GCDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.63205440
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63205440
3L-phenylalanine metabolic process (GO:0006558)7.34091278
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.34091278
5aromatic amino acid family catabolic process (GO:0009074)6.87239792
6indole-containing compound catabolic process (GO:0042436)6.20922452
7indolalkylamine catabolic process (GO:0046218)6.20922452
8tryptophan catabolic process (GO:0006569)6.20922452
9glyoxylate metabolic process (GO:0046487)6.07627166
10kynurenine metabolic process (GO:0070189)6.00934906
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.94253653
12bile acid biosynthetic process (GO:0006699)5.84738643
13cysteine metabolic process (GO:0006534)5.72740979
14* tryptophan metabolic process (GO:0006568)5.61068978
15alpha-linolenic acid metabolic process (GO:0036109)5.47860670
16urea metabolic process (GO:0019627)5.45182664
17urea cycle (GO:0000050)5.45182664
18sulfur amino acid catabolic process (GO:0000098)5.43447397
19serine family amino acid catabolic process (GO:0009071)5.35140161
20negative regulation of fibrinolysis (GO:0051918)5.21888237
21high-density lipoprotein particle remodeling (GO:0034375)5.17832184
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.07525726
23protein carboxylation (GO:0018214)5.06007069
24peptidyl-glutamic acid carboxylation (GO:0017187)5.06007069
25nitrogen cycle metabolic process (GO:0071941)5.03746120
26regulation of fibrinolysis (GO:0051917)5.03011676
27homocysteine metabolic process (GO:0050667)5.01678337
28bile acid metabolic process (GO:0008206)4.96655138
29complement activation, alternative pathway (GO:0006957)4.94855857
30regulation of protein activation cascade (GO:2000257)4.92945392
31* aromatic amino acid family metabolic process (GO:0009072)4.88168803
32amino-acid betaine metabolic process (GO:0006577)4.84811797
33* lysine catabolic process (GO:0006554)4.77028827
34* lysine metabolic process (GO:0006553)4.77028827
35* alpha-amino acid catabolic process (GO:1901606)4.75829239
36tyrosine metabolic process (GO:0006570)4.72315531
37cellular ketone body metabolic process (GO:0046950)4.62375476
38glycine metabolic process (GO:0006544)4.61525260
39regulation of triglyceride catabolic process (GO:0010896)4.60503580
40regulation of complement activation (GO:0030449)4.59672606
41regulation of cholesterol esterification (GO:0010872)4.55343220
42serine family amino acid metabolic process (GO:0009069)4.50926937
43reverse cholesterol transport (GO:0043691)4.49763892
44macromolecular complex remodeling (GO:0034367)4.46677449
45plasma lipoprotein particle remodeling (GO:0034369)4.46677449
46protein-lipid complex remodeling (GO:0034368)4.46677449
47* cellular amino acid catabolic process (GO:0009063)4.42527069
48acylglycerol homeostasis (GO:0055090)4.41364281
49triglyceride homeostasis (GO:0070328)4.41364281
50negative regulation of sterol transport (GO:0032372)4.38405077
51negative regulation of cholesterol transport (GO:0032375)4.38405077
52coenzyme catabolic process (GO:0009109)4.35354929
53glutamate metabolic process (GO:0006536)4.33318419
54serine family amino acid biosynthetic process (GO:0009070)4.33315129
55amine catabolic process (GO:0009310)4.32349153
56cellular biogenic amine catabolic process (GO:0042402)4.32349153
57cellular modified amino acid catabolic process (GO:0042219)4.26658238
58cellular glucuronidation (GO:0052695)4.24690504
59imidazole-containing compound metabolic process (GO:0052803)4.23297455
60phospholipid efflux (GO:0033700)4.21682868
61bile acid and bile salt transport (GO:0015721)4.21488604
62drug catabolic process (GO:0042737)4.21169380
63ethanol oxidation (GO:0006069)4.18525196
64benzene-containing compound metabolic process (GO:0042537)4.16303274
65* indolalkylamine metabolic process (GO:0006586)4.13236261
66plasma lipoprotein particle clearance (GO:0034381)4.08855234
67short-chain fatty acid metabolic process (GO:0046459)4.04457688
68aldehyde catabolic process (GO:0046185)4.03898926
69ketone body metabolic process (GO:1902224)4.00008148
70dicarboxylic acid biosynthetic process (GO:0043650)3.95462052
71drug transmembrane transport (GO:0006855)3.93873413
72acetyl-CoA metabolic process (GO:0006084)3.92293886
73urate metabolic process (GO:0046415)3.92248516
74* organic acid catabolic process (GO:0016054)3.91962450
75* carboxylic acid catabolic process (GO:0046395)3.91962450
76arginine metabolic process (GO:0006525)3.91010941
77cholesterol efflux (GO:0033344)3.87725525
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.83598315
79uronic acid metabolic process (GO:0006063)3.80088683
80glucuronate metabolic process (GO:0019585)3.80088683
81low-density lipoprotein particle remodeling (GO:0034374)3.78721439
822-oxoglutarate metabolic process (GO:0006103)3.77251111
83exogenous drug catabolic process (GO:0042738)3.74913035
84plasma lipoprotein particle assembly (GO:0034377)3.72831906
85cofactor catabolic process (GO:0051187)3.72540117
86L-serine metabolic process (GO:0006563)3.72287879
87fibrinolysis (GO:0042730)3.70486599
88fatty acid beta-oxidation (GO:0006635)3.67249564
89oxidative phosphorylation (GO:0006119)3.66131331
90monocarboxylic acid catabolic process (GO:0072329)3.65587670
91regulation of bile acid biosynthetic process (GO:0070857)3.62349337
92carnitine metabolic process (GO:0009437)3.60923324
93positive regulation of triglyceride lipase activity (GO:0061365)3.60460277
94positive regulation of lipoprotein lipase activity (GO:0051006)3.60460277
95blood coagulation, intrinsic pathway (GO:0007597)3.60459506
96cholesterol homeostasis (GO:0042632)3.59984068
97branched-chain amino acid catabolic process (GO:0009083)3.59038122
98phospholipid homeostasis (GO:0055091)3.57155660
99regulation of mitochondrial translation (GO:0070129)3.56806267
100regulation of cholesterol homeostasis (GO:2000188)3.56503815
101* fatty acid oxidation (GO:0019395)3.56178902
102drug metabolic process (GO:0017144)3.55266507
103sterol homeostasis (GO:0055092)3.55058126
