GCGR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.33272954
2epoxygenase P450 pathway (GO:0019373)8.27459081
3omega-hydroxylase P450 pathway (GO:0097267)8.26935461
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.73754467
5L-phenylalanine catabolic process (GO:0006559)7.73754467
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.38454896
7L-phenylalanine metabolic process (GO:0006558)7.38454896
8aromatic amino acid family catabolic process (GO:0009074)6.89144716
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26246462
10tryptophan catabolic process (GO:0006569)6.24360162
11indole-containing compound catabolic process (GO:0042436)6.24360162
12indolalkylamine catabolic process (GO:0046218)6.24360162
13kynurenine metabolic process (GO:0070189)6.07664472
14tryptophan metabolic process (GO:0006568)5.90430525
15bile acid biosynthetic process (GO:0006699)5.89469575
16drug metabolic process (GO:0017144)5.86913234
17glyoxylate metabolic process (GO:0046487)5.76082564
18phenylpropanoid metabolic process (GO:0009698)5.64807255
19alpha-linolenic acid metabolic process (GO:0036109)5.55246815
20urea metabolic process (GO:0019627)5.52106166
21urea cycle (GO:0000050)5.52106166
22high-density lipoprotein particle remodeling (GO:0034375)5.48274426
23negative regulation of fibrinolysis (GO:0051918)5.47799432
24regulation of plasminogen activation (GO:0010755)5.40548891
25oxidative demethylation (GO:0070989)5.39590489
26regulation of fibrinolysis (GO:0051917)5.38575232
27protein carboxylation (GO:0018214)5.36597918
28peptidyl-glutamic acid carboxylation (GO:0017187)5.36597918
29regulation of protein activation cascade (GO:2000257)5.29104070
30sulfur amino acid catabolic process (GO:0000098)5.25822607
31cysteine metabolic process (GO:0006534)5.25186204
32complement activation, alternative pathway (GO:0006957)5.23286077
33nitrogen cycle metabolic process (GO:0071941)5.08162224
34bile acid metabolic process (GO:0008206)5.06961545
35serine family amino acid catabolic process (GO:0009071)5.03168962
36aromatic amino acid family metabolic process (GO:0009072)5.02947805
37ethanol metabolic process (GO:0006067)4.91549726
38regulation of complement activation (GO:0030449)4.91310564
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88284128
40tyrosine metabolic process (GO:0006570)4.86443757
41regulation of cholesterol esterification (GO:0010872)4.79896131
42reverse cholesterol transport (GO:0043691)4.77820840
43regulation of triglyceride catabolic process (GO:0010896)4.75379386
44triglyceride homeostasis (GO:0070328)4.72819512
45acylglycerol homeostasis (GO:0055090)4.72819512
46protein-lipid complex remodeling (GO:0034368)4.68346739
47macromolecular complex remodeling (GO:0034367)4.68346739
48plasma lipoprotein particle remodeling (GO:0034369)4.68346739
49homocysteine metabolic process (GO:0050667)4.67138681
50alpha-amino acid catabolic process (GO:1901606)4.63498418
51negative regulation of hemostasis (GO:1900047)4.59928439
52negative regulation of blood coagulation (GO:0030195)4.59928439
53lysine catabolic process (GO:0006554)4.56072229
54lysine metabolic process (GO:0006553)4.56072229
55phospholipid efflux (GO:0033700)4.54212614
56negative regulation of cholesterol transport (GO:0032375)4.53603614
57negative regulation of sterol transport (GO:0032372)4.53603614
58amino-acid betaine metabolic process (GO:0006577)4.50043987
59acute-phase response (GO:0006953)4.48988105
60indolalkylamine metabolic process (GO:0006586)4.48513528
61coenzyme catabolic process (GO:0009109)4.47750118
62imidazole-containing compound metabolic process (GO:0052803)4.46732684
63cellular ketone body metabolic process (GO:0046950)4.41520389
64bile acid and bile salt transport (GO:0015721)4.33817990
65cellular biogenic amine catabolic process (GO:0042402)4.31792591
66amine catabolic process (GO:0009310)4.31792591
67regulation of humoral immune response (GO:0002920)4.30061538
68glycine metabolic process (GO:0006544)4.29643668
69glutamate metabolic process (GO:0006536)4.29409201
70plasma lipoprotein particle clearance (GO:0034381)4.28745093
71cellular amino acid catabolic process (GO:0009063)4.26271387
72cholesterol efflux (GO:0033344)4.18470515
73negative regulation of coagulation (GO:0050819)4.17204416
74negative regulation of protein activation cascade (GO:2000258)4.15864429
75negative regulation of wound healing (GO:0061045)4.15184164
76alkaloid metabolic process (GO:0009820)4.12195956
77benzene-containing compound metabolic process (GO:0042537)4.12163876
78cellular modified amino acid catabolic process (GO:0042219)4.11568345
79S-adenosylmethionine metabolic process (GO:0046500)4.10105625
80cellular glucuronidation (GO:0052695)4.08769654
81serine family amino acid metabolic process (GO:0009069)4.08615980
82positive regulation of fatty acid biosynthetic process (GO:0045723)4.04972726
83positive regulation of blood coagulation (GO:0030194)3.99933170
84positive regulation of hemostasis (GO:1900048)3.99933170
85ethanol oxidation (GO:0006069)3.96484014
86fibrinolysis (GO:0042730)3.96081728
87plasma lipoprotein particle assembly (GO:0034377)3.94750190
88dicarboxylic acid biosynthetic process (GO:0043650)3.92501721
89arginine metabolic process (GO:0006525)3.91339023
90regulation of cholesterol homeostasis (GO:2000188)3.91151216
91drug catabolic process (GO:0042737)3.91066855
92aldehyde catabolic process (GO:0046185)3.90337810
93serine family amino acid biosynthetic process (GO:0009070)3.88752355
94low-density lipoprotein particle remodeling (GO:0034374)3.87214019
95regulation of bile acid biosynthetic process (GO:0070857)3.84630856
96blood coagulation, intrinsic pathway (GO:0007597)3.83332064
97ketone body metabolic process (GO:1902224)3.81922216
98cofactor catabolic process (GO:0051187)3.78971348
99positive regulation of triglyceride lipase activity (GO:0061365)3.78645657
100positive regulation of lipoprotein lipase activity (GO:0051006)3.78645657
101complement activation, classical pathway (GO:0006958)3.74266322
102organic acid catabolic process (GO:0016054)3.73029365
103carboxylic acid catabolic process (GO:0046395)3.73029365
104very-low-density lipoprotein particle assembly (GO:0034379)3.72520051
105cholesterol homeostasis (GO:0042632)3.70274786
106protein activation cascade (GO:0072376)3.68759674
107negative regulation of lipase activity (GO:0060192)3.67862347
108complement activation (GO:0006956)3.66718666
109intestinal cholesterol absorption (GO:0030299)3.65667101
110acetyl-CoA metabolic process (GO:0006084)3.65384028
111positive regulation of coagulation (GO:0050820)3.65209814
112phospholipid homeostasis (GO:0055091)3.64753827
113positive regulation of lipid catabolic process (GO:0050996)3.64150408
114sterol homeostasis (GO:0055092)3.64147319
115cytolysis (GO:0019835)3.64030694
116uronic acid metabolic process (GO:0006063)3.62167314
117glucuronate metabolic process (GO:0019585)3.62167314
118short-chain fatty acid metabolic process (GO:0046459)3.61221138
119regulation of lipoprotein particle clearance (GO:0010984)3.59156606
120opsonization (GO:0008228)3.59058826
121plasma lipoprotein particle organization (GO:0071827)3.57058362
122NAD biosynthetic process (GO:0009435)3.54660369
123negative regulation of complement activation (GO:0045916)3.54595047
124protein-lipid complex assembly (GO:0065005)3.51861650
125acute inflammatory response (GO:0002526)3.48568885
126heme transport (GO:0015886)3.44259571
127positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.39605518
128flavonoid metabolic process (GO:0009812)3.39179160
129protein-lipid complex subunit organization (GO:0071825)3.37682105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.42881200
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19313334
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.88384654
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50464302
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.37710482
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13627713
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67370913
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.11163700
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09133357
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06582687
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8807138
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98830611
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98706076
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.61603771
15CLOCK_20551151_ChIP-Seq_293T_Human1.52532340
16GATA1_22025678_ChIP-Seq_K562_Human1.47827240
17HNF4A_19822575_ChIP-Seq_HepG2_Human1.41124491
18* HTT_18923047_ChIP-ChIP_STHdh_Human1.38865837
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31000273
20RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21873401
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20696423
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20387333
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07432352
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04090514
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96273987
26TRIM28_21343339_ChIP-Seq_HEK293_Human0.95650584
27ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93147116
