GCM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mature B cell differentiation involved in immune response (GO:0002313)7.06438592
2spindle assembly involved in mitosis (GO:0090307)6.81834615
3mesenchymal cell differentiation involved in kidney development (GO:0072161)6.24242398
4mesenchymal cell differentiation involved in renal system development (GO:2001012)6.24242398
5regulation of cell proliferation involved in kidney development (GO:1901722)6.23815407
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.21468507
7mature B cell differentiation (GO:0002335)6.17010102
8DNA deamination (GO:0045006)5.98312342
9glucosamine-containing compound catabolic process (GO:1901072)5.86436281
10prostate gland growth (GO:0060736)5.83025279
11sulfation (GO:0051923)5.51535147
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.43813121
13NADH dehydrogenase complex assembly (GO:0010257)5.43813121
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.43813121
15anterior/posterior axis specification, embryo (GO:0008595)5.38438241
16lung-associated mesenchyme development (GO:0060484)5.28344750
17negative regulation of Rho protein signal transduction (GO:0035024)5.14320824
18microtubule cytoskeleton organization involved in mitosis (GO:1902850)5.12508190
19response to lipoprotein particle (GO:0055094)4.97411379
20T-helper 1 type immune response (GO:0042088)4.89632317
21* branching involved in labyrinthine layer morphogenesis (GO:0060670)4.88288853
22mitochondrion morphogenesis (GO:0070584)4.87354655
23superoxide anion generation (GO:0042554)4.79833228
24negative regulation of telomerase activity (GO:0051974)4.76638984
25positive regulation of fatty acid oxidation (GO:0046321)4.67517095
26germinal center formation (GO:0002467)4.59962425
27centrosome duplication (GO:0051298)4.57805127
28positive regulation of mitochondrial fission (GO:0090141)4.54515166
29regulation of inositol phosphate biosynthetic process (GO:0010919)4.46659919
30regulation of tight junction assembly (GO:2000810)4.44653157
31regulation of sequestering of triglyceride (GO:0010889)4.41026676
32synapsis (GO:0007129)4.37282771
33purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.28210015
343-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.28210015
35positive regulation of oligodendrocyte differentiation (GO:0048714)4.25088216
36protein complex biogenesis (GO:0070271)4.13067077
37flavonoid metabolic process (GO:0009812)3.97821261
38negative regulation of systemic arterial blood pressure (GO:0003085)3.96341863
39amino sugar catabolic process (GO:0046348)3.94883983
40serine family amino acid catabolic process (GO:0009071)3.92712568
41positive regulation of cAMP-mediated signaling (GO:0043950)3.91372649
42cerebral cortex radially oriented cell migration (GO:0021799)3.91063051
43negative regulation of kidney development (GO:0090185)3.89209886
44regulation of energy homeostasis (GO:2000505)3.87556616
45mitochondrial respiratory chain complex assembly (GO:0033108)3.85297583
46negative regulation of mast cell activation (GO:0033004)3.84785905
47behavioral response to nicotine (GO:0035095)3.81727027
48cellular response to lithium ion (GO:0071285)3.81602412
49somite development (GO:0061053)3.80036892
50regulation of telomerase activity (GO:0051972)3.71416489
51regulation of synapse maturation (GO:0090128)3.70465958
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.69138117
53white fat cell differentiation (GO:0050872)3.69135838
54keratinocyte development (GO:0003334)3.67773880
55positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.67187719
56histamine secretion (GO:0001821)3.67144656
57daunorubicin metabolic process (GO:0044597)3.66723284
58polyketide metabolic process (GO:0030638)3.66723284
59doxorubicin metabolic process (GO:0044598)3.66723284
60microtubule depolymerization (GO:0007019)3.65626974
61preassembly of GPI anchor in ER membrane (GO:0016254)3.62860059
62righting reflex (GO:0060013)3.61010582
63positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.59473345
64energy homeostasis (GO:0097009)3.58756891
65regulation of heat generation (GO:0031650)3.58499311
66peripheral nervous system axon ensheathment (GO:0032292)3.54475668
67myelination in peripheral nervous system (GO:0022011)3.54475668
68epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.47492352
69cellular response to ATP (GO:0071318)3.46964186
70peroxisome fission (GO:0016559)3.44021050
71negative regulation of acute inflammatory response (GO:0002674)3.42608672
72kinetochore assembly (GO:0051382)3.41646140
73water-soluble vitamin biosynthetic process (GO:0042364)3.38034952
74cellular response to gamma radiation (GO:0071480)3.35688624
75inner cell mass cell proliferation (GO:0001833)3.34487121
76estrogen metabolic process (GO:0008210)3.34342756
77ventricular septum development (GO:0003281)3.34285202
78mitochondrial fusion (GO:0008053)3.33960716
79protein kinase C signaling (GO:0070528)3.33553184
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.33135203
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.32425460
82regulation of collateral sprouting (GO:0048670)3.32206754
83positive regulation of interleukin-10 production (GO:0032733)3.29564253
84pharyngeal system development (GO:0060037)3.29000875
85T cell lineage commitment (GO:0002360)3.28798056
86regulation of glomerulus development (GO:0090192)3.28127471
87CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.27745017
88T-helper cell differentiation (GO:0042093)3.27745017
89gland morphogenesis (GO:0022612)3.25467640
90regulation of mitochondrial fission (GO:0090140)3.25322139
91glycine metabolic process (GO:0006544)3.23215704
92immunoglobulin mediated immune response (GO:0016064)3.21302483
93facial nerve structural organization (GO:0021612)3.19472600
94defense response to protozoan (GO:0042832)3.17915841
95response to caffeine (GO:0031000)3.16351039
96spinal cord development (GO:0021510)3.16201449
97positive regulation of meiotic cell cycle (GO:0051446)3.16002314
98bone trabecula formation (GO:0060346)3.14875542
99cell proliferation in forebrain (GO:0021846)3.14396642
100B cell activation involved in immune response (GO:0002312)3.09275270
101negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04945384
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02837692
103positive regulation of cardiac muscle cell differentiation (GO:2000727)3.01776630
104mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.98676764
105maintenance of protein location in nucleus (GO:0051457)2.98138092
106somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.98096666
107isotype switching (GO:0045190)2.98096666
108somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.98096666
109regulation of cholesterol storage (GO:0010885)2.97549791
110indolalkylamine metabolic process (GO:0006586)2.96350594
111regulation of action potential (GO:0098900)2.96279916
112peristalsis (GO:0030432)2.94902294
113mesenchymal cell differentiation (GO:0048762)2.94541352
114regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.93712012
115postsynaptic membrane organization (GO:0001941)2.92808814
116histamine transport (GO:0051608)2.92646315
117negative regulation of DNA biosynthetic process (GO:2000279)2.88712535
118tryptophan metabolic process (GO:0006568)2.87781038
119regulation of DNA endoreduplication (GO:0032875)2.86745217
120kynurenine metabolic process (GO:0070189)2.84758559
121fat-soluble vitamin catabolic process (GO:0042363)2.84097371
122vitamin catabolic process (GO:0009111)2.84097371
123positive regulation of cellular amide metabolic process (GO:0034250)2.83737947
124T cell differentiation involved in immune response (GO:0002292)2.83670634
125alpha-beta T cell differentiation involved in immune response (GO:0002293)2.83670634
126alpha-beta T cell activation involved in immune response (GO:0002287)2.83670634
127regulation of interleukin-8 biosynthetic process (GO:0045414)2.83542179
128positive regulation of triglyceride biosynthetic process (GO:0010867)2.83320718
129embryonic camera-type eye development (GO:0031076)2.83184017
130otic vesicle formation (GO:0030916)2.82288741
131chromosome organization involved in meiosis (GO:0070192)2.82174652
132TOR signaling (GO:0031929)2.81348144
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77673907
134mitochondrial calcium ion homeostasis (GO:0051560)2.77610682
135protein polyglutamylation (GO:0018095)2.77392768
136indole-containing compound catabolic process (GO:0042436)2.76633191
137indolalkylamine catabolic process (GO:0046218)2.76633191
138tryptophan catabolic process (GO:0006569)2.76633191
139centriole assembly (GO:0098534)2.75873262
140sulfate transport (GO:0008272)2.75109787
141cytochrome complex assembly (GO:0017004)2.75087985
142positive regulation of heat generation (GO:0031652)2.74102222
143cranial nerve structural organization (GO:0021604)2.71917953
144kinetochore organization (GO:0051383)2.71526932
145B cell mediated immunity (GO:0019724)2.71053673
146response to UV-C (GO:0010225)2.69669835
147response to protozoan (GO:0001562)2.69562150
148proteasome assembly (GO:0043248)2.67131189
149regulation of activation of Janus kinase activity (GO:0010533)2.65400698
150G-protein coupled receptor internalization (GO:0002031)2.65024757
151detection of other organism (GO:0098543)2.64673920
152cell differentiation involved in kidney development (GO:0061005)2.63404812
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61496434
154regulation of fever generation (GO:0031620)2.60707202
155regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60587960
156replicative senescence (GO:0090399)2.57556263
157DNA double-strand break processing (GO:0000729)2.54434669
158regulation of sarcomere organization (GO:0060297)2.54286761
159regulation of timing of cell differentiation (GO:0048505)2.54136799
160reflex (GO:0060004)2.53288754
161superoxide metabolic process (GO:0006801)2.52669626
162CD4-positive, alpha-beta T cell activation (GO:0035710)2.50128442
163CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47829188
164negative regulation of DNA-dependent DNA replication (GO:2000104)2.47654030
165startle response (GO:0001964)2.46821145
166positive regulation of protein homodimerization activity (GO:0090073)2.44162274
167meiotic chromosome segregation (GO:0045132)2.44057423
168protein heterotetramerization (GO:0051290)2.43757359
169lipoxygenase pathway (GO:0019372)2.42285638
170DNA integration (GO:0015074)2.40590652
171B cell differentiation (GO:0030183)2.40204806
172androgen biosynthetic process (GO:0006702)2.39963470
173rRNA catabolic process (GO:0016075)2.38060952
174presynaptic membrane assembly (GO:0097105)2.37977335
175negative regulation of keratinocyte proliferation (GO:0010839)2.37640241
176respiratory chain complex IV assembly (GO:0008535)2.37006291
177I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.36804280
178dentate gyrus development (GO:0021542)2.36469245
179oligosaccharide biosynthetic process (GO:0009312)2.36123541
180positive regulation of DNA-dependent DNA replication (GO:2000105)2.33597736
181detection of bacterium (GO:0016045)2.33596050
182response to X-ray (GO:0010165)2.33580759
183transcription from mitochondrial promoter (GO:0006390)2.33538463
184cerebral cortex cell migration (GO:0021795)2.32505301
185modulation by virus of host process (GO:0019054)2.32207299
186detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31032027
187regulation of helicase activity (GO:0051095)2.30201517
188cell differentiation involved in metanephros development (GO:0072202)2.29737315
189regulation of cilium movement (GO:0003352)2.28602916
190centriole replication (GO:0007099)2.28240978
191cellular response to exogenous dsRNA (GO:0071360)2.26609174
192inner ear receptor stereocilium organization (GO:0060122)2.23787413
193negative regulation of viral genome replication (GO:0045071)2.23685056
194female gonad development (GO:0008585)2.23475590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.21114480
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.96977381
3GBX2_23144817_ChIP-Seq_PC3_Human3.91309716
4EZH2_22144423_ChIP-Seq_EOC_Human3.90438548
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.66064430
6ZFP57_27257070_Chip-Seq_ESCs_Mouse3.01626654
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79972253
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.77946946
9ZNF274_21170338_ChIP-Seq_K562_Hela2.76443572
10IGF1R_20145208_ChIP-Seq_DFB_Human2.61050637
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60540327
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56387294
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53225583
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.47562063
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.31884773
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.28216110
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.25085611
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.22871589
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.22741953
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15344127
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12143105
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11879184
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.11614250
24IRF1_19129219_ChIP-ChIP_H3396_Human2.07364180
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.05947500
26TDRD3_21172665_ChIP-Seq_MCF-7_Human2.01560767
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95295653
28MYC_18940864_ChIP-ChIP_HL60_Human1.95058750
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91669821
30TAF15_26573619_Chip-Seq_HEK293_Human1.89160741
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88920982
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.86417324
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.85759878
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82093405
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.81604362
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81540811
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.79900664
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.79266661
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77107026
40P300_19829295_ChIP-Seq_ESCs_Human1.76257880
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76080855
42P53_22387025_ChIP-Seq_ESCs_Mouse1.75486340
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74795553
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74616919
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73438771
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.72522965
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.70255457
48NMYC_18555785_Chip-Seq_ESCs_Mouse1.67492733
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.66866823
50RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65893418
51OCT4_18555785_Chip-Seq_ESCs_Mouse1.65727316
52AHR_22903824_ChIP-Seq_MCF-7_Human1.60961062
53RNF2_27304074_Chip-Seq_NSC_Mouse1.58848919
54P300_18555785_Chip-Seq_ESCs_Mouse1.56798989
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56553315
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56107410
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.54464635
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54254714
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.53047863
60SOX2_18555785_Chip-Seq_ESCs_Mouse1.52284169
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51658082
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.50380485
63ER_23166858_ChIP-Seq_MCF-7_Human1.47170625
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47011365
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46872866
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46872866
67* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46254664
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45490130
69PU1_27457419_Chip-Seq_LIVER_Mouse1.45418079
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.45020200
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.44994514
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.44099895
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43806001
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.42829541
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41141150
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.41075556
77BCAT_22108803_ChIP-Seq_LS180_Human1.39711407
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.38628805
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37588884
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.37070147
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.34638891
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32963550
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31221548
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28806191
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.28408769
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.28072900
87EWS_26573619_Chip-Seq_HEK293_Human1.28005942
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27987601
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27613431
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27577333
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.27202977
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25622494
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.25483659
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25248304
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24135446
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.24073053
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23408756
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22919385
99STAT3_23295773_ChIP-Seq_U87_Human1.22191471
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.21143813
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20580128
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19599208
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19274847
104FUS_26573619_Chip-Seq_HEK293_Human1.18624210
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17371199
106VDR_22108803_ChIP-Seq_LS180_Human1.16489035
107E2F7_22180533_ChIP-Seq_HELA_Human1.16118259
108* AR_25329375_ChIP-Seq_VCAP_Human1.16055002
109RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15734028
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15734028
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15562648
112JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15378671
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.14732982
114RNF2_27304074_Chip-Seq_ESCs_Mouse1.14449737
115TCF4_23295773_ChIP-Seq_U87_Human1.13989863
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.13717241
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13615437
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13118835
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12734346
120TP53_18474530_ChIP-ChIP_U2OS_Human1.12674944
121AR_21572438_ChIP-Seq_LNCaP_Human1.12630094
122E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11204354
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10931526
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08271084
125KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07082285
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06766131
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.06328104
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05330016
129RUNX2_22187159_ChIP-Seq_PCA_Human1.05285494
130SRF_21415370_ChIP-Seq_HL-1_Mouse1.05168043
131* NCOR_22424771_ChIP-Seq_293T_Human1.04692686
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04580007
133REST_21632747_ChIP-Seq_MESCs_Mouse1.04479777
134FOXA1_25329375_ChIP-Seq_VCAP_Human1.04313087
135FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04313087
136NANOG_16153702_ChIP-ChIP_HESCs_Human1.02276665
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.99204622
138KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98518712
139CBP_20019798_ChIP-Seq_JUKART_Human0.98423954
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98423954
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.95709962
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94115486
143TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91749636
144* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88924293
145JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87386792
146TP53_20018659_ChIP-ChIP_R1E_Mouse0.85917957
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85611348
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85443759
149ETS1_20019798_ChIP-Seq_JURKAT_Human0.84783637
150TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84608778
151TP53_22573176_ChIP-Seq_HFKS_Human0.84082501
152TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83554941
153SOX2_19829295_ChIP-Seq_ESCs_Human0.81856685
154NANOG_19829295_ChIP-Seq_ESCs_Human0.81856685
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79260129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.72103531
2MP0006292_abnormal_olfactory_placode4.38396695
3MP0001188_hyperpigmentation4.34942049
4MP0003136_yellow_coat_color3.82543288
5MP0001485_abnormal_pinna_reflex3.81486053
6MP0000516_abnormal_urinary_system3.45724250
7MP0005367_renal/urinary_system_phenotyp3.45724250
8MP0000013_abnormal_adipose_tissue3.01725333
9MP0008260_abnormal_autophagy2.92020972
10MP0002160_abnormal_reproductive_system2.89005790
11MP0003787_abnormal_imprinting2.66191405
12MP0002876_abnormal_thyroid_physiology2.60722675
13MP0000566_synostosis2.55381101
14MP0005645_abnormal_hypothalamus_physiol2.42553246
15MP0005171_absent_coat_pigmentation2.42466105
16MP0005409_darkened_coat_color2.30679614
17MP0002102_abnormal_ear_morphology2.30296928
18MP0008058_abnormal_DNA_repair2.24166422
19MP0002277_abnormal_respiratory_mucosa2.23307285
20MP0003718_maternal_effect2.21450891
21MP0001849_ear_inflammation2.18598718
22MP0009053_abnormal_anal_canal2.16579263
23MP0008872_abnormal_physiological_respon2.14085955
24MP0002396_abnormal_hematopoietic_system2.08442405
25MP0001835_abnormal_antigen_presentation2.02194960
26MP0005389_reproductive_system_phenotype1.92489095
27MP0008995_early_reproductive_senescence1.90407345
28MP0001986_abnormal_taste_sensitivity1.89384584
29MP0003119_abnormal_digestive_system1.85932404
30MP0004185_abnormal_adipocyte_glucose1.83734016
31MP0003724_increased_susceptibility_to1.82263444
32MP0005646_abnormal_pituitary_gland1.78616057
33MP0009384_cardiac_valve_regurgitation1.75307412
34MP0001661_extended_life_span1.75004567
35MP0002163_abnormal_gland_morphology1.72096690
36MP0003880_abnormal_central_pattern1.71585060
37MP0002282_abnormal_trachea_morphology1.67710501
38MP0004130_abnormal_muscle_cell1.61035319
39MP0000015_abnormal_ear_pigmentation1.58991018
40MP0001486_abnormal_startle_reflex1.57515246
41MP0008057_abnormal_DNA_replication1.56611772
42MP0009765_abnormal_xenobiotic_induced1.56066317
43MP0002148_abnormal_hypersensitivity_rea1.55503351
44MP0003941_abnormal_skin_development1.53418451
45MP0003011_delayed_dark_adaptation1.48646016
46MP0003936_abnormal_reproductive_system1.47907162
47MP0009764_decreased_sensitivity_to1.47778696
48MP0000681_abnormal_thyroid_gland1.46798110
49MP0004019_abnormal_vitamin_homeostasis1.46486867
50MP0005174_abnormal_tail_pigmentation1.41106322
51MP0002751_abnormal_autonomic_nervous1.40929145
52MP0000003_abnormal_adipose_tissue1.40484795
53MP0003890_abnormal_embryonic-extraembry1.39928513
54MP0004147_increased_porphyrin_level1.38498183
55MP0004885_abnormal_endolymph1.35056234
56MP0002419_abnormal_innate_immunity1.31615223
57MP0001440_abnormal_grooming_behavior1.29962069
58MP0004381_abnormal_hair_follicle1.27908215
59MP0009250_abnormal_appendicular_skeleto1.27149255
60MP0005451_abnormal_body_composition1.25601974
61MP0009697_abnormal_copulation1.24830466
62MP0000372_irregular_coat_pigmentation1.24717283
63MP0003111_abnormal_nucleus_morphology1.24272530
64MP0003693_abnormal_embryo_hatching1.24209054
65MP0009046_muscle_twitch1.24179275
66MP0002735_abnormal_chemical_nociception1.23232948
67MP0003283_abnormal_digestive_organ1.22138880
68MP0005671_abnormal_response_to1.21030475
69MP0003786_premature_aging1.20317168
70MP0001968_abnormal_touch/_nociception1.20159833
71MP0006082_CNS_inflammation1.17836954
72MP0000613_abnormal_salivary_gland1.17129912
73MP0002132_abnormal_respiratory_system1.15866424
74MP0008004_abnormal_stomach_pH1.14833658
75MP0009785_altered_susceptibility_to1.14399734
76MP0001984_abnormal_olfaction1.11575084
77MP0005647_abnormal_sex_gland1.11127476
78MP0004133_heterotaxia1.10854870
79MP0005257_abnormal_intraocular_pressure1.10457658
80MP0002138_abnormal_hepatobiliary_system1.10127822
81MP0010386_abnormal_urinary_bladder1.09805740
82MP0000026_abnormal_inner_ear1.07882872
83MP0000383_abnormal_hair_follicle1.07339318
84MP0008877_abnormal_DNA_methylation1.06933470
85MP0002095_abnormal_skin_pigmentation1.05452335
86MP0005379_endocrine/exocrine_gland_phen1.02587581
87MP0005551_abnormal_eye_electrophysiolog1.02277100
88MP0002272_abnormal_nervous_system1.01405868
89MP0000049_abnormal_middle_ear1.00718279
90MP0005084_abnormal_gallbladder_morpholo1.00700816
91MP0001501_abnormal_sleep_pattern0.98769252
92MP0001963_abnormal_hearing_physiology0.98652135
93MP0004142_abnormal_muscle_tone0.97191809
94MP0002249_abnormal_larynx_morphology0.95257799
95MP0005670_abnormal_white_adipose0.93633999
96MP0002928_abnormal_bile_duct0.93089229
97MP0005195_abnormal_posterior_eye0.92652747
98MP0005377_hearing/vestibular/ear_phenot0.91469879
99MP0003878_abnormal_ear_physiology0.91469879
100MP0002254_reproductive_system_inflammat0.91172635
101MP0003195_calcinosis0.90715198
102MP0002998_abnormal_bone_remodeling0.90604013
103MP0000427_abnormal_hair_cycle0.90094816
104MP0002452_abnormal_antigen_presenting0.88844358
105MP0006276_abnormal_autonomic_nervous0.88047395
106MP0005075_abnormal_melanosome_morpholog0.87768333
107MP0008789_abnormal_olfactory_epithelium0.85872375
108MP0000537_abnormal_urethra_morphology0.85774492
109MP0002723_abnormal_immune_serum0.85760928
110MP0004510_myositis0.85486793
111MP0002837_dystrophic_cardiac_calcinosis0.85419784
112MP0003938_abnormal_ear_development0.84718904
113MP0010094_abnormal_chromosome_stability0.84690154
114MP0001790_abnormal_immune_system0.83626605
115MP0005387_immune_system_phenotype0.83626605
116MP0002139_abnormal_hepatobiliary_system0.83491348
117MP0004134_abnormal_chest_morphology0.83233643
118MP0005025_abnormal_response_to0.82956912
119MP0004484_altered_response_of0.81950822
120MP0004145_abnormal_muscle_electrophysio0.80484894
121MP0005310_abnormal_salivary_gland0.80212405
122MP0005000_abnormal_immune_tolerance0.80071076
123MP0001119_abnormal_female_reproductive0.79466430
124MP0002067_abnormal_sensory_capabilities0.78919045
125MP0000647_abnormal_sebaceous_gland0.78029421
126MP0003879_abnormal_hair_cell0.77565354
127MP0001145_abnormal_male_reproductive0.77164650
128MP0001177_atelectasis0.76572878
129MP0000490_abnormal_crypts_of0.75716290
130MP0003646_muscle_fatigue0.75535392
131MP0000631_abnormal_neuroendocrine_gland0.75385415
132MP0001800_abnormal_humoral_immune0.75310163
133MP0005503_abnormal_tendon_morphology0.74977453
134MP0004782_abnormal_surfactant_physiolog0.74578913
135MP0003567_abnormal_fetal_cardiomyocyte0.73693231
136MP0003937_abnormal_limbs/digits/tail_de0.73530722
137MP0003121_genomic_imprinting0.72961387
138MP0005253_abnormal_eye_physiology0.72876024
139MP0003942_abnormal_urinary_system0.72180058
140MP0009745_abnormal_behavioral_response0.70486437
141MP0001764_abnormal_homeostasis0.70194865
142MP0002127_abnormal_cardiovascular_syste0.69674930
143MP0002210_abnormal_sex_determination0.68881372
144MP0003172_abnormal_lysosome_physiology0.68441067
145MP0002736_abnormal_nociception_after0.68388105
146MP0001819_abnormal_immune_cell0.68187577
147MP0003635_abnormal_synaptic_transmissio0.67979891
148MP0003315_abnormal_perineum_morphology0.67887800
149MP0000534_abnormal_ureter_morphology0.66736876
150MP0003763_abnormal_thymus_physiology0.66625599
151MP0002064_seizures0.66416961
152MP0000230_abnormal_systemic_arterial0.64789030
153MP0000653_abnormal_sex_gland0.64339660
154MP0008770_decreased_survivor_rate0.63003638
155MP0002116_abnormal_craniofacial_bone0.62085454
156MP0000470_abnormal_stomach_morphology0.61385807
157MP0009115_abnormal_fat_cell0.61267577
158MP0000678_abnormal_parathyroid_gland0.61233294
159MP0006072_abnormal_retinal_apoptosis0.58348577
160MP0001919_abnormal_reproductive_system0.56322153
161MP0008873_increased_physiological_sensi0.56111324
162MP0002135_abnormal_kidney_morphology0.54725457
163MP0003638_abnormal_response/metabolism_0.54529980

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)8.60632521
2Chromsome breakage (HP:0040012)7.71044712
3Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)6.77438501
4Short 1st metacarpal (HP:0010034)6.77438501
5Stenosis of the external auditory canal (HP:0000402)6.01903986
6Abnormality of the 1st metacarpal (HP:0010009)5.95106975
7Carpal bone hypoplasia (HP:0001498)5.12260982
8Short phalanx of the thumb (HP:0009660)4.77608225
9Asymmetry of the thorax (HP:0001555)4.47155796
10Absent thumb (HP:0009777)4.42155432
11Aplastic anemia (HP:0001915)4.37978570
12Aplasia/Hypoplasia of the uvula (HP:0010293)4.16833825
13Fused cervical vertebrae (HP:0002949)4.14647833
14Pendular nystagmus (HP:0012043)4.04788353
15Abnormality of the preputium (HP:0100587)4.02514501
16Meckel diverticulum (HP:0002245)3.93766830
17Short hallux (HP:0010109)3.91743917
18Abnormality of chromosome stability (HP:0003220)3.78431450
19Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.78363407
20Abnormality of the ileum (HP:0001549)3.75811992
21Fibular aplasia (HP:0002990)3.68153572
22Aplasia/Hypoplasia of the hallux (HP:0008362)3.66991757
23Prostate neoplasm (HP:0100787)3.66317370
24Rectal fistula (HP:0100590)3.64510335
25Rectovaginal fistula (HP:0000143)3.64510335
26Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.58609182
27Clubbing of toes (HP:0100760)3.57304644
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.45916911
29Nephroblastoma (Wilms tumor) (HP:0002667)3.41722132
30Aplasia/Hypoplasia involving the musculature (HP:0001460)3.32279632
31Febrile seizures (HP:0002373)3.28264073
32Fibular hypoplasia (HP:0003038)3.20408706
33Embryonal renal neoplasm (HP:0011794)3.19028558
34Intestinal fistula (HP:0100819)3.17485655
35Horseshoe kidney (HP:0000085)3.10317898
36Septo-optic dysplasia (HP:0100842)3.05021812
37Vaginal fistula (HP:0004320)2.98180630
38Anomalous pulmonary venous return (HP:0010772)2.94486210
39Synostosis of carpal bones (HP:0005048)2.83348866
40Abnormality of the parathyroid morphology (HP:0011766)2.82401706
41Abnormality of the nasal septum (HP:0000419)2.80382671
42Absent radius (HP:0003974)2.80074178
43Small intestinal stenosis (HP:0012848)2.79585815
44Duodenal stenosis (HP:0100867)2.79585815
45Abolished electroretinogram (ERG) (HP:0000550)2.76654187
46Reticulocytopenia (HP:0001896)2.71222100
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70607747
48Natal tooth (HP:0000695)2.69325907
49Absent forearm bone (HP:0003953)2.67306230
50Aplasia involving forearm bones (HP:0009822)2.67306230
51Genetic anticipation (HP:0003743)2.64236158
52Short humerus (HP:0005792)2.61460681
53Oligomenorrhea (HP:0000876)2.60545474
54Abnormality of the proximal phalanges of the hand (HP:0009834)2.57977853
55Renal cortical cysts (HP:0000803)2.57599421
56Abnormality of the carotid arteries (HP:0005344)2.55052724
57Acute necrotizing encephalopathy (HP:0006965)2.54894456
58Abnormality of the pulmonary veins (HP:0011718)2.53903341
59Aplasia/hypoplasia of the humerus (HP:0006507)2.52926760
60Decreased subcutaneous fat (HP:0001002)2.52498480
61Duplicated collecting system (HP:0000081)2.51894620
62Chorioretinal atrophy (HP:0000533)2.51254055
63Focal motor seizures (HP:0011153)2.48776400
64Thoracic kyphosis (HP:0002942)2.46748541
65Ectopic kidney (HP:0000086)2.45070979
66Anal stenosis (HP:0002025)2.44981108
67Medulloblastoma (HP:0002885)2.42862406
68Oligohydramnios (HP:0001562)2.42792877
69Type 2 muscle fiber atrophy (HP:0003554)2.41408719
703-Methylglutaconic aciduria (HP:0003535)2.40947168
71Vertebral fusion (HP:0002948)2.40945832
72Increased corneal curvature (HP:0100692)2.38778165
73Keratoconus (HP:0000563)2.38778165
74Type I transferrin isoform profile (HP:0003642)2.37871520
75Pancreatic cysts (HP:0001737)2.36371455
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.35068064
77Absent/shortened dynein arms (HP:0200106)2.35068064
78Supernumerary spleens (HP:0009799)2.34561306
79Tachypnea (HP:0002789)2.33009493
80Osteomalacia (HP:0002749)2.30849754
81Abnormality of the renal collecting system (HP:0004742)2.29634439
82Neoplasm of the oral cavity (HP:0100649)2.26555502
83Abnormality of pyrimidine metabolism (HP:0004353)2.26294270
84Abnormal mitochondria in muscle tissue (HP:0008316)2.26148800
85Absent septum pellucidum (HP:0001331)2.25362934
86Reduced antithrombin III activity (HP:0001976)2.23277633
87Joint hemorrhage (HP:0005261)2.22961104
88Prolonged neonatal jaundice (HP:0006579)2.22507142
89Bone marrow hypocellularity (HP:0005528)2.21568519
90Aplasia/Hypoplasia of the tibia (HP:0005772)2.21138250
91Abnormality of the duodenum (HP:0002246)2.19582257
92Short tibia (HP:0005736)2.19282561
93Progressive macrocephaly (HP:0004481)2.18343785
94Abnormality of the prostate (HP:0008775)2.17676046
95Craniofacial hyperostosis (HP:0004493)2.14646592
96Optic nerve coloboma (HP:0000588)2.12867181
97Chronic hepatic failure (HP:0100626)2.12705004
98Optic nerve hypoplasia (HP:0000609)2.11986996
99Congenital stationary night blindness (HP:0007642)2.10375469
100Vitreoretinal degeneration (HP:0000655)2.09716596
101Panhypogammaglobulinemia (HP:0003139)2.09443253
102Bifid uvula (HP:0000193)2.07303404
103Pancreatic fibrosis (HP:0100732)2.06618729
104Short thumb (HP:0009778)2.04518391
105Renal agenesis (HP:0000104)2.04216108
106True hermaphroditism (HP:0010459)2.04026460
107Carpal synostosis (HP:0009702)2.02897682
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.02123011
109Tubulointerstitial nephritis (HP:0001970)2.01764611
110Aplasia/Hypoplasia of the fibula (HP:0006492)2.01543500
111Insulin-resistant diabetes mellitus (HP:0000831)2.00998626
112Thyroiditis (HP:0100646)2.00726100
113White forelock (HP:0002211)2.00658547
114Progressive cerebellar ataxia (HP:0002073)2.00276327
115Retrobulbar optic neuritis (HP:0100654)1.99939939
116Optic neuritis (HP:0100653)1.99939939
117Acute encephalopathy (HP:0006846)1.99830258
118Morphological abnormality of the middle ear (HP:0008609)1.98252855
119Hypoplasia of the ulna (HP:0003022)1.98106913
120Abnormality of subcutaneous fat tissue (HP:0001001)1.98094723
121Myelodysplasia (HP:0002863)1.96550002
122Abnormality of the septum pellucidum (HP:0007375)1.96490562
123Toxemia of pregnancy (HP:0100603)1.96448301
124Nasal speech (HP:0001611)1.95055737
125Maternal diabetes (HP:0009800)1.94618342
126Embryonal neoplasm (HP:0002898)1.93631577
127Partial agenesis of the corpus callosum (HP:0001338)1.93404674
128Rough bone trabeculation (HP:0100670)1.93300936
129Pancytopenia (HP:0001876)1.93142155
130Porencephaly (HP:0002132)1.91292538
131Severe muscular hypotonia (HP:0006829)1.90978140
132Thickened calvaria (HP:0002684)1.90880917
133Hypoplasia of the thymus (HP:0000778)1.90043647
134Hypoplasia of the radius (HP:0002984)1.89293825
135Patchy hypopigmentation of hair (HP:0011365)1.88443787
136Short middle phalanx of the 5th finger (HP:0004220)1.87295167
137Mitochondrial inheritance (HP:0001427)1.87102121
138Ureteral duplication (HP:0000073)1.86993741
139Hypoalphalipoproteinemia (HP:0003233)1.86334217
140Bony spicule pigmentary retinopathy (HP:0007737)1.86035536
141Methylmalonic acidemia (HP:0002912)1.85752085
142Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84374737
143Alveolar cell carcinoma (HP:0006519)1.83639964
144Cranial hyperostosis (HP:0004437)1.82154741
145Chronic mucocutaneous candidiasis (HP:0002728)1.82136557
146Recurrent cutaneous fungal infections (HP:0011370)1.82136557
147Nonprogressive disorder (HP:0003680)1.81695768
148Severe combined immunodeficiency (HP:0004430)1.81436619
149Recurrent pneumonia (HP:0006532)1.81432868
150Hypoplasia of the uterus (HP:0000013)1.81047702
151Pulmonary artery stenosis (HP:0004415)1.81014154
152Stomach cancer (HP:0012126)1.80848442
153Acanthocytosis (HP:0001927)1.80283298
154Abnormality of DNA repair (HP:0003254)1.80234243
155B lymphocytopenia (HP:0010976)1.78610611
156Muscle fiber atrophy (HP:0100295)1.78455708
157Abnormal trabecular bone morphology (HP:0100671)1.78320730
158Tented upper lip vermilion (HP:0010804)1.76606074
159Esotropia (HP:0000565)1.75637744
160Abnormality of the thoracic spine (HP:0100711)1.75472671
161Abnormal ciliary motility (HP:0012262)1.75042490
162Double outlet right ventricle (HP:0001719)1.74556668
163Congenital malformation of the right heart (HP:0011723)1.74556668
164Encephalitis (HP:0002383)1.74076331
165Posterior subcapsular cataract (HP:0007787)1.73218805
166Triphalangeal thumb (HP:0001199)1.72966293
167Petechiae (HP:0000967)1.72669775
168Abnormal lung lobation (HP:0002101)1.70668047
169Abnormal respiratory motile cilium morphology (HP:0005938)1.69452555
170Abnormal respiratory epithelium morphology (HP:0012253)1.69452555
171Conical tooth (HP:0000698)1.69450972
172Median cleft lip (HP:0000161)1.67931641
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.66834383
174Hypoplasia of the fovea (HP:0007750)1.66834383
175Congenital sensorineural hearing impairment (HP:0008527)1.66355806
176Delayed closure of the anterior fontanelle (HP:0001476)1.66264338
177Oligodactyly (hands) (HP:0001180)1.65628358
178Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65531157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.64349864
2FRK3.48644254
3IRAK33.09092663
4MKNK22.99033074
5CDK92.95951637
6TLK12.66086543
7MUSK2.64661925
8CDC72.55674507
9AKT32.51182625
10ZAK2.43074083
11TXK2.33874114
12INSRR2.24464195
13STK162.22672384
14TAOK32.17718917
15IRAK42.16103863
16MAP3K142.09719777
17EIF2AK22.07896943
18TAF12.05660530
19MAP2K72.02499043
20TNIK1.99328566
21MKNK11.96027232
22ADRBK21.88704304
23SIK31.66599876
24PIK3CG1.62981845
25PRPF4B1.62163101
26VRK11.57738446
27MAP2K11.55596786
28BLK1.47242046
29PRKCI1.46811733
30YES11.45909434
31GRK71.44630495
32STK38L1.41921474
33VRK21.41311565
34MAP4K21.41074647
35NUAK11.40322334
36ACVR1B1.39995022
37BMPR21.35804321
38TAOK21.35602248
39TNK21.34560746
40STK241.33919163
41TEC1.25268756
42STK391.23602980
43IRAK11.23000170
44RIPK41.20422672
45SIK21.18213914
46WNK31.18186716
47NTRK31.17076315
48CDK31.14527084
49AURKA1.14171078
50MAP3K41.13598779
51WNK41.12993228
52CCNB11.09899391
53IRAK21.08048127
54NEK61.05299534
55CSNK1G11.05154877
56TGFBR21.03878686
57PINK11.03807161
58CSNK1G31.03534086
59NME11.03235959
60GRK11.01510736
61MAPK131.00584752
62SRPK10.99944107
63CSNK1A1L0.99766581
64CSNK1G20.97927595
65PRKCG0.96583443
66CDK80.93584712
67PHKG20.91861411
68PHKG10.91861411
69CSNK1A10.86853223
70PAK60.82141214
71PKN10.81713080
72STK40.80936472
73DYRK20.80910854
74BRSK20.80186303
75PLK40.80164285
76DYRK30.80006098
77MAP3K60.79762770
78IKBKB0.79508071
79LYN0.76333411
80OBSCN0.75251782
81RPS6KA50.73845924
82PRKCQ0.73681283
83SGK20.73606904
84ADRBK10.70619114
85CAMK10.70404213
86EIF2AK30.69045084
87NLK0.68289550
88GRK50.68017367
89BTK0.66209957
90PIM20.66166237
91DAPK20.65738085
92CDK70.65537672
93MATK0.65468971
94PAK30.64445997
95BCR0.64005797
96CSNK1D0.63477464
97STK30.63118146
98KIT0.62399966
99SYK0.62385902
100ERBB30.60856307
101HCK0.59912266
102MST40.59789493
103TGFBR10.58954684
104PRKD20.57759590
105PRKCE0.57071091
106TTK0.56210211
107BRD40.55937074
108ATR0.54271664
109BUB10.53023413
110CHUK0.52830640
111WEE10.51501401
112CAMK40.51366278
113PRKAA20.51293002
114ERBB40.50158304
115BMPR1B0.50020168
116MAPK120.48915327
117EPHA40.47624659
118FES0.47296888
119MAP3K50.47273323
120PRKCH0.47118107
121PRKACA0.47038684
122CHEK20.45564169
123CSNK2A10.44281407
124PLK20.43253595
125MAPK70.41515085
126PRKAA10.40514335
127RPS6KB10.40414096
128ATM0.40341660
129CAMK2A0.39675011
130TRPM70.39645716
131TRIM280.39643045
132MAPKAPK30.39483152
133CSF1R0.39210644
134STK380.38773384
135PIM10.38701612
136TIE10.37793800
137PLK30.37677321
138PIK3CA0.37295631
139SGK4940.36519595
140SGK2230.36519595
141PTK2B0.35982351
142CLK10.35933188
143NEK90.35792591
144OXSR10.35670969
145CHEK10.35623387
146PBK0.35530809
147MAPK110.35331752
148PDK20.35268158
149MAPK80.35113925
150STK110.35100280
151MAP3K130.34000321
152PRKG10.33947212
153FLT30.33905165
154IKBKE0.33878912
155AKT20.33123310
156AURKB0.32984009
157NME20.32521117
158PLK10.32473983
159LCK0.31683734

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.76594973
2Renin-angiotensin system_Homo sapiens_hsa046142.91770835
3Selenocompound metabolism_Homo sapiens_hsa004502.64332043
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59866683
5Nicotine addiction_Homo sapiens_hsa050332.57616316
6Sulfur metabolism_Homo sapiens_hsa009202.49896484
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27905745
8Vitamin digestion and absorption_Homo sapiens_hsa049772.25010583
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.17133959
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.13122627
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08773703
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05420639
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.02379609
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.01696556
15Homologous recombination_Homo sapiens_hsa034401.95774340
16Allograft rejection_Homo sapiens_hsa053301.92178243
17Graft-versus-host disease_Homo sapiens_hsa053321.78515020
18Basal cell carcinoma_Homo sapiens_hsa052171.71933198
19Taste transduction_Homo sapiens_hsa047421.71890254
20Phototransduction_Homo sapiens_hsa047441.70983212
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70276306
22Olfactory transduction_Homo sapiens_hsa047401.69412403
23Autoimmune thyroid disease_Homo sapiens_hsa053201.66894554
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64815470
25Oxidative phosphorylation_Homo sapiens_hsa001901.62409586
26Rheumatoid arthritis_Homo sapiens_hsa053231.59660363
27Dorso-ventral axis formation_Homo sapiens_hsa043201.57991165
28Regulation of autophagy_Homo sapiens_hsa041401.56430035
29Chemical carcinogenesis_Homo sapiens_hsa052041.55367163
30Arachidonic acid metabolism_Homo sapiens_hsa005901.52824001
31Nitrogen metabolism_Homo sapiens_hsa009101.43474335
32Non-homologous end-joining_Homo sapiens_hsa034501.42685816
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42057827
34Type I diabetes mellitus_Homo sapiens_hsa049401.41294929
35Morphine addiction_Homo sapiens_hsa050321.36251557
36RNA polymerase_Homo sapiens_hsa030201.32085221
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31888796
38Asthma_Homo sapiens_hsa053101.31056488
39Sphingolipid metabolism_Homo sapiens_hsa006001.30304616
40Malaria_Homo sapiens_hsa051441.30211803
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29876527
42Hematopoietic cell lineage_Homo sapiens_hsa046401.26031148
43TNF signaling pathway_Homo sapiens_hsa046681.22636551
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21441566
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20336177
46Alcoholism_Homo sapiens_hsa050341.20273826
47Measles_Homo sapiens_hsa051621.18044191
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17890894
49Alzheimers disease_Homo sapiens_hsa050101.16855223
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16833484
51Tryptophan metabolism_Homo sapiens_hsa003801.16003041
52Basal transcription factors_Homo sapiens_hsa030221.15143654
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15025798
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13620052
55Huntingtons disease_Homo sapiens_hsa050161.12933854
56Parkinsons disease_Homo sapiens_hsa050121.12799108
57Steroid biosynthesis_Homo sapiens_hsa001001.08499508
58Staphylococcus aureus infection_Homo sapiens_hsa051501.07187148
59Folate biosynthesis_Homo sapiens_hsa007901.01620812
60Mismatch repair_Homo sapiens_hsa034301.01614914
61Other glycan degradation_Homo sapiens_hsa005111.00667691
62Purine metabolism_Homo sapiens_hsa002300.99808621
63Vitamin B6 metabolism_Homo sapiens_hsa007500.95015809
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94276062
65Leishmaniasis_Homo sapiens_hsa051400.94019860
66Caffeine metabolism_Homo sapiens_hsa002320.93319928
67African trypanosomiasis_Homo sapiens_hsa051430.93228192
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91664783
69Calcium signaling pathway_Homo sapiens_hsa040200.91442092
70Herpes simplex infection_Homo sapiens_hsa051680.87111031
71Glycerolipid metabolism_Homo sapiens_hsa005610.86082460
72Primary immunodeficiency_Homo sapiens_hsa053400.85123627
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84155990
74Ether lipid metabolism_Homo sapiens_hsa005650.83658009
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82051791
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82026249
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.81600153
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77196706
79Insulin secretion_Homo sapiens_hsa049110.76933792
80beta-Alanine metabolism_Homo sapiens_hsa004100.76695324
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76077661
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75706992
83Linoleic acid metabolism_Homo sapiens_hsa005910.75429647
84Tuberculosis_Homo sapiens_hsa051520.75168069
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74509679
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.73867274
87Pyrimidine metabolism_Homo sapiens_hsa002400.72205511
88Glutamatergic synapse_Homo sapiens_hsa047240.71667238
89Protein export_Homo sapiens_hsa030600.70839272
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70415752
91Base excision repair_Homo sapiens_hsa034100.70175998
92Histidine metabolism_Homo sapiens_hsa003400.69004470
93Chemokine signaling pathway_Homo sapiens_hsa040620.67336986
94Serotonergic synapse_Homo sapiens_hsa047260.66927326
95Salivary secretion_Homo sapiens_hsa049700.66829651
96Influenza A_Homo sapiens_hsa051640.66623835
97Pertussis_Homo sapiens_hsa051330.66163879
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63174948
99Retinol metabolism_Homo sapiens_hsa008300.61412712
100DNA replication_Homo sapiens_hsa030300.61359920
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59818928
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59010518
103Hedgehog signaling pathway_Homo sapiens_hsa043400.58335363
104RNA degradation_Homo sapiens_hsa030180.57670334
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56963156
106ABC transporters_Homo sapiens_hsa020100.56902325
107Ovarian steroidogenesis_Homo sapiens_hsa049130.55429406
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54275896
109Fat digestion and absorption_Homo sapiens_hsa049750.53123688
110cAMP signaling pathway_Homo sapiens_hsa040240.52017226
111Thyroid cancer_Homo sapiens_hsa052160.51698755
112Ribosome_Homo sapiens_hsa030100.50290595
113Axon guidance_Homo sapiens_hsa043600.49232591
114Hippo signaling pathway_Homo sapiens_hsa043900.48300150
115Cardiac muscle contraction_Homo sapiens_hsa042600.47701093
116Osteoclast differentiation_Homo sapiens_hsa043800.47500718
117Butanoate metabolism_Homo sapiens_hsa006500.46992799
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45413723
119Cell cycle_Homo sapiens_hsa041100.45250485
120Inositol phosphate metabolism_Homo sapiens_hsa005620.44281727
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.43991424
122Sulfur relay system_Homo sapiens_hsa041220.43820667
123GABAergic synapse_Homo sapiens_hsa047270.41983359
124Melanoma_Homo sapiens_hsa052180.41729265
125Phagosome_Homo sapiens_hsa041450.39687786
126Nucleotide excision repair_Homo sapiens_hsa034200.38407418
127Mineral absorption_Homo sapiens_hsa049780.38043815
128PPAR signaling pathway_Homo sapiens_hsa033200.37692716
129Peroxisome_Homo sapiens_hsa041460.37317704
130Collecting duct acid secretion_Homo sapiens_hsa049660.37184277
131TGF-beta signaling pathway_Homo sapiens_hsa043500.35235479
132Circadian entrainment_Homo sapiens_hsa047130.34818158
133Proteasome_Homo sapiens_hsa030500.34779992
134Metabolic pathways_Homo sapiens_hsa011000.34203711
135One carbon pool by folate_Homo sapiens_hsa006700.33166457
136Wnt signaling pathway_Homo sapiens_hsa043100.32739911
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32452486
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31454783
139RNA transport_Homo sapiens_hsa030130.31413103
140Systemic lupus erythematosus_Homo sapiens_hsa053220.31336776
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31048832
142Gastric acid secretion_Homo sapiens_hsa049710.30300844
143Ras signaling pathway_Homo sapiens_hsa040140.29284623
144Apoptosis_Homo sapiens_hsa042100.28916270
145p53 signaling pathway_Homo sapiens_hsa041150.28678895

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