104flavonoid metabolic process (GO:0009812)3.54664126
105positive regulation of lipid catabolic process (GO:0050996)3.53790809
106DNA strand elongation involved in DNA replication (GO:0006271)3.48639097
107mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44517952
108branched-chain amino acid metabolic process (GO:0009081)3.37936482
109maturation of 5.8S rRNA (GO:0000460)3.34647752
110nucleobase biosynthetic process (GO:0046112)3.31727077
111DNA strand elongation (GO:0022616)3.31131895
112rRNA modification (GO:0000154)3.28952585
113negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22446553
114telomere maintenance via semi-conservative replication (GO:0032201)3.19732020
115oxaloacetate metabolic process (GO:0006107)3.16609049
116establishment of integrated proviral latency (GO:0075713)3.15875954
117DNA deamination (GO:0045006)3.12323873
118energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10631081
119ATP synthesis coupled proton transport (GO:0015986)3.10631081
120purine nucleobase biosynthetic process (GO:0009113)3.09444817
121pseudouridine synthesis (GO:0001522)3.06854558
122purine deoxyribonucleotide catabolic process (GO:0009155)3.04567833
123negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.01677349
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99977350
125ubiquinone biosynthetic process (GO:0006744)2.97736752
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.96718635
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96718635
128S-adenosylmethionine metabolic process (GO:0046500)2.88974312
129amino acid salvage (GO:0043102)2.87815525
130L-methionine salvage (GO:0071267)2.87815525
131L-methionine biosynthetic process (GO:0071265)2.87815525
132negative regulation of ligase activity (GO:0051352)2.85496228
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85496228
134deoxyribonucleotide catabolic process (GO:0009264)2.85120251
135* aspartate family amino acid catabolic process (GO:0009068)2.84328614
136epoxygenase P450 pathway (GO:0019373)2.84271938
137regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83969766
138quinone biosynthetic process (GO:1901663)2.83836956
139ribosomal small subunit assembly (GO:0000028)2.83813721
140deoxyribose phosphate catabolic process (GO:0046386)2.79749472
141regulation of cellular amino acid metabolic process (GO:0006521)2.79632554
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79526804
143negative regulation of B cell apoptotic process (GO:0002903)2.78273605
144establishment of viral latency (GO:0019043)2.74477492
145omega-hydroxylase P450 pathway (GO:0097267)2.74371396
146proteasome assembly (GO:0043248)2.73808868
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.73668617
148spliceosomal snRNP assembly (GO:0000387)2.71842068
149NADH metabolic process (GO:0006734)2.70084960
150formation of translation preinitiation complex (GO:0001731)2.70038749
151mitochondrial RNA metabolic process (GO:0000959)2.69753966
152anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68269202
153regulation of translational fidelity (GO:0006450)2.65887600
154DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65456946
155tricarboxylic acid cycle (GO:0006099)2.64788330
156pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.64539132
157signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62647811
158signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62647811
159signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62647811
160ribosome assembly (GO:0042255)2.61879694
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61659566
162intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61659566
163deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.61555142
164pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.61479575
165CENP-A containing nucleosome assembly (GO:0034080)2.61110955
166ribosome biogenesis (GO:0042254)2.60862525
167DNA strand renaturation (GO:0000733)2.59878658
168viral mRNA export from host cell nucleus (GO:0046784)2.59807781
169signal transduction involved in DNA damage checkpoint (GO:0072422)2.59206650
170signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59206650
171ubiquinone metabolic process (GO:0006743)2.58777496
172DNA unwinding involved in DNA replication (GO:0006268)2.58550782
173biotin metabolic process (GO:0006768)2.58490855
174protein targeting to mitochondrion (GO:0006626)2.58288564
175establishment of protein localization to mitochondrial membrane (GO:0090151)2.58095790
176mitochondrial respiratory chain complex assembly (GO:0033108)2.57749757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.36900370
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21138998
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86892039
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.40610537
5E2F7_22180533_ChIP-Seq_HELA_Human5.34661196
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.24265148
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21667861
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11641862
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.17138301
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90822894
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65013113
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39505166
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34073143
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.26878918
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15257372
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02521404
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85227368
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84693066
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.82988323
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.75138266
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.70591397
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57824889
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48897862
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38322654
