GCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.96642617
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91965622
3vocalization behavior (GO:0071625)4.75067886
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36448592
5synaptic vesicle exocytosis (GO:0016079)4.35995053
6neuron cell-cell adhesion (GO:0007158)4.30874939
7glutamate secretion (GO:0014047)4.27901681
8cilium or flagellum-dependent cell motility (GO:0001539)4.27727961
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.23812067
10monoubiquitinated protein deubiquitination (GO:0035520)4.20517941
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20130841
12regulation of synaptic vesicle exocytosis (GO:2000300)4.13868326
13protein K11-linked deubiquitination (GO:0035871)4.12848866
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12195092
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.04355212
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.03747348
17glutamate receptor signaling pathway (GO:0007215)3.97272609
18interkinetic nuclear migration (GO:0022027)3.96536674
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95793324
20protein localization to synapse (GO:0035418)3.94447864
21presynaptic membrane assembly (GO:0097105)3.92901830
22regulation of glutamate receptor signaling pathway (GO:1900449)3.89266629
23regulation of synaptic vesicle transport (GO:1902803)3.87252545
24negative regulation of translation, ncRNA-mediated (GO:0040033)3.84499511
25regulation of translation, ncRNA-mediated (GO:0045974)3.84499511
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.84499511
27synaptic vesicle maturation (GO:0016188)3.82027978
28phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.80456926
29neuron-neuron synaptic transmission (GO:0007270)3.75895082
30histone H3-K4 trimethylation (GO:0080182)3.71386845
31centriole replication (GO:0007099)3.69615538
32neuronal action potential propagation (GO:0019227)3.67956153
33synaptic transmission, glutamatergic (GO:0035249)3.67146564
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65770945
35retinal cone cell development (GO:0046549)3.63630717
36neurotransmitter secretion (GO:0007269)3.58125786
37epithelial cilium movement (GO:0003351)3.53025970
38cilium movement (GO:0003341)3.51291127
39detection of light stimulus involved in visual perception (GO:0050908)3.50535156
40detection of light stimulus involved in sensory perception (GO:0050962)3.50535156
41rRNA catabolic process (GO:0016075)3.50529211
42neuron recognition (GO:0008038)3.49959568
43long-term synaptic potentiation (GO:0060291)3.47407863
44presynaptic membrane organization (GO:0097090)3.47158187
45startle response (GO:0001964)3.45684420
46locomotory exploration behavior (GO:0035641)3.44920845
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43273651
48neurotransmitter-gated ion channel clustering (GO:0072578)3.43033846
49regulation of neuronal synaptic plasticity (GO:0048168)3.43022967
50* protein localization to Golgi apparatus (GO:0034067)3.42635295
51synaptic vesicle endocytosis (GO:0048488)3.42368396
52neural tube formation (GO:0001841)3.41792558
53regulation of establishment of cell polarity (GO:2000114)3.34873591
54protein K63-linked deubiquitination (GO:0070536)3.32897821
55response to histamine (GO:0034776)3.32635053
56negative regulation of dendrite morphogenesis (GO:0050774)3.32394151
57gamma-aminobutyric acid transport (GO:0015812)3.31287292
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31166150
59* protein targeting to Golgi (GO:0000042)3.31045890
60regulation of postsynaptic membrane potential (GO:0060078)3.30974207
61detection of calcium ion (GO:0005513)3.26330425
62cerebellar Purkinje cell differentiation (GO:0021702)3.25119843
63long-term memory (GO:0007616)3.21060702
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18477406
65regulation of dendritic spine morphogenesis (GO:0061001)3.15840151
66axonal fasciculation (GO:0007413)3.14673775
67axoneme assembly (GO:0035082)3.14608126
68positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.12380925
69regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.12380925
70histone mRNA catabolic process (GO:0071044)3.09837845
71neurotransmitter transport (GO:0006836)3.09570677
72negative regulation of neurotransmitter transport (GO:0051589)3.08271276
73transmission of nerve impulse (GO:0019226)3.08147813
74regulation of cilium movement (GO:0003352)3.07650839
75proline transport (GO:0015824)3.06284495
76postsynaptic membrane organization (GO:0001941)3.06179872
77prenylation (GO:0097354)3.06019536
78protein prenylation (GO:0018342)3.06019536
79regulation of synaptic plasticity (GO:0048167)3.05341290
80dendritic spine morphogenesis (GO:0060997)3.04055030
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03921826
82exploration behavior (GO:0035640)3.03394446
83regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.03136519
84positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.03136519
85regulation of establishment or maintenance of cell polarity (GO:0032878)3.02866946
86innervation (GO:0060384)3.00938314
87positive regulation of mRNA catabolic process (GO:0061014)3.00721626
88protein K48-linked deubiquitination (GO:0071108)2.98226584
89* retrograde transport, vesicle recycling within Golgi (GO:0000301)2.97525819
90female mating behavior (GO:0060180)2.96724451
91regulation of female receptivity (GO:0045924)2.96404912
92fucose catabolic process (GO:0019317)2.95616043
93L-fucose metabolic process (GO:0042354)2.95616043
94L-fucose catabolic process (GO:0042355)2.95616043
95Golgi to endosome transport (GO:0006895)2.95465932
96negative regulation of dendrite development (GO:2000171)2.95352781
