ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.68264804
2	lipopolysaccharide biosynthetic process (GO:0009103)	9.39300089
3	protein-chromophore linkage (GO:0018298)	9.05531892
4	DNA methylation involved in gamete generation (GO:0043046)	8.89964186
5	lipopolysaccharide metabolic process (GO:0008653)	8.28257166
6	regulation of meiosis I (GO:0060631)	8.19656615
7	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.86888292
8	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.77794576
9	regulation of protein glycosylation (GO:0060049)	7.73962979
10	regulation of pigment cell differentiation (GO:0050932)	7.47250368
11	sulfate transmembrane transport (GO:1902358)	7.46823789
12	paraxial mesoderm development (GO:0048339)	7.42485758
13	positive regulation of developmental pigmentation (GO:0048087)	7.34600167
14	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	7.10773249
15	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.88761621
16	sulfate transport (GO:0008272)	6.34449769
17	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.11410151
18	L-phenylalanine catabolic process (GO:0006559)	6.11410151
19	piRNA metabolic process (GO:0034587)	6.10513759
20	negative regulation of glycoprotein metabolic process (GO:1903019)	5.97462458
21	SMAD protein complex assembly (GO:0007183)	5.85919153
22	notochord development (GO:0030903)	5.80213966
23	tyrosine metabolic process (GO:0006570)	5.46893783
24	heme transport (GO:0015886)	5.41747355
25	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.28345364
26	L-phenylalanine metabolic process (GO:0006558)	5.28345364
27	ribonucleoprotein complex disassembly (GO:0032988)	5.16185015
28	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.86671027
29	nodal signaling pathway (GO:0038092)	4.72564970
30	regulation of transforming growth factor beta2 production (GO:0032909)	4.64859471
31	negative regulation of stem cell proliferation (GO:2000647)	4.61173944
32	positive regulation of meiosis (GO:0045836)	4.56377472
33	centriole replication (GO:0007099)	4.55609875
34	meiotic chromosome segregation (GO:0045132)	4.45838449
35	serotonin receptor signaling pathway (GO:0007210)	4.38916047
36	regulation of interleukin-5 production (GO:0032674)	4.30332838
37	regulation of odontogenesis (GO:0042481)	4.29712892
38	germinal center formation (GO:0002467)	4.29307598
39	response to mercury ion (GO:0046689)	4.26299994
40	protein retention in ER lumen (GO:0006621)	4.25316728
41	positive regulation of meiotic cell cycle (GO:0051446)	4.22909953
42	glycerol metabolic process (GO:0006071)	4.14025400
43	cellular response to gamma radiation (GO:0071480)	4.06240126
44	organelle disassembly (GO:1903008)	4.05973398
45	vitamin transmembrane transport (GO:0035461)	4.03291154
46	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.01978039
47	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.00276803
48	DNA damage induced protein phosphorylation (GO:0006975)	3.97801506
49	iron coordination entity transport (GO:1901678)	3.88437814
50	response to epinephrine (GO:0071871)	3.86661521
51	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.84557287
52	flavonoid metabolic process (GO:0009812)	3.79461264
53	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.77773841
54	embryonic process involved in female pregnancy (GO:0060136)	3.75995466
55	heart valve formation (GO:0003188)	3.71902146
56	tachykinin receptor signaling pathway (GO:0007217)	3.71512689
57	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.69428438
58	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.68288149
59	alditol metabolic process (GO:0019400)	3.66414290
60	pantothenate metabolic process (GO:0015939)	3.66206156
61	aromatic amino acid family catabolic process (GO:0009074)	3.65655844
62	regulation of developmental pigmentation (GO:0048070)	3.64520023
63	rhodopsin mediated signaling pathway (GO:0016056)	3.64442312
64	negative regulation of neural precursor cell proliferation (GO:2000178)	3.60751681
65	sulfur compound transport (GO:0072348)	3.59937070
66	toxin metabolic process (GO:0009404)	3.57836639
67	negative regulation of cell-matrix adhesion (GO:0001953)	3.57318249
68	sympathetic nervous system development (GO:0048485)	3.42185813
69	inflammatory response to antigenic stimulus (GO:0002437)	3.39147109
70	lysine metabolic process (GO:0006553)	3.38344361
