GCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.23162511
2nuclear pore organization (GO:0006999)5.26697937
3DNA unwinding involved in DNA replication (GO:0006268)5.21456378
4mitotic chromosome condensation (GO:0007076)4.76941224
5regulation of translational fidelity (GO:0006450)4.73637116
6COPI coating of Golgi vesicle (GO:0048205)4.67270436
7Golgi transport vesicle coating (GO:0048200)4.67270436
8pore complex assembly (GO:0046931)4.49370206
9regulation of RNA export from nucleus (GO:0046831)3.96573364
10proline biosynthetic process (GO:0006561)3.83139077
11spliceosomal tri-snRNP complex assembly (GO:0000244)3.78853475
12regulation of histone H3-K27 methylation (GO:0061085)3.62091173
13focal adhesion assembly (GO:0048041)3.55497312
14cell-substrate adherens junction assembly (GO:0007045)3.55497312
15adherens junction assembly (GO:0034333)3.55310868
16mitotic sister chromatid segregation (GO:0000070)3.53527041
17regulation of nucleobase-containing compound transport (GO:0032239)3.49742051
18heterochromatin organization (GO:0070828)3.49612164
19DNA duplex unwinding (GO:0032508)3.48269506
20cellular protein complex localization (GO:0034629)3.46127987
21protein complex localization (GO:0031503)3.42822692
22mitotic sister chromatid cohesion (GO:0007064)3.42078182
23mitotic nuclear envelope disassembly (GO:0007077)3.41266340
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.38561270
25sister chromatid segregation (GO:0000819)3.36570873
26DNA replication initiation (GO:0006270)3.36255247
27activation of Rac GTPase activity (GO:0032863)3.29981626
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27989067
29regulation of NFAT protein import into nucleus (GO:0051532)3.25554494
30membrane disassembly (GO:0030397)3.25475795
31nuclear envelope disassembly (GO:0051081)3.25475795
32DNA geometric change (GO:0032392)3.23727213
33protein export from nucleus (GO:0006611)3.20681043
34cell-substrate junction assembly (GO:0007044)3.19313670
35DNA strand elongation involved in DNA replication (GO:0006271)3.17162175
36DNA strand elongation (GO:0022616)3.11316118
37formation of translation preinitiation complex (GO:0001731)3.05075134
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04710496
39positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.04704456
40RNA stabilization (GO:0043489)3.00852198
41mRNA stabilization (GO:0048255)3.00852198
42regulation of glucose import in response to insulin stimulus (GO:2001273)2.99455161
43apoptotic process involved in morphogenesis (GO:0060561)2.99046643
44negative regulation of cell size (GO:0045792)2.99007906
45chromosome condensation (GO:0030261)2.97512284
46protein-DNA complex disassembly (GO:0032986)2.96129918
47nucleosome disassembly (GO:0006337)2.96129918
48protein localization to chromosome, centromeric region (GO:0071459)2.95707391
49peptidyl-lysine dimethylation (GO:0018027)2.94409663
50cellular response to epidermal growth factor stimulus (GO:0071364)2.89846863
51nuclear envelope organization (GO:0006998)2.89746077
52DNA conformation change (GO:0071103)2.88718538
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87627410
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.86895662
55glucocorticoid receptor signaling pathway (GO:0042921)2.86396460
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86209997
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82845383
58DNA topological change (GO:0006265)2.81369304
59regulation of translational termination (GO:0006449)2.80019515
60protein retention in ER lumen (GO:0006621)2.78963526
61hemidesmosome assembly (GO:0031581)2.78000789
62negative regulation of DNA repair (GO:0045738)2.77973045
63pentose-phosphate shunt (GO:0006098)2.74571100
64pre-miRNA processing (GO:0031054)2.74429709
65regulation of mitotic spindle organization (GO:0060236)2.73519044
66embryonic process involved in female pregnancy (GO:0060136)2.71495544
67maternal placenta development (GO:0001893)2.70440491
68peptidyl-arginine omega-N-methylation (GO:0035247)2.69474763
69negative regulation of histone methylation (GO:0031061)2.69421351
70activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65135331
71positive regulation of nuclease activity (GO:0032075)2.63413652
72DNA synthesis involved in DNA repair (GO:0000731)2.63286820
73COPII vesicle coating (GO:0048208)2.62491889
74response to epidermal growth factor (GO:0070849)2.58885250
75chromatin assembly (GO:0031497)2.58159871
76protein localization to microtubule (GO:0035372)2.57957354
77protein localization to endosome (GO:0036010)2.56716442
78regulation of sister chromatid cohesion (GO:0007063)2.56399509
79histone H3-K36 demethylation (GO:0070544)2.56139594
80positive regulation of DNA-dependent DNA replication (GO:2000105)2.54217250
81desmosome organization (GO:0002934)2.53178679
82epithelial cell-cell adhesion (GO:0090136)2.51215129
83protein localization to kinetochore (GO:0034501)2.49935929
84DNA packaging (GO:0006323)2.49838680
85snRNA metabolic process (GO:0016073)2.49291265
86telomere maintenance via semi-conservative replication (GO:0032201)2.48631543
87regulation of early endosome to late endosome transport (GO:2000641)2.48541845
88vesicle coating (GO:0006901)2.48262667
89proline metabolic process (GO:0006560)2.47542962
90glucose catabolic process (GO:0006007)2.47508152
913-UTR-mediated mRNA stabilization (GO:0070935)2.45989164
92mitotic G1 DNA damage checkpoint (GO:0031571)2.45876471
93positive regulation of cell cycle checkpoint (GO:1901978)2.45764241
94endoplasmic reticulum unfolded protein response (GO:0030968)2.43925062
95mitochondrial DNA metabolic process (GO:0032042)2.43013605
96branching involved in mammary gland duct morphogenesis (GO:0060444)2.42952644
97folic acid-containing compound biosynthetic process (GO:0009396)2.42461447
98regulation of DNA damage checkpoint (GO:2000001)2.42375854
99NADPH regeneration (GO:0006740)2.41869630
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.41643378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.92546787
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.56459996
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.27895507
4MYC_22102868_ChIP-Seq_BL_Human3.02649526
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88545441
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77254620
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.73547089
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.54094372
9ZNF263_19887448_ChIP-Seq_K562_Human2.40591378
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30743661
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12571264
12VDR_21846776_ChIP-Seq_THP-1_Human2.07640172
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05485516
14AR_21909140_ChIP-Seq_LNCAP_Human1.98977277
15MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96707726
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96637485
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.95357820
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94436602
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.90918229
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84912319
21RACK7_27058665_Chip-Seq_MCF-7_Human1.83622962
22ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74248199
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73761327
24TCF7_22412390_ChIP-Seq_EML_Mouse1.71850030
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71118170
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69109722
27CLOCK_20551151_ChIP-Seq_293T_Human1.67572512
28LXR_22292898_ChIP-Seq_THP-1_Human1.67385108
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64360610
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62687865
31CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.59903728
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59567267
33XRN2_22483619_ChIP-Seq_HELA_Human1.58792225
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.58355322
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57736683
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57365350
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55596952
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55059230
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54432888
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50911291
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49232952
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49071708
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47207151
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46909288
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44246164
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43050434
47KDM2B_26808549_Chip-Seq_DND41_Human1.40093644
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37857643
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36262384
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35582936
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34814020
52ATF3_27146783_Chip-Seq_COLON_Human1.33174811
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31616937
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30436427
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28677505
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26438257
57CHD1_26751641_Chip-Seq_LNCaP_Human1.24789540
58NCOR1_26117541_ChIP-Seq_K562_Human1.23419593
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23077049
60KDM5A_27292631_Chip-Seq_BREAST_Human1.21988995
61KDM2B_26808549_Chip-Seq_K562_Human1.21860959
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21572355
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20850329
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20412502
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18980299
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16750265
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13610118
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11556546
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10749658
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10716497
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10121237
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09722214
73DCP1A_22483619_ChIP-Seq_HELA_Human1.09396262
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08804972
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.08298991
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06862916
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.04907439
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04812589
79MAF_26560356_Chip-Seq_TH1_Human1.04452667
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04295405
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03585875
82CIITA_25753668_ChIP-Seq_RAJI_Human1.02792578
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02784227
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.02537567
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01569577
86CREB1_26743006_Chip-Seq_LNCaP_Human1.01521854
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00945190
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00915862
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.99568445
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99518880
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98448703
92TP53_22127205_ChIP-Seq_IMR90_Human0.98262368
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97962308
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.97829658
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97177608
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96954113
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96945118
98RUNX1_27514584_Chip-Seq_MCF-7_Human0.96681521
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96305261
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96196793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.16920451
2MP0005076_abnormal_cell_differentiation2.96289884
3MP0003111_abnormal_nucleus_morphology2.80957316
4MP0010234_abnormal_vibrissa_follicle2.70820809
5MP0005451_abnormal_body_composition2.65288127
6MP0010352_gastrointestinal_tract_polyps2.50709800
7MP0004185_abnormal_adipocyte_glucose2.50519405
8MP0002877_abnormal_melanocyte_morpholog2.45483283
9MP0004233_abnormal_muscle_weight2.44569036
10MP0010094_abnormal_chromosome_stability2.39145980
11MP0003566_abnormal_cell_adhesion2.37632175
12MP0004957_abnormal_blastocyst_morpholog2.32672913
13MP0003693_abnormal_embryo_hatching2.31543302
14MP0008057_abnormal_DNA_replication2.25850967
15MP0000537_abnormal_urethra_morphology2.20341386
16MP0008438_abnormal_cutaneous_collagen2.14052590
17MP0001730_embryonic_growth_arrest2.12772750
18MP0003077_abnormal_cell_cycle2.07808791
19MP0001849_ear_inflammation2.05675238
20MP0002009_preneoplasia1.84503025
21MP0001661_extended_life_span1.73799498
22MP0004272_abnormal_basement_membrane1.71753378
23MP0000350_abnormal_cell_proliferation1.71714352
24MP0002396_abnormal_hematopoietic_system1.68462897
25MP0005380_embryogenesis_phenotype1.62807907
26MP0001672_abnormal_embryogenesis/_devel1.62807907
27MP0003984_embryonic_growth_retardation1.61769836
28MP0008932_abnormal_embryonic_tissue1.61186012
29MP0009672_abnormal_birth_weight1.61160699
30MP0002796_impaired_skin_barrier1.54291474
31MP0002088_abnormal_embryonic_growth/wei1.53805113
32MP0004808_abnormal_hematopoietic_stem1.51850513
33MP0003453_abnormal_keratinocyte_physiol1.49434571
34MP0004264_abnormal_extraembryonic_tissu1.48569034
35MP0002080_prenatal_lethality1.46897447
36MP0002086_abnormal_extraembryonic_tissu1.46312846
37MP0005409_darkened_coat_color1.46179276
38MP0004858_abnormal_nervous_system1.46085481
39MP0000733_abnormal_muscle_development1.42233892
40MP0003091_abnormal_cell_migration1.38731562
41MP0005501_abnormal_skin_physiology1.38722697
42MP0010307_abnormal_tumor_latency1.36673472
43MP0002060_abnormal_skin_morphology1.33564223
44MP0000003_abnormal_adipose_tissue1.33059165
45MP0001697_abnormal_embryo_size1.32661811
46MP0010030_abnormal_orbit_morphology1.29927721
47MP0003941_abnormal_skin_development1.29017732
48MP0005257_abnormal_intraocular_pressure1.28898834
49MP0005666_abnormal_adipose_tissue1.27819080
50MP0002085_abnormal_embryonic_tissue1.26433431
51MP0002089_abnormal_postnatal_growth/wei1.26217960
52MP0002084_abnormal_developmental_patter1.26127142
53MP0001348_abnormal_lacrimal_gland1.25575021
54MP0005623_abnormal_meninges_morphology1.22935598
55MP0008007_abnormal_cellular_replicative1.21603301
56MP0000678_abnormal_parathyroid_gland1.19319105
57MP0004197_abnormal_fetal_growth/weight/1.18250323
58MP0005621_abnormal_cell_physiology1.14948937
59MP0008260_abnormal_autophagy1.13091427
60MP0005375_adipose_tissue_phenotype1.10605563
61MP0001915_intracranial_hemorrhage1.07652625
62MP0000751_myopathy1.03365740
63MP0010630_abnormal_cardiac_muscle1.02569231
64MP0000428_abnormal_craniofacial_morphol1.02375932
65MP0003115_abnormal_respiratory_system1.02036079
66MP0002166_altered_tumor_susceptibility1.01772270
67MP0002697_abnormal_eye_size1.01205730
68MP0003315_abnormal_perineum_morphology1.00689406
69MP0000566_synostosis1.00313092
70MP0005058_abnormal_lysosome_morphology1.00040993
71MP0001216_abnormal_epidermal_layer0.98058572
72MP0000313_abnormal_cell_death0.97997478
73MP0005023_abnormal_wound_healing0.95707812
74MP0000747_muscle_weakness0.95213828
75MP0001873_stomach_inflammation0.94832668
76MP0004087_abnormal_muscle_fiber0.94075912
77MP0000759_abnormal_skeletal_muscle0.92734517
78MP0000490_abnormal_crypts_of0.92603203
79MP0003942_abnormal_urinary_system0.91988799
80MP0000579_abnormal_nail_morphology0.91289945
81MP0003385_abnormal_body_wall0.88427914
82MP0005384_cellular_phenotype0.87761120
83MP0002269_muscular_atrophy0.85992065
84MP0009278_abnormal_bone_marrow0.85566803
85MP0009703_decreased_birth_body0.84503277
86MP0002249_abnormal_larynx_morphology0.83442288
87MP0000762_abnormal_tongue_morphology0.82098206
88MP0009053_abnormal_anal_canal0.81940311
89MP0000377_abnormal_hair_follicle0.81223533
90MP0000467_abnormal_esophagus_morphology0.79744314
91MP0002092_abnormal_eye_morphology0.79467800
92MP0002006_tumorigenesis0.77131623
93MP0003123_paternal_imprinting0.77120586
94MP0002925_abnormal_cardiovascular_devel0.76954653
95MP0000432_abnormal_head_morphology0.76522413
96MP0003763_abnormal_thymus_physiology0.76295010
97MP0002098_abnormal_vibrissa_morphology0.76063696
98MP0009931_abnormal_skin_appearance0.75308891
99MP0000627_abnormal_mammary_gland0.75255623
100MP0000858_altered_metastatic_potential0.74717474

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.67606827
2Premature rupture of membranes (HP:0001788)2.96776967
3Broad face (HP:0000283)2.91145261
4Protrusio acetabuli (HP:0003179)2.86754259
5Ulnar bowing (HP:0003031)2.86322158
6Flat acetabular roof (HP:0003180)2.71070602
7Increased connective tissue (HP:0009025)2.57012575
8Ankyloglossia (HP:0010296)2.54964612
9Dysmetric saccades (HP:0000641)2.54119652
10Distal lower limb amyotrophy (HP:0008944)2.51658781
11Disproportionate tall stature (HP:0001519)2.51509186
12Asymmetry of the thorax (HP:0001555)2.49614224
13Abnormality of oral frenula (HP:0000190)2.39552271
14Insomnia (HP:0100785)2.37765335
15Selective tooth agenesis (HP:0001592)2.35561928
16Abnormality of the distal phalanx of the thumb (HP:0009617)2.34691009
17Abnormality of the fingertips (HP:0001211)2.33160680
18Deviation of the thumb (HP:0009603)2.29458493
19Cerebral aneurysm (HP:0004944)2.26438052
20Advanced eruption of teeth (HP:0006288)2.24801604
21Short nail (HP:0001799)2.22950206
22Long palpebral fissure (HP:0000637)2.22608680
23Abnormality of the calcaneus (HP:0008364)2.20532421
24Shallow orbits (HP:0000586)2.20106600
25Achilles tendon contracture (HP:0001771)2.18731154
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18455007
27Trismus (HP:0000211)2.14911772
28Increased nuchal translucency (HP:0010880)2.13759950
29Sparse lateral eyebrow (HP:0005338)2.12109135
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.11629384
31Progressive muscle weakness (HP:0003323)2.07875119
32Long eyelashes (HP:0000527)2.05722909
33Proximal placement of thumb (HP:0009623)2.02756935
34Chromsome breakage (HP:0040012)2.01337311
35Osteolytic defects of the phalanges of the hand (HP:0009771)1.97925297
36Osteolytic defects of the hand bones (HP:0009699)1.97925297
37Vertebral compression fractures (HP:0002953)1.96782867
38Abnormality of the Achilles tendon (HP:0005109)1.96266014
39Heterotopia (HP:0002282)1.96126524
40Natal tooth (HP:0000695)1.92636593
41Overlapping toe (HP:0001845)1.92253110
42Fragile skin (HP:0001030)1.91930656
43Abnormality of the distal phalanges of the toes (HP:0010182)1.91876613
44Patellar dislocation (HP:0002999)1.90536086
45Progressive external ophthalmoplegia (HP:0000590)1.90182944
46Urethral obstruction (HP:0000796)1.89399256
47Dislocated radial head (HP:0003083)1.89090524
48Elfin facies (HP:0004428)1.88825213
49Biconcave vertebral bodies (HP:0004586)1.88683120
50Reticulocytosis (HP:0001923)1.87681236
51Distal upper limb amyotrophy (HP:0007149)1.85537030
52Upper limb amyotrophy (HP:0009129)1.85537030
53Spinal rigidity (HP:0003306)1.85334453
54Abnormal ossification of hand bones (HP:0005921)1.82250900
55Cervical subluxation (HP:0003308)1.82111702
56Renal duplication (HP:0000075)1.81705351
57Mitral valve prolapse (HP:0001634)1.79154588
58Septate vagina (HP:0001153)1.79064362
59Lower limb amyotrophy (HP:0007210)1.78760946
60Missing ribs (HP:0000921)1.76210512
61High anterior hairline (HP:0009890)1.76008405
62Spinal cord lesions (HP:0100561)1.75186494
63Syringomyelia (HP:0003396)1.75186494
6411 pairs of ribs (HP:0000878)1.75186338
65Deep philtrum (HP:0002002)1.75034799
66Overriding aorta (HP:0002623)1.74437029
67Premature skin wrinkling (HP:0100678)1.73960355
68Back pain (HP:0003418)1.73399142
69Termporal pattern (HP:0011008)1.73245275
70Insidious onset (HP:0003587)1.73245275
71Abnormality of the thoracic spine (HP:0100711)1.72651481
72Relative macrocephaly (HP:0004482)1.72458330
73Abnormality of the radial head (HP:0003995)1.72207886
74Cholecystitis (HP:0001082)1.70821952
75Abnormal gallbladder physiology (HP:0012438)1.70821952
76Thin bony cortex (HP:0002753)1.70588163
77Deep palmar crease (HP:0006191)1.70186742
78Abnormality of carpal bone ossification (HP:0006257)1.69640478
79Vertebral arch anomaly (HP:0008438)1.69613853
80Abnormal foot bone ossification (HP:0010675)1.67868009
81Pointed chin (HP:0000307)1.67841967
82Persistence of primary teeth (HP:0006335)1.65082967
83Elbow flexion contracture (HP:0002987)1.64067558
84Subacute progressive viral hepatitis (HP:0006572)1.63625935
85Wormian bones (HP:0002645)1.62991289
86Blue sclerae (HP:0000592)1.62500729
87Sandal gap (HP:0001852)1.61683736
88Thin ribs (HP:0000883)1.61674736
89Ankle contracture (HP:0006466)1.60112360
90Arnold-Chiari malformation (HP:0002308)1.59675335
91Skull defect (HP:0001362)1.59455690
92Mitral regurgitation (HP:0001653)1.58844767
93Mildly elevated creatine phosphokinase (HP:0008180)1.57490103
94Bladder diverticulum (HP:0000015)1.57169772
95Abnormality of the phalanges of the hallux (HP:0010057)1.56510863
96Midface retrusion (HP:0011800)1.54859384
97Abnormality of the acetabulum (HP:0003170)1.54206838
98Entropion (HP:0000621)1.54092664
99Renovascular hypertension (HP:0100817)1.53972124
100Atrophic scars (HP:0001075)1.52036611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.79312195
2EEF2K4.15508141
3SMG14.02448610
4CDK123.93970370
5ICK3.55430842
6MAP3K102.67115976
7SIK12.51518286
8IRAK32.27277401
9MST1R2.20489824
10PRPF4B2.18873714
11TTN2.13238304
12EPHA22.09160566
13FGFR41.97777753
14SCYL21.85208825
15PDGFRA1.79552093
16CAMK1D1.69202961
17PKN21.59871498
18MTOR1.56312483
19NME21.55830345
20ERN11.47142824
21CAMK1G1.42440547
22RPS6KB21.40853411
23TTK1.37146239
24PAK41.37126688
25MET1.32763769
26RIPK11.27390135
27CDC71.26368437
28LATS21.22987054
29BRD41.22912217
30CDK71.19844815
31BUB11.09703042
32PTK21.08832931
33CDK41.05767997
34KSR21.04157391
35MAP3K81.02680257
36TSSK60.94984803
37CHEK10.86494534
38PTK60.86017079
39MAP3K130.84830223
40EIF2AK10.83828944
41CHEK20.82753994
42MAPK110.81375768
43MAP2K30.80385173
44CDK60.79754267
45LATS10.75542743
46LMTK20.75033278
47MAP3K90.74595852
48CDK80.74208819
49BMX0.71712061
50PASK0.70304195
51ATR0.69097416
52PAK20.67874514
53CDK90.66713656
54BRAF0.63181223
55SRPK10.61780511
56AURKB0.61536399
57MELK0.61456531
58MARK20.61202736
59NTRK10.60908475
60PRKD30.59793069
61PBK0.58662353
62NEK20.58359346
63CDC42BPA0.57259568
64FGFR30.57035795
65RAF10.56086683
66AURKA0.54338549
67CLK10.54132237
68STK40.54069641
69TYRO30.53390224
70AKT20.52822091
71CDK20.51829346
72RPS6KA20.51015841
73PRKD20.50706077
74NEK90.49535822
75CDK10.48648705
76RET0.48606722
77ARAF0.48356739
78TAOK20.48268580
79BRSK10.47350046
80NEK10.46973619
81PDPK10.44485986
82PDGFRB0.43687836
83RPS6KC10.42087027
84RPS6KL10.42087027
85ERBB40.40843237
86IRAK20.39728927
87TRPM70.38252754
88EPHB10.38153081
89MAP2K20.38120543
90ALK0.37684098
91MAP3K70.35319153
92PIM20.34731101
93MAP3K20.34595055
94LRRK20.33683736
95MAP3K60.33648574
96ATM0.32501582
97MAP3K10.32388647
98RPS6KB10.31907117
99WEE10.31338763
100TAF10.30375954

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.64386489
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32386924
3Chronic myeloid leukemia_Homo sapiens_hsa052202.18615727
4Central carbon metabolism in cancer_Homo sapiens_hsa052302.03822900
5Thyroid cancer_Homo sapiens_hsa052162.03691037
6Biosynthesis of amino acids_Homo sapiens_hsa012301.90630821
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87343786
8Cell cycle_Homo sapiens_hsa041101.83947487
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79386905
10Non-small cell lung cancer_Homo sapiens_hsa052231.75442021
11Pentose phosphate pathway_Homo sapiens_hsa000301.74826351
12Bladder cancer_Homo sapiens_hsa052191.70712436
13Lysine degradation_Homo sapiens_hsa003101.63246628
14Acute myeloid leukemia_Homo sapiens_hsa052211.60392451
15Small cell lung cancer_Homo sapiens_hsa052221.57996966
16Pancreatic cancer_Homo sapiens_hsa052121.53086013
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50939655
18Endometrial cancer_Homo sapiens_hsa052131.48064192
19mRNA surveillance pathway_Homo sapiens_hsa030151.47004629
20MicroRNAs in cancer_Homo sapiens_hsa052061.46229824
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43035855
22Adherens junction_Homo sapiens_hsa045201.40831705
23RNA transport_Homo sapiens_hsa030131.40229402
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38416179
25Base excision repair_Homo sapiens_hsa034101.33981727
26Prostate cancer_Homo sapiens_hsa052151.33790715
27Fructose and mannose metabolism_Homo sapiens_hsa000511.32998360
28Notch signaling pathway_Homo sapiens_hsa043301.32567233
29Spliceosome_Homo sapiens_hsa030401.31012722
30Other glycan degradation_Homo sapiens_hsa005111.24660288
31Non-homologous end-joining_Homo sapiens_hsa034501.22028886
32Viral carcinogenesis_Homo sapiens_hsa052031.21383495
33Glioma_Homo sapiens_hsa052141.20943120
34One carbon pool by folate_Homo sapiens_hsa006701.20014936
35Mismatch repair_Homo sapiens_hsa034301.19728669
36Carbon metabolism_Homo sapiens_hsa012001.18439274
37Insulin signaling pathway_Homo sapiens_hsa049101.17822732
38mTOR signaling pathway_Homo sapiens_hsa041501.17648472
39Proteoglycans in cancer_Homo sapiens_hsa052051.17042389
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15163390
41VEGF signaling pathway_Homo sapiens_hsa043701.14669789
42Renal cell carcinoma_Homo sapiens_hsa052111.12076293
43Focal adhesion_Homo sapiens_hsa045101.11394664
44Colorectal cancer_Homo sapiens_hsa052101.11036123
45ErbB signaling pathway_Homo sapiens_hsa040121.11031047
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08513695
47Nucleotide excision repair_Homo sapiens_hsa034201.07132648
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05520278
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04038525
50N-Glycan biosynthesis_Homo sapiens_hsa005101.02621657
51AMPK signaling pathway_Homo sapiens_hsa041521.01435477
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00172359
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98970951
54Galactose metabolism_Homo sapiens_hsa000520.98637010
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95444320
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.92080488
57ECM-receptor interaction_Homo sapiens_hsa045120.90649957
58Prion diseases_Homo sapiens_hsa050200.88833235
59Fatty acid biosynthesis_Homo sapiens_hsa000610.86256397
60HTLV-I infection_Homo sapiens_hsa051660.85206164
61Hepatitis B_Homo sapiens_hsa051610.84986833
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84875463
63Inositol phosphate metabolism_Homo sapiens_hsa005620.83698477
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.83035160
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82742424
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76233305
67Apoptosis_Homo sapiens_hsa042100.76218180
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75928163
69HIF-1 signaling pathway_Homo sapiens_hsa040660.74058532
70B cell receptor signaling pathway_Homo sapiens_hsa046620.72665076
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71006987
72Insulin resistance_Homo sapiens_hsa049310.70472788
73Prolactin signaling pathway_Homo sapiens_hsa049170.68305520
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67985320
75Hippo signaling pathway_Homo sapiens_hsa043900.67292471
76Choline metabolism in cancer_Homo sapiens_hsa052310.65567073
77Sulfur relay system_Homo sapiens_hsa041220.63580863
78Basal cell carcinoma_Homo sapiens_hsa052170.61922999
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61557238
80Hepatitis C_Homo sapiens_hsa051600.61337884
81Arginine biosynthesis_Homo sapiens_hsa002200.61131567
82Pathways in cancer_Homo sapiens_hsa052000.60816298
83Glucagon signaling pathway_Homo sapiens_hsa049220.60044016
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59850822
85Melanoma_Homo sapiens_hsa052180.58234444
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.57636767
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56931652
88Estrogen signaling pathway_Homo sapiens_hsa049150.56161236
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56072890
90p53 signaling pathway_Homo sapiens_hsa041150.56004856
91Systemic lupus erythematosus_Homo sapiens_hsa053220.53539502
92Alcoholism_Homo sapiens_hsa050340.53374970
93Pyrimidine metabolism_Homo sapiens_hsa002400.52537888
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52378396
95Epstein-Barr virus infection_Homo sapiens_hsa051690.52295669
96Tight junction_Homo sapiens_hsa045300.50733864
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49648636
98Amoebiasis_Homo sapiens_hsa051460.49114572
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48239034
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.48167885

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