GCG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-alpha-amino acid transmembrane transport (GO:1902475)7.11756270
2peptide hormone processing (GO:0016486)6.96852528
3endocrine pancreas development (GO:0031018)6.21729107
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.20940886
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.94087113
6COPII vesicle coating (GO:0048208)5.91846953
7glandular epithelial cell differentiation (GO:0002067)5.87336157
8negative regulation of JUN kinase activity (GO:0043508)5.60770379
9* positive regulation of insulin secretion (GO:0032024)5.39624406
10positive regulation of vesicle fusion (GO:0031340)5.33029742
11protein retention in ER lumen (GO:0006621)5.32762299
12glandular epithelial cell development (GO:0002068)4.97448166
13cellular ketone body metabolic process (GO:0046950)4.89873614
14type B pancreatic cell development (GO:0003323)4.88166628
15response to dietary excess (GO:0002021)4.84803353
16toxin metabolic process (GO:0009404)4.84520300
17insulin secretion (GO:0030073)4.82277180
18negative regulation of digestive system process (GO:0060457)4.79742912
19positive regulation of amino acid transport (GO:0051957)4.74804099
20glycerophospholipid catabolic process (GO:0046475)4.72441063
21vesicle coating (GO:0006901)4.60862330
22epithelial cell fate commitment (GO:0072148)4.59270427
23auditory receptor cell differentiation (GO:0042491)4.57953041
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54198066
25inositol phosphate catabolic process (GO:0071545)4.53485024
26glycine transport (GO:0015816)4.50455600
27regulation of extracellular matrix disassembly (GO:0010715)4.50035127
28sequestering of metal ion (GO:0051238)4.44718912
29protein autoprocessing (GO:0016540)4.36201771
30inositol phosphate dephosphorylation (GO:0046855)4.34182010
31phosphorylated carbohydrate dephosphorylation (GO:0046838)4.34182010
32* positive regulation of peptide hormone secretion (GO:0090277)4.33094272
33ketone body metabolic process (GO:1902224)4.32498443
34activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.30137293
35growth hormone secretion (GO:0030252)4.28952195
36cellular response to vitamin D (GO:0071305)4.22219478
37signal peptide processing (GO:0006465)4.20117100
38* regulation of insulin secretion (GO:0050796)4.18204240
39nitric oxide biosynthetic process (GO:0006809)4.17839629
40* positive regulation of peptide secretion (GO:0002793)4.16717139
41respiratory chain complex IV assembly (GO:0008535)4.15493161
42peptide hormone secretion (GO:0030072)4.13497248
43* positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.08165275
44positive regulation of nuclease activity (GO:0032075)4.05497341
45regulation of type B pancreatic cell apoptotic process (GO:2000674)4.05322922
46peptide secretion (GO:0002790)4.04371537
47cytochrome complex assembly (GO:0017004)4.01056992
48artery smooth muscle contraction (GO:0014824)3.98953587
49astrocyte differentiation (GO:0048708)3.94114001
50protein maturation by protein folding (GO:0022417)3.90192251
51columnar/cuboidal epithelial cell development (GO:0002066)3.80497854
52* regulation of peptide hormone secretion (GO:0090276)3.78338331
53water-soluble vitamin biosynthetic process (GO:0042364)3.74613246
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.73542175
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.72940185
56L-phenylalanine metabolic process (GO:0006558)3.72940185
57* regulation of peptide secretion (GO:0002791)3.70718559
58regulation of nuclease activity (GO:0032069)3.69963501
59polyol catabolic process (GO:0046174)3.65819920
60intra-Golgi vesicle-mediated transport (GO:0006891)3.57370678
61nodal signaling pathway (GO:0038092)3.56008437
62regulation of systemic arterial blood pressure by hormone (GO:0001990)3.55374688
63regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.55374688
64endocrine process (GO:0050886)3.55374688
65ER to Golgi vesicle-mediated transport (GO:0006888)3.53164203
66retinol metabolic process (GO:0042572)3.50973534
67macroautophagy (GO:0016236)3.50776289
68production of molecular mediator involved in inflammatory response (GO:0002532)3.50200166
69pteridine-containing compound biosynthetic process (GO:0042559)3.47834680
70detection of calcium ion (GO:0005513)3.47308015
71neuron fate specification (GO:0048665)3.46789223
72endoplasmic reticulum unfolded protein response (GO:0030968)3.46091690
73exocrine pancreas development (GO:0031017)3.45282588
74hormone secretion (GO:0046879)3.43926161
75regulation of calcium ion-dependent exocytosis (GO:0017158)3.41654581
76tonic smooth muscle contraction (GO:0014820)3.41388057
77cellular response to unfolded protein (GO:0034620)3.40909425
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37156304
79regulation of uterine smooth muscle contraction (GO:0070472)3.35989816
80* positive regulation of hormone secretion (GO:0046887)3.35769015
81cellular response to topologically incorrect protein (GO:0035967)3.35395048
82response to hepatocyte growth factor (GO:0035728)3.33633809
83cellular response to hepatocyte growth factor stimulus (GO:0035729)3.33633809
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.32763928
85peptide transport (GO:0015833)3.31909542
86cellular zinc ion homeostasis (GO:0006882)3.31289322
87* regulation of hormone secretion (GO:0046883)3.30113199
88hormone transport (GO:0009914)3.26428770
89regulation of secondary heart field cardioblast proliferation (GO:0003266)3.23232436
90regulation of cardioblast proliferation (GO:0003264)3.23232436
91eating behavior (GO:0042755)3.20985022
92negative regulation of glycoprotein biosynthetic process (GO:0010561)3.17942539
93ER-nucleus signaling pathway (GO:0006984)3.17790864
94negative regulation of erythrocyte differentiation (GO:0045647)3.15758141
95positive regulation of macroautophagy (GO:0016239)3.15056357
96nitric oxide mediated signal transduction (GO:0007263)3.14720701
97negative regulation of complement activation (GO:0045916)3.13426989
98ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.12731071
99regulation of neurotransmitter uptake (GO:0051580)3.10028833
100embryonic retina morphogenesis in camera-type eye (GO:0060059)3.09548045
101peptide metabolic process (GO:0006518)3.08662155
102regulation of penile erection (GO:0060405)3.06522920
103membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.06374093
104regulation of glucocorticoid secretion (GO:2000849)3.05812701
105ER overload response (GO:0006983)3.05254180
106potassium ion export (GO:0071435)3.04181621
107zinc ion homeostasis (GO:0055069)3.02617774
108* regulation of peptide transport (GO:0090087)3.02544468
109proline transport (GO:0015824)3.02098544
110positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.00215253
111genitalia morphogenesis (GO:0035112)2.99399759
112sphingomyelin metabolic process (GO:0006684)2.97233066
113protein complex biogenesis (GO:0070271)2.97112060
114phenylpropanoid metabolic process (GO:0009698)2.94048876
115positive regulation of uterine smooth muscle contraction (GO:0070474)2.92990884
116alanine transport (GO:0032328)2.90334920
117Golgi organization (GO:0007030)2.89440377
118pancreas development (GO:0031016)2.88481654
119response to endoplasmic reticulum stress (GO:0034976)2.88367024
120erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88207469
121L-phenylalanine catabolic process (GO:0006559)2.88207469
122basic amino acid transport (GO:0015802)2.87432186
123nephron epithelium morphogenesis (GO:0072088)2.86127390
124nephron tubule morphogenesis (GO:0072078)2.86127390
125protein N-linked glycosylation via asparagine (GO:0018279)2.85774088
126* regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.85681032
127magnesium ion transport (GO:0015693)2.85216280
128peptidyl-asparagine modification (GO:0018196)2.84781834
129C-terminal protein lipidation (GO:0006501)2.83882902
130DNA strand renaturation (GO:0000733)2.83624981
131cellular response to vitamin (GO:0071295)2.83564458
132regulation of hexokinase activity (GO:1903299)2.83348081
133regulation of glucokinase activity (GO:0033131)2.83348081
134hair cell differentiation (GO:0035315)2.79796006
135phospholipid catabolic process (GO:0009395)2.78947339
136lactate metabolic process (GO:0006089)2.78375566
137negative regulation of protein activation cascade (GO:2000258)2.75877124
138cardiac left ventricle morphogenesis (GO:0003214)2.75461186
139dendritic spine morphogenesis (GO:0060997)2.74224103
140regulation of autophagic vacuole assembly (GO:2000785)2.74006017
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70916569
142aromatic amino acid family catabolic process (GO:0009074)2.67819603
143inner ear receptor cell differentiation (GO:0060113)2.67182746
144positive regulation of response to nutrient levels (GO:0032109)2.66247890
145positive regulation of response to extracellular stimulus (GO:0032106)2.66247890
146toxin transport (GO:1901998)2.65932588
147regulation of mitochondrial translation (GO:0070129)2.65725664
148positive regulation of meiosis (GO:0045836)2.64967068
149renal tubule morphogenesis (GO:0061333)2.64584804
150mitotic cell cycle arrest (GO:0071850)2.64555869
151inositol phosphate-mediated signaling (GO:0048016)2.63352949
152positive regulation of neurotransmitter transport (GO:0051590)2.62872473
153S-adenosylmethionine metabolic process (GO:0046500)2.60223886
154regulation of Rac protein signal transduction (GO:0035020)2.59404337
155glucosamine-containing compound catabolic process (GO:1901072)2.59151787
156Golgi to endosome transport (GO:0006895)2.58955157
157negative regulation of cAMP-mediated signaling (GO:0043951)2.57848068
158snRNA transcription (GO:0009301)2.57720702
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.56824514
160purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.56824514
161dentate gyrus development (GO:0021542)2.56444486
162somite rostral/caudal axis specification (GO:0032525)2.56322757
163mitochondrial respiratory chain complex assembly (GO:0033108)2.56186163
164phospholipid dephosphorylation (GO:0046839)2.56060286
165C-terminal protein amino acid modification (GO:0018410)2.56058040
166regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.53111960
167regulation of vacuole organization (GO:0044088)2.50961039
168axoneme assembly (GO:0035082)2.50748405
169zinc ion transmembrane transport (GO:0071577)2.50432686
170preassembly of GPI anchor in ER membrane (GO:0016254)2.49777325
171regulation of protein glycosylation (GO:0060049)2.49009765
172COPI coating of Golgi vesicle (GO:0048205)10.1384168
173Golgi transport vesicle coating (GO:0048200)10.1384168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.82074044
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.90092256
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87047845
4GBX2_23144817_ChIP-Seq_PC3_Human2.84490454
5* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.83063527
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.74766719
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33079279
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27385566
9PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.18495676
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.18479025
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10201230
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05452476
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.0038324
14IGF1R_20145208_ChIP-Seq_DFB_Human1.99727126
15NR3C1_23031785_ChIP-Seq_PC12_Mouse1.98249126
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95476985
17HTT_18923047_ChIP-ChIP_STHdh_Human1.86414212
18OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.83172757
19FUS_26573619_Chip-Seq_HEK293_Human1.76322199
20* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70149236
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70037705
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63885383
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59377812
24VDR_22108803_ChIP-Seq_LS180_Human1.58909071
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57555718
26FOXA1_25552417_ChIP-Seq_VCAP_Human1.57119534
27P300_19829295_ChIP-Seq_ESCs_Human1.56364824
28BCAT_22108803_ChIP-Seq_LS180_Human1.50177192
29* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49234960
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48737378
31TAF15_26573619_Chip-Seq_HEK293_Human1.48352374
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47228916
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.47182562
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46091090
35REST_19997604_ChIP-ChIP_NEURONS_Mouse1.45428420
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43413336
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.40905212
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.40726132
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39077197
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38022397
41AR_25329375_ChIP-Seq_VCAP_Human1.36341319
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36130316
43FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36090347
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35847401
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33702113
46P53_22387025_ChIP-Seq_ESCs_Mouse1.32659881
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.31579276
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31346218
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.30969099
50ER_23166858_ChIP-Seq_MCF-7_Human1.30307989
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.28881817
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28170989
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28166479
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28042645
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.27984226
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27077497
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26695994
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26599118
59REST_21632747_ChIP-Seq_MESCs_Mouse1.26336269
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25084160
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24983644
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24623420
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.24075628
64TP53_22573176_ChIP-Seq_HFKS_Human1.23354795
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23125274
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.23010059
67* SOX2_18555785_Chip-Seq_ESCs_Mouse1.21859737
68CDX2_22108803_ChIP-Seq_LS180_Human1.21615592
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.20950556
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.19783243
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18622873
72* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17815248
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17796918
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17655536
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17176086
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17147759
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15262060
78NANOG_19829295_ChIP-Seq_ESCs_Human1.14900692
79SOX2_19829295_ChIP-Seq_ESCs_Human1.14900692
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14738008
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14563070
82CTCF_18555785_Chip-Seq_ESCs_Mouse1.11728635
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11317505
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10416776
85SOX2_20726797_ChIP-Seq_SW620_Human1.10247720
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10016672
87CBP_20019798_ChIP-Seq_JUKART_Human1.09714412
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09714412
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09446079
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09183865
91TCF4_22108803_ChIP-Seq_LS180_Human1.08967666
92* NMYC_18555785_Chip-Seq_ESCs_Mouse1.08398012
93AR_20517297_ChIP-Seq_VCAP_Human1.08153294
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06989698
95STAT3_23295773_ChIP-Seq_U87_Human1.06469587
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05739194
97GATA1_19941826_ChIP-Seq_K562_Human1.05523096
98EWS_26573619_Chip-Seq_HEK293_Human1.05324053
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05120125
100* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04841103
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04825060
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04599980
103EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04201353
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03869916
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02976255
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.02220461
107CLOCK_20551151_ChIP-Seq_293T_Human1.02186725
108* OCT4_18555785_Chip-Seq_ESCs_Mouse1.01526605
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01446686
110* P300_18555785_Chip-Seq_ESCs_Mouse1.00657596
111CRX_20693478_ChIP-Seq_RETINA_Mouse0.99842605
112RUNX2_22187159_ChIP-Seq_PCA_Human0.99393257
113TFEB_21752829_ChIP-Seq_HELA_Human0.99307413
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.99105926
115NCOR_22424771_ChIP-Seq_293T_Human0.98045255
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97946362
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97388164
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.97087924
119ZFX_18555785_Chip-Seq_ESCs_Mouse0.97053981
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.96267347
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95913165
122SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95089426
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93936733
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.93705388
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.93266538
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93045450
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92969066
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91863795
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91574790
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90406690
131GATA3_27048872_Chip-Seq_THYMUS_Human0.90222911
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89275212
133E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88802884
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88503895
135FOXH1_21741376_ChIP-Seq_ESCs_Human0.87930781
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86400928
137GABP_17652178_ChIP-ChIP_JURKAT_Human0.86200466
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84986657
139GATA4_25053715_ChIP-Seq_YYC3_Human0.84716300
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.81918929
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81768956
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80839780
143CHD1_26751641_Chip-Seq_LNCaP_Human0.80792200
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79906238
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78891920
146SMAD4_21799915_ChIP-Seq_A2780_Human0.77653078
147ZNF274_21170338_ChIP-Seq_K562_Hela0.77584659
148AR_19668381_ChIP-Seq_PC3_Human0.76252473
149TDRD3_21172665_ChIP-Seq_MCF-7_Human0.75678125
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75112647
151BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.74551633
152ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.73958796
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73004048
154DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72617571
155EZH2_27294783_Chip-Seq_ESCs_Mouse0.72613527
156ESR1_21235772_ChIP-Seq_MCF-7_Human0.72269631
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.70761505
158FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70761505
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.70350337
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70341816
161RARB_27405468_Chip-Seq_BRAIN_Mouse0.70331119
162TCF4_23295773_ChIP-Seq_U87_Human0.68774263
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68650961
164ERG_20517297_ChIP-Seq_VCAP_Human0.68518559
165NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.68302821
166* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.68293436
167FLI1_21867929_ChIP-Seq_TH2_Mouse0.67939718
168FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67408491
169ISL1_27105846_Chip-Seq_CPCs_Mouse0.66344053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue6.91660018
2MP0003183_abnormal_peptide_metabolism5.17092033
3MP0003195_calcinosis4.78969310
4MP0005379_endocrine/exocrine_gland_phen4.24354648
5MP0002909_abnormal_adrenal_gland4.00269987
6MP0005645_abnormal_hypothalamus_physiol3.95251920
7MP0000003_abnormal_adipose_tissue3.88491078
8MP0002139_abnormal_hepatobiliary_system3.78233804
9MP0002877_abnormal_melanocyte_morpholog3.41741227
10MP0002837_dystrophic_cardiac_calcinosis3.35793085
11MP0002693_abnormal_pancreas_physiology3.20124363
12* MP0001944_abnormal_pancreas_morphology3.18494590
13MP0002254_reproductive_system_inflammat2.73971669
14MP0003122_maternal_imprinting2.67644829
15MP0005220_abnormal_exocrine_pancreas2.61032135
16MP0010386_abnormal_urinary_bladder2.60634074
17MP0004043_abnormal_pH_regulation2.49486752
18MP0002876_abnormal_thyroid_physiology2.42022518
19MP0003283_abnormal_digestive_organ2.40632190
20MP0000678_abnormal_parathyroid_gland2.39012750
21MP0009780_abnormal_chondrocyte_physiolo2.16313948
22MP0008877_abnormal_DNA_methylation2.15003745
23MP0005084_abnormal_gallbladder_morpholo2.02651139
24MP0010329_abnormal_lipoprotein_level1.93318179
25* MP0002078_abnormal_glucose_homeostasis1.92961219
26MP0006072_abnormal_retinal_apoptosis1.90745676
27MP0004270_analgesia1.86539244
28MP0002163_abnormal_gland_morphology1.85318388
29MP0009046_muscle_twitch1.85299563
30MP0004264_abnormal_extraembryonic_tissu1.84334541
31MP0002638_abnormal_pupillary_reflex1.82785925
32MP0003959_abnormal_lean_body1.78985869
33MP0002138_abnormal_hepatobiliary_system1.76769199
34MP0001765_abnormal_ion_homeostasis1.75408963
35MP0005375_adipose_tissue_phenotype1.71580359
36MP0002234_abnormal_pharynx_morphology1.71464652
37MP0008961_abnormal_basal_metabolism1.70803154
38MP0001986_abnormal_taste_sensitivity1.69892266
39MP0005365_abnormal_bile_salt1.59827880
40MP0002938_white_spotting1.56836265
41MP0003787_abnormal_imprinting1.55513836
42MP0003172_abnormal_lysosome_physiology1.51555630
43MP0006054_spinal_hemorrhage1.46080312
44MP0005257_abnormal_intraocular_pressure1.44460090
45MP0003300_gastrointestinal_ulcer1.42373490
46MP0005174_abnormal_tail_pigmentation1.37565249
47MP0001501_abnormal_sleep_pattern1.36673991
48MP0005248_abnormal_Harderian_gland1.32471681
49MP0002896_abnormal_bone_mineralization1.32405059
50MP0005551_abnormal_eye_electrophysiolog1.29305165
51MP0003121_genomic_imprinting1.27819826
52MP0003953_abnormal_hormone_level1.25525599
53MP0003123_paternal_imprinting1.24131679
54* MP0001756_abnormal_urination1.22841271
55MP0002751_abnormal_autonomic_nervous1.20718231
56MP0009745_abnormal_behavioral_response1.19152960
57MP0002928_abnormal_bile_duct1.18696948
58MP0004133_heterotaxia1.17947393
59MP0005636_abnormal_mineral_homeostasis1.13925649
60MP0003252_abnormal_bile_duct1.13241879
