GCAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.50570619
2L-phenylalanine metabolic process (GO:0006558)6.50570619
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.46027338
4L-phenylalanine catabolic process (GO:0006559)6.46027338
5intestinal cholesterol absorption (GO:0030299)5.94002663
6serine family amino acid biosynthetic process (GO:0009070)5.82704846
7cysteine metabolic process (GO:0006534)5.67541998
8aromatic amino acid family catabolic process (GO:0009074)5.28725130
9* glycine metabolic process (GO:0006544)5.19331627
10L-serine metabolic process (GO:0006563)5.07506175
11serine family amino acid catabolic process (GO:0009071)5.05457964
12glyoxylate metabolic process (GO:0046487)4.96247634
13sulfur amino acid catabolic process (GO:0000098)4.93893107
14homocysteine metabolic process (GO:0050667)4.86928536
15* serine family amino acid metabolic process (GO:0009069)4.85417971
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.60080156
17regulation of mitochondrial translation (GO:0070129)4.44861956
18kynurenine metabolic process (GO:0070189)4.39714336
19indole-containing compound catabolic process (GO:0042436)4.36016810
20indolalkylamine catabolic process (GO:0046218)4.36016810
21tryptophan catabolic process (GO:0006569)4.36016810
22bile acid biosynthetic process (GO:0006699)4.35839191
23telomere maintenance via semi-conservative replication (GO:0032201)4.34464951
24cellular modified amino acid catabolic process (GO:0042219)4.23650383
25tryptophan metabolic process (GO:0006568)4.18826122
26proline biosynthetic process (GO:0006561)4.17917654
27lysine catabolic process (GO:0006554)4.14504065
28lysine metabolic process (GO:0006553)4.14504065
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.10208517
30DNA strand elongation involved in DNA replication (GO:0006271)4.08434992
31aromatic amino acid family metabolic process (GO:0009072)4.05688157
32* alpha-amino acid catabolic process (GO:1901606)4.04938681
33urea cycle (GO:0000050)4.04045606
34urea metabolic process (GO:0019627)4.04045606
35branched-chain amino acid catabolic process (GO:0009083)4.00684610
36high-density lipoprotein particle remodeling (GO:0034375)3.97892509
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96496587
38negative regulation of fibrinolysis (GO:0051918)3.94365857
39DNA strand elongation (GO:0022616)3.92327209
40exocrine pancreas development (GO:0031017)3.92281545
41* cellular amino acid catabolic process (GO:0009063)3.91863529
42proteasome assembly (GO:0043248)3.89770133
43proline metabolic process (GO:0006560)3.85898077
44imidazole-containing compound metabolic process (GO:0052803)3.84888149
45nitrogen cycle metabolic process (GO:0071941)3.81642805
46oxidative phosphorylation (GO:0006119)3.80807801
47tetrahydrofolate metabolic process (GO:0046653)3.74154668
48one-carbon metabolic process (GO:0006730)3.73380269
49alpha-linolenic acid metabolic process (GO:0036109)3.72871990
50peptidyl-glutamic acid carboxylation (GO:0017187)3.70849758
51protein carboxylation (GO:0018214)3.70849758
52bile acid metabolic process (GO:0008206)3.70754262
53regulation of fibrinolysis (GO:0051917)3.70176432
54amino-acid betaine metabolic process (GO:0006577)3.69354681
55folic acid-containing compound biosynthetic process (GO:0009396)3.67652268
56coenzyme catabolic process (GO:0009109)3.63118068
57sulfur amino acid biosynthetic process (GO:0000097)3.60689350
58intestinal absorption (GO:0050892)3.59093105
59aldehyde catabolic process (GO:0046185)3.54763004
60branched-chain amino acid metabolic process (GO:0009081)3.52178253
61telomere maintenance via recombination (GO:0000722)3.51630273
62negative regulation of sterol transport (GO:0032372)3.51110850
63negative regulation of cholesterol transport (GO:0032375)3.51110850
64regulation of protein activation cascade (GO:2000257)3.49766807
65valine metabolic process (GO:0006573)3.49551799
66pteridine-containing compound biosynthetic process (GO:0042559)3.48391600
67glutamine family amino acid biosynthetic process (GO:0009084)3.47084580
68alpha-amino acid biosynthetic process (GO:1901607)3.46837637
69folic acid metabolic process (GO:0046655)3.43997551
70regulation of cholesterol esterification (GO:0010872)3.43781291
71reverse cholesterol transport (GO:0043691)3.42730082
72mitotic recombination (GO:0006312)3.42117861
73tyrosine metabolic process (GO:0006570)3.40539433
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38454429
75ATP synthesis coupled proton transport (GO:0015986)3.36463774
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36463774
77* carboxylic acid catabolic process (GO:0046395)3.36094462
78* organic acid catabolic process (GO:0016054)3.36094462
79rRNA modification (GO:0000154)3.35348346
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34359895
81pseudouridine synthesis (GO:0001522)3.34238126
82acylglycerol homeostasis (GO:0055090)3.33797381
83triglyceride homeostasis (GO:0070328)3.33797381
84glutamate metabolic process (GO:0006536)3.32837546
85complement activation, alternative pathway (GO:0006957)3.32001637
86sterol catabolic process (GO:0016127)3.29733712
87cholesterol catabolic process (GO:0006707)3.29733712
88plasma lipoprotein particle remodeling (GO:0034369)3.28101487
89protein-lipid complex remodeling (GO:0034368)3.28101487
90macromolecular complex remodeling (GO:0034367)3.28101487
91folic acid-containing compound metabolic process (GO:0006760)3.27552275
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26095555
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24847020
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24334606