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91585090
29E2F1_20622854_ChIP-Seq_HELA_Human0.91157259
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89437631
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89397430
32CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88669362
33HNFA_21074721_ChIP-Seq_CACO-2_Human0.86198211
34MYC_19829295_ChIP-Seq_ESCs_Human0.84896114
35PHF8_20622853_ChIP-Seq_HELA_Human0.84377168
36ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84242274
37RAC3_21632823_ChIP-Seq_H3396_Human0.83967589
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82574307
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81247157
40SOX2_21211035_ChIP-Seq_LN229_Human0.80739361
41AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79784772
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79438324
43GATA4_25053715_ChIP-Seq_YYC3_Human0.79347300
44RARA_24833708_ChIP-Seq_LIVER_Mouse0.78885539
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.77751753
46EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77667658
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77077939
48SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76797426
49* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75877693
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73617425
51ERA_21632823_ChIP-Seq_H3396_Human0.73472694
52KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73432648
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72997906
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72762468
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71339651
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71223704
57RARB_24833708_ChIP-Seq_LIVER_Mouse0.70846025
58ELF1_20517297_ChIP-Seq_JURKAT_Human0.69936789
59CTCF_20526341_ChIP-Seq_ESCs_Human0.69478401
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69211973
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68697066
62GATA6_21074721_ChIP-Seq_CACO-2_Human0.68391362
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67884443
64NFYA_21822215_ChIP-Seq_K562_Human0.67205978
65SA1_27219007_Chip-Seq_Bcells_Human0.67023911
66SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66859709
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66058517
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.66021959
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65852131
70CTCF_27219007_Chip-Seq_Bcells_Human0.63852260
71SMC4_20622854_ChIP-Seq_HELA_Human0.62948400
72RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62481309
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62442494
74* LXR_22292898_ChIP-Seq_THP-1_Human0.62319693
75NANOG_20526341_ChIP-Seq_ESCs_Human0.61936337
76BCL6_27268052_Chip-Seq_Bcells_Human0.61870093
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61352550
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.61063127
79SOX2_20726797_ChIP-Seq_SW620_Human0.60512008
80NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.60441909
81P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.60433544
82P300_27268052_Chip-Seq_Bcells_Human0.60422041
83SPI1_20517297_ChIP-Seq_HL60_Human0.60091534
84ETV1_20927104_ChIP-Seq_GIST48_Human0.60036314
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.59531101
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.59531101
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59372839
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.59071121
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.59071121
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58991457
91CBX2_22325352_ChIP-Seq_293T-Rex_Human0.58861013
92ZNF263_19887448_ChIP-Seq_K562_Human0.58378513
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57792465
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.57540428
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57276346
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56931262
97* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.56930114
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.55914384
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55807990
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55780811
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.55636197
102FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55494159
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.55221016
104CEBPB_22108803_ChIP-Seq_LS180_Human0.53794033
105AR_20517297_ChIP-Seq_VCAP_Human0.52777658
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52618563
107* MYC_19915707_ChIP-ChIP_AK7_Human0.49891919
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.48556515
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.48164637
110P53_21459846_ChIP-Seq_SAOS-2_Human0.47530598
111CBP_21632823_ChIP-Seq_H3396_Human0.47145681
112EGR1_19032775_ChIP-ChIP_M12_Human0.47041942
113* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46797614
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46215423
115GATA1_19941826_ChIP-Seq_K562_Human0.44415273
116STAT1_17558387_ChIP-Seq_HELA_Human0.44047571
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.43731439
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.42546555
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.42516585
120GATA6_25053715_ChIP-Seq_YYC3_Human0.42275228
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.42273564
122* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42135936
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.42029400
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41905024
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.41234411
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.41003457
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.40973750
128TAF2_19829295_ChIP-Seq_ESCs_Human0.40924606
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40019719
130BCAT_22108803_ChIP-Seq_LS180_Human0.38998368
131ERG_20517297_ChIP-Seq_VCAP_Human0.37636521
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37614360
133GATA2_19941826_ChIP-Seq_K562_Human0.37400415
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37335711
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36968959
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.36419309
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35817141
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.35739444
139LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35616839
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35481942
141OCT4_20526341_ChIP-Seq_ESCs_Human0.35329833
142BCOR_27268052_Chip-Seq_Bcells_Human0.34483851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32364370
2MP0005360_urolithiasis7.35879133
3MP0005085_abnormal_gallbladder_physiolo6.46615457
4MP0005365_abnormal_bile_salt6.17544950
5MP0008875_abnormal_xenobiotic_pharmacok5.10705288
6MP0003806_abnormal_nucleotide_metabolis4.19018986
7MP0003252_abnormal_bile_duct4.02097965
8* MP0010329_abnormal_lipoprotein_level3.46506388
9MP0009840_abnormal_foam_cell3.30721352
10MP0005083_abnormal_biliary_tract3.10510403
11MP0003195_calcinosis3.10275094
12MP0005332_abnormal_amino_acid2.76209963
13MP0001666_abnormal_nutrient_absorption2.62900157
14MP0003191_abnormal_cellular_cholesterol2.33897467
15MP0000609_abnormal_liver_physiology2.19239817
16* MP0002118_abnormal_lipid_homeostasis2.13380212
17MP0004019_abnormal_vitamin_homeostasis2.13096537
18MP0002138_abnormal_hepatobiliary_system1.97537163
19MP0003868_abnormal_feces_composition1.96662140
20MP0005319_abnormal_enzyme/_coenzyme1.80857394
21MP0001764_abnormal_homeostasis1.64675443
22MP0005584_abnormal_enzyme/coenzyme_acti1.54099815
23MP0009697_abnormal_copulation1.48376973
24MP0005451_abnormal_body_composition1.42780845
25MP0009643_abnormal_urine_homeostasis1.31346583
26MP0003011_delayed_dark_adaptation1.28569093
27MP0003186_abnormal_redox_activity1.20124509
28MP0000598_abnormal_liver_morphology1.17898501
29MP0003656_abnormal_erythrocyte_physiolo1.17069817
30MP0002132_abnormal_respiratory_system1.16482970
31MP0005647_abnormal_sex_gland1.12999825
32MP0003705_abnormal_hypodermis_morpholog1.07915779
33MP0003879_abnormal_hair_cell1.04046867
34MP0000604_amyloidosis1.02847053
35MP0009764_decreased_sensitivity_to1.02441915
36MP0010368_abnormal_lymphatic_system1.01216279
37MP0009763_increased_sensitivity_to0.99700682
38MP0005636_abnormal_mineral_homeostasis0.98568363
39MP0002254_reproductive_system_inflammat0.96069597
40MP0005220_abnormal_exocrine_pancreas0.95807695
41MP0005408_hypopigmentation0.90864755
42* MP0009642_abnormal_blood_homeostasis0.89944925
43* MP0002078_abnormal_glucose_homeostasis0.89534891
44MP0008469_abnormal_protein_level0.86532599
45MP0006036_abnormal_mitochondrial_physio0.85741665
46MP0005084_abnormal_gallbladder_morpholo0.85026867
47MP0002876_abnormal_thyroid_physiology0.84951781
48MP0005670_abnormal_white_adipose0.82566388
49MP0001986_abnormal_taste_sensitivity0.82148752
50MP0005187_abnormal_penis_morphology0.80991280
51MP0005376_homeostasis/metabolism_phenot0.77065427
52MP0009765_abnormal_xenobiotic_induced0.76023179
53MP0005535_abnormal_body_temperature0.73425413
54MP0002282_abnormal_trachea_morphology0.71119662
55MP0003283_abnormal_digestive_organ0.71016127
56MP0005377_hearing/vestibular/ear_phenot0.70295372
57MP0003878_abnormal_ear_physiology0.70295372
58MP0001661_extended_life_span0.70009111
59* MP0005334_abnormal_fat_pad0.66286144
60MP0002249_abnormal_larynx_morphology0.65492453
61MP0004130_abnormal_muscle_cell0.64977661
62MP0001756_abnormal_urination0.64719727
63MP0005266_abnormal_metabolism0.63869384
64MP0000639_abnormal_adrenal_gland0.62194221
65MP0003329_amyloid_beta_deposits0.61617329
66MP0003690_abnormal_glial_cell0.61526215
67* MP0002971_abnormal_brown_adipose0.60856719
68MP0002928_abnormal_bile_duct0.60738513
69MP0005448_abnormal_energy_balance0.59851783
70MP0009053_abnormal_anal_canal0.58752418
71MP0002909_abnormal_adrenal_gland0.57060948
72MP0002837_dystrophic_cardiac_calcinosis0.55986267
73MP0006035_abnormal_mitochondrial_morpho0.54004146
74MP0001915_intracranial_hemorrhage0.53995535
75MP0005464_abnormal_platelet_physiology0.53228133
76MP0004883_abnormal_blood_vessel0.52509489
77MP0002090_abnormal_vision0.50930172
78MP0004510_myositis0.50290762
79MP0009785_altered_susceptibility_to0.49412458
80MP0005395_other_phenotype0.48523632
81* MP0003953_abnormal_hormone_level0.48058992
82MP0005164_abnormal_response_to0.48033077
83MP0003724_increased_susceptibility_to0.47657094
84MP0000579_abnormal_nail_morphology0.46708462
85MP0002136_abnormal_kidney_physiology0.46262135
86MP0003638_abnormal_response/metabolism_0.45180368
87MP0002822_catalepsy0.44149184
88MP0003718_maternal_effect0.43941413
89MP0005379_endocrine/exocrine_gland_phen0.42153016
90MP0008874_decreased_physiological_sensi0.41988452
91MP0004043_abnormal_pH_regulation0.41902903
92MP0008873_increased_physiological_sensi0.41755979
93MP0004782_abnormal_surfactant_physiolog0.41506947
94MP0003436_decreased_susceptibility_to0.41243025
95MP0005248_abnormal_Harderian_gland0.40657671
96MP0009672_abnormal_birth_weight0.39053432
97MP0003075_altered_response_to0.39015322
98* MP0001944_abnormal_pancreas_morphology0.37936268
99MP0005666_abnormal_adipose_tissue0.37457079
100MP0004264_abnormal_extraembryonic_tissu0.37252489
101MP0005166_decreased_susceptibility_to0.35140494
102MP0000230_abnormal_systemic_arterial0.34479055
103MP0002970_abnormal_white_adipose0.33803519
104MP0004381_abnormal_hair_follicle0.33436548
105MP0001243_abnormal_dermal_layer0.32690052
106MP0002168_other_aberrant_phenotype0.32607149
107MP0009115_abnormal_fat_cell0.31870315
108MP0009384_cardiac_valve_regurgitation0.30612623
109MP0006082_CNS_inflammation0.30492239
110MP0005397_hematopoietic_system_phenotyp0.29696989
111MP0001545_abnormal_hematopoietic_system0.29696989
112MP0001502_abnormal_circadian_rhythm0.29379739
113MP0008872_abnormal_physiological_respon0.29322513
114MP0000249_abnormal_blood_vessel0.29137571
115MP0005646_abnormal_pituitary_gland0.28903407
116MP0005058_abnormal_lysosome_morphology0.27750101
117MP0002796_impaired_skin_barrier0.26971711
118MP0002693_abnormal_pancreas_physiology0.26740911
119MP0005023_abnormal_wound_healing0.26589437
120MP0001881_abnormal_mammary_gland0.26253248
121MP0002332_abnormal_exercise_endurance0.26128901
122MP0001845_abnormal_inflammatory_respons0.26097718
123MP0002295_abnormal_pulmonary_circulatio0.25536013
124MP0005551_abnormal_eye_electrophysiolog0.24112028
125MP0003959_abnormal_lean_body0.23977032
126MP0010386_abnormal_urinary_bladder0.23323368

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.61171530
2Intrahepatic cholestasis (HP:0001406)7.19878206
3Deep venous thrombosis (HP:0002625)7.18454299
4Prolonged partial thromboplastin time (HP:0003645)6.63209380
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60498039
6Hypobetalipoproteinemia (HP:0003563)6.27943705
7Xanthomatosis (HP:0000991)6.24035998
8Hyperlipoproteinemia (HP:0010980)5.50901902
9Complement deficiency (HP:0004431)5.24247842
10Joint hemorrhage (HP:0005261)4.78555271
11Hypolipoproteinemia (HP:0010981)4.67730154
12Abnormality of the common coagulation pathway (HP:0010990)4.55803097
13Epidermoid cyst (HP:0200040)4.48605762
14Hyperammonemia (HP:0001987)4.46200813
15Ketosis (HP:0001946)4.38884739
16Hyperglycinemia (HP:0002154)4.38640003
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26462528
18Hypoglycemic coma (HP:0001325)4.23025867
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.18647337
20Abnormality of methionine metabolism (HP:0010901)4.18306529
21Hypoalphalipoproteinemia (HP:0003233)4.12085470
22Fat malabsorption (HP:0002630)4.05698474
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.03508487
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.02295523
25Abnormality of the intrinsic pathway (HP:0010989)3.90812768
26Hyperglycinuria (HP:0003108)3.89040783
