GCLM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.26468366
2L-phenylalanine catabolic process (GO:0006559)6.92039981
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.92039981
4L-phenylalanine metabolic process (GO:0006558)6.74282270
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74282270
6primary alcohol catabolic process (GO:0034310)6.25699052
7aromatic amino acid family catabolic process (GO:0009074)6.10341008
8* cysteine metabolic process (GO:0006534)5.86314489
9glycoside metabolic process (GO:0016137)5.50504591
10glyoxylate metabolic process (GO:0046487)5.42933119
11retinal metabolic process (GO:0042574)5.39439214
12tryptophan catabolic process (GO:0006569)5.33581545
13indole-containing compound catabolic process (GO:0042436)5.33581545
14indolalkylamine catabolic process (GO:0046218)5.33581545
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.22632249
16lysine catabolic process (GO:0006554)5.13487723
17lysine metabolic process (GO:0006553)5.13487723
18bile acid biosynthetic process (GO:0006699)5.12502958
19kynurenine metabolic process (GO:0070189)5.03562098
20tryptophan metabolic process (GO:0006568)5.01737909
21sulfur amino acid catabolic process (GO:0000098)4.96609800
22alpha-linolenic acid metabolic process (GO:0036109)4.70184672
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.54995326
24aldehyde catabolic process (GO:0046185)4.46545712
25aromatic amino acid family metabolic process (GO:0009072)4.45066070
26diterpenoid biosynthetic process (GO:0016102)4.42163743
27drug transmembrane transport (GO:0006855)4.41578104
28bile acid metabolic process (GO:0008206)4.39616115
29urea cycle (GO:0000050)4.39152377
30urea metabolic process (GO:0019627)4.39152377
31serine family amino acid catabolic process (GO:0009071)4.38299464
32complement activation, alternative pathway (GO:0006957)4.33215689
33amino-acid betaine metabolic process (GO:0006577)4.30596572
34peptidyl-glutamic acid carboxylation (GO:0017187)4.29286440
35protein carboxylation (GO:0018214)4.29286440
36homocysteine metabolic process (GO:0050667)4.22616186
37regulation of type B pancreatic cell apoptotic process (GO:2000674)4.22272261
38high-density lipoprotein particle remodeling (GO:0034375)4.21873773
39negative regulation of fibrinolysis (GO:0051918)4.20883434
40progesterone metabolic process (GO:0042448)4.19876358
41* serine family amino acid metabolic process (GO:0009069)4.17797186
42cofactor catabolic process (GO:0051187)4.17164989
43ethanol oxidation (GO:0006069)4.15978952
44heme transport (GO:0015886)4.15591481
45nitrogen cycle metabolic process (GO:0071941)4.14361010
46serine family amino acid biosynthetic process (GO:0009070)4.12623735
47urate metabolic process (GO:0046415)4.12201735
48alpha-amino acid catabolic process (GO:1901606)4.09906160
49quinone metabolic process (GO:1901661)4.09852018
50regulation of protein activation cascade (GO:2000257)4.09333048
51iron ion import (GO:0097286)4.06019371
52short-chain fatty acid metabolic process (GO:0046459)4.05275098
53cellular glucuronidation (GO:0052695)4.03794504
54cellular ketone body metabolic process (GO:0046950)4.02047745
55regulation of fibrinolysis (GO:0051917)3.98390396
56plasma lipoprotein particle clearance (GO:0034381)3.95720028
57* glutamate metabolic process (GO:0006536)3.94922738
58tyrosine metabolic process (GO:0006570)3.94852970
59coenzyme catabolic process (GO:0009109)3.89610422
60cellular amino acid catabolic process (GO:0009063)3.89594551
61protein-lipid complex remodeling (GO:0034368)3.89566273
62macromolecular complex remodeling (GO:0034367)3.89566273
63plasma lipoprotein particle remodeling (GO:0034369)3.89566273
64regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.87886680
65regulation of triglyceride catabolic process (GO:0010896)3.86783300
66protoporphyrinogen IX metabolic process (GO:0046501)3.83641386
67regulation of complement activation (GO:0030449)3.83071358
68indolalkylamine metabolic process (GO:0006586)3.81426714
69uronic acid metabolic process (GO:0006063)3.80723431
70glucuronate metabolic process (GO:0019585)3.80723431
71cellular biogenic amine catabolic process (GO:0042402)3.79795457
72amine catabolic process (GO:0009310)3.79795457
73glycine metabolic process (GO:0006544)3.79406503
74cell adhesion mediated by integrin (GO:0033627)3.78962676
75triglyceride homeostasis (GO:0070328)3.78449651
76acylglycerol homeostasis (GO:0055090)3.78449651
77cellular modified amino acid catabolic process (GO:0042219)3.74811620
78very-low-density lipoprotein particle assembly (GO:0034379)3.74129963
79reverse cholesterol transport (GO:0043691)3.73190212
80bile acid and bile salt transport (GO:0015721)3.72359427
81drug transport (GO:0015893)3.72123643
82aspartate family amino acid catabolic process (GO:0009068)3.68997425
83acetyl-CoA metabolic process (GO:0006084)3.68693682
84intestinal cholesterol absorption (GO:0030299)3.64219873
85benzene-containing compound metabolic process (GO:0042537)3.63539456
86drug catabolic process (GO:0042737)3.61599151
87regulation of cholesterol esterification (GO:0010872)3.61158139
88plasma lipoprotein particle assembly (GO:0034377)3.57732608
89terpenoid biosynthetic process (GO:0016114)3.57578092
90negative regulation of cholesterol transport (GO:0032375)3.55227557
91negative regulation of sterol transport (GO:0032372)3.55227557
92imidazole-containing compound metabolic process (GO:0052803)3.52024530
93cholesterol efflux (GO:0033344)3.50636907
94* response to nitrosative stress (GO:0051409)3.49898509
95fatty acid oxidation (GO:0019395)3.49764537
96organic acid catabolic process (GO:0016054)3.48815086
97carboxylic acid catabolic process (GO:0046395)3.48815086
98heme metabolic process (GO:0042168)3.45791494
