GCLC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.28420827
2L-phenylalanine catabolic process (GO:0006559)7.28420827
3primary alcohol catabolic process (GO:0034310)7.12572103
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97202710
5L-phenylalanine metabolic process (GO:0006558)6.97202710
6polyketide metabolic process (GO:0030638)6.69022205
7doxorubicin metabolic process (GO:0044598)6.69022205
8daunorubicin metabolic process (GO:0044597)6.69022205
9aromatic amino acid family catabolic process (GO:0009074)6.61237727
10axonemal dynein complex assembly (GO:0070286)6.12135392
11indole-containing compound catabolic process (GO:0042436)6.04453207
12indolalkylamine catabolic process (GO:0046218)6.04453207
13tryptophan catabolic process (GO:0006569)6.04453207
14kynurenine metabolic process (GO:0070189)5.94930055
15aminoglycoside antibiotic metabolic process (GO:0030647)5.88339040
16* cysteine metabolic process (GO:0006534)5.81809467
17bile acid biosynthetic process (GO:0006699)5.71513640
18glyoxylate metabolic process (GO:0046487)5.71332143
19tryptophan metabolic process (GO:0006568)5.67313641
20alpha-linolenic acid metabolic process (GO:0036109)5.58694031
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.45724817
22sulfur amino acid catabolic process (GO:0000098)5.32253384
23urea metabolic process (GO:0019627)5.30933756
24urea cycle (GO:0000050)5.30933756
25lysine catabolic process (GO:0006554)5.20189715
26lysine metabolic process (GO:0006553)5.20189715
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.11789349
28ethanol metabolic process (GO:0006067)5.09238643
29negative regulation of fibrinolysis (GO:0051918)5.08851323
30protein carboxylation (GO:0018214)5.03034740
31peptidyl-glutamic acid carboxylation (GO:0017187)5.03034740
32complement activation, alternative pathway (GO:0006957)5.00607747
33serine family amino acid catabolic process (GO:0009071)4.97099263
34regulation of protein activation cascade (GO:2000257)4.94138190
35iron ion import (GO:0097286)4.91391711
36homocysteine metabolic process (GO:0050667)4.89097073
37bile acid metabolic process (GO:0008206)4.88313400
38nitrogen cycle metabolic process (GO:0071941)4.87134937
39regulation of fibrinolysis (GO:0051917)4.80731000
40high-density lipoprotein particle remodeling (GO:0034375)4.80044872
41aromatic amino acid family metabolic process (GO:0009072)4.75248915
42amino-acid betaine metabolic process (GO:0006577)4.67956723
43regulation of complement activation (GO:0030449)4.64306215
44cilium or flagellum-dependent cell motility (GO:0001539)4.52259344
45epoxygenase P450 pathway (GO:0019373)4.50024088
46alpha-amino acid catabolic process (GO:1901606)4.44759176
47ethanol oxidation (GO:0006069)4.42670023
48tyrosine metabolic process (GO:0006570)4.40381373
49cellular glucuronidation (GO:0052695)4.36464241
50omega-hydroxylase P450 pathway (GO:0097267)4.32369149
51* glutamate metabolic process (GO:0006536)4.30295823
52glycoside metabolic process (GO:0016137)4.27030177
53cellular ketone body metabolic process (GO:0046950)4.25806694
54regulation of triglyceride catabolic process (GO:0010896)4.25406378
55drug transmembrane transport (GO:0006855)4.25195853
56negative regulation of cholesterol transport (GO:0032375)4.24313859
57negative regulation of sterol transport (GO:0032372)4.24313859
58reverse cholesterol transport (GO:0043691)4.23608493
59indolalkylamine metabolic process (GO:0006586)4.22875617
60bile acid and bile salt transport (GO:0015721)4.21636218
61* serine family amino acid metabolic process (GO:0009069)4.21047449
62benzene-containing compound metabolic process (GO:0042537)4.19239216
63urate metabolic process (GO:0046415)4.18545216
64motile cilium assembly (GO:0044458)4.18132066
65triglyceride homeostasis (GO:0070328)4.17877833
66acylglycerol homeostasis (GO:0055090)4.17877833
67diterpenoid biosynthetic process (GO:0016102)4.17355267
68cellular modified amino acid catabolic process (GO:0042219)4.17332687
69glycine metabolic process (GO:0006544)4.14273482
70cellular amino acid catabolic process (GO:0009063)4.13495810
71drug catabolic process (GO:0042737)4.11816740
72plasma lipoprotein particle remodeling (GO:0034369)4.11520411
73protein-lipid complex remodeling (GO:0034368)4.11520411
74macromolecular complex remodeling (GO:0034367)4.11520411
75coenzyme catabolic process (GO:0009109)4.11142463
76regulation of cholesterol esterification (GO:0010872)4.10058467
77retinal metabolic process (GO:0042574)4.09153082
78regulation of cholesterol homeostasis (GO:2000188)4.08575734
79protoporphyrinogen IX metabolic process (GO:0046501)4.07856128
80cellular biogenic amine catabolic process (GO:0042402)4.06326586
81amine catabolic process (GO:0009310)4.06326586
82plasma lipoprotein particle clearance (GO:0034381)4.06001526
83progesterone metabolic process (GO:0042448)4.05812023
84dicarboxylic acid biosynthetic process (GO:0043650)4.02653300
85aldehyde catabolic process (GO:0046185)4.02590673
86imidazole-containing compound metabolic process (GO:0052803)4.01074305
87glucuronate metabolic process (GO:0019585)3.98732198
88uronic acid metabolic process (GO:0006063)3.98732198
89intestinal cholesterol absorption (GO:0030299)3.98172040
90serine family amino acid biosynthetic process (GO:0009070)3.97002680