27Abnormality of serine family amino acid metabolism (HP:0010894)3.86221302
28Abnormality of glycine metabolism (HP:0010895)3.86221302
29Abnormality of complement system (HP:0005339)3.81080496
30Conjugated hyperbilirubinemia (HP:0002908)3.79397793
31Abnormality of pyrimidine metabolism (HP:0004353)3.65985483
32Hypercholesterolemia (HP:0003124)3.51708631
33Nephritis (HP:0000123)3.42407401
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38160243
35Ketoacidosis (HP:0001993)3.31265062
36Abnormality of fatty-acid metabolism (HP:0004359)3.30209929
37Hyperbilirubinemia (HP:0002904)3.28851522
38Spontaneous abortion (HP:0005268)3.15462748
39Delayed CNS myelination (HP:0002188)3.06817517
40Abnormality of nucleobase metabolism (HP:0010932)3.05242745
41Steatorrhea (HP:0002570)3.03746728
42Myocardial infarction (HP:0001658)3.01396750
43Abnormality of serum amino acid levels (HP:0003112)2.97659519
44Hypoglycemic seizures (HP:0002173)2.97621469
45Hypochromic microcytic anemia (HP:0004840)2.94212074
46Hepatocellular carcinoma (HP:0001402)2.92679584
47Neonatal hypoglycemia (HP:0001998)2.86762878
48Skin nodule (HP:0200036)2.83505271
49Metabolic acidosis (HP:0001942)2.76188720
50Abnormality of purine metabolism (HP:0004352)2.74871376
51Systemic lupus erythematosus (HP:0002725)2.66924078
52Gout (HP:0001997)2.63181495
53Fair hair (HP:0002286)2.57982066
54Vascular calcification (HP:0004934)2.57876942
55Dicarboxylic aciduria (HP:0003215)2.57155562
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57155562
57Lethargy (HP:0001254)2.56107248
58Hyperinsulinemic hypoglycemia (HP:0000825)2.55507621
59Purpura (HP:0000979)2.54388520
60Mitral stenosis (HP:0001718)2.52148142
61Abnormal gallbladder morphology (HP:0012437)2.45668254
62Acanthocytosis (HP:0001927)2.42702434
63Late onset (HP:0003584)2.41653491
64Irritability (HP:0000737)2.41014649
65Cholelithiasis (HP:0001081)2.36160592
66Glomerulonephritis (HP:0000099)2.35152731
67Spastic diplegia (HP:0001264)2.34769208
68Amyloidosis (HP:0011034)2.34606603
69Cerebral edema (HP:0002181)2.33370214
70Malnutrition (HP:0004395)2.31459144
71Neonatal onset (HP:0003623)2.29530420
72Arthropathy (HP:0003040)2.28003722
73Cardiovascular calcification (HP:0011915)2.27564853
74Pulmonary embolism (HP:0002204)2.26672517
75Gingival bleeding (HP:0000225)2.23949801
76Cholecystitis (HP:0001082)2.23408946
77Abnormal gallbladder physiology (HP:0012438)2.23408946
78Enlarged kidneys (HP:0000105)2.21077898
79Recurrent gram-negative bacterial infections (HP:0005420)2.20256839
80Hyperphosphaturia (HP:0003109)2.19101204
81Menorrhagia (HP:0000132)2.18523048
82Generalized aminoaciduria (HP:0002909)2.18341424
83Brushfield spots (HP:0001088)2.17409941
84Pancreatitis (HP:0001733)2.13266843
85Abnormality of the Achilles tendon (HP:0005109)2.11550718
86Sensorimotor neuropathy (HP:0007141)2.11074079
87Esophageal varix (HP:0002040)2.09486971
88Opisthotonus (HP:0002179)2.08984946
89Thrombophlebitis (HP:0004418)2.07886283
90Vomiting (HP:0002013)2.05970902
91Symptomatic seizures (HP:0011145)2.05886017
92Hemorrhage of the eye (HP:0011885)2.05497694
93Abnormality of urine glucose concentration (HP:0011016)2.01841546
94Glycosuria (HP:0003076)2.01841546
95Retinal atrophy (HP:0001105)2.00093473
96Hyperglycemia (HP:0003074)1.99621684
97Osteomalacia (HP:0002749)1.98534052
98Abnormality of the gallbladder (HP:0005264)1.98301121
99Rickets (HP:0002748)1.95958939
100Alkalosis (HP:0001948)1.92766731
101Poikilocytosis (HP:0004447)1.92309079
102Reduced antithrombin III activity (HP:0001976)1.91398448
103Hypophosphatemic rickets (HP:0004912)1.91283338
104Renal cortical cysts (HP:0000803)1.90738809
105Abnormality of transition element cation homeostasis (HP:0011030)1.88985931
106Abnormality of iron homeostasis (HP:0011031)1.88978181
107Abnormal enzyme/coenzyme activity (HP:0012379)1.86203292
108Hydroxyprolinuria (HP:0003080)1.85942172
109Abnormality of proline metabolism (HP:0010907)1.85942172
110Atrioventricular block (HP:0001678)1.83882669
111Abnormal cartilage morphology (HP:0002763)1.82413893
112Hypothermia (HP:0002045)1.81519241
113Elevated hepatic transaminases (HP:0002910)1.81505628
114Abnormal biliary tract physiology (HP:0012439)1.80463498
115Bile duct proliferation (HP:0001408)1.80463498
116Gangrene (HP:0100758)1.80307015
117Increased serum ferritin (HP:0003281)1.78637522
118Abnormal urine phosphate concentration (HP:0012599)1.78208662
119Elevated alkaline phosphatase (HP:0003155)1.78078326
120Acute hepatic failure (HP:0006554)1.77235871
121Joint swelling (HP:0001386)1.76968259
122Generalized hypopigmentation of hair (HP:0011358)1.75033001
