GCHFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.47774078
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.47774078
3L-phenylalanine metabolic process (GO:0006558)7.18664527
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18664527
5aromatic amino acid family catabolic process (GO:0009074)6.63471091
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.38183223
7tryptophan catabolic process (GO:0006569)5.87496557
8indole-containing compound catabolic process (GO:0042436)5.87496557
9indolalkylamine catabolic process (GO:0046218)5.87496557
10glyoxylate metabolic process (GO:0046487)5.83192197
11kynurenine metabolic process (GO:0070189)5.76046382
12bile acid biosynthetic process (GO:0006699)5.72404764
13high-density lipoprotein particle remodeling (GO:0034375)5.66338080
14sulfur amino acid catabolic process (GO:0000098)5.60035966
15tryptophan metabolic process (GO:0006568)5.53868870
16negative regulation of fibrinolysis (GO:0051918)5.48635805
17urea cycle (GO:0000050)5.45138981
18urea metabolic process (GO:0019627)5.45138981
19regulation of fibrinolysis (GO:0051917)5.25594575
20cysteine metabolic process (GO:0006534)5.24065113
21alpha-linolenic acid metabolic process (GO:0036109)5.21071308
22peptidyl-glutamic acid carboxylation (GO:0017187)5.07117863
23protein carboxylation (GO:0018214)5.07117863
24serine family amino acid catabolic process (GO:0009071)5.05808189
25nitrogen cycle metabolic process (GO:0071941)5.03925535
26aromatic amino acid family metabolic process (GO:0009072)5.03776358
27regulation of cholesterol esterification (GO:0010872)4.97623636
28regulation of triglyceride catabolic process (GO:0010896)4.95923278
29complement activation, alternative pathway (GO:0006957)4.92495281
30reverse cholesterol transport (GO:0043691)4.91717683
31regulation of protein activation cascade (GO:2000257)4.90702711
32bile acid metabolic process (GO:0008206)4.86468481
33bile acid and bile salt transport (GO:0015721)4.84216408
34protein-lipid complex remodeling (GO:0034368)4.80049390
35macromolecular complex remodeling (GO:0034367)4.80049390
36plasma lipoprotein particle remodeling (GO:0034369)4.80049390
37tyrosine metabolic process (GO:0006570)4.73260666
38indolalkylamine metabolic process (GO:0006586)4.72825702
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70284213
40phospholipid efflux (GO:0033700)4.66300584
41negative regulation of sterol transport (GO:0032372)4.58655559
42negative regulation of cholesterol transport (GO:0032375)4.58655559
43acylglycerol homeostasis (GO:0055090)4.58207501
44triglyceride homeostasis (GO:0070328)4.58207501
45cellular glucuronidation (GO:0052695)4.57888992
46amino-acid betaine metabolic process (GO:0006577)4.57428720
47homocysteine metabolic process (GO:0050667)4.56618211
48regulation of complement activation (GO:0030449)4.56386357
49cellular ketone body metabolic process (GO:0046950)4.56380332
50alpha-amino acid catabolic process (GO:1901606)4.55198625
51lysine metabolic process (GO:0006553)4.46058189
52lysine catabolic process (GO:0006554)4.46058189
53plasma lipoprotein particle clearance (GO:0034381)4.40833875
54coenzyme catabolic process (GO:0009109)4.36397479
55imidazole-containing compound metabolic process (GO:0052803)4.31505840
56aldehyde catabolic process (GO:0046185)4.24022692
57cellular amino acid catabolic process (GO:0009063)4.23509357
58glycine metabolic process (GO:0006544)4.20484948
59NADH metabolic process (GO:0006734)4.17401090
60glucuronate metabolic process (GO:0019585)4.17120093
61uronic acid metabolic process (GO:0006063)4.17120093
62cholesterol efflux (GO:0033344)4.15074187
63arginine metabolic process (GO:0006525)4.10693097
64glutamate metabolic process (GO:0006536)4.10210136
65amine catabolic process (GO:0009310)4.08298538
66cellular biogenic amine catabolic process (GO:0042402)4.08298538
67ethanol oxidation (GO:0006069)4.07642267
68serine family amino acid metabolic process (GO:0009069)4.06402581
69benzene-containing compound metabolic process (GO:0042537)4.05415325
70drug catabolic process (GO:0042737)4.05149435
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04743278
72cellular modified amino acid catabolic process (GO:0042219)4.01364226
73plasma lipoprotein particle assembly (GO:0034377)3.95323179
74ketone body metabolic process (GO:1902224)3.94509159
75positive regulation of triglyceride lipase activity (GO:0061365)3.91781420
76positive regulation of lipoprotein lipase activity (GO:0051006)3.91781420
77fibrinolysis (GO:0042730)3.90948298
78negative regulation of lipase activity (GO:0060192)3.90343400
79serine family amino acid biosynthetic process (GO:0009070)3.86395734
80low-density lipoprotein particle remodeling (GO:0034374)3.83008782
81fructose metabolic process (GO:0006000)3.82057210
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81992470
83positive regulation of lipid catabolic process (GO:0050996)3.80734220
84dicarboxylic acid biosynthetic process (GO:0043650)3.76987402
85cofactor catabolic process (GO:0051187)3.75159066
86cholesterol homeostasis (GO:0042632)3.74179330
87organic acid catabolic process (GO:0016054)3.74058508
88carboxylic acid catabolic process (GO:0046395)3.74058508
89short-chain fatty acid metabolic process (GO:0046459)3.73918560
90blood coagulation, intrinsic pathway (GO:0007597)3.73652141
91sterol homeostasis (GO:0055092)3.68050150
92phospholipid homeostasis (GO:0055091)3.67181389
93acetyl-CoA metabolic process (GO:0006084)3.65776393
94flavonoid metabolic process (GO:0009812)3.62421441
95exogenous drug catabolic process (GO:0042738)3.61684223
96plasma lipoprotein particle organization (GO:0071827)3.59653776
97alkaloid metabolic process (GO:0009820)3.59255960
98very-low-density lipoprotein particle assembly (GO:0034379)3.57805888
99response to nitrosative stress (GO:0051409)3.57250884
100acute-phase response (GO:0006953)3.54430155
101NAD biosynthetic process (GO:0009435)3.54197261
102protein-lipid complex assembly (GO:0065005)3.53128968
103lipoprotein metabolic process (GO:0042157)3.50079478
104nicotinamide nucleotide biosynthetic process (GO:0019359)3.48697151
105energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47715116
106ATP synthesis coupled proton transport (GO:0015986)3.47715116
107glycosphingolipid catabolic process (GO:0046479)3.38106462
108epoxygenase P450 pathway (GO:0019373)3.35491573
109oligosaccharide catabolic process (GO:0009313)3.35297779
110respiratory electron transport chain (GO:0022904)3.34524917
111positive regulation of fatty acid biosynthetic process (GO:0045723)3.34501004
112fat-soluble vitamin biosynthetic process (GO:0042362)3.33841674
113electron transport chain (GO:0022900)3.25937110
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15691917
115glycolipid catabolic process (GO:0019377)3.13330071
116pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00419142
117deoxyribonucleotide catabolic process (GO:0009264)2.95718127
118deoxyribose phosphate catabolic process (GO:0046386)2.90954373
119oxidative phosphorylation (GO:0006119)2.90808563
120cytochrome complex assembly (GO:0017004)2.90195417
121vitamin biosynthetic process (GO:0009110)2.89614862
122protein complex biogenesis (GO:0070271)2.87930559
123L-ascorbic acid metabolic process (GO:0019852)2.86798608
124xenobiotic catabolic process (GO:0042178)2.86250019
125protein-lipid complex subunit organization (GO:0071825)2.85145988
126respiratory chain complex IV assembly (GO:0008535)2.84765546
127purine deoxyribonucleotide catabolic process (GO:0009155)2.83140753
128regulation of superoxide anion generation (GO:0032928)2.81116156
129chaperone-mediated protein transport (GO:0072321)2.79479174
130ceramide catabolic process (GO:0046514)2.76418142
131oxaloacetate metabolic process (GO:0006107)2.76041004
132regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.74585174
133GDP-mannose metabolic process (GO:0019673)2.73081111
134regulation of mitochondrial translation (GO:0070129)2.72749312
135regulation of lipoprotein particle clearance (GO:0010984)2.70881613
136aggressive behavior (GO:0002118)2.70400392
137autophagic vacuole fusion (GO:0000046)2.69607020
138mitochondrial respiratory chain complex assembly (GO:0033108)2.68879737
139base-excision repair, AP site formation (GO:0006285)2.66887030
140pentose metabolic process (GO:0019321)2.64477186
141mitochondrial calcium ion transport (GO:0006851)2.63180941
142drug metabolic process (GO:0017144)2.62528296
143angiotensin maturation (GO:0002003)2.53961635
144glutathione derivative biosynthetic process (GO:1901687)2.53745881
145glutathione derivative metabolic process (GO:1901685)2.53745881
146regulation of cholesterol storage (GO:0010885)2.53654766
147heme metabolic process (GO:0042168)2.52613360
148regulation of cholesterol transport (GO:0032374)2.51986471
149regulation of sterol transport (GO:0032371)2.51986471
150sphingolipid catabolic process (GO:0030149)2.51399690
151glutathione metabolic process (GO:0006749)2.50981760
152regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50851443
153aerobic respiration (GO:0009060)2.47368752
154water-soluble vitamin biosynthetic process (GO:0042364)2.45388049
155negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44985523
156protein maturation by protein folding (GO:0022417)2.44700633
157heme transport (GO:0015886)2.44031620
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.43279896
159NADH dehydrogenase complex assembly (GO:0010257)2.43279896
160mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43279896
161hydrogen ion transmembrane transport (GO:1902600)2.41623295
162immunoglobulin mediated immune response (GO:0016064)2.40371094
163pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.39286282
164glutamine family amino acid biosynthetic process (GO:0009084)2.38844587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.24506748
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.04664257
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.74773124
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.33028028
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.36046148
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.12512636
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04578404
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.82339780
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.71309377
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51334226
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43528527
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13804175
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97010949
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87193826
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55179548
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.55069854
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.38428839
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31667726
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.27616957
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25654709
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22443365
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21420305
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20443377
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.04483661
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.03014341
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.00390900