97peptidyl-lysine trimethylation (GO:0018023)2.94787202
98long term synaptic depression (GO:0060292)2.94581655
99vesicle transport along microtubule (GO:0047496)2.94513485
100positive regulation of neurotransmitter secretion (GO:0001956)2.91498195
101regulation of vesicle fusion (GO:0031338)2.91191563
102kidney morphogenesis (GO:0060993)2.91131036
103serotonin metabolic process (GO:0042428)2.90899686
104cochlea development (GO:0090102)2.89238761
105histone H3-K9 methylation (GO:0051567)2.88656507
106positive regulation of membrane potential (GO:0045838)2.88654027
107regulation of neurotransmitter secretion (GO:0046928)2.88277435
108synapse assembly (GO:0007416)2.87014608
109positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.84869795
110regulation of glutamate secretion (GO:0014048)2.84781716
111* establishment of protein localization to Golgi (GO:0072600)2.84760025
112membrane depolarization (GO:0051899)2.83664154
113axonemal dynein complex assembly (GO:0070286)2.83650200
114centriole assembly (GO:0098534)2.83627274
115regulation of neurotransmitter levels (GO:0001505)2.83211109
116striatum development (GO:0021756)2.82399759
117mechanosensory behavior (GO:0007638)2.81547905
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.81453581
119righting reflex (GO:0060013)2.79109100
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77144459
121cyclic nucleotide catabolic process (GO:0009214)2.74536976
122behavioral response to cocaine (GO:0048148)2.74516603
123protein localization to cilium (GO:0061512)2.74084746
124cAMP catabolic process (GO:0006198)2.72373688
125cellular potassium ion homeostasis (GO:0030007)2.72324499
126regulation of meiosis I (GO:0060631)2.71116568
127behavioral fear response (GO:0001662)2.70789366
128behavioral defense response (GO:0002209)2.70789366
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.70725427
130cilium morphogenesis (GO:0060271)2.70375655
131membrane hyperpolarization (GO:0060081)2.69585645
132cellular response to ethanol (GO:0071361)2.69011655
133RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66616455
134positive regulation of neurotransmitter transport (GO:0051590)2.66452586
135regulation of neurotransmitter transport (GO:0051588)2.66311408
136water-soluble vitamin biosynthetic process (GO:0042364)2.63569391
137learning (GO:0007612)2.63547001
138regulation of exocytosis (GO:0017157)2.63458018
139membrane depolarization during action potential (GO:0086010)2.63027292
140fear response (GO:0042596)2.62981776
141establishment of synaptic vesicle localization (GO:0097480)2.62854913
142synaptic vesicle transport (GO:0048489)2.62854913
143regulation of DNA endoreduplication (GO:0032875)2.61987588
144positive regulation of exocytosis (GO:0045921)2.61939615
145dendritic spine organization (GO:0097061)2.60847755
146regulation of synapse structural plasticity (GO:0051823)2.60265936
147regulation of dendritic spine development (GO:0060998)2.58765733
148cilium organization (GO:0044782)2.58687101
149sulfation (GO:0051923)2.58503612
150establishment of vesicle localization (GO:0051650)2.57194245
151interleukin-6-mediated signaling pathway (GO:0070102)2.57012311
152cerebellar granule cell differentiation (GO:0021707)2.56962403
153lipid translocation (GO:0034204)2.56646450
154phospholipid translocation (GO:0045332)2.56646450
155synaptic transmission (GO:0007268)2.56442802
156serotonin receptor signaling pathway (GO:0007210)2.56296411
157regulation of protein glycosylation (GO:0060049)2.53458729
158negative regulation of neurotransmitter secretion (GO:0046929)2.51884208
159transepithelial transport (GO:0070633)2.51430655
160ncRNA catabolic process (GO:0034661)2.51249102
161positive regulation of glycolytic process (GO:0045821)2.50865812
162regulation of gamma-delta T cell differentiation (GO:0045586)2.50159935
163intestinal epithelial cell development (GO:0060576)2.48606826
164peptidyl-lysine methylation (GO:0018022)2.46837223
165photoreceptor cell maintenance (GO:0045494)2.46555197
166regulation of mRNA catabolic process (GO:0061013)2.46462110
167cilium assembly (GO:0042384)2.43706849
168negative T cell selection (GO:0043383)2.43506638
169regulation of energy homeostasis (GO:2000505)2.43024051
170cellular response to interleukin-15 (GO:0071350)2.40602751
171early endosome to late endosome transport (GO:0045022)2.35268341
172detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34429827
173positive regulation of mRNA metabolic process (GO:1903313)2.33149466
174nucleus localization (GO:0051647)2.32500696
175retina layer formation (GO:0010842)2.31998534
176thyroid hormone metabolic process (GO:0042403)2.31763980
177single strand break repair (GO:0000012)2.30772210
178peptidyl-threonine dephosphorylation (GO:0035970)2.30471722
179interferon-gamma production (GO:0032609)2.29907309
180positive regulation of protein autophosphorylation (GO:0031954)2.29284185
181negative regulation of DNA-dependent DNA replication (GO:2000104)2.28133834
182histone H3-K9 modification (GO:0061647)2.27748436
183eye photoreceptor cell development (GO:0042462)2.27545977
184photoreceptor cell development (GO:0042461)2.27238136
185positive regulation of mRNA processing (GO:0050685)2.26693269
186negative thymic T cell selection (GO:0045060)2.25831610
187tonic smooth muscle contraction (GO:0014820)2.25362365
188vascular smooth muscle contraction (GO:0014829)2.25299555
189regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.23901832
190histone-serine phosphorylation (GO:0035404)2.22847366
191signal peptide processing (GO:0006465)2.22832676
192cytoplasmic mRNA processing body assembly (GO:0033962)2.22593498
193positive regulation of granulocyte differentiation (GO:0030854)2.21617641
194artery smooth muscle contraction (GO:0014824)2.21155969
195regulation of gene silencing by miRNA (GO:0060964)2.20643733
196regulation of gene silencing by RNA (GO:0060966)2.20643733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.31882313
2EZH2_22144423_ChIP-Seq_EOC_Human3.89658394
3TAF15_26573619_Chip-Seq_HEK293_Human2.57456063
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52052471
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33619232
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29119093
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21893119
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21040207
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20173410
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18907376
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17806618
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16541543
13SMAD4_21799915_ChIP-Seq_A2780_Human2.11794399
14FUS_26573619_Chip-Seq_HEK293_Human2.08885096
15P300_19829295_ChIP-Seq_ESCs_Human2.06862926
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06109737
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02188491
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.00749714
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.95910720
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94632903
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90968636
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88051656
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85364372
24IGF1R_20145208_ChIP-Seq_DFB_Human1.84662912
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79413976
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78292383
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78137231
28REST_21632747_ChIP-Seq_MESCs_Mouse1.75315432
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73977853
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70880246
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70642657
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.69970719
33STAT3_23295773_ChIP-Seq_U87_Human1.69563024
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66714644
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65769636
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64952213
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64926351
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64895674
39AR_25329375_ChIP-Seq_VCAP_Human1.63104049
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.61925551
41AR_21572438_ChIP-Seq_LNCaP_Human1.61601443
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61533298
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60955676
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60000551
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59178999
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57221438
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57221438
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56663818
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.55510511
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.55429949
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54556810
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.54122084
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52839857
54DROSHA_22980978_ChIP-Seq_HELA_Human1.52303154
55BCAT_22108803_ChIP-Seq_LS180_Human1.50943758
56* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49293661
57* TP53_16413492_ChIP-PET_HCT116_Human1.49090860
58TCF4_23295773_ChIP-Seq_U87_Human1.48460387
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.46547137
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46155642
61ER_23166858_ChIP-Seq_MCF-7_Human1.46065828
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.45387022
63EWS_26573619_Chip-Seq_HEK293_Human1.42788285
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42461825
65TP53_18474530_ChIP-ChIP_U2OS_Human1.42454766
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42408269
67ZNF274_21170338_ChIP-Seq_K562_Hela1.41986761
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.41431985
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.39233118
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37955764
71* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37897226
72AHR_22903824_ChIP-Seq_MCF-7_Human1.37585162
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37122114
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.35961052
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35092480
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34142443
77TCF4_22108803_ChIP-Seq_LS180_Human1.33691819
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.32616261
79* CDX2_22108803_ChIP-Seq_LS180_Human1.31612319
80VDR_22108803_ChIP-Seq_LS180_Human1.31417416
81P53_22387025_ChIP-Seq_ESCs_Mouse1.30481993
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28957075
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28957075
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28754863
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.28524642
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28333293
87* PRDM14_20953172_ChIP-Seq_ESCs_Human1.27463431
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27296408
89* CRX_20693478_ChIP-Seq_RETINA_Mouse1.26321682
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.24738963
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.23862826
92* FLI1_21867929_ChIP-Seq_TH2_Mouse1.23189327
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21060034
94CBP_20019798_ChIP-Seq_JUKART_Human1.21060034
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20975663
