GCNT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)6.36432383
2intestinal absorption (GO:0050892)6.02389116
3intestinal cholesterol absorption (GO:0030299)4.91211092
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.85968563
5endocrine pancreas development (GO:0031018)4.58333452
6reverse cholesterol transport (GO:0043691)4.50538966
7regulation of type B pancreatic cell apoptotic process (GO:2000674)4.45311805
8high-density lipoprotein particle remodeling (GO:0034375)4.37040727
9positive regulation of glycoprotein biosynthetic process (GO:0010560)4.24851340
10regulation of glucokinase activity (GO:0033131)4.07625994
11regulation of hexokinase activity (GO:1903299)4.07625994
12purine ribonucleotide transport (GO:0015868)4.00541268
13adenine nucleotide transport (GO:0051503)3.99056510
14lactate metabolic process (GO:0006089)3.97497343
15negative regulation of hormone biosynthetic process (GO:0032353)3.85582636
16protein-lipid complex remodeling (GO:0034368)3.81447877
17macromolecular complex remodeling (GO:0034367)3.81447877
18plasma lipoprotein particle remodeling (GO:0034369)3.81447877
19purine nucleotide transport (GO:0015865)3.81254898
20regulation of bile acid biosynthetic process (GO:0070857)3.80552005
21positive regulation of glycolytic process (GO:0045821)3.79626289
22urea metabolic process (GO:0019627)3.78750679
23urea cycle (GO:0000050)3.78750679
24negative regulation of acute inflammatory response (GO:0002674)3.78527474
25lipoprotein metabolic process (GO:0042157)3.78267333
26insulin secretion (GO:0030073)3.78003034
27negative regulation of protein oligomerization (GO:0032460)3.76054441
28regulation of protein glycosylation (GO:0060049)3.74451281
29regulation of tight junction assembly (GO:2000810)3.72975959
30cellular ketone body metabolic process (GO:0046950)3.72592023
31homocysteine metabolic process (GO:0050667)3.67676429
32cytochrome complex assembly (GO:0017004)3.66111224
33protein-lipid complex assembly (GO:0065005)3.65917397
34vitamin biosynthetic process (GO:0009110)3.65701160
35very-low-density lipoprotein particle assembly (GO:0034379)3.65504472
36drug catabolic process (GO:0042737)3.64924486
37regulation of female gonad development (GO:2000194)3.60222737
38plasma lipoprotein particle assembly (GO:0034377)3.59667330
39cholesterol efflux (GO:0033344)3.58174143
40respiratory chain complex IV assembly (GO:0008535)3.57528755
41phospholipid efflux (GO:0033700)3.52607303
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.50927286
43negative regulation of glycogen metabolic process (GO:0070874)3.49542248
44cysteine metabolic process (GO:0006534)3.48115647
45inositol phosphate catabolic process (GO:0071545)3.45731420
46peptide hormone processing (GO:0016486)3.44920826
47signal peptide processing (GO:0006465)3.42763435
48positive regulation of protein autophosphorylation (GO:0031954)3.41710070
49nitric oxide mediated signal transduction (GO:0007263)3.41704794
50flavonoid metabolic process (GO:0009812)3.41258033
51sulfur amino acid catabolic process (GO:0000098)3.41127789
52negative regulation of hormone metabolic process (GO:0032351)3.40659908
53epoxygenase P450 pathway (GO:0019373)3.38567359
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.38014277
55ovulation cycle (GO:0042698)3.37849538
56alpha-linolenic acid metabolic process (GO:0036109)3.35482578
57DNA deamination (GO:0045006)3.34976751
58positive regulation of respiratory burst (GO:0060267)3.32626773
59hormone catabolic process (GO:0042447)3.31727089
60protein-lipid complex subunit organization (GO:0071825)3.29064234
61negative regulation of membrane potential (GO:0045837)3.28911106
62inositol phosphate dephosphorylation (GO:0046855)3.26623781
63phosphorylated carbohydrate dephosphorylation (GO:0046838)3.26623781
64amino-acid betaine metabolic process (GO:0006577)3.26139130
65ketone body metabolic process (GO:1902224)3.25554616
66positive regulation of glycoprotein metabolic process (GO:1903020)3.24887561
67carnitine metabolic process (GO:0009437)3.23319914
68plasma lipoprotein particle organization (GO:0071827)3.23074324
69nitrogen cycle metabolic process (GO:0071941)3.22435557
70magnesium ion transport (GO:0015693)3.21952501
71regulation of cholesterol esterification (GO:0010872)3.18262376
72negative regulation of fibrinolysis (GO:0051918)3.16558796
73glandular epithelial cell differentiation (GO:0002067)3.12077404
74response to pheromone (GO:0019236)3.12019981
75regulation of triglyceride catabolic process (GO:0010896)3.11213021
76L-fucose catabolic process (GO:0042355)3.10607214
77fucose catabolic process (GO:0019317)3.10607214
78L-fucose metabolic process (GO:0042354)3.10607214
79chondrocyte proliferation (GO:0035988)3.10124625
80keratinocyte development (GO:0003334)3.08256547
81protein complex biogenesis (GO:0070271)3.08057392
82angiotensin maturation (GO:0002003)3.06802658
83prenylation (GO:0097354)3.06162847
84protein prenylation (GO:0018342)3.06162847
853-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.04456045
86purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.04456045
87cellular modified amino acid catabolic process (GO:0042219)3.02878803
88regulation of cholesterol homeostasis (GO:2000188)3.02834030
89zinc ion homeostasis (GO:0055069)3.02370769
90notochord development (GO:0030903)2.97935229
91zinc ion transmembrane transport (GO:0071577)2.97356973
92phospholipid homeostasis (GO:0055091)2.96708801
93positive regulation of peptide hormone secretion (GO:0090277)2.89280935
94regulation of fatty acid beta-oxidation (GO:0031998)2.88307440
95sterol homeostasis (GO:0055092)2.88194843
96negative regulation of protein activation cascade (GO:2000258)2.87310694
97cholesterol homeostasis (GO:0042632)2.86366528
98urate metabolic process (GO:0046415)2.86211129
99cholesterol transport (GO:0030301)2.85839203
100sterol transport (GO:0015918)2.85839203
101regulation of neurotransmitter uptake (GO:0051580)2.85614906
102dentate gyrus development (GO:0021542)2.85123889
103gap junction assembly (GO:0016264)2.84110711
104retinal metabolic process (GO:0042574)2.83331944
105positive regulation of triglyceride metabolic process (GO:0090208)2.83024095
106positive regulation of actin filament depolymerization (GO:0030836)2.82629113
107positive regulation of insulin secretion (GO:0032024)2.80943954
108polyol catabolic process (GO:0046174)2.78688210
109alanine transport (GO:0032328)2.78049817
110bile acid and bile salt transport (GO:0015721)2.77038605
111cellular biogenic amine catabolic process (GO:0042402)2.76205676
112amine catabolic process (GO:0009310)2.76205676
113positive regulation of peptide secretion (GO:0002793)2.75691521
114regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.74071066
115negative regulation of complement activation (GO:0045916)2.72345566
116sulfation (GO:0051923)2.72170552
117xenobiotic catabolic process (GO:0042178)2.72086898
118positive regulation of fatty acid biosynthetic process (GO:0045723)2.70030338
119prostate gland growth (GO:0060736)2.70023178
120heme transport (GO:0015886)2.68910085
121cell adhesion mediated by integrin (GO:0033627)2.68627096
122glycerophospholipid catabolic process (GO:0046475)2.67639023
123signal transduction involved in regulation of gene expression (GO:0023019)2.67627730
124mesenchymal-epithelial cell signaling (GO:0060638)2.66996362
125regulation of acrosome reaction (GO:0060046)2.66818453
126negative regulation of sodium ion transport (GO:0010766)2.66204849
127negative regulation of lipid transport (GO:0032369)2.63977248
128negative regulation of neurological system process (GO:0031645)2.63471931
129digestive system process (GO:0022600)2.61171504
130regulation of fibrinolysis (GO:0051917)2.60645348
131platelet dense granule organization (GO:0060155)2.60327020
132cobalamin metabolic process (GO:0009235)2.59947150
133positive regulation of lipid catabolic process (GO:0050996)2.59572943
134mitochondrial respiratory chain complex assembly (GO:0033108)2.59518575
135positive regulation of meiosis (GO:0045836)2.58775575
136regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.58656305
137positive regulation of fatty acid beta-oxidation (GO:0032000)2.57352286
138negative regulation of cholesterol transport (GO:0032375)2.56987209
139negative regulation of sterol transport (GO:0032372)2.56987209
140parental behavior (GO:0060746)2.56688067
141one-carbon metabolic process (GO:0006730)2.55996349
142negative regulation of activin receptor signaling pathway (GO:0032926)2.55991156
143zinc ion transport (GO:0006829)2.55845019
144energy homeostasis (GO:0097009)2.55784080
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.55110610
146inositol phosphate-mediated signaling (GO:0048016)2.53564857
147regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53535448
148triglyceride homeostasis (GO:0070328)2.52579795
149acylglycerol homeostasis (GO:0055090)2.52579795
150regulation of plasminogen activation (GO:0010755)2.52366878
151axoneme assembly (GO:0035082)2.51775469
152regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.51676796
153regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.51676796
154peptide secretion (GO:0002790)2.51514412
155negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50268482
156female gamete generation (GO:0007292)2.49941565
157cellular zinc ion homeostasis (GO:0006882)2.49505816
158nucleoside transport (GO:0015858)2.49345937
159dicarboxylic acid biosynthetic process (GO:0043650)2.49063197
160membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.48880236
161peptide hormone secretion (GO:0030072)2.47368843
162establishment of protein localization to Golgi (GO:0072600)2.47359366
163protein targeting to Golgi (GO:0000042)2.45948297
164regulation of protein autophosphorylation (GO:0031952)2.45731774
165positive regulation of meiotic cell cycle (GO:0051446)2.44164710
166regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.44041259
167negative regulation of protein autophosphorylation (GO:0031953)2.43975360
168citrulline biosynthetic process (GO:0019240)2.43890769
169transcytosis (GO:0045056)2.43453665
170negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.43360258
171negative regulation of execution phase of apoptosis (GO:1900118)2.42921853
172regulation of lipoprotein metabolic process (GO:0050746)2.42507629
173positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.41684462
174regulation of energy homeostasis (GO:2000505)2.40791757
175low-density lipoprotein particle remodeling (GO:0034374)2.40363170
176cartilage morphogenesis (GO:0060536)2.40256715
177negative regulation of fatty acid transport (GO:2000192)2.39830124
178piRNA metabolic process (GO:0034587)2.39497600
179negative regulation of gluconeogenesis (GO:0045721)2.38716460
180negative regulation of circadian rhythm (GO:0042754)2.38680647
181negative regulation of steroid metabolic process (GO:0045939)2.38147632
182epithelial cell fate commitment (GO:0072148)2.38004650
183proline transport (GO:0015824)2.37867478
184sulfate transmembrane transport (GO:1902358)2.37179143
185regulation of insulin secretion (GO:0050796)2.37169558
186peptide transport (GO:0015833)2.36869530
187kynurenine metabolic process (GO:0070189)2.36279342
188positive regulation of lipoprotein lipase activity (GO:0051006)2.36221922
189positive regulation of triglyceride lipase activity (GO:0061365)2.36221922
190S-adenosylmethionine metabolic process (GO:0046500)2.36023957
191regulation of glomerulus development (GO:0090192)2.35781185
192positive regulation of macroautophagy (GO:0016239)2.35277555
193regulation of mesoderm development (GO:2000380)2.35233217
194protein K6-linked ubiquitination (GO:0085020)2.35167562
195positive regulation of response to extracellular stimulus (GO:0032106)2.35021295
196positive regulation of response to nutrient levels (GO:0032109)2.35021295
197cellular glucuronidation (GO:0052695)2.34697979
198midgut development (GO:0007494)2.34303290
199positive regulation of fatty acid oxidation (GO:0046321)2.34255615
200lipid homeostasis (GO:0055088)2.33142344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.90759418
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.52990894
3ZNF274_21170338_ChIP-Seq_K562_Hela2.83441407
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.71845395
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.62291552
6VDR_22108803_ChIP-Seq_LS180_Human2.60475050
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.59928120
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50595923
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.13421892
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08902013
11EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99205305
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.97140633
13TP53_16413492_ChIP-PET_HCT116_Human1.95742354
14FUS_26573619_Chip-Seq_HEK293_Human1.92407234
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90305521
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90277036
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89591681
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80291115
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79783287
20EWS_26573619_Chip-Seq_HEK293_Human1.76179732
21GBX2_23144817_ChIP-Seq_PC3_Human1.74062975
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72117930
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70758004
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.69204671
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69179164
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68408614
27TAF15_26573619_Chip-Seq_HEK293_Human1.59813888
28ER_23166858_ChIP-Seq_MCF-7_Human1.59807050
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59629076
30CJUN_26792858_Chip-Seq_BT549_Human1.57500366
31RXR_22108803_ChIP-Seq_LS180_Human1.57102222
32* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54953864
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52218351
34IGF1R_20145208_ChIP-Seq_DFB_Human1.49773690
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.49452212
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48783642
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.47202214
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.46444792
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46219883
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45051494
41AR_21572438_ChIP-Seq_LNCaP_Human1.44014835
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42291990
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41976180
44P53_22387025_ChIP-Seq_ESCs_Mouse1.41853515
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41624315
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.41404982
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40081757
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.40081757
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39999076
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38942457
51SOX2_19829295_ChIP-Seq_ESCs_Human1.38649749
52NANOG_19829295_ChIP-Seq_ESCs_Human1.38649749
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38448425
54CBP_20019798_ChIP-Seq_JUKART_Human1.38448425
55BCAT_22108803_ChIP-Seq_LS180_Human1.37661237
56CLOCK_20551151_ChIP-Seq_293T_Human1.36942773
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36436119
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36436119
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35840144
60TCF4_22108803_ChIP-Seq_LS180_Human1.35199848
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35123094
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34327267
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33981596
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32831001
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32830458
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.32636545
67HTT_18923047_ChIP-ChIP_STHdh_Human1.32443435
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31784030
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.31696100
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31650966
71* TP63_23658742_ChIP-Seq_EP156T_Human1.31628417
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31448063
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.31184678
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.31177792
75SOX2_20726797_ChIP-Seq_SW620_Human1.28848874
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27721724
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.26973992
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.26535710
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.25557926
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25521636
81* TCF4_23295773_ChIP-Seq_U87_Human1.25459365
82TP53_22573176_ChIP-Seq_HFKS_Human1.25437490
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24440481
84* GATA4_25053715_ChIP-Seq_YYC3_Human1.22997046
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22923812
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22497551
87TP53_18474530_ChIP-ChIP_U2OS_Human1.22199247
88AR_21909140_ChIP-Seq_LNCAP_Human1.20972528
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20179070
90P300_18555785_Chip-Seq_ESCs_Mouse1.19714830
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.19674934
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.19209086
93* STAT3_23295773_ChIP-Seq_U87_Human1.19168604
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.19069230
95SMAD4_21799915_ChIP-Seq_A2780_Human1.18615734
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.17642692
97CDX2_22108803_ChIP-Seq_LS180_Human1.17234835
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16180668
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15705784
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.15272331
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14862047
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14346755
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13913867
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13823252
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13381547
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13238167
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.12789704
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.12679137
109AR_20517297_ChIP-Seq_VCAP_Human1.12518608
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12138470
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12034104
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11602979
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11424218
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11263048
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11192359
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10309148
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10238288
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10166930
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09887601
120BRD4_25478319_ChIP-Seq_HGPS_Human1.09535984
121NCOR_22424771_ChIP-Seq_293T_Human1.09352864
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.08978492
123* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08383112
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08073008
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.08035471
126AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07657443
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07214070
128OCT4_18555785_Chip-Seq_ESCs_Mouse1.05959636
129RUNX2_22187159_ChIP-Seq_PCA_Human1.04605753
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03112038
131SOX2_21211035_ChIP-Seq_LN229_Gbm1.02034410
132PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01461951
133GABP_17652178_ChIP-ChIP_JURKAT_Human1.01100302
134PHF8_20622853_ChIP-Seq_HELA_Human1.00884242
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00632695
136CTCF_18555785_Chip-Seq_ESCs_Mouse0.99727901
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99653229
138MYC_18940864_ChIP-ChIP_HL60_Human0.99374250
139IRF8_22096565_ChIP-ChIP_GC-B_Human0.99084670
140HNF4A_19822575_ChIP-Seq_HepG2_Human0.99078113
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98297996
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.98293499
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.97809527
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97676181
145AR_19668381_ChIP-Seq_PC3_Human0.96189271
146AR_25329375_ChIP-Seq_VCAP_Human0.95879252
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95471773
148* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95112821
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.93247583
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93059943
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92684669
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91564143
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90315430
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90267015
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90200678
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89766647
157P300_19829295_ChIP-Seq_ESCs_Human0.89698672
158KLF5_25053715_ChIP-Seq_YYC3_Human0.89410172
159JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89289178
160* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88613239
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88594462
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88328396
163KDM2B_26808549_Chip-Seq_REH_Human0.86572911
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.86423797
165FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86357577
166NANOG_18555785_Chip-Seq_ESCs_Mouse0.86187582
167SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85885116
168RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85252150
169ISL1_27105846_Chip-Seq_CPCs_Mouse0.84175993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.54162777
2MP0002837_dystrophic_cardiac_calcinosis4.60925436
3MP0003705_abnormal_hypodermis_morpholog4.57929055
4MP0009384_cardiac_valve_regurgitation4.42949961
5MP0002139_abnormal_hepatobiliary_system3.99206547
6MP0002163_abnormal_gland_morphology3.29540297
7MP0003787_abnormal_imprinting3.27716869
8MP0005379_endocrine/exocrine_gland_phen3.19410922
9MP0005085_abnormal_gallbladder_physiolo3.19352929
10MP0005377_hearing/vestibular/ear_phenot3.10247916
11MP0003878_abnormal_ear_physiology3.10247916
12MP0003252_abnormal_bile_duct3.07228043
13MP0005365_abnormal_bile_salt3.03066549
14MP0002254_reproductive_system_inflammat2.90026788
15MP0003283_abnormal_digestive_organ2.88419114
16MP0001666_abnormal_nutrient_absorption2.77537812
17MP0003718_maternal_effect2.72394609
18MP0005451_abnormal_body_composition2.64052079
19MP0008877_abnormal_DNA_methylation2.58383235
20MP0008875_abnormal_xenobiotic_pharmacok2.36542243
21MP0000566_synostosis2.36306082
22MP0004264_abnormal_extraembryonic_tissu2.35740059
23MP0009840_abnormal_foam_cell2.31076085
24MP0010329_abnormal_lipoprotein_level2.30184662
25MP0009697_abnormal_copulation2.29502499
26MP0005670_abnormal_white_adipose2.14181675
27MP0002693_abnormal_pancreas_physiology2.08665183
28MP0000516_abnormal_urinary_system2.00513815
29MP0005367_renal/urinary_system_phenotyp2.00513815
30MP0005646_abnormal_pituitary_gland1.98580842
31MP0006072_abnormal_retinal_apoptosis1.98243305
32MP0003122_maternal_imprinting1.95418064
33MP0001944_abnormal_pancreas_morphology1.92280346
34MP0009780_abnormal_chondrocyte_physiolo1.90796743
35MP0002909_abnormal_adrenal_gland1.87434931
36MP0010234_abnormal_vibrissa_follicle1.82267045
37MP0003300_gastrointestinal_ulcer1.80355424
38MP0005395_other_phenotype1.73537888
39MP0002138_abnormal_hepatobiliary_system1.71497884
40MP0005645_abnormal_hypothalamus_physiol1.70288549
41MP0002102_abnormal_ear_morphology1.63763786
42MP0004885_abnormal_endolymph1.60573031
43MP0005332_abnormal_amino_acid1.56787959
44MP0000462_abnormal_digestive_system1.56214390
45MP0005220_abnormal_exocrine_pancreas1.54755022
46MP0005257_abnormal_intraocular_pressure1.54355427
47MP0003279_aneurysm1.51233961
48MP0000579_abnormal_nail_morphology1.51054363
49MP0004270_analgesia1.46061151
50MP0010352_gastrointestinal_tract_polyps1.44495916
51MP0002277_abnormal_respiratory_mucosa1.44230366
52MP0003646_muscle_fatigue1.43056939
53MP0000013_abnormal_adipose_tissue1.42691656
54MP0005551_abnormal_eye_electrophysiolog1.42361112
55MP0010386_abnormal_urinary_bladder1.36546028
56MP0004133_heterotaxia1.35574006
57MP0005075_abnormal_melanosome_morpholog1.34415174
58MP0003091_abnormal_cell_migration1.34052504
59MP0003699_abnormal_female_reproductive1.33272986
60MP0003121_genomic_imprinting1.31455652
61MP0008438_abnormal_cutaneous_collagen1.29335462
62MP0001765_abnormal_ion_homeostasis1.29230911
63MP0002089_abnormal_postnatal_growth/wei1.28421443
64MP0002160_abnormal_reproductive_system1.28420769
65MP0003868_abnormal_feces_composition1.28114811
66MP0005636_abnormal_mineral_homeostasis1.27227789
67MP0001299_abnormal_eye_distance/1.24444403
68MP0001756_abnormal_urination1.24425814
69MP0005389_reproductive_system_phenotype1.23926238
70MP0003123_paternal_imprinting1.22993858
71MP0001915_intracranial_hemorrhage1.21642465
72MP0005253_abnormal_eye_physiology1.21615861
73MP0002938_white_spotting1.21199206
74MP0001501_abnormal_sleep_pattern1.20931206
75MP0001984_abnormal_olfaction1.19786173
76MP0009053_abnormal_anal_canal1.19304495
77MP0002638_abnormal_pupillary_reflex1.18663681
78MP0008872_abnormal_physiological_respon1.18489879
79MP0003950_abnormal_plasma_membrane1.14774102
80MP0002078_abnormal_glucose_homeostasis1.14736172
81MP0003806_abnormal_nucleotide_metabolis1.12577040
82MP0005647_abnormal_sex_gland1.11813120
83MP0003195_calcinosis1.11306639
84MP0005084_abnormal_gallbladder_morpholo1.11009317
85MP0001881_abnormal_mammary_gland1.09212292
86MP0004019_abnormal_vitamin_homeostasis1.08485412
87MP0010030_abnormal_orbit_morphology1.08068073
88MP0005187_abnormal_penis_morphology1.07304577
89MP0005448_abnormal_energy_balance1.05576806
90MP0004043_abnormal_pH_regulation1.04590799
91MP0001119_abnormal_female_reproductive1.02591682
92MP0000631_abnormal_neuroendocrine_gland1.01915285
93MP0003045_fibrosis1.01850465
94MP0003011_delayed_dark_adaptation1.01785297
95MP0001986_abnormal_taste_sensitivity1.01032918
96MP0000609_abnormal_liver_physiology1.00979653
97MP0009745_abnormal_behavioral_response1.00233465
98MP0002168_other_aberrant_phenotype0.99338343
99MP0002295_abnormal_pulmonary_circulatio0.97872286
100MP0000427_abnormal_hair_cycle0.97387190
101MP0003937_abnormal_limbs/digits/tail_de0.97317143
102MP0003453_abnormal_keratinocyte_physiol0.97045737
103MP0001968_abnormal_touch/_nociception0.96733633
104MP0009643_abnormal_urine_homeostasis0.96316194
105MP0009046_muscle_twitch0.96170715
106MP0001485_abnormal_pinna_reflex0.95589763
107MP0003119_abnormal_digestive_system0.95332605
108MP0005248_abnormal_Harderian_gland0.94313430
109MP0005535_abnormal_body_temperature0.94157785
110MP0000230_abnormal_systemic_arterial0.93634975
111MP0002118_abnormal_lipid_homeostasis0.92446235
112MP0001502_abnormal_circadian_rhythm0.92364863
113MP0000647_abnormal_sebaceous_gland0.90143898
114MP0005023_abnormal_wound_healing0.88764353
115MP0001905_abnormal_dopamine_level0.88334259
116MP0002877_abnormal_melanocyte_morpholog0.88124696
117MP0006292_abnormal_olfactory_placode0.87139814
118MP0003566_abnormal_cell_adhesion0.84624253
119MP0000767_abnormal_smooth_muscle0.84440146
120MP0001764_abnormal_homeostasis0.84140566
121MP0001188_hyperpigmentation0.84004107
122MP0005174_abnormal_tail_pigmentation0.83702218
123MP0005503_abnormal_tendon_morphology0.83352662
124MP0000538_abnormal_urinary_bladder0.83269482
125* MP0003953_abnormal_hormone_level0.81858956
126MP0002272_abnormal_nervous_system0.81764369
127MP0001849_ear_inflammation0.80572906
128MP0003724_increased_susceptibility_to0.80355853
129MP0005508_abnormal_skeleton_morphology0.78625070
130MP0004272_abnormal_basement_membrane0.76407892
131MP0006054_spinal_hemorrhage0.76192493
132MP0002090_abnormal_vision0.75849254
133MP0010678_abnormal_skin_adnexa0.75713701
134MP0000613_abnormal_salivary_gland0.75085952
135MP0010368_abnormal_lymphatic_system0.74801747
136MP0002896_abnormal_bone_mineralization0.74468195
137MP0002734_abnormal_mechanical_nocicepti0.74193808
138MP0000627_abnormal_mammary_gland0.74068367
139MP0004147_increased_porphyrin_level0.73666588
140MP0008004_abnormal_stomach_pH0.72199503
141MP0004142_abnormal_muscle_tone0.72115068
142MP0002932_abnormal_joint_morphology0.71007521
143MP0003755_abnormal_palate_morphology0.70501252
144MP0004215_abnormal_myocardial_fiber0.70471118
145MP0001919_abnormal_reproductive_system0.70071359
146* MP0002557_abnormal_social/conspecific_i0.69699452
147MP0003115_abnormal_respiratory_system0.69152491
148MP0000428_abnormal_craniofacial_morphol0.68926652
149MP0001970_abnormal_pain_threshold0.67563866
150MP0001346_abnormal_lacrimal_gland0.67459630
151MP0005666_abnormal_adipose_tissue0.67425445
152MP0003890_abnormal_embryonic-extraembry0.67163622
153MP0002064_seizures0.66982059
154MP0001243_abnormal_dermal_layer0.64959902
155MP0003183_abnormal_peptide_metabolism0.64651950
156MP0000569_abnormal_digit_pigmentation0.64208374
157MP0000537_abnormal_urethra_morphology0.63925346
158MP0002060_abnormal_skin_morphology0.61527894
159MP0002876_abnormal_thyroid_physiology0.60297841
160MP0000733_abnormal_muscle_development0.59820289
161MP0000163_abnormal_cartilage_morphology0.59542219
162MP0000467_abnormal_esophagus_morphology0.58797972
163MP0002928_abnormal_bile_duct0.57945666
164MP0002115_abnormal_skeleton_extremities0.56023443
165MP0003329_amyloid_beta_deposits0.55792760
166MP0005595_abnormal_vascular_smooth0.55755725
167MP0002249_abnormal_larynx_morphology0.55011698
168MP0009250_abnormal_appendicular_skeleto0.54838527
169MP0000432_abnormal_head_morphology0.54486673
170MP0001177_atelectasis0.54002341
171MP0000639_abnormal_adrenal_gland0.53862087

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)5.16835646
2Aplasia of the phalanges of the hand (HP:0009802)5.16835646
3Aplasia involving bones of the extremities (HP:0009825)5.16835646
4Hypoglycemic seizures (HP:0002173)4.93401913
5Alopecia of scalp (HP:0002293)4.77111071
6Hyperinsulinemic hypoglycemia (HP:0000825)4.44222738
7Hypoglycemic coma (HP:0001325)4.35855515
8Ketoacidosis (HP:0001993)4.19224627
9Deep venous thrombosis (HP:0002625)4.02298897
10Hypothermia (HP:0002045)3.89117804
11Abnormality of vitamin B metabolism (HP:0004340)3.83888075
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77904164
13Methylmalonic acidemia (HP:0002912)3.71307238
14Follicular hyperkeratosis (HP:0007502)3.59718746
15Symptomatic seizures (HP:0011145)3.57834865
16Onycholysis (HP:0001806)3.42659021
17Hypoalphalipoproteinemia (HP:0003233)3.39689855
18Hypolipoproteinemia (HP:0010981)3.34780611
19Neoplasm of the adrenal cortex (HP:0100641)3.34080434
20Hypobetalipoproteinemia (HP:0003563)3.30006116
21Abnormality of endocrine pancreas physiology (HP:0012093)3.20808327
22Abnormality of the pancreatic islet cells (HP:0006476)3.20808327
23Intrahepatic cholestasis (HP:0001406)3.20403679
24Methylmalonic aciduria (HP:0012120)3.17779846
25Ketosis (HP:0001946)3.17262407
26Hematochezia (HP:0002573)3.15745579
27Abnormality of proline metabolism (HP:0010907)3.15172298
28Hydroxyprolinuria (HP:0003080)3.15172298
29Abnormality of the vitamin B12 metabolism (HP:0004341)3.13110834
30Xanthomatosis (HP:0000991)3.11274640
31Thyroiditis (HP:0100646)3.06492661
32Protrusio acetabuli (HP:0003179)3.06282571
33Abnormality of nail color (HP:0100643)3.00424688
34Conjunctival hamartoma (HP:0100780)2.98737342
35Large for gestational age (HP:0001520)2.87986051
36Abnormal pancreas size (HP:0012094)2.86025708
37Abnormality of vitamin metabolism (HP:0100508)2.85005043
38Blepharitis (HP:0000498)2.84940996
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.83257520
40Acanthocytosis (HP:0001927)2.77705209
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74884097
42Cutaneous melanoma (HP:0012056)2.73764475
43Pancreatic fibrosis (HP:0100732)2.72775248
44Intestinal atresia (HP:0011100)2.71695739
45Pancreatic cysts (HP:0001737)2.70513571
46Progressive macrocephaly (HP:0004481)2.70403680
47Hypomagnesemia (HP:0002917)2.69555659
48Shallow orbits (HP:0000586)2.69035764
49Hamartoma of the eye (HP:0010568)2.65577726
50Premature rupture of membranes (HP:0001788)2.64974969
51Cortical dysplasia (HP:0002539)2.64429962
52Myocardial infarction (HP:0001658)2.62950609
53Malnutrition (HP:0004395)2.60726844
54Congenital stationary night blindness (HP:0007642)2.60468107
55Short hallux (HP:0010109)2.55568808
56Chronic hepatic failure (HP:0100626)2.53169577
57Furrowed tongue (HP:0000221)2.51048027
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44985460
59Abnormality of urine glucose concentration (HP:0011016)2.44465663
60Glycosuria (HP:0003076)2.44465663
61Peritonitis (HP:0002586)2.41871012
62True hermaphroditism (HP:0010459)2.39043782
63Biconcave vertebral bodies (HP:0004586)2.38428513
64Epidermoid cyst (HP:0200040)2.37439654
65Hemiparesis (HP:0001269)2.36621036
66Hyperglycemia (HP:0003074)2.33359876
67Hyperglycinemia (HP:0002154)2.32691470
68Hyperlipoproteinemia (HP:0010980)2.31189592
69Aortic dissection (HP:0002647)2.30828204
70Neoplasm of the adrenal gland (HP:0100631)2.30029954
71Abolished electroretinogram (ERG) (HP:0000550)2.29869342
72Neonatal short-limb short stature (HP:0008921)2.29161610
73Tetraparesis (HP:0002273)2.29107796
74Cervical subluxation (HP:0003308)2.28751638
75Mildly elevated creatine phosphokinase (HP:0008180)2.26899952
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26880481
77Aortic aneurysm (HP:0004942)2.25856184
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.25096090
79Agitation (HP:0000713)2.24962457
80Late onset (HP:0003584)2.24267765
81Ileus (HP:0002595)2.23578073
82Fat malabsorption (HP:0002630)2.20105879
83Abnormality of midbrain morphology (HP:0002418)2.18850843
84Molar tooth sign on MRI (HP:0002419)2.18850843
85Conjugated hyperbilirubinemia (HP:0002908)2.18603187
86Aplasia/Hypoplasia of the hallux (HP:0008362)2.16998683
87Depressed nasal tip (HP:0000437)2.15957151
88Acute necrotizing encephalopathy (HP:0006965)2.14369318
89Hypoalbuminemia (HP:0003073)2.14350388
90Abnormal albumin level (HP:0012116)2.14350388
91Hepatic necrosis (HP:0002605)2.13825334
92Abnormal rod and cone electroretinograms (HP:0008323)2.13090854
93Male infertility (HP:0003251)2.12079563
94Pancreatic islet-cell hyperplasia (HP:0004510)2.10633406
95Abnormality of secondary sexual hair (HP:0009888)2.08987320
96Abnormality of the axillary hair (HP:0100134)2.08987320
97Abnormality of magnesium homeostasis (HP:0004921)2.08023573
98Broad metatarsal (HP:0001783)2.07523119
99Prominent metopic ridge (HP:0005487)2.07431858
100Stomatitis (HP:0010280)2.06954490
101Aplasia/hypoplasia of the uterus (HP:0008684)2.06890409
102Congenital sensorineural hearing impairment (HP:0008527)2.06395131
103Nephronophthisis (HP:0000090)2.04934714
104Vascular tortuosity (HP:0004948)2.03790736
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03488895
106Meningioma (HP:0002858)2.02524404
107Abnormality of the renal cortex (HP:0011035)2.02016448
108Abnormal drinking behavior (HP:0030082)2.02007508
109Polydipsia (HP:0001959)2.02007508
110Abnormality of the middle phalanges of the toes (HP:0010183)2.01120689
111Hypoplasia of the fovea (HP:0007750)2.01026578
112Aplasia/Hypoplasia of the fovea (HP:0008060)2.01026578
113Aqueductal stenosis (HP:0002410)1.99738785
114Mitral valve prolapse (HP:0001634)1.98190116
115Increased circulating renin level (HP:0000848)1.97626155
116Pigmentary retinal degeneration (HP:0001146)1.97587504
117Infantile muscular hypotonia (HP:0008947)1.97488705
118Gaze-evoked nystagmus (HP:0000640)1.97464889
119Acute encephalopathy (HP:0006846)1.97065958
120Renal cortical cysts (HP:0000803)1.96697411
121Cubitus valgus (HP:0002967)1.95572848
122Medial flaring of the eyebrow (HP:0010747)1.95316683
123Short nail (HP:0001799)1.95182470
124Tarsal synostosis (HP:0008368)1.94689695
125Cardiovascular calcification (HP:0011915)1.94231904
126Arterial tortuosity (HP:0005116)1.93623376
127Hyperphosphatemia (HP:0002905)1.93461847
128Broad face (HP:0000283)1.92347771
129Progressive sensorineural hearing impairment (HP:0000408)1.91481503
130Tongue fasciculations (HP:0001308)1.90321892
131Type I diabetes mellitus (HP:0100651)1.89753625
132Goiter (HP:0000853)1.89727483
133Mitochondrial inheritance (HP:0001427)1.88409707
134Epileptiform EEG discharges (HP:0011182)1.87550549
135EEG with generalized epileptiform discharges (HP:0011198)1.85515326
136Abnormality of methionine metabolism (HP:0010901)1.85121405
137Abnormality of the nasal septum (HP:0000419)1.84140086
138Right ventricular cardiomyopathy (HP:0011663)1.83621084
139Turricephaly (HP:0000262)1.83077277
140Synostosis involving the elbow (HP:0003938)1.83009328
141Humeroradial synostosis (HP:0003041)1.83009328
142Abnormality of serine family amino acid metabolism (HP:0010894)1.82371883
143Abnormality of glycine metabolism (HP:0010895)1.82371883
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81134205
145Dicarboxylic aciduria (HP:0003215)1.81134205
146Coronal craniosynostosis (HP:0004440)1.78673434
147Chorioretinal atrophy (HP:0000533)1.78444732
1483-Methylglutaconic aciduria (HP:0003535)1.77719613
149Papillary thyroid carcinoma (HP:0002895)1.77634049
150Synostosis involving bones of the lower limbs (HP:0009138)1.76616289
151Synostosis involving bones of the feet (HP:0009140)1.76616289
152Hypsarrhythmia (HP:0002521)1.76112833
153Hypoplasia of the uterus (HP:0000013)1.75772074
154Lethargy (HP:0001254)1.75680143
155Long nose (HP:0003189)1.75548303
156Pendular nystagmus (HP:0012043)1.75190013
157Hyperthyroidism (HP:0000836)1.74401358
158Urethral obstruction (HP:0000796)1.73589539
159Facial shape deformation (HP:0011334)1.73168115
160Potter facies (HP:0002009)1.73168115
161Abnormality of the renal medulla (HP:0100957)1.72899224
162Abnormality of the metopic suture (HP:0005556)1.72863237
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72824633
164Hypoplastic toenails (HP:0001800)1.72724054
165Short middle phalanx of the 5th finger (HP:0004220)1.72204218
166Atrophic scars (HP:0001075)1.71946457
167Male pseudohermaphroditism (HP:0000037)1.71921917
168Insulin-resistant diabetes mellitus (HP:0000831)1.70448638
169Enlarged penis (HP:0000040)1.70442459
170Confusion (HP:0001289)1.69069573
171Vascular calcification (HP:0004934)1.69051651
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.68624048
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68135755
174Ectopia lentis (HP:0001083)1.66915046
175Fibular aplasia (HP:0002990)1.66570368
176Skin nodule (HP:0200036)1.66171294
177Abnormality of homocysteine metabolism (HP:0010919)1.64620836
178Homocystinuria (HP:0002156)1.64620836
179Bronchomalacia (HP:0002780)1.63959496
180Dilatation of the ascending aorta (HP:0005111)1.63822970
181Abnormality of purine metabolism (HP:0004352)1.61655987
182Craniofacial hyperostosis (HP:0004493)1.61489660
183Abnormality of incisor morphology (HP:0011063)1.59153649
184Abnormality of the common coagulation pathway (HP:0010990)1.58500471
185Genu recurvatum (HP:0002816)1.57337027
186Abnormal gallbladder physiology (HP:0012438)1.56960075
187Cholecystitis (HP:0001082)1.56960075
188Mitral stenosis (HP:0001718)1.56608567
189Hyperglycinuria (HP:0003108)1.56171064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.65479485
2LATS14.84876908
3MKNK24.69727027
4TNIK4.64830321
5TAOK33.13799524
6GRK12.89770859
7RIPK12.80979682
8ACVR1B2.60135568
9FRK2.52581734
10TRIB32.51828473
11MST42.42543823
12MOS2.39850766
13ERBB42.31583369
14LATS22.29852164
15MKNK12.28212172
16ADRBK22.17274040
17MAP4K21.98748522
18OXSR11.90166730
19PHKG11.85433301
20PHKG21.85433301
21STK38L1.81527952
22STK391.79431582
23ZAK1.78938603
24PINK11.76607171
25PASK1.69825509
26NUAK11.69763523
27STK31.53499680
28TRIM281.50196061
29CASK1.48898078
30LMTK21.40246823
31BMPR21.37222408
32STK241.33800170
33NTRK11.32917661
34PRKD31.32169761
35EPHA21.31487221
36EIF2AK31.31407426
37MAP2K71.30576012
38PIK3CA1.29747875
39DAPK21.28038981
40MAP3K41.26820599
41TTK1.26231270
42MAP3K61.25191367
43SIK11.22652913
44DDR21.22389759
45TAOK11.17476027
46STK101.16813814
47BMX1.16072483
48WNK41.13509977
49PLK31.13300355
50INSRR1.12909452
51TXK1.08640238
52PRKCE1.08072577
53TEC1.07871669
54KSR21.07829139
55MAP3K131.06131388
56PTK21.01537994
57BCKDK1.00250313
58ERBB30.99630810
59CSNK1G10.98108036
60PTK60.95628349
61PAK60.93068546
62MAP3K120.90920331
63TIE10.89856340
64IRAK10.89553698
65MST1R0.88646117
66ERN10.86663441
67PRKAA20.84781561
68PAK30.84401109
69BRAF0.83735004
70RET0.83538661
71PDGFRA0.78932517
72PLK20.78890147
73FER0.77284517
74MAP2K40.72814061
75NTRK30.72227243
76IKBKB0.70138539
77MAP3K90.69412112
78STK110.69290900
79BRSK20.69045107
80MAP3K80.67309964
81AKT30.67296619
82CSNK1G30.66172804
83TLK10.64872236
84HIPK20.63776664
85EPHA40.63642459
86ITK0.63092700
87MAP2K60.62972981
88PRKG20.62750492
89NTRK20.62114470
90EPHA30.61896203
91SGK30.60799952
92GRK70.60153449
93EEF2K0.59661860
94STK380.59607494
95MAPK130.58061560
96FGFR20.57093973
97ADRBK10.55696970
98MET0.53251243
99KSR10.53005304
100TRPM70.51260187
101PRKCQ0.51088897
102PRKAA10.49207956
103MAPKAPK30.49001272
104MELK0.48530365
105MAP2K10.48335539
106DMPK0.48172922
107STK160.47659005
108FGFR40.47434105
109BMPR1B0.46947310
110CHEK20.46934540
111LIMK10.45758396
112CAMK2D0.45570185
113FGFR10.44625602
114NLK0.44466019
115MAP3K20.44104386
116ROCK10.44092332
117JAK10.43780904
118MYLK0.43525045
119PRKCI0.42548369
120SGK20.42512468
121LRRK20.41940014
122PKN20.41550636
123CDK90.41324788
124TYRO30.40869719
125PLK40.40410520
126IKBKE0.40191008
127PAK20.39734961
128WNK30.39135025
129RAF10.38854814
130VRK10.38674578
131MAPK70.37934775
132CAMK2A0.37857538
133MAP3K70.37596150
134PRKACA0.37582207
135MAP3K10.37212077
136PRKCA0.36945105
137NEK90.35285850
138CSNK1A10.35272180
139ERBB20.34694824
140STK40.34485501
141RPS6KA40.33292574
142YES10.33227898
143PRKD20.32811525
144PRKCG0.30990915
145MTOR0.30766992
146CDK80.30417652
147FGFR30.30141366
148SGK10.29508769
149CAMKK20.29416812
150PLK10.28892322
151EPHB20.28861602
152CSNK1G20.28710982
153EGFR0.28579410
154IGF1R0.28469899
155MAPK110.28435955
156MAPK120.27052949
157PRKG10.26018441
158MAP3K100.25902157
159TTN0.24961569
160PTK2B0.24522504
161PRKACG0.24151139
162TYK20.23648778
163FLT30.23338180

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.18207038
2Protein export_Homo sapiens_hsa030602.85722780
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51644783
4Vitamin digestion and absorption_Homo sapiens_hsa049772.47080289
5Arginine biosynthesis_Homo sapiens_hsa002202.39726588
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.30423061
7Fat digestion and absorption_Homo sapiens_hsa049752.28202793
8Vitamin B6 metabolism_Homo sapiens_hsa007502.11525030
9Bile secretion_Homo sapiens_hsa049761.99743778
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98097629
11Circadian rhythm_Homo sapiens_hsa047101.95279643
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94753800
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90706833
14Fatty acid biosynthesis_Homo sapiens_hsa000611.89442493
15Mineral absorption_Homo sapiens_hsa049781.86828373
16Fatty acid degradation_Homo sapiens_hsa000711.80595438
17PPAR signaling pathway_Homo sapiens_hsa033201.77857003
18Caffeine metabolism_Homo sapiens_hsa002321.76215651
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72344172
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66686216
21Ovarian steroidogenesis_Homo sapiens_hsa049131.65132070
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64949696
23Linoleic acid metabolism_Homo sapiens_hsa005911.63265290
24Tryptophan metabolism_Homo sapiens_hsa003801.61529639
25Type I diabetes mellitus_Homo sapiens_hsa049401.57470659
26Complement and coagulation cascades_Homo sapiens_hsa046101.57265210
27Phototransduction_Homo sapiens_hsa047441.55206441
28Fatty acid elongation_Homo sapiens_hsa000621.52095213
29Starch and sucrose metabolism_Homo sapiens_hsa005001.47260206
30Fatty acid metabolism_Homo sapiens_hsa012121.45034065
31Histidine metabolism_Homo sapiens_hsa003401.45009456
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43239081
33Oxidative phosphorylation_Homo sapiens_hsa001901.42864334
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.38763260
35Arginine and proline metabolism_Homo sapiens_hsa003301.38459645
36Collecting duct acid secretion_Homo sapiens_hsa049661.33807740
37Steroid biosynthesis_Homo sapiens_hsa001001.33626043
38Propanoate metabolism_Homo sapiens_hsa006401.29273324
39Renin-angiotensin system_Homo sapiens_hsa046141.29005705
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27126105
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.24871193
42Folate biosynthesis_Homo sapiens_hsa007901.24122282
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23281736
44Type II diabetes mellitus_Homo sapiens_hsa049301.22639973
45Ether lipid metabolism_Homo sapiens_hsa005651.21592338
46Sulfur metabolism_Homo sapiens_hsa009201.21522649
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19149297
48Regulation of autophagy_Homo sapiens_hsa041401.16937727
49Lysine degradation_Homo sapiens_hsa003101.15653276
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10991093
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08098125
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04128065
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03369638
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02520938
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01564308
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98918155
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.98709937
58Adherens junction_Homo sapiens_hsa045200.98694942
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95140545
60Renin secretion_Homo sapiens_hsa049240.94447080
61ABC transporters_Homo sapiens_hsa020100.92931700
62Protein digestion and absorption_Homo sapiens_hsa049740.92037631
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90605582
64TGF-beta signaling pathway_Homo sapiens_hsa043500.88360127
65Chemical carcinogenesis_Homo sapiens_hsa052040.87501964
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86753954
67Arachidonic acid metabolism_Homo sapiens_hsa005900.85978244
68Dorso-ventral axis formation_Homo sapiens_hsa043200.85546161
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85481499
70Bladder cancer_Homo sapiens_hsa052190.85452984
71Peroxisome_Homo sapiens_hsa041460.82104268
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.76589741
73Glycerolipid metabolism_Homo sapiens_hsa005610.74858783
74ECM-receptor interaction_Homo sapiens_hsa045120.74458704
75Serotonergic synapse_Homo sapiens_hsa047260.74332483
76Retinol metabolism_Homo sapiens_hsa008300.73747596
77Selenocompound metabolism_Homo sapiens_hsa004500.71812547
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70683734
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69776485
80beta-Alanine metabolism_Homo sapiens_hsa004100.69697474
81Galactose metabolism_Homo sapiens_hsa000520.69241416
82Sphingolipid metabolism_Homo sapiens_hsa006000.68974535
83Biosynthesis of amino acids_Homo sapiens_hsa012300.68460471
84RNA degradation_Homo sapiens_hsa030180.67560067
85Parkinsons disease_Homo sapiens_hsa050120.60832931
86Pancreatic cancer_Homo sapiens_hsa052120.60231433
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59823089
88MicroRNAs in cancer_Homo sapiens_hsa052060.59394631
89Butanoate metabolism_Homo sapiens_hsa006500.57559934
90Fructose and mannose metabolism_Homo sapiens_hsa000510.57411368
91* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57202367
92Thyroid hormone synthesis_Homo sapiens_hsa049180.57119107
93* Metabolic pathways_Homo sapiens_hsa011000.56819421
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.56347586
95Focal adhesion_Homo sapiens_hsa045100.54805925
96mTOR signaling pathway_Homo sapiens_hsa041500.53116926
97Circadian entrainment_Homo sapiens_hsa047130.52984370
98p53 signaling pathway_Homo sapiens_hsa041150.52761824
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52260295
100GnRH signaling pathway_Homo sapiens_hsa049120.52257058
101Alzheimers disease_Homo sapiens_hsa050100.51751928
102Proteasome_Homo sapiens_hsa030500.51119729
103Basal transcription factors_Homo sapiens_hsa030220.49853003
104Proteoglycans in cancer_Homo sapiens_hsa052050.49246053
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49109060
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49106944
107Small cell lung cancer_Homo sapiens_hsa052220.49066614
108Melanoma_Homo sapiens_hsa052180.48143901
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47514320
110Pancreatic secretion_Homo sapiens_hsa049720.47164382
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46328791
112Amoebiasis_Homo sapiens_hsa051460.45929702
113RNA polymerase_Homo sapiens_hsa030200.45876050
114Taste transduction_Homo sapiens_hsa047420.45768299
115Amphetamine addiction_Homo sapiens_hsa050310.45721992
116Insulin resistance_Homo sapiens_hsa049310.45447197
117Insulin secretion_Homo sapiens_hsa049110.44169690
118Salivary secretion_Homo sapiens_hsa049700.43461484
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43343437
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42874194
121ErbB signaling pathway_Homo sapiens_hsa040120.41829661
122Hippo signaling pathway_Homo sapiens_hsa043900.41504189
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40562696
124Nicotine addiction_Homo sapiens_hsa050330.40226871
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39078532
126Pyruvate metabolism_Homo sapiens_hsa006200.38140137
127Glucagon signaling pathway_Homo sapiens_hsa049220.37918244
128Homologous recombination_Homo sapiens_hsa034400.37730435
129Glutathione metabolism_Homo sapiens_hsa004800.36572212
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36384768
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35961276
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35066019
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.35031945
134Dilated cardiomyopathy_Homo sapiens_hsa054140.34978322
135Dopaminergic synapse_Homo sapiens_hsa047280.34957791
136Purine metabolism_Homo sapiens_hsa002300.33861508
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33680560
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.33290473
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32987785
140TNF signaling pathway_Homo sapiens_hsa046680.32743239
141Glioma_Homo sapiens_hsa052140.31857042
142Rheumatoid arthritis_Homo sapiens_hsa053230.31129479
143Choline metabolism in cancer_Homo sapiens_hsa052310.30965793
144African trypanosomiasis_Homo sapiens_hsa051430.30602452
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30142876
146Phenylalanine metabolism_Homo sapiens_hsa003600.28591761
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28181093
148Primary immunodeficiency_Homo sapiens_hsa053400.27965534
149Intestinal immune network for IgA production_Homo sapiens_hsa046720.26392531

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