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8788146
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98116119
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93962730
30* SRF_21415370_ChIP-Seq_HL-1_Mouse1.90866900
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88515345
32CLOCK_20551151_ChIP-Seq_293T_Human1.75433683
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73378029
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73047886
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72598947
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68630877
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66062749
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60537123
39GABP_19822575_ChIP-Seq_HepG2_Human1.56489815
40VDR_23849224_ChIP-Seq_CD4+_Human1.56434090
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55484892
42DCP1A_22483619_ChIP-Seq_HELA_Human1.53786163
43FOXP3_21729870_ChIP-Seq_TREG_Human1.49738477
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49274312
45E2F7_22180533_ChIP-Seq_HELA_Human1.48460797
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47092611
47BCL6_27268052_Chip-Seq_Bcells_Human1.46999166
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.46806123
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.45850991
50VDR_21846776_ChIP-Seq_THP-1_Human1.41901456
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.41230774
52* HTT_18923047_ChIP-ChIP_STHdh_Human1.39982486
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39917404
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39560062
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39248474
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37462179
57* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36495996
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36258805
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.34870194
60BCOR_27268052_Chip-Seq_Bcells_Human1.33017945
61XRN2_22483619_ChIP-Seq_HELA_Human1.31054399
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29472674
63GATA1_22025678_ChIP-Seq_K562_Human1.28556666
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27944775
65SPI1_23547873_ChIP-Seq_NB4_Human1.24019132
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22587529
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22200571
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21897315
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19052577
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18038786
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17920274
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17707792
73P68_20966046_ChIP-Seq_HELA_Human1.14846901
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14703722
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14147735
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12234395
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.10091830
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08885761
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07836285
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.07475410
81TTF2_22483619_ChIP-Seq_HELA_Human1.07395718
82TFEB_21752829_ChIP-Seq_HELA_Human1.07132053
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06969491
84E2F1_20622854_ChIP-Seq_HELA_Human1.04895791
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03564480
86* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02524475
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01438030
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00438640
89P300_27268052_Chip-Seq_Bcells_Human1.00091571
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99145267
91* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98955656
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98728485
93* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97983924
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97720791
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97085064
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97041232
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96468645
98SA1_27219007_Chip-Seq_Bcells_Human0.96450478
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95420661
100PHF8_20622854_ChIP-Seq_HELA_Human0.95062268
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94634008
102STAT1_20625510_ChIP-Seq_HELA_Human0.94593101
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94439523
104* FOXP1_21924763_ChIP-Seq_HESCs_Human0.94039995
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91537792
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87731044
107GATA4_25053715_ChIP-Seq_YYC3_Human0.87532597
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84387981
109ZNF263_19887448_ChIP-Seq_K562_Human0.84228132
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.82493159
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81820590
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78991581
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78821637
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78674068
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.76395182
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74897382
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74547331
118RARA_24833708_ChIP-Seq_LIVER_Mouse0.73636778
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73286573
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73286573
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71935483
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71176892
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69694998
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66610770