71	lysine catabolic process (GO:0006554)	3.38344361
72	aspartate family amino acid catabolic process (GO:0009068)	3.36385539
73	urate metabolic process (GO:0046415)	3.24851548
74	regulation of keratinocyte proliferation (GO:0010837)	3.22966735
75	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.20779407
76	uterus development (GO:0060065)	3.20076571
77	organ induction (GO:0001759)	3.18790213
78	regulation of hair follicle development (GO:0051797)	3.13337729
79	aromatic amino acid family metabolic process (GO:0009072)	3.12066158
80	regulation of translational termination (GO:0006449)	3.11557339
81	polyol biosynthetic process (GO:0046173)	3.09632656
82	somite rostral/caudal axis specification (GO:0032525)	3.04334189
83	centriole assembly (GO:0098534)	3.04260898
84	DNA methylation (GO:0006306)	3.02228222
85	DNA alkylation (GO:0006305)	3.02228222
86	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.97073935
87	biotin metabolic process (GO:0006768)	2.95952238
88	regulation of SMAD protein import into nucleus (GO:0060390)	2.93778779
89	negative regulation of BMP signaling pathway (GO:0030514)	2.92776175
90	membrane lipid biosynthetic process (GO:0046467)	2.84544279
91	sphingolipid biosynthetic process (GO:0030148)	2.84229052
92	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.83147351
93	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.82181198
94	regulation of metanephros development (GO:0072215)	2.81323827
95	cofactor transport (GO:0051181)	2.80956455
96	positive regulation of fatty acid oxidation (GO:0046321)	2.79521959
97	oogenesis (GO:0048477)	2.77343679
98	sphingosine metabolic process (GO:0006670)	17.7092478
99	diol metabolic process (GO:0034311)	16.0158869
100	sphingoid metabolic process (GO:0046519)	14.2405671

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	5.48500082
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.20400962
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.62448871
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.55223526
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.46749708
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.06936392
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.96609102
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.66265846
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29153172
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.22939424
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.22108211
12	P300_19829295_ChIP-Seq_ESCs_Human	2.16862975
13	EGR1_19032775_ChIP-ChIP_M12_Human	2.09164280
14	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	2.02161516
15	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.91052264
16	SOX2_19829295_ChIP-Seq_ESCs_Human	1.86621158
17	NANOG_19829295_ChIP-Seq_ESCs_Human	1.86621158
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84895743
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.83838443
20	HOXB7_26014856_ChIP-Seq_BT474_Human	1.80349374
21	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.80049034
22	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.77248358
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.75721496
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.75617394
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74560563
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73995362
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.73995362
28	STAT1_20625510_ChIP-Seq_HELA_Human	1.69837272
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58405675
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55784675
31	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.55371908
32	TCF4_23295773_ChIP-Seq_U87_Human	1.51278380
33	STAT3_23295773_ChIP-Seq_U87_Human	1.45730454
34	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44335156
35	OCT4_20526341_ChIP-Seq_ESCs_Human	1.41663367
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40731189
37	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.37897068
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37387560
39	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.36341940
40	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.36045771
41	AR_25329375_ChIP-Seq_VCAP_Human	1.35940167
42	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34948076