61MP0000613_abnormal_salivary_gland1.13102947
62MP0000631_abnormal_neuroendocrine_gland1.10904309
63MP0009643_abnormal_urine_homeostasis1.07974680
64MP0000015_abnormal_ear_pigmentation1.06055289
65MP0006292_abnormal_olfactory_placode1.04087172
66MP0001984_abnormal_olfaction1.03609621
67MP0000639_abnormal_adrenal_gland0.99811112
68MP0004019_abnormal_vitamin_homeostasis0.99367975
69MP0005408_hypopigmentation0.98979281
70MP0002118_abnormal_lipid_homeostasis0.98344124
71MP0001905_abnormal_dopamine_level0.97695933
72MP0003868_abnormal_feces_composition0.96229319
73MP0002064_seizures0.95291944
74MP0003011_delayed_dark_adaptation0.95263154
75MP0004215_abnormal_myocardial_fiber0.93975931
76MP0000427_abnormal_hair_cycle0.93791970
77MP0000372_irregular_coat_pigmentation0.93084278
78MP0000569_abnormal_digit_pigmentation0.92813053
79MP0006036_abnormal_mitochondrial_physio0.91147378
80MP0010234_abnormal_vibrissa_follicle0.90786385
81MP0000516_abnormal_urinary_system0.90596780
82MP0005367_renal/urinary_system_phenotyp0.90596780
83MP0004145_abnormal_muscle_electrophysio0.90479549
84MP0001270_distended_abdomen0.89988121
85MP0000230_abnormal_systemic_arterial0.86527361
86MP0005058_abnormal_lysosome_morphology0.85668979
87MP0002734_abnormal_mechanical_nocicepti0.85125580
88MP0008872_abnormal_physiological_respon0.85068524
89MP0002272_abnormal_nervous_system0.83530173
90MP0003119_abnormal_digestive_system0.82448247
91MP0002090_abnormal_vision0.82444193
92MP0004147_increased_porphyrin_level0.81769003
93MP0010678_abnormal_skin_adnexa0.81484777
94MP0001502_abnormal_circadian_rhythm0.79378621
95MP0005448_abnormal_energy_balance0.78460741
96MP0001299_abnormal_eye_distance/0.78367214
97MP0002733_abnormal_thermal_nociception0.77098941
98MP0003045_fibrosis0.75079421
99MP0004085_abnormal_heartbeat0.74965682
100MP0004924_abnormal_behavior0.73128987
101MP0005386_behavior/neurological_phenoty0.73128987
102MP0002229_neurodegeneration0.72761941
103MP0002295_abnormal_pulmonary_circulatio0.72427693
104MP0005085_abnormal_gallbladder_physiolo0.71593523
105MP0001968_abnormal_touch/_nociception0.71037679
106MP0000462_abnormal_digestive_system0.69784148
107MP0002168_other_aberrant_phenotype0.69124499
108MP0008875_abnormal_xenobiotic_pharmacok0.67915983
109MP0005253_abnormal_eye_physiology0.67381065
110MP0005075_abnormal_melanosome_morpholog0.66523543
111MP0001661_extended_life_span0.66290504
112MP0002572_abnormal_emotion/affect_behav0.66132473
113MP0005535_abnormal_body_temperature0.65936277
114MP0005452_abnormal_adipose_tissue0.65722864
115MP0003879_abnormal_hair_cell0.64730227
116MP0005670_abnormal_white_adipose0.64014183
117MP0001666_abnormal_nutrient_absorption0.63391421
118MP0002069_abnormal_eating/drinking_beha0.61449127
119MP0005332_abnormal_amino_acid0.61193671
120MP0002184_abnormal_innervation0.59386681
121MP0000538_abnormal_urinary_bladder0.55229349
122MP0003633_abnormal_nervous_system0.54553467
123MP0002177_abnormal_outer_ear0.52272300
124MP0005334_abnormal_fat_pad0.52149348
125MP0002557_abnormal_social/conspecific_i0.51542794
126MP0001529_abnormal_vocalization0.50075036
127MP0003890_abnormal_embryonic-extraembry0.49671657
128MP0005646_abnormal_pituitary_gland0.47688307
129MP0004233_abnormal_muscle_weight0.45766860
130MP0009642_abnormal_blood_homeostasis0.45563308
131MP0002009_preneoplasia0.45105589
132MP0001970_abnormal_pain_threshold0.43985375
133MP0001764_abnormal_homeostasis0.43893019
134MP0009703_decreased_birth_body0.42442779
135MP0000955_abnormal_spinal_cord0.42174114
136MP0002269_muscular_atrophy0.41925001
137MP0009672_abnormal_birth_weight0.41071318
138MP0000428_abnormal_craniofacial_morphol0.40598776
139MP0004885_abnormal_endolymph0.36981593
140MP0002970_abnormal_white_adipose0.36774790

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)8.32849439
2Hyperinsulinemic hypoglycemia (HP:0000825)7.55835585
3Hypoglycemic seizures (HP:0002173)6.57988189
4Hyperglycemia (HP:0003074)6.25639989
5Abnormality of calcium-phosphate metabolism (HP:0100530)5.97784357
6Symptomatic seizures (HP:0011145)5.83568813
7Pancreatic islet-cell hyperplasia (HP:0004510)5.78821483
8Hypoglycemic coma (HP:0001325)5.76166337
9Abnormality of the pancreatic islet cells (HP:0006476)5.38824522
10Abnormality of endocrine pancreas physiology (HP:0012093)5.38824522
11Large for gestational age (HP:0001520)4.92351983
12Ketoacidosis (HP:0001993)4.85988267
13Late onset (HP:0003584)4.71880686
14Retinal atrophy (HP:0001105)4.71876778
15Double outlet right ventricle (HP:0001719)4.67759358
16Congenital malformation of the right heart (HP:0011723)4.67759358
17Insulin-resistant diabetes mellitus (HP:0000831)4.46924563
18Agitation (HP:0000713)4.12891939
19Hyperparathyroidism (HP:0000843)3.63748127
20Dysautonomia (HP:0002459)3.41924423
21Orthostatic hypotension (HP:0001278)3.38359973
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35855521
23Menstrual irregularities (HP:0000858)3.29985097
24Papilledema (HP:0001085)3.27576507
25Prominent metopic ridge (HP:0005487)3.27484879
26Dysostosis multiplex (HP:0000943)3.25330810
27Hyperphosphatemia (HP:0002905)3.04926578
28Congenital sensorineural hearing impairment (HP:0008527)3.01294491
29Urinary glycosaminoglycan excretion (HP:0003541)2.92815561
30Mucopolysacchariduria (HP:0008155)2.92815561
31Vascular calcification (HP:0004934)2.88188360
32Unilateral renal agenesis (HP:0000122)2.86987799
33Progressive macrocephaly (HP:0004481)2.81321658
34Abnormality of the metopic suture (HP:0005556)2.80800654
35Hypokalemia (HP:0002900)2.79490061
36Proximal tubulopathy (HP:0000114)2.79158459
37Insulin resistance (HP:0000855)2.78446922
38Abnormality of urine glucose concentration (HP:0011016)2.76793177
39Glycosuria (HP:0003076)2.76793177
40Postural tremor (HP:0002174)2.73324024
41Ketosis (HP:0001946)2.71904655
42Increased CSF protein (HP:0002922)2.70402573
