GCM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lipoprotein particle (GO:0055094)9.81293298
2response to lead ion (GO:0010288)9.52000433
3aminoglycoside antibiotic metabolic process (GO:0030647)9.46426004
4cellular response to vitamin D (GO:0071305)9.19746559
5sodium ion export (GO:0071436)8.30907146
6membrane repolarization during cardiac muscle cell action potential (GO:0086013)8.28416593
7response to vitamin D (GO:0033280)8.25830829
8cellular potassium ion homeostasis (GO:0030007)7.75861229
9cellular response to vitamin (GO:0071295)7.34703240
10membrane repolarization during action potential (GO:0086011)7.28996888
11negative regulation of meiosis (GO:0045835)6.86605949
12cellular response to hepatocyte growth factor stimulus (GO:0035729)6.69188978
13response to hepatocyte growth factor (GO:0035728)6.69188978
14positive regulation of calcium ion import (GO:0090280)6.66818153
15drinking behavior (GO:0042756)6.50655770
16detection of molecule of bacterial origin (GO:0032490)6.40732306
17positive regulation of glycogen biosynthetic process (GO:0045725)6.32220098
18relaxation of cardiac muscle (GO:0055119)6.09219954
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.02426462
20negative regulation of macroautophagy (GO:0016242)5.97423094
21peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.76292474
22detection of calcium ion (GO:0005513)5.68812520
23positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.45508643
24negative regulation of smooth muscle cell differentiation (GO:0051151)5.45052953
25positive regulation of sodium ion transmembrane transporter activity (GO:2000651)5.44702124
26positive regulation of glycogen metabolic process (GO:0070875)5.42883163
27auditory receptor cell stereocilium organization (GO:0060088)5.32708083
28regulation of activation of Janus kinase activity (GO:0010533)5.27893920
29cell communication by electrical coupling (GO:0010644)5.23385223
30neural tube formation (GO:0001841)5.18595436
31sulfate transmembrane transport (GO:1902358)5.15045363
32regulation of meiosis (GO:0040020)5.11432027
33negative regulation of digestive system process (GO:0060457)5.04286884
34positive regulation of glucose import (GO:0046326)5.03558364
35negative regulation of microtubule polymerization (GO:0031115)4.89721488
36negative regulation of appetite (GO:0032099)4.86288351
37negative regulation of response to food (GO:0032096)4.86288351
38membrane repolarization (GO:0086009)4.83850719
39cellular sodium ion homeostasis (GO:0006883)4.83807132
40chemosensory behavior (GO:0007635)4.75738339
41sulfate transport (GO:0008272)4.70466065
42bone resorption (GO:0045453)4.62667036
43energy homeostasis (GO:0097009)4.56757207
44response to pheromone (GO:0019236)4.56099952
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.53398755
46short-term memory (GO:0007614)4.43210969
47post-embryonic morphogenesis (GO:0009886)4.40244293
48CD4-positive, alpha-beta T cell differentiation (GO:0043367)4.37485242
49hormone catabolic process (GO:0042447)4.34109599
50negative regulation of meiotic cell cycle (GO:0051447)4.31193572
51bone morphogenesis (GO:0060349)4.28940843
52positive regulation of glucose transport (GO:0010828)4.26775323
53potassium ion import (GO:0010107)4.25932254
54detection of external biotic stimulus (GO:0098581)4.22996419
55mannose metabolic process (GO:0006013)4.22471085
56negative regulation of cell size (GO:0045792)4.12560561
57potassium ion homeostasis (GO:0055075)4.09723862
58regulation of meiotic cell cycle (GO:0051445)4.06284918
59CD4-positive, alpha-beta T cell activation (GO:0035710)4.05339680
60piRNA metabolic process (GO:0034587)3.98494304
61positive regulation of bone mineralization (GO:0030501)3.91830864
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.86543676
63positive regulation of neurological system process (GO:0031646)3.85350159
64inner ear receptor stereocilium organization (GO:0060122)3.83749359
65regulation of calcium ion import (GO:0090279)3.82493724
66estrogen biosynthetic process (GO:0006703)3.78956513
67regulation of mononuclear cell migration (GO:0071675)3.78185629
68positive regulation of biomineral tissue development (GO:0070169)3.78131553
69positive regulation of sodium ion transmembrane transport (GO:1902307)3.74161359
70regulation of glucose import in response to insulin stimulus (GO:2001273)3.70727154
71regulation of macrophage chemotaxis (GO:0010758)3.70314270
72regulation of appetite (GO:0032098)3.67513911
73cellular response to nutrient (GO:0031670)3.66241011
74female gonad development (GO:0008585)3.65639990
75thymus development (GO:0048538)3.60093573
76cell communication involved in cardiac conduction (GO:0086065)3.57574281
77regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.55083917
78regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.54910832
79DNA damage induced protein phosphorylation (GO:0006975)3.51282487
80prostate gland growth (GO:0060736)3.47040591
81DNA methylation involved in gamete generation (GO:0043046)3.46670215
82positive regulation of ATPase activity (GO:0032781)3.45709836
83positive regulation of ATP catabolic process (GO:1903291)3.45709836
84positive regulation of uterine smooth muscle contraction (GO:0070474)3.45560600
85relaxation of muscle (GO:0090075)3.45557645
86detection of biotic stimulus (GO:0009595)3.44321702
87response to ischemia (GO:0002931)3.43992369
88regulation of feeding behavior (GO:0060259)3.43800615
89positive regulation of Rap GTPase activity (GO:0032854)3.43192096
90negative regulation of hormone biosynthetic process (GO:0032353)3.39947080
91negative regulation of hormone metabolic process (GO:0032351)3.39947080
92negative regulation of mast cell activation (GO:0033004)3.38104812
93regulation of female gonad development (GO:2000194)3.36664986
94cytoskeletal anchoring at plasma membrane (GO:0007016)3.35892792
95cAMP metabolic process (GO:0046058)3.33449383
96vitamin catabolic process (GO:0009111)3.33042003
97fat-soluble vitamin catabolic process (GO:0042363)3.33042003
98glutamate secretion (GO:0014047)3.28628071
99positive regulation of cellular amide metabolic process (GO:0034250)3.28169633
100negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.26883750
101female gamete generation (GO:0007292)3.25449744
102male meiosis (GO:0007140)3.25106075
103peptide catabolic process (GO:0043171)3.21887460
104regulation of Rap GTPase activity (GO:0032317)3.15003263
105bicarbonate transport (GO:0015701)3.14462391
106meiotic chromosome segregation (GO:0045132)3.14048354
107production of molecular mediator involved in inflammatory response (GO:0002532)3.10931737
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10454264
109regulation of mitotic spindle checkpoint (GO:1903504)3.10454264
110regulation of response to food (GO:0032095)3.08596679
111cell wall macromolecule metabolic process (GO:0044036)3.06867615
112complement activation, alternative pathway (GO:0006957)3.06259346
113negative regulation of response to nutrient levels (GO:0032108)3.06256221
114negative regulation of response to extracellular stimulus (GO:0032105)3.06256221
115negative regulation of homotypic cell-cell adhesion (GO:0034111)3.05644346
116activation of MAPKKK activity (GO:0000185)3.05322624
117synaptic vesicle docking involved in exocytosis (GO:0016081)3.01592327
118spermatid nucleus differentiation (GO:0007289)3.00956441
119meiotic cell cycle (GO:0051321)2.99581371
120serotonin receptor signaling pathway (GO:0007210)2.98233253
121positive regulation of DNA-dependent DNA replication (GO:2000105)2.98154782
122very-low-density lipoprotein particle assembly (GO:0034379)2.97518352
123inositol phosphate-mediated signaling (GO:0048016)2.97389502
124regulation of cardiac muscle contraction (GO:0055117)2.95561448
125myelin maintenance (GO:0043217)2.94523737
126positive regulation of potassium ion transport (GO:0043268)2.90514556
127mitotic metaphase plate congression (GO:0007080)2.90455830
128regulation of meiosis I (GO:0060631)2.90367451
129regulation of glucan biosynthetic process (GO:0010962)2.89209508
130regulation of glycogen biosynthetic process (GO:0005979)2.89209508
131N-glycan processing (GO:0006491)2.88551872
132regulation of glycogen metabolic process (GO:0070873)2.87338839
133negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.86627690
134embryonic epithelial tube formation (GO:0001838)2.86093141
135positive regulation of glucose metabolic process (GO:0010907)2.84805477
136lateral ventricle development (GO:0021670)2.83519663
137positive regulation of cellular response to insulin stimulus (GO:1900078)2.82787361
138negative regulation of necrotic cell death (GO:0060547)2.82705493
139regulation of apoptotic cell clearance (GO:2000425)2.82138158
140regulation of glucocorticoid secretion (GO:2000849)2.81582870
141male meiosis I (GO:0007141)2.81480263
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81254088
143polyol biosynthetic process (GO:0046173)2.80424683
144sulfur compound transport (GO:0072348)2.79809014
145proline transport (GO:0015824)2.78354961
146tachykinin receptor signaling pathway (GO:0007217)2.77918812
147positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75990612
148type B pancreatic cell development (GO:0003323)2.75285080
149phosphatidylinositol dephosphorylation (GO:0046856)2.75167382
150carnitine transmembrane transport (GO:1902603)2.74611203
151inositol metabolic process (GO:0006020)2.74497982
152regulation of exit from mitosis (GO:0007096)2.73721340
153centriole assembly (GO:0098534)2.72518860
154cellular response to gamma radiation (GO:0071480)2.71879921
155regulation of interleukin-6 biosynthetic process (GO:0045408)2.70134451
156regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68268197
157G-protein coupled receptor internalization (GO:0002031)2.65844953
158regulation of RIG-I signaling pathway (GO:0039535)2.63545940
159regulation of non-canonical Wnt signaling pathway (GO:2000050)2.62762101
160oocyte maturation (GO:0001556)2.61978039
161monoubiquitinated protein deubiquitination (GO:0035520)2.61807630
162interferon-gamma production (GO:0032609)2.58354763
163glycerophospholipid catabolic process (GO:0046475)2.55463589
164negative regulation of nuclear division (GO:0051784)2.54736852
165positive regulation of neurotransmitter secretion (GO:0001956)2.53855461
166histone H3-K36 demethylation (GO:0070544)2.52247269
167superoxide anion generation (GO:0042554)2.50421394
168regulation of retinoic acid receptor signaling pathway (GO:0048385)2.48431423
169sphingosine metabolic process (GO:0006670)2.47741309
170positive regulation of vascular permeability (GO:0043117)2.47478263
171cerebral cortex radially oriented cell migration (GO:0021799)2.47433898
172maturation of 5.8S rRNA (GO:0000460)2.44073116
173DNA catabolic process, exonucleolytic (GO:0000738)2.43971841
174replicative senescence (GO:0090399)2.43453238
175negative regulation of cell division (GO:0051782)2.41494149
176pyrimidine dimer repair (GO:0006290)2.39815892
177positive regulation of interleukin-17 production (GO:0032740)2.39026931
178positive regulation of interleukin-1 beta secretion (GO:0050718)2.37514833
179aggressive behavior (GO:0002118)2.36592144
180regulation of uterine smooth muscle contraction (GO:0070472)2.36411161
181protein K6-linked ubiquitination (GO:0085020)2.35189211
182protein-chromophore linkage (GO:0018298)2.34966414
183somatic stem cell division (GO:0048103)2.32080487
184positive regulation of protein sumoylation (GO:0033235)2.32073693
185glandular epithelial cell development (GO:0002068)2.30036191
186neuron remodeling (GO:0016322)2.28825423
187behavioral response to ethanol (GO:0048149)2.28464200
188positive regulation of meiosis (GO:0045836)2.27469394
189negative regulation of glial cell proliferation (GO:0060253)2.27161468
190histone H3-K9 modification (GO:0061647)2.25051516
191regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.24182590
192negative regulation of reproductive process (GO:2000242)2.24040153
193polyketide metabolic process (GO:0030638)14.8734024
194doxorubicin metabolic process (GO:0044598)14.8734024
195daunorubicin metabolic process (GO:0044597)14.8734024
196response to parathyroid hormone (GO:0071107)13.1205268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse9.18159797
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.91339941
3GBX2_23144817_ChIP-Seq_PC3_Human3.50458243
4EZH2_22144423_ChIP-Seq_EOC_Human3.36826767
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.35171406
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13049754
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.12556434
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64471916
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.47545447
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41036751
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.29795784
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22196155
13KAP1_22055183_ChIP-Seq_ESCs_Mouse2.21293334
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.19604465
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16696299
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14223292
17NFIB_24661679_ChIP-Seq_LUNG_Mouse2.06506007
18ZNF274_21170338_ChIP-Seq_K562_Hela1.95854230
19NFE2_27457419_Chip-Seq_LIVER_Mouse1.95481177
20* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94847599
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88334313
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.86168844
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.80427537
24GATA3_24758297_ChIP-Seq_MCF-7_Human1.77898093
25RNF2_27304074_Chip-Seq_NSC_Mouse1.77122784
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.76462796
27IGF1R_20145208_ChIP-Seq_DFB_Human1.75316726
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74639926
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.74546542
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70986596
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.69622040
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66817700
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66817700
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.65337710
35P300_19829295_ChIP-Seq_ESCs_Human1.65111766
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65093681
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64650344
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64462631
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61142784
40STAT3_18555785_Chip-Seq_ESCs_Mouse1.60533428
41FUS_26573619_Chip-Seq_HEK293_Human1.57287605
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.57274615
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57250728
44NMYC_18555785_Chip-Seq_ESCs_Mouse1.57055888
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56486806
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56178616
47P53_22387025_ChIP-Seq_ESCs_Mouse1.55904749
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53378923
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.52649980
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.51927360
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50507703
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.50231312
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.48260047
54EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.47959256
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.47604336
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47121522
57CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.46817192
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46553307
59EWS_26573619_Chip-Seq_HEK293_Human1.45048807
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44922960
61STAT3_23295773_ChIP-Seq_U87_Human1.44133411
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43468211
63SMAD4_21799915_ChIP-Seq_A2780_Human1.43205948
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.42616842
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41316283
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41266879
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.40314256
68VDR_22108803_ChIP-Seq_LS180_Human1.39630152
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35836283
70BCAT_22108803_ChIP-Seq_LS180_Human1.35390556
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.34735162
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.34703709
73ZFX_18555785_Chip-Seq_ESCs_Mouse1.33954529
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33251467
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32659176
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.32393604
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31052644
78AR_25329375_ChIP-Seq_VCAP_Human1.30370502
79KLF4_18555785_Chip-Seq_ESCs_Mouse1.29601781
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29137540
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28315663
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28315663
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.28308560
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28132633
85ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27815914
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27605958
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27308614
88* KDM2B_26808549_Chip-Seq_REH_Human1.26985488
89TCF4_23295773_ChIP-Seq_U87_Human1.26611672
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26204915
91P300_18555785_Chip-Seq_ESCs_Mouse1.25844364
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25426095
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.24419532
94TBL1_22424771_ChIP-Seq_293T_Human1.23530022
95JUN_21703547_ChIP-Seq_K562_Human1.22276787
96* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21420302
97RXR_22108803_ChIP-Seq_LS180_Human1.21130132
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19897372
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.19132991
100* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18747205
101* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18641211
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.17508336
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17443322
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17295114
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17096114
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.16630368
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16133124
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15515655
109PU1_27457419_Chip-Seq_LIVER_Mouse1.15092030
110ER_23166858_ChIP-Seq_MCF-7_Human1.14551721
111AR_21572438_ChIP-Seq_LNCaP_Human1.14548998
112AHR_22903824_ChIP-Seq_MCF-7_Human1.12716655
113RUNX2_22187159_ChIP-Seq_PCA_Human1.12609863
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12562314
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12471439
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.11901068
117* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11676880
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11130428
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11069678
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10930847
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.10862045
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10451254
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.10218318
124CBP_21632823_ChIP-Seq_H3396_Human1.10124884
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10123888
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09188829
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.08646390
128HTT_18923047_ChIP-ChIP_STHdh_Human1.08493922
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08475236
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08149994
131NFYA_21822215_ChIP-Seq_K562_Human1.07522720
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.07318585
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06562425
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05910859
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05520443
136SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04841933
137REST_21632747_ChIP-Seq_MESCs_Mouse1.03991424
138PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03636898
139TAF15_26573619_Chip-Seq_HEK293_Human1.03501377
140GF1_26923725_Chip-Seq_HPCs_Mouse1.01342341
141CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01098504
142ISL1_27105846_Chip-Seq_CPCs_Mouse1.00788203
143FLI1_21867929_ChIP-Seq_CD8_Mouse1.00587135
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.98445529
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97067538
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96331416
147SOX9_26525672_Chip-Seq_HEART_Mouse0.96074262
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94191512
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.92655358
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91088604
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90987563
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.87354298
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87239021
154SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86690061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis7.43524714
2MP0005367_renal/urinary_system_phenotyp5.38559960
3MP0000516_abnormal_urinary_system5.38559960
4MP0005377_hearing/vestibular/ear_phenot5.06354118
5MP0003878_abnormal_ear_physiology5.06354118
6MP0008004_abnormal_stomach_pH5.02945191
7MP0002909_abnormal_adrenal_gland4.84720656
8MP0006292_abnormal_olfactory_placode4.20439301
9MP0003646_muscle_fatigue3.84904982
10MP0002102_abnormal_ear_morphology3.84322126
11MP0000566_synostosis3.36744311
12MP0009697_abnormal_copulation3.19749932
13MP0003718_maternal_effect2.92622670
14MP0005451_abnormal_body_composition2.74868371
15MP0003879_abnormal_hair_cell2.65737178
16MP0005646_abnormal_pituitary_gland2.58532452
17MP0005645_abnormal_hypothalamus_physiol2.27157972
18MP0002638_abnormal_pupillary_reflex2.23568818
19* MP0000678_abnormal_parathyroid_gland11.9354683
20MP0002249_abnormal_larynx_morphology1.98869293
21MP0004742_abnormal_vestibular_system1.95017662
22MP0002735_abnormal_chemical_nociception1.93117642
23MP0001958_emphysema1.92925601
24MP0002163_abnormal_gland_morphology1.92021959
25MP0001485_abnormal_pinna_reflex1.90389648
26MP0003787_abnormal_imprinting1.88253540
27MP0008877_abnormal_DNA_methylation1.86200401
28MP0000733_abnormal_muscle_development1.81247965
29MP0001119_abnormal_female_reproductive1.79401690
30MP0002653_abnormal_ependyma_morphology1.76403902
31MP0010386_abnormal_urinary_bladder1.74389260
32MP0001986_abnormal_taste_sensitivity1.73039146
33MP0006276_abnormal_autonomic_nervous1.71910071
34MP0002736_abnormal_nociception_after1.69487645
35MP0004215_abnormal_myocardial_fiber1.67831707
36MP0004782_abnormal_surfactant_physiolog1.61143036
37MP0005310_abnormal_salivary_gland1.60515598
38MP0006072_abnormal_retinal_apoptosis1.60366491
39MP0003941_abnormal_skin_development1.56239046
40MP0002277_abnormal_respiratory_mucosa1.55760972
41MP0010094_abnormal_chromosome_stability1.52766159
42MP0002896_abnormal_bone_mineralization1.50231173
43MP0003329_amyloid_beta_deposits1.49183661
44MP0002168_other_aberrant_phenotype1.44047978
45MP0005171_absent_coat_pigmentation1.44004899
46MP0002938_white_spotting1.42043098
47MP0003693_abnormal_embryo_hatching1.41484719
48MP0004484_altered_response_of1.39712335
49MP0003656_abnormal_erythrocyte_physiolo1.38241440
50MP0001346_abnormal_lacrimal_gland1.37080603
51MP0001502_abnormal_circadian_rhythm1.33924153
52MP0003699_abnormal_female_reproductive1.33440015
53MP0000383_abnormal_hair_follicle1.31761535
54MP0001529_abnormal_vocalization1.29985084
55MP0005257_abnormal_intraocular_pressure1.28816976
56MP0005395_other_phenotype1.28594999
57MP0002932_abnormal_joint_morphology1.28041316
58MP0000163_abnormal_cartilage_morphology1.28017324
59MP0004019_abnormal_vitamin_homeostasis1.25251813
60MP0002132_abnormal_respiratory_system1.23516072
61MP0001968_abnormal_touch/_nociception1.22497634
62MP0003880_abnormal_central_pattern1.21836472
63MP0005423_abnormal_somatic_nervous1.21705133
64MP0001486_abnormal_startle_reflex1.19563654
65MP0003111_abnormal_nucleus_morphology1.16822904
66MP0003937_abnormal_limbs/digits/tail_de1.15817704
67MP0005551_abnormal_eye_electrophysiolog1.15771273
68MP0002108_abnormal_muscle_morphology1.14479459
69MP0000579_abnormal_nail_morphology1.13707983
70MP0004510_myositis1.13153014
71MP0008260_abnormal_autophagy1.10710182
72MP0003077_abnormal_cell_cycle1.08700320
73* MP0001765_abnormal_ion_homeostasis1.08527977
74MP0002210_abnormal_sex_determination1.06306174
75MP0009840_abnormal_foam_cell1.04966063
76MP0001984_abnormal_olfaction1.03496094
77MP0002396_abnormal_hematopoietic_system0.99600824
78MP0003300_gastrointestinal_ulcer0.97392327
79MP0000653_abnormal_sex_gland0.97334134
80MP0001790_abnormal_immune_system0.94227446
81MP0005387_immune_system_phenotype0.94227446
82MP0005647_abnormal_sex_gland0.92137013
83MP0001963_abnormal_hearing_physiology0.91649264
84MP0003136_yellow_coat_color0.91123873
85MP0008789_abnormal_olfactory_epithelium0.89819658
86MP0003283_abnormal_digestive_organ0.88555123
87MP0002098_abnormal_vibrissa_morphology0.88519674
88MP0005379_endocrine/exocrine_gland_phen0.88127760
89MP0010678_abnormal_skin_adnexa0.87902014
90MP0003121_genomic_imprinting0.87838724
91MP0000778_abnormal_nervous_system0.86006478
92MP0001929_abnormal_gametogenesis0.83201831
93MP0005390_skeleton_phenotype0.82845239
94MP0000026_abnormal_inner_ear0.82332981
95MP0000681_abnormal_thyroid_gland0.82018705
96MP0000569_abnormal_digit_pigmentation0.81698342
97MP0004859_abnormal_synaptic_plasticity0.80409123
98MP0003633_abnormal_nervous_system0.79377626
99MP0001905_abnormal_dopamine_level0.78941030
100MP0002557_abnormal_social/conspecific_i0.78630715
101MP0002572_abnormal_emotion/affect_behav0.78390074
102MP0005394_taste/olfaction_phenotype0.77910893
103MP0005499_abnormal_olfactory_system0.77910893
104MP0004924_abnormal_behavior0.77777881
105MP0005386_behavior/neurological_phenoty0.77777881
106MP0005408_hypopigmentation0.75153086
107MP0010030_abnormal_orbit_morphology0.73726297
108MP0002184_abnormal_innervation0.73594548
109MP0005248_abnormal_Harderian_gland0.72958810
110MP0003186_abnormal_redox_activity0.71812606
111MP0000013_abnormal_adipose_tissue0.71666177
112MP0005253_abnormal_eye_physiology0.70565924
113* MP0009643_abnormal_urine_homeostasis0.69541084
114MP0002233_abnormal_nose_morphology0.69041179
115MP0009250_abnormal_appendicular_skeleto0.68222405
116MP0005389_reproductive_system_phenotype0.68221793
117MP0003938_abnormal_ear_development0.67691319
118MP0002161_abnormal_fertility/fecundity0.65537645
119MP0002127_abnormal_cardiovascular_syste0.63851299
120MP0003763_abnormal_thymus_physiology0.62748400
121MP0008058_abnormal_DNA_repair0.62633948
122MP0003755_abnormal_palate_morphology0.62340260
123MP0001800_abnormal_humoral_immune0.61782981
124* MP0002113_abnormal_skeleton_development0.61666170
125MP0000613_abnormal_salivary_gland0.61197608
126MP0008007_abnormal_cellular_replicative0.61055239
127MP0003950_abnormal_plasma_membrane0.60834158
128MP0005671_abnormal_response_to0.60658660
129MP0000631_abnormal_neuroendocrine_gland0.60337771
130MP0000427_abnormal_hair_cycle0.59966524
131MP0001919_abnormal_reproductive_system0.59825035
132MP0003631_nervous_system_phenotype0.57592032
133MP0002177_abnormal_outer_ear0.57540889
134MP0000470_abnormal_stomach_morphology0.57217338
135MP0003936_abnormal_reproductive_system0.56650145
136MP0002234_abnormal_pharynx_morphology0.56626805
137MP0002063_abnormal_learning/memory/cond0.56390441
138MP0000604_amyloidosis0.55981574
139* MP0003795_abnormal_bone_structure0.55098783
140MP0000639_abnormal_adrenal_gland0.54999652
141MP0001188_hyperpigmentation0.54940974
142MP0001440_abnormal_grooming_behavior0.54852609
143MP0003698_abnormal_male_reproductive0.54331898
144MP0002751_abnormal_autonomic_nervous0.54193285
145MP0003638_abnormal_response/metabolism_0.54181172
146MP0005508_abnormal_skeleton_morphology0.53320271
147MP0002148_abnormal_hypersensitivity_rea0.53287545
148MP0001145_abnormal_male_reproductive0.52929886
149MP0001970_abnormal_pain_threshold0.51952393
150MP0002734_abnormal_mechanical_nocicepti0.51923760
151MP0002067_abnormal_sensory_capabilities0.51452441
152MP0002116_abnormal_craniofacial_bone0.51211575
153MP0004858_abnormal_nervous_system0.50059834
154MP0000049_abnormal_middle_ear0.49199076
155MP0001664_abnormal_digestion0.49171826
156MP0002115_abnormal_skeleton_extremities0.48005156
157MP0000377_abnormal_hair_follicle0.47431763
158MP0003635_abnormal_synaptic_transmissio0.47291794
159MP0009379_abnormal_foot_pigmentation0.46225340
160MP0002064_seizures0.45745680
161MP0009745_abnormal_behavioral_response0.43552832
162MP0003137_abnormal_impulse_conducting0.43294690
163MP0000749_muscle_degeneration0.41935989
164MP0005501_abnormal_skin_physiology0.41477361
165* MP0003935_abnormal_craniofacial_develop0.41459936
166* MP0005636_abnormal_mineral_homeostasis0.40574986
167MP0001270_distended_abdomen0.39628177
168MP0002971_abnormal_brown_adipose0.38935679
169MP0010771_integument_phenotype0.37289307
170MP0000534_abnormal_ureter_morphology0.37087824
171MP0002229_neurodegeneration0.36841666
172MP0002796_impaired_skin_barrier0.36454913
173MP0005166_decreased_susceptibility_to0.35878579
174MP0004270_analgesia0.34782148
175MP0002160_abnormal_reproductive_system0.34585201

Predicted human phenotypes

RankGene SetZ-score
1Alacrima (HP:0000522)7.90353846
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.01173695
3Microretrognathia (HP:0000308)6.74866307
4Decreased lacrimation (HP:0000633)6.59799078
5Parakeratosis (HP:0001036)6.40747962
6Increased circulating renin level (HP:0000848)6.40658695
7Unilateral renal agenesis (HP:0000122)5.93474843
8Nasolacrimal duct obstruction (HP:0000579)5.79425966
9Mixed hearing impairment (HP:0000410)5.40132007
10J-shaped sella turcica (HP:0002680)5.32094870
11Conjugated hyperbilirubinemia (HP:0002908)5.16662038
12Bilateral sensorineural hearing impairment (HP:0008619)5.07903530
13Chromosomal breakage induced by crosslinking agents (HP:0003221)5.06455528
14Alopecia of scalp (HP:0002293)4.97988514
15Abnormal drinking behavior (HP:0030082)4.96476961
16Polydipsia (HP:0001959)4.96476961
17Abnormality of the lacrimal duct (HP:0011481)4.92203123
18Vacuolated lymphocytes (HP:0001922)4.89931052
19Metaphyseal irregularity (HP:0003025)4.89017020
20Preauricular pit (HP:0004467)4.87139407
21Periauricular skin pits (HP:0100277)4.87139407
22Absent eyebrow (HP:0002223)4.79980444
23Chromsome breakage (HP:0040012)4.66109118
24Follicular hyperkeratosis (HP:0007502)4.65609727
25* Hypoparathyroidism (HP:0000829)4.43715840
26Abnormality of dental color (HP:0011073)4.29792191
27Failure to thrive in infancy (HP:0001531)4.26994259
28Abnormality of the nasolacrimal system (HP:0000614)4.20927458
29Absent eyelashes (HP:0000561)4.12495791
30* Abnormality of calcium-phosphate metabolism (HP:0100530)4.10885423
31* Hypocalcemia (HP:0002901)3.88338913
32Cheilitis (HP:0100825)3.76124940
33Hypomagnesemia (HP:0002917)3.64675093
34Scapular winging (HP:0003691)3.64659339
35Dynein arm defect of respiratory motile cilia (HP:0012255)3.48149099
36Absent/shortened dynein arms (HP:0200106)3.48149099
37Retrobulbar optic neuritis (HP:0100654)3.47027509
38Optic neuritis (HP:0100653)3.47027509
39Polyuria (HP:0000103)3.46507400
40Recurrent corneal erosions (HP:0000495)3.44953662
41Ectropion (HP:0000656)3.36412932
42Generalized aminoaciduria (HP:0002909)3.30539968
43Ectopic kidney (HP:0000086)3.29534453
44Skin pits (HP:0100276)3.27113116
45Abnormality of renal excretion (HP:0011036)3.24281032
46Fair hair (HP:0002286)3.23416400
47Abnormality of renal resorption (HP:0011038)3.19233852
48Chronic otitis media (HP:0000389)3.18049841
49Abnormality of the antihelix (HP:0009738)3.17179172
50Abnormality of the costochondral junction (HP:0000919)3.16083316
51Intellectual disability, moderate (HP:0002342)3.15923916
52Hypokalemia (HP:0002900)3.13183563
53Deformed sella turcica (HP:0002681)3.12142951
54Hypergonadotropic hypogonadism (HP:0000815)3.05371935
55Renal Fanconi syndrome (HP:0001994)3.03395894
56Abnormality of magnesium homeostasis (HP:0004921)2.96407529
57Flat capital femoral epiphysis (HP:0003370)2.92043830
58Hyperparathyroidism (HP:0000843)2.91318363
59Abnormal urine output (HP:0012590)2.83432295
60Hypophosphatemic rickets (HP:0004912)2.77668957
61Abnormal ciliary motility (HP:0012262)2.75303620
62Generalized hypopigmentation of hair (HP:0011358)2.73810999
63Abolished electroretinogram (ERG) (HP:0000550)2.73670864
64Keratitis (HP:0000491)2.73497130
65Exotropia (HP:0000577)2.70458917
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.70426310
67Erythroderma (HP:0001019)2.69017703
68Abnormality of the renal collecting system (HP:0004742)2.69003214
69Duplicated collecting system (HP:0000081)2.67938909
70Renal dysplasia (HP:0000110)2.67401962
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58569546
72Pancreatic fibrosis (HP:0100732)2.56277971
73Orchitis (HP:0100796)2.55542301
74Abnormality of the preputium (HP:0100587)2.54565299
75Abnormality of the dental root (HP:0006486)2.52838051
76Taurodontia (HP:0000679)2.52838051
77Abnormality of permanent molar morphology (HP:0011071)2.52838051
78Abnormality of renin-angiotensin system (HP:0000847)2.51629986
79Abnormality of incisor morphology (HP:0011063)2.51375935
80Septo-optic dysplasia (HP:0100842)2.50469073
81Symptomatic seizures (HP:0011145)2.48730590
82Abnormal respiratory motile cilium physiology (HP:0012261)2.47295905
83Hypoplasia of the fovea (HP:0007750)2.45654022
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.45654022
85Fetal akinesia sequence (HP:0001989)2.42195208
86Prostate neoplasm (HP:0100787)2.42066204
87Blepharitis (HP:0000498)2.40391888
88Type 2 muscle fiber atrophy (HP:0003554)2.40156625
89Small epiphyses (HP:0010585)2.38817562
90Chronic hepatic failure (HP:0100626)2.36650218
91Abnormality of molar (HP:0011077)2.35914497
92Abnormality of molar morphology (HP:0011070)2.35914497
93Abnormality of the shoulder girdle musculature (HP:0001435)2.34100295
94Hyperphosphaturia (HP:0003109)2.31585116
95Absent epiphyses (HP:0010577)2.30351167
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.30351167
97Adrenal hypoplasia (HP:0000835)2.29658141
98Inability to walk (HP:0002540)2.28767421
99Meckel diverticulum (HP:0002245)2.27918545
100Hypophosphatemia (HP:0002148)2.27436405
101Congenital sensorineural hearing impairment (HP:0008527)2.25486239
102Pancreatic cysts (HP:0001737)2.23608536
103Rhinitis (HP:0012384)2.22916331
104Abnormality of the dental pulp (HP:0006479)2.21582661
105True hermaphroditism (HP:0010459)2.21020655
106Myositis (HP:0100614)2.20663982
107Thickened calvaria (HP:0002684)2.20059955
108Absent hair (HP:0002298)2.19906611
109Sprengel anomaly (HP:0000912)2.19528510
110Abnormality of potassium homeostasis (HP:0011042)2.19274437
111Rickets (HP:0002748)2.18467077
112Clubbing of toes (HP:0100760)2.15005535
113Melanoma (HP:0002861)2.14393557
114Patellar aplasia (HP:0006443)2.13277997
115Abnormality of the ileum (HP:0001549)2.12507236
116Hypoglycemic seizures (HP:0002173)2.11303639
117Abnormal biliary tract physiology (HP:0012439)2.05461711
118Bile duct proliferation (HP:0001408)2.05461711
119Abnormality of chromosome stability (HP:0003220)2.05089141
120Neoplasm of the lung (HP:0100526)2.04558889
121Abnormal respiratory epithelium morphology (HP:0012253)2.03739692
122Abnormal respiratory motile cilium morphology (HP:0005938)2.03739692
123Febrile seizures (HP:0002373)2.02539905
124Abnormality of the intervertebral disk (HP:0005108)2.00320507
125Absent septum pellucidum (HP:0001331)2.00315229
126* Tetany (HP:0001281)12.8096102
127* Hyperphosphatemia (HP:0002905)12.2288556
128Abnormality of the epiphysis of the femoral head (HP:0010574)1.98742956
129Hypoplastic iliac wings (HP:0002866)1.97047217
130Abnormal hair whorl (HP:0010721)1.95838402
131Midline defect of the nose (HP:0004122)1.95024210
132Abnormality of the fovea (HP:0000493)1.94800128
133Abnormality of the labia minora (HP:0012880)1.94560732
134Male infertility (HP:0003251)1.94477885
135Shawl scrotum (HP:0000049)1.94003313
136Tachypnea (HP:0002789)1.93470765
137Abnormality of the sella turcica (HP:0002679)1.93305036
138Oligohydramnios (HP:0001562)1.92824465
139Capillary hemangiomas (HP:0005306)1.92557898
140Abnormality of DNA repair (HP:0003254)1.90404685
141Nephrocalcinosis (HP:0000121)1.90126558
142Aplasia/Hypoplasia of the patella (HP:0006498)1.89996393
143Abnormal urine phosphate concentration (HP:0012599)1.89215810
144Muscle fiber atrophy (HP:0100295)1.88288333
145Astigmatism (HP:0000483)1.88068871
146Arthropathy (HP:0003040)1.87976818
147Chronic sinusitis (HP:0011109)1.87627442
148Abnormality of the femoral head (HP:0003368)1.87406167
149Athetosis (HP:0002305)1.86732799
150Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.83663690
151Abnormality of femoral epiphyses (HP:0006499)1.83663690
152Atresia of the external auditory canal (HP:0000413)1.82181876
153Aplasia of the musculature (HP:0100854)1.82179889
154Renal agenesis (HP:0000104)1.81516438
155Increased serum pyruvate (HP:0003542)1.77940736
156Osteomalacia (HP:0002749)1.77711806
157Abnormality of alanine metabolism (HP:0010916)1.76881448
158Hyperalaninemia (HP:0003348)1.76881448
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76881448
160Abnormality of the carotid arteries (HP:0005344)1.76549019
161Abnormality of the septum pellucidum (HP:0007375)1.76339994
162Birth length less than 3rd percentile (HP:0003561)1.75223996
163Hypercalciuria (HP:0002150)1.73532757
164Delayed puberty (HP:0000823)1.73516254
165Hyperactive renin-angiotensin system (HP:0000841)1.73235931
166Keratoconjunctivitis sicca (HP:0001097)1.72005992
167Tapered finger (HP:0001182)1.71477819
168Neoplasm of the respiratory system (HP:0100606)1.68778746
169Abnormality of the prostate (HP:0008775)1.67116150
170Absent radius (HP:0003974)1.65749335
171Absent forearm bone (HP:0003953)1.65083704
172Aplasia involving forearm bones (HP:0009822)1.65083704
173Aganglionic megacolon (HP:0002251)1.63174846
174Progressive neurologic deterioration (HP:0002344)1.60248470
175Abnormality of glycolysis (HP:0004366)1.60227562
176Vascular calcification (HP:0004934)1.58421679
177Hyponatremia (HP:0002902)1.56820100
178Death in childhood (HP:0003819)1.52181104
179Gait imbalance (HP:0002141)1.52021350
180Focal seizures (HP:0007359)1.49926365
181Congenital primary aphakia (HP:0007707)1.47491427
182Genital tract atresia (HP:0001827)1.43780256
183Tetraparesis (HP:0002273)1.43182506
184Rough bone trabeculation (HP:0100670)1.43074079
185Intrahepatic cholestasis (HP:0001406)1.40908718
186Vaginal atresia (HP:0000148)1.39455078
187Scanning speech (HP:0002168)1.39400704
188Basal ganglia calcification (HP:0002135)1.38095009
189Anosmia (HP:0000458)1.34286177
190Bundle branch block (HP:0011710)1.33486330
191Syncope (HP:0001279)1.32907453
192Oligodontia (HP:0000677)1.32758631
193Abnormality of fatty-acid metabolism (HP:0004359)1.32436217
194Portal hypertension (HP:0001409)1.32126983
195Deep venous thrombosis (HP:0002625)1.31383881
196Infertility (HP:0000789)1.30548206
197Myokymia (HP:0002411)1.29844776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K37.08380590
2PDK26.93647828
3SIK36.37643280
4MAP4K24.94693571
5SCYL24.50054116
6FLT34.03000024
7STK38L3.48559844
8SIK23.47407747
9LATS13.39296878
10MAP3K62.77555004
11MARK32.60812872
12LATS22.55191023
13SIK12.51798152
14PRKG22.39499239
15CASK2.37779589
16PLK42.33699339
17CDK82.30570645
18BRAF2.00948312
19MUSK1.96873479
20MAP2K71.95462289
21KIT1.94353846
22MAPK131.90646890
23TTK1.82956821
24CSF1R1.82413967
25BMPR21.80843927
26TAOK31.76153240
27MAP3K131.62925717
28ERBB41.60143594
29TXK1.59454985
30PRPF4B1.59266319
31SGK21.55006988
32BLK1.52857601
33PRKCG1.47664005
34NEK61.43728336
35TIE11.43144062
36RIPK11.33183934
37EPHA21.30634202
38EEF2K1.29336993
39STK31.29083252
40ZAK1.25494703
41CHEK21.24136814
42MARK11.23241545
43BMPR1B1.20372663
44MAP3K41.16881148
45MARK21.09273998
46KSR21.08173903
47RET1.06439807
48CDK31.05560357
49JAK31.04111245
50PRKD31.02391415
51STK381.01740749
52KSR11.00029342
53AKT30.96919744
54SGK2230.93977075
55SGK4940.93977075
56PAK60.93466203
57MOS0.91057049
58MKNK10.89756931
59CDK90.88602152
60MAP3K120.87879364
61MAP2K40.85892167
62DYRK20.85070338
63GSK3A0.82170966
64ADRBK20.81840846
65TRPM70.81616521
66NEK20.79659640
67VRK10.79589899
68MAP3K10.79038761
69MAPK150.77153665
70RAF10.75945927
71MKNK20.74442155
72EPHA40.72634542
73MAPK70.71576392
74SGK30.71521148
75PRKAA20.71465872
76BCKDK0.71444592
77NTRK20.71190426
78CDC70.69433878
79PRKAA10.68844269
80MAP3K50.66902434
81MET0.66856795
82MST40.65692177
83MELK0.65262367
84CSNK1A10.65065964
85EPHB20.65009490
86STK100.64138687
87MAP3K90.63300865
88TAOK20.62980247
89FGR0.62053901
90TNIK0.61779253
91MAPK40.61774362
92PAK40.61732578
93ADRBK10.61557890
94PLK20.61494516
95MINK10.60298237
96PRKD20.57780695
97EIF2AK20.57666572
98PINK10.57446312
99TEC0.56527068
100CAMK2D0.56167333
101MAPK120.55779886
102WNK30.55553901
103PKN10.55365286
104EIF2AK10.55121467
105PRKD10.55046234
106ZAP700.54368715
107PLK30.51987487
108NLK0.51846425
109YES10.51547055
110NUAK10.50728297
111TESK20.49905754
112MAPK110.49123836
113CAMK40.48465905
114PAK30.47266541
115PHKG20.47076161
116PHKG10.47076161
117INSRR0.46942343
118MAPKAPK50.46367889
119MAPKAPK30.45284078
120PLK10.42355309
121MYLK0.42016539
122CSNK1D0.41844459
123STK240.41825387
124CDK70.41638579
125TAOK10.40926674
126PAK20.39371068
127PRKACA0.37939262
128ERBB20.37599793
129PDK10.37532591
130MAP3K70.37322821
131MAP3K140.37012681
132CAMK2A0.35686762
133GRK10.35577281
134STK160.34920290
135PRKCE0.34476031
136PRKCQ0.34036822
137CSNK1E0.33980252
138BCR0.33497987
139CSNK1G10.33422645
140PDPK10.33091554
141ACVR1B0.32982360
142CAMK1D0.32595704
143PRKCB0.32075793
144MAPK30.31091975
145MAP2K10.30657618
146CAMKK20.30389362
147NTRK30.30327410
148OBSCN0.30154089
149ICK0.29850482
150PIM20.29489994
151CHEK10.29440183
152DYRK1A0.29135449
153WNK40.29121320
154CSNK1G20.27764320
155CAMK10.27646529
156PRKCA0.27217384
157ATR0.25668008
158RPS6KA40.25372400
159PDGFRA0.24881031
160ROCK10.24591007
161ABL20.24290607
162EPHA30.23596623
163TYK20.23193357
164IKBKE0.22475250
165AKT20.21926886
166CAMK2G0.20552083
167MAPK10.20381128
168PAK10.20360383

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049645.18521380
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.22846298
3Phototransduction_Homo sapiens_hsa047443.22702356
4Gastric acid secretion_Homo sapiens_hsa049712.93400835
5Fatty acid biosynthesis_Homo sapiens_hsa000612.90988643
6Ovarian steroidogenesis_Homo sapiens_hsa049132.73833236
7Basal transcription factors_Homo sapiens_hsa030222.52711545
8Vitamin B6 metabolism_Homo sapiens_hsa007502.43868392
9Circadian rhythm_Homo sapiens_hsa047102.42422469
10Cell cycle_Homo sapiens_hsa041102.33422789
11Nicotine addiction_Homo sapiens_hsa050332.30048192
12Fanconi anemia pathway_Homo sapiens_hsa034602.24984016
13Salivary secretion_Homo sapiens_hsa049702.20394567
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.14903319
15RNA degradation_Homo sapiens_hsa030181.92647487
16Bile secretion_Homo sapiens_hsa049761.80547003
17Homologous recombination_Homo sapiens_hsa034401.78124416
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77943984
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70590611
20Protein digestion and absorption_Homo sapiens_hsa049741.66483732
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63057603
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.59051762
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58422387
24Arginine biosynthesis_Homo sapiens_hsa002201.57833929
25GABAergic synapse_Homo sapiens_hsa047271.56196431
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55692281
27Autoimmune thyroid disease_Homo sapiens_hsa053201.54627087
28Primary immunodeficiency_Homo sapiens_hsa053401.53051911
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42519513
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42420957
31Serotonergic synapse_Homo sapiens_hsa047261.40875336
32Mineral absorption_Homo sapiens_hsa049781.40874397
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40855154
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.40795528
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40689029
36Ether lipid metabolism_Homo sapiens_hsa005651.39547949
37Fatty acid metabolism_Homo sapiens_hsa012121.38973271
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35834195
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.33508177
40Thyroid hormone synthesis_Homo sapiens_hsa049181.33164557
41Linoleic acid metabolism_Homo sapiens_hsa005911.30694156
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28742136
43Insulin secretion_Homo sapiens_hsa049111.27595147
44Nitrogen metabolism_Homo sapiens_hsa009101.24721792
45Measles_Homo sapiens_hsa051621.24335353
46Renin secretion_Homo sapiens_hsa049241.22154631
47Rheumatoid arthritis_Homo sapiens_hsa053231.21945157
48Herpes simplex infection_Homo sapiens_hsa051681.21652329
49Graft-versus-host disease_Homo sapiens_hsa053321.21419847
50Regulation of autophagy_Homo sapiens_hsa041401.21269222
51p53 signaling pathway_Homo sapiens_hsa041151.20634793
52Complement and coagulation cascades_Homo sapiens_hsa046101.20589489
53Morphine addiction_Homo sapiens_hsa050321.19730377
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17340397
55Renal cell carcinoma_Homo sapiens_hsa052111.16807467
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15891141
57Pancreatic cancer_Homo sapiens_hsa052121.15075761
58Taste transduction_Homo sapiens_hsa047421.14687855
59Hematopoietic cell lineage_Homo sapiens_hsa046401.13749997
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12818382
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10999575
62Cardiac muscle contraction_Homo sapiens_hsa042601.10367813
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09246583
64Choline metabolism in cancer_Homo sapiens_hsa052311.06462216
65Prolactin signaling pathway_Homo sapiens_hsa049171.03696757
66Pancreatic secretion_Homo sapiens_hsa049721.03202717
67NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02157164
68Adipocytokine signaling pathway_Homo sapiens_hsa049201.01508637
69Melanoma_Homo sapiens_hsa052180.99490112
70Fatty acid elongation_Homo sapiens_hsa000620.98503384
71Allograft rejection_Homo sapiens_hsa053300.98239505
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96809938
73TNF signaling pathway_Homo sapiens_hsa046680.96603340
74Lysosome_Homo sapiens_hsa041420.91964960
75TGF-beta signaling pathway_Homo sapiens_hsa043500.91754404
76Gap junction_Homo sapiens_hsa045400.91539483
77Ras signaling pathway_Homo sapiens_hsa040140.90463495
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.89193441
79N-Glycan biosynthesis_Homo sapiens_hsa005100.88667311
80Glutamatergic synapse_Homo sapiens_hsa047240.88354981
81PPAR signaling pathway_Homo sapiens_hsa033200.87378340
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87375032
83FoxO signaling pathway_Homo sapiens_hsa040680.87258153
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86819205
85Notch signaling pathway_Homo sapiens_hsa043300.86079384
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85727610
87ErbB signaling pathway_Homo sapiens_hsa040120.85657777
88Tuberculosis_Homo sapiens_hsa051520.84568795
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83742404
90Cocaine addiction_Homo sapiens_hsa050300.83306272
91Base excision repair_Homo sapiens_hsa034100.82217983
92Starch and sucrose metabolism_Homo sapiens_hsa005000.80977885
93Calcium signaling pathway_Homo sapiens_hsa040200.80752579
94Influenza A_Homo sapiens_hsa051640.79900579
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79770424
96RNA polymerase_Homo sapiens_hsa030200.79240506
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77940024
98Axon guidance_Homo sapiens_hsa043600.76459125
99Arachidonic acid metabolism_Homo sapiens_hsa005900.76314645
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74979632
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73603770
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72983525
103GnRH signaling pathway_Homo sapiens_hsa049120.72862290
104Hepatitis B_Homo sapiens_hsa051610.72620878
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72616663
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.72351464
107Sphingolipid metabolism_Homo sapiens_hsa006000.70142291
108Synaptic vesicle cycle_Homo sapiens_hsa047210.69951382
109Long-term depression_Homo sapiens_hsa047300.68877087
110ECM-receptor interaction_Homo sapiens_hsa045120.68206631
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.68018259
112MicroRNAs in cancer_Homo sapiens_hsa052060.67689174
113Malaria_Homo sapiens_hsa051440.65689662
114Type I diabetes mellitus_Homo sapiens_hsa049400.64743383
115Dorso-ventral axis formation_Homo sapiens_hsa043200.62153047
116HTLV-I infection_Homo sapiens_hsa051660.61541996
117Adherens junction_Homo sapiens_hsa045200.61533497
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60950858
119Leishmaniasis_Homo sapiens_hsa051400.60465749
120T cell receptor signaling pathway_Homo sapiens_hsa046600.58967856
121Wnt signaling pathway_Homo sapiens_hsa043100.58688624
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58483344
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58462674
124Steroid biosynthesis_Homo sapiens_hsa001000.58416318
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57966130
126African trypanosomiasis_Homo sapiens_hsa051430.57338740
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57166879
128MAPK signaling pathway_Homo sapiens_hsa040100.56712172
129Purine metabolism_Homo sapiens_hsa002300.56518508
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56249046
131Dilated cardiomyopathy_Homo sapiens_hsa054140.55408712
132Hedgehog signaling pathway_Homo sapiens_hsa043400.54308625
133Tight junction_Homo sapiens_hsa045300.53881133
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.50543091
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50444789
136Oocyte meiosis_Homo sapiens_hsa041140.50258771
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49888104
138Olfactory transduction_Homo sapiens_hsa047400.49625624
139Inositol phosphate metabolism_Homo sapiens_hsa005620.49444215
140Collecting duct acid secretion_Homo sapiens_hsa049660.49408628
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48757192
142Chemokine signaling pathway_Homo sapiens_hsa040620.48715784
143Vibrio cholerae infection_Homo sapiens_hsa051100.48000646
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46842335
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46781694
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46510217
147Osteoclast differentiation_Homo sapiens_hsa043800.46363644
148Dopaminergic synapse_Homo sapiens_hsa047280.46069391
149Hippo signaling pathway_Homo sapiens_hsa043900.45517508
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44203058
151Fatty acid degradation_Homo sapiens_hsa000710.43085233
152cAMP signaling pathway_Homo sapiens_hsa040240.42730058
153Circadian entrainment_Homo sapiens_hsa047130.42259115
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37810901
155Renin-angiotensin system_Homo sapiens_hsa046140.37247206
156Platelet activation_Homo sapiens_hsa046110.37240095
157Butanoate metabolism_Homo sapiens_hsa006500.36409737
158Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36084879
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34896818
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32007610
161Peroxisome_Homo sapiens_hsa041460.28520295
162Metabolic pathways_Homo sapiens_hsa011000.27976292
163Fat digestion and absorption_Homo sapiens_hsa049750.26743863
164Glucagon signaling pathway_Homo sapiens_hsa049220.24901905
165Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22325301
166Oxytocin signaling pathway_Homo sapiens_hsa049210.22158549
167Rap1 signaling pathway_Homo sapiens_hsa040150.20991996
168Protein export_Homo sapiens_hsa030600.16463468
169Long-term potentiation_Homo sapiens_hsa047200.14417921
170Staphylococcus aureus infection_Homo sapiens_hsa051500.13953219

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