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32002474
44	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.31692567
45	VDR_22108803_ChIP-Seq_LS180_Human	1.30995416
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.30501192
47	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.29780387
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27571944
49	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.27529322
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26981224
51	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.26465232
52	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.26366595
53	AR_19668381_ChIP-Seq_PC3_Human	1.24527409
54	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23876476
55	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.22081745
56	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.20832974
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20679306
58	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20256653
59	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.15286135
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14651931
61	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.14560581
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13491236
63	NCOR_22424771_ChIP-Seq_293T_Human	1.12984888
64	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.11711204
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11610383
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11531389
67	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.10603701
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09658966
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06464912
70	CEBPB_22108803_ChIP-Seq_LS180_Human	1.05289575
71	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05167556
72	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05142573
73	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.04635983
74	STAT1_17558387_ChIP-Seq_HELA_Human	1.03806202
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03334013
76	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03334013
77	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03281719
78	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03273775
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03081636
80	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02380515
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02106631
82	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.01933429
83	TP53_16413492_ChIP-PET_HCT116_Human	1.00134180
84	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99625993
85	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99188221
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.98998836
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98829872
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98820851
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98760254
90	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.97375877
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96434934
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.95794915
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95557839
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.95557839
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95174294
96	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.95149079
97	TP63_23658742_ChIP-Seq_EP156T_Human	0.93377916
98	CJUN_26792858_Chip-Seq_BT549_Human	0.92754361
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.90415728
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90167701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.50891798
2	MP0003136_yellow_coat_color	8.08203811
3	MP0005171_absent_coat_pigmentation	7.62646472
4	MP0002653_abnormal_ependyma_morphology	5.92716829
5	MP0003045_fibrosis	4.64104179
6	MP0003890_abnormal_embryonic-extraembry	4.60016356
7	MP0003646_muscle_fatigue	4.05786846
8	MP0003879_abnormal_hair_cell	3.32048085
9	MP0000569_abnormal_digit_pigmentation	3.26616963
10	MP0004381_abnormal_hair_follicle	3.08384280
11	MP0002138_abnormal_hepatobiliary_system	2.43184401
12	MP0005670_abnormal_white_adipose	2.27384749
13	MP0005085_abnormal_gallbladder_physiolo	2.17338802
14	MP0003705_abnormal_hypodermis_morpholog	2.17207595
15	MP0000749_muscle_degeneration	2.11732059
