ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	6.81386648
2	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	6.81386648
3	vascular smooth muscle contraction (GO:0014829)	6.49716693
4	pyrimidine nucleobase catabolic process (GO:0006208)	5.46982235
5	negative regulation of protein localization to cell surface (GO:2000009)	4.91167142
6	parental behavior (GO:0060746)	4.61131349
7	cullin deneddylation (GO:0010388)	4.44653976
8	positive regulation of mitochondrial membrane permeability (GO:0035794)	4.44571316
9	intraciliary transport (GO:0042073)	4.40929051
10	regulation of penile erection (GO:0060405)	4.40808370
11	nucleobase catabolic process (GO:0046113)	4.28345710
12	positive regulation of mitochondrial fission (GO:0090141)	4.24271998
13	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	4.15354649
14	maternal behavior (GO:0042711)	4.10628901
15	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.88112738
16	eye photoreceptor cell development (GO:0042462)	3.86180137
17	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.82870133
18	photoreceptor cell development (GO:0042461)	3.78797298
19	protein polyglutamylation (GO:0018095)	3.73286181
20	response to hyperoxia (GO:0055093)	3.71141878
21	response to increased oxygen levels (GO:0036296)	3.71141878
22	anterior/posterior axis specification, embryo (GO:0008595)	3.68077256
23	regulation of plasminogen activation (GO:0010755)	3.66060460
24	cAMP biosynthetic process (GO:0006171)	3.63888590
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.62190933
26	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.61321808
27	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.55796301
28	cellular response to sterol (GO:0036315)	3.53852154
29	cellular response to cholesterol (GO:0071397)	3.52029196
30	cilium morphogenesis (GO:0060271)	3.48281289
31	protein deneddylation (GO:0000338)	3.47096866
32	positive regulation of protein homodimerization activity (GO:0090073)	3.41598827
33	artery smooth muscle contraction (GO:0014824)	3.38836582
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.38311391
35	histone H2A acetylation (GO:0043968)	3.34938799
36	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.34447266
37	retina vasculature morphogenesis in camera-type eye (GO:0061299)	3.33290390
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.29037910
39	negative regulation of membrane potential (GO:0045837)	3.28776087
40	cerebral cortex radially oriented cell migration (GO:0021799)	3.26369942
41	forebrain morphogenesis (GO:0048853)	3.26156759
42	branched-chain amino acid catabolic process (GO:0009083)	3.23406537
43	cilium movement (GO:0003341)	3.19329715
44	cerebral cortex development (GO:0021987)	3.14543423
45	presynaptic membrane assembly (GO:0097105)	3.13768080
46	establishment of protein localization to Golgi (GO:0072600)	3.12167404
47	response to nitrosative stress (GO:0051409)	3.12109430
48	vasoconstriction (GO:0042310)	3.10126917
49	startle response (GO:0001964)	3.08808306
50	regulation of uterine smooth muscle contraction (GO:0070472)	3.05944220
51	response to lipoprotein particle (GO:0055094)	3.01877975
52	behavioral response to cocaine (GO:0048148)	3.01194585
53	centriole replication (GO:0007099)	2.99333684
54	negative regulation of neurotransmitter transport (GO:0051589)	2.96242704
55	positive regulation of respiratory burst (GO:0060267)	2.91938282
56	protein targeting to Golgi (GO:0000042)	2.90830451
57	interkinetic nuclear migration (GO:0022027)	2.90108244
58	phospholipid homeostasis (GO:0055091)	2.88662436
59	protein prenylation (GO:0018342)	2.87816912
60	prenylation (GO:0097354)	2.87816912
61	peptidyl-glutamic acid modification (GO:0018200)	2.87399114
62	response to auditory stimulus (GO:0010996)	2.87177923
63	ribosomal small subunit assembly (GO:0000028)	2.86605412
64	tonic smooth muscle contraction (GO:0014820)	2.83657103
65	acrosome assembly (GO:0001675)	2.81763312
66	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.81164405
67	dopamine transport (GO:0015872)	2.80480724
68	cellular response to antibiotic (GO:0071236)	2.80196062
69	cerebellar Purkinje cell layer development (GO:0021680)	2.79286051
70	serotonin receptor signaling pathway (GO:0007210)	2.78888339
71	positive regulation of developmental pigmentation (GO:0048087)	2.78869557
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.76721346
73	epithelial cilium movement (GO:0003351)	2.75532700
74	piRNA metabolic process (GO:0034587)	2.74944364
75	positive regulation of cAMP biosynthetic process (GO:0030819)	2.74889202
76	positive regulation of adenylate cyclase activity (GO:0045762)	2.73383057
77	single strand break repair (GO:0000012)	2.71714382
78	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.69578585
79	platelet dense granule organization (GO:0060155)	2.69135496
80	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.68374256
81	regulation of mitochondrial fission (GO:0090140)	2.66846546
82	L-serine metabolic process (GO:0006563)	2.64950837
83	cytoplasmic microtubule organization (GO:0031122)	2.64946695
84	synapsis (GO:0007129)	2.64362071
85	meiotic chromosome segregation (GO:0045132)	2.59615377
86	regulation of cilium movement (GO:0003352)	2.59457105
87	long-chain fatty acid biosynthetic process (GO:0042759)	2.59300998
88	mitochondrial DNA metabolic process (GO:0032042)	2.58458614
89	cilium assembly (GO:0042384)	2.57587684
90	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.57359233
91	regulation of neurotransmitter uptake (GO:0051580)	2.56752255
92	axoneme assembly (GO:0035082)	2.56558940
93	isoprenoid biosynthetic process (GO:0008299)	2.55259217
94	urinary tract smooth muscle contraction (GO:0014848)	2.54324237
95	cilium organization (GO:0044782)	2.51667599
96	regulation of protein kinase A signaling (GO:0010738)	2.50672467
97	synapse assembly (GO:0007416)	2.49597661
98	mitochondrial fission (GO:0000266)	2.49161865
99	corticosteroid receptor signaling pathway (GO:0031958)	2.46997163
100	retinal rod cell development (GO:0046548)	11.8531195

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.97845350
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.53491064
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.46659951
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.33431066
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.28478293
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.20884768
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92791614
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.85605540
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.76326442
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70466368
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.55529676
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.36959317
13	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.18547581
14	P300_19829295_ChIP-Seq_ESCs_Human	2.17500034
15	VDR_22108803_ChIP-Seq_LS180_Human	2.16334000
16	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.14447727
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06967021
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.02356243
19	FUS_26573619_Chip-Seq_HEK293_Human	1.99215582
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87829465
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86310277
22	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.84566868
23	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.83769565
24	EWS_26573619_Chip-Seq_HEK293_Human	1.78201111
25	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.75228201
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75067180
27	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73996549
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71269091
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63990447
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63507052
31	STAT3_23295773_ChIP-Seq_U87_Human	1.62310815
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62288771
33	TP53_16413492_ChIP-PET_HCT116_Human	1.61166726
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59427558
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.58408967
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.58408967
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57399482
38	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.55631538
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53883252
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52572861
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52135140
42	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.51169623
43	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.50333292
44	SOX9_26525672_Chip-Seq_HEART_Mouse	1.47967419
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46912734
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46286789
47	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.44988567
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.44610557
49	TP53_18474530_ChIP-ChIP_U2OS_Human	1.39318135
50	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.38779353
51	IGF1R_20145208_ChIP-Seq_DFB_Human	1.36937114
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36335281
53	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.35533349
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34296109
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32046611
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.32046611
57	TCF4_23295773_ChIP-Seq_U87_Human	1.31682239
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.30939566
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.30573519
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28884900
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28581908
62	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.28153685
63	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.27998461
64	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.27529513
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27097493
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26646960
67	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.26179240
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25821720
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.24801352
70	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.24748294
71	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.24748294
72	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.22208023
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.21023582
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20991048
75	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17491837
76	AR_25329375_ChIP-Seq_VCAP_Human	1.17367579
77	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.15069747
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14844396
79	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.13257200
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12446791
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11991691
82	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.09669321
83	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.09402087
84	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.09317190
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08610034
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07155475
87	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05321076
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03389186
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.02375674
90	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.02342108
91	BCAT_22108803_ChIP-Seq_LS180_Human	1.01239389
92	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.01100138
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00797464
94	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.00630029
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00322993
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00048381
97	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.99714086
98	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99364219
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.99271298
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98259058

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	5.21620878
2	MP0009379_abnormal_foot_pigmentation	4.32441597
3	MP0008877_abnormal_DNA_methylation	4.21468351
4	MP0004147_increased_porphyrin_level	4.09665518
5	MP0006292_abnormal_olfactory_placode	3.82045082
6	MP0005174_abnormal_tail_pigmentation	3.64305453
7	MP0001529_abnormal_vocalization	3.60498874
8	MP0003221_abnormal_cardiomyocyte_apopto	3.16252707
9	MP0000569_abnormal_digit_pigmentation	2.83783841
10	MP0005187_abnormal_penis_morphology	2.77735090
11	MP0003136_yellow_coat_color	2.73114532
12	MP0003787_abnormal_imprinting	2.54614299
13	MP0004270_analgesia	2.45821044
14	MP0005551_abnormal_eye_electrophysiolog	2.32122595
15	MP0003890_abnormal_embryonic-extraembry	2.30065310
16	MP0002638_abnormal_pupillary_reflex	2.24304139
17	MP0003121_genomic_imprinting	1.94966994
18	MP0004782_abnormal_surfactant_physiolog	1.93857543
19	MP0003191_abnormal_cellular_cholesterol	1.92691415
20	MP0002653_abnormal_ependyma_morphology	1.92314090
21	MP0008789_abnormal_olfactory_epithelium	1.78958726
22	MP0002234_abnormal_pharynx_morphology	1.65837612
23	MP0001486_abnormal_startle_reflex	1.59825640
24	MP0000647_abnormal_sebaceous_gland	1.59385843
25	MP0002095_abnormal_skin_pigmentation	1.57706827
26	MP0004859_abnormal_synaptic_plasticity	1.47636845
27	MP0001485_abnormal_pinna_reflex	1.43740255
28	MP0005394_taste/olfaction_phenotype	1.43540559
29	MP0005499_abnormal_olfactory_system	1.43540559
30	MP0002254_reproductive_system_inflammat	1.43194408
31	MP0008872_abnormal_physiological_respon	1.41531912
32	MP0000778_abnormal_nervous_system	1.36145729
33	MP0001984_abnormal_olfaction	1.34876694
34	MP0001293_anophthalmia	1.32038392
35	MP0006054_spinal_hemorrhage	1.29277881
36	MP0002876_abnormal_thyroid_physiology	1.28452300
37	MP0004885_abnormal_endolymph	1.23985370
38	MP0003119_abnormal_digestive_system	1.23449522
39	MP0001177_atelectasis	1.22899721
40	MP0002734_abnormal_mechanical_nocicepti	1.19699545
41	MP0004484_altered_response_of	1.18630310
42	MP0002736_abnormal_nociception_after	1.14348355
43	MP0001346_abnormal_lacrimal_gland	1.13173448
44	MP0003950_abnormal_plasma_membrane	1.12599121
45	MP0001299_abnormal_eye_distance/	1.10471523
46	MP0001853_heart_inflammation	1.09718921
47	MP0004019_abnormal_vitamin_homeostasis	1.08269776
48	MP0002233_abnormal_nose_morphology	1.05747456
49	MP0002102_abnormal_ear_morphology	1.05571067
50	MP0003567_abnormal_fetal_cardiomyocyte	1.04228037
51	MP0003937_abnormal_limbs/digits/tail_de	1.03333062
52	MP0004858_abnormal_nervous_system	1.01737994
53	MP0001286_abnormal_eye_development	1.01427381
54	MP0005253_abnormal_eye_physiology	0.95896813
55	MP0002295_abnormal_pulmonary_circulatio	0.95538245
56	MP0003122_maternal_imprinting	0.93205247
57	MP0002938_white_spotting	0.89312462
58	MP0002735_abnormal_chemical_nociception	0.88102665
59	MP0002163_abnormal_gland_morphology	0.86064309
60	MP0001764_abnormal_homeostasis	0.85222932
61	MP0002127_abnormal_cardiovascular_syste	0.85003109
62	MP0002572_abnormal_emotion/affect_behav	0.84763678
63	MP0000955_abnormal_spinal_cord	0.83575678
64	MP0005171_absent_coat_pigmentation	0.82955308
65	MP0005248_abnormal_Harderian_gland	0.79908576
66	MP0002733_abnormal_thermal_nociception	0.78318341
67	MP0002090_abnormal_vision	0.78199583
68	MP0001970_abnormal_pain_threshold	0.76221217
69	MP0003635_abnormal_synaptic_transmissio	0.73988340
70	MP0009840_abnormal_foam_cell	0.73413761
71	MP0003195_calcinosis	0.73033990
72	MP0005670_abnormal_white_adipose	0.72115734
73	MP0005386_behavior/neurological_phenoty	0.70491723
74	MP0004924_abnormal_behavior	0.70491723
75	MP0003646_muscle_fatigue	0.69973422
76	MP0005379_endocrine/exocrine_gland_phen	0.69223095
77	MP0001661_extended_life_span	0.67931930
78	MP0003880_abnormal_central_pattern	0.67630228
79	MP0000631_abnormal_neuroendocrine_gland	0.67400046
80	MP0000749_muscle_degeneration	0.66948430
81	MP0005195_abnormal_posterior_eye	0.66869926
82	MP0005647_abnormal_sex_gland	0.65589068
83	MP0003718_maternal_effect	0.63373383
84	MP0000026_abnormal_inner_ear	0.61831224
85	MP0000516_abnormal_urinary_system	0.61426777
86	MP0005367_renal/urinary_system_phenotyp	0.61426777
87	MP0008875_abnormal_xenobiotic_pharmacok	0.57954517
88	MP0005075_abnormal_melanosome_morpholog	0.57824694
89	MP0005360_urolithiasis	0.57763505
90	MP0002697_abnormal_eye_size	0.56902420
91	MP0002063_abnormal_learning/memory/cond	0.55965032
92	MP0002752_abnormal_somatic_nervous	0.55516337
93	MP0005310_abnormal_salivary_gland	0.55194849
94	MP0001963_abnormal_hearing_physiology	0.55058929
95	MP0005391_vision/eye_phenotype	0.54374458
96	MP0009745_abnormal_behavioral_response	0.54298188
97	MP0010678_abnormal_skin_adnexa	0.54016449
98	MP0009046_muscle_twitch	0.53807230
99	MP0008260_abnormal_autophagy	0.53284026
100	MP0000013_abnormal_adipose_tissue	0.52741652

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chorioretinal atrophy (HP:0000533)	7.16349474
2	Reticulocytopenia (HP:0001896)	5.69918438
3	Abolished electroretinogram (ERG) (HP:0000550)	4.28371409
4	Colon cancer (HP:0003003)	4.05859312
5	Polyphagia (HP:0002591)	3.56890377
6	Abnormality of the metopic suture (HP:0005556)	3.55373141
7	Partial duplication of thumb phalanx (HP:0009944)	3.55137514
8	Concave nail (HP:0001598)	3.41259182
9	Volvulus (HP:0002580)	3.21229201
10	Tubulointerstitial nephritis (HP:0001970)	3.11062531
11	Abnormal ciliary motility (HP:0012262)	3.08990547
12	Partial duplication of the phalanx of hand (HP:0009999)	2.98699214
13	Prominent metopic ridge (HP:0005487)	2.96739252
14	Abnormal respiratory motile cilium physiology (HP:0012261)	2.93930745
15	Intestinal atresia (HP:0011100)	2.85867776
16	Abnormality of chromosome stability (HP:0003220)	2.84343242
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.84151798
18	Duplication of thumb phalanx (HP:0009942)	2.82760343
19	Diaphragmatic weakness (HP:0009113)	2.72707409
20	Abnormality of DNA repair (HP:0003254)	2.68754528
21	Febrile seizures (HP:0002373)	2.59629161
22	Postaxial foot polydactyly (HP:0001830)	2.59394984
23	Pancreatic fibrosis (HP:0100732)	2.55195790
24	Rhinitis (HP:0012384)	2.55086131
25	Molar tooth sign on MRI (HP:0002419)	2.55066945
26	Abnormality of midbrain morphology (HP:0002418)	2.55066945
27	Limb hypertonia (HP:0002509)	2.40601163
28	Chronic hepatic failure (HP:0100626)	2.40027970
29	Postnatal microcephaly (HP:0005484)	2.38382265
30	Abnormality of glycine metabolism (HP:0010895)	2.35948403
31	Abnormality of serine family amino acid metabolism (HP:0010894)	2.35948403
32	Renal dysplasia (HP:0000110)	2.33365564
33	Abnormal eating behavior (HP:0100738)	2.32029060
34	Methylmalonic aciduria (HP:0012120)	2.31763014
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.31139824
36	Papillary thyroid carcinoma (HP:0002895)	2.27946257
37	Long clavicles (HP:0000890)	2.26955704
38	Nephronophthisis (HP:0000090)	2.26906439
39	Pancreatic cysts (HP:0001737)	2.24689999
40	Hepatoblastoma (HP:0002884)	2.21379091
41	Hypoplastic pelvis (HP:0008839)	2.19618265
42	11 pairs of ribs (HP:0000878)	2.19148425
43	True hermaphroditism (HP:0010459)	2.18776521
44	Hyperglycinuria (HP:0003108)	2.18723210
45	Abnormality of the intrinsic pathway (HP:0010989)	2.16149651
46	Renal Fanconi syndrome (HP:0001994)	2.13195204
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12786330
48	Severe muscular hypotonia (HP:0006829)	2.12711855
49	Progressive cerebellar ataxia (HP:0002073)	2.11078214
50	Abnormality of the renal medulla (HP:0100957)	2.09430108
51	Short tibia (HP:0005736)	2.08743749
52	Occipital encephalocele (HP:0002085)	2.07443675
53	Abnormality of the labia minora (HP:0012880)	2.07012944
54	Septo-optic dysplasia (HP:0100842)	2.05003259
55	Postaxial hand polydactyly (HP:0001162)	2.01436105
56	Prolonged partial thromboplastin time (HP:0003645)	1.99622367
57	Abnormal respiratory motile cilium morphology (HP:0005938)	1.99351248
58	Abnormal respiratory epithelium morphology (HP:0012253)	1.99351248
59	Focal motor seizures (HP:0011153)	1.98891821
60	Atonic seizures (HP:0010819)	1.98170053
61	Facial hemangioma (HP:0000329)	1.96097636
62	Decreased muscle mass (HP:0003199)	1.96035745
63	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.90702289
64	Asplenia (HP:0001746)	1.86475354
65	Albinism (HP:0001022)	1.86014260
66	3-Methylglutaconic aciduria (HP:0003535)	1.85209948
67	Gastrointestinal atresia (HP:0002589)	1.83799587
68	Hyperglycinemia (HP:0002154)	1.83451072
69	Preaxial foot polydactyly (HP:0001841)	1.82075523
70	Decreased lacrimation (HP:0000633)	1.82065585
71	Hypoplastic labia majora (HP:0000059)	1.80411754
72	Thyroid carcinoma (HP:0002890)	1.79365292
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78489311
74	Tubular atrophy (HP:0000092)	1.74673335
75	Autoimmune thrombocytopenia (HP:0001973)	1.73422263
76	Small hand (HP:0200055)	1.73000822
77	Short chin (HP:0000331)	1.72760233
78	Median cleft lip (HP:0000161)	1.72419986
79	Abnormality of the ischium (HP:0003174)	1.71971893
80	Abnormality of the antihelix (HP:0009738)	1.71882309
81	Absent thumb (HP:0009777)	1.70808227
82	Male infertility (HP:0003251)	1.69706849
83	Acute encephalopathy (HP:0006846)	1.69040440
84	Poor head control (HP:0002421)	1.66345884
85	Triphalangeal thumb (HP:0001199)	1.65610259
86	Congenital hepatic fibrosis (HP:0002612)	1.64353103
87	IgM deficiency (HP:0002850)	1.62609983
88	Renal hypoplasia (HP:0000089)	1.60130146
89	Chorioretinal coloboma (HP:0000567)	1.58863595
90	Abnormality of the labia majora (HP:0012881)	1.58413115
91	Curly hair (HP:0002212)	1.57056712
92	Absent speech (HP:0001344)	1.56810051
93	Vertebral hypoplasia (HP:0008417)	1.55675918
94	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.55675918
95	Myelomeningocele (HP:0002475)	1.54650906
96	Prominent nasal bridge (HP:0000426)	1.53248728
97	Tubulointerstitial abnormality (HP:0001969)	1.52316072
98	Acute necrotizing encephalopathy (HP:0006965)	1.51659620
99	Abnormality of the ileum (HP:0001549)	1.51315247
100	Epileptic encephalopathy (HP:0200134)	1.50801147

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.73882806
2	TNIK	3.58742264
3	CASK	3.50863451
4	BMPR1B	2.77583711
5	MAP3K2	2.67426802
6	BCR	2.40273485
7	MAP4K2	2.20098943
8	WNK3	2.17716970
9	PINK1	2.15995539
10	NTRK2	2.07985061
11	PKN2	2.02057029
12	NEK2	1.94962913
13	STK39	1.94769686
14	MUSK	1.82831863
15	CSNK1G1	1.72167532
16	MKNK2	1.68762394
17	AKT3	1.59352167
18	CCNB1	1.58110368
19	STK3	1.56168712
20	KSR2	1.45808039
21	MAP3K4	1.45011517
22	MAPKAPK3	1.42773211
23	KSR1	1.39244052
24	CAMK1D	1.37270298
25	OXSR1	1.34125891
26	MAP3K10	1.31010847
27	BRD4	1.30471685
28	ERBB3	1.28547058
29	MET	1.26366696
30	RAF1	1.21730928
31	NTRK3	1.21579160
32	MAPK15	1.17841602
33	TEC	1.16529185
34	ARAF	1.15759280
35	CAMK1G	1.15661164
36	PAK6	1.14763173
37	TGFBR1	1.11200346
38	FGFR2	1.08873477
39	CDK8	1.08354982
40	TIE1	1.06907798
41	MAP2K7	1.06781706
42	CSNK1G2	1.06479590
43	BRAF	1.03966112
44	MINK1	1.03290408
45	PTK2	0.96834547
46	CSNK1A1L	0.95839903
47	NEK6	0.91391859
48	MKNK1	0.91356113
49	WNK4	0.91079537
50	PTK2B	0.90019132
51	MAPK13	0.88043561
52	FGR	0.87081869
53	CAMK1	0.86336190
54	FLT3	0.85444889
55	MAP3K9	0.83602324
56	MOS	0.80897672
57	CSNK1G3	0.78190795
58	PRKD3	0.78166154
59	ROCK1	0.77846899
60	ROCK2	0.75174412
61	NEK1	0.71508690
62	PLK3	0.70126353
63	MARK1	0.68860100
64	NUAK1	0.66713291
65	NLK	0.63406568
66	EPHB2	0.62660905
67	CSNK1A1	0.58945190
68	IRAK1	0.58632461
69	BUB1	0.55866449
70	FGFR1	0.55155501
71	SRPK1	0.55010260
72	DDR2	0.53391994
73	PLK4	0.52971714
74	PRKCE	0.52587347
75	PIK3CG	0.50375756
76	MAP3K6	0.50061136
77	TRIM28	0.49406953
78	PRKACB	0.47472446
79	RET	0.47347042
80	CDK9	0.47335391
81	INSR	0.46737178
82	EIF2AK2	0.46703864
83	EGFR	0.45908686
84	SGK2	0.45148169
85	YES1	0.44851854
86	CAMK2A	0.43682354
87	PAK2	0.43258608
88	EIF2AK3	0.43200504
89	TSSK6	0.43136389
90	TGFBR2	0.42652213
91	ABL1	0.42605487
92	PAK3	0.40927916
93	INSRR	0.39413447
94	BCKDK	0.39101450
95	PASK	0.39001971
96	NEK9	0.37765010
97	PIK3CA	0.37731220
98	FES	0.35709972
99	PLK2	0.35634227
100	MAP3K12	0.34492117

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.55581659
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.90398487
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.68718133
4	Steroid biosynthesis_Homo sapiens_hsa00100	3.06381505
5	Protein export_Homo sapiens_hsa03060	3.02676348
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.68259995
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.54768283
8	Butanoate metabolism_Homo sapiens_hsa00650	2.19396222
9	Propanoate metabolism_Homo sapiens_hsa00640	2.18912877
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.13239290
11	Taste transduction_Homo sapiens_hsa04742	2.11065384
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.94003110
13	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.88770872
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.77279954
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72071880
16	RNA degradation_Homo sapiens_hsa03018	1.64642363
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62139706
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58359405
19	Nicotine addiction_Homo sapiens_hsa05033	1.57821287
20	p53 signaling pathway_Homo sapiens_hsa04115	1.41426194
21	RNA polymerase_Homo sapiens_hsa03020	1.39289841
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.38601918
23	Homologous recombination_Homo sapiens_hsa03440	1.37844081
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33155351
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21243297
26	Basal transcription factors_Homo sapiens_hsa03022	1.18566167
27	Phototransduction_Homo sapiens_hsa04744	1.16231198
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.13753648
29	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.12410171
30	GABAergic synapse_Homo sapiens_hsa04727	1.08839593
31	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.07063236
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05186654
33	Sulfur relay system_Homo sapiens_hsa04122	1.04078919
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96812802
35	Folate biosynthesis_Homo sapiens_hsa00790	0.96080539
36	Serotonergic synapse_Homo sapiens_hsa04726	0.95814328
37	Morphine addiction_Homo sapiens_hsa05032	0.95273234
38	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92940152
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87010924
40	Huntingtons disease_Homo sapiens_hsa05016	0.85927441
41	Arginine biosynthesis_Homo sapiens_hsa00220	0.84924745
42	Fatty acid elongation_Homo sapiens_hsa00062	0.82856084
43	Amphetamine addiction_Homo sapiens_hsa05031	0.81709438
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.81251225
45	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79809741
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.78680261
47	ABC transporters_Homo sapiens_hsa02010	0.77204953
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.75157372
49	Sulfur metabolism_Homo sapiens_hsa00920	0.70038677
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.68933686
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.68635250
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67436490
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67353532
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.63345785
55	African trypanosomiasis_Homo sapiens_hsa05143	0.62972141
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62625929
57	Regulation of autophagy_Homo sapiens_hsa04140	0.61186252
58	Proteasome_Homo sapiens_hsa03050	0.60976801
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.60569488
60	Circadian entrainment_Homo sapiens_hsa04713	0.60282365
61	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60212911
62	Alzheimers disease_Homo sapiens_hsa05010	0.58292764
63	Axon guidance_Homo sapiens_hsa04360	0.54041443
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.52922546
65	Colorectal cancer_Homo sapiens_hsa05210	0.52628293
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.50411588
67	Complement and coagulation cascades_Homo sapiens_hsa04610	0.50251353
68	Cocaine addiction_Homo sapiens_hsa05030	0.49618773
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.47880563
70	Gap junction_Homo sapiens_hsa04540	0.47726857
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47359002
72	Legionellosis_Homo sapiens_hsa05134	0.47078388
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.46092091
74	Oocyte meiosis_Homo sapiens_hsa04114	0.45414319
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43793493
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43757829
77	Melanogenesis_Homo sapiens_hsa04916	0.43496346
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43282149
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41945378
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41576076
81	Prion diseases_Homo sapiens_hsa05020	0.41472699
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41370744
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40676458
84	Circadian rhythm_Homo sapiens_hsa04710	0.39456232
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38747387
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.37622907
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36975676
88	Alcoholism_Homo sapiens_hsa05034	0.36672075
89	Olfactory transduction_Homo sapiens_hsa04740	0.36049914
90	Adherens junction_Homo sapiens_hsa04520	0.34615670
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34077685
92	One carbon pool by folate_Homo sapiens_hsa00670	0.32970344
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32704897
94	Ribosome_Homo sapiens_hsa03010	0.32243423
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.31896661
96	Purine metabolism_Homo sapiens_hsa00230	0.31428621
97	Salivary secretion_Homo sapiens_hsa04970	0.30646181
98	Cholinergic synapse_Homo sapiens_hsa04725	0.29779264
99	Peroxisome_Homo sapiens_hsa04146	0.29310722
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.29054963

GCNT1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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