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20975663
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20390582
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19228127
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18875923
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17718765
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.17543571
102* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16065634
103RUNX_20019798_ChIP-Seq_JUKART_Human1.15053951
104KDM2B_26808549_Chip-Seq_REH_Human1.14817138
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.14487801
106JUN_21703547_ChIP-Seq_K562_Human1.14199180
107P300_18555785_Chip-Seq_ESCs_Mouse1.13012872
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11914271
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.11911439
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11619767
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11527228
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.11419984
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.10773930
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10761079
115SOX2_19829295_ChIP-Seq_ESCs_Human1.10541267
116NANOG_19829295_ChIP-Seq_ESCs_Human1.10541267
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10532065
118* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10300294
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09946874
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09831058
121* EZH2_27294783_Chip-Seq_NPCs_Mouse1.08751636
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.08522740
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.07816490
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07220022
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03560584
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03531308
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01002749
128NMYC_18555785_Chip-Seq_ESCs_Mouse1.00716896
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.99542364
130IRF8_22096565_ChIP-ChIP_GC-B_Human0.98809353
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.97733328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.91630398
2MP0004859_abnormal_synaptic_plasticity4.87964834
3MP0008057_abnormal_DNA_replication3.61877970
4MP0003635_abnormal_synaptic_transmissio3.52739329
5MP0003195_calcinosis3.40326776
6MP0009780_abnormal_chondrocyte_physiolo3.36087840
7MP0004270_analgesia3.36048975
8MP0009745_abnormal_behavioral_response3.18648207
9MP0003787_abnormal_imprinting3.14194232
10MP0002063_abnormal_learning/memory/cond2.96441089
11MP0001968_abnormal_touch/_nociception2.82557348
12MP0002572_abnormal_emotion/affect_behav2.72918775
13MP0002064_seizures2.67463557
14MP0009046_muscle_twitch2.61284495
15MP0002736_abnormal_nociception_after2.49838753
16MP0002734_abnormal_mechanical_nocicepti2.44642280
17MP0001501_abnormal_sleep_pattern2.36888617
18MP0002272_abnormal_nervous_system2.34651369
19MP0001188_hyperpigmentation2.32628357
20MP0001486_abnormal_startle_reflex2.23707381
21MP0005646_abnormal_pituitary_gland2.20547430
22MP0001440_abnormal_grooming_behavior2.09444943
23MP0010386_abnormal_urinary_bladder2.06888789
24MP0000569_abnormal_digit_pigmentation2.03886022
25MP0006276_abnormal_autonomic_nervous1.91542985
26MP0002822_catalepsy1.88272359
27MP0002067_abnormal_sensory_capabilities1.86805358
28MP0002735_abnormal_chemical_nociception1.83222487
29MP0002909_abnormal_adrenal_gland1.80702408
30MP0004924_abnormal_behavior1.78674246
31MP0005386_behavior/neurological_phenoty1.78674246
32MP0008875_abnormal_xenobiotic_pharmacok1.78209751
33MP0002166_altered_tumor_susceptibility1.70727844
34MP0002557_abnormal_social/conspecific_i1.70487560
35MP0000778_abnormal_nervous_system1.67854940
36MP0001529_abnormal_vocalization1.63807526
37MP0010234_abnormal_vibrissa_follicle1.58540928
38MP0001970_abnormal_pain_threshold1.58466917
39MP0002876_abnormal_thyroid_physiology1.54883661
40MP0003183_abnormal_peptide_metabolism1.53945606
41MP0002733_abnormal_thermal_nociception1.50857115
42MP0005379_endocrine/exocrine_gland_phen1.49762710
43MP0005645_abnormal_hypothalamus_physiol1.48309398
44MP0005409_darkened_coat_color1.46361996
45MP0003122_maternal_imprinting1.43823938
46MP0005085_abnormal_gallbladder_physiolo1.43167575
47MP0005423_abnormal_somatic_nervous1.41494471
48MP0003866_abnormal_defecation1.40416180
49MP0001905_abnormal_dopamine_level1.40017519
50MP0002184_abnormal_innervation1.38286055
51MP0003763_abnormal_thymus_physiology1.37696499
52MP0003633_abnormal_nervous_system1.35409126
53MP0000013_abnormal_adipose_tissue1.34408701
54MP0001984_abnormal_olfaction1.33813183
55MP0000427_abnormal_hair_cycle1.33488886
56MP0002837_dystrophic_cardiac_calcinosis1.32940726
57MP0005171_absent_coat_pigmentation1.31511296
58MP0004885_abnormal_endolymph1.27466869
59MP0008569_lethality_at_weaning1.25128841
60MP0001666_abnormal_nutrient_absorption1.24822790
61MP0009697_abnormal_copulation1.23482880
62MP0005551_abnormal_eye_electrophysiolog1.22010562
63MP0006072_abnormal_retinal_apoptosis1.21920309
64MP0001177_atelectasis1.19547092
65MP0004215_abnormal_myocardial_fiber1.19093671
66MP0004811_abnormal_neuron_physiology1.17950065
67MP0003879_abnormal_hair_cell1.16036623
68MP0001502_abnormal_circadian_rhythm1.15557162
69MP0002168_other_aberrant_phenotype1.13903763
70MP0003631_nervous_system_phenotype1.13838983
71MP0002006_tumorigenesis1.12041866
72MP0000955_abnormal_spinal_cord1.11682974
73MP0005389_reproductive_system_phenotype1.11630589
74MP0005174_abnormal_tail_pigmentation1.11399166
75MP0002102_abnormal_ear_morphology1.11237950
76MP0005253_abnormal_eye_physiology1.09827891
77MP0010678_abnormal_skin_adnexa1.09180474
78MP0002160_abnormal_reproductive_system1.08803228