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28380285
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27861843
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23571670
28* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18137911
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.17496581
30XRN2_22483619_ChIP-Seq_HELA_Human2.15663014
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10707379
32MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09983907
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04528063
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9436423
35VDR_23849224_ChIP-Seq_CD4+_Human1.99099133
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99082822
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96862233
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96724936
39DCP1A_22483619_ChIP-Seq_HELA_Human1.96407289
40GABP_19822575_ChIP-Seq_HepG2_Human1.95774398
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79463233
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79406366
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.79155574
44CIITA_25753668_ChIP-Seq_RAJI_Human1.75934202
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74456272
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70662108
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69257766
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68494307
49GATA1_22025678_ChIP-Seq_K562_Human1.67675119
50TTF2_22483619_ChIP-Seq_HELA_Human1.65956593
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63278899
52MYC_22102868_ChIP-Seq_BL_Human1.58473732
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57571539
54CLOCK_20551151_ChIP-Seq_293T_Human1.55455978
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.50599099
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49302204
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48753294
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.46930435
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46360370
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.43697201
61HTT_18923047_ChIP-ChIP_STHdh_Human1.43177497
62KDM5A_27292631_Chip-Seq_BREAST_Human1.41582268
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39422103
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39189988
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38459767
66VDR_21846776_ChIP-Seq_THP-1_Human1.37056660
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35744295
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35034625
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31693713
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31526604
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31507993
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28897096
73* E2F1_21310950_ChIP-Seq_MCF-7_Human1.28362332
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27014116
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22566400
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18377624
77ELK1_19687146_ChIP-ChIP_HELA_Human1.16543178
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15000049
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13866890
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12944415
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08883877
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08881878
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08313141
84MYC_18940864_ChIP-ChIP_HL60_Human1.06933677
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06032077
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05977358
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.05597274
88* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05079342
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03505012
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03251260
91BCL6_27268052_Chip-Seq_Bcells_Human1.02866056
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02033352
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00950595
94FOXP1_21924763_ChIP-Seq_HESCs_Human1.00483153
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.99938083
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98049607
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97920217
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95188661
99SPI1_23547873_ChIP-Seq_NB4_Human0.94791848
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94092405
101P68_20966046_ChIP-Seq_HELA_Human0.92314822
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90499319
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88860969
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88110928
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87910881
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87757235
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87703107
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87426264
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87289796
110GATA4_25053715_ChIP-Seq_YYC3_Human0.86824539
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86778742
112CTCF_26484167_Chip-Seq_Bcells_Mouse0.86503740
113TFEB_21752829_ChIP-Seq_HELA_Human0.86370596
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86006760
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85502352
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85126833
117PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84676052
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81823255
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81529690
120KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80963580
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78530926
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78099665
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.77941087
124IRF8_22096565_ChIP-ChIP_GC-B_Human0.76952018
125ZNF263_19887448_ChIP-Seq_K562_Human0.75240737
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69868299
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69093466