95ethanol oxidation (GO:0006069)3.23367382
96regulation of triglyceride catabolic process (GO:0010896)3.23146507
97regulation of complement activation (GO:0030449)3.22890123
98response to nitrosative stress (GO:0051409)3.20823492
99cellular amino acid biosynthetic process (GO:0008652)3.20254671
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.19968952
101sulfur amino acid metabolic process (GO:0000096)3.17966113
102establishment of integrated proviral latency (GO:0075713)3.17059000
103positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16568820
104pteridine-containing compound metabolic process (GO:0042558)3.15424366
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.15074152
106DNA replication checkpoint (GO:0000076)3.12951151
107phospholipid efflux (GO:0033700)3.12885230
108digestion (GO:0007586)3.12540631
109negative regulation of ligase activity (GO:0051352)3.10328635
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10328635
111plasma lipoprotein particle clearance (GO:0034381)3.09942076
112formation of translation preinitiation complex (GO:0001731)3.07935094
113indolalkylamine metabolic process (GO:0006586)3.07503519
114cellular ketone body metabolic process (GO:0046950)3.07475588
115cellular biogenic amine catabolic process (GO:0042402)3.07142189
116amine catabolic process (GO:0009310)3.07142189
117establishment of protein localization to mitochondrial membrane (GO:0090151)3.06924622
118protein maturation by protein folding (GO:0022417)3.06013318
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04523704
120CENP-A containing nucleosome assembly (GO:0034080)3.04452277
121short-chain fatty acid metabolic process (GO:0046459)3.04390436
1224-hydroxyproline metabolic process (GO:0019471)3.03920445
123bile acid and bile salt transport (GO:0015721)3.03694797
124deoxyribose phosphate biosynthetic process (GO:0046385)3.03688021
1252-deoxyribonucleotide biosynthetic process (GO:0009265)3.03688021
126benzene-containing compound metabolic process (GO:0042537)3.03390120
127protein retention in ER lumen (GO:0006621)3.02829845
128tRNA aminoacylation for protein translation (GO:0006418)3.00940083
129chromatin remodeling at centromere (GO:0031055)3.00662758
130telomere maintenance via telomere lengthening (GO:0010833)3.00329030
131* alpha-amino acid metabolic process (GO:1901605)3.00133533
132transcription-coupled nucleotide-excision repair (GO:0006283)2.98450654
133respiratory electron transport chain (GO:0022904)2.97864964
134ribosomal large subunit biogenesis (GO:0042273)2.97715998
135* aspartate family amino acid catabolic process (GO:0009068)2.97626797
136cullin deneddylation (GO:0010388)2.97054094
137heme transport (GO:0015886)2.96145024
138cholesterol homeostasis (GO:0042632)2.95839873
139protein targeting to mitochondrion (GO:0006626)2.95809444
140cellular glucuronidation (GO:0052695)2.95623622
141tricarboxylic acid cycle (GO:0006099)2.93952260
142DNA unwinding involved in DNA replication (GO:0006268)2.92943704
143mitotic metaphase plate congression (GO:0007080)2.92364015
144deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.91626773
145mitotic sister chromatid segregation (GO:0000070)2.91154464
146DNA replication initiation (GO:0006270)2.90961192
147protein complex biogenesis (GO:0070271)2.90628664
148regulation of cellular amino acid metabolic process (GO:0006521)2.90539200
149tRNA aminoacylation (GO:0043039)2.89741255
150amino acid activation (GO:0043038)2.89741255
151electron transport chain (GO:0022900)2.89462928
152positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85974439
153mitochondrial respiratory chain complex assembly (GO:0033108)2.85450505
154chaperone-mediated protein transport (GO:0072321)2.83896039
155regulation of translational fidelity (GO:0006450)2.83725156
156purine nucleobase biosynthetic process (GO:0009113)2.83065965
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.82352083
158iron-sulfur cluster assembly (GO:0016226)2.82055444
159metallo-sulfur cluster assembly (GO:0031163)2.82055444
160peptidyl-histidine modification (GO:0018202)2.81798130
161heme biosynthetic process (GO:0006783)2.81427887
162pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.81181868
163kinetochore assembly (GO:0051382)2.80878176
164establishment of viral latency (GO:0019043)2.78070096
165mitochondrial respiratory chain complex I assembly (GO:0032981)2.77671384
166NADH dehydrogenase complex assembly (GO:0010257)2.77671384
167mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77671384
168DNA ligation (GO:0006266)2.77649867
169ribosome assembly (GO:0042255)2.77446398
170ubiquinone biosynthetic process (GO:0006744)2.77230855
171base-excision repair (GO:0006284)2.76813539
172nucleobase biosynthetic process (GO:0046112)2.75682993
173DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75665954
174signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75593545
175signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75593545
176signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75593545
177base-excision repair, AP site formation (GO:0006285)2.74764061
178deoxyribonucleotide biosynthetic process (GO:0009263)2.74420262
179RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74020319
180tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74020319
181protein deneddylation (GO:0000338)2.73520389
182signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72666144
183signal transduction involved in DNA damage checkpoint (GO:0072422)2.72666144
184intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72195901
185signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72195901
186respiratory chain complex IV assembly (GO:0008535)2.71207073
187positive regulation of ligase activity (GO:0051351)2.70978019
188establishment of protein localization to mitochondrion (GO:0072655)2.70701385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.76528526
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.58263186
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.19413269
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.74561841
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63849392
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.23138108
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.22685701
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.06759158
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94882034
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89321291
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.86798107
12E2F7_22180533_ChIP-Seq_HELA_Human2.86630574
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49308411
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32199538
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26599326
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22885282
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19246014
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18400106
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15455037
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11685321
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07214459
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.03483049
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02979042
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.97164333
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94312443
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.88020960
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86184836
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85249430
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77834393
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.77556715
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63049350
32XRN2_22483619_ChIP-Seq_HELA_Human1.61676768
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59560027
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57584251
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56681454
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.55315978
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55165682
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54745173
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52035625
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51616766
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50597190
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46311424
43DCP1A_22483619_ChIP-Seq_HELA_Human1.45973758
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45935911
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44332361
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43127341
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41751732
48* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41717116
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41085832
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.39437166
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39235249
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39235249
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39235249
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34921400
55AR_21909140_ChIP-Seq_LNCAP_Human1.33491023
56GABP_19822575_ChIP-Seq_HepG2_Human1.30927301
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28912101
58ELK1_19687146_ChIP-ChIP_HELA_Human1.27045336
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25348952
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23305674
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22709783
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22522830
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21900073
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21469714
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18579445
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.18393063
67FOXP3_21729870_ChIP-Seq_TREG_Human1.17574170
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17186572
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16646343
70SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16300649
71VDR_23849224_ChIP-Seq_CD4+_Human1.16034976
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14485828
73* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13926991
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12769192
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11672972
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10064065
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.09735420
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09606238
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09306510
80* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08946733
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08877173
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08242603
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06818225
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04093323
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.03067092
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02921321
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02861113
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01905616
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01496686
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00071547
91RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98754753
92* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98693754
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98473971
94* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98442407
95TTF2_22483619_ChIP-Seq_HELA_Human0.98338971
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98268664
97KDM5A_27292631_Chip-Seq_BREAST_Human0.97471334
98* MYC_18940864_ChIP-ChIP_HL60_Human0.97140623
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96642979
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95468504
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94677006
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94587811
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94516579
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90027673
105CLOCK_20551151_ChIP-Seq_293T_Human0.89618042
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88020045
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87965756
108GATA4_25053715_ChIP-Seq_YYC3_Human0.86902134
109* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86273281
110TFEB_21752829_ChIP-Seq_HELA_Human0.85841524
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84620866
112TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84460576
113CIITA_25753668_ChIP-Seq_RAJI_Human0.84408316
114* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84349393
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83698431
116ZNF263_19887448_ChIP-Seq_K562_Human0.83407895
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82680519
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82470582
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81901380
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79591384
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78708650
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78517306
123* FOXP1_21924763_ChIP-Seq_HESCs_Human0.78282984
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.77793891
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77745817
126* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77648786
127GATA6_25053715_ChIP-Seq_YYC3_Human0.77498428
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76753522
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.76447076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.32068369
2MP0005365_abnormal_bile_salt6.04727584
3MP0005360_urolithiasis5.79186254
4MP0005085_abnormal_gallbladder_physiolo5.47476675
5MP0003806_abnormal_nucleotide_metabolis4.91644448
6MP0005083_abnormal_biliary_tract4.79743562
7MP0001666_abnormal_nutrient_absorption4.38598608
8MP0008875_abnormal_xenobiotic_pharmacok3.50606290
9MP0009840_abnormal_foam_cell2.73386487
10MP0003252_abnormal_bile_duct2.71270025
11MP0005332_abnormal_amino_acid2.70463982
12MP0000372_irregular_coat_pigmentation2.68371510
13MP0005220_abnormal_exocrine_pancreas2.68184885
14MP0010329_abnormal_lipoprotein_level2.55523117
15MP0003868_abnormal_feces_composition2.17236511
16MP0003195_calcinosis2.14079631
17MP0003786_premature_aging2.13350934
18MP0006292_abnormal_olfactory_placode2.09967221
19MP0004019_abnormal_vitamin_homeostasis1.95410129
20MP0002822_catalepsy1.91109854
21MP0003136_yellow_coat_color1.87676672
22MP0004233_abnormal_muscle_weight1.80198311
23MP0008007_abnormal_cellular_replicative1.78396488
24MP0003705_abnormal_hypodermis_morpholog1.77847760
25MP0001764_abnormal_homeostasis1.77584485
26MP0004147_increased_porphyrin_level1.77342149
27MP0003186_abnormal_redox_activity1.76370994
28MP0002118_abnormal_lipid_homeostasis1.71485953
29MP0000609_abnormal_liver_physiology1.64821584
30MP0005171_absent_coat_pigmentation1.64511285
31MP0005084_abnormal_gallbladder_morpholo1.59234669
32MP0005451_abnormal_body_composition1.59169995
33MP0005319_abnormal_enzyme/_coenzyme1.50310258
34MP0001529_abnormal_vocalization1.48839323
35MP0003693_abnormal_embryo_hatching1.48739513
36MP0000358_abnormal_cell_content/1.46368702
37MP0009643_abnormal_urine_homeostasis1.44860243
38MP0003191_abnormal_cellular_cholesterol1.42321623
39MP0003011_delayed_dark_adaptation1.37074508
40MP0002796_impaired_skin_barrier1.33799218
41MP0002938_white_spotting1.33523668
42MP0003646_muscle_fatigue1.32676502
43MP0002138_abnormal_hepatobiliary_system1.29494770
44MP0004957_abnormal_blastocyst_morpholog1.28924675
45MP0001697_abnormal_embryo_size1.21437803
46MP0001293_anophthalmia1.21318261
47MP0006036_abnormal_mitochondrial_physio1.19052582
48MP0003718_maternal_effect1.17179705
49MP0002234_abnormal_pharynx_morphology1.16669326
50MP0000598_abnormal_liver_morphology1.15953197
51MP0005408_hypopigmentation1.13493480
52MP0004264_abnormal_extraembryonic_tissu1.12223109
53MP0001929_abnormal_gametogenesis1.12149963
54MP0002736_abnormal_nociception_after1.11987304
55MP0000350_abnormal_cell_proliferation1.11588534
56MP0008260_abnormal_autophagy1.10256475
57MP0005330_cardiomyopathy1.06605882
58MP0002210_abnormal_sex_determination1.04701972
59MP0001672_abnormal_embryogenesis/_devel1.01383180
60MP0005380_embryogenesis_phenotype1.01383180
61MP0002254_reproductive_system_inflammat0.98278697
62MP0002160_abnormal_reproductive_system0.97543852
63MP0000751_myopathy0.97094516
64MP0008789_abnormal_olfactory_epithelium0.95373092
65MP0000653_abnormal_sex_gland0.95069145
66MP0005584_abnormal_enzyme/coenzyme_acti0.92845193
67MP0001145_abnormal_male_reproductive0.92599264
68MP0010030_abnormal_orbit_morphology0.92359325
69MP0008995_early_reproductive_senescence0.91692655
70MP0000749_muscle_degeneration0.88607935