99carnitine metabolic process (GO:0009437)3.44337382
100lipid oxidation (GO:0034440)3.44130239
101nicotinamide nucleotide biosynthetic process (GO:0019359)3.44016659
102pyridine nucleotide biosynthetic process (GO:0019363)3.44016659
103blood coagulation, intrinsic pathway (GO:0007597)3.43369819
104ketone body metabolic process (GO:1902224)3.42968844
105protoporphyrinogen IX biosynthetic process (GO:0006782)3.42672265
106fatty acid beta-oxidation (GO:0006635)3.42514711
107response to mercury ion (GO:0046689)3.40876387
108valine metabolic process (GO:0006573)3.40048894
109phospholipid efflux (GO:0033700)3.39215274
110flavonoid metabolic process (GO:0009812)3.35793494
111fibrinolysis (GO:0042730)3.35612126
112cholesterol homeostasis (GO:0042632)3.33959355
113sterol homeostasis (GO:0055092)3.32255691
114response to arsenic-containing substance (GO:0046685)3.27680022
115nucleobase-containing small molecule interconversion (GO:0015949)3.15981492
116primary alcohol metabolic process (GO:0034308)3.14563737
117cellular aldehyde metabolic process (GO:0006081)3.14348405
118UDP-N-acetylglucosamine metabolic process (GO:0006047)3.07957213
119pyrimidine-containing compound transmembrane transport (GO:0072531)3.03699847
120retinoic acid metabolic process (GO:0042573)3.03517561
121macroautophagy (GO:0016236)3.00100190
122cyclooxygenase pathway (GO:0019371)2.94249678
123regulation of metalloenzyme activity (GO:0048552)2.93157251
124C21-steroid hormone metabolic process (GO:0008207)2.92089429
125xenobiotic catabolic process (GO:0042178)2.85590339
126retinol metabolic process (GO:0042572)2.81064235
127porphyrin-containing compound metabolic process (GO:0006778)2.74974879
128regulation of vitamin metabolic process (GO:0030656)2.72611553
129positive regulation of endothelial cell apoptotic process (GO:2000353)2.70294932
130cellular ketone metabolic process (GO:0042180)2.66484091
131pteridine-containing compound biosynthetic process (GO:0042559)2.66278476
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.65760168
133nucleotide-sugar biosynthetic process (GO:0009226)2.64522399
134ER overload response (GO:0006983)2.59998168
135hepatocyte differentiation (GO:0070365)2.59618720
136phenylpropanoid metabolic process (GO:0009698)2.58720155
137positive regulation of glycolytic process (GO:0045821)2.58366353
138cellular response to vitamin D (GO:0071305)2.56158076
139folic acid-containing compound biosynthetic process (GO:0009396)2.53924832
140L-ascorbic acid metabolic process (GO:0019852)2.53487959
141sphingoid metabolic process (GO:0046519)2.49668848
142COPII vesicle coating (GO:0048208)2.49204567
143porphyrin-containing compound biosynthetic process (GO:0006779)2.46517883
144regulation of early endosome to late endosome transport (GO:2000641)2.46317560
145cellular response to arsenic-containing substance (GO:0071243)2.46170261
146tetrahydrofolate metabolic process (GO:0046653)2.46066308
147exogenous drug catabolic process (GO:0042738)2.46009519
148regulation of integrin-mediated signaling pathway (GO:2001044)2.45098050
149hemoglobin metabolic process (GO:0020027)2.41163962
150intestinal absorption (GO:0050892)2.40869758
151axonemal dynein complex assembly (GO:0070286)2.40820521
152regulation of translational termination (GO:0006449)2.38939233
153androgen biosynthetic process (GO:0006702)2.38920353
154erythrocyte maturation (GO:0043249)2.38352818
155regulation of response to tumor cell (GO:0002834)2.38100088
156positive regulation of response to tumor cell (GO:0002836)2.38100088
157positive regulation of immune response to tumor cell (GO:0002839)2.38100088
158regulation of immune response to tumor cell (GO:0002837)2.38100088
159tetrapyrrole biosynthetic process (GO:0033014)2.37632197
160desmosome organization (GO:0002934)2.36256471
161positive regulation of protein autophosphorylation (GO:0031954)2.34761456
162sphingosine metabolic process (GO:0006670)2.34241269
163regulation of transforming growth factor beta1 production (GO:0032908)2.33226955
164negative regulation of hormone metabolic process (GO:0032351)2.32897759
165secondary metabolic process (GO:0019748)2.32575944
166magnesium ion transport (GO:0015693)2.31719316
167lung vasculature development (GO:0060426)2.29229185
168mesodermal cell differentiation (GO:0048333)2.28967708
169positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.28873805
170water-soluble vitamin biosynthetic process (GO:0042364)2.26454480
171hemidesmosome assembly (GO:0031581)2.25861346
172ethanol metabolic process (GO:0006067)2.21663442
173interleukin-6-mediated signaling pathway (GO:0070102)2.20284332
174renal absorption (GO:0070293)2.17459645
175polyketide metabolic process (GO:0030638)10.5407828
176doxorubicin metabolic process (GO:0044598)10.5407828
177daunorubicin metabolic process (GO:0044597)10.5407828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.32897987
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.28140669
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.04325594
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.62284696
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.99135894
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.55737475
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.36208553
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.96461335
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77879669
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.04669586
11GATA1_22025678_ChIP-Seq_K562_Human2.67251300
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39780028
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29202031
14E2F7_22180533_ChIP-Seq_HELA_Human2.17084202
15* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.16644140
16* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.16644140
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5727944
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96790897
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90411774
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85669226
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75514327
22CJUN_26792858_Chip-Seq_BT549_Human1.71813782
23ELK1_19687146_ChIP-ChIP_HELA_Human1.70352233
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.69203578
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61842561
26TFEB_21752829_ChIP-Seq_HELA_Human1.60196570
27GATA1_19941826_ChIP-Seq_K562_Human1.54989853
28* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50438147
29* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48446187
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.47799033
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47717775
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.47387957
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.47122431
34CLOCK_20551151_ChIP-Seq_293T_Human1.42791272
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.41933866
36DCP1A_22483619_ChIP-Seq_HELA_Human1.41079692
37* BRD4_25478319_ChIP-Seq_HGPS_Human1.40510406
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.39486116
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37514132
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36769474
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.36641814
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35322577
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35254300
44* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35126572
45JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31809954
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.27741250
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.27059020
48CDX2_22108803_ChIP-Seq_LS180_Human1.26575302
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25469395
50EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23926732
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.22872571
52* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21138796
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20719264
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20147374
55* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19258906
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19258664
57ATF3_27146783_Chip-Seq_COLON_Human1.19187210
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.18843283
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18352129
60ZNF263_19887448_ChIP-Seq_K562_Human1.17644389
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.16333762
62ELF5_23300383_ChIP-Seq_T47D_Human1.16119125
63TP63_23658742_ChIP-Seq_EP156T_Human1.15977127
64SCL_19346495_ChIP-Seq_HPC-7_Human1.14658135
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12174324
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11036357
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08528187
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08228653
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.07680907
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07450759
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06822290
72GATA4_25053715_ChIP-Seq_YYC3_Human1.06670152
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.06387225
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06364190
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05876737
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.03753984
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.03284690
78GATA2_19941826_ChIP-Seq_K562_Human1.03106663
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.02346400
80HTT_18923047_ChIP-ChIP_STHdh_Human1.01309389
81* HNFA_21074721_ChIP-Seq_CACO-2_Human1.00798174
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00056976
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99735579
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99479294
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99469987
86TP53_18474530_ChIP-ChIP_U2OS_Human0.99428116
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99220769
88* PHF8_20622853_ChIP-Seq_HELA_Human0.98688028
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97049553
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96337792
91* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95276957
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92784939
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91284860
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90838328
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90324089
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89876563
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89649718
98RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88578301
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87662417
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87170454
101* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86875463
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86527805
103TP53_16413492_ChIP-PET_HCT116_Human0.86344773
104* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86010881
105* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86010881
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85105003
107* CHD1_26751641_Chip-Seq_LNCaP_Human0.84796378
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82633941
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81965569
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81539767
111IRF8_27001747_Chip-Seq_BMDM_Mouse0.81134455
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81050754
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80838553
114GATA6_25053715_ChIP-Seq_YYC3_Human0.78910481
115EGR1_19032775_ChIP-ChIP_M12_Human0.77560599
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.77092154
117KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.76519959
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76235735
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.75565877
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74824087
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73472578
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72761051
123IRF8_21731497_ChIP-ChIP_J774_Mouse0.72002757
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.71840165
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71391874
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69085170
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.68963842
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68225351
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67880544
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67021559
131MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.65502168
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.64724859
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.62609176
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60748565
135* SOX2_20726797_ChIP-Seq_SW620_Human0.60456159
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.60222752
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59293497
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58482371
139AR_21909140_ChIP-Seq_LNCAP_Human0.56994595
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.56639214
141SRF_21415370_ChIP-Seq_HL-1_Mouse0.56148832
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55944583
143AR_20517297_ChIP-Seq_VCAP_Human0.54184137
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.54120770
145RACK7_27058665_Chip-Seq_MCF-7_Human0.54081934
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.52762772
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52489983
148IRF1_19129219_ChIP-ChIP_H3396_Human0.51962116
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.51873825
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.50688224
151E2F1_18555785_ChIP-Seq_MESCs_Mouse0.50639595
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.50048489
153* MYC_19915707_ChIP-ChIP_AK7_Human0.49637680
154LXR_22292898_ChIP-Seq_THP-1_Human0.48495532
155NANOG_20526341_ChIP-Seq_ESCs_Human0.48407764
156BCOR_27268052_Chip-Seq_Bcells_Human0.48359294
157* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48329635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50814039
2MP0005360_urolithiasis6.93768441
3MP0005085_abnormal_gallbladder_physiolo5.29011071
4MP0005365_abnormal_bile_salt5.15129714
5MP0003806_abnormal_nucleotide_metabolis4.74976432
6MP0008875_abnormal_xenobiotic_pharmacok4.56250410
7MP0003195_calcinosis3.67355048
8MP0003950_abnormal_plasma_membrane3.64837603
9MP0003656_abnormal_erythrocyte_physiolo3.32715374
10MP0003252_abnormal_bile_duct3.27117079
11MP0010352_gastrointestinal_tract_polyps3.12392041
12MP0009780_abnormal_chondrocyte_physiolo3.08323850
13MP0005083_abnormal_biliary_tract2.97108513
14* MP0005332_abnormal_amino_acid2.90344570
15MP0002877_abnormal_melanocyte_morpholog2.88484894
16MP0010329_abnormal_lipoprotein_level2.82393997
17MP0009840_abnormal_foam_cell2.77004596
18MP0010234_abnormal_vibrissa_follicle2.66016033
19MP0006054_spinal_hemorrhage2.52425379
20MP0001666_abnormal_nutrient_absorption2.39486884
21MP0004019_abnormal_vitamin_homeostasis2.25441230
22MP0002138_abnormal_hepatobiliary_system2.23824535
23MP0003191_abnormal_cellular_cholesterol2.17332958
24MP0004147_increased_porphyrin_level2.12351388
25* MP0003186_abnormal_redox_activity2.07694897
26MP0000609_abnormal_liver_physiology1.96723929
27MP0002118_abnormal_lipid_homeostasis1.95342237
28MP0003566_abnormal_cell_adhesion1.78781222
29MP0009643_abnormal_urine_homeostasis1.77279050
30MP0005584_abnormal_enzyme/coenzyme_acti1.74288159
31* MP0005319_abnormal_enzyme/_coenzyme1.74116760
32MP0008438_abnormal_cutaneous_collagen1.71403965
33MP0010678_abnormal_skin_adnexa1.68583779
34MP0003868_abnormal_feces_composition1.67846622
35MP0005636_abnormal_mineral_homeostasis1.65133052
36MP0002837_dystrophic_cardiac_calcinosis1.63192773
37MP0004043_abnormal_pH_regulation1.61345905
38MP0003724_increased_susceptibility_to1.54877933
39MP0001764_abnormal_homeostasis1.53606381
40MP0004272_abnormal_basement_membrane1.53259175
41MP0003941_abnormal_skin_development1.52273764
42MP0005058_abnormal_lysosome_morphology1.47051114
43MP0005023_abnormal_wound_healing1.43657754
44MP0000013_abnormal_adipose_tissue1.42588104
45MP0003453_abnormal_keratinocyte_physiol1.40104581
46MP0005451_abnormal_body_composition1.34363000
47MP0006036_abnormal_mitochondrial_physio1.33732730
48MP0009764_decreased_sensitivity_to1.28408984
49MP0005165_increased_susceptibility_to1.25562666
50MP0002060_abnormal_skin_morphology1.24962478
51MP0000604_amyloidosis1.24455390
52MP0008007_abnormal_cellular_replicative1.21343390
53MP0005623_abnormal_meninges_morphology1.20262307
54MP0003690_abnormal_glial_cell1.20248432
55MP0000598_abnormal_liver_morphology1.19131090
56MP0004233_abnormal_muscle_weight1.18908870
57MP0008775_abnormal_heart_ventricle1.17457173
58MP0000383_abnormal_hair_follicle1.13276391
59* MP0008469_abnormal_protein_level1.10434988
60MP0003786_premature_aging1.06482959
61MP0002163_abnormal_gland_morphology1.05801146
62MP0005379_endocrine/exocrine_gland_phen1.01324967
63MP0000427_abnormal_hair_cycle1.00087597
64* MP0009763_increased_sensitivity_to0.99845428
65MP0002168_other_aberrant_phenotype0.99552852
66MP0001944_abnormal_pancreas_morphology0.97030803
67MP0002332_abnormal_exercise_endurance0.96051889
68MP0005084_abnormal_gallbladder_morpholo0.94076680
69MP0001756_abnormal_urination0.93678639
70MP0004215_abnormal_myocardial_fiber0.93207448
71MP0004957_abnormal_blastocyst_morpholog0.92477435
72MP0004084_abnormal_cardiac_muscle0.92258536
73MP0001216_abnormal_epidermal_layer0.92163669
74MP0005464_abnormal_platelet_physiology0.91765116
75MP0002693_abnormal_pancreas_physiology0.91716860
76MP0000920_abnormal_myelination0.91489866
77MP0003329_amyloid_beta_deposits0.90883322
78MP0009697_abnormal_copulation0.90695318
79MP0005535_abnormal_body_temperature0.89065774
80MP0006082_CNS_inflammation0.87598859
81* MP0009642_abnormal_blood_homeostasis0.86986260
82MP0005376_homeostasis/metabolism_phenot0.86829064
83MP0002136_abnormal_kidney_physiology0.86020909
84MP0000358_abnormal_cell_content/0.84142365
85MP0003045_fibrosis0.83788476
86MP0004130_abnormal_muscle_cell0.82561745
87MP0003300_gastrointestinal_ulcer0.81845828
88MP0001243_abnormal_dermal_layer0.81542614
89MP0005408_hypopigmentation0.80281033
90MP0005647_abnormal_sex_gland0.79707596
91MP0002971_abnormal_brown_adipose0.79594516
92MP0001661_extended_life_span0.78824988
93* MP0009765_abnormal_xenobiotic_induced0.77577063
94MP0002078_abnormal_glucose_homeostasis0.77222359
95MP0002295_abnormal_pulmonary_circulatio0.77053387
96MP0005266_abnormal_metabolism0.76450035
97MP0002896_abnormal_bone_mineralization0.76216887
98MP0005220_abnormal_exocrine_pancreas0.74135792
99MP0003011_delayed_dark_adaptation0.74088478
100MP0001915_intracranial_hemorrhage0.73627417
101MP0000647_abnormal_sebaceous_gland0.73214675
102MP0000003_abnormal_adipose_tissue0.73080556
103MP0001191_abnormal_skin_condition0.72369847
104MP0001765_abnormal_ion_homeostasis0.71156219
105MP0008004_abnormal_stomach_pH0.70582302
106MP0005670_abnormal_white_adipose0.70493854
107MP0006035_abnormal_mitochondrial_morpho0.70250743
108MP0003436_decreased_susceptibility_to0.69085334
109MP0010771_integument_phenotype0.68558895
110MP0005330_cardiomyopathy0.67383523
111MP0005666_abnormal_adipose_tissue0.65924648
112MP0005334_abnormal_fat_pad0.65880863
113MP0005501_abnormal_skin_physiology0.64335169
114MP0005410_abnormal_fertilization0.62591362
115MP0003303_peritoneal_inflammation0.62552203
116MP0003075_altered_response_to0.61954283
117MP0002972_abnormal_cardiac_muscle0.59620010
118MP0001299_abnormal_eye_distance/0.59011243
119MP0004036_abnormal_muscle_relaxation0.58901198
120MP0004185_abnormal_adipocyte_glucose0.56174116
121MP0001845_abnormal_inflammatory_respons0.54588074
122MP0003638_abnormal_response/metabolism_0.54085150
123* MP0008873_increased_physiological_sensi0.53532732
124MP0009785_altered_susceptibility_to0.52863328
125MP0003172_abnormal_lysosome_physiology0.49381072
126MP0002419_abnormal_innate_immunity0.48033633
127MP0002254_reproductive_system_inflammat0.46964625
128MP0005025_abnormal_response_to0.46936538
129MP0002876_abnormal_thyroid_physiology0.45532047
130MP0005164_abnormal_response_to0.45306893
131MP0005395_other_phenotype0.44127530
132MP0010368_abnormal_lymphatic_system0.43695644
133MP0005166_decreased_susceptibility_to0.43450653
134MP0000230_abnormal_systemic_arterial0.41537156
135MP0000639_abnormal_adrenal_gland0.41498483
136MP0005397_hematopoietic_system_phenotyp0.41224483
137MP0001545_abnormal_hematopoietic_system0.41224483
138MP0003718_maternal_effect0.41160441
139MP0008874_decreased_physiological_sensi0.41145130
140MP0002928_abnormal_bile_duct0.40804841
141MP0002970_abnormal_white_adipose0.40083343
142MP0005448_abnormal_energy_balance0.40047009
143MP0003705_abnormal_hypodermis_morpholog0.39350155
144MP0004142_abnormal_muscle_tone0.38097276
145MP0000343_altered_response_to0.36262285
146MP0003953_abnormal_hormone_level0.35595936
147MP0005167_abnormal_blood-brain_barrier0.35243258
148MP0001853_heart_inflammation0.34103619
149MP0001533_abnormal_skeleton_physiology0.33354451
150MP0004264_abnormal_extraembryonic_tissu0.32556813
151MP0001881_abnormal_mammary_gland0.32073206

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.52517245
2Intrahepatic cholestasis (HP:0001406)6.18659721
3Xanthomatosis (HP:0000991)5.34408127
4Deep venous thrombosis (HP:0002625)5.26366136
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.25899267
6Prolonged partial thromboplastin time (HP:0003645)4.67973351
7Hypobetalipoproteinemia (HP:0003563)4.63224847
8Hyperlipoproteinemia (HP:0010980)4.57160955
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12937201
10Hyperkalemia (HP:0002153)4.12237537
11Hyperammonemia (HP:0001987)3.97557152
12Complement deficiency (HP:0004431)3.91772587
13Abnormality of aspartate family amino acid metabolism (HP:0010899)3.86991658
14Ketosis (HP:0001946)3.85905939
15Nuclear cataract (HP:0100018)3.75959843
16Fat malabsorption (HP:0002630)3.72153283
17Hypoglycemic coma (HP:0001325)3.70833508
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.70394910
19Increased circulating renin level (HP:0000848)3.68248506
20Joint hemorrhage (HP:0005261)3.64979998
21Hyperbilirubinemia (HP:0002904)3.64016610
22Abnormality of glycine metabolism (HP:0010895)3.61903936
23Abnormality of serine family amino acid metabolism (HP:0010894)3.61903936
24Epidermoid cyst (HP:0200040)3.60693027
25Hyperglycinuria (HP:0003108)3.59204690
26Hyperglycinemia (HP:0002154)3.58115554
27Absent/shortened dynein arms (HP:0200106)3.51785890
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.51785890
29Abnormality of the common coagulation pathway (HP:0010990)3.48124534
30Acanthocytosis (HP:0001927)3.44772716
31Hypolipoproteinemia (HP:0010981)3.43870613
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.42747537
33Hyperactive renin-angiotensin system (HP:0000841)3.37224156
34Abnormality of methionine metabolism (HP:0010901)3.35369364
35Abnormality of fatty-acid metabolism (HP:0004359)3.29624870
36Poikilocytosis (HP:0004447)3.23727232
37Abnormality of the heme biosynthetic pathway (HP:0010472)3.22141037
38Conjugated hyperbilirubinemia (HP:0002908)3.13473241
39Decreased circulating renin level (HP:0003351)3.11781816
40Abnormality of purine metabolism (HP:0004352)3.08984221
41Ketoacidosis (HP:0001993)3.04500753
42Gout (HP:0001997)3.00464591
43Steatorrhea (HP:0002570)3.00385856
44Abnormality of nucleobase metabolism (HP:0010932)2.98797987
45Tetraparesis (HP:0002273)2.98484458
46Abnormality of complement system (HP:0005339)2.97672053
47Hypercholesterolemia (HP:0003124)2.95907999
48Abnormal respiratory epithelium morphology (HP:0012253)2.94008755
49Abnormal respiratory motile cilium morphology (HP:0005938)2.94008755
50Hypoalphalipoproteinemia (HP:0003233)2.93880531
51Abnormality of the intrinsic pathway (HP:0010989)2.93600962
52Toxemia of pregnancy (HP:0100603)2.91315655
53Generalized aminoaciduria (HP:0002909)2.89525915
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88062389
55Hypochromic microcytic anemia (HP:0004840)2.86718848
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.83762969
57Rhinitis (HP:0012384)2.81272073
58Abnormality of pyrimidine metabolism (HP:0004353)2.78425519
59Abnormal ciliary motility (HP:0012262)2.78262810
60Abnormality of serum amino acid levels (HP:0003112)2.76980739
61Delayed CNS myelination (HP:0002188)2.75801446
62Metabolic acidosis (HP:0001942)2.75060826
63Abnormal respiratory motile cilium physiology (HP:0012261)2.74937272
64Abnormal gallbladder morphology (HP:0012437)2.73427886
65Cholelithiasis (HP:0001081)2.67784043
66Proximal tubulopathy (HP:0000114)2.67302555
67Hyponatremia (HP:0002902)2.66898752
68Hepatocellular carcinoma (HP:0001402)2.64806699
69Lethargy (HP:0001254)2.63913512
70Dicarboxylic aciduria (HP:0003215)2.63774167
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63774167
72Vascular calcification (HP:0004934)2.59715699
73Reticulocytosis (HP:0001923)2.56778310
74Myocardial infarction (HP:0001658)2.54991831
75Abnormality of iron homeostasis (HP:0011031)2.53144178
76Cerebral edema (HP:0002181)2.52813082
77Mitral stenosis (HP:0001718)2.51875036
78Cholecystitis (HP:0001082)2.50798342
79Abnormal gallbladder physiology (HP:0012438)2.50798342
80Recurrent gram-negative bacterial infections (HP:0005420)2.49490874
81Nausea (HP:0002018)2.49141612
82Increased serum ferritin (HP:0003281)2.48247458
83Abnormality of transition element cation homeostasis (HP:0011030)2.48142477
84Alkalosis (HP:0001948)2.44507141
85Hypokinesia (HP:0002375)2.42919131
86Vomiting (HP:0002013)2.36442452
87Premature rupture of membranes (HP:0001788)2.34980211
88Glycosuria (HP:0003076)2.32972470
89Abnormality of urine glucose concentration (HP:0011016)2.32972470
90Rickets (HP:0002748)2.32906945
91Irritability (HP:0000737)2.32872770
92Hypoglycemic seizures (HP:0002173)2.30873835
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29422793
94Sensorimotor neuropathy (HP:0007141)2.28783048
95Back pain (HP:0003418)2.28342880
96Spastic diplegia (HP:0001264)2.26453511
97Pancreatitis (HP:0001733)2.25252217
98Hydroxyprolinuria (HP:0003080)2.22734669
99Abnormality of proline metabolism (HP:0010907)2.22734669
100Severe visual impairment (HP:0001141)2.22532816
101Increased purine levels (HP:0004368)2.21116726
102Hyperuricemia (HP:0002149)2.21116726
103Cardiovascular calcification (HP:0011915)2.19712092
104Abnormality of the gallbladder (HP:0005264)2.18907245
105Axonal loss (HP:0003447)2.18733386
106Biliary tract neoplasm (HP:0100574)2.18512677
107Congenital cataract (HP:0000519)2.16766346
108Ileus (HP:0002595)2.16763071
109Osteolytic defects of the hand bones (HP:0009699)2.15881127
110Osteolytic defects of the phalanges of the hand (HP:0009771)2.15881127
111Rectal prolapse (HP:0002035)2.15076739
112Menorrhagia (HP:0000132)2.15076010
113Brushfield spots (HP:0001088)2.14732228
114Systemic lupus erythematosus (HP:0002725)2.14593201
115Skin nodule (HP:0200036)2.14179955
116Paralysis (HP:0003470)2.13859639
117Abnormal biliary tract morphology (HP:0012440)2.11485789
118Short nail (HP:0001799)2.11260681
119Opisthotonus (HP:0002179)2.08957879
120Hyperthyroidism (HP:0000836)2.06706345
121Abnormal enzyme/coenzyme activity (HP:0012379)2.05641445
122Progressive hearing impairment (HP:0001730)2.05252775
123Metaphyseal dysplasia (HP:0100255)2.03831812
124Palpitations (HP:0001962)2.03148679
125Spontaneous abortion (HP:0005268)2.02785200
126Vacuolated lymphocytes (HP:0001922)2.02565926
127Amyloidosis (HP:0011034)2.02270364
128Hyperglycemia (HP:0003074)2.01615489
129Spastic paraparesis (HP:0002313)2.01420803
130Abnormality of sodium homeostasis (HP:0010931)1.99760671
131Increased mean platelet volume (HP:0011877)1.99345734
132Hyperphosphatemia (HP:0002905)1.98522085
133Malnutrition (HP:0004395)1.98342046
134Abnormal hemoglobin (HP:0011902)1.97976933
135Gingival bleeding (HP:0000225)1.97703493
136Abnormality of chloride homeostasis (HP:0011422)1.97561671
137Unilateral renal agenesis (HP:0000122)1.94808770
138Azoospermia (HP:0000027)1.93409945
139Sex reversal (HP:0012245)1.93150703
140Abnormal sex determination (HP:0012244)1.93150703
141Hematochezia (HP:0002573)1.91984709
142Polycythemia (HP:0001901)1.91044434
143Confusion (HP:0001289)1.90755471
144Hypokalemic alkalosis (HP:0001949)1.90715347
145Hyperphosphaturia (HP:0003109)1.90352105
146Zonular cataract (HP:0010920)1.90217820
147Late onset (HP:0003584)1.89374892
148Central scotoma (HP:0000603)1.88425806
149Abnormality of vitamin metabolism (HP:0100508)1.87078300
150Upper limb muscle weakness (HP:0003484)1.85605734
151Fair hair (HP:0002286)1.84327159
152Abnormality of potassium homeostasis (HP:0011042)1.82856860
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81646646
154Abnormality of alanine metabolism (HP:0010916)1.81646646
155Hyperalaninemia (HP:0003348)1.81646646
156Follicular hyperkeratosis (HP:0007502)1.80864234
157Male infertility (HP:0003251)1.78082598
158Hypoplasia of the uterus (HP:0000013)1.77222097
159Symptomatic seizures (HP:0011145)1.71713724
160Renal cortical cysts (HP:0000803)1.71214001
161Neoplasm of the rectum (HP:0100743)1.71126213
162Abnormality of macular pigmentation (HP:0008002)1.67233682
163Progressive muscle weakness (HP:0003323)1.66045365
164Bronchiectasis (HP:0002110)1.65949699
165Chronic bronchitis (HP:0004469)1.65246472
166Hyperaldosteronism (HP:0000859)1.65031022
167Abnormality of renin-angiotensin system (HP:0000847)1.64072318
168Onycholysis (HP:0001806)1.62459883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.40460675
2PBK3.75495338
3OXSR13.29122281
4TAOK33.19695060
5WNK43.08443005
6STK393.01808660
7NME22.90120100
8ERN12.89937015
9ERBB42.80501561
10EIF2AK12.69029686
11BRSK22.27777916
12ABL22.23626860
13EPHB12.22314104
14EPHA22.05989456
15WNK32.01842686
16FGFR41.97296570
17MST1R1.95010595
18IRAK31.94147648
19NEK11.88911142
20SIK11.87320594
21MAP3K111.78572766
22TBK11.72293972
23LMTK21.66969029
24MAP2K61.64299155
25MAP3K121.60046950
26BUB11.53926790
27MET1.53319442
28PINK11.51157995
29MAPK151.48669259
30TTK1.47055978
31PIM21.44990095
32MAPK111.40360594
33INSRR1.35521883
34JAK21.30412560
35TAOK21.25378531
36ACVR1B1.24091742
37SCYL21.22513416
38CLK11.22302576
39MAPKAPK51.16501929
40MAP2K21.11427597
41CSK1.11282768
42TYK21.10627245
43NEK91.09693811
44MST41.08288896
45TESK21.08088970
46MYLK1.07890350
47CDK81.06949665
48MAPKAPK31.06612254
49ADRBK21.04786637
50ERBB31.03223158
51STK161.03122239
52TSSK61.01659300
53BMX1.01338263
54PIK3CG0.99115497
55LATS20.98964507
56PTK2B0.96290425
57PHKG10.94815649
58PHKG20.94815649
59LATS10.93702704
60PAK40.92678355
61KDR0.91507918
62ZAK0.90002401
63IRAK10.89400261
64PDK20.89286418
65CDK60.87685904
66WEE10.87509993
67FLT30.87204457
68MAP3K20.87124812
69DYRK1B0.87081054
70FER0.84966298
71PASK0.84642561
72PRKCI0.84507823
73CDK190.83640654
74GRK10.83334025
75MAP3K140.82149314
76BMPR20.80573683
77TRIB30.79469419
78PLK30.79234895
79KSR20.77192281
80PLK20.76374020
81PTK60.75629401
82MELK0.75000173
83MAP2K40.74855757
84IRAK40.74347660
85PRKAA20.73936527
86MAP3K10.72000088
87CAMKK20.71623476
88MAPK40.71270133
89STK40.71211142
90GSK3A0.70788763
91CSNK1G30.70501188
92PDPK10.69478014
93TEC0.68411449
94BLK0.67703057
95PLK10.66126882
96ERBB20.65973864
97CSNK1G10.65884695
98IKBKE0.65864698
99PNCK0.64496090
100IRAK20.64160005
101MAP3K130.63673155
102CAMK2G0.63630568
103STK240.62650638
104TTN0.61493695
105TLK10.61118207
106MATK0.61102546
107PIM10.59877745
108MAP3K80.59232701
109STK38L0.57121917
110MAP2K10.55889725
111GRK60.54388723
112LRRK20.52595185
113PRKACG0.52007548
114MAP3K90.51151390
115EGFR0.51066906
116MAP2K30.50748158
117PRKCE0.50487871
118STK100.50115411
119EIF2AK30.49285905
120MAP3K30.49041664
121IKBKB0.48949127
122ABL10.48935921
123NTRK10.48092907
124STK30.47376109
125ICK0.46950160
126CSNK1G20.46499680
127FGR0.45655923
128BRSK10.44865443
129TIE10.44665105
130CHEK20.44347007
131PRKG20.44058004
132PTK20.43171405
133EIF2AK20.42950718
134LYN0.42556278
135KIT0.42181831
136ARAF0.40295451
137PRKCD0.40244135
138AKT20.39896081
139PRKCQ0.39849354
140STK380.39534806
141FRK0.39479489
142PRKCZ0.38912549
143WNK10.38044728
144ADRBK10.35370066
145CSNK1A1L0.34899609
146CAMK2D0.34891947
147CHEK10.34661038
148LIMK10.33872596
149KSR10.33622396
150BRAF0.33553394
151DYRK30.33279341
152PKN20.33102848
153TRPM70.32486057
154DAPK20.31710946
155GRK70.31136535
156BMPR1B0.30303022
157NEK20.29435589
158CASK0.29411316
159HIPK20.29392082
160RPS6KB20.28711352

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.85756731
2Nitrogen metabolism_Homo sapiens_hsa009103.46123354
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24565706
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68513179
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61652388
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57847053
7Arginine biosynthesis_Homo sapiens_hsa002202.49768598
8Tryptophan metabolism_Homo sapiens_hsa003802.48399759
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46069431
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45651466
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39355339
12Fatty acid degradation_Homo sapiens_hsa000712.31506542
13Peroxisome_Homo sapiens_hsa041462.28808924
14Complement and coagulation cascades_Homo sapiens_hsa046102.22601886
15Butanoate metabolism_Homo sapiens_hsa006502.21755893
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08677660
17Propanoate metabolism_Homo sapiens_hsa006402.07815853
18Histidine metabolism_Homo sapiens_hsa003401.98589064
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.97453735
20Sulfur metabolism_Homo sapiens_hsa009201.94998556
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91339806
22Folate biosynthesis_Homo sapiens_hsa007901.83771720
23PPAR signaling pathway_Homo sapiens_hsa033201.83499382
24Chemical carcinogenesis_Homo sapiens_hsa052041.80783358
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79497708
26Selenocompound metabolism_Homo sapiens_hsa004501.76222293
27beta-Alanine metabolism_Homo sapiens_hsa004101.75580841
28Fatty acid metabolism_Homo sapiens_hsa012121.69081634
29Steroid biosynthesis_Homo sapiens_hsa001001.63339900
30Fatty acid elongation_Homo sapiens_hsa000621.62630879