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65654003
126LXR_22292898_ChIP-Seq_THP-1_Human0.65286005
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64842613
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64620110
129SOX2_20726797_ChIP-Seq_SW620_Human0.61310423
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59448829
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.59433186
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59429225
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.59129525
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.58398885
135IRF8_22096565_ChIP-ChIP_GC-B_Human0.57869351
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57669074
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57124169
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.56309557
139MYC_19915707_ChIP-ChIP_AK7_Human0.54591129
140CEBPB_22108803_ChIP-Seq_LS180_Human0.53893883
141* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53343225
142AR_20517297_ChIP-Seq_VCAP_Human0.53037414
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52361880
144EGR1_19032775_ChIP-ChIP_M12_Human0.51562183
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50904056
146FOXA1_25552417_ChIP-Seq_VCAP_Human0.50843108
147P53_21459846_ChIP-Seq_SAOS-2_Human0.47904973
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47736470
149GATA6_25053715_ChIP-Seq_YYC3_Human0.46703478
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.46450040
151TAF2_19829295_ChIP-Seq_ESCs_Human0.45380131
152* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44798899
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44678154
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.44240290
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.42984456
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.42766795
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.42054197
158STAT1_17558387_ChIP-Seq_HELA_Human0.41894841
159CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.41392117
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.41298999
161CBP_21632823_ChIP-Seq_H3396_Human0.41137369
162* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41071883
163BCAT_22108803_ChIP-Seq_LS180_Human0.40612741
164MYC_27129775_Chip-Seq_CORNEA_Mouse0.39446699
165FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.39302739
166CTCF_27219007_Chip-Seq_Bcells_Human0.39107958
167NCOR_22424771_ChIP-Seq_293T_Human0.38700841
168PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38661767
169GATA2_19941826_ChIP-Seq_K562_Human0.38618541
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.38106540
171CSB_26484114_Chip-Seq_FIBROBLAST_Human0.38017128
172GATA1_19941826_ChIP-Seq_K562_Human0.37578097
173RACK7_27058665_Chip-Seq_MCF-7_Human0.37570284
174NANOG_20526341_ChIP-Seq_ESCs_Human0.37563116
175OCT4_18692474_ChIP-Seq_MEFs_Mouse0.37374861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17036508
2MP0005360_urolithiasis7.64493307
3MP0005085_abnormal_gallbladder_physiolo6.24239625
4MP0005365_abnormal_bile_salt5.99365112
5MP0008875_abnormal_xenobiotic_pharmacok5.33499596
6MP0003806_abnormal_nucleotide_metabolis4.32677442
7MP0003252_abnormal_bile_duct3.79453999
8MP0010329_abnormal_lipoprotein_level3.59874538
9MP0009840_abnormal_foam_cell3.22628316
10MP0005083_abnormal_biliary_tract2.95722748
11MP0005332_abnormal_amino_acid2.86506002
12MP0003195_calcinosis2.80133917
13MP0005058_abnormal_lysosome_morphology2.75434558
14MP0001666_abnormal_nutrient_absorption2.51498490
15MP0003191_abnormal_cellular_cholesterol2.39528036
16MP0004019_abnormal_vitamin_homeostasis2.12048878
17MP0002118_abnormal_lipid_homeostasis2.09899638
18MP0000609_abnormal_liver_physiology2.07628278
19MP0002138_abnormal_hepatobiliary_system1.95468428
20MP0005319_abnormal_enzyme/_coenzyme1.87350955
21MP0003868_abnormal_feces_composition1.76672709
22MP0009333_abnormal_splenocyte_physiolog1.74159482
23MP0002148_abnormal_hypersensitivity_rea1.73316493
24MP0001764_abnormal_homeostasis1.72366325
25MP0009697_abnormal_copulation1.62369368
26MP0005584_abnormal_enzyme/coenzyme_acti1.57930003
27MP0005671_abnormal_response_to1.54313964
28MP0001835_abnormal_antigen_presentation1.51178291
29MP0005451_abnormal_body_composition1.47438396
30MP0010234_abnormal_vibrissa_follicle1.47427014
31MP0003186_abnormal_redox_activity1.42305651
32MP0010386_abnormal_urinary_bladder1.40152876
33MP0009785_altered_susceptibility_to1.39834265
34MP0001986_abnormal_taste_sensitivity1.39281690
35MP0003011_delayed_dark_adaptation1.36047999
36MP0009643_abnormal_urine_homeostasis1.35633804
37MP0003705_abnormal_hypodermis_morpholog1.35259329
38MP0005025_abnormal_response_to1.30477541
39MP0002419_abnormal_innate_immunity1.29749979
40MP0004147_increased_porphyrin_level1.26710944
41MP0001545_abnormal_hematopoietic_system1.24436498
42MP0005397_hematopoietic_system_phenotyp1.24436498
43MP0000604_amyloidosis1.19257342
44MP0005645_abnormal_hypothalamus_physiol1.16904789
45MP0000598_abnormal_liver_morphology1.15168842
46MP0002452_abnormal_antigen_presenting1.14762287
47MP0003656_abnormal_erythrocyte_physiolo1.13772512
48MP0005000_abnormal_immune_tolerance1.13480635
49MP0001845_abnormal_inflammatory_respons1.12951295
50MP0005387_immune_system_phenotype1.05648290
51MP0001790_abnormal_immune_system1.05648290
52MP0002723_abnormal_immune_serum1.03960931
53MP0003436_decreased_susceptibility_to1.03408645
54MP0010368_abnormal_lymphatic_system1.03177813
55MP0010155_abnormal_intestine_physiology1.02821764
56MP0005410_abnormal_fertilization1.02664520
57MP0005647_abnormal_sex_gland1.02085669
58MP0000343_altered_response_to1.01175930
59MP0003693_abnormal_embryo_hatching0.97947400