128RARB_24833708_ChIP-Seq_LIVER_Mouse0.67038109
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66179470
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65960838
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.65392094
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63911597
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63554575
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61543716
135AR_20517297_ChIP-Seq_VCAP_Human0.59843376
136* CEBPB_22108803_ChIP-Seq_LS180_Human0.59341670
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.58633904
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.56853262
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.55795695
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55163812
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.54636471
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.54544429
143* LXR_22292898_ChIP-Seq_THP-1_Human0.53425995
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53197237
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52534042
146MYC_19915707_ChIP-ChIP_AK7_Human0.52402792
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.50931791
148EGR1_19032775_ChIP-ChIP_M12_Human0.50557461
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.50531817
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.49794598
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.49794598
152CBP_21632823_ChIP-Seq_H3396_Human0.47642849
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46452480
154STAT1_17558387_ChIP-Seq_HELA_Human0.45818899
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45731264
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45553589
157* TAF2_19829295_ChIP-Seq_ESCs_Human0.45498599
158* P53_21459846_ChIP-Seq_SAOS-2_Human0.44813655
159* GATA1_19941827_ChIP-Seq_MEL_Mouse0.44122268
160* GATA6_25053715_ChIP-Seq_YYC3_Human0.43251984
161ERG_20517297_ChIP-Seq_VCAP_Human0.41873398
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41867714
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.41788075
164* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41068736
165IRF1_19129219_ChIP-ChIP_H3396_Human0.40895290
166GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40059681
167GATA1_19941826_ChIP-Seq_K562_Human0.39879109
168STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39855521
169CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38977717
170BCOR_27268052_Chip-Seq_Bcells_Human0.37915675
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37632928
172SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.37632918
173TET1_21451524_ChIP-Seq_MESCs_Mouse0.37395304
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37313258
175GATA2_19941826_ChIP-Seq_K562_Human0.36603115
176POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.36135225
177SRF_21415370_ChIP-Seq_HL-1_Mouse0.35818444
178SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.35546042
179FOXO3_23340844_ChIP-Seq_DLD1_Human0.35139465
180NCOR_22424771_ChIP-Seq_293T_Human0.34979911
181NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.34799692
182ERG_21242973_ChIP-ChIP_JURKAT_Human0.34455029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.23230781
2MP0005360_urolithiasis7.61625948
3MP0005085_abnormal_gallbladder_physiolo6.27402279
4MP0005365_abnormal_bile_salt6.08806978
5MP0008875_abnormal_xenobiotic_pharmacok5.14085245
6MP0003806_abnormal_nucleotide_metabolis4.35604423
7MP0010094_abnormal_chromosome_stability3.93783587
8MP0003252_abnormal_bile_duct3.81779717
9MP0010329_abnormal_lipoprotein_level3.43081194
10MP0003693_abnormal_embryo_hatching3.42259902
11MP0008058_abnormal_DNA_repair3.34433389
12MP0003111_abnormal_nucleus_morphology3.28147936
13MP0005332_abnormal_amino_acid3.07151881
14MP0009840_abnormal_foam_cell3.04894583
15MP0003195_calcinosis3.04022077
16MP0005083_abnormal_biliary_tract3.00870150
17MP0001666_abnormal_nutrient_absorption2.65490222
18MP0003077_abnormal_cell_cycle2.45600897
19MP0004019_abnormal_vitamin_homeostasis2.38899725
20MP0003191_abnormal_cellular_cholesterol2.23325778
21MP0002138_abnormal_hepatobiliary_system2.13715431
22MP0000609_abnormal_liver_physiology2.11947394
23MP0002118_abnormal_lipid_homeostasis2.08148246
24MP0002396_abnormal_hematopoietic_system2.02582566
25MP0004957_abnormal_blastocyst_morpholog2.01104432
26MP0005319_abnormal_enzyme/_coenzyme1.88986924
27MP0008007_abnormal_cellular_replicative1.88882394
28MP0003868_abnormal_feces_composition1.85129677
29MP0001764_abnormal_homeostasis1.77003281
30MP0003786_premature_aging1.76494429
31MP0008932_abnormal_embryonic_tissue1.71596822
32MP0005075_abnormal_melanosome_morpholog1.67078389
33MP0005584_abnormal_enzyme/coenzyme_acti1.64051251
34MP0001835_abnormal_antigen_presentation1.58169497
35MP0005451_abnormal_body_composition1.57074069
36MP0009333_abnormal_splenocyte_physiolog1.54269618
37MP0003186_abnormal_redox_activity1.49448328
38* MP0009643_abnormal_urine_homeostasis1.48579485
39MP0009697_abnormal_copulation1.44171846
40MP0002019_abnormal_tumor_incidence1.40835140
41MP0003763_abnormal_thymus_physiology1.34983442
42MP0008057_abnormal_DNA_replication1.29341957
43MP0003656_abnormal_erythrocyte_physiolo1.28520716
44MP0003567_abnormal_fetal_cardiomyocyte1.27469286
45MP0000689_abnormal_spleen_morphology1.25518139
46MP0003011_delayed_dark_adaptation1.23578512
47MP0001730_embryonic_growth_arrest1.22440600
48MP0000313_abnormal_cell_death1.19665488
49MP0002398_abnormal_bone_marrow1.18454420
50MP0000598_abnormal_liver_morphology1.18237045
51MP0005636_abnormal_mineral_homeostasis1.18061552
52MP0002722_abnormal_immune_system1.13850252
53MP0006036_abnormal_mitochondrial_physio1.09906889
54MP0000703_abnormal_thymus_morphology1.09559286
55MP0001800_abnormal_humoral_immune1.09135385
56MP0000358_abnormal_cell_content/1.07018166
57MP0005647_abnormal_sex_gland1.05575729
58MP0002429_abnormal_blood_cell1.05224734
59MP0002148_abnormal_hypersensitivity_rea1.04042927
60MP0009278_abnormal_bone_marrow1.02262887