71MP0005501_abnormal_skin_physiology0.88134451
72MP0000313_abnormal_cell_death0.88109988
73MP0003315_abnormal_perineum_morphology0.87573653
74MP0004133_heterotaxia0.87146708
75MP0005410_abnormal_fertilization0.86289428
76MP0005636_abnormal_mineral_homeostasis0.85866321
77MP0009053_abnormal_anal_canal0.85786015
78MP0009697_abnormal_copulation0.85685418
79MP0002132_abnormal_respiratory_system0.85384764
80MP0003698_abnormal_male_reproductive0.85229821
81MP0009765_abnormal_xenobiotic_induced0.84467318
82MP0002269_muscular_atrophy0.83739388
83MP0003638_abnormal_response/metabolism_0.82675618
84MP0005646_abnormal_pituitary_gland0.80827882
85MP0003111_abnormal_nucleus_morphology0.80706891
86MP0003984_embryonic_growth_retardation0.80578636
87MP0002098_abnormal_vibrissa_morphology0.78889651
88MP0002085_abnormal_embryonic_tissue0.78760407
89MP0002161_abnormal_fertility/fecundity0.76488265
90MP0000678_abnormal_parathyroid_gland0.76407295
91MP0001944_abnormal_pancreas_morphology0.76051102
92MP0002088_abnormal_embryonic_growth/wei0.75763810
93MP0005075_abnormal_melanosome_morpholog0.75695089
94MP0005266_abnormal_metabolism0.75652242
95MP0006035_abnormal_mitochondrial_morpho0.75409757
96MP0002693_abnormal_pancreas_physiology0.75016107
97MP0009672_abnormal_birth_weight0.74987091
98MP0003283_abnormal_digestive_organ0.74906082
99MP0010234_abnormal_vibrissa_follicle0.74892207
100MP0002078_abnormal_glucose_homeostasis0.71252933
101MP0009763_increased_sensitivity_to0.71022544
102MP0003567_abnormal_fetal_cardiomyocyte0.70029224
103MP0001756_abnormal_urination0.69307779
104MP0002084_abnormal_developmental_patter0.69168199
105MP0003937_abnormal_limbs/digits/tail_de0.67583320
106MP0009379_abnormal_foot_pigmentation0.67062712
107MP0003077_abnormal_cell_cycle0.66590495
108MP0003959_abnormal_lean_body0.66355111
109MP0002060_abnormal_skin_morphology0.65934698
110MP0009642_abnormal_blood_homeostasis0.65752028
111MP0010094_abnormal_chromosome_stability0.64976327
112MP0000566_synostosis0.64901654
113MP0005647_abnormal_sex_gland0.64776958
114MP0005376_homeostasis/metabolism_phenot0.64701893
115MP0001119_abnormal_female_reproductive0.64655697
116MP0003699_abnormal_female_reproductive0.64634167
117MP0000015_abnormal_ear_pigmentation0.64526907
118MP0005377_hearing/vestibular/ear_phenot0.63278800
119MP0003878_abnormal_ear_physiology0.63278800
120MP0003137_abnormal_impulse_conducting0.61918610
121MP0004145_abnormal_muscle_electrophysio0.61755663
122MP0000579_abnormal_nail_morphology0.61485633
123MP0002090_abnormal_vision0.60918357
124MP0004381_abnormal_hair_follicle0.59339468
125MP0005499_abnormal_olfactory_system0.59146049
126MP0005394_taste/olfaction_phenotype0.59146049
127MP0003941_abnormal_skin_development0.58650115
128MP0003453_abnormal_keratinocyte_physiol0.58512796
129MP0001730_embryonic_growth_arrest0.58459534
130MP0003119_abnormal_digestive_system0.58289647
131MP0001727_abnormal_embryo_implantation0.58175010
132MP0002019_abnormal_tumor_incidence0.57666679
133MP0005448_abnormal_energy_balance0.56209996
134MP0008469_abnormal_protein_level0.55650969
135MP0000377_abnormal_hair_follicle0.55258724
136MP0003656_abnormal_erythrocyte_physiolo0.54775044
137MP0005395_other_phenotype0.54005977
138MP0000467_abnormal_esophagus_morphology0.53041990
139MP0001216_abnormal_epidermal_layer0.52439969
140MP0008932_abnormal_embryonic_tissue0.52233391
141MP0003890_abnormal_embryonic-extraembry0.50721394
142MP0001243_abnormal_dermal_layer0.49407243
143MP0005670_abnormal_white_adipose0.49121988
144MP0010352_gastrointestinal_tract_polyps0.48844876
145MP0000647_abnormal_sebaceous_gland0.47738972
146MP0003123_paternal_imprinting0.46861429
147MP0002249_abnormal_larynx_morphology0.46580711
148MP0004043_abnormal_pH_regulation0.46262486
149MP0008058_abnormal_DNA_repair0.45287502
150MP0000367_abnormal_coat/_hair0.44239096
151MP0001661_extended_life_span0.43971514
152MP0002136_abnormal_kidney_physiology0.43632769
153MP0005023_abnormal_wound_healing0.43424435
154MP0008873_increased_physiological_sensi0.42430729
155MP0000613_abnormal_salivary_gland0.42015923
156MP0002111_abnormal_tail_morphology0.41542742
157MP0003953_abnormal_hormone_level0.38285852
158MP0002080_prenatal_lethality0.37571603
159MP0009931_abnormal_skin_appearance0.36701397

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.88326792
2Intrahepatic cholestasis (HP:0001406)5.98545344
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.86950053
4Hypobetalipoproteinemia (HP:0003563)5.57613047
5Deep venous thrombosis (HP:0002625)5.03225225
6Hyperglycinemia (HP:0002154)4.84346910
7Xanthomatosis (HP:0000991)4.81565194
8Hyperglycinuria (HP:0003108)4.49976042
9Fat malabsorption (HP:0002630)4.48033385
10Prolonged partial thromboplastin time (HP:0003645)4.46078896
11Abnormal mitochondria in muscle tissue (HP:0008316)4.42031261
12Abnormality of glycine metabolism (HP:0010895)4.36810219
13Abnormality of serine family amino acid metabolism (HP:0010894)4.36810219
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.36309048
15Hyperammonemia (HP:0001987)4.34870897
16Acute necrotizing encephalopathy (HP:0006965)4.30364590
17Abnormality of methionine metabolism (HP:0010901)4.29870475
18Ketosis (HP:0001946)4.24788163
19Hypoglycemic coma (HP:0001325)4.17381910
20Abnormality of pyrimidine metabolism (HP:0004353)4.16207227
21Hepatocellular necrosis (HP:0001404)4.12109862
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06310927
23Steatorrhea (HP:0002570)3.94500503
24Hypolipoproteinemia (HP:0010981)3.90666319
25Increased CSF lactate (HP:0002490)3.78483996
26Mitochondrial inheritance (HP:0001427)3.77998267
27Hyperlipoproteinemia (HP:0010980)3.74616185
28Abnormality of the intrinsic pathway (HP:0010989)3.72125017
29Microvesicular hepatic steatosis (HP:0001414)3.60255100
30Abnormality of the common coagulation pathway (HP:0010990)3.52562442
31Abnormality of serum amino acid levels (HP:0003112)3.38303904
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.37780865
33Abnormal gallbladder physiology (HP:0012438)3.36448650
34Cholecystitis (HP:0001082)3.36448650
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.35496276
36Delayed CNS myelination (HP:0002188)3.31077606
37Ketoacidosis (HP:0001993)3.27896243
38Progressive macrocephaly (HP:0004481)3.27550737
39Gout (HP:0001997)3.25142785
40Increased serum lactate (HP:0002151)3.21136537
41Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19738072
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19738072
43Type I transferrin isoform profile (HP:0003642)3.11856666
44Lethargy (HP:0001254)3.07358882
45Complement deficiency (HP:0004431)3.06846626
46Abnormality of fatty-acid metabolism (HP:0004359)3.06284482
47Epidermoid cyst (HP:0200040)3.02076347
48Hypoalphalipoproteinemia (HP:0003233)2.99805170
49Increased intramyocellular lipid droplets (HP:0012240)2.99722374
50Cerebral edema (HP:0002181)2.99465127
51Dicarboxylic aciduria (HP:0003215)2.99394491
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.99394491
53Ragged-red muscle fibers (HP:0003200)2.98759293
54Abnormality of nucleobase metabolism (HP:0010932)2.95703221
55Joint hemorrhage (HP:0005261)2.91113091
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89688096
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88904205
58Exercise intolerance (HP:0003546)2.81526536
59Late onset (HP:0003584)2.80890802
60Conjugated hyperbilirubinemia (HP:0002908)2.72863906
61Lipid accumulation in hepatocytes (HP:0006561)2.72219326
62Hypoglycemic seizures (HP:0002173)2.71721151
63Increased muscle lipid content (HP:0009058)2.70589158
64Spastic diplegia (HP:0001264)2.70508391
65Increased hepatocellular lipid droplets (HP:0006565)2.68276274
66Cerebral hypomyelination (HP:0006808)2.65710002
67Abnormal protein glycosylation (HP:0012346)2.65362830
68Abnormal glycosylation (HP:0012345)2.65362830
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65362830
70Abnormal protein N-linked glycosylation (HP:0012347)2.65362830
71Megaloblastic anemia (HP:0001889)2.62364822
72Hyperbilirubinemia (HP:0002904)2.59506971
73Hyperinsulinemic hypoglycemia (HP:0000825)2.58481196
74Respiratory failure (HP:0002878)2.57003303
75Birth length less than 3rd percentile (HP:0003561)2.56605529
76Hypercholesterolemia (HP:0003124)2.53851131
77Generalized aminoaciduria (HP:0002909)2.52791002
78Metabolic acidosis (HP:0001942)2.51533428
79Opisthotonus (HP:0002179)2.46651003
80Pancreatitis (HP:0001733)2.46599348
81Abnormality of complement system (HP:0005339)2.44469704
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37975267
83Abnormality of purine metabolism (HP:0004352)2.35451218
84Malnutrition (HP:0004395)2.35440729
85Cholelithiasis (HP:0001081)2.34027358
86Renal Fanconi syndrome (HP:0001994)2.34013883
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32361438
88Abnormality of alanine metabolism (HP:0010916)2.32361438
89Hyperalaninemia (HP:0003348)2.32361438
90Abnormal number of erythroid precursors (HP:0012131)2.29444837
91Chromsome breakage (HP:0040012)2.28973552
92Microretrognathia (HP:0000308)2.23910585
93Hypokinesia (HP:0002375)2.23274109
94Abnormal cartilage morphology (HP:0002763)2.22914580
95Abnormality of endocrine pancreas physiology (HP:0012093)2.22274881
96Abnormality of the pancreatic islet cells (HP:0006476)2.22274881
97Testicular atrophy (HP:0000029)2.20646720
98Hepatic necrosis (HP:0002605)2.19103346
99Hepatocellular carcinoma (HP:0001402)2.18313839
100Irritability (HP:0000737)2.17348428
101Vascular calcification (HP:0004934)2.16979615
102Hypoplastic pelvis (HP:0008839)2.14647412
103Emotional lability (HP:0000712)2.14137074
104Leukodystrophy (HP:0002415)2.12546655
105Macrocytic anemia (HP:0001972)2.12325854
106Oral leukoplakia (HP:0002745)2.11932934
107Multiple enchondromatosis (HP:0005701)2.11468173
108Proximal tubulopathy (HP:0000114)2.10113516
109Abnormality of cells of the erythroid lineage (HP:0012130)2.09613945
110Hyperthyroidism (HP:0000836)2.09392603
111Vomiting (HP:0002013)2.08798222
112Meckel diverticulum (HP:0002245)2.07498558
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06726153
114Type I diabetes mellitus (HP:0100651)2.04803700
115Premature ovarian failure (HP:0008209)2.04287464
116Acute encephalopathy (HP:0006846)2.04135723
117Abnormality of the preputium (HP:0100587)2.03649143
118Abnormality of the heme biosynthetic pathway (HP:0010472)2.03003729
119Respiratory difficulties (HP:0002880)2.01749064
120Aplasia/Hypoplasia of the uvula (HP:0010293)2.00601105
121Glycosuria (HP:0003076)2.00296556
122Abnormality of urine glucose concentration (HP:0011016)2.00296556
1233-Methylglutaconic aciduria (HP:0003535)1.99427099
124Abnormality of glycolysis (HP:0004366)1.99028216
125Increased serum pyruvate (HP:0003542)1.99028216
126Cerebral palsy (HP:0100021)1.98937247
127Reticulocytosis (HP:0001923)1.96748682
128Abnormality of reticulocytes (HP:0004312)1.96685644
129CNS hypomyelination (HP:0003429)1.95844206
130Spastic paraparesis (HP:0002313)1.95599590
131Abnormality of the ileum (HP:0001549)1.94441030
132Myocardial infarction (HP:0001658)1.93830209
133Brushfield spots (HP:0001088)1.93153449
134Truncus arteriosus (HP:0001660)1.92555872
135Secondary amenorrhea (HP:0000869)1.91038182
136Increased purine levels (HP:0004368)1.90145689
137Hyperuricemia (HP:0002149)1.90145689
138Redundant skin (HP:0001582)1.89223138
139Abnormality of vitamin metabolism (HP:0100508)1.88575433
140Neonatal onset (HP:0003623)1.87541977
141Skin nodule (HP:0200036)1.87464479
142Symptomatic seizures (HP:0011145)1.85460624
143Degeneration of anterior horn cells (HP:0002398)1.85130502
144Abnormality of the anterior horn cell (HP:0006802)1.85130502
145Nausea (HP:0002018)1.84425858
146Cardiovascular calcification (HP:0011915)1.81948552
147Methylmalonic aciduria (HP:0012120)1.81749709
148Abnormal enzyme/coenzyme activity (HP:0012379)1.81500024
149Horseshoe kidney (HP:0000085)1.79584419
150Rhabdomyolysis (HP:0003201)1.78960556
151CNS demyelination (HP:0007305)1.76497412
152Abnormality of the gallbladder (HP:0005264)1.75867387
153Acute hepatic failure (HP:0006554)1.75327875
154Rickets (HP:0002748)1.75158236
155Abnormality of transition element cation homeostasis (HP:0011030)1.74330122
156Optic disc pallor (HP:0000543)1.73508764
157Esophageal varix (HP:0002040)1.72997603
158Small intestinal stenosis (HP:0012848)1.72832606
159Duodenal stenosis (HP:0100867)1.72832606
160Hyperglycemia (HP:0003074)1.71323170
161Reticulocytopenia (HP:0001896)1.70634764
162Rough bone trabeculation (HP:0100670)1.69648837
163Abnormal hemoglobin (HP:0011902)1.68744487
164Carpal bone hypoplasia (HP:0001498)1.67831233
165Abnormal gallbladder morphology (HP:0012437)1.66255398
166Abnormality of alkaline phosphatase activity (HP:0004379)1.66136239
167Progressive muscle weakness (HP:0003323)1.64929232
168Lactic acidosis (HP:0003128)1.62383326
169Reduced antithrombin III activity (HP:0001976)1.61708804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.06538736
2VRK23.92224782
3ERN13.89106376
4BUB13.27350915
5ZAK2.84741452
6EIF2AK12.31340750
7TLK12.31261801
8NME22.30021688
9WEE12.28563589
10EIF2AK32.27823922
11ARAF2.13105001
12PKN22.06520302
13FLT31.91845788
14PASK1.85293474
15SIK11.78649796
16PIM21.78335214
17FGFR41.78126294
18TRIB31.76719136
19STK161.75184004
20MAP2K21.71044628
21RPS6KB21.60440598
22EPHA21.54661044
23TESK21.53384415
24TTK1.47067482
25CCNB11.46699698
26NEK11.45577311
27CSNK1G31.39338646
28MAPKAPK31.35839426
29MST1R1.32050082
30SMG11.32008831
31PBK1.28820534
32INSRR1.28620266
33MET1.26910787
34NEK21.24076135
35MAP3K111.23806148
36MAPK111.22129194
37MAP3K31.21417633
38MAPKAPK51.16706360
39CSNK1A1L1.15594711
40ERBB41.15361206
41STK38L1.13665764
42LIMK11.12490690
43AURKA1.12024331
44CSNK1G11.11924037
45CDC71.11597583
46NUAK11.11200847
47MAP3K81.10691041
48KDR1.07546950
49MAPK151.06243205
50PLK11.03801743
51RAF11.02621077
52MAP3K100.99790409
53CDK80.98884678
54SCYL20.97681138
55BRSK20.95548848
56CSNK1G20.95280306
57AURKB0.95152035
58CDK70.94008773
59ACVR1B0.93697563
60TSSK60.89032522
61VRK10.88553472
62PRKD30.88473334
63PIK3CG0.87987855
64IRAK30.85631164
65PTK60.83828087
66ABL20.83070019
67CDK40.81491254
68BRAF0.80843114
69DAPK10.79857211
70LATS10.76073613
71PRKCI0.75323308
72SRPK10.74147470
73LRRK20.73302222
74MAP2K60.72376403
75TAF10.70032972
76DYRK1B0.68279261
77BRSK10.67163625
78PAK40.67005720
79EEF2K0.66243610
80PLK40.65998014
81TGFBR10.65678317
82DYRK30.64685575
83ATM0.63794251
84RPS6KA40.63764394
85EIF2AK20.63461888
86MST40.63164830
87ILK0.62089210
88STK100.60908677
89DAPK30.60855767
90RPS6KA50.58610296
91MTOR0.57573975
92NME10.57434315
93LATS20.56566733
94CSNK2A20.55989283
95CSNK2A10.54452639
96TAOK20.54327995
97MAP2K30.54022377
98PDK40.53945421
99PDK30.53945421
100TAOK30.51690579
101CDK10.51330049
102CDK60.50951987
103ATR0.50816676
104PLK20.50084880
105DYRK20.46298200
106CLK10.46151091
107GRK60.45201851
108ZAP700.44839872
109CDK11A0.44419255
110CHEK20.44015581
111TYK20.43732688
112NEK90.42731858
113CAMK2G0.42364089
114TESK10.42144244
115CDK140.40704051
116MYLK0.40385298
117CSNK1E0.39793897
118STK40.39723462
119PAK20.39472233
120CDK150.38674504
121CDK180.36774461
122PAK60.35445122
123AKT20.35095441
124PDK20.34218833
125PTK20.33848437
126CHEK10.32900131
127MELK0.32779321
128ERBB20.31181692
129IRAK20.30809202
130CDK20.30318659
131FRK0.30292225
132MAP2K10.30231249
133MAP4K20.29305099
134PHKG10.28798673
135PHKG20.28798673
136PRKDC0.28589353
137PAK10.28454375
138BMPR1B0.26509375
139EPHA40.25665806
140PLK30.25526933
141LMTK20.24989926
142MAP3K120.24965642
143CDK190.24946859
144CAMK2D0.24365385
145MAP2K70.24321124

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.23003488
2* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.85168891
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83982053
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59280148
5Nitrogen metabolism_Homo sapiens_hsa009102.49806062
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48754283
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47583450
8Folate biosynthesis_Homo sapiens_hsa007902.36331468
9Arginine biosynthesis_Homo sapiens_hsa002202.28390449
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.20456912
11Fat digestion and absorption_Homo sapiens_hsa049752.19292706
12Tryptophan metabolism_Homo sapiens_hsa003802.15193493
13One carbon pool by folate_Homo sapiens_hsa006702.07936840
14Fatty acid degradation_Homo sapiens_hsa000712.03303394
15Selenocompound metabolism_Homo sapiens_hsa004501.99125863
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96971940
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87514511
18Propanoate metabolism_Homo sapiens_hsa006401.87059922
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.86540710
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81556150
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.79654668
22Biosynthesis of amino acids_Homo sapiens_hsa012301.78657832