16	MP0005075_abnormal_melanosome_morpholog	2.06060196
17	MP0002168_other_aberrant_phenotype	1.95092053
18	MP0004147_increased_porphyrin_level	1.88486264
19	MP0002938_white_spotting	1.84225378
20	MP0010352_gastrointestinal_tract_polyps	1.68907802
21	MP0003195_calcinosis	1.46727471
22	MP0005365_abnormal_bile_salt	1.43658796
23	MP0002095_abnormal_skin_pigmentation	1.33303152
24	MP0002075_abnormal_coat/hair_pigmentati	1.30035422
25	MP0004233_abnormal_muscle_weight	1.21990981
26	MP0005395_other_phenotype	1.11382059
27	MP0002160_abnormal_reproductive_system	1.06513096
28	MP0005174_abnormal_tail_pigmentation	1.03071052
29	MP0003137_abnormal_impulse_conducting	1.02203965
30	MP0005330_cardiomyopathy	0.98186505
31	MP0006054_spinal_hemorrhage	0.97811223
32	MP0002269_muscular_atrophy	0.94821279
33	MP0001186_pigmentation_phenotype	0.93489527
34	MP0003300_gastrointestinal_ulcer	0.89185517
35	MP0002735_abnormal_chemical_nociception	0.83040913
36	MP0001501_abnormal_sleep_pattern	0.81582088
37	MP0003252_abnormal_bile_duct	0.79789077
38	MP0004043_abnormal_pH_regulation	0.76482241
39	MP0002254_reproductive_system_inflammat	0.74622023
40	MP0000427_abnormal_hair_cycle	0.73079487
41	MP0000015_abnormal_ear_pigmentation	0.70483029
42	MP0001984_abnormal_olfaction	0.67426895
43	MP0005319_abnormal_enzyme/_coenzyme	0.65918609
44	MP0001324_abnormal_eye_pigmentation	0.65367641
45	MP0005076_abnormal_cell_differentiation	0.62573235
46	MP0000534_abnormal_ureter_morphology	0.60241242
47	MP0008770_decreased_survivor_rate	0.59832451
48	MP0002332_abnormal_exercise_endurance	0.56895513
49	MP0005377_hearing/vestibular/ear_phenot	0.55213960
50	MP0003878_abnormal_ear_physiology	0.55213960
51	MP0008569_lethality_at_weaning	0.54938920
52	MP0002272_abnormal_nervous_system	0.52203251
53	MP0001486_abnormal_startle_reflex	0.50926219
54	MP0002971_abnormal_brown_adipose	0.50373231
55	MP0002876_abnormal_thyroid_physiology	0.50075243
56	MP0003950_abnormal_plasma_membrane	0.49077341
57	MP0009764_decreased_sensitivity_to	0.47908091
58	MP0002396_abnormal_hematopoietic_system	0.47076436
59	MP0004130_abnormal_muscle_cell	0.45386703
60	MP0005389_reproductive_system_phenotype	0.44007937
61	MP0001970_abnormal_pain_threshold	0.43655504
62	MP0001661_extended_life_span	0.43019749
63	MP0009115_abnormal_fat_cell	0.40756908
64	MP0002277_abnormal_respiratory_mucosa	0.40702136
65	MP0002928_abnormal_bile_duct	0.38541109
66	MP0009745_abnormal_behavioral_response	0.37483667
67	MP0005410_abnormal_fertilization	0.35928452
68	MP0003937_abnormal_limbs/digits/tail_de	0.35608291
69	MP0008874_decreased_physiological_sensi	0.34197247
70	MP0010307_abnormal_tumor_latency	0.33843286
71	MP0003183_abnormal_peptide_metabolism	0.33170684
72	MP0002751_abnormal_autonomic_nervous	0.32940114
73	MP0002229_neurodegeneration	0.32130466
74	MP0009046_muscle_twitch	0.30818315
75	MP0002733_abnormal_thermal_nociception	0.30331579
76	MP0005551_abnormal_eye_electrophysiolog	0.29420192
77	MP0000377_abnormal_hair_follicle	0.28894312
78	MP0003959_abnormal_lean_body	0.28618970
79	MP0004484_altered_response_of	0.28468131
80	MP0003632_abnormal_nervous_system	0.28026494
81	MP0002064_seizures	0.27880553
82	MP0004142_abnormal_muscle_tone	0.27607778
83	MP0002106_abnormal_muscle_physiology	0.26932238
84	MP0008875_abnormal_xenobiotic_pharmacok	0.26061019
85	MP0003763_abnormal_thymus_physiology	0.25197458
86	MP0005266_abnormal_metabolism	0.24514306
87	MP0002572_abnormal_emotion/affect_behav	0.24360754
88	MP0008872_abnormal_physiological_respon	0.24353758
89	MP0001800_abnormal_humoral_immune	0.23327195
90	MP0000026_abnormal_inner_ear	0.22152460
91	MP0000470_abnormal_stomach_morphology	0.22061664
92	MP0005646_abnormal_pituitary_gland	0.22025666
93	MP0008932_abnormal_embryonic_tissue	0.21628080
94	MP0003385_abnormal_body_wall	0.21244652
95	MP0005387_immune_system_phenotype	0.20267413
96	MP0001790_abnormal_immune_system	0.20267413
97	MP0000367_abnormal_coat/_hair	0.19724029
98	MP0005451_abnormal_body_composition	0.19264899
99	MP0005448_abnormal_energy_balance	0.18766716
100	MP0002083_premature_death	0.16734344

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	9.91777181
2	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.96220224
3	Acanthocytosis (HP:0001927)	7.94949328
4	Parakeratosis (HP:0001036)	7.35903344
5	Aplastic anemia (HP:0001915)	6.42852891
6	Dialeptic seizures (HP:0011146)	4.98280390
7	Proximal amyotrophy (HP:0007126)	4.91642647
8	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.62990917
9	Vertebral arch anomaly (HP:0008438)	4.60430497
10	Rectal prolapse (HP:0002035)	4.55539535
11	Congenital ichthyosiform erythroderma (HP:0007431)	4.53449182
12	Spontaneous hematomas (HP:0007420)	4.49144635
13	Colon cancer (HP:0003003)	4.48468992
14	Hematochezia (HP:0002573)	4.31249980
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.12697492
16	Scapular winging (HP:0003691)	4.00929160
17	Focal seizures (HP:0007359)	3.94488389
18	Difficulty walking (HP:0002355)	3.88833942
19	Erythroderma (HP:0001019)	3.84192752
20	Pancreatic cysts (HP:0001737)	3.53438844
21	Poikilocytosis (HP:0004447)	3.47256505
22	Ulnar bowing (HP:0003031)	3.46490650
23	Conjunctival telangiectasia (HP:0000524)	3.43600684
24	Esophageal varix (HP:0002040)	3.43434477
25	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.35694985
26	Facial shape deformation (HP:0011334)	3.33645824
27	Potter facies (HP:0002009)	3.33645824
28	Overlapping toe (HP:0001845)	3.33281540
29	Ulnar claw (HP:0001178)	3.25816573
30	Bilateral sensorineural hearing impairment (HP:0008619)	3.24721720
31	Radial bowing (HP:0002986)	3.10904045
32	Broad ribs (HP:0000885)	3.05457626
33	Enlarged kidneys (HP:0000105)	2.93112239
34	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.77703062
35	IgM deficiency (HP:0002850)	2.77589944
36	Petechiae (HP:0000967)	2.74315603
37	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.72581365
38	Pendular nystagmus (HP:0012043)	2.68605930
39	Synostosis of carpal bones (HP:0005048)	2.67142831
40	Abnormality of the vocal cords (HP:0008777)	2.64462813
41	Abnormality of the renal cortex (HP:0011035)	2.62434234
42	Hypoplastic iliac wings (HP:0002866)	2.52299411
43	Gangrene (HP:0100758)	2.51346590
44	Portal hypertension (HP:0001409)	2.50670344
45	Autoimmune hemolytic anemia (HP:0001890)	2.41929523
46	Abnormality of the shoulder girdle musculature (HP:0001435)	2.38418075
47	Progressive inability to walk (HP:0002505)	2.37861018
48	Peripheral hypomyelination (HP:0007182)	2.34730565
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.31611762
50	Abnormality of the hepatic vasculature (HP:0006707)	2.28067149
51	Lack of skin elasticity (HP:0100679)	2.27488347
52	Severe visual impairment (HP:0001141)	2.26926744
53	Tarsal synostosis (HP:0008368)	2.26668287
54	Hypokalemia (HP:0002900)	2.25459303
55	Decreased circulating renin level (HP:0003351)	2.20933987
56	Chronic diarrhea (HP:0002028)	2.19698720
57	Thickened calvaria (HP:0002684)	2.19644809
58	Abnormality of the renal medulla (HP:0100957)	2.17879418
59	Albinism (HP:0001022)	2.16954969
60	Dehydration (HP:0001944)	2.15909756
61	Cerebellar dysplasia (HP:0007033)	2.14468995
62	Abnormality of macular pigmentation (HP:0008002)	2.09295586
63	Type I transferrin isoform profile (HP:0003642)	2.09196230
64	Tubulointerstitial fibrosis (HP:0005576)	2.08977289
65	Visceral angiomatosis (HP:0100761)	2.07201605
66	Colitis (HP:0002583)	2.07025439
67	Synostosis involving bones of the feet (HP:0009140)	2.05610815
68	Synostosis involving bones of the lower limbs (HP:0009138)	2.05610815
69	Recurrent sinusitis (HP:0011108)	2.02989404
70	Abnormality of potassium homeostasis (HP:0011042)	2.01795702
71	Hemangiomatosis (HP:0007461)	2.01007313
72	Amelogenesis imperfecta (HP:0000705)	10.3751435
73	Opisthotonus (HP:0002179)	1.99825294
74	Gastrointestinal stroma tumor (HP:0100723)	1.98550133
75	Hypoalbuminemia (HP:0003073)	1.98238256
76	Abnormal albumin level (HP:0012116)	1.98238256
77	Bowing of the arm (HP:0006488)	1.96312858
78	Bowed forearm bones (HP:0003956)	1.96312858
79	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.92179850
80	Chromsome breakage (HP:0040012)	1.92146314
81	Neoplasm of the small intestine (HP:0100833)	1.90996248
82	Purpura (HP:0000979)	1.90606837
83	Right ventricular cardiomyopathy (HP:0011663)	1.85621519
84	Tubular atrophy (HP:0000092)	1.85098296
85	Palmoplantar keratoderma (HP:0000982)	1.84074453
86	Aortic valve stenosis (HP:0001650)	1.81138689
87	Carpal bone hypoplasia (HP:0001498)	1.80641147
88	Cystic liver disease (HP:0006706)	1.79130317
89	Retinitis pigmentosa (HP:0000510)	1.75442344
90	Neoplasm of the colon (HP:0100273)	1.73195867
91	IgA deficiency (HP:0002720)	1.72869996
92	Stomach cancer (HP:0012126)	1.72596889
93	Carpal synostosis (HP:0009702)	1.71485208
94	Pancytopenia (HP:0001876)	1.70837142
95	Nephronophthisis (HP:0000090)	1.70831919
96	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.69997842
97	Abnormality of the wing of the ilium (HP:0011867)	1.67002290
98	Inability to walk (HP:0002540)	1.66392106
99	Ulnar deviation of finger (HP:0009465)	1.64435124
100	Asymmetric septal hypertrophy (HP:0001670)	1.63127479

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.41218730
2	LATS2	6.91609159
3	PRKD3	3.04353293
4	STK38	2.81010461
5	ZAK	2.70922380
6	ACVR1B	2.56256178
7	NLK	2.46250818
8	MAP2K2	2.16284478
9	STK3	2.15287504
10	FRK	2.13151358
11	LATS1	10.9956920
12	MELK	1.97808499
13	BMPR1B	1.58651155
14	MAP3K2	1.25341990
15	KSR2	1.11059182
16	NEK2	1.09030933
17	TAF1	1.06687540
18	PIK3CG	1.03535375
19	IRAK3	1.02447078
20	PDPK1	1.00370102
21	PRKAA2	0.97229150
22	GRK7	0.89145092
23	EIF2AK3	0.82732465
24	TGFBR1	0.78511799
25	CSNK1A1L	0.73776114
26	PINK1	0.72880176
27	TGFBR2	0.69876991
28	ADRBK2	0.66179193
29	PRKD1	0.61078233
30	MOS	0.61054740
31	NEK9	0.58280680
32	ADRBK1	0.50775035
33	DAPK2	0.50047326
34	TTK	0.49377073
35	GRK5	0.44323061
36	NME1	0.42759466
37	MAP2K1	0.37774139
38	STK10	0.34147588
39	TNK2	0.32614618
40	STK11	0.32600009
41	PIM1	0.31691004
42	TAOK3	0.22811422
43	PLK1	0.18874292
44	WNK4	0.17782317
45	PRKCI	0.16559919
46	CSNK1D	0.16184942
47	CHEK2	0.15587346
48	MAPK3	0.10710949
49	CDK3	0.10089724
50	AKT2	0.09599044
51	MAP3K1	0.09338735
52	ABL1	0.09183767
53	TXK	0.08105474
54	OXSR1	0.07819275
55	EIF2AK2	0.07384919
56	FER	0.06404046
57	JAK2	0.05966293
58	ITK	0.05923071
59	TEC	0.04405479
60	RET	0.04202076
61	MAP3K7	0.04059917
62	MAPK1	0.03398388
63	MAP3K8	0.02978523
64	NEK1	0.02066744
65	PRKACA	0.01586912
66	CAMK2B	0.01476283
67	WNK3	0.00944264
68	IRAK4	0.00886805
69	PRKCE	0.00674925
70	STK39	0.00065555
71	CDK2	-0.1141055
72	PRKCZ	-0.1134082
73	CDK19	-0.1109957
74	BTK	-0.1014111
75	ATM	-0.1003294
76	PRKCB	-0.0937154
77	DAPK1	-0.0819154
78	GRK1	-0.0817473
79	PAK1	-0.0813421
80	CDK4	-0.0796880
81	PRKCG	-0.0777137
82	GSK3B	-0.0723861
83	PDGFRA	-0.0721161
84	AKT1	-0.0645587
85	PLK2	-0.0599920
86	NTRK3	-0.0564064
87	PRKCH	-0.0532881
88	PRKG2	-0.0526017
89	ATR	-0.0520901
90	CSNK1A1	-0.0504123
91	CDK5	-0.0459048
92	MAPK7	-0.0365574
93	PLK3	-0.0323705
94	PDK1	-0.0281851
95	MAPK8	-0.0251792
96	PRKACB	-0.0210488
97	NEK6	-0.0205839
98	STK24	-0.0182768
99	PTK2B	-0.0072296
100	CAMK2A	-0.0027020

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	9.17294245
2	Phototransduction_Homo sapiens_hsa04744	4.45887861
3	Sphingolipid metabolism_Homo sapiens_hsa00600	4.02394568
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.89470155
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.26529037
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.88938071
7	Nicotine addiction_Homo sapiens_hsa05033	2.79367495
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.24277341
9	Taste transduction_Homo sapiens_hsa04742	2.12063793
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.10430489
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.96856189
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.91970035
13	Morphine addiction_Homo sapiens_hsa05032	1.74166388
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73128356
15	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.56003544
16	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.45884031
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.43743962
18	Histidine metabolism_Homo sapiens_hsa00340	1.31827053
19	GABAergic synapse_Homo sapiens_hsa04727	1.29956734
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.14927863
21	Viral myocarditis_Homo sapiens_hsa05416	1.12975248
22	One carbon pool by folate_Homo sapiens_hsa00670	1.11719515
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.08874660
24	Calcium signaling pathway_Homo sapiens_hsa04020	1.08578951
25	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.07075627
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06517486
27	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.02182139
28	VEGF signaling pathway_Homo sapiens_hsa04370	1.00771513
29	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.99331976
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95883925
31	Tyrosine metabolism_Homo sapiens_hsa00350	0.95041860
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95002209
33	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.86208339
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84014003
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75109671
36	ABC transporters_Homo sapiens_hsa02010	0.74453421
37	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.72643184
38	Adherens junction_Homo sapiens_hsa04520	0.70598303
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.68906723
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.68043055
41	Bile secretion_Homo sapiens_hsa04976	0.67555570
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67122198
43	Serotonergic synapse_Homo sapiens_hsa04726	0.66246364
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63947816
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63806080
46	Colorectal cancer_Homo sapiens_hsa05210	0.61307022
47	ECM-receptor interaction_Homo sapiens_hsa04512	0.61287361
48	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.60732370
49	Thyroid cancer_Homo sapiens_hsa05216	0.60246424
50	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59378659
51	Basal transcription factors_Homo sapiens_hsa03022	0.58780775
52	Butanoate metabolism_Homo sapiens_hsa00650	0.55981296
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54045484
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52998921
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.52243520
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.50938930
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49710990
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48660239
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.45874505
60	Fatty acid degradation_Homo sapiens_hsa00071	0.45271117
61	Lysine degradation_Homo sapiens_hsa00310	0.44437556
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40647376
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39200274
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38863687
65	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38192447
66	Tuberculosis_Homo sapiens_hsa05152	0.36499422
67	Pancreatic cancer_Homo sapiens_hsa05212	0.36366937
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.35687841
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30541931
70	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.29412166
71	Olfactory transduction_Homo sapiens_hsa04740	0.29312137
72	Homologous recombination_Homo sapiens_hsa03440	0.28138177
73	Salivary secretion_Homo sapiens_hsa04970	0.26244107
74	Cell cycle_Homo sapiens_hsa04110	0.25446555
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.24492112
76	African trypanosomiasis_Homo sapiens_hsa05143	0.23574139
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.23015449
78	Folate biosynthesis_Homo sapiens_hsa00790	0.22059146
79	Oocyte meiosis_Homo sapiens_hsa04114	0.20767540
80	Melanogenesis_Homo sapiens_hsa04916	0.18953852
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.18818009
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.18788420
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.17886135
84	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.16977655
85	Estrogen signaling pathway_Homo sapiens_hsa04915	0.16767599
86	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.16036106
87	Retinol metabolism_Homo sapiens_hsa00830	0.15815363
88	Circadian entrainment_Homo sapiens_hsa04713	0.13461016
89	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.13429155
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.13301267
91	Gap junction_Homo sapiens_hsa04540	0.12833947
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.12782039
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.11440624
94	Metabolic pathways_Homo sapiens_hsa01100	0.11365342
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.10974154
96	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.10721106
97	Gastric acid secretion_Homo sapiens_hsa04971	0.09642476
98	Cholinergic synapse_Homo sapiens_hsa04725	0.07307641
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.06989000
100	Asthma_Homo sapiens_hsa05310	0.06960862

GCNT6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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