60MP0001800_abnormal_humoral_immune0.97900150
61MP0005636_abnormal_mineral_homeostasis0.97881083
62MP0005084_abnormal_gallbladder_morpholo0.96227423
63MP0000685_abnormal_immune_system0.95855650
64MP0009764_decreased_sensitivity_to0.94956414
65MP0005670_abnormal_white_adipose0.94762503
66MP0003879_abnormal_hair_cell0.94760674
67MP0002090_abnormal_vision0.94567869
68MP0002420_abnormal_adaptive_immunity0.94277107
69MP0001819_abnormal_immune_cell0.94047955
70MP0009278_abnormal_bone_marrow0.93930378
71MP0006036_abnormal_mitochondrial_physio0.92454584
72MP0009763_increased_sensitivity_to0.92258688
73MP0002876_abnormal_thyroid_physiology0.90851516
74MP0009642_abnormal_blood_homeostasis0.89903864
75MP0003172_abnormal_lysosome_physiology0.88021215
76MP0000490_abnormal_crypts_of0.87598746
77MP0005376_homeostasis/metabolism_phenot0.85926343
78MP0003303_peritoneal_inflammation0.84638107
79MP0008469_abnormal_protein_level0.83331447
80MP0005408_hypopigmentation0.83171283
81MP0003786_premature_aging0.81870875
82MP0000465_gastrointestinal_hemorrhage0.80621967
83MP0000689_abnormal_spleen_morphology0.79674285
84MP0005535_abnormal_body_temperature0.79665550
85MP0004742_abnormal_vestibular_system0.79419717
86MP0009053_abnormal_anal_canal0.78906221
87MP0001727_abnormal_embryo_implantation0.78444684
88MP0009046_muscle_twitch0.77741863
89MP0002254_reproductive_system_inflammat0.77174891
90MP0001984_abnormal_olfaction0.76869380
91MP0002078_abnormal_glucose_homeostasis0.76617757
92MP0002971_abnormal_brown_adipose0.76606509
93MP0005379_endocrine/exocrine_gland_phen0.75884184
94MP0000358_abnormal_cell_content/0.75579398
95MP0005075_abnormal_melanosome_morpholog0.74384078
96MP0003866_abnormal_defecation0.73401231
97MP0005266_abnormal_metabolism0.73129190
98MP0002837_dystrophic_cardiac_calcinosis0.71401843
99MP0002277_abnormal_respiratory_mucosa0.70538920
100MP0001873_stomach_inflammation0.70319702
101MP0008260_abnormal_autophagy0.69793989
102MP0003329_amyloid_beta_deposits0.68977875
103MP0000716_abnormal_immune_system0.68273599
104MP0001756_abnormal_urination0.68253830
105MP0009765_abnormal_xenobiotic_induced0.65997720
106MP0005334_abnormal_fat_pad0.64478321
107MP0004130_abnormal_muscle_cell0.64380709
108MP0006035_abnormal_mitochondrial_morpho0.59316541
109MP0005220_abnormal_exocrine_pancreas0.58700955
110MP0000639_abnormal_adrenal_gland0.57221367
111MP0003690_abnormal_glial_cell0.53126686
112MP0005448_abnormal_energy_balance0.51548879
113MP0002136_abnormal_kidney_physiology0.50152508
114MP0003953_abnormal_hormone_level0.46861560
115MP0005395_other_phenotype0.46836690
116MP0008873_increased_physiological_sensi0.44554113
117MP0003638_abnormal_response/metabolism_0.44209389
118MP0002822_catalepsy0.43989807
119MP0004782_abnormal_surfactant_physiolog0.43708462
120MP0008874_decreased_physiological_sensi0.43618053
121MP0000230_abnormal_systemic_arterial0.43237979
122MP0004883_abnormal_blood_vessel0.43060350
123MP0005666_abnormal_adipose_tissue0.42588633
124MP0002796_impaired_skin_barrier0.42060563
125MP0001661_extended_life_span0.40828073
126MP0003718_maternal_effect0.40338859
127MP0005464_abnormal_platelet_physiology0.39608071
128MP0005248_abnormal_Harderian_gland0.38324461
129MP0008872_abnormal_physiological_respon0.38158582
130MP0000249_abnormal_blood_vessel0.36508702
131MP0003075_altered_response_to0.36294876
132MP0009672_abnormal_birth_weight0.36023469
133MP0003724_increased_susceptibility_to0.35096874
134MP0002132_abnormal_respiratory_system0.35002766
135MP0002928_abnormal_bile_duct0.34301557
136MP0005166_decreased_susceptibility_to0.33736396
137MP0001243_abnormal_dermal_layer0.32923524
138MP0009115_abnormal_fat_cell0.32594165
139MP0002970_abnormal_white_adipose0.32305271
140MP0002168_other_aberrant_phenotype0.32251095
141MP0005167_abnormal_blood-brain_barrier0.31617263
142MP0005164_abnormal_response_to0.31271398
143MP0005330_cardiomyopathy0.31200545
144MP0004043_abnormal_pH_regulation0.27565435
145MP0009379_abnormal_foot_pigmentation0.26908598
146MP0006082_CNS_inflammation0.26584346
147MP0006276_abnormal_autonomic_nervous0.26570789
148MP0002135_abnormal_kidney_morphology0.25728039
149MP0001853_heart_inflammation0.25464377
150MP0001881_abnormal_mammary_gland0.24647549

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.63970440
2Deep venous thrombosis (HP:0002625)7.21643282
3Intrahepatic cholestasis (HP:0001406)6.88981086
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.47424291
5Hypobetalipoproteinemia (HP:0003563)6.27439539
6Prolonged partial thromboplastin time (HP:0003645)6.20364957
7Xanthomatosis (HP:0000991)6.19133534
8Hyperlipoproteinemia (HP:0010980)5.60725147
9Complement deficiency (HP:0004431)4.86693498
10Hypolipoproteinemia (HP:0010981)4.76991417
11Hyperammonemia (HP:0001987)4.57561392
12Joint hemorrhage (HP:0005261)4.54415191
13Ketosis (HP:0001946)4.34866508
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34602788
15Hyperglycinemia (HP:0002154)4.30216469
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.26763866
17Hypoalphalipoproteinemia (HP:0003233)4.26009336
18Abnormality of liposaccharide metabolism (HP:0010968)4.21254248
19Abnormality of glycosphingolipid metabolism (HP:0004343)4.21254248
20Abnormality of glycolipid metabolism (HP:0010969)4.21254248
21Abnormality of methionine metabolism (HP:0010901)4.20148304
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.18848975
23Epidermoid cyst (HP:0200040)4.17030541
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15858230
25Abnormality of the common coagulation pathway (HP:0010990)4.09231374
26Hyperglycinuria (HP:0003108)4.07050806
27Abnormality of glycine metabolism (HP:0010895)3.96952936
28Abnormality of serine family amino acid metabolism (HP:0010894)3.96952936
29Hypoglycemic coma (HP:0001325)3.92865030
30Vacuolated lymphocytes (HP:0001922)3.89822868
31Fat malabsorption (HP:0002630)3.88249631
32Abnormal mitochondria in muscle tissue (HP:0008316)3.84344072
33Acute necrotizing encephalopathy (HP:0006965)3.77153261
34Mitochondrial inheritance (HP:0001427)3.68977586
35Abnormality of pyrimidine metabolism (HP:0004353)3.67591188
36Acute encephalopathy (HP:0006846)3.66123052
37Abnormality of fatty-acid metabolism (HP:0004359)3.63326305
38Abnormality of complement system (HP:0005339)3.56068195
39Hypercholesterolemia (HP:0003124)3.54080372
40Abnormality of the intrinsic pathway (HP:0010989)3.51604822
41Hepatocellular necrosis (HP:0001404)3.44101661
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41106971
43Nausea (HP:0002018)3.40757680
44Hepatic necrosis (HP:0002605)3.39109271
45Increased intramyocellular lipid droplets (HP:0012240)3.34474449
46Increased CSF lactate (HP:0002490)3.31431212
47Increased muscle lipid content (HP:0009058)3.29783688
48Hyperbilirubinemia (HP:0002904)3.24859641
49Conjugated hyperbilirubinemia (HP:0002908)3.19996030
50Ketoacidosis (HP:0001993)3.16999666
51Delayed CNS myelination (HP:0002188)3.11476253
52Lipid accumulation in hepatocytes (HP:0006561)3.03063142
53Renal Fanconi syndrome (HP:0001994)3.02949499
54Spontaneous abortion (HP:0005268)3.02947253
55Abnormality of nucleobase metabolism (HP:0010932)3.02194180
56Progressive macrocephaly (HP:0004481)3.01587504
57Abnormality of serum amino acid levels (HP:0003112)2.97429240
58Hepatocellular carcinoma (HP:0001402)2.94874719
59Increased hepatocellular lipid droplets (HP:0006565)2.94786559
60Steatorrhea (HP:0002570)2.93257979
61Metabolic acidosis (HP:0001942)2.84397106
62Lethargy (HP:0001254)2.81810576
63Dicarboxylic aciduria (HP:0003215)2.80055433
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80055433
65Cerebral edema (HP:0002181)2.78515968
66Myocardial infarction (HP:0001658)2.72926281
67Abnormality of purine metabolism (HP:0004352)2.69495675
68Increased cerebral lipofuscin (HP:0011813)2.68499413
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67623792
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67623792
71Skin nodule (HP:0200036)2.66771736
72Abnormality of macrophages (HP:0004311)2.62527191
73Gout (HP:0001997)2.60910513
74Hypochromic microcytic anemia (HP:0004840)2.58945509
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55243832
76Lactic acidosis (HP:0003128)2.55155021
77Petechiae (HP:0000967)2.51371497
78Reduced antithrombin III activity (HP:0001976)2.51341483
79Systemic lupus erythematosus (HP:0002725)2.49144821
80Vascular calcification (HP:0004934)2.49123047
81Irritability (HP:0000737)2.48708207
82Neonatal onset (HP:0003623)2.47891775
83Malnutrition (HP:0004395)2.44240618
84Respiratory failure (HP:0002878)2.44125885
85Glomerulonephritis (HP:0000099)2.41254183
86Retinal atrophy (HP:0001105)2.36036076
87Abnormal gallbladder morphology (HP:0012437)2.34325461
88Mitral stenosis (HP:0001718)2.33207816
89Methylmalonic aciduria (HP:0012120)2.32827240
90Cholecystitis (HP:0001082)2.31871544
91Abnormal gallbladder physiology (HP:0012438)2.31871544
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31825830
93Generalized aminoaciduria (HP:0002909)2.31179948
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.30105053
95Cholelithiasis (HP:0001081)2.29943556
96Amyloidosis (HP:0011034)2.29671791
97Spastic diplegia (HP:0001264)2.29498025
98Purpura (HP:0000979)2.28836298
99Multiple enchondromatosis (HP:0005701)2.28527547
100Hypoglycemic seizures (HP:0002173)2.27919264
101Increased serum ferritin (HP:0003281)2.26250000
102Vomiting (HP:0002013)2.26175926
103Esophageal varix (HP:0002040)2.23799970
104Sensorimotor neuropathy (HP:0007141)2.23425623
105Cardiovascular calcification (HP:0011915)2.22685338
106Increased serum lactate (HP:0002151)2.21628923
107Brushfield spots (HP:0001088)2.18817076
108Enlarged kidneys (HP:0000105)2.18261606
109Late onset (HP:0003584)2.16350012
110Pancreatitis (HP:0001733)2.15876935
111Cerebral palsy (HP:0100021)2.13659812
112Acanthocytosis (HP:0001927)2.12854786
113Exertional dyspnea (HP:0002875)2.11896016
114Chronic obstructive pulmonary disease (HP:0006510)2.09615403
115Obstructive lung disease (HP:0006536)2.09615403
116CNS demyelination (HP:0007305)2.09507150
117Hyperphosphaturia (HP:0003109)2.08717047
118Exercise intolerance (HP:0003546)2.07634350
119Loss of speech (HP:0002371)2.07243350
120Menorrhagia (HP:0000132)2.06950688
121Type I transferrin isoform profile (HP:0003642)2.05370855
122Thrombophlebitis (HP:0004418)2.04617227
123Progressive neurologic deterioration (HP:0002344)2.03743545
124Recurrent abscess formation (HP:0002722)2.01928035
125Gingival bleeding (HP:0000225)2.01783363
126Alkalosis (HP:0001948)2.01003019
127Recurrent gram-negative bacterial infections (HP:0005420)1.97514260
128Eczematoid dermatitis (HP:0000976)1.97155758
129Respiratory difficulties (HP:0002880)1.97118925
130Opisthotonus (HP:0002179)1.96763443
131Proximal tubulopathy (HP:0000114)1.95738641
132Abnormal cartilage morphology (HP:0002763)1.95723676
133Abnormality of proline metabolism (HP:0010907)1.94686344
134Hydroxyprolinuria (HP:0003080)1.94686344
135Abnormality of urine glucose concentration (HP:0011016)1.93422759
136Glycosuria (HP:0003076)1.93422759
137Hepatosplenomegaly (HP:0001433)1.93142998
138Rickets (HP:0002748)1.92521096
139Abnormality of the gallbladder (HP:0005264)1.91733520
1403-Methylglutaconic aciduria (HP:0003535)1.90647584
141Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90541843
142Increased serum pyruvate (HP:0003542)1.90170454
143Hypophosphatemic rickets (HP:0004912)1.89710362
144Emotional lability (HP:0000712)1.88585330
145Prolonged neonatal jaundice (HP:0006579)1.88452342
146Hyperinsulinemic hypoglycemia (HP:0000825)1.88434602
147Renal cortical cysts (HP:0000803)1.88392616
148Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87796620
149Hemorrhage of the eye (HP:0011885)1.84845367
150Ragged-red muscle fibers (HP:0003200)1.84282404
151Dysphonia (HP:0001618)1.82632129
152Dysostosis multiplex (HP:0000943)1.81888936
153Poikilocytosis (HP:0004447)1.81223016
154Status epilepticus (HP:0002133)1.80395695
155Hyperuricemia (HP:0002149)1.77572660
156Increased purine levels (HP:0004368)1.77572660
157Abnormality of iron homeostasis (HP:0011031)1.77511284
158Abnormality of transition element cation homeostasis (HP:0011030)1.77357470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.59130907
2SIK14.41659846
3MAP3K124.08547440
4FGFR44.08224268
5ERN14.03798143
6TESK23.46994941
7INSRR2.66903023
8PIM22.49510661
9MAP4K12.48945259
10PIK3CA2.44935796
11ERBB42.36671791
12VRK22.36169963
13PKN22.34893066
14ARAF2.28778514
15PDK22.28108762
16STK162.27587953
17MAP2K42.21459110
18TESK12.17711190
19TAOK32.05893630
20SCYL22.01921156
21MST1R2.01481291
22ACVR1B1.94461891
23RIPK11.91407265
24TRIB31.90216824
25ZAK1.83655584
26FRK1.74976781
27TXK1.74144774
28ABL21.70365266
29PIK3CG1.68580154
30KDR1.64257450
31MST41.56781484
32NME11.54148611
33TLK11.53500433
34MAP2K31.53399190
35MAP3K31.53080738
36MAPK111.49711750
37FLT31.46648799
38BUB11.40697317
39GRK61.39622131
40TIE11.35379700
41MAP3K111.29371361
42IRAK31.29068535
43PTK61.28365913
44TAOK21.27755515
45GRK51.27170269
46DAPK21.26187556
47MAPK151.25882489
48MAP3K141.25824177
49MAP4K21.20925116
50TYK21.17166838
51GRK71.10723634
52MYLK1.10602878
53MAPK41.10411956
54DAPK11.08699885
55PINK11.07389121
56MUSK1.05011731
57LATS11.04751415
58IKBKB1.03572083
59BRAF1.01595702
60CDK191.00174920
61PRKCZ0.94545914
62PBK0.92826684
63TBK10.92138604
64BLK0.91201732
65PRKAA20.90944392
66RPS6KA50.88397919
67MAP3K70.88357407
68CAMK2G0.88318986
69NEK90.87712971
70STK38L0.87131468
71PIM10.86029847
72CSNK1G10.85718574
73MAP2K60.85304806
74FES0.84912623
75VRK10.84912052
76JAK20.84070147
77PTK20.82136229
78MAP2K20.81635176
79ILK0.79800221
80CSNK1A1L0.78589001
81PRKACG0.76467698
82MAPK120.75814770
83NUAK10.75646662
84GSK3A0.75427572
85DYRK1B0.74231987
86EPHB20.72092954
87SYK0.71008397
88CDC70.70543203
89ERBB20.70122791
90LATS20.68898828
91EIF2AK10.68572057
92CSNK1G30.67985613
93PAK40.67705965
94LRRK20.67586964
95LYN0.66902377
96EIF2AK30.66003519
97LMTK20.62211361
98LIMK10.62187650
99SGK30.61856760
100TTK0.61717743
101KIT0.61669263
102JAK10.60551281
103PRKCI0.60200134
104CSNK1G20.57930828
105AURKA0.57837670
106MAP2K10.57777643
107TGFBR20.57624274
108CSNK2A10.57352207
109FGFR20.56218991
110ITK0.55815771
111PDK10.55443743
112STK100.55388021
113PRKCQ0.55265838
114MET0.55045729
115PRKCG0.54666246
116CDK60.53380978
117NEK10.53189143
118GRK10.51801144
119PRKAA10.50855437
120SMG10.50507418
121BTK0.49964471
122MATK0.49749675
123ADRBK20.49254619
124RIPK40.48064762
125CSNK2A20.46772937
126JAK30.46715818
127SGK4940.46655249
128SGK2230.46655249
129PAK30.46646519
130OBSCN0.46290354
131LCK0.45736827
132EPHB10.45055031
133EPHA20.45043244
134PDPK10.44859063
135SGK20.44522080
136TEC0.43056093
137CSK0.42689219
138MAP3K50.42618663
139TAOK10.42614561
140MAPK70.41963522
141PRKCD0.41597829
142PRKCA0.38971941
143DAPK30.38536922
144MAP3K100.38327392
145TNK20.38105688
146CAMKK20.38031808
147IKBKE0.37662224
148MAP3K80.37393388
149IGF1R0.33843896
150CAMK2D0.30790011
151MAP3K20.30045842
152NME20.30027745
153EPHA30.29114274
154PRKACA0.26961430
155CAMK2A0.24684097
156RET0.24459699
157CAMK1D0.23192414
158CSF1R0.22913045
159MAP3K10.22789511
160PRKG20.21935873
161CSNK1E0.21702359
162EGFR0.21545629
163MAPK30.19041748
164PRKACB0.19038016

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30344660
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39483933
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24442207
4Nitrogen metabolism_Homo sapiens_hsa009103.11062511
5Arginine biosynthesis_Homo sapiens_hsa002202.98298467
6Tryptophan metabolism_Homo sapiens_hsa003802.79185324
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61552388
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58221753
9Complement and coagulation cascades_Homo sapiens_hsa046102.57972641
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50176749
11Fatty acid degradation_Homo sapiens_hsa000712.46410187
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39578005
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38642559
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28776175
15Butanoate metabolism_Homo sapiens_hsa006502.23044105
16Proteasome_Homo sapiens_hsa030502.07976962
17Peroxisome_Homo sapiens_hsa041462.07397331
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06512367
19Chemical carcinogenesis_Homo sapiens_hsa052042.05119759
20Histidine metabolism_Homo sapiens_hsa003402.04058078
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.96798581
22Propanoate metabolism_Homo sapiens_hsa006401.96763363
23PPAR signaling pathway_Homo sapiens_hsa033201.85746128
24Other glycan degradation_Homo sapiens_hsa005111.85666522
25Phenylalanine metabolism_Homo sapiens_hsa003601.84801747
26Ribosome_Homo sapiens_hsa030101.84254498
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83648263
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.83543428
29Fatty acid metabolism_Homo sapiens_hsa012121.76599668
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74147709
31beta-Alanine metabolism_Homo sapiens_hsa004101.73567135
32Sulfur metabolism_Homo sapiens_hsa009201.71578237