91glycosphingolipid catabolic process (GO:0046479)3.92536701
92phospholipid efflux (GO:0033700)3.92138926
93cholesterol efflux (GO:0033344)3.91456117
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.90174091
95short-chain fatty acid metabolic process (GO:0046459)3.85723414
96acetyl-CoA metabolic process (GO:0006084)3.84109044
97fibrinolysis (GO:0042730)3.75070547
98aspartate family amino acid catabolic process (GO:0009068)3.73820249
99plasma lipoprotein particle assembly (GO:0034377)3.73739143
100very-low-density lipoprotein particle assembly (GO:0034379)3.72538255
101phospholipid homeostasis (GO:0055091)3.69287717
102negative regulation of T cell differentiation in thymus (GO:0033085)3.66158235
103ketone body metabolic process (GO:1902224)3.65947170
104carboxylic acid catabolic process (GO:0046395)3.64091431
105organic acid catabolic process (GO:0016054)3.64091431
106oligosaccharide catabolic process (GO:0009313)3.63823119
107cofactor catabolic process (GO:0051187)3.62953288
108exogenous drug catabolic process (GO:0042738)3.61912499
109glycolipid catabolic process (GO:0019377)3.61765944
110cholesterol homeostasis (GO:0042632)3.55725615
111fatty acid oxidation (GO:0019395)3.55174532
112carnitine metabolic process (GO:0009437)3.54356914
113vitamin transmembrane transport (GO:0035461)3.53269133
114sterol homeostasis (GO:0055092)3.53172378
115positive regulation of extracellular matrix organization (GO:1903055)3.52455148
116arginine metabolic process (GO:0006525)3.50893834
117flavonoid metabolic process (GO:0009812)3.50315923
118regulation of bile acid biosynthetic process (GO:0070857)3.49066916
1192-oxoglutarate metabolic process (GO:0006103)3.48580942
120fatty acid beta-oxidation (GO:0006635)3.48015375
121lipid oxidation (GO:0034440)3.47960909
122heme transport (GO:0015886)3.47105673
123primary alcohol metabolic process (GO:0034308)3.45944497
124drug transport (GO:0015893)3.45110288
125protein-lipid complex assembly (GO:0065005)3.44859846
126* response to nitrosative stress (GO:0051409)3.44023511
127low-density lipoprotein particle clearance (GO:0034383)3.42498844
128cellular response to thyroid hormone stimulus (GO:0097067)3.41156619
129fat-soluble vitamin biosynthetic process (GO:0042362)3.37347957
130cilium movement (GO:0003341)3.34022496
131pyrimidine-containing compound transmembrane transport (GO:0072531)3.33741125
132retinoic acid metabolic process (GO:0042573)3.27116387
133epithelial cell differentiation involved in prostate gland development (GO:0060742)3.24530049
134protoporphyrinogen IX biosynthetic process (GO:0006782)3.22416283
135regulation of apoptotic cell clearance (GO:2000425)3.20978108
136negative regulation of fatty acid biosynthetic process (GO:0045717)3.19115128
137regulation of cholesterol storage (GO:0010885)3.12669313
138ceramide catabolic process (GO:0046514)3.10012007
139negative regulation of humoral immune response (GO:0002921)2.97140763
140desmosome organization (GO:0002934)2.96671705
141cellular copper ion homeostasis (GO:0006878)2.94511352
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93294262
143response to thyroid hormone (GO:0097066)2.92266639
144positive regulation of blood coagulation (GO:0030194)2.87256271
145positive regulation of hemostasis (GO:1900048)2.87256271
146positive regulation of coagulation (GO:0050820)2.86867282
147drug metabolic process (GO:0017144)2.86527145
148positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.86012912
149S-adenosylmethionine metabolic process (GO:0046500)2.86008774
150negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85896219
151negative regulation of B cell mediated immunity (GO:0002713)2.85896219
152C21-steroid hormone metabolic process (GO:0008207)2.85061446
153cellular aldehyde metabolic process (GO:0006081)2.81480626
154porphyrin-containing compound metabolic process (GO:0006778)2.80917716
155hemidesmosome assembly (GO:0031581)2.80909885
156regulation of cholesterol biosynthetic process (GO:0045540)2.80263589
157N-acetylneuraminate metabolic process (GO:0006054)2.79486360
158hemoglobin metabolic process (GO:0020027)2.79481902
159positive regulation of lipoprotein lipase activity (GO:0051006)2.79410614
160positive regulation of triglyceride lipase activity (GO:0061365)2.79410614
161plasma lipoprotein particle organization (GO:0071827)2.73661987
162one-carbon compound transport (GO:0019755)2.70035826
163regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.67991514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.76032869
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73305409
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.21017660
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.18433189
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.73994670
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.51299693
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45749169
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.36981771
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97865123
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.50511878
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19971141
12CLOCK_20551151_ChIP-Seq_293T_Human2.15779968
13GATA1_22025678_ChIP-Seq_K562_Human2.08398260
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04527898