79MP0002066_abnormal_motor_capabilities/c1.08736441
80MP0000383_abnormal_hair_follicle1.08672026
81MP0008877_abnormal_DNA_methylation1.08390714
82MP0003329_amyloid_beta_deposits1.06575898
83MP0004134_abnormal_chest_morphology1.05406991
84MP0002882_abnormal_neuron_morphology1.05029995
85MP0004484_altered_response_of1.04579116
86MP0004043_abnormal_pH_regulation1.03953525
87MP0004147_increased_porphyrin_level1.03065062
88MP0001664_abnormal_digestion1.02124249
89MP0001919_abnormal_reproductive_system1.02038729
90MP0005075_abnormal_melanosome_morpholog1.00943548
91MP0010352_gastrointestinal_tract_polyps0.99825985
92MP0005395_other_phenotype0.97684856
93MP0003121_genomic_imprinting0.96041550
94MP0008872_abnormal_physiological_respon0.95161380
95MP0002229_neurodegeneration0.94792616
96MP0002396_abnormal_hematopoietic_system0.94230549
97MP0005535_abnormal_body_temperature0.93768990
98MP0005084_abnormal_gallbladder_morpholo0.93404071
99MP0005671_abnormal_response_to0.93214754
100MP0003718_maternal_effect0.91713902
101MP0002138_abnormal_hepatobiliary_system0.90628418
102MP0001963_abnormal_hearing_physiology0.85359016
103MP0003724_increased_susceptibility_to0.85295259
104MP0005360_urolithiasis0.85103342
105MP0002152_abnormal_brain_morphology0.83902080
106MP0001929_abnormal_gametogenesis0.81946415
107MP0003690_abnormal_glial_cell0.81327747
108MP0004742_abnormal_vestibular_system0.80853354
109MP0005636_abnormal_mineral_homeostasis0.80509924
110MP0000631_abnormal_neuroendocrine_gland0.80050034
111MP0003119_abnormal_digestive_system0.79305670
112MP0002928_abnormal_bile_duct0.78893687
113MP0002069_abnormal_eating/drinking_beha0.77835762
114MP0005167_abnormal_blood-brain_barrier0.77509455
115MP0003632_abnormal_nervous_system0.77069772
116MP0001800_abnormal_humoral_immune0.74777585
117MP0001485_abnormal_pinna_reflex0.74664413
118MP0003890_abnormal_embryonic-extraembry0.74160176
119MP0010329_abnormal_lipoprotein_level0.72686533
120MP0003252_abnormal_bile_duct0.72212855
121MP0002638_abnormal_pupillary_reflex0.71429627
122MP0003283_abnormal_digestive_organ0.71345004
123MP0000653_abnormal_sex_gland0.71117070
124MP0004145_abnormal_muscle_electrophysio0.70486597
125MP0003698_abnormal_male_reproductive0.70233343
126MP0004264_abnormal_extraembryonic_tissu0.69437852
127MP0002127_abnormal_cardiovascular_syste0.67579781
128MP0003045_fibrosis0.67560208
129MP0001765_abnormal_ion_homeostasis0.66959812
130MP0005410_abnormal_fertilization0.66874976
131MP0000703_abnormal_thymus_morphology0.66373616
132MP0003868_abnormal_feces_composition0.66256921
133MP0005187_abnormal_penis_morphology0.66254649
134MP0002009_preneoplasia0.66226370
135MP0006292_abnormal_olfactory_placode0.65512037
136MP0005647_abnormal_sex_gland0.65459335
137MP0008058_abnormal_DNA_repair0.65330924
138MP0005220_abnormal_exocrine_pancreas0.65011825
139MP0003567_abnormal_fetal_cardiomyocyte0.64808748
140MP0000470_abnormal_stomach_morphology0.64309205
141MP0004142_abnormal_muscle_tone0.63574669
142MP0000538_abnormal_urinary_bladder0.63549283
143MP0002693_abnormal_pancreas_physiology0.62744422
144MP0000015_abnormal_ear_pigmentation0.62141601
145MP0005310_abnormal_salivary_gland0.61998867
146MP0004085_abnormal_heartbeat0.61990505
147MP0001986_abnormal_taste_sensitivity0.61331186

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.80779730
2Hyperventilation (HP:0002883)4.98657913
3Atonic seizures (HP:0010819)4.89303016
4Febrile seizures (HP:0002373)4.50975788
5Epileptic encephalopathy (HP:0200134)4.49891854
6Focal seizures (HP:0007359)4.45063587
7Absence seizures (HP:0002121)4.08315157
8Progressive cerebellar ataxia (HP:0002073)3.95921803
9Fair hair (HP:0002286)3.86330545
10Abnormality of the renal cortex (HP:0011035)3.71488253
11Visual hallucinations (HP:0002367)3.69175682
12Generalized hypopigmentation of hair (HP:0011358)3.63507289
13Myokymia (HP:0002411)3.61030853
14Pancreatic cysts (HP:0001737)3.59703902
15Renal cortical cysts (HP:0000803)3.52441613
16Dialeptic seizures (HP:0011146)3.50558101
17Abnormal hair whorl (HP:0010721)3.44623805
18Excessive salivation (HP:0003781)3.43548149
19Drooling (HP:0002307)3.43548149
20Pancreatic fibrosis (HP:0100732)3.40680050
21Broad-based gait (HP:0002136)3.36998767
22Generalized tonic-clonic seizures (HP:0002069)3.35705791
23Gaze-evoked nystagmus (HP:0000640)3.34249968
24Protruding tongue (HP:0010808)3.22902126
25Stomach cancer (HP:0012126)3.15848678
26True hermaphroditism (HP:0010459)3.10514954
27Blue irides (HP:0000635)3.01823828
28Abnormality of the renal medulla (HP:0100957)2.91812824
29Epileptiform EEG discharges (HP:0011182)2.91181536
30Impaired vibration sensation in the lower limbs (HP:0002166)2.90599869
31Abnormality of midbrain morphology (HP:0002418)2.88472131
32Molar tooth sign on MRI (HP:0002419)2.88472131
33Medial flaring of the eyebrow (HP:0010747)2.86907969
34Nephronophthisis (HP:0000090)2.83085651
35Truncal ataxia (HP:0002078)2.81396999
36Papillary thyroid carcinoma (HP:0002895)2.79219867
37T lymphocytopenia (HP:0005403)2.78678617
38Scanning speech (HP:0002168)2.76879648
39Gait imbalance (HP:0002141)2.74583123
40Urinary bladder sphincter dysfunction (HP:0002839)2.74041520
41Genetic anticipation (HP:0003743)2.72455684
42Rhinitis (HP:0012384)2.67202791
43EEG with generalized epileptiform discharges (HP:0011198)2.66358402
44Abnormality of T cell number (HP:0011839)2.65541407
45Dysmetria (HP:0001310)2.60033225
46Abnormality of salivation (HP:0100755)2.57569999
47Insidious onset (HP:0003587)2.56493112
48Termporal pattern (HP:0011008)2.56493112
49Anxiety (HP:0000739)2.54218483
50Absent speech (HP:0001344)2.52344996
51Bronchiectasis (HP:0002110)2.52198410
52Congenital primary aphakia (HP:0007707)2.51127300
53Impaired smooth pursuit (HP:0007772)2.49815903
54Thyroiditis (HP:0100646)2.49589021
55Abnormal respiratory epithelium morphology (HP:0012253)2.49160444
56Abnormal respiratory motile cilium morphology (HP:0005938)2.49160444
57Action tremor (HP:0002345)2.48136567
58Dysdiadochokinesis (HP:0002075)2.45050532
59Progressive inability to walk (HP:0002505)2.44711786
60Inability to walk (HP:0002540)2.42519149
61Amblyopia (HP:0000646)2.42006411
62Abnormal ciliary motility (HP:0012262)2.41193072
63Hypsarrhythmia (HP:0002521)2.40154822
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38183148
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.38183148
66Congenital stationary night blindness (HP:0007642)2.36038035
67Volvulus (HP:0002580)2.33822174
68Poor coordination (HP:0002370)2.33428842
69Nephrogenic diabetes insipidus (HP:0009806)2.30943531
70Poor eye contact (HP:0000817)2.28744583
71Chronic bronchitis (HP:0004469)2.26813591
72Cystic liver disease (HP:0006706)2.26561128
73Tubulointerstitial nephritis (HP:0001970)2.26080350
74Abnormality of the corticospinal tract (HP:0002492)2.24776142
75Clumsiness (HP:0002312)2.20878006
76Acanthocytosis (HP:0001927)2.19807825
77Widely spaced teeth (HP:0000687)2.19480940
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.17601669
79Absent/shortened dynein arms (HP:0200106)2.17601669
80Cerebral inclusion bodies (HP:0100314)2.17529556
81Abnormal respiratory motile cilium physiology (HP:0012261)2.17285401
82Bronchitis (HP:0012387)2.15011414
83Exotropia (HP:0000577)2.12799532
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.11303487
85Agitation (HP:0000713)2.09508742
86Inappropriate behavior (HP:0000719)2.08389661
87Abnormality of binocular vision (HP:0011514)2.07888547
88Diplopia (HP:0000651)2.07888547
89Gonadotropin excess (HP:0000837)2.07819873
90Abnormality of the nasal septum (HP:0000419)2.07753567
91Metabolic alkalosis (HP:0200114)2.07638367
92Recurrent bronchitis (HP:0002837)2.06897418
93Attenuation of retinal blood vessels (HP:0007843)2.06784272
94Impaired vibratory sensation (HP:0002495)2.06196050
95Supranuclear gaze palsy (HP:0000605)2.06100511
96Impaired social interactions (HP:0000735)2.04314128
97Abnormal social behavior (HP:0012433)2.04314128
98Abnormality of ocular smooth pursuit (HP:0000617)2.04109211
99Pheochromocytoma (HP:0002666)2.01438952
100Postural instability (HP:0002172)2.01077553
101Tubular atrophy (HP:0000092)2.01053393
102Thyroid carcinoma (HP:0002890)1.99221942
103Genital tract atresia (HP:0001827)1.98839215
104Abnormal biliary tract morphology (HP:0012440)1.97269297
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95938723
106Male pseudohermaphroditism (HP:0000037)1.95574324
107Neoplasm of the tracheobronchial system (HP:0100552)1.94873217
108Conjugated hyperbilirubinemia (HP:0002908)1.94411137
109IgG deficiency (HP:0004315)1.94080119
110Abnormality of macular pigmentation (HP:0008002)1.92906020
111Postaxial foot polydactyly (HP:0001830)1.92309863
112Lower limb muscle weakness (HP:0007340)1.92210695
113Hyperthyroidism (HP:0000836)1.91094116
114Median cleft lip (HP:0000161)1.91051276
115Decreased circulating renin level (HP:0003351)1.90649652
116Generalized myoclonic seizures (HP:0002123)1.90473332
117Spastic gait (HP:0002064)1.88750649
118Biliary tract neoplasm (HP:0100574)1.88360010
119Decreased central vision (HP:0007663)1.87780381
120Vaginal atresia (HP:0000148)1.87582434
121Abolished electroretinogram (ERG) (HP:0000550)1.87459147
122Stereotypic behavior (HP:0000733)1.86656886
123Chronic hepatic failure (HP:0100626)1.86424289
124Papilledema (HP:0001085)1.86038123
125Gait ataxia (HP:0002066)1.84928853
126Abnormal pancreas size (HP:0012094)1.84856759
127Metaphyseal dysplasia (HP:0100255)1.84535179
128Abnormality of chromosome stability (HP:0003220)1.84312901
129Supernumerary spleens (HP:0009799)1.84121142
130Abnormality of renin-angiotensin system (HP:0000847)1.84108325
131Gastroesophageal reflux (HP:0002020)1.83861170
132Congenital hepatic fibrosis (HP:0002612)1.82888469
133Autoimmune hemolytic anemia (HP:0001890)1.82227476
134Enlarged kidneys (HP:0000105)1.81383169
135Thickened helices (HP:0000391)1.81166378
136Hypothermia (HP:0002045)1.80565179
137Polydipsia (HP:0001959)1.79410959
138Abnormal drinking behavior (HP:0030082)1.79410959
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79316938
140Neuroendocrine neoplasm (HP:0100634)1.79233925
141Azoospermia (HP:0000027)1.78458689
142Specific learning disability (HP:0001328)1.78145245
143Oligodactyly (hands) (HP:0001180)1.78114903
144Abnormality of the lower motor neuron (HP:0002366)1.75809916
145Aqueductal stenosis (HP:0002410)1.75073372
146Hyperkalemia (HP:0002153)1.74840507
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.74211974
148Neurofibrillary tangles (HP:0002185)1.73909819
149Colon cancer (HP:0003003)1.73644032
150Hemiparesis (HP:0001269)1.73302835
151Labial hypoplasia (HP:0000066)1.73180538
152Urinary urgency (HP:0000012)1.72536811
153Acute myeloid leukemia (HP:0004808)1.71908627
154Depression (HP:0000716)1.71074007
155Progressive macrocephaly (HP:0004481)1.70875161
156Furrowed tongue (HP:0000221)1.70343001
157Hypokalemic alkalosis (HP:0001949)1.67214969
158Central scotoma (HP:0000603)1.67154508
159Abnormality of the vitamin B12 metabolism (HP:0004341)1.66410445
160Prostate neoplasm (HP:0100787)1.65694814
161Neoplasm of the adrenal cortex (HP:0100641)1.65541133
162Abnormality of vitamin B metabolism (HP:0004340)1.65465211
163Methylmalonic acidemia (HP:0002912)1.65136553
164Postaxial hand polydactyly (HP:0001162)1.61981712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.93480057
2EPHA43.76295928
3CASK3.69513541
4ACVR1B3.65438184
5FRK3.11107819
6MAP3K43.06832194
7MAP2K72.91947040
8MAP3K122.84531549
9PNCK2.53005056
10RIPK42.49818126
11MAP3K92.26744422
12TXK2.13417445
13AKT32.13331525
14PLK22.11589659
15MINK11.74402739
16NUAK11.71138376
17INSRR1.70515712
18DAPK21.70240746
19MAP3K131.68528092
20NLK1.68523493
21MAP2K41.64007443
22BMPR1B1.58321824
23BMPR21.55935160
24MAP3K21.51542314
25MARK11.50216887
26MKNK21.46889155
27TEC1.46536755
28OXSR11.46426663
29SGK21.41878638
30ZAK1.37080807
31BRD41.29794074
32GRK11.29768871
33FGFR31.28914528
34BRSK21.28387908
35TLK11.22894772
36GRK51.22504597
37DAPK11.20864276
38NTRK11.10922454
39SGK2231.09963058
40SGK4941.09963058
41TNIK1.09656378
42CAMK2A1.09306816
43CDK51.08920555
44EPHA31.07691561
45GRK71.07353664
46MAP4K21.05455366
47PTK2B1.05398379
48STK38L1.03578781
49CAMK2B1.03200888
50KSR11.02148174
51STK391.01819396
52IRAK11.01645119
53FES1.01376005
54WNK31.01265361
55LMTK21.00270208
56PINK11.00130001
57CAMK1G0.98875083
58MAPK130.98127958
59TAOK30.98044845
60PRKCG0.97460395
61MST40.96047293
62BCR0.90014258
63PASK0.89092082
64SGK10.87456612
65SGK30.87015011
66JAK10.86947785
67TRPM70.86833643
68IKBKE0.86829558
69PRKD30.86474296
70FER0.86419777
71PRKCE0.83940734
72NEK60.83768681
73CAMKK10.83498453
74FGFR20.83310976
75TRIM280.79470320
76ITK0.78626594
77NTRK20.78106474
78EIF2AK30.77855005
79CAMKK20.74720405
80NME10.70375934
81MAPK150.70091692
82DYRK1A0.69758613
83MKNK10.69741411
84YES10.69610299
85STK30.66985329
86WNK10.65892119
87SIK20.64084681
88MAP2K60.62352599
89KSR20.61952075
90PRKCH0.61436626
91FGR0.61187398
92TNK20.60788749
93ERBB40.60672665
94CSNK1G20.58000089
95PAK30.56316085
96PIK3CG0.55646298
97MAP3K140.54017188
98PAK60.53971310
99PRKCQ0.53437045
100CHUK0.53059045
101DMPK0.52308355
102ERBB20.51465137
103LATS10.50650344
104MAP3K70.50521112
105CDK30.49863666
106SIK30.49513718
107STK240.49424914
108PRKAA20.49045329
109CAMK2D0.47671477
110LCK0.47315057
111STK380.47043992
112SYK0.46892250
113ARAF0.44924883
114CSNK1A1L0.44164208
115CAMK10.43274231
116CSNK1G10.42762191
117ERBB30.42649925
118PLK30.42461526
119TAF10.42381475
120STK110.42257088
121PLK40.42076751
122ATM0.41876665
123WNK40.41845863
124RET0.41651311
125CAMK2G0.41565912
126MAP3K60.41017203
127MELK0.40974354
128PIK3CA0.40821605
129RPS6KA30.40490816
130PDK10.40024373
131PRKG10.39871976
132ADRBK10.39389406
133CDK190.38065208
134RAF10.37680213
135KIT0.36848561
136MAP4K10.36636691
137PDK30.35395130
138PDK40.35395130
139PDPK10.35109681
140IGF1R0.34704601
141CSNK1D0.34216884
142CSNK1E0.34193316
143PRKCB0.33760460
144FYN0.32911502
145PRKCA0.32718804
146TIE10.32586910
147ROCK20.32347694
148ADRBK20.32063102
149MAPK100.31535025

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.89671562
2Long-term potentiation_Homo sapiens_hsa047202.79052254
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74349230
4Synaptic vesicle cycle_Homo sapiens_hsa047212.70899031
5Amphetamine addiction_Homo sapiens_hsa050312.67645707
6Circadian entrainment_Homo sapiens_hsa047132.53849790
7GABAergic synapse_Homo sapiens_hsa047272.49330838
8Morphine addiction_Homo sapiens_hsa050322.43512633
9Glutamatergic synapse_Homo sapiens_hsa047242.42621330
10Olfactory transduction_Homo sapiens_hsa047402.31461604
11Taste transduction_Homo sapiens_hsa047422.28908718
12Caffeine metabolism_Homo sapiens_hsa002322.21727364
13Insulin secretion_Homo sapiens_hsa049112.19557798
14Dopaminergic synapse_Homo sapiens_hsa047282.13923603
15Nitrogen metabolism_Homo sapiens_hsa009102.13219801
16Salivary secretion_Homo sapiens_hsa049702.12470603
17Renin secretion_Homo sapiens_hsa049242.00623352
18Collecting duct acid secretion_Homo sapiens_hsa049661.98862363
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90836664
20Serotonergic synapse_Homo sapiens_hsa047261.89973501
21Gastric acid secretion_Homo sapiens_hsa049711.81953560
22Linoleic acid metabolism_Homo sapiens_hsa005911.81130373
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74738851
24Long-term depression_Homo sapiens_hsa047301.68802796
25Cholinergic synapse_Homo sapiens_hsa047251.63944359
26Cocaine addiction_Homo sapiens_hsa050301.58837892
27ABC transporters_Homo sapiens_hsa020101.58685994
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58674153
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.50867056
30Calcium signaling pathway_Homo sapiens_hsa040201.49814180
31RNA degradation_Homo sapiens_hsa030181.48996813
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48417250
33Vibrio cholerae infection_Homo sapiens_hsa051101.47205947
34Phototransduction_Homo sapiens_hsa047441.47139623
35Basal transcription factors_Homo sapiens_hsa030221.47071037
36Propanoate metabolism_Homo sapiens_hsa006401.44304221
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39190236
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39032597
39Oxytocin signaling pathway_Homo sapiens_hsa049211.36011958
40Retinol metabolism_Homo sapiens_hsa008301.35915915
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35419126
42Homologous recombination_Homo sapiens_hsa034401.35103456
43Chemical carcinogenesis_Homo sapiens_hsa052041.34380349
44Regulation of autophagy_Homo sapiens_hsa041401.32046862
45Ether lipid metabolism_Homo sapiens_hsa005651.30893289
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30654035
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27518315
48GnRH signaling pathway_Homo sapiens_hsa049121.27108110
49Vitamin digestion and absorption_Homo sapiens_hsa049771.25691222
50Histidine metabolism_Homo sapiens_hsa003401.25489884
51Type II diabetes mellitus_Homo sapiens_hsa049301.24193147
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23554577
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19768808
54Primary immunodeficiency_Homo sapiens_hsa053401.18513249
55cAMP signaling pathway_Homo sapiens_hsa040241.17939893
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14260539
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12383495
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09218336
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08756038
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08047517
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.07312047
62Pancreatic secretion_Homo sapiens_hsa049721.06975353
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05649817
64Estrogen signaling pathway_Homo sapiens_hsa049151.05507001
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.05301524
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05259951
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.03311512
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01033845
69Fanconi anemia pathway_Homo sapiens_hsa034600.97017718
70T cell receptor signaling pathway_Homo sapiens_hsa046600.96996076
71Thyroid hormone synthesis_Homo sapiens_hsa049180.96879407
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95643341
73Protein export_Homo sapiens_hsa030600.94395630
74Graft-versus-host disease_Homo sapiens_hsa053320.93799918
75Fatty acid biosynthesis_Homo sapiens_hsa000610.92915723
76Melanogenesis_Homo sapiens_hsa049160.92768632
77Axon guidance_Homo sapiens_hsa043600.92079170
78Gap junction_Homo sapiens_hsa045400.88677763
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88580886
80Tryptophan metabolism_Homo sapiens_hsa003800.88430741
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87237490
82Glycerolipid metabolism_Homo sapiens_hsa005610.83002399
83Sulfur metabolism_Homo sapiens_hsa009200.81777031
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80367828
85ErbB signaling pathway_Homo sapiens_hsa040120.80036167
86Dorso-ventral axis formation_Homo sapiens_hsa043200.79769388
87Glioma_Homo sapiens_hsa052140.79071533
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.78211105
89Mineral absorption_Homo sapiens_hsa049780.77782655
90African trypanosomiasis_Homo sapiens_hsa051430.76371395
91Circadian rhythm_Homo sapiens_hsa047100.72996374
92Autoimmune thyroid disease_Homo sapiens_hsa053200.72683746
93Alzheimers disease_Homo sapiens_hsa050100.70574040
94Type I diabetes mellitus_Homo sapiens_hsa049400.70001598
95Inositol phosphate metabolism_Homo sapiens_hsa005620.69846741
96Glucagon signaling pathway_Homo sapiens_hsa049220.68020299
97Bile secretion_Homo sapiens_hsa049760.67261120
98Lysine degradation_Homo sapiens_hsa003100.66996772
99Rheumatoid arthritis_Homo sapiens_hsa053230.65828885
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65425411
101Choline metabolism in cancer_Homo sapiens_hsa052310.64854600
102Peroxisome_Homo sapiens_hsa041460.64718208
103Allograft rejection_Homo sapiens_hsa053300.63781134
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60670217
105Platelet activation_Homo sapiens_hsa046110.60495302
106Oocyte meiosis_Homo sapiens_hsa041140.60466345
107Arachidonic acid metabolism_Homo sapiens_hsa005900.59861001
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59476588
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58491814
110Starch and sucrose metabolism_Homo sapiens_hsa005000.57450160
111Ovarian steroidogenesis_Homo sapiens_hsa049130.57149727
112Ras signaling pathway_Homo sapiens_hsa040140.56350152
113Non-homologous end-joining_Homo sapiens_hsa034500.55513962
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55452820
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55300656
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55240374
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54524237
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54491482
119Fat digestion and absorption_Homo sapiens_hsa049750.54446005
120MAPK signaling pathway_Homo sapiens_hsa040100.54191155
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52045666
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50787982
123Oxidative phosphorylation_Homo sapiens_hsa001900.50021088
124beta-Alanine metabolism_Homo sapiens_hsa004100.49056815
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48979425
126Rap1 signaling pathway_Homo sapiens_hsa040150.43818560
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.43725355
128Wnt signaling pathway_Homo sapiens_hsa043100.37960268
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37411962
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35206303
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34232217
132Renin-angiotensin system_Homo sapiens_hsa046140.28394756
133Alcoholism_Homo sapiens_hsa050340.28345464
134Adherens junction_Homo sapiens_hsa045200.27919709
135Dilated cardiomyopathy_Homo sapiens_hsa054140.26141724
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.25977942
137Butanoate metabolism_Homo sapiens_hsa006500.25837745
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24719015
139Phagosome_Homo sapiens_hsa041450.24421355
140Cardiac muscle contraction_Homo sapiens_hsa042600.23643500
141Tight junction_Homo sapiens_hsa045300.20819517
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19696078
143Endometrial cancer_Homo sapiens_hsa052130.19162989
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18438553
145Huntingtons disease_Homo sapiens_hsa050160.18097560
146FoxO signaling pathway_Homo sapiens_hsa040680.18095545
147Prion diseases_Homo sapiens_hsa050200.17861837
148Chemokine signaling pathway_Homo sapiens_hsa040620.17531462
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15074575
150Endocytosis_Homo sapiens_hsa041440.13826686

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »