb formation (HP:0003383)1.61926571
169Spastic paraparesis (HP:0002313)1.61345152
170Paraparesis (HP:0002385)1.60963088
171Retrobulbar optic neuritis (HP:0100654)1.60675033
172Optic neuritis (HP:0100653)1.60675033
173Progressive inability to walk (HP:0002505)1.60525810
174Genital tract atresia (HP:0001827)1.59810215
175Vaginal atresia (HP:0000148)1.58716500
176Abolished electroretinogram (ERG) (HP:0000550)1.56968077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.75553999
2PBK3.58207252
3CASK3.54457957
4MAP2K33.36437659
5IRAK42.98188142
6MAP3K142.91645001
7EPHB12.83776325
8RIPK42.81426127
9OXSR12.79755366
10MAP4K12.63542780
11FES2.50629221
12GRK62.45046274
13MAPK152.43084885
14AKT32.26136023
15BCR2.21149431
16PNCK2.06293031
17LIMK12.00975628
18MST41.94580444
19PRPF4B1.92234804
20BTK1.91447951
21TNK21.91172756
22ZAP701.90520451
23ERN11.86658559
24JAK31.82849776
25BMPR1B1.78703669
26FGR1.75563202
27SYK1.71738916
28TAOK11.64875967
29JAK21.63924079
30SIK31.58222242
31BMPR21.57991708
32MAP3K61.57910105
33MAP3K31.54469239
34PLK21.51270248
35LYN1.51268169
36WNK41.50957844
37TESK11.48051318
38TAOK31.46909904
39BLK1.46425360
40SGK4941.39140850
41SGK2231.39140850
42WNK11.36322296
43PKN11.35801231
44MAP3K11.33217612
45TEC1.33014795
46MAP3K111.32520811
47KSR21.31679352
48IRAK21.31206503
49IRAK11.28761909
50MAP3K121.25372988
51ARAF1.21512176
52MAP2K41.15022539
53TRPM71.14870441
54CLK11.12819496
55CSK1.09946789
56CSF1R1.06544961
57LCK1.06296993
58ITK1.06077689
59IRAK31.05724480
60YES11.03670263
61LRRK21.03084794
62CCNB11.03075497
63MAP3K51.02218185
64FGFR21.02164092
65IKBKE1.01537920
66PIK3CG1.00827600
67MAP3K130.99446996
68NLK0.98149915
69ACVR1B0.96821750
70KIT0.95409477
71CAMK2B0.94492556
72FGFR30.90867721
73DYRK30.84827798
74BRAF0.83528002
75EPHA30.83159488
76IKBKB0.82467279
77STK100.79269214
78EPHA20.78880221
79PRKCE0.77712825
80TGFBR20.77375188
81KSR10.77001968
82RAF10.76727671
83MAPKAPK50.76517928
84MARK30.76115081
85CDK190.75552763
86PDK10.74535322
87SGK20.73249071
88MET0.73181663
89STK160.72491930
90BUB10.72215677
91PTK60.71661629
92CAMK2D0.70468671
93STK110.70403879
94ERBB30.69413845
95MARK20.68792095
96PIM20.68150471
97TBK10.67126491
98FYN0.66751830
99MAP2K60.66210349
100DYRK1B0.65111814
101WNK30.64466138
102TYK20.63601493
103MAP3K20.61715490
104TXK0.59122520
105STK240.58600913
106CAMKK20.58298592
107PRKCQ0.56799161
108NEK60.56206511
109CAMK2A0.54762931
110MKNK10.54489922
111GRK70.54194935
112MAP2K70.53271439
113STK40.52644462
114PIM10.52220386
115RET0.51797936
116GRK50.51093719
117PRKCD0.50793428
118MKNK20.50491826
119CAMK2G0.50326899
120DAPK20.50099802
121PDPK10.49407161
122NTRK10.48262186
123EIF2AK20.47009615
124EIF2AK30.46166788
125TAOK20.45170735
126ZAK0.43858141
127RPS6KA50.43556365
128SGK30.43365958
129CSNK1A10.42134752
130HIPK20.40454368
131JAK10.37816365
132MAPK70.37216595
133FRK0.37135453
134SGK10.36747937
135ROCK20.36165647
136PLK30.35803093
137PDK30.34924253
138PDK40.34924253
139MYLK0.33951266
140MAPKAPK20.33689649
141DYRK1A0.32405838
142CSNK1A1L0.32063542
143PRKCZ0.30914636
144FGFR40.30804082
145RPS6KA40.30760563
146PDK20.30626646
147MAP3K70.30558586
148PRKD20.30312026
149EPHA40.30031192
150PTK2B0.27729166
151TNIK0.27149167
152ABL20.27085810
153DYRK20.26924459
154EGFR0.26870027
155PRKG10.25950240
156ABL10.25902513
157MATK0.25493198
158TESK20.25169428
159HCK0.24777157

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.96269505
2Steroid biosynthesis_Homo sapiens_hsa001002.81074972
3Rheumatoid arthritis_Homo sapiens_hsa053232.80383948
4Graft-versus-host disease_Homo sapiens_hsa053322.67516502
5Collecting duct acid secretion_Homo sapiens_hsa049662.48890698
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.37893182
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34130382
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32762770
9Vitamin B6 metabolism_Homo sapiens_hsa007502.32021083
10Autoimmune thyroid disease_Homo sapiens_hsa053202.30445658
11Allograft rejection_Homo sapiens_hsa053302.29322076
12B cell receptor signaling pathway_Homo sapiens_hsa046622.26239733
13Leishmaniasis_Homo sapiens_hsa051402.22622627
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.15966548
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08524465
16Asthma_Homo sapiens_hsa053102.02570318
17Ether lipid metabolism_Homo sapiens_hsa005652.02109409
18Fatty acid elongation_Homo sapiens_hsa000621.94079850
19Phagosome_Homo sapiens_hsa041451.89719140
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79402573
21Vibrio cholerae infection_Homo sapiens_hsa051101.79261750
22Lysosome_Homo sapiens_hsa041421.77183185
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76459865
24Primary immunodeficiency_Homo sapiens_hsa053401.72082661
25Proteasome_Homo sapiens_hsa030501.70206276
26Type I diabetes mellitus_Homo sapiens_hsa049401.70130535
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65646729
28African trypanosomiasis_Homo sapiens_hsa051431.64477444
29Sphingolipid metabolism_Homo sapiens_hsa006001.63196435
30Sulfur metabolism_Homo sapiens_hsa009201.56407360
31T cell receptor signaling pathway_Homo sapiens_hsa046601.54628419
32Legionellosis_Homo sapiens_hsa051341.54376777
33Pertussis_Homo sapiens_hsa051331.54040452
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53166756
35Protein export_Homo sapiens_hsa030601.52180795
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.50834744
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47234098
38Acute myeloid leukemia_Homo sapiens_hsa052211.44020073
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.43501908
40Tuberculosis_Homo sapiens_hsa051521.42624892
41Antigen processing and presentation_Homo sapiens_hsa046121.39380269
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.32416045
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30509296
44Non-small cell lung cancer_Homo sapiens_hsa052231.30436972
45Regulation of autophagy_Homo sapiens_hsa041401.26904221
46Platelet activation_Homo sapiens_hsa046111.26565471
47Hepatitis B_Homo sapiens_hsa051611.25846973
48Mineral absorption_Homo sapiens_hsa049781.18992554
49Staphylococcus aureus infection_Homo sapiens_hsa051501.16517826
50Chemokine signaling pathway_Homo sapiens_hsa040621.12176134
51Salmonella infection_Homo sapiens_hsa051321.11709919
52Malaria_Homo sapiens_hsa051441.10150149
53Influenza A_Homo sapiens_hsa051641.10081578
54Phototransduction_Homo sapiens_hsa047441.09106981
55Oxidative phosphorylation_Homo sapiens_hsa001901.08197746
56Viral myocarditis_Homo sapiens_hsa054161.07283421
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02596050
58Synaptic vesicle cycle_Homo sapiens_hsa047211.01497759
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00686780
60Pancreatic cancer_Homo sapiens_hsa052120.98034862
61Arachidonic acid metabolism_Homo sapiens_hsa005900.96029786
62Vitamin digestion and absorption_Homo sapiens_hsa049770.91975291
63Prolactin signaling pathway_Homo sapiens_hsa049170.90754162
64Apoptosis_Homo sapiens_hsa042100.85899030
65Osteoclast differentiation_Homo sapiens_hsa043800.85627896
66FoxO signaling pathway_Homo sapiens_hsa040680.82924879
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81136709
68Serotonergic synapse_Homo sapiens_hsa047260.80115322
69Basal transcription factors_Homo sapiens_hsa030220.79813516
70TNF signaling pathway_Homo sapiens_hsa046680.79718106
71Shigellosis_Homo sapiens_hsa051310.79280049
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.78435862
73Dorso-ventral axis formation_Homo sapiens_hsa043200.78225287
74VEGF signaling pathway_Homo sapiens_hsa043700.78018896
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75202351
76Histidine metabolism_Homo sapiens_hsa003400.74708078
77Herpes simplex infection_Homo sapiens_hsa051680.74567427
78Chronic myeloid leukemia_Homo sapiens_hsa052200.74089882
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72613146
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.71926463
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71715900
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70785714
83Hepatitis C_Homo sapiens_hsa051600.70095699
84Endocytosis_Homo sapiens_hsa041440.66809658
85Morphine addiction_Homo sapiens_hsa050320.66324619
86Endometrial cancer_Homo sapiens_hsa052130.65758077
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65649410
88Measles_Homo sapiens_hsa051620.64201853
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63007730
90HIF-1 signaling pathway_Homo sapiens_hsa040660.62178839
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.59795737
92Linoleic acid metabolism_Homo sapiens_hsa005910.58307445
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57857008
94Glutathione metabolism_Homo sapiens_hsa004800.57732910
95Folate biosynthesis_Homo sapiens_hsa007900.56807581
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56685260
97Amoebiasis_Homo sapiens_hsa051460.56328483
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55852096
99Viral carcinogenesis_Homo sapiens_hsa052030.54851390
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.53996379
101Choline metabolism in cancer_Homo sapiens_hsa052310.53309199
102GnRH signaling pathway_Homo sapiens_hsa049120.52185402
103Toxoplasmosis_Homo sapiens_hsa051450.51844676
104Renal cell carcinoma_Homo sapiens_hsa052110.51689958
105Alzheimers disease_Homo sapiens_hsa050100.51473550
106Notch signaling pathway_Homo sapiens_hsa043300.51025510
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50141717
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.49782546
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48688630
110mTOR signaling pathway_Homo sapiens_hsa041500.48183726
111Other glycan degradation_Homo sapiens_hsa005110.47920216
112Prion diseases_Homo sapiens_hsa050200.47615919
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47460175
114Glutamatergic synapse_Homo sapiens_hsa047240.47408147
115Type II diabetes mellitus_Homo sapiens_hsa049300.47153831
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47045526
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45339245
118Pentose phosphate pathway_Homo sapiens_hsa000300.44450816
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43765031
120Insulin resistance_Homo sapiens_hsa049310.43077582
121Colorectal cancer_Homo sapiens_hsa052100.42561284
122Rap1 signaling pathway_Homo sapiens_hsa040150.41709239
123GABAergic synapse_Homo sapiens_hsa047270.40598893
124Prostate cancer_Homo sapiens_hsa052150.40467776
125RNA polymerase_Homo sapiens_hsa030200.40226203
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38844073
127Inositol phosphate metabolism_Homo sapiens_hsa005620.38229479
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.37688202
129MAPK signaling pathway_Homo sapiens_hsa040100.37072707
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36894499
131Epstein-Barr virus infection_Homo sapiens_hsa051690.36274379
132Long-term potentiation_Homo sapiens_hsa047200.35945010
133Parkinsons disease_Homo sapiens_hsa050120.35751604
134Nicotine addiction_Homo sapiens_hsa050330.35366938
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34245293
136Olfactory transduction_Homo sapiens_hsa047400.34222607
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32073219
138Pancreatic secretion_Homo sapiens_hsa049720.29811552
139ErbB signaling pathway_Homo sapiens_hsa040120.29763810
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29022102
141Glioma_Homo sapiens_hsa052140.28816832
142Long-term depression_Homo sapiens_hsa047300.28804992
143Hematopoietic cell lineage_Homo sapiens_hsa046400.28584629
144Tight junction_Homo sapiens_hsa045300.28159903
145Salivary secretion_Homo sapiens_hsa049700.27889451
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27812306
147Axon guidance_Homo sapiens_hsa043600.27644022

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