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03285218
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00135606
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8574757
18MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90873198
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85285199
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85285199
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.83961246
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.78248563
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77606747
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58291580
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56702685
26* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44450778
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43921298
28* RUNX1_27514584_Chip-Seq_MCF-7_Human1.40441610
29* ATF3_27146783_Chip-Seq_COLON_Human1.35003842
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34681751
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34252327
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.33452173
33* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28933340
34GATA4_25053715_ChIP-Seq_YYC3_Human1.27919317
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24786272
36ZNF263_19887448_ChIP-Seq_K562_Human1.21775249
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20418054
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.20139471
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18899641
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.14356157
41* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09834792
42* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08447114
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04734692
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04057435
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03735343
46SCL_19346495_ChIP-Seq_HPC-7_Human1.02551455
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00547953
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00453483
49KLF5_25053715_ChIP-Seq_YYC3_Human1.00258732
50* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99321805
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97714003
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97235186
53* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96294455
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95374597
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94915700
56CHD1_26751641_Chip-Seq_LNCaP_Human0.94712032
57HTT_18923047_ChIP-ChIP_STHdh_Human0.93604115
58RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93565823
59VDR_24787735_ChIP-Seq_THP-1_Human0.93344956
60ESR1_20079471_ChIP-ChIP_T-47D_Human0.92907353
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92449827
62GATA6_25053715_ChIP-Seq_YYC3_Human0.92196291
63AHR_22903824_ChIP-Seq_MCF-7_Human0.91819738
64CDX2_20551321_ChIP-Seq_CACO-2_Human0.91160479
65* TCF7_22412390_ChIP-Seq_EML_Mouse0.91149076
66* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90555080
67* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90555080
68* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90136566
69* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89898507
70KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89187941
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88320845
72IRF8_22096565_ChIP-ChIP_GC-B_Human0.87087058
73GATA1_19941826_ChIP-Seq_K562_Human0.83578218
74* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81590747
75TP53_22127205_ChIP-Seq_IMR90_Human0.78280209
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77860222
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76851554
78GATA2_19941826_ChIP-Seq_K562_Human0.76450718
79* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75891180
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75762764
81PU_27001747_Chip-Seq_BMDM_Mouse0.75617318
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75540593
83SOX2_20726797_ChIP-Seq_SW620_Human0.75227559
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75078510
85* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75033281
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73753218
87TRIM28_21343339_ChIP-Seq_HEK293_Human0.72716052
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70946849
89FOXA1_25552417_ChIP-Seq_VCAP_Human0.70699686
90RACK7_27058665_Chip-Seq_MCF-7_Human0.67934783
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67839591
92EGR1_19032775_ChIP-ChIP_M12_Human0.67464270
93* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66180605
94* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66010278
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64045108
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63127063
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62544146
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61971008
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.61659087
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.61500695
101LXR_22292898_ChIP-Seq_THP-1_Human0.60276426
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59801098
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.59228037
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58631522
105* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57694072
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57681527
107CEBPB_22108803_ChIP-Seq_LS180_Human0.56906512
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.55990000
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.55798007
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.55479092
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.54645122
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.53750669
113CDX2_22108803_ChIP-Seq_LS180_Human0.52223749
114AR_21909140_ChIP-Seq_LNCAP_Human0.51935165
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.51356140
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50612166
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49642048
118* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.48709645
119TP63_23658742_ChIP-Seq_EP156T_Human0.48563869
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.47692127
121* CREB1_26743006_Chip-Seq_LNCaP_Human0.47686830
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.46393704
123* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.46051885
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.45791992
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45263102
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.44830246
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.44449389
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.44449389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.06578820
2MP0005360_urolithiasis7.37237493
3MP0005085_abnormal_gallbladder_physiolo6.00959079
4MP0005365_abnormal_bile_salt5.70451365
5MP0008875_abnormal_xenobiotic_pharmacok5.03614653
6MP0003806_abnormal_nucleotide_metabolis4.03545643
7MP0003252_abnormal_bile_duct3.89782221
8MP0005083_abnormal_biliary_tract3.26877147
9MP0010329_abnormal_lipoprotein_level3.25818997
10MP0009840_abnormal_foam_cell2.88760841
11MP0005332_abnormal_amino_acid2.86011714
12MP0002138_abnormal_hepatobiliary_system2.73272042
13MP0003195_calcinosis2.70493113
14MP0001666_abnormal_nutrient_absorption2.57019130
15MP0004147_increased_porphyrin_level2.51467968
16MP0003191_abnormal_cellular_cholesterol2.42476147
17MP0004019_abnormal_vitamin_homeostasis2.33909455
18* MP0000609_abnormal_liver_physiology2.04460601
19MP0002118_abnormal_lipid_homeostasis2.00464217
20MP0005319_abnormal_enzyme/_coenzyme1.75157572
21MP0003868_abnormal_feces_composition1.69115948
22MP0003172_abnormal_lysosome_physiology1.66166348
23MP0009643_abnormal_urine_homeostasis1.57361332
24MP0005584_abnormal_enzyme/coenzyme_acti1.55792051
25MP0000383_abnormal_hair_follicle1.40266918
26MP0003656_abnormal_erythrocyte_physiolo1.38665796
27MP0003186_abnormal_redox_activity1.38169792
28MP0003566_abnormal_cell_adhesion1.34123675
29MP0002877_abnormal_melanocyte_morpholog1.33256298
30MP0000858_altered_metastatic_potential1.32728279
31MP0004185_abnormal_adipocyte_glucose1.27501081
32MP0003705_abnormal_hypodermis_morpholog1.22095772
33MP0003303_peritoneal_inflammation1.21335146
34MP0001764_abnormal_homeostasis1.21098733
35MP0000685_abnormal_immune_system1.19571229
36MP0004782_abnormal_surfactant_physiolog1.19495680
37MP0002132_abnormal_respiratory_system1.18591290
38MP0005636_abnormal_mineral_homeostasis1.18497024
39MP0010234_abnormal_vibrissa_follicle1.17825638
40MP0002254_reproductive_system_inflammat1.16618364
41MP0005451_abnormal_body_composition1.14358462
42MP0000598_abnormal_liver_morphology1.12994700
43MP0000604_amyloidosis1.12254952
44MP0001216_abnormal_epidermal_layer1.11956400
45MP0005076_abnormal_cell_differentiation1.09138743
46MP0003011_delayed_dark_adaptation1.08345218
47MP0005647_abnormal_sex_gland1.08293841
48MP0005397_hematopoietic_system_phenotyp1.07095533
49MP0001545_abnormal_hematopoietic_system1.07095533
50MP0003632_abnormal_nervous_system1.04510572
51MP0009764_decreased_sensitivity_to1.02546787
52MP0008260_abnormal_autophagy0.97363877
53MP0002098_abnormal_vibrissa_morphology0.96805587
54MP0005310_abnormal_salivary_gland0.96533676
55MP0003950_abnormal_plasma_membrane0.92004650
56MP0002419_abnormal_innate_immunity0.91417283
57MP0008057_abnormal_DNA_replication0.90767410
58MP0001756_abnormal_urination0.89750655
59MP0009763_increased_sensitivity_to0.89741571
60MP0003941_abnormal_skin_development0.88807888
61MP0010155_abnormal_intestine_physiology0.87998766
62MP0002998_abnormal_bone_remodeling0.87930927
63MP0005408_hypopigmentation0.87175347
64MP0002136_abnormal_kidney_physiology0.87057745
65MP0005165_increased_susceptibility_to0.86875247
66MP0010368_abnormal_lymphatic_system0.86647700
67MP0001915_intracranial_hemorrhage0.86327034
68MP0009785_altered_susceptibility_to0.85518264
69MP0008469_abnormal_protein_level0.84834252
70MP0009697_abnormal_copulation0.84595421
71MP0003690_abnormal_glial_cell0.84327713
72MP0003828_pulmonary_edema0.83449146
73MP0003300_gastrointestinal_ulcer0.82094972
74MP0002405_respiratory_system_inflammati0.81155882
75MP0005501_abnormal_skin_physiology0.80921008
76MP0010352_gastrointestinal_tract_polyps0.80422564
77MP0009642_abnormal_blood_homeostasis0.80411779
78MP0004043_abnormal_pH_regulation0.78782816
79MP0000627_abnormal_mammary_gland0.78426828
80MP0009765_abnormal_xenobiotic_induced0.78211560
81MP0001727_abnormal_embryo_implantation0.77535154
82MP0003329_amyloid_beta_deposits0.75922246
83MP0004808_abnormal_hematopoietic_stem0.75796856
84MP0003634_abnormal_glial_cell0.74530557
85MP0000343_altered_response_to0.72329929
86MP0000762_abnormal_tongue_morphology0.71809722
87MP0005025_abnormal_response_to0.71705949
88MP0002796_impaired_skin_barrier0.70770025
89MP0005058_abnormal_lysosome_morphology0.69471093
90MP0005376_homeostasis/metabolism_phenot0.68408105
91MP0002928_abnormal_bile_duct0.66345574
92MP0001853_heart_inflammation0.66034665
93MP0004264_abnormal_extraembryonic_tissu0.65863607
94MP0009931_abnormal_skin_appearance0.65060784
95MP0005084_abnormal_gallbladder_morpholo0.64405035
96MP0002078_abnormal_glucose_homeostasis0.63823364
97MP0005220_abnormal_exocrine_pancreas0.62600830
98MP0006036_abnormal_mitochondrial_physio0.62427017
99MP0001661_extended_life_span0.61404992
100MP0001765_abnormal_ion_homeostasis0.61097737
101MP0002971_abnormal_brown_adipose0.60044872
102MP0005334_abnormal_fat_pad0.59927369
103MP0001849_ear_inflammation0.59284190
104MP0003453_abnormal_keratinocyte_physiol0.58896804
105MP0010307_abnormal_tumor_latency0.58328781
106MP0004130_abnormal_muscle_cell0.58098646
107MP0009053_abnormal_anal_canal0.58056459
108MP0003724_increased_susceptibility_to0.57887057
109MP0005166_decreased_susceptibility_to0.56719801
110MP0005464_abnormal_platelet_physiology0.56311724
111MP0003638_abnormal_response/metabolism_0.54505571
112MP0005535_abnormal_body_temperature0.53703901
113MP0003075_altered_response_to0.52284715
114MP0008873_increased_physiological_sensi0.51532279
115MP0003436_decreased_susceptibility_to0.49698800
116MP0005266_abnormal_metabolism0.49194791
117MP0002876_abnormal_thyroid_physiology0.48249551
118MP0005167_abnormal_blood-brain_barrier0.47816868
119MP0000639_abnormal_adrenal_gland0.47609928
120MP0002168_other_aberrant_phenotype0.45923004
121MP0005395_other_phenotype0.45312013
122MP0008874_decreased_physiological_sensi0.45239366
123MP0005666_abnormal_adipose_tissue0.42523537
124MP0005248_abnormal_Harderian_gland0.42027510
125MP0004947_skin_inflammation0.41742355
126MP0006082_CNS_inflammation0.41696498
127MP0002295_abnormal_pulmonary_circulatio0.40232352
128MP0001177_atelectasis0.39526985
129MP0005164_abnormal_response_to0.39255510
130MP0001881_abnormal_mammary_gland0.39063854
131MP0006035_abnormal_mitochondrial_morpho0.38570807
132MP0009384_cardiac_valve_regurgitation0.37738140
133MP0005448_abnormal_energy_balance0.37302605
134MP0002135_abnormal_kidney_morphology0.37289106
135MP0008872_abnormal_physiological_respon0.37237799
136MP0010678_abnormal_skin_adnexa0.36455920
137MP0000249_abnormal_blood_vessel0.35940539
138MP0001845_abnormal_inflammatory_respons0.34844806
139MP0004883_abnormal_blood_vessel0.33880365
140MP0005023_abnormal_wound_healing0.32448861
141MP0003953_abnormal_hormone_level0.32289957
142MP0008961_abnormal_basal_metabolism0.32105912

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.05743140
2Deep venous thrombosis (HP:0002625)6.75727005
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.68334997
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.37669097
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.21871531
6Xanthomatosis (HP:0000991)5.83442061
7Hypobetalipoproteinemia (HP:0003563)5.71782631
8Prolonged partial thromboplastin time (HP:0003645)5.42850883
9Abnormal respiratory motile cilium physiology (HP:0012261)5.05636746
10Rhinitis (HP:0012384)5.02548290
11Complement deficiency (HP:0004431)4.99279750
12Absent/shortened dynein arms (HP:0200106)4.91815851
13Dynein arm defect of respiratory motile cilia (HP:0012255)4.91815851
14Abnormal respiratory motile cilium morphology (HP:0005938)4.90977247
15Abnormal respiratory epithelium morphology (HP:0012253)4.90977247
16Hyperlipoproteinemia (HP:0010980)4.78299791
17Nasal polyposis (HP:0100582)4.62075809
18Chronic bronchitis (HP:0004469)4.58699943
19Abnormal ciliary motility (HP:0012262)4.54146439
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.47794854
21Hyperammonemia (HP:0001987)4.24312082
22Abnormality of glycolipid metabolism (HP:0010969)4.24205088
23Abnormality of liposaccharide metabolism (HP:0010968)4.24205088
24Abnormality of glycosphingolipid metabolism (HP:0004343)4.24205088
25Epidermoid cyst (HP:0200040)4.21345089
26Hypolipoproteinemia (HP:0010981)4.18486031
27Abnormality of sulfur amino acid metabolism (HP:0004339)4.16213488
28Joint hemorrhage (HP:0005261)4.15713987
29Hyperglycinemia (HP:0002154)4.14872354
30Abnormality of the nasal mucosa (HP:0000433)4.08954628
31Fat malabsorption (HP:0002630)4.07111511
32Ketosis (HP:0001946)4.02094513
33Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00593160
34Abnormality of the common coagulation pathway (HP:0010990)3.99597947
35Hyperglycinuria (HP:0003108)3.98386702
36Abnormality of glycine metabolism (HP:0010895)3.92274915
37Abnormality of serine family amino acid metabolism (HP:0010894)3.92274915
38Gout (HP:0001997)3.86304023
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.86121145
40Bronchiectasis (HP:0002110)3.72557322
41Abnormality of methionine metabolism (HP:0010901)3.66801386
42Abnormality of complement system (HP:0005339)3.61473717
43Hypoalphalipoproteinemia (HP:0003233)3.53266860
44Abnormality of purine metabolism (HP:0004352)3.35510142
45Hypoglycemic coma (HP:0001325)3.32668217
46Conjugated hyperbilirubinemia (HP:0002908)3.31468483
47Abnormality of nucleobase metabolism (HP:0010932)3.28580516
48Hypercholesterolemia (HP:0003124)3.27215147
49Abnormality of the intrinsic pathway (HP:0010989)3.22964218
50Delayed CNS myelination (HP:0002188)3.21208172
51Hepatocellular carcinoma (HP:0001402)3.18381127
52Vacuolated lymphocytes (HP:0001922)3.14722933
53Abnormality of pyrimidine metabolism (HP:0004353)3.14721264
54Abnormality of fatty-acid metabolism (HP:0004359)3.12798020
55Hyperbilirubinemia (HP:0002904)3.12596455
56Ketoacidosis (HP:0001993)3.10647863
57Steatorrhea (HP:0002570)3.09650640
58Neurofibrillary tangles (HP:0002185)3.01118562
59Hypochromic microcytic anemia (HP:0004840)2.96562467
60Increased cerebral lipofuscin (HP:0011813)2.93737419
61Vascular calcification (HP:0004934)2.90248275
62Acanthocytosis (HP:0001927)2.87684801
63Myocardial infarction (HP:0001658)2.83725496
64Bronchitis (HP:0012387)2.83081486
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81167772
66Metabolic acidosis (HP:0001942)2.76605033
67Thoracic kyphosis (HP:0002942)2.75689651
68Cerebral inclusion bodies (HP:0100314)2.71816954
69Thick nail (HP:0001805)2.69536378
70Malnutrition (HP:0004395)2.69478878
71Spastic diplegia (HP:0001264)2.68980674
72Abnormal gallbladder physiology (HP:0012438)2.66139148
73Cholecystitis (HP:0001082)2.66139148
74Abnormality of serum amino acid levels (HP:0003112)2.64324249
75Hyperuricemia (HP:0002149)2.64006644
76Increased purine levels (HP:0004368)2.64006644
77Dysostosis multiplex (HP:0000943)2.63831459
78Spontaneous abortion (HP:0005268)2.63733768
79Esophageal varix (HP:0002040)2.63226653
80Cardiovascular calcification (HP:0011915)2.55437295
81Skin nodule (HP:0200036)2.54031224
82Flat acetabular roof (HP:0003180)2.53918074
83Increased serum ferritin (HP:0003281)2.52012630
84Sensorimotor neuropathy (HP:0007141)2.50886127
85Abnormal gallbladder morphology (HP:0012437)2.48683376
86Cholelithiasis (HP:0001081)2.46853925
87Urinary glycosaminoglycan excretion (HP:0003541)2.44935621
88Mucopolysacchariduria (HP:0008155)2.44935621
89Disinhibition (HP:0000734)2.42605117
90Alkalosis (HP:0001948)2.42563579
91Recurrent otitis media (HP:0000403)2.40604536
92Systemic lupus erythematosus (HP:0002725)2.40201904
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.39289487
94Male infertility (HP:0003251)2.35097351
95Rickets (HP:0002748)2.32235129
96Lethargy (HP:0001254)2.31749413
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31001990
98Abnormality of polysaccharide metabolism (HP:0011012)2.31001990
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31001990
100Tetraparesis (HP:0002273)2.28861698
101Recurrent gram-negative bacterial infections (HP:0005420)2.28855637
102Dicarboxylic aciduria (HP:0003215)2.27326795
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27326795
104Chronic otitis media (HP:0000389)2.26801063
105Mitral stenosis (HP:0001718)2.24955647
106Irritability (HP:0000737)2.24783890
107Neonatal onset (HP:0003623)2.23073623
108Global brain atrophy (HP:0002283)2.22905493
109Abnormality of the thoracic spine (HP:0100711)2.22441419
110Abnormality of proline metabolism (HP:0010907)2.21441307
111Hydroxyprolinuria (HP:0003080)2.21441307
112Chronic sinusitis (HP:0011109)2.21083344
113Proximal tubulopathy (HP:0000114)2.20336977
114Poikilocytosis (HP:0004447)2.19637615
115Reticulocytosis (HP:0001923)2.14582970
116Recurrent sinusitis (HP:0011108)2.14477629
117Diaphragmatic weakness (HP:0009113)2.13416751
118Amyloidosis (HP:0011034)2.13260842
119Glomerulonephritis (HP:0000099)2.09423573
120Abnormality of the heme biosynthetic pathway (HP:0010472)2.09254271
121Hypoglycemic seizures (HP:0002173)2.08772241
122Abnormal enzyme/coenzyme activity (HP:0012379)2.08347607
123Late onset (HP:0003584)2.05951417
124Loss of speech (HP:0002371)2.05493297
125Vomiting (HP:0002013)2.05120881
126Abnormality of the gallbladder (HP:0005264)2.04603856
127Axonal loss (HP:0003447)2.00849471
128Hyperactive renin-angiotensin system (HP:0000841)1.99753572
129Hemorrhage of the eye (HP:0011885)1.99419858
130Infertility (HP:0000789)1.99054039
131Abnormal cartilage morphology (HP:0002763)1.96141143
132Menorrhagia (HP:0000132)1.95137087
133Gingival bleeding (HP:0000225)1.94802342
134Enlarged kidneys (HP:0000105)1.93863089
135Pathologic fracture (HP:0002756)1.93442421
136Pancreatitis (HP:0001733)1.92550004
137Abnormality of transition element cation homeostasis (HP:0011030)1.91836699
138Thrombophlebitis (HP:0004418)1.90867318
139Interstitial pulmonary disease (HP:0006530)1.90502357
140Nephritis (HP:0000123)1.90214677
141Glomerulosclerosis (HP:0000096)1.89888700
142Back pain (HP:0003418)1.88451742
143Milia (HP:0001056)1.87890503
144Abnormality of iron homeostasis (HP:0011031)1.87105559
145Nausea (HP:0002018)1.86677422
146Brushfield spots (HP:0001088)1.85714893
147Tachypnea (HP:0002789)1.85348558
148Polycythemia (HP:0001901)1.85142233
149Hypophosphatemic rickets (HP:0004912)1.84955932
150Generalized aminoaciduria (HP:0002909)1.84626695
151Autoimmune thrombocytopenia (HP:0001973)1.83743498
152Coarse hair (HP:0002208)1.77955092
153Paralysis (HP:0003470)1.77780062
154Pustule (HP:0200039)1.77480614
155Hypoplasia of dental enamel (HP:0006297)1.77080406