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74498549
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73001659
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.69373685
26Butanoate metabolism_Homo sapiens_hsa006501.67558376
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62692448
28Peroxisome_Homo sapiens_hsa041461.62653345
29Complement and coagulation cascades_Homo sapiens_hsa046101.62094089
30Chemical carcinogenesis_Homo sapiens_hsa052041.60506035
31Histidine metabolism_Homo sapiens_hsa003401.56919938
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56154439
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56114085
34Fanconi anemia pathway_Homo sapiens_hsa034601.55102550
35beta-Alanine metabolism_Homo sapiens_hsa004101.51835548
36Huntingtons disease_Homo sapiens_hsa050161.47443800
37Steroid biosynthesis_Homo sapiens_hsa001001.45059544
38Non-homologous end-joining_Homo sapiens_hsa034501.40938892
39Pyruvate metabolism_Homo sapiens_hsa006201.40265487
40Carbon metabolism_Homo sapiens_hsa012001.37751889
41Ribosome_Homo sapiens_hsa030101.36366312
42Arginine and proline metabolism_Homo sapiens_hsa003301.35399628
43Fatty acid metabolism_Homo sapiens_hsa012121.32498230
44Phenylalanine metabolism_Homo sapiens_hsa003601.32481537
45Sulfur relay system_Homo sapiens_hsa041221.30573822
46Retinol metabolism_Homo sapiens_hsa008301.29548141
47Sulfur metabolism_Homo sapiens_hsa009201.26991288
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25312046
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.21688116
50Glutathione metabolism_Homo sapiens_hsa004801.17098457
51Fatty acid elongation_Homo sapiens_hsa000621.16642630
52Cell cycle_Homo sapiens_hsa041101.14945146
53Tyrosine metabolism_Homo sapiens_hsa003501.14175609
54Vitamin digestion and absorption_Homo sapiens_hsa049771.13864189
55Alzheimers disease_Homo sapiens_hsa050101.12378715
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10560903
57PPAR signaling pathway_Homo sapiens_hsa033201.06277538
58Protein export_Homo sapiens_hsa030601.03652749
59Proteasome_Homo sapiens_hsa030501.01460760
60Starch and sucrose metabolism_Homo sapiens_hsa005001.00756873
61Caffeine metabolism_Homo sapiens_hsa002321.00194761
62Pancreatic secretion_Homo sapiens_hsa049720.96910923
63Glycerolipid metabolism_Homo sapiens_hsa005610.94735655
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94252244
65DNA replication_Homo sapiens_hsa030300.94235425
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92423435
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91534327
68Vitamin B6 metabolism_Homo sapiens_hsa007500.90430668
69Pentose phosphate pathway_Homo sapiens_hsa000300.87566134
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84285046
71Mismatch repair_Homo sapiens_hsa034300.82359614
72Protein digestion and absorption_Homo sapiens_hsa049740.81303732
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78353539
74Bile secretion_Homo sapiens_hsa049760.78271178
75Staphylococcus aureus infection_Homo sapiens_hsa051500.76619099
76Pyrimidine metabolism_Homo sapiens_hsa002400.76134715
77Basal transcription factors_Homo sapiens_hsa030220.74869030
78RNA degradation_Homo sapiens_hsa030180.72630785
79Metabolic pathways_Homo sapiens_hsa011000.68901091
80RNA polymerase_Homo sapiens_hsa030200.66426586
81Fructose and mannose metabolism_Homo sapiens_hsa000510.66006035
82Linoleic acid metabolism_Homo sapiens_hsa005910.65953257
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65756505
84N-Glycan biosynthesis_Homo sapiens_hsa005100.65446196
85Cardiac muscle contraction_Homo sapiens_hsa042600.65208051
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64544260
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61666800
88Lysine degradation_Homo sapiens_hsa003100.57389047
89mRNA surveillance pathway_Homo sapiens_hsa030150.56538878
90ABC transporters_Homo sapiens_hsa020100.56016703
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55847942
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52407673
93Base excision repair_Homo sapiens_hsa034100.51378750
94Oocyte meiosis_Homo sapiens_hsa041140.49049220
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47365689
96Galactose metabolism_Homo sapiens_hsa000520.47310797
97RNA transport_Homo sapiens_hsa030130.45667201
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44001605
99Nucleotide excision repair_Homo sapiens_hsa034200.40175355
100p53 signaling pathway_Homo sapiens_hsa041150.38084927
101Spliceosome_Homo sapiens_hsa030400.36247286
102Homologous recombination_Homo sapiens_hsa034400.33161545
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29066114
104Arachidonic acid metabolism_Homo sapiens_hsa005900.27005957
105Systemic lupus erythematosus_Homo sapiens_hsa053220.26599671
106Vibrio cholerae infection_Homo sapiens_hsa051100.24744475
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23469540
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23371220
109Oxidative phosphorylation_Homo sapiens_hsa001900.22376172
110Fatty acid biosynthesis_Homo sapiens_hsa000610.21429011
111Renin-angiotensin system_Homo sapiens_hsa046140.21015448
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20094783
113Parkinsons disease_Homo sapiens_hsa050120.19820423
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18659467
115Purine metabolism_Homo sapiens_hsa002300.13172304
116Other glycan degradation_Homo sapiens_hsa005110.08592705
117Prion diseases_Homo sapiens_hsa050200.05873084
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05393889

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