33Caffeine metabolism_Homo sapiens_hsa002321.68697751
34Retinol metabolism_Homo sapiens_hsa008301.67758250
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64071845
36Tyrosine metabolism_Homo sapiens_hsa003501.60593887
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59180850
38Staphylococcus aureus infection_Homo sapiens_hsa051501.54628045
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54421026
40Bile secretion_Homo sapiens_hsa049761.53392211
41Selenocompound metabolism_Homo sapiens_hsa004501.47177724
42Pyruvate metabolism_Homo sapiens_hsa006201.38908781
43Huntingtons disease_Homo sapiens_hsa050161.38230874
44Asthma_Homo sapiens_hsa053101.36484500
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.34668805
46Fatty acid elongation_Homo sapiens_hsa000621.33004685
47Starch and sucrose metabolism_Homo sapiens_hsa005001.31976651
48Lysosome_Homo sapiens_hsa041421.31848203
49Folate biosynthesis_Homo sapiens_hsa007901.28619275
50Sulfur relay system_Homo sapiens_hsa041221.20236244
51Biosynthesis of amino acids_Homo sapiens_hsa012301.19082238
52Steroid biosynthesis_Homo sapiens_hsa001001.18395362
53DNA replication_Homo sapiens_hsa030301.18107795
54Fat digestion and absorption_Homo sapiens_hsa049751.15635292
55Carbon metabolism_Homo sapiens_hsa012001.15348789
56Base excision repair_Homo sapiens_hsa034101.06018947
57ABC transporters_Homo sapiens_hsa020101.03656243
58Mismatch repair_Homo sapiens_hsa034301.02670972
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01502499
60Allograft rejection_Homo sapiens_hsa053301.00392244
61Arginine and proline metabolism_Homo sapiens_hsa003301.00081232
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95847177
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93449209
64RNA polymerase_Homo sapiens_hsa030200.93407163
65Pyrimidine metabolism_Homo sapiens_hsa002400.93251726
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.93241587
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.92061135
68Autoimmune thyroid disease_Homo sapiens_hsa053200.89801854
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89112811
70Mineral absorption_Homo sapiens_hsa049780.88300654
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.88050799
72Antigen processing and presentation_Homo sapiens_hsa046120.86178628
73Rheumatoid arthritis_Homo sapiens_hsa053230.85800347
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85536207
75Graft-versus-host disease_Homo sapiens_hsa053320.85259150
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83724074
77Vitamin digestion and absorption_Homo sapiens_hsa049770.80686154
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80541155
79Vitamin B6 metabolism_Homo sapiens_hsa007500.79878664
80Glutathione metabolism_Homo sapiens_hsa004800.78649510
81Collecting duct acid secretion_Homo sapiens_hsa049660.73135290
82One carbon pool by folate_Homo sapiens_hsa006700.73093659
83Type I diabetes mellitus_Homo sapiens_hsa049400.71095211
84Glycerolipid metabolism_Homo sapiens_hsa005610.67722774
85Lysine degradation_Homo sapiens_hsa003100.66602634
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61267724
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59955729
88Primary immunodeficiency_Homo sapiens_hsa053400.57133670
89Pentose phosphate pathway_Homo sapiens_hsa000300.56313292
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54577033
91Sphingolipid metabolism_Homo sapiens_hsa006000.53730370
92Metabolic pathways_Homo sapiens_hsa011000.52066048
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51481095
94Homologous recombination_Homo sapiens_hsa034400.46765090
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46645114
96Purine metabolism_Homo sapiens_hsa002300.46354737
97Fatty acid biosynthesis_Homo sapiens_hsa000610.41130628
98Galactose metabolism_Homo sapiens_hsa000520.38248133
99Prion diseases_Homo sapiens_hsa050200.32715564
100Fructose and mannose metabolism_Homo sapiens_hsa000510.31243964
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23933404
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20793052
103Linoleic acid metabolism_Homo sapiens_hsa005910.20661316
104Insulin resistance_Homo sapiens_hsa049310.19037729
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18763611
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.17070325
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.11465899
108Glucagon signaling pathway_Homo sapiens_hsa049220.07869154
109Amoebiasis_Homo sapiens_hsa05146-0.2441387
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2383654
111Bladder cancer_Homo sapiens_hsa05219-0.2368580
112Regulation of autophagy_Homo sapiens_hsa04140-0.2203140
113Renin-angiotensin system_Homo sapiens_hsa04614-0.1948904
114Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1913849
115Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1879727
116Hepatitis C_Homo sapiens_hsa05160-0.1835452
117African trypanosomiasis_Homo sapiens_hsa05143-0.1558695
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1515969
119Alzheimers disease_Homo sapiens_hsa05010-0.1249801
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1192559
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1106662
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1087400
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0990660
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0940677
125Parkinsons disease_Homo sapiens_hsa05012-0.0370110
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0271745
127AMPK signaling pathway_Homo sapiens_hsa04152-0.0145676
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0050033
129Oxidative phosphorylation_Homo sapiens_hsa00190-0.0040345

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