156Metaphyseal irregularity (HP:0003025)1.77049133
157Abnormality of chloride homeostasis (HP:0011422)1.76780238
158Bone pain (HP:0002653)1.70885414
159Recurrent bacterial skin infections (HP:0005406)1.70031070
160Osteomalacia (HP:0002749)1.69539493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.49470242
2FGFR43.97095892
3ERN13.63619241
4SIK13.37285380
5ERBB42.86987450
6TAOK32.83498399
7MST1R2.76470507
8SMG12.36171757
9EPHA22.24955889
10EIF2AK12.23424058
11FGFR22.15196736
12EPHB11.99929521
13ACVR1B1.89050962
14PTK61.88584860
15LATS11.81234617
16TAOK21.81232241
17PRPF4B1.81138206
18WNK41.77993817
19NME21.77147469
20FRK1.76917213
21OXSR11.76169378
22TAOK11.72747654
23TRIB31.72208876
24CDK121.69398369
25PKN21.68831005
26MAP3K101.68673021
27MAP3K121.61422703
28PAK41.59883015
29TRPM71.59447033
30NEK61.56389809
31MAP2K41.56021284
32NEK91.55209652
33SCYL21.52239773
34MET1.52101721
35HIPK21.50845751
36MAPK111.49750256
37INSRR1.47936551
38WNK31.47598730
39AKT31.47345591
40DAPK21.42000389
41CDK61.41878765
42MAP3K31.39572440
43TYK21.38406458
44STK241.35745265
45MAP3K71.33302100
46GRK61.31662552
47ABL21.30533665
48RIPK11.30240784
49LRRK21.20263586
50CAMK1D1.15115588
51PTK21.13044808
52JAK21.11020288
53MAP3K21.10367721
54ERBB21.09244137
55PBK1.08486736
56GSK3A1.07606991
57STK101.07142593
58MAPK151.05282708
59FGR1.05133745
60FLT31.03646153
61JAK11.01343742
62EEF2K1.00123655
63CAMK1G0.99334833
64TBK10.98515204
65SGK30.97522294
66MAP2K30.96927192
67CAMKK20.96521320
68STK390.91932899
69TGFBR20.91644181
70TTK0.89931474
71DYRK1B0.89123847
72MAP3K140.87523140
73MATK0.87094807
74MAP3K90.86952280
75CHUK0.85860645
76STK30.84840983
77PRKAA20.84502551
78IKBKB0.83613276
79BMX0.81501652
80PIK3CG0.79537123
81ERBB30.78560554
82FGFR30.77494632
83LATS20.70390577
84CSK0.70201683
85SGK4940.70016916
86SGK2230.70016916
87MAPK40.69580667
88PDPK10.69347836
89EPHA30.68263188
90MAP2K20.67667300
91EIF2AK30.67269448
92STK38L0.66746161
93EGFR0.66513799
94MAP2K10.66354191
95PRKCZ0.64273018
96BRSK20.64149818
97KSR10.63363329
98MAPKAPK30.61842156
99MTOR0.60778524
100MAP3K110.60498560
101GRK70.59745571
102BMPR20.59702739
103PRKCQ0.59416578
104IRAK30.58731304
105FER0.57474895
106PDK20.57317836
107BRAF0.56916939
108ICK0.56775044
109CSNK1G10.55738389
110PRKACG0.53532667
111RET0.52649392
112PRKCI0.52296285
113KSR20.50787155
114CAMK2G0.49736180
115MAP3K130.49046210
116SGK20.47936620
117WNK10.47894049
118KDR0.47888784
119TGFBR10.44814163
120MAP3K10.44779352
121PAK30.44189449
122BRD40.44183502
123PRKAA10.43926457
124PDGFRB0.42824070
125MAP3K50.42761422
126CSNK1A1L0.40490745
127RPS6KB10.40254441
128ABL10.39999245
129CDK40.39597703
130PNCK0.39196295
131ZAP700.39078545
132NTRK10.38549781
133CDC42BPA0.37677555
134CSNK1G20.37425008
135MAPK120.37205617
136CSF1R0.36923160
137PDGFRA0.36404658
138MELK0.36307426
139PDK10.36306478
140PIM10.35843759
141MAP3K80.35527746
142LMTK20.35126215
143ARAF0.33977075
144MST40.33947998
145IKBKE0.32732196
146IGF1R0.31780467
147SGK10.31420378
148ALK0.29543323

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27934259
2Nitrogen metabolism_Homo sapiens_hsa009103.73035866
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48801052
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12586637
5Arginine biosynthesis_Homo sapiens_hsa002202.87010150
6Tryptophan metabolism_Homo sapiens_hsa003802.74669411
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64855600
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62420076
9Complement and coagulation cascades_Homo sapiens_hsa046102.53908270
10Fatty acid degradation_Homo sapiens_hsa000712.52008779
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42306010
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41846400
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41006925
14Butanoate metabolism_Homo sapiens_hsa006502.30543097
15Other glycan degradation_Homo sapiens_hsa005112.26855397
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20318502
17Peroxisome_Homo sapiens_hsa041462.13268225
18Chemical carcinogenesis_Homo sapiens_hsa052041.98724447
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98277871
20Propanoate metabolism_Homo sapiens_hsa006401.94896471
21Histidine metabolism_Homo sapiens_hsa003401.94846114
22PPAR signaling pathway_Homo sapiens_hsa033201.88935456
23Fatty acid metabolism_Homo sapiens_hsa012121.83641333
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.76990941
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74189251
26beta-Alanine metabolism_Homo sapiens_hsa004101.73286426
27Bile secretion_Homo sapiens_hsa049761.70294926
28Selenocompound metabolism_Homo sapiens_hsa004501.66788052
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66354565
30Retinol metabolism_Homo sapiens_hsa008301.65850942
31Caffeine metabolism_Homo sapiens_hsa002321.63750281
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.57407953
33Staphylococcus aureus infection_Homo sapiens_hsa051501.54644280
34Sulfur metabolism_Homo sapiens_hsa009201.49021965
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48082130
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48002750
37Phenylalanine metabolism_Homo sapiens_hsa003601.41351502
38Pyruvate metabolism_Homo sapiens_hsa006201.40819420
39Fatty acid elongation_Homo sapiens_hsa000621.29550140