61MP0009764_decreased_sensitivity_to1.00596732
62MP0002132_abnormal_respiratory_system0.98243201
63MP0006292_abnormal_olfactory_placode0.97762771
64MP0003705_abnormal_hypodermis_morpholog0.97629486
65MP0000716_abnormal_immune_system0.96355310
66MP0009763_increased_sensitivity_to0.96210505
67MP0005000_abnormal_immune_tolerance0.94534558
68MP0000604_amyloidosis0.93719798
69MP0000350_abnormal_cell_proliferation0.92970214
70MP0005670_abnormal_white_adipose0.91489290
71MP0005397_hematopoietic_system_phenotyp0.91460102
72MP0001545_abnormal_hematopoietic_system0.91460102
73MP0001529_abnormal_vocalization0.90268266
74MP0005084_abnormal_gallbladder_morpholo0.89696432
75MP0009642_abnormal_blood_homeostasis0.89207275
76MP0008469_abnormal_protein_level0.88269547
77MP0002420_abnormal_adaptive_immunity0.87684725
78MP0001819_abnormal_immune_cell0.87634985
79MP0005380_embryogenesis_phenotype0.87328958
80MP0001672_abnormal_embryogenesis/_devel0.87328958
81MP0005220_abnormal_exocrine_pancreas0.85657471
82MP0002876_abnormal_thyroid_physiology0.85556516
83MP0002080_prenatal_lethality0.85093039
84MP0002006_tumorigenesis0.84746928
85MP0005408_hypopigmentation0.84619538
86MP0001756_abnormal_urination0.83203458
87MP0002078_abnormal_glucose_homeostasis0.82404799
88MP0010307_abnormal_tumor_latency0.81779016
89MP0005376_homeostasis/metabolism_phenot0.81561939
90MP0002254_reproductive_system_inflammat0.81068010
91MP0002452_abnormal_antigen_presenting0.80687257
92MP0002653_abnormal_ependyma_morphology0.80543388
93MP0002723_abnormal_immune_serum0.79124868
94MP0004043_abnormal_pH_regulation0.77357117
95MP0009765_abnormal_xenobiotic_induced0.76124233
96MP0000747_muscle_weakness0.75743477
97MP0008877_abnormal_DNA_methylation0.75419578
98MP0001661_extended_life_span0.75210692
99MP0002166_altered_tumor_susceptibility0.75162661
100MP0004808_abnormal_hematopoietic_stem0.74762077
101MP0005646_abnormal_pituitary_gland0.74630323
102MP0000490_abnormal_crypts_of0.73984156
103MP0005535_abnormal_body_temperature0.73356625
104MP0002971_abnormal_brown_adipose0.72784055
105MP0004130_abnormal_muscle_cell0.72560467
106MP0000372_irregular_coat_pigmentation0.72355931
107MP0001881_abnormal_mammary_gland0.72284440
108MP0006035_abnormal_mitochondrial_morpho0.72107922
109MP0003984_embryonic_growth_retardation0.71698497
110MP0010368_abnormal_lymphatic_system0.71690696
111MP0005266_abnormal_metabolism0.71604756
112MP0002088_abnormal_embryonic_growth/wei0.69993094
113MP0005025_abnormal_response_to0.69886224
114MP0001929_abnormal_gametogenesis0.69806865
115MP0005334_abnormal_fat_pad0.67399218
116MP0002136_abnormal_kidney_physiology0.65109319
117MP0003329_amyloid_beta_deposits0.56756236
118MP0003690_abnormal_glial_cell0.56651302
119MP0002837_dystrophic_cardiac_calcinosis0.55787045
120MP0005448_abnormal_energy_balance0.51612899
121MP0003718_maternal_effect0.51309334
122MP0009053_abnormal_anal_canal0.50453782
123MP0005666_abnormal_adipose_tissue0.50375784
124MP0000639_abnormal_adrenal_gland0.50345995
125MP0005395_other_phenotype0.49659205
126MP0003638_abnormal_response/metabolism_0.49446140
127MP0002928_abnormal_bile_duct0.48488840
128MP0001765_abnormal_ion_homeostasis0.45432521
129MP0003953_abnormal_hormone_level0.43889566
130MP0002822_catalepsy0.43761433
131MP0003724_increased_susceptibility_to0.42638915
132MP0008873_increased_physiological_sensi0.42531149
133MP0009672_abnormal_birth_weight0.41956037
134MP0005464_abnormal_platelet_physiology0.41264882
135MP0000230_abnormal_systemic_arterial0.41188491
136MP0008872_abnormal_physiological_respon0.40214389
137MP0008874_decreased_physiological_sensi0.39746088
138MP0004782_abnormal_surfactant_physiolog0.39531780
139MP0005058_abnormal_lysosome_morphology0.38806454
140MP0002796_impaired_skin_barrier0.34914093
141MP0003075_altered_response_to0.32662451
142MP0002970_abnormal_white_adipose0.31773415
143MP0005166_decreased_susceptibility_to0.31660748
144MP0009115_abnormal_fat_cell0.31392627
145MP0002168_other_aberrant_phenotype0.30877662
146MP0003436_decreased_susceptibility_to0.30769314
147MP0001853_heart_inflammation0.29108816
148MP0004264_abnormal_extraembryonic_tissu0.28941795
149MP0004147_increased_porphyrin_level0.28682119
150MP0009384_cardiac_valve_regurgitation0.26853805
151MP0001845_abnormal_inflammatory_respons0.26808653
152MP0004381_abnormal_hair_follicle0.26089600
153MP0000579_abnormal_nail_morphology0.26005935
154* MP0002135_abnormal_kidney_morphology0.25701325
155MP0002269_muscular_atrophy0.25244222
156MP0001944_abnormal_pancreas_morphology0.25058880
157MP0000249_abnormal_blood_vessel0.24938272
158MP0003959_abnormal_lean_body0.24539232

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.29339556
2Intrahepatic cholestasis (HP:0001406)6.93841549
3Deep venous thrombosis (HP:0002625)6.74312182
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.41577113
5Prolonged partial thromboplastin time (HP:0003645)6.04916084
6Hypobetalipoproteinemia (HP:0003563)6.01517690
7Xanthomatosis (HP:0000991)5.99659597
8Hyperlipoproteinemia (HP:0010980)5.22587914
9Hyperammonemia (HP:0001987)4.80944286
10Complement deficiency (HP:0004431)4.79582934
11Hyperglycinemia (HP:0002154)4.71871303
12Hyperglycinuria (HP:0003108)4.55453633
13Hypolipoproteinemia (HP:0010981)4.46824348
14Joint hemorrhage (HP:0005261)4.40946492
15Abnormality of glycine metabolism (HP:0010895)4.40291101
16Abnormality of serine family amino acid metabolism (HP:0010894)4.40291101
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40013546
18* Ketosis (HP:0001946)4.34532361
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.32506911
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.30043128
21Abnormality of methionine metabolism (HP:0010901)4.19585972
22Epidermoid cyst (HP:0200040)4.17269621
23Abnormality of the common coagulation pathway (HP:0010990)4.11059074
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.08944684
25Hypoglycemic coma (HP:0001325)4.08781617
26Fat malabsorption (HP:0002630)3.98889362
27Hypoalphalipoproteinemia (HP:0003233)3.87081358
28Abnormality of pyrimidine metabolism (HP:0004353)3.84005768
29Panhypogammaglobulinemia (HP:0003139)3.78176596
30Abnormality of fatty-acid metabolism (HP:0004359)3.77376718
31Microvesicular hepatic steatosis (HP:0001414)3.71507811
32Abnormality of the intrinsic pathway (HP:0010989)3.62639613
33Conjugated hyperbilirubinemia (HP:0002908)3.50769813
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.50358680
35Ketoacidosis (HP:0001993)3.49192280
36Abnormality of complement system (HP:0005339)3.44623337
37Hepatocellular necrosis (HP:0001404)3.40346966
38Hyperbilirubinemia (HP:0002904)3.35334641
39Abnormality of nucleobase metabolism (HP:0010932)3.34852271
40Delayed CNS myelination (HP:0002188)3.31939950
41Abnormality of serum amino acid levels (HP:0003112)3.31688910
42Hypercholesterolemia (HP:0003124)3.29874438
43Gout (HP:0001997)3.28404899
44Ragged-red muscle fibers (HP:0003200)3.27140314
45Reduced antithrombin III activity (HP:0001976)3.24137959
46Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22174310
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22174310
48Hepatic necrosis (HP:0002605)3.21755510
49Agammaglobulinemia (HP:0004432)3.20697309
50Increased muscle lipid content (HP:0009058)3.17378198
51Increased intramyocellular lipid droplets (HP:0012240)3.13272557
52Abnormality of purine metabolism (HP:0004352)3.10275523
53Steatorrhea (HP:0002570)3.05162181
54Increased serum lactate (HP:0002151)3.04887696
55Abnormal mitochondria in muscle tissue (HP:0008316)3.04555342
56Increased CSF lactate (HP:0002490)3.02576084
57Progressive muscle weakness (HP:0003323)2.99720054
58Mitochondrial inheritance (HP:0001427)2.96781440
59Acute encephalopathy (HP:0006846)2.95085854
60Abnormal number of erythroid precursors (HP:0012131)2.93000453
61Hepatocellular carcinoma (HP:0001402)2.92373317
62Lactic acidosis (HP:0003128)2.91796338
63Lethargy (HP:0001254)2.91654719
64* Metabolic acidosis (HP:0001942)2.90248337
65Type I transferrin isoform profile (HP:0003642)2.86718821
66Lipid accumulation in hepatocytes (HP:0006561)2.82099516
67Colon cancer (HP:0003003)2.80777530
683-Methylglutaconic aciduria (HP:0003535)2.80410067
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78899565
70* Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77649820
71* Dicarboxylic aciduria (HP:0003215)2.77649820
72Birth length less than 3rd percentile (HP:0003561)2.77632710
73Generalized aminoaciduria (HP:0002909)2.75003154
74Spontaneous abortion (HP:0005268)2.71931403
75Acute necrotizing encephalopathy (HP:0006965)2.71120792
76Vascular calcification (HP:0004934)2.70035903
77Testicular atrophy (HP:0000029)2.69844699
78Cerebral edema (HP:0002181)2.69670234
79Abnormality of cells of the erythroid lineage (HP:0012130)2.66715205
80Hypochromic microcytic anemia (HP:0004840)2.61997572
81Increased hepatocellular lipid droplets (HP:0006565)2.61237282
82Skin nodule (HP:0200036)2.61060324
83Myocardial infarction (HP:0001658)2.59789202
84Methylmalonic aciduria (HP:0012120)2.52895010
85Hypoglycemic seizures (HP:0002173)2.48758145
86Irritability (HP:0000737)2.45725465
87IgM deficiency (HP:0002850)2.45142843
88Renal Fanconi syndrome (HP:0001994)2.42670825
89Pancytopenia (HP:0001876)2.42016613
90Systemic lupus erythematosus (HP:0002725)2.41841983
91Cerebral palsy (HP:0100021)2.41772382
92Acanthocytosis (HP:0001927)2.39859424
93Neonatal onset (HP:0003623)2.39842927
94Proximal tubulopathy (HP:0000114)2.39795277
95Abnormal gallbladder morphology (HP:0012437)2.38158487
96Cardiovascular calcification (HP:0011915)2.37345420
97Abnormality of glycolysis (HP:0004366)2.37169991
98Malnutrition (HP:0004395)2.37011977
99Vomiting (HP:0002013)2.36854755
100Increased serum pyruvate (HP:0003542)2.36079447
101Exercise intolerance (HP:0003546)2.34347837
102Abnormal protein glycosylation (HP:0012346)2.34040935
103Abnormal glycosylation (HP:0012345)2.34040935
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34040935
105Abnormal protein N-linked glycosylation (HP:0012347)2.34040935
106Abnormality of T cell physiology (HP:0011840)2.33993373
107Multiple enchondromatosis (HP:0005701)2.33569276
108Methylmalonic acidemia (HP:0002912)2.32972194
109Cholelithiasis (HP:0001081)2.32628528
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29519123
111Late onset (HP:0003584)2.28013148
112Alkalosis (HP:0001948)2.27227306
113Enlarged kidneys (HP:0000105)2.25948860
114Hyperuricemia (HP:0002149)2.25463136
115Increased purine levels (HP:0004368)2.25463136
116Colitis (HP:0002583)2.24924872
117Pancreatitis (HP:0001733)2.23235865
118Brushfield spots (HP:0001088)2.20125195
119Mitral stenosis (HP:0001718)2.19192380
120Abnormal gallbladder physiology (HP:0012438)2.18271847
121Cholecystitis (HP:0001082)2.18271847
122Glycosuria (HP:0003076)2.16156573
123Abnormality of urine glucose concentration (HP:0011016)2.16156573
124Severe combined immunodeficiency (HP:0004430)2.12959401
125Glomerulonephritis (HP:0000099)2.12777806
126Sensorimotor neuropathy (HP:0007141)2.12490316
127Aplastic anemia (HP:0001915)2.10299566
128Hyperinsulinemic hypoglycemia (HP:0000825)2.09053657
129Abnormal delayed hypersensitivity skin test (HP:0002963)2.08948408
130Hydroxyprolinuria (HP:0003080)2.07882380
131Abnormality of proline metabolism (HP:0010907)2.07882380
132Rickets (HP:0002748)2.07421591
133Ependymoma (HP:0002888)2.05527727
134Progressive macrocephaly (HP:0004481)2.01325260
135Rhabdomyolysis (HP:0003201)2.00116800
136B lymphocytopenia (HP:0010976)1.99122672
137Renal cortical cysts (HP:0000803)1.99091703
138Esophageal varix (HP:0002040)1.98531544
139Abnormal cartilage morphology (HP:0002763)1.98316533
140Amyloidosis (HP:0011034)1.98295454
141Thrombophlebitis (HP:0004418)1.98281844
142Respiratory difficulties (HP:0002880)1.98146736
143Abnormality of the preputium (HP:0100587)1.97159920
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96724560
145Abnormal enzyme/coenzyme activity (HP:0012379)1.96681668
146Abnormality of the heme biosynthetic pathway (HP:0010472)1.96653212
147Poikilocytosis (HP:0004447)1.95434429
148Abnormality of the gallbladder (HP:0005264)1.95376283
149Combined immunodeficiency (HP:0005387)1.94405061
150Recurrent gram-negative bacterial infections (HP:0005420)1.93876282
151Menorrhagia (HP:0000132)1.92752576
152Emotional lability (HP:0000712)1.90686423
153Abnormality of transition element cation homeostasis (HP:0011030)1.90563173
154Reticulocytopenia (HP:0001896)1.89767938
155Abnormality of iron homeostasis (HP:0011031)1.88451893
156Nausea (HP:0002018)1.87654324
157Gingival bleeding (HP:0000225)1.87603968
158Elevated hepatic transaminases (HP:0002910)1.87536926
159Mesangial abnormality (HP:0001966)1.86751315
160Recurrent viral infections (HP:0004429)1.85014862
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84776215
162Abnormality of alanine metabolism (HP:0010916)1.84776215
163Hyperalaninemia (HP:0003348)1.84776215
164Neutropenia (HP:0001875)1.84366960
165Abnormality of vitamin metabolism (HP:0100508)1.83229521
166Abnormality of B cell number (HP:0010975)1.82896456
167Hypophosphatemic rickets (HP:0004912)1.80469939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.32735694
2VRK25.20047036
3FGFR44.24466285
4SIK14.18017705
5ERN14.11555918
6BUB13.27404827
7SMG13.07044112
8INSRR2.94718126
9TAOK32.86527631
10CDC72.74937254
11ERBB42.60656333
12PKN22.50347714
13FLT32.41269877
14ZAK2.33142812
15VRK12.32276789
16SRPK12.20643267
17PBK2.19439841
18TLK12.18883874
19MST1R2.04681790
20MAP2K42.03801233
21MAP4K22.02511714
22BMPR1B1.96505542
23MAPK111.92806342
24CDK81.86951355
25NUAK11.84382677
26KIT1.79569437
27PIK3CG1.79037328
28TRIB31.62171207
29TYK21.54650385
30PINK11.53225024
31TAF11.52879202
32ABL21.50158538
33TTK1.44451160
34CDK191.43809141
35TESK21.42179565
36NEK91.41836104
37TSSK61.39915335
38LATS11.39368206
39ATR1.37866939
40MAP4K11.37296779
41NME11.37199747
42FRK1.29481309
43STK38L1.28946976
44KDR1.28608333
45PTK61.26657019
46EIF2AK11.25924468
47MAP2K31.24919726
48MAP3K71.23944365
49WNK31.22348732
50TNK21.22143479
51PRKAA21.18907370
52WNK41.17720999
53JAK21.17602011
54DAPK21.15504866
55PLK31.10276487
56PLK41.05899522
57CDK70.99557331
58RPS6KA50.98870770
59TGFBR10.97799158
60STK40.97021058
61MAP3K30.96883044
62CHEK20.96281734
63GRK60.95818299
64PDK40.95350220
65PDK30.95350220
66FGFR20.94888724
67MST40.89577175
68AURKA0.88857523
69CLK10.88316770
70MAPK40.87383307
71TBK10.87057420
72PLK10.86562002
73SCYL20.86315634
74OXSR10.85035159
75MET0.83850006
76MAPK150.83571420
77PRPF4B0.83207204
78PRKCZ0.82960419
79IRAK30.82612016
80AURKB0.82510231
81MAP2K60.79068593
82MAPK120.79027485
83TIE10.78826024
84MKNK10.78081359
85ERBB20.76398775
86DAPK10.75733828
87MAP3K140.75171406
88PRKAA10.74867650
89JAK10.74848094
90JAK30.74113504
91RPS6KB20.73364605
92CDK90.71859347
93PRKACG0.71284540
94NEK10.70066769
95GSK3A0.69363122
96MAP3K110.68712631
97EIF2AK20.68423385
98DYRK20.66712321
99MAP3K100.66002321
100STK160.64311994
101PHKG10.63433323
102PHKG20.63433323
103DYRK1B0.63274436
104TAOK20.62073331
105FES0.61616936
106CAMK2G0.61152840
107CAMK1D0.60059110
108SGK30.59888868
109TGFBR20.58581225
110PIM10.57888717
111PIM20.56799076
112SYK0.56346674
113IKBKB0.55408559
114CDK60.55392197
115EPHB10.54603954
116ATM0.54261945
117TXK0.53332282
118PASK0.52853399
119BTK0.51635276
120MAP3K80.50558683
121MAPKAPK50.50553451
122CSNK2A20.50547706
123CSK0.49884199
124LRRK20.49471631
125EIF2AK30.49375169
126CHEK10.49369860
127PTK20.49320897
128SGK20.48760705
129EEF2K0.48160964
130SGK4940.47749487
131SGK2230.47749487
132PDK20.47443426
133AKT20.47322808
134CDK40.47230058
135PDPK10.46968681
136CSNK2A10.46429744
137CSF1R0.45439029
138MAPK70.44897204
139ACVR1B0.43309703
140CSNK1G10.42543210
141EPHA30.40998376
142BRSK10.39972331
143NEK20.39965651
144PRKCQ0.39298509
145MAP3K50.37873089
146LYN0.36646402
147MAP2K10.36430981
148GRK10.36365839
149ITK0.35983871
150CDK20.34751636
151BRSK20.34599602
152IGF1R0.34574892
153AKT30.34184582
154IKBKE0.33706057
155PRKCI0.33466721
156MAP3K60.33258123
157DAPK30.32688083
158RIPK10.32453186
159MTOR0.30121752
160CDK30.30019309
161CAMK40.28991028
162FGFR30.28930889
163PRKCG0.28867320
164PDK10.26988389
165MAP2K20.26803188
166RET0.26577131
167MYLK0.24242362
168PRKCA0.23479241
169NME20.23362962
170IRAK20.20966253
171IRAK10.20501890
172EGFR0.19675136
173PIK3CA0.19043303
174CSNK1G30.18640802

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25506591
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37008824
3Nitrogen metabolism_Homo sapiens_hsa009103.33871678
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25197180
5DNA replication_Homo sapiens_hsa030302.95996242
6Arginine biosynthesis_Homo sapiens_hsa002202.90167120
7Proteasome_Homo sapiens_hsa030502.81885164
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76938823
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63816532
10* Tryptophan metabolism_Homo sapiens_hsa003802.60422555
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59960081
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59023737
13* Fatty acid degradation_Homo sapiens_hsa000712.48911124
14Complement and coagulation cascades_Homo sapiens_hsa046102.44597200
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33084289
16Butanoate metabolism_Homo sapiens_hsa006502.31452392
17Peroxisome_Homo sapiens_hsa041462.17182496
18Propanoate metabolism_Homo sapiens_hsa006402.16926834
19Mismatch repair_Homo sapiens_hsa034302.09307297
20Base excision repair_Homo sapiens_hsa034102.06693228
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05884383
22Ribosome_Homo sapiens_hsa030101.92975332
23Fatty acid metabolism_Homo sapiens_hsa012121.87064632
24Chemical carcinogenesis_Homo sapiens_hsa052041.87016743
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85229491
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.84247960
27Homologous recombination_Homo sapiens_hsa034401.84100123
28Histidine metabolism_Homo sapiens_hsa003401.83547311
29PPAR signaling pathway_Homo sapiens_hsa033201.82970793
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80727688
31beta-Alanine metabolism_Homo sapiens_hsa004101.79709363
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78882647
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78723046
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.78560226
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77473948
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70886520
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69123289
38Caffeine metabolism_Homo sapiens_hsa002321.68409259
39Retinol metabolism_Homo sapiens_hsa008301.63329903
40Selenocompound metabolism_Homo sapiens_hsa004501.61898990
41RNA polymerase_Homo sapiens_hsa030201.59909992
42Non-homologous end-joining_Homo sapiens_hsa034501.58374040
43Spliceosome_Homo sapiens_hsa030401.56683009
44Pyruvate metabolism_Homo sapiens_hsa006201.53013576
45Phenylalanine metabolism_Homo sapiens_hsa003601.51159396
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50834816
47Staphylococcus aureus infection_Homo sapiens_hsa051501.48068743
48Parkinsons disease_Homo sapiens_hsa050121.46616210
49Bile secretion_Homo sapiens_hsa049761.43968276
50Sulfur metabolism_Homo sapiens_hsa009201.43965387
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.39047257
52Fatty acid elongation_Homo sapiens_hsa000621.36777291
53Tyrosine metabolism_Homo sapiens_hsa003501.35510527
54Folate biosynthesis_Homo sapiens_hsa007901.33418943
55Nucleotide excision repair_Homo sapiens_hsa034201.32137834
56Starch and sucrose metabolism_Homo sapiens_hsa005001.30021053
57Biosynthesis of amino acids_Homo sapiens_hsa012301.28854242
58Carbon metabolism_Homo sapiens_hsa012001.28473949
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.28439777
60Fanconi anemia pathway_Homo sapiens_hsa034601.23586622
61Primary immunodeficiency_Homo sapiens_hsa053401.15914645
62Steroid biosynthesis_Homo sapiens_hsa001001.11824963
63ABC transporters_Homo sapiens_hsa020101.11312674
64Fat digestion and absorption_Homo sapiens_hsa049751.10697802
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10574625
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.07434800
67Arginine and proline metabolism_Homo sapiens_hsa003301.05125105
68RNA degradation_Homo sapiens_hsa030181.04565865
69Sulfur relay system_Homo sapiens_hsa041221.03969853
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02732636
71RNA transport_Homo sapiens_hsa030131.02127196
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99198420
73Vitamin digestion and absorption_Homo sapiens_hsa049770.94565644
74Vitamin B6 metabolism_Homo sapiens_hsa007500.91710305
75Huntingtons disease_Homo sapiens_hsa050160.90978842
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86706078
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86414580
78One carbon pool by folate_Homo sapiens_hsa006700.84689759
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82906187
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78761634
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78286107
82Glutathione metabolism_Homo sapiens_hsa004800.77760499
83Purine metabolism_Homo sapiens_hsa002300.77093878
84Basal transcription factors_Homo sapiens_hsa030220.73406654
85* Lysine degradation_Homo sapiens_hsa003100.73307933
86Glycerolipid metabolism_Homo sapiens_hsa005610.70683160
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.68505136
88Pentose phosphate pathway_Homo sapiens_hsa000300.66168016
89Alzheimers disease_Homo sapiens_hsa050100.64582019
90Cell cycle_Homo sapiens_hsa041100.63501406
91Asthma_Homo sapiens_hsa053100.62680498
92N-Glycan biosynthesis_Homo sapiens_hsa005100.56616298
93Antigen processing and presentation_Homo sapiens_hsa046120.53902360
94* Metabolic pathways_Homo sapiens_hsa011000.52879720
95Autoimmune thyroid disease_Homo sapiens_hsa053200.46144022
96Fatty acid biosynthesis_Homo sapiens_hsa000610.45860893
97Allograft rejection_Homo sapiens_hsa053300.41553681
98Epstein-Barr virus infection_Homo sapiens_hsa051690.36520808
99Fructose and mannose metabolism_Homo sapiens_hsa000510.35886163
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32564841
101Galactose metabolism_Homo sapiens_hsa000520.32132906
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31861805
103Herpes simplex infection_Homo sapiens_hsa051680.31838392
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25743630
105Prion diseases_Homo sapiens_hsa050200.23927401
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22627444
107Insulin resistance_Homo sapiens_hsa049310.20902915
108Linoleic acid metabolism_Homo sapiens_hsa005910.20889892
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.19511044
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.13288301
111Glucagon signaling pathway_Homo sapiens_hsa049220.07839817
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06631654
113AMPK signaling pathway_Homo sapiens_hsa041520.01654699
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00817926
115Lysosome_Homo sapiens_hsa04142-0.2425875
116Other glycan degradation_Homo sapiens_hsa00511-0.2243988
117Hepatitis C_Homo sapiens_hsa05160-0.2057552
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2021082
119Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2005677
120Protein digestion and absorption_Homo sapiens_hsa04974-0.1980249
121Oxidative phosphorylation_Homo sapiens_hsa00190-0.1940047
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1907559
123Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1901218
124Pyrimidine metabolism_Homo sapiens_hsa00240-0.1771302
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1729361
126Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1608794
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1434487
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1382853
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1372728
130Insulin signaling pathway_Homo sapiens_hsa04910-0.1137808
131Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0953150
132Renin-angiotensin system_Homo sapiens_hsa04614-0.0913203
133Regulation of autophagy_Homo sapiens_hsa04140-0.0466596

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