43Decreased circulating renin level (HP:0003351)2.68829444
44Abnormal albumin level (HP:0012116)2.68798647
45Hypoalbuminemia (HP:0003073)2.68798647
46EEG with generalized epileptiform discharges (HP:0011198)2.68117339
47Growth hormone excess (HP:0000845)2.68000116
48Abnormal pancreas size (HP:0012094)2.66552871
49Methylmalonic acidemia (HP:0002912)2.65444345
50Hypsarrhythmia (HP:0002521)2.64704293
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.63681966
52Abnormality of polysaccharide metabolism (HP:0011012)2.63681966
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.63681966
54Pheochromocytoma (HP:0002666)2.59584770
55Hypercortisolism (HP:0001578)2.56167845
56Abnormality of potassium homeostasis (HP:0011042)2.55872893
57Epileptiform EEG discharges (HP:0011182)2.55637273
58Acute necrotizing encephalopathy (HP:0006965)2.53953970
59Osteomalacia (HP:0002749)2.51111286
60Restlessness (HP:0000711)2.50528734
61Abnormality of the renal cortex (HP:0011035)2.49395570
62Increased circulating renin level (HP:0000848)2.47881945
63Macroorchidism (HP:0000053)2.47809684
64Cardiovascular calcification (HP:0011915)2.46500656
65Hypotension (HP:0002615)2.45773832
66Hematochezia (HP:0002573)2.44255671
67Hyperkalemia (HP:0002153)2.42561905
68Conjunctival hamartoma (HP:0100780)2.36049019
69Hyperthyroidism (HP:0000836)2.35431152
70Vacuolated lymphocytes (HP:0001922)2.34141248
71Hemiparesis (HP:0001269)2.30093848
72Abnormality of renin-angiotensin system (HP:0000847)2.29702499
73Conjugated hyperbilirubinemia (HP:0002908)2.29016766
74Mitochondrial inheritance (HP:0001427)2.24375375
75Renal cortical cysts (HP:0000803)2.24053841
76Medial flaring of the eyebrow (HP:0010747)2.23104412
77Neuroendocrine neoplasm (HP:0100634)2.22353731
78Intestinal atresia (HP:0011100)2.21231932
79Tubular atrophy (HP:0000092)2.19968931
80Urethral obstruction (HP:0000796)2.19649333
81Methylmalonic aciduria (HP:0012120)2.18569250
82Hypophosphatemia (HP:0002148)2.18329877
83Pancreatic fibrosis (HP:0100732)2.17908426
84Hypoplasia of the fovea (HP:0007750)2.17454292
85Aplasia/Hypoplasia of the fovea (HP:0008060)2.17454292
86Blue irides (HP:0000635)2.14258493
873-Methylglutaconic aciduria (HP:0003535)2.13845145
88Abnormality of the fovea (HP:0000493)2.12933944
89Congenital glaucoma (HP:0001087)2.12501489
90Gaze-evoked nystagmus (HP:0000640)2.11094099
91Generalized hyperpigmentation (HP:0007440)2.10172826
92Progressive neurologic deterioration (HP:0002344)2.09081181
93Abnormal biliary tract morphology (HP:0012440)2.06887744
94Nephronophthisis (HP:0000090)2.05961171
95Albinism (HP:0001022)2.05773437
96Hamartoma of the eye (HP:0010568)2.05739915
97Acute encephalopathy (HP:0006846)2.05613184
98Pancreatic cysts (HP:0001737)2.05556210
99Attenuation of retinal blood vessels (HP:0007843)2.04508161
100Poor suck (HP:0002033)2.04223078
101Abdominal distention (HP:0003270)2.03374042
102Renal Fanconi syndrome (HP:0001994)2.03361052
103Gastrointestinal atresia (HP:0002589)2.00899774
104Hypokinesia (HP:0002375)2.00807578
105Furrowed tongue (HP:0000221)2.00122686
106Abnormality of chloride homeostasis (HP:0011422)2.00065903
107Abnormal mitochondria in muscle tissue (HP:0008316)2.00020161
108Abdominal situs inversus (HP:0003363)1.99350624
109Abnormality of abdominal situs (HP:0011620)1.99350624
110Increased CSF lactate (HP:0002490)1.98191228
111Aqueductal stenosis (HP:0002410)1.98170849
112Episodic fever (HP:0001954)1.96043445
113Abnormality of renal resorption (HP:0011038)1.95931536
114Testicular neoplasm (HP:0010788)1.95522264
115Lipid accumulation in hepatocytes (HP:0006561)1.95189393
116Anxiety (HP:0000739)1.94328793
117Congenital stationary night blindness (HP:0007642)1.94159617
118Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92371203
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92371203
120Hyperphosphaturia (HP:0003109)1.92304925
121Abnormal sex determination (HP:0012244)1.92115447
122Sex reversal (HP:0012245)1.92115447
123Hepatoblastoma (HP:0002884)1.91420960
124Abnormality of the intrinsic pathway (HP:0010989)1.91204376
125Limb hypertonia (HP:0002509)1.90737069
126Palpitations (HP:0001962)1.90659350
127Severe visual impairment (HP:0001141)1.89790235
128Increased hepatocellular lipid droplets (HP:0006565)1.88257991
129Progressive cerebellar ataxia (HP:0002073)1.88018031
130Abnormality of vitamin B metabolism (HP:0004340)1.87681504
131Papillary thyroid carcinoma (HP:0002895)1.86737694
132Abnormal rod and cone electroretinograms (HP:0008323)1.85720752
133Abnormal drinking behavior (HP:0030082)1.85521920
134Polydipsia (HP:0001959)1.85521920
135Long toe (HP:0010511)1.85516355
136Adrenal overactivity (HP:0002717)1.83390927
137Tachypnea (HP:0002789)1.82265767
138Gout (HP:0001997)1.81789043
139Missing ribs (HP:0000921)1.81180436
140Hypoplastic labia majora (HP:0000059)1.80140499
141Abnormal autonomic nervous system physiology (HP:0012332)1.79771773
142Anteriorly placed anus (HP:0001545)1.79142023
143Exocrine pancreatic insufficiency (HP:0001738)1.78409559
144Abnormality of vitamin metabolism (HP:0100508)1.78113185
145Cortical visual impairment (HP:0100704)1.75858204
146Neoplasm of the heart (HP:0100544)1.74029424
147Skin nodule (HP:0200036)1.73459448
148Aplasia/hypoplasia of the uterus (HP:0008684)1.69211369
149Type II lissencephaly (HP:0007260)1.66392061
150Striae distensae (HP:0001065)1.65444847
151Muscular hypotonia of the trunk (HP:0008936)1.63879672
152Severe short stature (HP:0003510)1.63782488
153Enlarged penis (HP:0000040)1.62752168
154Hypoventilation (HP:0002791)1.60323765
155Hypothermia (HP:0002045)1.59827108
156Cardiomegaly (HP:0001640)1.59696914
157White forelock (HP:0002211)1.59182216
158Abnormality of the labia majora (HP:0012881)1.59168801
159Generalized aminoaciduria (HP:0002909)1.58545748
160Neoplasm of the thyroid gland (HP:0100031)1.57155271
161Enlarged kidneys (HP:0000105)1.56216422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.59840901
2MAPK157.23378930
3PIK3CG4.57926428
4INSRR3.92553573
5MST43.91804500
6TAOK33.48856686
7WNK43.46741116
8FRK3.44868510
9MAP4K23.19230460
10PHKG23.10811242
11PHKG13.10811242
12FGFR23.00058853
13GRK12.78540705
14UHMK12.76741197
15MAP2K62.41911341
16MAP3K22.31231583
17PRKD32.26280996
18HIPK22.18468856
19PASK2.07577518
20FGFR31.88580360
21TRPM71.85391566
22PINK11.65838075
23MAP3K41.61226949
24MAP3K121.59609831
25CASK1.59521775
26STK31.58948007
27MAP3K11.53532951
28WNK11.40169342
29DYRK1B1.34602932
30LMTK21.34541208
31ERN11.34412553
32STK241.34360125
33SCYL21.32769422
34CAMKK21.31634811
35EPHA31.29188127
36ACVR1B1.27966101
37PAK31.21751033
38CSNK1G11.21015292
39STK38L1.16123166
40TNK21.12926887
41PLK21.12181200
42KSR21.06039409
43BRSK21.04861067
44MKNK21.02723582
45MAP3K91.01616646
46CDC42BPA0.98435449
47CSNK1G30.97502359
48PTK60.96518672
49EPHA20.94349788
50PRKD20.93730640
51CSNK1G20.91383876
52TAOK10.90378249
53STK390.89415446
54PRKCG0.89364854
55OXSR10.86493291
56PRKCH0.84276590
57PTK2B0.83334694
58PTK20.82921159
59YES10.78878392
60NTRK10.74265276
61FER0.74195607
62TNIK0.71916671
63STK110.70931991
64FLT30.69871346
65STK40.67921822
66NTRK30.67206264
67ZAK0.64676155
68PNCK0.64251338
69EIF2AK30.63662446
70AKT30.63536644
71MAPK130.62900204
72PDGFRA0.62240536
73IRAK10.61164244
74BRD40.61042084
75STK160.58262662
76MAP2K20.52751658
77BMPR20.51600684
78IRAK30.49739772
79BRAF0.49398535
80NUAK10.49372399
81PRKAA20.48262367
82PRKG10.47168650
83CSK0.46418328
84MAPKAPK30.46257786
85CAMK2D0.46089356
86EIF2AK10.45213784
87TESK10.45077302
88MYLK0.44395025
89CAMK2A0.43696685
90MTOR0.43648711
91STK380.43518658
92RIPK10.42258198
93RET0.41145403
94PRKAA10.41075218
95JAK20.40030102
96TRIM280.39959198
97ARAF0.39914362
98TRIB30.39328158
99FGFR40.38724315
100BRSK10.38571753
101RPS6KA50.38123022
102ITK0.36188222
103PRKACB0.35983580
104DAPK10.34997953
105TLK10.34449773
106AKT20.33987925
107CSNK1D0.33594592
108LIMK10.33528715
109MET0.33451257
110PRKCQ0.31574766
111ROCK10.31495963
112PRKG20.30771005
113PRKD10.30489921
114PRKCA0.30069759
115MAP2K70.29848717
116EPHB10.29408532
117DYRK30.28978274
118CHUK0.28927500
119ERBB40.28747061
120GSK3A0.28734443
121ADRBK20.28421338
122MAP2K10.28321159
123MAP2K40.27853529
124NLK0.27503124
125GRK70.26464858
126PRKCZ0.25930916
127PLK30.25277029
128PRKCI0.24893301
129CAMK1G0.24657916
130DYRK1A0.23975034
131PRKCE0.23875845
132SGK4940.23766317
133SGK2230.23766317
134IKBKB0.23644947
135ROCK20.21902793
136CSNK1A10.21862832
137PRKDC0.20521986
138RPS6KB10.20100199
139JAK10.19906547
140SGK10.18461878
141BMPR1B0.18407628
142CAMK2B0.17762692
143SGK30.17133636
144PRKACG0.16978963
145CAMKK10.16563578
146MARK20.16316782
147DAPK20.16064259
148RPS6KA30.15683844
149BCR0.15653851
150MAPK100.15508244
151NEK90.14769041
152KSR10.14717752
153SIK10.14427952
154PRKACA0.14084645
155CDK50.13624008
156ADRBK10.13320513
157MAPKAPK20.13112574
158IGF1R0.12544125
159CSNK1A1L0.11719897
160ERBB30.11691023
161MAPK140.11468676
162PAK60.11002709

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.38117348
2Protein export_Homo sapiens_hsa030604.80047026
3* Insulin secretion_Homo sapiens_hsa049113.24780225
4Type I diabetes mellitus_Homo sapiens_hsa049403.16509222
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.94858933
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72180716
7Vitamin B6 metabolism_Homo sapiens_hsa007502.56946827
8Butanoate metabolism_Homo sapiens_hsa006502.38848990
9Type II diabetes mellitus_Homo sapiens_hsa049302.31860674
10Oxidative phosphorylation_Homo sapiens_hsa001902.31483508
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.94878627
12Vibrio cholerae infection_Homo sapiens_hsa051101.94363897
13Sulfur metabolism_Homo sapiens_hsa009201.91655670
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91452499
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80742639
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71581800
17Cocaine addiction_Homo sapiens_hsa050301.60215503
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52316403
19Circadian rhythm_Homo sapiens_hsa047101.51449540
20Lysosome_Homo sapiens_hsa041421.45858062
21Phototransduction_Homo sapiens_hsa047441.44953483
22Pancreatic secretion_Homo sapiens_hsa049721.40888645
23Prion diseases_Homo sapiens_hsa050201.37268924
24Arginine biosynthesis_Homo sapiens_hsa002201.37236267
25N-Glycan biosynthesis_Homo sapiens_hsa005101.33800513
26Amphetamine addiction_Homo sapiens_hsa050311.31127285
27Peroxisome_Homo sapiens_hsa041461.29811561
28Regulation of autophagy_Homo sapiens_hsa041401.27681311
29Folate biosynthesis_Homo sapiens_hsa007901.27125157
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26912160
31Fatty acid elongation_Homo sapiens_hsa000621.24356546
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23682862
33Parkinsons disease_Homo sapiens_hsa050121.22012111
34Propanoate metabolism_Homo sapiens_hsa006401.18547964
35Thyroid hormone synthesis_Homo sapiens_hsa049181.18283889
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13636849
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10674634
38ABC transporters_Homo sapiens_hsa020101.09770338
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07749332
40GABAergic synapse_Homo sapiens_hsa047271.07610909
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07110282
42Alzheimers disease_Homo sapiens_hsa050101.06894584
43Other glycan degradation_Homo sapiens_hsa005111.06536238
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.03536701
45Linoleic acid metabolism_Homo sapiens_hsa005911.00046354
46Circadian entrainment_Homo sapiens_hsa047130.99740602
47Renin secretion_Homo sapiens_hsa049240.99565961
48Dopaminergic synapse_Homo sapiens_hsa047280.98246414
49Estrogen signaling pathway_Homo sapiens_hsa049150.96156837
50Mineral absorption_Homo sapiens_hsa049780.96057491
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95755304
52Glutathione metabolism_Homo sapiens_hsa004800.94285915
53* Glucagon signaling pathway_Homo sapiens_hsa049220.90811659
54beta-Alanine metabolism_Homo sapiens_hsa004100.90235114
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88614572
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88002649
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87538109
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86581796
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85402753
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84008602
61Retinol metabolism_Homo sapiens_hsa008300.82999233
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82824105
63Selenocompound metabolism_Homo sapiens_hsa004500.79742482
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79224777
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78871377
66Protein digestion and absorption_Homo sapiens_hsa049740.77749600
67Cardiac muscle contraction_Homo sapiens_hsa042600.76702225
68Serotonergic synapse_Homo sapiens_hsa047260.74947897
69Fat digestion and absorption_Homo sapiens_hsa049750.74817517
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.74717768
71Metabolic pathways_Homo sapiens_hsa011000.73851018
72Cholinergic synapse_Homo sapiens_hsa047250.72791961
73cAMP signaling pathway_Homo sapiens_hsa040240.70873574
74Long-term potentiation_Homo sapiens_hsa047200.69145499
75Taste transduction_Homo sapiens_hsa047420.68025757
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65583787
77Synaptic vesicle cycle_Homo sapiens_hsa047210.65553953
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65077271
79Dorso-ventral axis formation_Homo sapiens_hsa043200.64759773
80Insulin resistance_Homo sapiens_hsa049310.64530165
81Fatty acid metabolism_Homo sapiens_hsa012120.63761649
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63580062
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62629063
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.61201109
85Chemical carcinogenesis_Homo sapiens_hsa052040.59138894
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58631513
87Huntingtons disease_Homo sapiens_hsa050160.57961752
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57893735
89Insulin signaling pathway_Homo sapiens_hsa049100.57762116
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56027377
91Caffeine metabolism_Homo sapiens_hsa002320.55284170
92Prolactin signaling pathway_Homo sapiens_hsa049170.54687735
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53913341
94Alcoholism_Homo sapiens_hsa050340.52298975
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.51648165
96Morphine addiction_Homo sapiens_hsa050320.50739555
97Ether lipid metabolism_Homo sapiens_hsa005650.50426039
98Gastric acid secretion_Homo sapiens_hsa049710.50135305
99Long-term depression_Homo sapiens_hsa047300.49037063
100Fatty acid degradation_Homo sapiens_hsa000710.48896313
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48163013
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48074227
103Inositol phosphate metabolism_Homo sapiens_hsa005620.46350497
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45557060
105Renin-angiotensin system_Homo sapiens_hsa046140.45199019
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44859328
107Melanogenesis_Homo sapiens_hsa049160.44522570
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44398413
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43831397
110Thyroid cancer_Homo sapiens_hsa052160.43345137
111Nitrogen metabolism_Homo sapiens_hsa009100.42682654
112Gap junction_Homo sapiens_hsa045400.41291893
113Bladder cancer_Homo sapiens_hsa052190.40826675
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40255164
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39722151
116Complement and coagulation cascades_Homo sapiens_hsa046100.39584087
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38633025
118mTOR signaling pathway_Homo sapiens_hsa041500.36969847
119Oxytocin signaling pathway_Homo sapiens_hsa049210.36777261
120Collecting duct acid secretion_Homo sapiens_hsa049660.36499224
121Ovarian steroidogenesis_Homo sapiens_hsa049130.35973554
122Purine metabolism_Homo sapiens_hsa002300.34851824
123Sphingolipid metabolism_Homo sapiens_hsa006000.34612578
124GnRH signaling pathway_Homo sapiens_hsa049120.33976106
125Renal cell carcinoma_Homo sapiens_hsa052110.32934130
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32335745
127Glutamatergic synapse_Homo sapiens_hsa047240.30918505
128Antigen processing and presentation_Homo sapiens_hsa046120.28330711
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.27973108
130Starch and sucrose metabolism_Homo sapiens_hsa005000.27655581
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26499727
132Lysine degradation_Homo sapiens_hsa003100.23213174
133Tryptophan metabolism_Homo sapiens_hsa003800.22556458
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22165853
135Wnt signaling pathway_Homo sapiens_hsa043100.21248423
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20717801
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.19826496
138AMPK signaling pathway_Homo sapiens_hsa041520.18556825
139Dilated cardiomyopathy_Homo sapiens_hsa054140.17731901
140Arachidonic acid metabolism_Homo sapiens_hsa005900.17238003
141Salivary secretion_Homo sapiens_hsa049700.13392763
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12013967
143Acute myeloid leukemia_Homo sapiens_hsa052210.11249793
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10348354

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