40Tyrosine metabolism_Homo sapiens_hsa003501.29151652
41ABC transporters_Homo sapiens_hsa020101.26318114
42Steroid biosynthesis_Homo sapiens_hsa001001.26289898
43Starch and sucrose metabolism_Homo sapiens_hsa005001.23433179
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.22930308
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20863930
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19969825
47* Cysteine and methionine metabolism_Homo sapiens_hsa002701.12967403
48Sphingolipid metabolism_Homo sapiens_hsa006001.12639054
49Carbon metabolism_Homo sapiens_hsa012001.12497785
50Biosynthesis of amino acids_Homo sapiens_hsa012301.09080129
51Folate biosynthesis_Homo sapiens_hsa007901.08107339
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04694966
53Fat digestion and absorption_Homo sapiens_hsa049751.02147396
54Vitamin digestion and absorption_Homo sapiens_hsa049771.01699950
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98418709
56Lysine degradation_Homo sapiens_hsa003100.93459978
57Arginine and proline metabolism_Homo sapiens_hsa003300.92564266
58Sulfur relay system_Homo sapiens_hsa041220.86246696
59* Glutathione metabolism_Homo sapiens_hsa004800.85647214
60Vitamin B6 metabolism_Homo sapiens_hsa007500.84353396
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81798576
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.80935605
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79490823
64Glycerolipid metabolism_Homo sapiens_hsa005610.74535995
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72268821
66Arachidonic acid metabolism_Homo sapiens_hsa005900.69384491
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68340937
68Fatty acid biosynthesis_Homo sapiens_hsa000610.67793925
69Pentose phosphate pathway_Homo sapiens_hsa000300.64754185
70One carbon pool by folate_Homo sapiens_hsa006700.63524389
71Legionellosis_Homo sapiens_hsa051340.48895554
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45357858
73Malaria_Homo sapiens_hsa051440.41530049
74* Metabolic pathways_Homo sapiens_hsa011000.37738226
75Osteoclast differentiation_Homo sapiens_hsa043800.36752295
76Pertussis_Homo sapiens_hsa051330.36428083
77Toxoplasmosis_Homo sapiens_hsa051450.35565940
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35546158
79Chronic myeloid leukemia_Homo sapiens_hsa052200.34365200
80Tuberculosis_Homo sapiens_hsa051520.33417179
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33289147
82Collecting duct acid secretion_Homo sapiens_hsa049660.33212736
83Prion diseases_Homo sapiens_hsa050200.33019427
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32967772
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.32759814
86Pancreatic cancer_Homo sapiens_hsa052120.32520391
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.29551623
88TNF signaling pathway_Homo sapiens_hsa046680.26870292
89Thyroid cancer_Homo sapiens_hsa052160.26506237
90Insulin resistance_Homo sapiens_hsa049310.25793147
91Apoptosis_Homo sapiens_hsa042100.25373959
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24991886
93Antigen processing and presentation_Homo sapiens_hsa046120.24962787
94Phagosome_Homo sapiens_hsa041450.23636107
95Leishmaniasis_Homo sapiens_hsa051400.18895909
96Fructose and mannose metabolism_Homo sapiens_hsa000510.18321040
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17952450
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17177391
99Acute myeloid leukemia_Homo sapiens_hsa052210.16253364
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16236237
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.15756017
102Mineral absorption_Homo sapiens_hsa049780.14418398
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.14358924
104Vibrio cholerae infection_Homo sapiens_hsa051100.13679537
105Galactose metabolism_Homo sapiens_hsa000520.07363345
106AMPK signaling pathway_Homo sapiens_hsa041520.03375129
107Linoleic acid metabolism_Homo sapiens_hsa005910.01672935
108Glucagon signaling pathway_Homo sapiens_hsa049220.00580435
109African trypanosomiasis_Homo sapiens_hsa05143-0.1998004
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1897606
111Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1853666
112Protein digestion and absorption_Homo sapiens_hsa04974-0.1740194
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1621255
114Ether lipid metabolism_Homo sapiens_hsa00565-0.1572072
115Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1415622
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1336639
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1334696
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1331575
119Insulin signaling pathway_Homo sapiens_hsa04910-0.1249613
120Amoebiasis_Homo sapiens_hsa05146-0.1162635
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0973344
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0914235
123Lysosome_Homo sapiens_hsa04142-0.0629897
124Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0548470
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0389740
126Renin-angiotensin system_Homo sapiens_hsa04614-0.0343189
127Hepatitis C_Homo sapiens_hsa05160-0.0217782
128Bladder cancer_Homo sapiens_hsa05219-0.0016652

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