123Status epilepticus (HP:0002133)1.74892077
124Abnormality of vitamin metabolism (HP:0100508)1.70348115
125Abnormality of alkaline phosphatase activity (HP:0004379)1.65064742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.71646623
2ERN15.08692232
3SIK14.62292588
4FGFR44.61600186
5INSRR3.96893152
6TAOK33.40705099
7ERBB42.92050247
8PASK2.53653587
9NTRK32.24807992
10FLT32.13351659
11WNK32.12581903
12MAP2K42.08532253
13WNK42.01922262
14MAPK151.98168970
15PDK21.91059536
16PKN21.85602127
17MAPK111.82970918
18TRIB31.81297863
19MST1R1.79825560
20TNK21.78054288
21PIK3CG1.66613546
22PTK61.65483248
23LATS11.63443268
24TYK21.54636364
25NLK1.51678286
26STK161.51597115
27MUSK1.47963438
28DAPK21.45374028
29FRK1.25699480
30ABL21.25304240
31JAK21.25089915
32NEK91.15801965
33KDR1.14433915
34HIPK21.14350943
35FGFR21.10322171
36MAP3K71.05995633
37PINK11.05905125
38PRKAA21.05661804
39ERBB21.02097875
40EPHA30.98449185
41JAK10.97992763
42MAP3K100.95039988
43PRKACA0.92983125
44PRKG10.91793012
45ADRBK20.91633359
46TBK10.91065863
47MET0.90276695
48PRKCZ0.88296728
49DYRK1B0.87902988
50MAP3K140.85241962
51TRPM70.84832212
52EPHB10.84277556
53MAP2K30.83138593
54MAP4K20.82969946
55MAPK40.82947710
56GRK60.81903421
57IRAK30.80882111
58CSNK1D0.80631631
59MAP3K30.80595428
60STK38L0.78257464
61CAMK1D0.76348333
62PRKACG0.74868698
63PTK20.74062801
64CSK0.72466809
65STK380.71669888
66CDK60.70480763
67PRKAA10.70060411
68CAMK2G0.69939058
69TIE10.69557408
70GSK3A0.69467418
71MAP3K110.66988878
72MAP3K40.66506514
73OXSR10.65603578
74CHUK0.61850067
75MAPK120.59352048
76PRKCE0.58184037
77FER0.57080853
78SGK30.56352703
79PDPK10.54846107
80IKBKE0.53618857
81SGK10.53484837
82MAP2K60.52034117
83STK390.50594375
84ACVR1B0.49396444
85RIPK10.49329164
86MAP3K10.49277675
87MAPK70.49195952
88IKBKB0.48932691
89KIT0.48049166
90FGFR30.47973990
91PHKG10.47817034
92PHKG20.47817034
93PRKCB0.46863106
94CSNK1G10.45348869
95PRKACB0.45307429
96BLK0.45294810
97PRKCQ0.43366948
98MTOR0.43346440
99TGFBR20.43299144
100CAMKK20.42997124
101SGK20.42893162
102MAP3K20.42164657
103IGF1R0.42032888
104ICK0.41851838
105CSNK1A10.40891082
106CAMK2D0.39240875
107RPS6KA30.38835686
108IRAK10.38356459
109MAP2K10.38263558
110PKN10.37786368
111PRKCG0.37033336
112GRK10.36998374
113PAK30.36572078
114CAMK40.36034326
115CSF1R0.35759948
116CSNK2A10.35532060
117MAPKAPK30.34729516
118RET0.34706642
119CSNK2A20.34686661
120SGK4940.34006444
121SGK2230.34006444
122CAMK1G0.32710723
123MAP2K20.32587219
124CDK40.31873609
125PDGFRA0.30527430
126EPHA40.29463688
127EGFR0.28463691
128PDK10.27598377
129MAP3K50.27041247
130CSNK1G20.26811542
131PIK3CA0.26066694
132MAP3K130.25754546
133CSNK1A1L0.25487110
134MAP3K60.25241541
135PRKCA0.25188286
136CSNK1G30.22929097
137IRAK20.22765788
138AKT30.21877506
139TAOK20.21605466

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52659428
2Nitrogen metabolism_Homo sapiens_hsa009103.44470982
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30282940
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29067356
5Arginine biosynthesis_Homo sapiens_hsa002203.01232639
6Tryptophan metabolism_Homo sapiens_hsa003802.77282502
7Complement and coagulation cascades_Homo sapiens_hsa046102.77262207
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67577952
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61327201
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53289204
11Fatty acid degradation_Homo sapiens_hsa000712.51131415
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41111429
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22956692
14Butanoate metabolism_Homo sapiens_hsa006502.19932071
15Peroxisome_Homo sapiens_hsa041462.10708095
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10330254
17Histidine metabolism_Homo sapiens_hsa003401.96483041
18Chemical carcinogenesis_Homo sapiens_hsa052041.89441056
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.87372608
20Propanoate metabolism_Homo sapiens_hsa006401.86784648
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85602127
22PPAR signaling pathway_Homo sapiens_hsa033201.85109953
23Fatty acid metabolism_Homo sapiens_hsa012121.80779902
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77112149
25Staphylococcus aureus infection_Homo sapiens_hsa051501.74602569
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72484602
27Selenocompound metabolism_Homo sapiens_hsa004501.72008333
28beta-Alanine metabolism_Homo sapiens_hsa004101.69413534
29Retinol metabolism_Homo sapiens_hsa008301.66672192
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64720768
31Caffeine metabolism_Homo sapiens_hsa002321.63886845
32Phenylalanine metabolism_Homo sapiens_hsa003601.57689281
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57427963
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52400623
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.50520775
36Bile secretion_Homo sapiens_hsa049761.49389226
37Tyrosine metabolism_Homo sapiens_hsa003501.47776893
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47412972
39Sulfur metabolism_Homo sapiens_hsa009201.47401289
40Pyruvate metabolism_Homo sapiens_hsa006201.36147353
41Fatty acid elongation_Homo sapiens_hsa000621.31533870
42Folate biosynthesis_Homo sapiens_hsa007901.31420429
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.29948279
44Starch and sucrose metabolism_Homo sapiens_hsa005001.28563032
45ABC transporters_Homo sapiens_hsa020101.24827847
46Steroid biosynthesis_Homo sapiens_hsa001001.16851909
47Fat digestion and absorption_Homo sapiens_hsa049751.15874183
48Biosynthesis of amino acids_Homo sapiens_hsa012301.14973116
49Carbon metabolism_Homo sapiens_hsa012001.07480599
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03295243
51Arginine and proline metabolism_Homo sapiens_hsa003300.98493208
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.96767085
53Vitamin B6 metabolism_Homo sapiens_hsa007500.95563562
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94942344
55Sulfur relay system_Homo sapiens_hsa041220.93402175
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85937974
57Lysine degradation_Homo sapiens_hsa003100.85588385
58Vitamin digestion and absorption_Homo sapiens_hsa049770.84929282
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84332869
60One carbon pool by folate_Homo sapiens_hsa006700.76943426
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68042541
62Glycerolipid metabolism_Homo sapiens_hsa005610.65944732
63Glutathione metabolism_Homo sapiens_hsa004800.62077479
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53267768
65Pentose phosphate pathway_Homo sapiens_hsa000300.49790299
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49272956
67Fatty acid biosynthesis_Homo sapiens_hsa000610.48910921
68Metabolic pathways_Homo sapiens_hsa011000.46493855
69Prion diseases_Homo sapiens_hsa050200.39419563
70Pertussis_Homo sapiens_hsa051330.33882800
71Galactose metabolism_Homo sapiens_hsa000520.30477089
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29738369
73Insulin resistance_Homo sapiens_hsa049310.29253675
74Fructose and mannose metabolism_Homo sapiens_hsa000510.24929783
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.23244998
76Linoleic acid metabolism_Homo sapiens_hsa005910.23213138
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.18138618
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16184525
79Other glycan degradation_Homo sapiens_hsa005110.13597371
80Mineral absorption_Homo sapiens_hsa049780.11478534
81* Glucagon signaling pathway_Homo sapiens_hsa049220.08684251
82AMPK signaling pathway_Homo sapiens_hsa041520.04601778
83Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2125569
84Protein export_Homo sapiens_hsa03060-0.2104618
85Bladder cancer_Homo sapiens_hsa05219-0.2060621
86Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2022570
87African trypanosomiasis_Homo sapiens_hsa05143-0.1874467
88Lysosome_Homo sapiens_hsa04142-0.1829101
89Hepatitis C_Homo sapiens_hsa05160-0.1744994
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.1704791
91Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1697374
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1681235
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1547580
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1536419
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1322592
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1295069
97Circadian rhythm_Homo sapiens_hsa04710-0.1263166
98Insulin secretion_Homo sapiens_hsa04911-0.1224639
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1008502
100Regulation of autophagy_Homo sapiens_hsa04140-0.0880731
101Renin-angiotensin system_Homo sapiens_hsa04614-0.0803509
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0709733
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.0694765
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0667609
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0663239
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0445115
107Amoebiasis_Homo sapiens_hsa05146-0.0374718
108Serotonergic synapse_Homo sapiens_hsa04726-0.0340726
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0221584
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0122475

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