31Caffeine metabolism_Homo sapiens_hsa002321.62614660
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.61087424
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56477654
34Staphylococcus aureus infection_Homo sapiens_hsa051501.54799949
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.52617814
36Pyruvate metabolism_Homo sapiens_hsa006201.49011100
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46709596
38Sulfur relay system_Homo sapiens_hsa041221.45259340
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43890598
40Retinol metabolism_Homo sapiens_hsa008301.43255420
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43053130
42Bile secretion_Homo sapiens_hsa049761.42135498
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39321676
44Phenylalanine metabolism_Homo sapiens_hsa003601.29005372
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25069386
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20895612
47* Cysteine and methionine metabolism_Homo sapiens_hsa002701.20347414
48ABC transporters_Homo sapiens_hsa020101.19508508
49Starch and sucrose metabolism_Homo sapiens_hsa005001.18077044
50Tyrosine metabolism_Homo sapiens_hsa003501.17579557
51Arginine and proline metabolism_Homo sapiens_hsa003301.16330439
52Circadian rhythm_Homo sapiens_hsa047101.16280594
53* Glutathione metabolism_Homo sapiens_hsa004801.15315610
54Carbon metabolism_Homo sapiens_hsa012001.14868980
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13404140
56Sphingolipid metabolism_Homo sapiens_hsa006001.13066436
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.12958946
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12021670
59Vitamin digestion and absorption_Homo sapiens_hsa049771.08699216
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.08201928
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07143977
62Fat digestion and absorption_Homo sapiens_hsa049751.06537979
63Biosynthesis of amino acids_Homo sapiens_hsa012301.05766167
64Vitamin B6 metabolism_Homo sapiens_hsa007501.04427093
65Proteasome_Homo sapiens_hsa030500.94614468
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87834593
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84377691
68Pentose phosphate pathway_Homo sapiens_hsa000300.75412096
69Basal transcription factors_Homo sapiens_hsa030220.74207834
70Glycerolipid metabolism_Homo sapiens_hsa005610.73969622
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73114262
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72541549
73One carbon pool by folate_Homo sapiens_hsa006700.71313527
74N-Glycan biosynthesis_Homo sapiens_hsa005100.67333777
75* Metabolic pathways_Homo sapiens_hsa011000.60438323
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56299392
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54154959
78ECM-receptor interaction_Homo sapiens_hsa045120.52495084
79Lysine degradation_Homo sapiens_hsa003100.52075299
80Nucleotide excision repair_Homo sapiens_hsa034200.51650281
81Pyrimidine metabolism_Homo sapiens_hsa002400.51534285
82p53 signaling pathway_Homo sapiens_hsa041150.43851915
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42673281
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41626291
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40156665
86TGF-beta signaling pathway_Homo sapiens_hsa043500.39513479
87Collecting duct acid secretion_Homo sapiens_hsa049660.38254912
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38168113
89Fatty acid biosynthesis_Homo sapiens_hsa000610.36668260
90Small cell lung cancer_Homo sapiens_hsa052220.34912422
91Linoleic acid metabolism_Homo sapiens_hsa005910.34582738
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33902604
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33372876
94Purine metabolism_Homo sapiens_hsa002300.28512015
95Oxidative phosphorylation_Homo sapiens_hsa001900.28465200
96Prion diseases_Homo sapiens_hsa050200.27683661
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25941227
98TNF signaling pathway_Homo sapiens_hsa046680.25890639
99Shigellosis_Homo sapiens_hsa051310.25617380
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.25436534
101Adherens junction_Homo sapiens_hsa045200.25394743
102Lysosome_Homo sapiens_hsa041420.24119006
103Fructose and mannose metabolism_Homo sapiens_hsa000510.22826313
104Protein export_Homo sapiens_hsa030600.21729408
105Legionellosis_Homo sapiens_hsa051340.20235090
106Parkinsons disease_Homo sapiens_hsa050120.16487673
107Galactose metabolism_Homo sapiens_hsa000520.15493545
108Mineral absorption_Homo sapiens_hsa049780.14650368
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.14525884
110Ether lipid metabolism_Homo sapiens_hsa005650.12017110
111Systemic lupus erythematosus_Homo sapiens_hsa053220.07689253
112Malaria_Homo sapiens_hsa051440.07166726
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05387959
114Arachidonic acid metabolism_Homo sapiens_hsa005900.04321338
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03968460
116Insulin resistance_Homo sapiens_hsa049310.03654254
117Alzheimers disease_Homo sapiens_hsa050100.02279464
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01009221
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.00694719
120Regulation of autophagy_Homo sapiens_hsa04140-0.1262616
121Huntingtons disease_Homo sapiens_hsa05016-0.1210004
122Pertussis_Homo sapiens_hsa05133-0.0970086
123Bladder cancer_Homo sapiens_hsa05219-0.0861648
124Other glycan degradation_Homo sapiens_hsa00511-0.0639140
125AMPK signaling pathway_Homo sapiens_hsa04152-0.0468676
126Hepatitis C_Homo sapiens_hsa05160-0.0239712
127Renin-angiotensin system_Homo sapiens_hsa04614-0.0174832

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »